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Conserved domains on  [gi|967325074|ref|XP_014976591|]
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integrator complex subunit 6 isoform X1 [Macaca mulatta]

Protein Classification

integrator subunit 6 family protein( domain architecture ID 11219369)

integrator subunit 6 family protein similar to integrator complex subunit 6 (INTS6) is a component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing

CATH:  3.40.50.410
Gene Ontology:  GO:0034472|GO:0032039
PubMed:  12579041|10830113|12388743
SCOP:  3000832

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
INT_SG_DDX_CT_C pfam15300
INTS6/SAGE1/DDX26B/CT45 C-terminus; This domain is found at the C-terminus of integrator ...
 807-868 6.16e-29

INTS6/SAGE1/DDX26B/CT45 C-terminus; This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.


:

Pssm-ID: 464626  Cd Length: 62  Bit Score: 109.89  E-value: 6.16e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 967325074  807 EVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLE 868
Cdd:pfam15300   1 EHNAELKKQVFKEIRRPGRNYEKIFKLLEQVQGPLEIRKKFVEDVIKEAARFKRRVLIQQLE 62
VWA_2 pfam13519
von Willebrand factor type A domain;
4-103 1.10e-16

von Willebrand factor type A domain;


:

Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 76.18  E-value: 1.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074    4 LLFLIDTSASMNQRShLGTTYLDTAKGAVETFMKLRardpasRGDRYMLVTFEEPPYaIKAGWKENHATFMNELKNLQAE 83
Cdd:pfam13519   1 LVFVLDTSGSMRNGD-YGPTRLEAAKDAVLALLKSL------PGDRVGLVTFGDGPE-VLIPLTKDRAKILRALRRLEPK 72

                          90       100
                  ....*....|....*....|.
gi 967325074   84 -GLTTLGQSLRTAFDLLNLNR 103
Cdd:pfam13519  73 gGGTNLAAALQLARAALKHRR 93
 
Name Accession Description Interval E-value
INT_SG_DDX_CT_C pfam15300
INTS6/SAGE1/DDX26B/CT45 C-terminus; This domain is found at the C-terminus of integrator ...
 807-868 6.16e-29

INTS6/SAGE1/DDX26B/CT45 C-terminus; This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.


Pssm-ID: 464626  Cd Length: 62  Bit Score: 109.89  E-value: 6.16e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 967325074  807 EVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLE 868
Cdd:pfam15300   1 EHNAELKKQVFKEIRRPGRNYEKIFKLLEQVQGPLEIRKKFVEDVIKEAARFKRRVLIQQLE 62
VWA_2 pfam13519
von Willebrand factor type A domain;
4-103 1.10e-16

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 76.18  E-value: 1.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074    4 LLFLIDTSASMNQRShLGTTYLDTAKGAVETFMKLRardpasRGDRYMLVTFEEPPYaIKAGWKENHATFMNELKNLQAE 83
Cdd:pfam13519   1 LVFVLDTSGSMRNGD-YGPTRLEAAKDAVLALLKSL------PGDRVGLVTFGDGPE-VLIPLTKDRAKILRALRRLEPK 72

                          90       100
                  ....*....|....*....|.
gi 967325074   84 -GLTTLGQSLRTAFDLLNLNR 103
Cdd:pfam13519  73 gGGTNLAAALQLARAALKHRR 93
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 4-131 9.45e-12

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 64.12  E-value: 9.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074   4 LLFLIDTSASMnqrshlGTTYLDTAKGAVETFmkLRARDPASRGDRYMLVTFEEPPY----AIKAGWKENHATFMNELKN 79
Cdd:cd00198    3 IVFLLDVSGSM------GGEKLDKAKEALKAL--VSSLSASPPGDRVGLVTFGSNARvvlpLTTDTDKADLLEAIDALKK 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 967325074  80 lQAEGLTTLGQSLRTAFDLLNLNRLVTGidnygqgrnpfflePAIIITITDG 131
Cdd:cd00198   75 -GLGGGTNIGAALRLALELLKSAKRPNA--------------RRVIILLTDG 111
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 4-131 7.37e-10

