|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
1-452 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 620.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 1 MPQALER----ADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGR 76
Cdd:TIGR00892 1 MPPALPPegppPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 77 FGCRVTTMLGGVLASLGMVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWP 156
Cdd:TIGR00892 81 FGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 157 LLSRYLLEDLGWRGTFLVFGGVFLHCCICGAIMRPVATS---VAPETKECPPPPPETPALGCVaACGRTIQRHLAFDILR 233
Cdd:TIGR00892 161 PLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSqrvSKSKSKEGLPPDGSTKKLSKK-STAEKINRFLDFSLFT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 234 HnTGYCVYVLGVMWSILGFPLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLAFL 313
Cdd:TIGR00892 240 H-RGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 314 LNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNN 393
Cdd:TIGR00892 319 FNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKN 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 967210437 394 FSYVFFMSSFFLISAALFMGGSFYALQKKEQGKRavvADALEQDIFLEAKDGPGKQRSP 452
Cdd:TIGR00892 399 YKYIFYASGSIVVSAGLFLAIGNYINYRLLAKEQ---KAALEREGARDKKDAEGDSRES 454
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
13-416 |
0e+00 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 584.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 13 AWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASL 92
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 93 GMVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTF 172
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 173 LVFGGVFLHCCICGAIMRPvatsvapetkecpppppetpalgcvaacgrtiqrhlafdiLRHNTGYCVYVLGVMWSILGF 252
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP----------------------------------------FCSNTRYQIYTLGVTWMVLGF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 253 PLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLAFLLNGLTNLVCAASGDFWVLV 332
Cdd:cd17425 201 VLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 333 GYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17425 281 VYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFM 360
|
....
gi 967210437 413 GGSF 416
Cdd:cd17425 361 GLSF 364
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-415 |
1.13e-104 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 315.65 E-value: 1.13e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 13 AWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASL 92
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 93 GMVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTF 172
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 173 LVFGGVFLHCCICGAIMRpvatsvapetkecpppppetpalgcvaacgrtiqrhlafdiLRHNTGYCVYVLGVMWSILGF 252
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-----------------------------------------LLKDPTFVLLALGVSFAMLGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 253 PLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFasHRKYLFSLAFLLNGLTNLVCAASGDFWVLV 332
Cdd:cd17352 200 FVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRI--GRLYLYIFTLLILGLSLLAFPLATTYVGLI 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 333 GYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17352 278 VFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLL 357
|
...
gi 967210437 413 GGS 415
Cdd:cd17352 358 FLL 360
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
13-412 |
1.89e-99 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 302.42 E-value: 1.89e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 13 AWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASL 92
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 93 GMVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTF 172
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 173 LVFGGVFLHCCICGAIMRPvatsvapetkecpppppetpalgcvaacgrtiqrhLAFDILRhNTGYCVYVLGVMWSILGF 252
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP-----------------------------------LDFSVFR-DRGFVIYTIAKFIMVLGL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 253 PLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLAFLLNGLTNLVCAASGDFWVLV 332
Cdd:cd17430 205 FVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGGLV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 333 GYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17430 285 VFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFL 364
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
14-412 |
3.32e-76 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 242.80 E-value: 3.32e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 14 WVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLG 93
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 94 MVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFL 173
Cdd:cd17427 82 MISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 174 VFGGVFLHCCICGAIMRPVATsvapetkecpppppetpalgcvaacgrtiqrhlafdiLRHNTGYCVYVLGVMWSILGFP 253
Cdd:cd17427 162 ILGGLLLNCCVAGSLMRPLGP-------------------------------------LFKHRGFLIYLSGNVIMFLGFF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 254 LPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLAFLLNGLTNLVCAASGDFWVLVG 333
Cdd:cd17427 205 APIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVI 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967210437 334 YCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17427 285 YAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWL 363
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
14-412 |
6.91e-65 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 213.59 E-value: 6.91e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 14 WVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLG 93
Cdd:cd17426 2 WAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 94 MVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFL 173
Cdd:cd17426 82 LIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 174 VFGGVFLHCCICGAIMRPVATsvapetkecpppppetpalgcvaacgrtiQRHLAFDILRHNtGYCVYVLGVMWSILGFP 253
Cdd:cd17426 162 ILGGLLLNCCVAGSLMRPIGP-----------------------------KPFLDLTLFTHR-GFLLYLSGNVIMFFGLF 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 254 LPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLAFLLNGLTNLVCAASGDFWVLVG 333
Cdd:cd17426 212 APLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGFCI 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967210437 334 YCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17426 292 YAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYL 370
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
14-419 |
9.39e-59 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 196.89 E-value: 9.39e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 14 WVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLG 93
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 94 MVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFL 173
Cdd:cd17422 82 MITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 174 VFGGVFLHCCICGAIMRpvatsvapetkecpppppetpalgcvaacgrtiqrhlafdILRhNTGYCVYVLGVMWSILGFP 253
Cdd:cd17422 162 VVGALQLNIVVCGALLR----------------------------------------VLK-EPGFICYALFGLFATLGFF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 254 LPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFashRK-YLFSLAFLLNGLTNLVCAASGDFWVLV 332
Cdd:cd17422 201 APQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPI---RKiYIELICVILLCVVLLLFPFAYGFWSLL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 333 GYCLVYSVSMSGIGALIFQVLM--DIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSyvffmSSFFLISAAL 410
Cdd:cd17422 278 VCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYG-----SAFYSCAAGM 352
|
....*....
