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Conserved domains on  [gi|1622911737|ref|XP_014982290|]
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cadherin-15 isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-256 2.44e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 2.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 157 FTGHVLEGAAPGTYVTRAEATDADDPEtdNAALRFSILQQGGPELFSIDELTGEIRTVQvGLDREVVAVYNLTLQVADMS 236
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1622911737 237 GDGLTATASAIITLDDINDN 256
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 379-479 2.54e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 2.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 379 PLRTSLAEGAPPGTLVAIFSAWDPDTEQLQRLSYS-KDYDPEDWLQVDAATGRIQTQRVLSpaspFLKGGWYRAIVLAQD 457
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLD----REEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 1622911737 458 DAPQPRTATGTLSIEILEVNDH 479
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 52-148 1.98e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  52 ISVSENHKrLPYPLVQIK---SDKQQLGSVIYSIqgpgVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLG 128
Cdd:cd11304     4 VSVPENAP-PGTVVLTVSatdPDSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1622911737 129 GSTLEDPTDLEIVVVDQNDN 148
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-371 2.20e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 2.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 278 VGRLEVEDRDLPgsPNWVARFTILEGDPDGQFTIrtDPKTneGVLSIVKALDYESCEHYELKVLVQNEAPLQAaapraeR 357
Cdd:cd11304    16 VLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATDGGGPPL------S 83

                          90
                  ....*....|....
gi 1622911737 358 SQAKVRVHVQDTNE 371
Cdd:cd11304    84 STATVTITVLDVND 97
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 487-580 8.86e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 487 PPGSLC-SEPHQGPGLLLGATDEDLPPHGAPFHFQLSPrlpELGGNWSLSQVNvshARLRPRNQV---PEGLHRLSLLLR 562
Cdd:pfam00028   1 YSASVPeNAPVGTEVLTVTATDPDLGPNGRIFYSILGG---GPGGNFRIDPDT---GDISTTKPLdreSIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 1622911737 563 DSGQPPQQREQPLNVTVC 580
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-256 2.44e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 2.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 157 FTGHVLEGAAPGTYVTRAEATDADDPEtdNAALRFSILQQGGPELFSIDELTGEIRTVQvGLDREVVAVYNLTLQVADMS 236
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1622911737 237 GDGLTATASAIITLDDINDN 256
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 176-258 5.62e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 5.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  176 ATDADDPEtdNAALRFSILQQGGPELFSIDELTGEIRTVQVgLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDIND 255
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 1622911737  256 NAP 258
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
157-250 2.02e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 2.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 157 FTGHVLEGAAPGTYVTRAEATDADDPetDNAALRFSILQQGGPELFSIDELTGEIRTVQVgLDREVVAVYNLTLQVADMS 236
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 1622911737 237 GDGLTATASAIITL 250
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 379-479 2.54e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 2.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 379 PLRTSLAEGAPPGTLVAIFSAWDPDTEQLQRLSYS-KDYDPEDWLQVDAATGRIQTQRVLSpaspFLKGGWYRAIVLAQD 457
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLD----REEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 1622911737 458 DAPQPRTATGTLSIEILEVNDH 479
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 52-148 1.98e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  52 ISVSENHKrLPYPLVQIK---SDKQQLGSVIYSIqgpgVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLG 128
Cdd:cd11304     4 VSVPENAP-PGTVVLTVSatdPDSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1622911737 129 GSTLEDPTDLEIVVVDQNDN 148
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 70-150 4.70e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 4.70e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737   70 SDKQQLGSVIYSIqgpgVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNR 149
Cdd:smart00112   5 ADSGENGKVTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1622911737  150 P 150
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
383-474 4.24e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 4.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 383 SLAEGAPPGTLVAIFSAWDPDTEQLQRLSYSKDYD-PEDWLQVDAATGRIQTQRVLSPASPflkgGWYRAIVLAQDDAPQ 461
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 1622911737 462 PRTATGTLSIEIL 474
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-371 2.20e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 2.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 278 VGRLEVEDRDLPgsPNWVARFTILEGDPDGQFTIrtDPKTneGVLSIVKALDYESCEHYELKVLVQNEAPLQAaapraeR 357
Cdd:cd11304    16 VLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATDGGGPPL------S 83