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 60.72  E-value: 7.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074   4 LLFLIDTSASMNQRSHlgttyLDTAKGAVETFMKLrardpASRGDRYMLVTFEEPPYaIKAGWKENHATFMNELKNLQAE 83
Cdd:COG1240   95 VVLVVDASGSMAAENR-----LEAAKGALLDFLDD-----YRPRDRVGLVAFGGEAE-VLLPLTRDREALKRALDELPPG 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 967325074  84 GLTTLGQSLRTAFDLLnlnrlvtgiDNYGQGRNPfflepaIIITITDG 131
Cdd:COG1240  164 GGTPLGDALALALELL---------KRADPARRK------VIVLLTDG 196
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 4-131 4.58e-08

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 53.61  E-value: 4.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074     4 LLFLIDTSASMNQRshlgttYLDTAKGAVETFMKLRARDPasRGDRYMLVTF-EEPPYAIKAGWKENHATFMNELKNLQ- 81
Cdd:smart00327   2 VVFLLDGSGSMGGN------RFELAKEFVLKLVEQLDIGP--DGDRVGLVTFsDDARVLFPLNDSRSKDALLEALASLSy 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 967325074    82 -AEGLTTLGQSLRTAFDLLNLNRlvtgidnygQGRNPFFlePAIIITITDG 131
Cdd:smart00327  74 kLGGGTNLGAALQYALENLFSKS---------AGSRRGA--PKVVILITDG 113
 
Name Accession Description Interval E-value
INT_SG_DDX_CT_C pfam15300
INTS6/SAGE1/DDX26B/CT45 C-terminus; This domain is found at the C-terminus of integrator ...
 807-868 6.16e-29

INTS6/SAGE1/DDX26B/CT45 C-terminus; This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.


Pssm-ID: 464626  Cd Length: 62  Bit Score: 109.89  E-value: 6.16e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 967325074  807 EVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLE 868
Cdd:pfam15300   1 EHNAELKKQVFKEIRRPGRNYEKIFKLLEQVQGPLEIRKKFVEDVIKEAARFKRRVLIQQLE 62
VWA_2 pfam13519
von Willebrand factor type A domain;
4-103 1.10e-16

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 76.18  E-value: 1.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074    4 LLFLIDTSASMNQRShLGTTYLDTAKGAVETFMKLRardpasRGDRYMLVTFEEPPYaIKAGWKENHATFMNELKNLQAE 83
Cdd:pfam13519   1 LVFVLDTSGSMRNGD-YGPTRLEAAKDAVLALLKSL------PGDRVGLVTFGDGPE-VLIPLTKDRAKILRALRRLEPK 72

                          90       100
                  ....*....|....*....|.
gi 967325074   84 -GLTTLGQSLRTAFDLLNLNR 103
Cdd:pfam13519  73 gGGTNLAAALQLARAALKHRR 93
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 4-131 9.45e-12

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 64.12  E-value: 9.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074   4 LLFLIDTSASMnqrshlGTTYLDTAKGAVETFmkLRARDPASRGDRYMLVTFEEPPY----AIKAGWKENHATFMNELKN 79
Cdd:cd00198    3 IVFLLDVSGSM------GGEKLDKAKEALKAL--VSSLSASPPGDRVGLVTFGSNARvvlpLTTDTDKADLLEAIDALKK 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 967325074  80 lQAEGLTTLGQSLRTAFDLLNLNRLVTGidnygqgrnpfflePAIIITITDG 131
Cdd:cd00198   75 -GLGGGTNIGAALRLALELLKSAKRPNA--------------RRVIILLTDG 111
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 4-131 7.37e-10

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 60.72  E-value: 7.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074   4 LLFLIDTSASMNQRSHlgttyLDTAKGAVETFMKLrardpASRGDRYMLVTFEEPPYaIKAGWKENHATFMNELKNLQAE 83
Cdd:COG1240   95 VVLVVDASGSMAAENR-----LEAAKGALLDFLDD-----YRPRDRVGLVAFGGEAE-VLLPLTRDREALKRALDELPPG 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 967325074  84 GLTTLGQSLRTAFDLLnlnrlvtgiDNYGQGRNPfflepaIIITITDG 131
Cdd:COG1240  164 GGTPLGDALALALELL---------KRADPARRK------VIVLLTDG 196
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 4-131 4.58e-08