gi 967210437 411 FMGGSFYAL 419
Cdd:cd17422 353 ALGAVFLAL 361
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
14-410 |
1.46e-55 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 189.14 E-value: 1.46e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 14 WVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLG 93
Cdd:cd17423 2 WVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 94 MVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFL 173
Cdd:cd17423 82 FLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 174 VFGGVFLHCCICGAIMRPVATSvapetkecpppppetpalGCVAACGRTIQRHLAFDILRHNtGYCVYVLGVMWSILGFP 253
Cdd:cd17423 162 LLSALSLHLVPCGALLRPLALP------------------GDPPAPPRSLSAAFGLSLLTHR-AFLRYALATTLINTGYF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 254 LPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFAShrKYLFSLAFLLNGLTNLVCAASGDFWVLVG 333
Cdd:cd17423 223 IPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTALTGLSLLLLPLAKVYGSLLA 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967210437 334 YCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAAL 410
Cdd:cd17423 301 LAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSL 377
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
14-413 |
6.03e-48 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 168.45 E-value: 6.03e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 14 WVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLG 93
Cdd:cd17424 2 WMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 94 MVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFL 173
Cdd:cd17424 82 LILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 174 VFGGVFLHCCICGAIMRPVATSvapetkecpppppetpalgcvaacgrtiqrhlafdilrhntGYCVYVLGVMWSILGFP 253
Cdd:cd17424 162 ILGGFVLNLCVCGALMRFLLMP-----------------------------------------DFLVLAVSVLFLAYGCS 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 254 LPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLAFLLNGLTNLVCAASGDFWVLVG 333
Cdd:cd17424 201 PPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLLVP 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 334 YCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFMG 413
Cdd:cd17424 281 FSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLG 360
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
13-412 |
8.31e-39 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 144.20 E-value: 8.31e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 13 AWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASL 92
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 93 GMVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPlLSRYLLEDLGWRGTF 172
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFALAP-FTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 173 LVFGGVFLHCCICGAIMRPVATSvapetkecpppppetpalgcvaacgrtiqrhlafdiLRHNTGYCVYVLGVMWSILGF 252
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPIDFS------------------------------------LLKDPFFCIYTWSFVFSQLAY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 253 PLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFashRKYLFSLAFL-LNGLTNLVCAASGDFWVL 331
Cdd:cd17421 204 FIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWI---KKYHYHKAYLiLCGVTNLLAPLATTYPLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 332 VGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSS--FFLISAA 409
Cdd:cd17421 281 MTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGgcYLLSSVS 360
|
...
gi 967210437 410 LFM 412
Cdd:cd17421 361 FFL 363
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
13-401 |
1.91e-36 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 138.43 E-value: 1.91e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 13 AWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASN-----SQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGG 87
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKLGdpeasFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 88 VLASLGMVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLG 167
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 168 WRGTFLVFGGVFLHCCICGAIMRPVATSVAPETKECPPPPPETPALGcvaacgrTIQRHLAFDILRHNTgYCVYVLGVMW 247
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLHSRINL-------FLRKIFNVEIFKRKR-YVIWALGIPL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 248 SILGFPLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfASHRKYLFSLAFLLNGLTNLVCAASGD 327
Cdd:cd17420 233 ALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPP-GVKKMYLQVLSFVSIGLMSMMIPLCNS 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 967210437 328 FWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMS 401
Cdd:cd17420 312 FGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLA 385
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
13-412 |
4.61e-35 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 133.80 E-value: 4.61e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 13 AWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASL 92
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 93 GMVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTF 172
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 173 LVFGGVFLHCCICGAIMRpvatsvapetkecpppppetpalgcvaacgrtiqrhlafdiLRHNTGYCVYVLGVMWSILGF 252
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-----------------------------------------LFTNKVFVAFIFWALFAYCSF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 253 PLPQVFLVPYAMWHRMDEQQAAL-LISIIGFSNIFLRPLAGLMAGRPAFASHRkyLFSLAFLLNGLTNLVCAASGDFWVL 331
Cdd:cd17429 200 VIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCISVWN--VFILANFTLGVCILILPLMHTYTGL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 332 VGYCLVYSVSmSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALF 411
Cdd:cd17429 278 AIVCALIGFS-SGYFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIIC 356
|
.
gi 967210437 412 M 412
Cdd:cd17429 357 L 357
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-412 |
1.37e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 119.22 E-value: 1.37e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 13 AWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASL 92
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 93 GMVASSFSRNLSQLyFTAGFITGLGMCFSFQSSVTVLGFYFVRRRV-LANALASMGVSLGITLWPLLSRYLLEDLGWRGT 171
Cdd:COG2223 83 GLLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRgLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 172 FLVFGGVFLhccICGAIMRPVATSVAPETKEcpppppetpalgcVAACGRTIQRHLAFDilRHNTGYCVYVLGVMWSILG 251
Cdd:COG2223 162 FLILGILLL---VVAVLAWLFLRDPPAGAAA-------------AAKASLRDQLEALRD--PRFWLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 252 FplpQVFLVPYAM-WHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRpaFASHRKYLFSLAFLLNGLTnLVCAASGDFWV 330
Cdd:COG2223 224 F---SSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDR--IGGRRVLLIVFALMALGLL-LLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 331 LVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAAL 410
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
..
