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Conserved domains on  [gi|967489481|ref|XP_014977492|]
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lung adenoma susceptibility protein 2 isoform X1 [Macaca mulatta]

Protein Classification

LAS2 domain-containing protein( domain architecture ID 11239280)

LAS2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 161-235 7.96e-35

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


:

Pssm-ID: 464872  Cd Length: 75  Bit Score: 125.28  E-value: 7.96e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967489481  161 SSDVEKNPNFQGPSTPVGKDNFVTPVVCTNINGKQCGRLKNPKLMNRTNNCISESSLSFPKKSSFKDSSEHSLEK 235
Cdd:pfam15792   1 SLDIEKNPNFQEPSTPMGKDNLVTPVVYTNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSFKDSSPCSLEK 75
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 327-394 3.27e-15

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


:

Pssm-ID: 464872  Cd Length: 75  Bit Score: 70.58  E-value: 3.27e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967489481  327 ELVNEYKCDFEH-SQCECENPLLP-----GQSTKPFSGDKIELLILKAKRNLEQCTEELPKSMK-KDDSPCSLDK 394
Cdd:pfam15792   1 SLDIEKNPNFQEpSTPMGKDNLVTpvvytNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSfKDSSPCSLEK 75
 
Name Accession Description Interval E-value
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 161-235 7.96e-35

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


Pssm-ID: 464872  Cd Length: 75  Bit Score: 125.28  E-value: 7.96e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967489481  161 SSDVEKNPNFQGPSTPVGKDNFVTPVVCTNINGKQCGRLKNPKLMNRTNNCISESSLSFPKKSSFKDSSEHSLEK 235
Cdd:pfam15792   1 SLDIEKNPNFQEPSTPMGKDNLVTPVVYTNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSFKDSSPCSLEK 75
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 327-394 3.27e-15

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


Pssm-ID: 464872  Cd Length: 75  Bit Score: 70.58  E-value: 3.27e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967489481  327 ELVNEYKCDFEH-SQCECENPLLP-----GQSTKPFSGDKIELLILKAKRNLEQCTEELPKSMK-KDDSPCSLDK 394
Cdd:pfam15792   1 SLDIEKNPNFQEpSTPMGKDNLVTpvvytNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSfKDSSPCSLEK 75
 
Name Accession Description Interval E-value
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 161-235 7.96e-35

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


Pssm-ID: 464872  Cd Length: 75  Bit Score: 125.28  E-value: 7.96e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967489481  161 SSDVEKNPNFQGPSTPVGKDNFVTPVVCTNINGKQCGRLKNPKLMNRTNNCISESSLSFPKKSSFKDSSEHSLEK 235
Cdd:pfam15792   1 SLDIEKNPNFQEPSTPMGKDNLVTPVVYTNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSFKDSSPCSLEK 75
LAS2 pfam15792
Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of ...
 327-394 3.27e-15

Lung adenoma susceptibility protein 2; LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis.


Pssm-ID: 464872  Cd Length: 75  Bit Score: 70.58  E-value: 3.27e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967489481  327 ELVNEYKCDFEH-SQCECENPLLP-----GQSTKPFSGDKIELLILKAKRNLEQCTEELPKSMK-KDDSPCSLDK 394
Cdd:pfam15792   1 SLDIEKNPNFQEpSTPMGKDNLVTpvvytNINGKQCGRLKNPKLINKANKCLSESSLSFPKKSSfKDSSPCSLEK 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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