                          90
                  ....*....|....
gi 1622911737 358 SQAKVRVHVQDTNE 371
Cdd:cd11304    84 STATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
278-367 7.25e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 7.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 278 VGRLEVEDRDLPgsPNWVARFTILEGDPDGQFTIrtDPKTneGVLSIVKALDYESCEHYELKVLVQNEaplqaaAPRAER 357
Cdd:pfam00028  15 VLTVTATDPDLG--PNGRIFYSILGGGPGGNFRI--DPDT--GDISTTKPLDRESIGEYELTVEATDS------GGPPLS 82

                          90
                  ....*....|
gi 1622911737 358 SQAKVRVHVQ 367
Cdd:pfam00028  83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 398-481 1.39e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  398 SAWDPDTEQLQRLSYSKDYDPED-WLQVDAATGRIQTQRVLSpaspFLKGGWYRAIVLAQDDAPQPRTATGTLSIEILEV 476
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDgLFSIDPETGEITTTKPLD----REEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 1622911737  477 NDHAP 481
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-373 2.51e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 2.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  283 VEDRDLPgsPNWVARFTILEGDPDGQFTIrtDPKTneGVLSIVKALDYESCEHYELKVLVQNEAPLQAaapraeRSQAKV 362
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPL------SSTATV 69

                           90
                   ....*....|.
gi 1622911737  363 RVHVQDTNEPP 373
Cdd:smart00112  70 TITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
50-142 6.89e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 6.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  50 PPISVSENHKR--LPYPLVQIKSDKQQLGSVIYSIQGPGVDeeprGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDL 127
Cdd:pfam00028   1 YSASVPENAPVgtEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 1622911737 128 GGSTLEDPTDLEIVV 142
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
487-580 8.86e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 487 PPGSLC-SEPHQGPGLLLGATDEDLPPHGAPFHFQLSPrlpELGGNWSLSQVNvshARLRPRNQV---PEGLHRLSLLLR 562
Cdd:pfam00028   1 YSASVPeNAPVGTEVLTVTATDPDLGPNGRIFYSILGG---GPGGNFRIDPDT---GDISTTKPLdreSIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 1622911737 563 DSGQPPQQREQPLNVTVC 580
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-256 2.44e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 2.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 157 FTGHVLEGAAPGTYVTRAEATDADDPEtdNAALRFSILQQGGPELFSIDELTGEIRTVQvGLDREVVAVYNLTLQVADMS 236
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1622911737 237 GDGLTATASAIITLDDINDN 256
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 176-258 5.62e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 5.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  176 ATDADDPEtdNAALRFSILQQGGPELFSIDELTGEIRTVQVgLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDIND 255
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 1622911737  256 NAP 258
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
157-250 2.02e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 2.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 157 FTGHVLEGAAPGTYVTRAEATDADDPetDNAALRFSILQQGGPELFSIDELTGEIRTVQVgLDREVVAVYNLTLQVADMS 236
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 1622911737 237 GDGLTATASAIITL 250
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 379-479 2.54e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 2.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 379 PLRTSLAEGAPPGTLVAIFSAWDPDTEQLQRLSYS-KDYDPEDWLQVDAATGRIQTQRVLSpaspFLKGGWYRAIVLAQD 457
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLD----REEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 1622911737 458 DAPQPRTATGTLSIEILEVNDH 479
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 52-148 1.98e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  52 ISVSENHKrLPYPLVQIK---SDKQQLGSVIYSIqgpgVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLG 128
Cdd:cd11304     4 VSVPENAP-PGTVVLTVSatdPDSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1622911737 129 GSTLEDPTDLEIVVVDQNDN 148
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 70-150 4.70e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 4.70e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737   70 SDKQQLGSVIYSIqgpgVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNR 149
Cdd:smart00112   5 ADSGENGKVTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1622911737  150 P 150
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
383-474 4.24e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 4.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 383 SLAEGAPPGTLVAIFSAWDPDTEQLQRLSYSKDYD-PEDWLQVDAATGRIQTQRVLSPASPflkgGWYRAIVLAQDDAPQ 461
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 1622911737 462 PRTATGTLSIEIL 474
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-371 2.20e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 2.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 278 VGRLEVEDRDLPgsPNWVARFTILEGDPDGQFTIrtDPKTneGVLSIVKALDYESCEHYELKVLVQNEAPLQAaapraeR 357
Cdd:cd11304    16 VLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATDGGGPPL------S 83