gi 967210437 411 FM 412
Cdd:COG2223 378 LT 379
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
14-401 |
2.36e-27 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 112.96 E-value: 2.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 14 WVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNS-----QTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGV 88
Cdd:cd17464 2 WVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDaqmrfKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 89 LASLGMVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGW 168
Cdd:cd17464 82 VGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 169 RGTFLVFGGVFLHCCICGAIMRPVATSVAPETKECPPPPPEtpalgcvaacgrTIQRHLAFDILRhNTGYCVYVLGVMWS 248
Cdd:cd17464 162 FNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKKRKFKCP------------PLKKIFNFNIWK-STGYRIWAFGIPAA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 249 ILGFPLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfASHRKYLFSLAFLLNGLTNLVCAASGDF 328
Cdd:cd17464 229 LFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIP-GVKKVYLQVSSFFFIGLMSMMIPLCHVF 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967210437 329 WVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMS 401
Cdd:cd17464 308 GGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLA 380
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
14-412 |
2.58e-25 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 106.44 E-value: 2.58e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 14 WVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLG 93
Cdd:cd17428 2 WVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 94 MVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFL 173
Cdd:cd17428 82 LMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 174 VFGGVFLHCCICGAIMRPVATSVApetkecpppppetpalgcvaacgrtiqrhlafdilrhnTGYCVYVLgvMWSILGFP 253
Cdd:cd17428 162 IVGALALNLLACGSLMRLFKNRVF--------------------------------------SALFIAIL--LFDIGAFP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 254 lPQVFLVPYAMWHRMDEQQAAL-LISIIGFSNIFLRPLAGLMAGRPAFAShrKYLFSLAFLLNGLTNLVCAASGDFWVLV 332
Cdd:cd17428 202 -PSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNS--LYLYVLTLIGMGAALLAIPFAKSYLTLA 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 333 GYCLVYSVsMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17428 279 VLSAILGF-LSGNWSIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLL 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-412 |
9.86e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 104.95 E-value: 9.86e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 6 ERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTML 85
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 86 GGVLASLGMVASSFSRNLSQLYFTAgFITGLGMCFSFQSSVTVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLE 164
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 165 DLGWRGTFLVFGgvflhccicgaimrpvatsvapetkecpppppetpALGCVAACGRTIqrhlafdilrhntGYCVYVLG 244
Cdd:COG2271 160 AFGWRAAFLILG-----------------------------------LPGLLLALLRFW-------------LLALAYFL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 245 VMWSILGFplpQVFLVPYAMWHR-MDEQQAALLISIIGFSNIFLRPLAGLMAGRpaFASHRKYLFSLAFLLNGLTNLVCA 323
Cdd:COG2271 192 VYFALYGF---LTWLPTYLVEVRgLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR--LGRRRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 324 ASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATnNFSYVFFMSSF 403
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAA 345
|
....*....
gi 967210437 404 FLISAALFM 412
Cdd:COG2271 346 LALLAALLA 354
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
14-412 |
2.99e-24 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 103.72 E-value: 2.99e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 14 WVVLLATMVTQGLTLGFPTCIGIFFTDLQWEF-----QASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGV 88
Cdd:cd17465 2 WVVVFAATWCNGSIFGIQNSFGILYVMLLNEQedqkdQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 89 LASLGMVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGW 168
Cdd:cd17465 82 VAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 169 RGTFLVFGGVFLhccicgaimrpvatsvapetkecpppppetpalgcvaacgRTIQRHLAFDILRHNTgYCVYVLGVMWS 248
Cdd:cd17465 162 AHTFQVLSLFMF----------------------------------------IQIFLSLTYKVFRRKT-YRIWAFGIATA 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 249 ILGFPLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMaGRPAFASHRKYLFSLAFLLNGLTNLVCAASGDF 328
Cdd:cd17465 201 VLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKI-GDLIPGLKKIYLQVASFLLLGIMSMMIPLCQVF 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 329 WVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISA 408
Cdd:cd17465 280 EGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIG 359
|
....
gi 967210437 409 ALFM 412
Cdd:cd17465 360 GTVL 363
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-410 |
4.43e-24 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 103.50 E-value: 4.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 13 AWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASL 92
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 93 GMVASSFSRNLSQLYFTAGFITGLGM-CFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGT 171
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAgTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 172 FLVFGGVflhcciCGAIMRPVATSVAPETKECPPPPPETPALGCVAACGRTIQRHLAFDILRHNTGYCVYVLGVMwsilg 251
Cdd:cd17355 161 LLVLALL------ALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGL----- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 252 fplpQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRpafaSHRKYLFSLAFLLNGLTNLVCAASG-DFWV 330
Cdd:cd17355 230 ----IVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR----YSPRRLLAASYALRALGLALLLLLPfPPLA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 331 LVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAAL 410
Cdd:cd17355 302 LLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-411 |
8.98e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 90.70 E-value: 8.98e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 2 PQALERADGSWAWVVLLATMVTQGLTLGFP-TCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCR 80
Cdd:COG2807 4 TSSSARRSRRAGRWLLLLAIVLVALNLRPAiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 81 VTTMLGGVLASLGMVASSFSRNLSQLYFTAGFItGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSR 160
Cdd:COG2807 84 RTLLLALLLLAAGLLLRSLAPSVALLLAGTALI-GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 161 YLLEDLGWRGTFLVFGGVFLHCCICGAIMRPVATSVApetkecpppppetpalgcvaacGRTIQRHLAFDILRHNTGYCV 240
Cdd:COG2807 163 PLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAA----------------------AAAPAAASLRSLWRSPLAWLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 241 YVLGVMWSILGFpLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRpafaSHRKYLFSLAFLLNGLTNL 320
Cdd:COG2807 221 TLFFGLQSLLYY-AVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADR----LGDRRPLLLLLGLLGLAGL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 321 VCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAF-LISPPLAGLLLDATNNFSYVFF 399
Cdd:COG2807 296 LGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLaALGPLLVGALHDATGSWTAALL 375
|
410
....*....|..
