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Conserved domains on  [gi|1622868247|ref|XP_014972446|]
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toll-like receptor 4 isoform X1 [Macaca mulatta]

Protein Classification

toll/interleukin-1 receptor domain-containing protein( domain architecture ID 13320293)

toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Gallus gallus toll-like receptor 15; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats similar to Gallus gallus toll-like receptor 2; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR); toll/interleukin-1 receptor (TIR) domain-containing protein with leucine-rich repeats such as Rattus norvegicus toll-like receptor 4; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
634-775 1.04e-33

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 125.90  E-value: 1.04e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  634 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 713
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622868247  714 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGQhiFWRRLRKAL 775
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
293-561 5.70e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 5.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 293 QHLELVNCKFEQFPTlELESLKRLTfTANKGGNAFSEV-----DLPSLEFLDLSKNGLSfkgCCSQSDFGTTSLKYLDLS 367
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELANLTNLK-ELDLSNNQLTDLpeplgNLTNLKSLDLSNNQLT---DLPEELGNLTNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 368 FNDVITMSSNFLGLEKLEHLDFQHSNLKQMSqfSVFLSLRNLIYLDISHThtRVAFNGIFDGLLSLKVLKMAGNSFQEnf 447
Cdd:COG4886   191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLTD-- 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 448 LPDIFtDLKNLTFLDLSQCQLEQLSPTAFDTLNKLQVLNMSHNNFFSLDTFPYKCLPSLQVLDYSLNHIMTSNNQELQHF 527
Cdd:COG4886   265 LPPLA-NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1622868247 528 PSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLL 561
Cdd:COG4886   344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 7-492 8.49e-09

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 8.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247   7 KIPDNI---PFSTKNLDLSFNPLRhlGSYSFLRFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFS 83
Cdd:PLN00113  108 PIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  84 GLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIqSFKLPEYFSNLTNLEHLDLSSNKIQNIYCKDLQVLHQMPL 163
Cdd:PLN00113  186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQY 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 164 SNLSLDLSLNPInfiQPGAFKEIRLHKLTLRSNFDDLNVMKTCIQgLAGLEVHRLvlgeFRNErnleeFDKSSLEGLCNL 243
Cdd:PLN00113  265 LFLYQNKLSGPI---PPSIFSLQKLISLDLSDNSLSGEIPELVIQ-LQNLEILHL----FSNN-----FTGKIPVALTSL 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 244 TieefRLTYLDYYLDNiidlfncLANVSSFSLVSVSIKRVEDFSYNFRWQHLELVNCKFEQFPTLEL------------- 310
Cdd:PLN00113  332 P----RLQVLQLWSNK-------FSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILfsnslegeipksl 400

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 311 ---ESLKRLTFTANKGGNAFSE--VDLPSLEFLDLSKNGLSfkGCCSQSDFGTTSLKYLDLSFNDVITMSSNFLGLEKLE 385
Cdd:PLN00113  401 gacRSLRRVRLQDNSFSGELPSefTKLPLVYFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLE 478

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 386 HLDFQHSNLKQMSQFSvFLSLRNLIYLDISHTHtrvaFNGIFDGLLS----LKVLKMAGNSFQENfLPDIFTDLKNLTFL 461
Cdd:PLN00113  479 NLDLSRNQFSGAVPRK-LGSLSELMQLKLSENK----LSGEIPDELSsckkLVSLDLSHNQLSGQ-IPASFSEMPVLSQL 552

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1622868247 462 DLSQCQLEQLSPTAFDTLNKLQVLNMSHNNF 492
Cdd:PLN00113  553 DLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRRCT smart00082
Leucine rich repeat C-terminal domain;
539-585 2.21e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.11  E-value: 2.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622868247  539 NDFACTCEHQSFLQWIKDQRQLLVEaERMECATPSDKQGmPVLSLNI 585
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDP-VDLRCASPSSLRG-PLLELLH 45
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
634-775 1.04e-33

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 125.90  E-value: 1.04e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  634 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 713
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622868247  714 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGQhiFWRRLRKAL 775
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-776 2.69e-32

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 122.86  E-value: 2.69e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 637 FVIYSS----QDEDWVRNELVKNLeeGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYE 712
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 713 IAQTWQfLSSRAGIIFIVLQKVEK-------TLLRQQVELYRLLSRNTYLEWE------------DSVLGQHIFWRRLRK 773
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156


