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Conserved domains on  [gi|1622865855|ref|XP_014970948|]
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protocadherin Fat 3 isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3241-3337 2.71e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.59  E-value: 2.71e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3241 YLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPA 3320
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1622865855 3321 LSAVATVNINLTDVNDN 3337
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1049-1144 1.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.37e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETTGSYWLTVYATDRGVVPL 1128
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1622865855 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3345-3442 9.21e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 9.21e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3345 VYSTVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIP 3424
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1622865855 3425 PMSSTATLNIDISDVNDN 3442
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1152-1250 1.75e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1152 IYYPVVMENSPKDISVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGP 1231
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1622865855 1232 SPKQSTIWVVVQVLDENDN 1250
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2818-2920 6.11e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.87  E-value: 6.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2818 SYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKvmeaFNIDSNTGWISTLKDLDHETDPTFTFSVVASD 2897
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1622865855 2898 LGEaFSLSSTALVSVRVTDINDN 2920
Cdd:cd11304     77 GGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-574 1.40e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.40e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  477 YDANVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEiYRFIVRASDWGSP 555
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1622865855  556 yRHESEVNVTIRIGNVNDN 574
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3865-3994 1.57e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 1.57e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3865 LRTLQSNGIIMYTRA--NPCIILKIVDGKLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRR 3942
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622865855 3943 APLYFQTLSTESSIYFGALVQADNIRSLtdtrvtQVLSGFQGCLDSVILNNN 3994
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLLLPAL------PVRAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 733-827 1.13e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 1.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1622865855  813 SWRLLTINVEDANDN 827
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1773-1879 2.10e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 2.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1773 QYSGSLSEAAPINSIVrsldnspLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVH 1852
Cdd:cd11304      1 SYEVSVPENAPPGTVV-------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*..
gi 1622865855 1853 VRDSGSPQLTaeSPVEVNIEVTDVNDN 1879
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2291-2390 3.87e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.87e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2291 TYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSTDSG 2370
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1622865855 2371 FPSLSSEVLVHIYISDVNDN 2390
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 835-931 4.89e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 4.89e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  835 SYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAes 912
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1622865855  913 GQQLFSVVTLKVFLDDVND 931
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3034-3127 1.00e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 1.00e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSEFF-LDPESGELKTLALLDRERVPVYSLMAKATDGGG-- 3110
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1622865855 3111 RFCQANIHLILEDVNDN 3127
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 7.21e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 7.21e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  162 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 239
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1622865855  240 lyGNNGVSSTAKLYVHIERINEH 262
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1465-1562 9.75e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 9.75e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1465 YDVTISEDVLPDTEILQIEATDRDEKH--KLSYTVHSSIDSismRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1542
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1622865855 1543 FPYRRNLARVIVNVEDANDH 1562
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1676-1765 1.76e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1676 YQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGDINGIFTINPYSGVITTRKVLDYERTSSYQLIIQATNMAG-- 1748
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1622865855 1749 MASNATVNIQIVDENDN 1765
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1571-1662 1.98e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.98e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1571 YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNTFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPP 1650
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|..
gi 1622865855 1651 MSATAIVRISVT 1662
Cdd:cd11304     82 LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1018 1.10e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2500-2596 1.50e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 1.50e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2500 TYVAEVRENAAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSN-GQVITTERLDRENPLEgdVSIFVRALDGG 2578
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1622865855 2579 G--RTTFCTVRVIVVDENDN 2596
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2928-3025 5.62e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 5.62e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2928 VYRGNVKESDPPGEVVAVLSTWDRDtSDINRQVSYHITGGNPRGRFALGlvQSEWKVYVKRPLDREEQDIYFLNITATDG 3007
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSID--PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1622865855 3008 ---LFVTQAMVEVSVSDVNDN 3025
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3135-3232 1.26e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 1.26e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3135 HYNACIYENTATKALLTRVQAVDPDVGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSpG 3213
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                           90
                   ....*....|....*....
gi 1622865855 3214 QSLSSLTTVTITVLDINDN 3232
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2088-2179 1.86e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 1.86e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2088 PYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNiEYGVTILAKDGGK 2165
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1622865855 2166 PSLSTSVELPITIV 2179
Cdd:cd11304     80 PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1258-1348 1.16e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 1.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1258 VYQIKLPERDrkKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 1334
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1622865855 1335 GRPQKSSTARLHIE 1348
Cdd:cd11304     78 GGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2604-2699 7.01e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 7.01e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2604 EYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEasvSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDG 2683
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1622865855 2684 GIPVKHSLIPVYIHVL 2699
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2398-2490 1.16e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.16e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2398 IYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG--- 2474
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 1622865855 2475 LFTSTAQVHIRVLGAN 2490
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3451-3542 1.36e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 1.36e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3451 YTAVIQENKPVGTSILQLVVTDRDSFHNGpPFSFSILSGNEEEEFVLDSH-GILRSAVVFQHTESLEYVLCVQAKDSGKP 3529
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1622865855 3530 QQVSHTYIRVRVI 3542
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2191-2283 1.57e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 1.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2191 YTASVNEDIRMNTPILSINATSPEGQGIIYII---IDGDPFKQFNVDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGA 2267
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTysiVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1622865855 2268 R-AEVTVDLLVNDVNDN 2283
Cdd:cd11304     82 LsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1367-1456 4.45e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 4.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1367 YNFTVMESDRVTEIVGVVSVQ----PANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN-- 1440
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1622865855 1441 -VAVTQVFIKVLDNNDN 1456
Cdd:cd11304     82 lSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-468 1.58e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 1.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  380 VYDVSVSEFSPPGVVVAIVKL----SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTAQPLNTVKKEVYKLEVTNKEGDL- 454
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1622865855  455 ----KTQVTISIEDANDH 468
Cdd:cd11304     81 plssTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1898-1977 1.80e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.88  E-value: 1.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDG---KFYSTSMVTIM 1971
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKplDREEQSSYTLTVTATDGggpPLSSTATVTIT 91