gi 967210437 400 MSSFFLISAALF 411
Cdd:COG2807 376 LLAALAVLMLVA 387
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
14-404 |
3.34e-18 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 85.93 E-value: 3.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 14 WVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLG 93
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 94 MVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFL 173
Cdd:cd17314 82 YTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 174 VFGGVFLHCCICGAIMRPVATSVAPETKECPPPPPETPAlgcvaacgrtiqrhlafDILRHNTGYCVYVLGVMWSILGFP 253
Cdd:cd17314 162 ILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMG-----------------EIFRDKVFWILFIAIFLVLIGGFL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 254 lPQVFLVPYAMWHRMDEQQ-AALLISIIGFSNIFLRPLAGLMAGrpaFASHRKYLFSLAFLLNGLT---NLVCAASGDFW 329
Cdd:cd17314 225 -FIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVAD---FFGGRLSTLSILLTILGLGlcaFLFLLKMTPVG 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967210437 330 VLVGYCLVYsVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFF 404
Cdd:cd17314 301 LVLTGSLLG-FSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVI 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-372 |
9.28e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 84.26 E-value: 9.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 8 ADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGG 87
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 88 VLASLGMVASSFSRNLSQLYFtAGFITGLGMCFSFQSSVTVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLEDL 166
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 167 GWRGTFLVFGGVFLHCCICGAIMRPVATSVApetkecpppppetpalgcvaacgRTIQRHLAFDILRHNTGYCVYVLGVM 246
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAA-----------------------RARLRGSLRELLRRPRLLLLLLLAFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 247 WSILGFPLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRpafaSHRKYLFSLAFLLNGLTNLVCAASG 326
Cdd:COG2814 219 LGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR----FGRRRLLLIGLLLLALGLLLLALAG 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 967210437 327 DFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVL 372
Cdd:COG2814 295 SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
13-410 |
9.32e-17 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 81.89 E-value: 9.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 13 AWVVLLATMVTQgLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASL 92
Cdd:cd17353 2 RWLVLLGAVLMH-LILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 93 GMVASSFSRNLSQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTF 172
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 173 LVFG-GVFLHCCICGAIMR-PVATSVAPETKECPPPPPETPALGCVAACGRTIQrhlaFDILrhntgYCVYVLGVMWSIL 250
Cdd:cd17353 161 LILGiIFLIIIVIGAFLIRdPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPT----FWLL-----WLMFFLNATAGLM 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 251 GFplpqVFLVPYAM-WHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfashRKYLFSLAFLLNGLTN--LVCAASGD 327
Cdd:cd17353 232 LI----GQAKPIGQeFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIG----RKNTLSIAFLIQGVAMflLPFIGSVA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 328 FWVLVGYCLVYSvSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGlLLDATNNFSYVF-FMSSFFLI 406
Cdd:cd17353 304 VLFVLGVALIGF-CYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFiIAAALSLV 381
|
....
gi 967210437 407 SAAL 410
Cdd:cd17353 382 ALAL 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-411 |
8.95e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 78.62 E-value: 8.95e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 34 IGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLYFtAGFI 113
Cdd:cd06174 15 ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL-GRFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 114 TGLGMCFSFQSSVTVLGFYFV-RRRVLANALASMGVSLGITLWPLLSRYLLE--DLGWRGTFLVFGGVFLHCCICGAIMR 190
Cdd:cd06174 94 LGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 191 PvatsvapetkecpppPPETPALGCVAACGRTIQRHLAFDILRHNTGYCVYVLGVMWSILGFPLPQVFLVPYAMWHRMDE 270
Cdd:cd06174 174 P---------------DPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 271 QQAALLISIIGFSNIFLRPLAGLMAGRPafaSHRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIF 350
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRL---IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 967210437 351 QVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALF 411
Cdd:cd06174 316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
44-381 |
3.19e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 73.61 E-value: 3.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 44 EFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLYFtAGFITGLGMCFSFQ 123
Cdd:pfam07690 26 DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV-LRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 124 SSVTVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLVFGGVFLHCCICGAIMRPVATSVAPetke 202
Cdd:pfam07690 105 AALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 203 cpppppetpalgcVAACGRTIQRHLAFDILRHNTGYCVYVLGVMWSIlGFPLPQVFLVPYAMWHRMDEQQAALLISIIGF 282
Cdd:pfam07690 181 -------------KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGF-AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 283 SNIFLRPLAGLMAGRPAFAShRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQF 362
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRR-RLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
|
330
....*....|....*....