                  ...
gi 1622868247 774 ALL 776
Cdd:pfam01582 157 DIS 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
293-561 5.70e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 5.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 293 QHLELVNCKFEQFPTlELESLKRLTfTANKGGNAFSEV-----DLPSLEFLDLSKNGLSfkgCCSQSDFGTTSLKYLDLS 367
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELANLTNLK-ELDLSNNQLTDLpeplgNLTNLKSLDLSNNQLT---DLPEELGNLTNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 368 FNDVITMSSNFLGLEKLEHLDFQHSNLKQMSqfSVFLSLRNLIYLDISHThtRVAFNGIFDGLLSLKVLKMAGNSFQEnf 447
Cdd:COG4886   191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLTD-- 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 448 LPDIFtDLKNLTFLDLSQCQLEQLSPTAFDTLNKLQVLNMSHNNFFSLDTFPYKCLPSLQVLDYSLNHIMTSNNQELQHF 527
Cdd:COG4886   265 LPPLA-NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1622868247 528 PSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLL 561
Cdd:COG4886   344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 7-492 8.49e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 8.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247   7 KIPDNI---PFSTKNLDLSFNPLRhlGSYSFLRFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFS 83
Cdd:PLN00113  108 PIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  84 GLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIqSFKLPEYFSNLTNLEHLDLSSNKIQNIYCKDLQVLHQMPL 163
Cdd:PLN00113  186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQY 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 164 SNLSLDLSLNPInfiQPGAFKEIRLHKLTLRSNFDDLNVMKTCIQgLAGLEVHRLvlgeFRNErnleeFDKSSLEGLCNL 243
Cdd:PLN00113  265 LFLYQNKLSGPI---PPSIFSLQKLISLDLSDNSLSGEIPELVIQ-LQNLEILHL----FSNN-----FTGKIPVALTSL 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 244 TieefRLTYLDYYLDNiidlfncLANVSSFSLVSVSIKRVEDFSYNFRWQHLELVNCKFEQFPTLEL------------- 310
Cdd:PLN00113  332 P----RLQVLQLWSNK-------FSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILfsnslegeipksl 400

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 311 ---ESLKRLTFTANKGGNAFSE--VDLPSLEFLDLSKNGLSfkGCCSQSDFGTTSLKYLDLSFNDVITMSSNFLGLEKLE 385
Cdd:PLN00113  401 gacRSLRRVRLQDNSFSGELPSefTKLPLVYFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLE 478

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 386 HLDFQHSNLKQMSQFSvFLSLRNLIYLDISHTHtrvaFNGIFDGLLS----LKVLKMAGNSFQENfLPDIFTDLKNLTFL 461
Cdd:PLN00113  479 NLDLSRNQFSGAVPRK-LGSLSELMQLKLSENK----LSGEIPDELSsckkLVSLDLSHNQLSGQ-IPASFSEMPVLSQL 552

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1622868247 462 DLSQCQLEQLSPTAFDTLNKLQVLNMSHNNF 492
Cdd:PLN00113  553 DLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
17-74 8.56e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 8.56e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622868247  17 KNLDLSFNPLRHLGSYSFLRFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPI 74
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-150 1.58e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247   3 LKFYKIPDNIPFSTKNLDLSFNPLRHLGSYSFLRFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPiqslalgAF 82
Cdd:COG4886    37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------EL 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622868247  83 SGLSSLQKLVAVETNLASLENFpIGHLKTLKELNVAHNLIQSfkLPEYFSNLTNLEHLDLSSNKIQNI 150
Cdd:COG4886   110 SNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDL 174
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 359-518 2.56e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 2.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 359 TSLKYLDLsFNDVITMSSNFLGLEKLEHLDFQHSNLKQMSQFSvflSLRNLIYLDISHTHTRVAFNgiFDGLLSLKVLKM 438
Cdd:cd21340    24 KNLKVLYL-YDNKITKIENLEFLTNLTHLYLQNNQIEKIENLE---NLVNLKKLYLGGNRISVVEG--LENLTNLEELHI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 439 AGNSFQEN----FLPD-IFTDLKNLTFLDLSQCQLEQLSPtaFDTLNKLQVLNMSHNNFFSLD--TFPYKCLPSLQVLDY 511
Cdd:cd21340    98 ENQRLPPGekltFDPRsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDL 175