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 53.61  E-value: 4.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074     4 LLFLIDTSASMNQRshlgttYLDTAKGAVETFMKLRARDPasRGDRYMLVTF-EEPPYAIKAGWKENHATFMNELKNLQ- 81
Cdd:smart00327   2 VVFLLDGSGSMGGN------RFELAKEFVLKLVEQLDIGP--DGDRVGLVTFsDDARVLFPLNDSRSKDALLEALASLSy 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 967325074    82 -AEGLTTLGQSLRTAFDLLNLNRlvtgidnygQGRNPFFlePAIIITITDG 131
Cdd:smart00327  74 kLGGGTNLGAALQYALENLFSKS---------AGSRRGA--PKVVILITDG 113
YfbK COG2304
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ...
 4-143 1.90e-05

Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only];


Pssm-ID: 441879 [Multi-domain]  Cd Length: 289  Bit Score: 47.40  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074   4 LLFLIDTSASMNQRShlgttyLDTAKGAVETFM-KLRArdpasrGDRYMLVTFEE------PPYAIkagwkENHATFMNE 76
Cdd:COG2304   94 LVFVIDVSGSMSGDK------LELAKEAAKLLVdQLRP------GDRVSIVTFAGdarvllPPTPA-----TDRAKILAA 156

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967325074  77 LKNLQAEGLTTLGQSLRTAFDLLNlnrlvtgiDNYGQGRnpfflePAIIITITDGSkltTTSGVQDE 143
Cdd:COG2304  157 IDRLQAGGGTALGAGLELAYELAR--------KHFIPGR------VNRVILLTDGD---ANVGITDP 206
vWA_interalpha_trypsin_inhibitor cd01461
vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- ...
 4-150 2.09e-03

vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to the extracellular matrix by binding to hyaluronic acid. The heavy chains carry the VWA domain with a conserved MIDAS motif. Although the exact role of the VWA domains remains unknown, it has been speculated to be involved in mediating protein-protein interactions with the components of the extracellular matrix.


Pssm-ID: 238738 [Multi-domain]  Cd Length: 171  Bit Score: 39.89  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074   4 LLFLIDTSASMNQRShlgttyLDTAKGAVETFMK-LRArdpasrGDRYMLVTF-----EEPPYAIKAGwKENHATFMNEL 77
Cdd:cd01461    5 VVFVIDTSGSMSGTK------IEQTKEALLTALKdLPP------GDYFNIIGFsdtveEFSPSSVSAT-AENVAAAIEYV 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967325074  78 KNLQAEGLTTLGQSLRTAFDLLNLNrlvtgidnygQGRnpfflePAIIITITDGSkLTTTSGVQDELHLPLNS 150
Cdd:cd01461   72 NRLQALGGTNMNDALEAALELLNSS----------PGS------VPQIILLTDGE-VTNESQILKNVREALSG 127
ViaA COG2425
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ...
 4-131 3.02e-03

Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown];


Pssm-ID: 441973 [Multi-domain]  Cd Length: 263  Bit Score: 40.43  E-value: 3.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074   4 LLFLIDTSASMnqrshlGTTYLDTAKGAVETFMKLRArdpasRGDRYMLVTFE---EPPYAIKAgwKENHATFMNELKNL 80
Cdd:COG2425  121 VVLCVDTSGSM------AGSKEAAAKAAALALLRALR-----PNRRFGVILFDtevVEDLPLTA--DDGLEDAIEFLSGL 187

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967325074  81 QAEGLTTLGQSLRTAFDLLnlnrlvtgidnygqgRNPFFlEPAIIITITDG 131
Cdd:COG2425  188 FAGGGTDIAPALRAALELL---------------EEPDY-RNADIVLITDG 222
YeaD2 COG1721
Uncharacterized conserved protein, DUF58 family, contains vWF domain [Function unknown];
4-99 5.18e-03

Uncharacterized conserved protein, DUF58 family, contains vWF domain [Function unknown];


Pssm-ID: 441327 [Multi-domain]  Cd Length: 287  Bit Score: 39.81  E-value: 5.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967325074   4 LLFLIDTSASMNQRSHlGTTYLDTAKGAVETFMKLRARdpasRGDRYMLVTF-EEPPYAIKAGWKENHAT-FMNELKNLQ 81
Cdd:COG1721  150 VVLLLDTSASMRFGSG-GPSKLDLAVEAAASLAYLALR----QGDRVGLLTFgDRVRRYLPPRRGRRHLLrLLEALARLE 224

                         90
                 ....*....|....*...
gi 967325074  82 AEGLTTLGQSLRTAFDLL 99
Cdd:COG1721  225 PAGETDLAAALRRLARRL 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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