gi 967210437 363 PRALGLFTVLDGFAFLISP 381
Cdd:pfam07690 326 GTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
44-412 |
8.04e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 8.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 44 EFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLYFTAgFITGLGMCFSFQ 123
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 124 SSVTVLG-FYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLVFGGVFLHCCICGAIMRPVATSVAPETKE 202
Cdd:cd17325 104 AAMALIAdIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 203 CPPPPPETPALgcvaacgrtiqrhlafdiLRHNTGYCVYVLGVMWSILGFPLPQVFLVPYAMWH-RMDEQQAALLISIIG 281
Cdd:cd17325 184 SAARLRSGLRL------------------LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 282 FSNIFLRPLAGLMAGRPAfashRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQ 361
Cdd:cd17325 246 LASALSQPPAGKLSDRIG----RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 967210437 362 FPRALGLFTVLDGFAFLISPPLAGLLLDaTNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17325 322 RGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-410 |
7.02e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 63.36 E-value: 7.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 32 TCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLYFtAG 111
Cdd:cd17319 20 VNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV-LR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 112 FITGLGMCFSFQSSVTVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLVFGgvflhccicgaimr 190
Cdd:cd17319 99 FLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEG-------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 191 pvatsvapetkecpppppetpALGCVAACgrtiqrhLAFDILRHNTGYCVYVLGVMWSILGFP--LPQVFLVPYAmwhrM 268
Cdd:cd17319 165 ---------------------LLGLLLAV-------LWWFYLRQVWGLALGYFGINYALYGLLtwLPTYLKQARG----F 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 269 DEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFsLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGAL 348
Cdd:cd17319 213 SLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVII-IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPV 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 967210437 349 IFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAAL 410
Cdd:cd17319 292 FWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAAL 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
242-412 |
7.04e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.29 E-value: 7.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 242 VLGVMWSILGFPLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRpafaSHRKYLFSLAFLLNGLTNLV 321
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR----FGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 322 CAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATnNFSYVFFMS 401
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWVFLVN 170
|
170
....*....|.
gi 967210437 402 SFFLISAALFM 412
Cdd:COG2814 171 AVLALLALLLL 181
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
55-412 |
8.78e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.20 E-value: 8.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 55 IPSILMAVLhmaGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLYFTAgFITGLGMCFSFQSSVTVLGFYFV 134
Cdd:cd17473 43 LPALFIALF---APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR-ALLGIGVAGIMTLATALIGDYFE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 135 -RRRVLANALASMGVSLGITLWPLLSRYLLEdLGWRGTFLVFG-GVFLHCCICGAIMRPVATSVAPetkecpppppetpa 212
Cdd:cd17473 119 gEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLlALPVLILVLLFLPEPARKSKSA-------------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 213 lgcvaacGRTIQRHLAFDILRHNTGYCVYVLGVMwsiLGFPLPQVFLvPYAMWHR--MDEQQAALLISIIGFSNIflrpL 290
Cdd:cd17473 184 -------ASPGAATAAALPWKRVLPIYFLAFLAM---LLFYVIPIQL-PFLLQERggGSAALIGLALAIASLAGA----I 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 291 AGLMAGRPAFASHRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFT 370
Cdd:cd17473 249 GALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVT 328
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 967210437 371 VLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17473 329 SAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
41-412 |
2.09e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.09 E-value: 2.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 41 LQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLyFTAGFITGLGM-C 119
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVL-LVLLFLVGAGYgS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 120 FSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLVFGGVflhcCICGAIM-------RPV 192
Cdd:cd17475 101 VQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV----SILAAVLfwlfyrePPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 193 ATSVAPETKECPppppetpalgcvaacgRTIQRHLAFDILRHntgycvyvlgVMWSILGFPLPQVFLVPYAM-----WHR 267
Cdd:cd17475 177 ASAATESASTLL----------------RSLKEVLRNRDVWL----------IAIAGALLVAPQFALLTFLLlflhdHLG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 268 MDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLAFL--LNGLTNLVCAASGDFWVLVGYCLVYSVSMSGI 345
Cdd:cd17475 231 LSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIaaAALLVLSLLSPGTPLWLLVLLLILLGLFAIGW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967210437 346 GALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17475 311 NGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-296 |
7.85e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.58 E-value: 7.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 4 ALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTT 83
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 84 MLGGVLASLGMVASSFSRNLSQLYFtAGFITGLGMCFSFQSSVTVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYL 162
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIA-ARALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 163 LEDLGWRGTFLVFGGVFLhccICGAIMRPVATSVAPETKECPPPPPETPALGCVAACGRTIQRHLAFDILRHNTGYCVYV 242
Cdd:COG0477 162 VAALGWRWIFLINAPLGL---LALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 967210437 243 LGVMWSILGFPLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAG 296
Cdd:COG0477 239 LLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
69-412 |
9.34e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 50.77 E-value: 9.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 69 LCSILVGRFGCRVTTMLGGVLASLGMVASSFSRN---LSQLYFTAGFITGLGMCFSfqsSVTVLGFYFVRRRVLANALAS 145
Cdd:cd06180 53 LASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGfaaLLALRFLAGAASAFVFVFG---SNLVLHHATAAGRGHLIGLLF 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 146 MGVSLGITLWPLL-SRYLLEDLGWRGTFLVFGGVFLHCCICGAIMRPVATSvapetkecpppppetpALGCVAACGRTIQ 224
Cdd:cd06180 130 AGVGLGIALSGLLvPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPS----------------APTEASAAESAPG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 225 RHLAFDILrhntgYCVYVLGVMwsilGFPLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFlrplAGLMAGRPAFASHR 304
Cdd:cd06180 194 LNRPLWRL-----ALAYGLFGF----GYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVP----SCFLWGALSDRWGT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 305 KYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQfPRALGLFTVLDGFAFLISPPLA 384
Cdd:cd06180 261 RRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAA-PRALALMTASFGVGQILGPLLA 339
|
330 340
....*....|....*....|....*...