                  ....*..
gi 1622868247 512 SLNHIMT 518
Cdd:cd21340   176 TGNPVCK 182
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-162 2.88e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 2.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  37 FPELQVLDLSRCEIQTIEDgaYQSLSHLSTLILTGNPIQSLalGAFSGLSSLQKL------VAVETNLASLENF------ 104
Cdd:cd21340    23 CKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLylggnrISVVEGLENLTNLeelhie 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622868247 105 ----PIGH------------LKTLKELNVAHNLIQSfklPEYFSNLTNLEHLDLSSNKIQNIycKDL-QVLHQMP 162
Cdd:cd21340    99 nqrlPPGEkltfdprslaalSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDL--EELlDLLSSWP 168
LRRCT smart00082
Leucine rich repeat C-terminal domain;
539-585 2.21e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.11  E-value: 2.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622868247  539 NDFACTCEHQSFLQWIKDQRQLLVEaERMECATPSDKQGmPVLSLNI 585
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDP-VDLRCASPSSLRG-PLLELLH 45
LRR_8 pfam13855
Leucine rich repeat;
432-492 1.56e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622868247 432 SLKVLKMAGNSFQeNFLPDIFTDLKNLTFLDLSQCQLEQLSPTAFDTLNKLQVLNMSHNNF 492
Cdd:pfam13855   2 NLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 312-509 5.79e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 5.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 312 SLKRLTFTANKGGNAFSEVDLPSLEFLDLSKNGLSFKgccSQSDFGT-TSLKYLDLSFNDVITMSSNFLG-LEKLEHLDF 389
Cdd:PLN00113  119 SLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGE---IPNDIGSfSSLKVLDLGGNVLVGKIPNSLTnLTSLEFLTL 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 390 QH--------SNLKQMSQFS-VFLSLRNL---IYLDI----SHTHTRVAFNGI-------FDGLLSLKVLKMAGNSFQEN 446
Cdd:PLN00113  196 ASnqlvgqipRELGQMKSLKwIYLGYNNLsgeIPYEIggltSLNHLDLVYNNLtgpipssLGNLKNLQYLFLYQNKLSGP 275

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622868247 447 FLPDIFtDLKNLTFLDLSQCQLEQLSPTAFDTLNKLQVLNMSHNNFFSLDTFPYKCLPSLQVL 509
Cdd:PLN00113  276 IPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL 337
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
634-775 1.04e-33

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 125.90  E-value: 1.04e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  634 YDAFVIYSSQDedWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEI 713
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEI-DEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622868247  714 AQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNtYLEWEDSVLGQhiFWRRLRKAL 775
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN-YLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-776 2.69e-32

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 122.86  E-value: 2.69e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 637 FVIYSS----QDEDWVRNELVKNLeeGVPPFQLCLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYE 712
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 713 IAQTWQfLSSRAGIIFIVLQKVEK-------TLLRQQVELYRLLSRNTYLEWE------------DSVLGQHIFWRRLRK 773
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156


                  ...
gi 1622868247 774 ALL 776
Cdd:pfam01582 157 DIS 159
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 637-732 5.27e-13

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 66.18  E-value: 5.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 637 FVIYSSQDEDWVRnELVKNLEE-GVPPFqlcLHYRDFIPGVAIAANIiHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAq 715
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAaGYRVW---LDRWDIRPGDDWVEEI-EEAIENSDRVLVVLSPNYLESPWCRAEWEAA- 75