                          90
                  ....*....|....
gi 1622911737 358 SQAKVRVHVQDTNE 371
Cdd:cd11304    84 STATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
278-367 7.25e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 7.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 278 VGRLEVEDRDLPgsPNWVARFTILEGDPDGQFTIrtDPKTneGVLSIVKALDYESCEHYELKVLVQNEaplqaaAPRAER 357
Cdd:pfam00028  15 VLTVTATDPDLG--PNGRIFYSILGGGPGGNFRI--DPDT--GDISTTKPLDRESIGEYELTVEATDS------GGPPLS 82

                          90
                  ....*....|
gi 1622911737 358 SQAKVRVHVQ 367
Cdd:pfam00028  83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 398-481 1.39e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  398 SAWDPDTEQLQRLSYSKDYDPED-WLQVDAATGRIQTQRVLSpaspFLKGGWYRAIVLAQDDAPQPRTATGTLSIEILEV 476
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDgLFSIDPETGEITTTKPLD----REEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 1622911737  477 NDHAP 481
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-373 2.51e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 2.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  283 VEDRDLPgsPNWVARFTILEGDPDGQFTIrtDPKTneGVLSIVKALDYESCEHYELKVLVQNEAPLQAaapraeRSQAKV 362
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPL------SSTATV 69

                           90
                   ....*....|.
gi 1622911737  363 RVHVQDTNEPP 373
Cdd:smart00112  70 TITVLDVNDNA 80
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-148 4.26e-13

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 65.44  E-value: 4.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  49 IPPISVSENHKRlPYPLVQIKSDKQQLGSVIYSIQGPGvDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLG 128
Cdd:cd00031     1 IPDGSAVEGRSR-GSFRVSIPTDLIASSGEIIKISAAG-KEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                          90       100
                  ....*....|....*....|
gi 1622911737 129 GSTLEDPTDLEIVVVDQNDN 148
Cdd:cd00031    79 ANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
50-142 6.89e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 6.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737  50 PPISVSENHKR--LPYPLVQIKSDKQQLGSVIYSIQGPGVDeeprGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDL 127
Cdd:pfam00028   1 YSASVPENAPVgtEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 1622911737 128 GGSTLEDPTDLEIVV 142
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
487-580 8.86e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911737 487 PPGSLC-SEPHQGPGLLLGATDEDLPPHGAPFHFQLSPrlpELGGNWSLSQVNvshARLRPRNQV---PEGLHRLSLLLR 562
Cdd:pfam00028   1 YSASVPeNAPVGTEVLTVTATDPDLGPNGRIFYSILGG---GPGGNFRIDPDT---GDISTTKPLdreSIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 1622911737 563 DSGQPPQQREQPLNVTVC 580
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
GH32_Inu-like cd18622
glycoside hydrolase family 32 protein such as Aspergillus ficuum endo-inulinase (Inu2); This ...
 382-415 9.58e-03

glycoside hydrolase family 32 protein such as Aspergillus ficuum endo-inulinase (Inu2); This subfamily of glycosyl hydrolase family GH32 includes endo-inulinase (inu2, EC 3.2.1.7), exo-inulinase (Inu1, EC 3.2.1.80), invertase (EC 3.2.1.26), and levan fructotransferase (LftA, EC 4.2.2.16), among others. These enzymes cleave sucrose into fructose and glucose via beta-fructofuranosidase activity, producing invert sugar that is a mixture of dextrorotatory D-glucose and levorotatory D-fructose, thus named invertase (EC 3.2.1.26). These retaining enzymes (i.e. they retain the configuration at anomeric carbon atom of the substrate) catalyze hydrolysis in two steps involving a covalent glycosyl enzyme intermediate: an aspartate located close to the N-terminus acts as the catalytic nucleophile and a glutamate acts as the general acid/base; a conserved aspartate residue in the Arg-Asp-Pro (RDP) motif stabilizes the transition state. These enzymes are predicted to display a 5-fold beta-propeller fold as found for GH43 and CH68. The breakdown of sucrose is widely used as a carbon or energy source by bacteria, fungi, and plants. Invertase is used commercially in the confectionery industry, since fructose has a sweeter taste than sucrose and a lower tendency to crystallize. A common structural feature of all these enzymes is a 5-bladed beta-propeller domain, similar to GH43, that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.


Pssm-ID: 350134  Cd Length: 289  Bit Score: 38.36  E-value: 9.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622911737 382 TSLAEGAPPGTLVAIFSAWDPDTEQLQRLSYSKD 415
Cdd:cd18622    74 TSGLGGFGKGALVAIYTSAGPDGGQTQSLAYSTD 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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