gi 967210437 385 GLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd06180 340 GWLADATGGFAPALILAAAALVVAALLA 367
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
44-180 |
1.72e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.81 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 44 EFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLYFtAGFITGLGMCFSFQ 123
Cdd:cd17365 28 DWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMP 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 967210437 124 SSVTVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLVFGGVFL 180
Cdd:cd17365 107 NAITLVSEYApARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPL 164
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
26-411 |
1.74e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 26 LTLGFPTCI-GIFFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLS 104
Cdd:COG0738 18 FLWGFATALwGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 105 qLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLL---EDLGWRGTFLVFGGVFLH 181
Cdd:COG0738 98 -LLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLIllgLSLSWHLPYLILAVLLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 182 CCICGAIMR------PVATSVAPETKECPPPPPETPALGCVAACGrtiqrhlafdilrhntgyCVYVLGVMWSilgfplp 255
Cdd:COG0738 177 LALLFLRSKlpeieeEEEEAAGSAASLKSLLKNPRLLLGGLAIFL------------------YVGAEGAIGD------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 256 qvFLVPYAM-WHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRpaFASHRkyLFSLAFLLNGLTNLVCAASGDFWVLVGY 334
Cdd:COG0738 232 --WLPLYLKdVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR--FGPVR--LLRLSALLAAVGLLLALLAPGPWLALIG 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967210437 335 CLVYSVSMSGIGALIFQVLMDIVPMDQfPRALGLFTVLDGFAFLISPPLAGLLLDATnNFSYVFFMSSFFLISAALF 411
Cdd:COG0738 306 LALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLLILLL 380
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
44-411 |
2.34e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.39 E-value: 2.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 44 EFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLyFTAGFITGLGMCFSFQ 123
Cdd:cd17324 28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALL-LLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 124 SSVTVLGFYFV-RRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLVFGGVFLhcCICGAIMRPVATSVAPETKE 202
Cdd:cd17324 107 IAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL--LAALLLWRLLPSLPPKKPGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 203 CPPPPPETPALGcvaacgrtiQRHLAFDILRHNTGYCVYVlgVMWSILGFPLPQVFlvpyamwhRMDEQQAALLISIIGF 282
Cdd:cd17324 185 LGLLSSLLLLLR---------NPRLRLAYLITFLLFGGFF--ALYTYLAPFLTDVP--------GFSSSAIIGLLLLFGV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 283 SNIFLRPLAGLMAGRpafaSHRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPmDQF 362
Cdd:cd17324 246 AGVVGSPLAGRLADR----GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EAR 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 967210437 363 PRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALF 411
Cdd:cd17324 321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
83-411 |
3.36e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 3.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 83 TMLGGVLASLGMVASSFSRNLSQLYFTAgFITGLGMCFSFQSSVTVLGFYfVRRRVL--ANALASMGVSLGITLWPLLSR 160
Cdd:cd06173 72 LLRALLAAVLALLALLGSLSLWLLLVLA-FLLGIASAFFGPARQALLPEL-VPKEQLvrANALNSLATQLARIIGPALGG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 161 YLLEDLGWRGTFLVFGGVFLHCCICGAIMRPVATSVAPETKECPPPPPetpalgcvaacgrtiqRHLAFDILRHNTGYCV 240
Cdd:cd06173 150 LLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDL----------------REGLRYLRRSPLLRLL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 241 YVLGVMWSILGFPLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIflrpLAGLMAGRPAFASHRKYLFSLAFLLNGLTNL 320
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGAL----LGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 321 VCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATnNFSYVFFM 400
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL-GLSAVFLL 368
|
330
....*....|.