                          90
                  ....*....|....*..
gi 1622868247 716 tWQFLSSRAGIIFIVLQ 732
Cdd:pfam13676  76 -LADPEGRKRLIPVRLE 91
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
293-561 5.70e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 5.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 293 QHLELVNCKFEQFPTlELESLKRLTfTANKGGNAFSEV-----DLPSLEFLDLSKNGLSfkgCCSQSDFGTTSLKYLDLS 367
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELANLTNLK-ELDLSNNQLTDLpeplgNLTNLKSLDLSNNQLT---DLPEELGNLTNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 368 FNDVITMSSNFLGLEKLEHLDFQHSNLKQMSqfSVFLSLRNLIYLDISHThtRVAFNGIFDGLLSLKVLKMAGNSFQEnf 447
Cdd:COG4886   191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLTD-- 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 448 LPDIFtDLKNLTFLDLSQCQLEQLSPTAFDTLNKLQVLNMSHNNFFSLDTFPYKCLPSLQVLDYSLNHIMTSNNQELQHF 527
Cdd:COG4886   265 LPPLA-NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1622868247 528 PSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLL 561
Cdd:COG4886   344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 7-492 8.49e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 8.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247   7 KIPDNI---PFSTKNLDLSFNPLRhlGSYSFLRFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFS 83
Cdd:PLN00113  108 PIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  84 GLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIqSFKLPEYFSNLTNLEHLDLSSNKIQNIYCKDLQVLHQMPL 163
Cdd:PLN00113  186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQY 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 164 SNLSLDLSLNPInfiQPGAFKEIRLHKLTLRSNFDDLNVMKTCIQgLAGLEVHRLvlgeFRNErnleeFDKSSLEGLCNL 243
Cdd:PLN00113  265 LFLYQNKLSGPI---PPSIFSLQKLISLDLSDNSLSGEIPELVIQ-LQNLEILHL----FSNN-----FTGKIPVALTSL 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 244 TieefRLTYLDYYLDNiidlfncLANVSSFSLVSVSIKRVEDFSYNFRWQHLELVNCKFEQFPTLEL------------- 310
Cdd:PLN00113  332 P----RLQVLQLWSNK-------FSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILfsnslegeipksl 400

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 311 ---ESLKRLTFTANKGGNAFSE--VDLPSLEFLDLSKNGLSfkGCCSQSDFGTTSLKYLDLSFNDVITMSSNFLGLEKLE 385
Cdd:PLN00113  401 gacRSLRRVRLQDNSFSGELPSefTKLPLVYFLDISNNNLQ--GRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLE 478

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 386 HLDFQHSNLKQMSQFSvFLSLRNLIYLDISHTHtrvaFNGIFDGLLS----LKVLKMAGNSFQENfLPDIFTDLKNLTFL 461
Cdd:PLN00113  479 NLDLSRNQFSGAVPRK-LGSLSELMQLKLSENK----LSGEIPDELSsckkLVSLDLSHNQLSGQ-IPASFSEMPVLSQL 552

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1622868247 462 DLSQCQLEQLSPTAFDTLNKLQVLNMSHNNF 492
Cdd:PLN00113  553 DLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
17-74 8.56e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 8.56e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622868247  17 KNLDLSFNPLRHLGSYSFLRFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPI 74
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
319-516 1.04e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 319 TANKGGNAFSEVDLPSLEFLDLSKNGLSFKGCCSQSDFGTTSLKYLDLSFNDVITMSSNFLGLEKLEHLDFQHSNLKQMS 398
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 399 QFSVFLSLRNLIYLDISHthtrvafNGIFDGLLSLKVLKMAGNSFQEnfLPDIFTDLKNLTFLDLSQCQLEQLsPTAFDT 478
Cdd:COG4886    88 GLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDL-PEPLGN 157

