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Conserved domains on  [gi|966991412|ref|XP_014972620|]
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transmembrane protein 245 isoform X1 [Macaca mulatta]

Protein Classification

AI-2E family transporter( domain architecture ID 10001851)

AI-2E family transporter similar to Escherichia coli PerM which may function as a permease

Gene Ontology:  GO:1905887|GO:0015562|GO:0055085
PubMed:  20559013|35698912
TCDB:  2.A.86

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PerM COG0628
Predicted PurR-regulated permease PerM [General function prediction only];
649-841 2.37e-14

Predicted PurR-regulated permease PerM [General function prediction only];


:

Pssm-ID: 440393  Cd Length: 346  Bit Score: 75.26  E-value: 2.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412 649 SGTALLNFVLSLIIFLTTLFYLLSSSDEYykpVKWVISLTPLSqPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWL 728
Cdd:COG0628  143 LLSSLGGLLLNLVLVLILLFFLLLDGDRL---RRWLLRLLPLR-YRERVRRLLREIDRTLGGYLRGQLLVALIVGVLTGI 218
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412 729 THTIFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLdLWLTQGLGcKAILLLIF----HLLPTYFVDTAIYSDiSGGGH 804
Cdd:COG0628  219 GLLILGVPYALLLGVLAGLLNFIPYVGPILGAIPAAL-VALLQGPG-LALLVLIVylvvQQLEGNVLRPKLVGR-SVGLH 295
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 966991412 805 PYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIY 841
Cdd:COG0628  296 PLVVLLALLGGGALFGILGLFLAPPLAAVLKVLLREL 332
 
Name Accession Description Interval E-value
PerM COG0628
Predicted PurR-regulated permease PerM [General function prediction only];
649-841 2.37e-14

Predicted PurR-regulated permease PerM [General function prediction only];


Pssm-ID: 440393  Cd Length: 346  Bit Score: 75.26  E-value: 2.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412 649 SGTALLNFVLSLIIFLTTLFYLLSSSDEYykpVKWVISLTPLSqPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWL 728
Cdd:COG0628  143 LLSSLGGLLLNLVLVLILLFFLLLDGDRL---RRWLLRLLPLR-YRERVRRLLREIDRTLGGYLRGQLLVALIVGVLTGI 218
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412 729 THTIFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLdLWLTQGLGcKAILLLIF----HLLPTYFVDTAIYSDiSGGGH 804
Cdd:COG0628  219 GLLILGVPYALLLGVLAGLLNFIPYVGPILGAIPAAL-VALLQGPG-LALLVLIVylvvQQLEGNVLRPKLVGR-SVGLH 295
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 966991412 805 PYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIY 841
Cdd:COG0628  296 PLVVLLALLGGGALFGILGLFLAPPLAAVLKVLLREL 332
AI-2E_transport pfam01594
AI-2E family transporter; This family includes four different proteins from E. coli alone. One ...
604-841 2.31e-09

AI-2E family transporter; This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA, has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration of AI-2, TqsA affects gene expression in biofilms and biofilm formation. TsqA belongs to the AI-2 exporter (AI-2E) superfamily.


Pssm-ID: 279875  Cd Length: 327  Bit Score: 59.94  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412  604 QDIASFVHENIETFLSILESLWIVMSRNVSLLFTTVTTLLTILFYSgtaLLNFVLSLIIFLTTLFYLLSSSDEYykpVKW 683
Cdd:pfam01594  94 LNILNELPSLLPELYNNIQQLNQSLSDILSNILSSILNSLLSLLAS---ITGLILSLVLVLLLTFYFLLDGERL---RQG 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412  684 VISLTPLSQPGPSSNIIGQSvEEAIRGVFDASLKMAGFYGLYTWLTHTIFGINIVFIPSALAAILGAVPFLGTYWAAVPA 763
Cdd:pfam01594 168 IIRFLPSRYRERVDAILREI-NQTLGGYLRGQFLVALIIGVATFIGLLILGVPYALLLAILVGLANLIPYIGPVIALIPI 246
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412  764 VLDLWLTQGLGcKAILLLIFHLLPTYFVDTAIYSDISG---GGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNI 840
Cdd:pfam01594 247 AIIALLTGGIW-EGLIVLIVVLLVQQIEGNILRPKLMGkrlGLHPLVILLSLLAGGSLFGLVGLILAVPLTAVIKAILEA 325

                  .
gi 966991412  841 Y 841
Cdd:pfam01594 326 Y 326
 
Name Accession Description Interval E-value
PerM COG0628
Predicted PurR-regulated permease PerM [General function prediction only];
649-841 2.37e-14

Predicted PurR-regulated permease PerM [General function prediction only];


Pssm-ID: 440393  Cd Length: 346  Bit Score: 75.26  E-value: 2.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412 649 SGTALLNFVLSLIIFLTTLFYLLSSSDEYykpVKWVISLTPLSqPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWL 728
Cdd:COG0628  143 LLSSLGGLLLNLVLVLILLFFLLLDGDRL---RRWLLRLLPLR-YRERVRRLLREIDRTLGGYLRGQLLVALIVGVLTGI 218
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412 729 THTIFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLdLWLTQGLGcKAILLLIF----HLLPTYFVDTAIYSDiSGGGH 804
Cdd:COG0628  219 GLLILGVPYALLLGVLAGLLNFIPYVGPILGAIPAAL-VALLQGPG-LALLVLIVylvvQQLEGNVLRPKLVGR-SVGLH 295
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 966991412 805 PYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIY 841
Cdd:COG0628  296 PLVVLLALLGGGALFGILGLFLAPPLAAVLKVLLREL 332
AI-2E_transport pfam01594
AI-2E family transporter; This family includes four different proteins from E. coli alone. One ...
604-841 2.31e-09

AI-2E family transporter; This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA, has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration of AI-2, TqsA affects gene expression in biofilms and biofilm formation. TsqA belongs to the AI-2 exporter (AI-2E) superfamily.


Pssm-ID: 279875  Cd Length: 327  Bit Score: 59.94  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412  604 QDIASFVHENIETFLSILESLWIVMSRNVSLLFTTVTTLLTILFYSgtaLLNFVLSLIIFLTTLFYLLSSSDEYykpVKW 683
Cdd:pfam01594  94 LNILNELPSLLPELYNNIQQLNQSLSDILSNILSSILNSLLSLLAS---ITGLILSLVLVLLLTFYFLLDGERL---RQG 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412  684 VISLTPLSQPGPSSNIIGQSvEEAIRGVFDASLKMAGFYGLYTWLTHTIFGINIVFIPSALAAILGAVPFLGTYWAAVPA 763
Cdd:pfam01594 168 IIRFLPSRYRERVDAILREI-NQTLGGYLRGQFLVALIIGVATFIGLLILGVPYALLLAILVGLANLIPYIGPVIALIPI 246
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966991412  764 VLDLWLTQGLGcKAILLLIFHLLPTYFVDTAIYSDISG---GGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNI 840
Cdd:pfam01594 247 AIIALLTGGIW-EGLIVLIVVLLVQQIEGNILRPKLMGkrlGLHPLVILLSLLAGGSLFGLVGLILAVPLTAVIKAILEA 325

                  .
gi 966991412  841 Y 841
Cdd:pfam01594 326 Y 326
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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