gi 967210437 401 SSFFLISAALF 411
Cdd:cd06173 369 AGALLLLAALL 379
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
38-174 |
4.35e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.64 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 38 FTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLY-------FTA 110
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIifrilqgFGG 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 967210437 111 GFITGLGMcfsfqssVTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLV 174
Cdd:cd17503 99 GVLIPLAQ-------TILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI 155
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
268-412 |
5.50e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 5.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 268 MDEQQAALLISIIGFSNIFLRPLAGLMAGRpafaSHRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGA 347
Cdd:pfam07690 29 ISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967210437 348 LIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATnNFSYVFFMSSFFLISAALFM 412
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAFLILAILSLLAAVLL 168
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
44-174 |
2.34e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 43.52 E-value: 2.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 44 EFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLYF---TAGFITGLGMCF 120
Cdd:TIGR00711 31 DLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIfrvIQGFGGGPLIPL 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 967210437 121 SFQssvTVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLV 174
Cdd:TIGR00711 111 SFS---TLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
40-174 |
2.40e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.32 E-value: 2.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 40 DLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLyFTAGFITGLGMC 119
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIGAA 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 967210437 120 FSFQSSVTVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLV 174
Cdd:cd17321 100 AIMPASLALIAATFpGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI 155
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
228-419 |
5.11e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 5.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 228 AFDILRHNTGYCVYVLGVMWSILGFPLPQVFLVPYAMWH-RMDEQQAALLISIIGFSNIFLRPLAGLMAGRpafaSHRKY 306
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKR----FGKKK 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 307 LFSLAFLLNGLTNLVCAASG--DFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPR-------ALGLFTVLDGFAF 377
Cdd:COG2211 296 AFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQ 375
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 967210437 378 LISPPLAGLLLDAT-------NNFSYVFFMSSFFLISAALFMGGSFYAL 419
Cdd:COG2211 376 ALAGALAGLLLALFgyvagaaQSPSALTGIRLLFFLLPAVLLLLAALLL 424
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
66-411 |
5.14e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 5.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 66 AGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSqLYFTAGFITGLGMCFSF---QSSVTVLGFYFVRRRVLAna 142
Cdd:cd17477 47 GSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-VWFLLRFVMGIGLAGLFvvsESWLNALATNENRGRVLG-- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 143 LASMGVSLGITLWPLLSRYLLEDlGWRgTFLVFGGVFLHCCICGAIMRPVATSVAPETKECPPPPPETPALGCVAACGrt 222
Cdd:cd17477 124 LYSTVLGLGFALGPLLLALVGTA-GAL-PFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFV-- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 223 iqrhlafdilrhntgyCVYVLGVMWSILgfPLpqvflvpYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRpafAS 302
Cdd:cd17477 200 ----------------AGFLEGAFYSLL--PL-------YGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADR---FD 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 303 HRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPP 382
Cdd:cd17477 252 RRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPL 331
|
330 340
....*....|....*....|....*....
gi 967210437 383 LAGLLLDATNNFSYVFFMSSFFLISAALF 411
Cdd:cd17477 332 LAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
248-429 |
5.75e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 5.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 248 SILGFPLPQVFLVPYAMWHRMDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfashRKYLFSLAFLLNGLTNLVCAASGD 327
Cdd:cd17489 8 FFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFG----RKRLLLIGLLIFALATLLYLLATS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 328 FWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDaTNNFSYVFFMSSFFLIS 407
Cdd:cd17489 84 VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ-HLGFAVLFIVAAVLALL 162
|
170 180
....*....|....*....|..
gi 967210437 408 AALFMGGSFYALQKKEQGKRAV 429
Cdd:cd17489 163 ALLLVFLVKDPPPVAAEEAEAG 184
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
290-412 |
6.11e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.76 E-value: 6.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 290 LAGLMAGRPAFASHRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLF 369
Cdd:cd17370 249 LAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLF 328
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 967210437 370 TVLDGFAFLISPPLAGLLLDaTNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17370 329 NTVVGIGWLLASLIAGYLWD-LISPSAAFLFSAVLALIALLLL 370
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
66-176 |
1.66e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 38.78 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 66 AGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLYFtAGFITGLGMCFSFQSSVTVLG-FYFVRRRVLANALA 144
Cdd:TIGR00880 14 YSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII-ARFLQGFGAAFALVAGAALIAdIYPPEERGVALGLM 92
|
90 100 110
....*....|....*....|....*....|..
gi 967210437 145 SMGVSLGITLWPLLSRYLLEDLGWRGTFLVFG 176
Cdd:TIGR00880 93 SAGIALGPLLGPPLGGVLAQFLGWRAPFLFLA 124
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
44-412 |
2.00e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 44 EFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSqLYFTAGFITGLGMCFSFQ 123
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 124 SSVTVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLVFGGVFLHCCICGAIMRPVATSvapetke 202
Cdd:cd17489 104 AAATLVADIIpPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPV------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 203 cpppppetpalgcVAACGRTIQRHLAFDILRHNTgycVYVLGVMWSILGFPLPQVFLVPYAMWHRMDeqQAALLISIIGF 282