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1622868247 479 LNKLQVLNMSHNNFFSLDTFPYKcLPSLQVLDYSLNHI 516
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQI 194
LRR_8 pfam13855
Leucine rich repeat;
38-91 1.24e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.24e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622868247  38 PELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKL 91
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-150 1.58e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247   3 LKFYKIPDNIPFSTKNLDLSFNPLRHLGSYSFLRFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPiqslalgAF 82
Cdd:COG4886    37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------EL 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622868247  83 SGLSSLQKLVAVETNLASLENFpIGHLKTLKELNVAHNLIQSfkLPEYFSNLTNLEHLDLSSNKIQNI 150
Cdd:COG4886   110 SNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDL 174
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-463 1.89e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  29 LGSYSFLRFPELQVLDLSRCEiqtiedgAYQSLSHLSTLILTGNPIQSLALgAFSGLSSLQKLVAVETNLASLENfPIGH 108
Cdd:COG4886    87 LGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGN 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 109 LKTLKELNVAHNLIQSfkLPEYFSNLTNLEHLDLSSNKIQNIyckdlqvlhqmplsnlsldlslnpinfiqPGAFKEI-R 187
Cdd:COG4886   158 LTNLKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDL-----------------------------PEPLGNLtN 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 188 LHKLTLRSNfddlnvmktciqglaglevhrlvlgefrnerNLEEFDkSSLEGLCNLTieefrltyldyyldniidlfncl 267
Cdd:COG4886   207 LEELDLSGN-------------------------------QLTDLP-EPLANLTNLE----------------------- 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 268 anvssfslvsvsikrvedfsynfrwqHLELVNCKFEQFPTL-ELESLKRLTFTANKGGNAFSEVDLPSLEFLDLSKNGLS 346
Cdd:COG4886   232 --------------------------TLDLSNNQLTDLPELgNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 347 FKGCCSQSDFGTTSLKYLDLSFNDVITMSSNFLGLEKLEHLDFQHSNLKQMSQFSVFLSLRNLIYLDISHTHTRVAFNGI 426
Cdd:COG4886   286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1622868247 427 FDGLLSLKVLKMAGNSFQENFLPDIFTDLKNLTFLDL 463
Cdd:COG4886   366 LLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 359-518 2.56e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 2.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 359 TSLKYLDLsFNDVITMSSNFLGLEKLEHLDFQHSNLKQMSQFSvflSLRNLIYLDISHTHTRVAFNgiFDGLLSLKVLKM 438
Cdd:cd21340    24 KNLKVLYL-YDNKITKIENLEFLTNLTHLYLQNNQIEKIENLE---NLVNLKKLYLGGNRISVVEG--LENLTNLEELHI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 439 AGNSFQEN----FLPD-IFTDLKNLTFLDLSQCQLEQLSPtaFDTLNKLQVLNMSHNNFFSLD--TFPYKCLPSLQVLDY 511
Cdd:cd21340    98 ENQRLPPGekltFDPRsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDL 175


                  ....*..
gi 1622868247 512 SLNHIMT 518
Cdd:cd21340   176 TGNPVCK 182
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-162 2.88e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 2.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  37 FPELQVLDLSRCEIQTIEDgaYQSLSHLSTLILTGNPIQSLalGAFSGLSSLQKL------VAVETNLASLENF------ 104
Cdd:cd21340    23 CKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLylggnrISVVEGLENLTNLeelhie 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622868247 105 ----PIGH------------LKTLKELNVAHNLIQSfklPEYFSNLTNLEHLDLSSNKIQNIycKDL-QVLHQMP 162
Cdd:cd21340    99 nqrlPPGEkltfdprslaalSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDL--EELlDLLSSWP 168
LRR_8 pfam13855
Leucine rich repeat;
62-147 9.17e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 9.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  62 SHLSTLILTGNPIQSLALGAFSGLSSLqklvavetnlaslenfpighlktlKELNVAHNLIQSFkLPEYFSNLTNLEHLD 141
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNL------------------------KVLDLSNNLLTTL-SPGAFSGLPSLRYLD 55


                  ....*.
gi 1622868247 142 LSSNKI 147
Cdd:pfam13855  56 LSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
539-585 2.21e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.11  E-value: 2.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622868247  539 NDFACTCEHQSFLQWIKDQRQLLVEaERMECATPSDKQGmPVLSLNI 585
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDP-VDLRCASPSSLRG-PLLELLH 45
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 381-539 1.07e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 381 LEKLEHLDFQHSNLKQMSQFSVFLSLRNLiYL---DISH----------THTRVAFNGI-----FDGLLSLKVLKMAGNS 442
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVL-YLydnKITKienlefltnlTHLYLQNNQIekienLENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 443 FQ--ENflpdiFTDLKNLTFLDLSQCQLEQLSPTAFDT------LNKLQVLNMSHNNFFSLDtfPYKCLPSLQVLDYSLN 514
Cdd:cd21340    80 ISvvEG-----LENLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNN 152