Cdd:cd17489 177 -------------AAEEAEAGTRAFRRLVEKKVL---PPALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 283 SNIFLRPLAGLMAGRPafasHRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMsGIGALIFQVLM-DIVPMDQ 361
Cdd:cd17489 239 ALLLSRPFSGKLSDRK----GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF-GLLFPALQALAvDLVPPHR 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 967210437 362 FPRALGLFTVLDGFAFLISPPLAGLLLDATnNFSYVFFMSSFFLISAALFM 412
Cdd:cd17489 314 RGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
268-412 |
3.39e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.45 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 268 MDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfashRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGA 347
Cdd:cd17324 31 VSVAQAGLLVSAYALGYALGALLLGPLSDRIE----RRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967210437 348 LIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATnNFSYVFFMSSFFLISAALFM 412
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-GWRAAFLAIAVLALLAALLL 170
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
45-410 |
4.88e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 4.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 45 FQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLyFTAGFITGLGMCFSFQS 124
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILL-LVLRFLQGIGIGGEYPG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 125 SVTVLG-FYFVRRRVLANALASMGVSLGITL----WPLLSRYLLEDLGWRGTFLVfggvflhccicGAIMRPVATsvape 199
Cdd:cd17316 110 ASTYVAeFAPSKRRGFALGLLQSGWALGALLaalvASLLIPLLSGDWGWRILFLI-----------GALPALLAL----- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 200 tkecpppppetpalgcvaacgrtiqrhlafdILRHNTGYCVyVLGVMWSILGFPLPQVFLVPYAMWHRMDEQQAALLISI 279
Cdd:cd17316 174 -------------------------------LLRRRTLLLI-LLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 280 IGFSNIFLRPLAGLMAGRpaFASHRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPM 359
Cdd:cd17316 222 ISLGALVGALIAGLLSDR--IGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPT 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 967210437 360 DQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAAL 410
Cdd:cd17316 300 EVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
38-178 |
5.75e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 38.72 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 38 FTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLyFTAGFITGLG 117
Cdd:PRK11043 29 FKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQL-LVLRFVQAVG 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 967210437 118 MC---FSFQSSVTVLGFYFVRRRVLANALASmgVSLGITLWPLLSRYLLEDLGWRGTFLVFGGV 178
Cdd:PRK11043 108 VCsaaVIWQALVIDRYPAQKANRVFATIMPL--VALSPALAPLLGAWLLNHFGWQAIFATLFAI 169
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
304-412 |
5.77e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 5.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 304 RKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGFAFLISPPL 383
Cdd:cd17503 60 TRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTL 139
|
90 100
....*....|....*....|....*....
gi 967210437 384 AGLLLDATnNFSYVFFMSSFFLISAALFM 412
Cdd:cd17503 140 GGWLTDNL-SWRWIFYINLPIGILALLLA 167
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
37-412 |
5.92e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 5.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 37 FFTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLYFtAGFITGL 116
Cdd:cd17330 21 FYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFL-ARFLDGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 117 GM-----CFSFQSSVTVlgfyfVRRRVLANALASMGVSLGITLWPLLSRYLLEDLGWRGTFLVFGGV-FLHCCICGAIMR 190
Cdd:cd17330 100 TGgnvsvAQAYIADITD-----EEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALaLLNLVLVLFFLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 191 PVatsvapetkecppppPETPALGCVAACgrtiqrhlafdilrhntgycvyVLGVMWSILGFPLPQVFlvpyamwhRMDE 270
Cdd:cd17330 175 PL---------------RRLLLVYFLIAL----------------------AFAGLESVFSLFLKDRF--------GFSP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 271 QQAALLISIIGFSNIFLRplaGLMAGRPAFASHRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIF 350
Cdd:cd17330 210 SQIGLLLALVGIAGILAQ---LLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALS 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 967210437 351 QVLMDIVPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17330 287 ALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-172 |
6.52e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 6.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 18 LATMVTQGLTLGFPTCIGIFFTDLQWEFQASnSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVAS 97
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 967210437 98 SFSRNLSQLYFTAGFI-TGLGMCFSFQSSVTVLgfYFVRRRVLANALASMGVSLGITLWPLLSRYLLE--DLGWRGTF 172
Cdd:cd06179 80 GTAKSVNMLIGGQALIgIGAGTQGLGAAVASEL--VPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIF 155
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
38-412 |
7.08e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 7.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 38 FTDLQWEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFGCRVTTMLGGVLASLGMVASSFSRNLSQLYFtAGFITGLG 117
Cdd:cd17474 22 LPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA-GRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 118 MCFSFQSSVTVLG-FYFVRRRVLANALASMGVSLGITLWPLLSRYLLeDLGWRGTFLVFGGVFLHCCICGAIMRPVATSV 196
Cdd:cd17474 101 AAGLGPLALTLIGdLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 197 APETKEcpppppetpalgcvaacgrTIQRHLAFdILRHNTGYCVYVLGVMWSILGFPLPQVFLVPYAMWHRMDEQQAALL 276
Cdd:cd17474 180 AKSSSA-------------------TKLRDLKK-ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 277 ISIIGFSNIFLRPLAGLMAGRpafASHRKYLFSLAFLLNGLTNLVCAASGDFWVLVGYCLVYSVSMSGIGALIFQVLMDI 356
Cdd:cd17474 240 FAGWSVLLALGSLFVGRLLKK---RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTEL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 967210437 357 VPMDQFPRALGLFTVLDGFAFLISPPLAGLLLDATNNFSYVFFMSSFFLISAALFM 412
Cdd:cd17474 317 APEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-191 |
7.50e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 7.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 14 WVVLLATMVTQGLTLGFPTCIGIFFTDlqwEFQASNSQTSWIPSILMAVLHMAGPLCSILVGRFG--CRVTTMLGGVLAS 91
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVE---VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967210437 92 LGMVASSFSRNLsQLYFTAGFITGLGMCFSFQSSVTVLGFYFVRRRV-LANALASMGVSLGITLWPLLSRYLLEDLGWRG 170
Cdd:COG2271 260 LALLLLALLPSP-ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARgTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 967210437 171 TFLVFGGVFLHCCICGAIMRP 191
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| |