                         170       180
                  ....*....|....*....|....*...
gi 1622868247 515 HImtSNNQELQHFPSSLAFL---NLTQN 539
Cdd:cd21340   153 QI--SDLEELLDLLSSWPSLrelDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
188-496 1.31e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 188 LHKLTLRSNFDDLNVMKTCIQGLAGLEVHRLVLGEFRNERNLEEFDKSSLEGLCNLTieefRLTYLDYYLDNIIDLFNCL 267
Cdd:COG4886    57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT----NLESLDLSGNQLTDLPEEL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 268 ANVSSFslvsvsikrvedfsynfrwQHLELVNCKFEQFPT--LELESLKRLTFTANKGGNAFSEV-DLPSLEFLDLSKNG 344
Cdd:COG4886   133 ANLTNL-------------------KELDLSNNQLTDLPEplGNLTNLKSLDLSNNQLTDLPEELgNLTNLKELDLSNNQ 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 345 LS-----FKGCcsqsdfgtTSLKYLDLSFNDVITMSSNFLGLEKLEHLDFQHSNLK-------------------QMSQF 400
Cdd:COG4886   194 ITdlpepLGNL--------TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTdlpelgnltnleeldlsnnQLTDL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 401 SVFLSLRNLIYLDISHTH-TRVAFNGIFDGLLSLKVLKMAGNSFQENFLPDIFTDLKNLTFLDLSQCQLEQLSPTAFDTL 479
Cdd:COG4886   266 PPLANLTNLKTLDLSNNQlTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                         330
                  ....*....|....*..
gi 1622868247 480 NKLQVLNMSHNNFFSLD 496
Cdd:COG4886   346 LLALLTLLLLLNLLSLL 362
LRR_8 pfam13855
Leucine rich repeat;
432-492 1.56e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622868247 432 SLKVLKMAGNSFQeNFLPDIFTDLKNLTFLDLSQCQLEQLSPTAFDTLNKLQVLNMSHNNF 492
Cdd:pfam13855   2 NLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
1-103 4.50e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 44.75  E-value: 4.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247   1 MELKFYKIP--DNI-----PFSTknLDLSFNPLRHLGSYSFLRfpELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNP 73
Cdd:pfam14580  24 LDLRGYKIPiiENLgatldQFDT--IDFSDNEIRKLDGFPLLR--RLKTLLLNNNRICRIGEGLGEALPNLTELILTNNN 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622868247  74 IQSlaLGAFSGLSSLQKLvaveTNLASLEN 103
Cdd:pfam14580 100 LQE--LGDLDPLASLKKL----TFLSLLRN 123
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 17-490 4.53e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 4.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  17 KNLDLSFNPLRHLGSYSFLRFPELQVLDLSRCEIQ-TIEDGAYQSLSHLSTLILTGNPIQ-SLALGAFSGLSSLQklvaV 94
Cdd:PLN00113   72 VSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLD----L 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  95 ETNLASLENF-PIGHLKTLKELNVAHNLIQSfKLPEYFSNLTNLEHLDLSSNkiqniyckdlQVLHQMPLsnlsldlsln 173
Cdd:PLN00113  148 SNNMLSGEIPnDIGSFSSLKVLDLGGNVLVG-KIPNSLTNLTSLEFLTLASN----------QLVGQIPR---------- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 174 pinfiQPGAFKEIRLHKLtlrsNFDDLN-VMKTCIQGLAGLEVHRLVLGefrnerNLEEFDKSSLEGLCNLtieEFRLTY 252
Cdd:PLN00113  207 -----ELGQMKSLKWIYL----GYNNLSgEIPYEIGGLTSLNHLDLVYN------NLTGPIPSSLGNLKNL---QYLFLY 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 253 LDYYLDNIIDLFNCLANVSSFslvsvsikrveDFSYNFRWQHL-ELVnckfEQFPTLELESLKRLTFTANKGGNAFSevd 331
Cdd:PLN00113  269 QNKLSGPIPPSIFSLQKLISL-----------DLSDNSLSGEIpELV----IQLQNLEILHLFSNNFTGKIPVALTS--- 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 332 LPSLEFLDLSKNGLSFKgccSQSDFGT-TSLKYLDLSFNDV----------------ITMSSNFLGLE---------KLE 385
Cdd:PLN00113  331 LPRLQVLQLWSNKFSGE---IPKNLGKhNNLTVLDLSTNNLtgeipeglcssgnlfkLILFSNSLEGEipkslgacrSLR 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 386 HLDFQHSNLK-QMSqfSVFLSLRNLIYLDISHTHTRVAFNGIFDGLLSLKVLKMAGNSFQENfLPDIFTDlKNLTFLDLS 464
Cdd:PLN00113  408 RVRLQDNSFSgELP--SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGG-LPDSFGS-KRLENLDLS 483

                         490       500
                  ....*....|....*....|....*.
gi 1622868247 465 QCQLEQLSPTAFDTLNKLQVLNMSHN 490
Cdd:PLN00113  484 RNQFSGAVPRKLGSLSELMQLKLSEN 509
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 312-509 5.79e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 5.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 312 SLKRLTFTANKGGNAFSEVDLPSLEFLDLSKNGLSFKgccSQSDFGT-TSLKYLDLSFNDVITMSSNFLG-LEKLEHLDF 389
Cdd:PLN00113  119 SLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGE---IPNDIGSfSSLKVLDLGGNVLVGKIPNSLTnLTSLEFLTL 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 390 QH--------SNLKQMSQFS-VFLSLRNL---IYLDI----SHTHTRVAFNGI-------FDGLLSLKVLKMAGNSFQEN 446
Cdd:PLN00113  196 ASnqlvgqipRELGQMKSLKwIYLGYNNLsgeIPYEIggltSLNHLDLVYNNLtgpipssLGNLKNLQYLFLYQNKLSGP 275

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622868247 447 FLPDIFtDLKNLTFLDLSQCQLEQLSPTAFDTLNKLQVLNMSHNNFFSLDTFPYKCLPSLQVL 509
Cdd:PLN00113  276 IPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL 337
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 332-542 1.50e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 332 LPSLEFLDLSKNGLSFKgcCSQSDFGTT-SLKYLDLSFNDVI-TMSSNFLGLekLEHLDFQHSnlkqmsqfsvflSLRNL 409
Cdd:PLN00113   92 LPYIQTINLSNNQLSGP--IPDDIFTTSsSLRYLNLSNNNFTgSIPRGSIPN--LETLDLSNN------------MLSGE 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247 410 IYLDIshthtrvafnGIFDgllSLKVLKMAGNsFQENFLPDIFTDLKNLTFLDLSQCQLEQLSPTAFDTLNKLQVLNMSH 489
Cdd:PLN00113  156 IPNDI----------GSFS---SLKVLDLGGN-VLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGY 221

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622868247 490 NNFFSldTFPYKC--LPSLQVLDYSLNHIMTSNNQELQHFpSSLAFLNLTQNDFA 542
Cdd:PLN00113  222 NNLSG--EIPYEIggLTSLNHLDLVYNNLTGPIPSSLGNL-KNLQYLFLYQNKLS 273
LRR_8 pfam13855
Leucine rich repeat;
407-468 1.62e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622868247 407 RNLIYLDISHTHTRVAFNGIFDGLLSLKVLKMAGNSFQEnFLPDIFTDLKNLTFLDLSQCQL 468
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
111-150 1.91e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622868247 111 TLKELNVAHNLIQSFKlPEYFSNLTNLEHLDLSSNKIQNI 150
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTL 40
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 15-155 2.11e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  15 STKNLDLSFNPLRHLGSY------SFLRFPELQVLDLSRCEIQTIEDGAYQSLSHLSTL---ILTGNPIQSLAL-----G 80
Cdd:cd00116    52 SLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLrllakG 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  81 AFSGLSSLQKLVAVETNLASLENFPIG----HLKTLKELNVAHNLIQSF---KLPEYFSNLTNLEHLDLSSNKIQNIYCK 153
Cdd:cd00116   132 LKDLPPALEKLVLGRNRLEGASCEALAkalrANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTDEGAS 211


                  ..
gi 1622868247 154 DL 155
Cdd:cd00116   212 AL 213
LRR_8 pfam13855
Leucine rich repeat;
481-541 4.68e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622868247 481 KLQVLNMSHNNFFSLDTFPYKCLPSLQVLDYSLNHIMTSNNQELQHFPsSLAFLNLTQNDF 541
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
359-418 1.72e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622868247 359 TSLKYLDLSFNDVITMS-SNFLGLEKLEHLDFQHSNLKQMSQfSVFLSLRNLIYLDISHTH 418
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-149 1.97e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  19 LDLSFNPLRHLGS---YSFLRFPELQVLDLSRCEI-----QTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSG-LSSLQ 89
Cdd:cd00116    86 LDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKaLRANR 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622868247  90 KLVAVETNLASLENFPIGHL-------KTLKELNVAHNLIQS---FKLPEYFSNLTNLEHLDLSSNKIQN 149
Cdd:cd00116   166 DLKELNLANNGIGDAGIRALaeglkanCNLEVLDLNNNGLTDegaSALAETLASLKSLEVLNLGDNNLTD 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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