                   ....*.
gi 1622865855 1972 VKEAMD 1977
Cdd:cd11304     92 VLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1987-2080 5.05e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 5.05e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1987 YSTSISENNTNITKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASRELDY 2062
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1622865855 2063 LRVARVVVRVNIEDINDN 2080
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2712-2810 3.09e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 3.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2712 QYSFTIAEDTAIGSTVDTLR-----ILPSQNVRFSTVNGerpenNKGGVFVIEQETGTIKLDKRLDHETSPAFHFKVAAT 2786
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....*.
gi 1622865855 2787 iplDKVDIVFA--VDVDIKVLDLNDN 2810
Cdd:cd11304     76 ---DGGGPPLSstATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 592-672 1.24e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  592 PVGGHITAVSAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSgiKNGNFALRITATDGEN--LADPMSI 667
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1622865855  668 NISVL 672
Cdd:cd11304     89 TITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3561-3638 1.74e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3561 MEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQ-KSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDG---RFQVPI 3631
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreeQSSYTLTVTATDGggpPLSSTA 86


                   ....*..
gi 1622865855 3632 DVVVHVE 3638
Cdd:cd11304     87 TVTITVL 93
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4023-4058 2.01e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 2.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1622865855 4023 DACE-RSPCQHGGSCTGLPsGGYQCTCLSQFTGRNCE 4058
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-153 2.87e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.24  E-value: 2.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   47 IYNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNR 119
Cdd:cd11304      1 SYEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDR 62

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1622865855  120 EIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMND 153
Cdd:cd11304     63 EEQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4057-4096 4.19e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 4.19e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622865855 4057 CESeitacfPNPCRNGGSCDPIGNTFICNCKAGLTGVTCE 4096
Cdd:cd00054      5 CAS------GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4110-4133 6.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 6.92e-06
                           10        20
                   ....*....|....*....|....
gi 1622865855 4110 GGSCVNVFGSFLCNCTPGYVGQYC 4133
Cdd:cd00054     14 GGTCVNTVGSYRCSCPPGYTGRNC 37
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 283-357 4.40e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 4.40e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865855  283 AVVTVDDLDDGANGEIeSVSIVAGDPLDQFFLAKEGKWlneykIKERKQIDWESFPYgYNLTLQAKDKGSPQKFS 357
Cdd:pfam00028   16 LTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDTGD-----ISTTKPLDRESIGE-YELTVEATDSGGPPLSS 83
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3241-3337 2.71e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.59  E-value: 2.71e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3241 YLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPA 3320
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1622865855 3321 LSAVATVNINLTDVNDN 3337
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1049-1144 1.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.37e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETTGSYWLTVYATDRGVVPL 1128
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1622865855 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3345-3442 9.21e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 9.21e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3345 VYSTVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIP 3424
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1622865855 3425 PMSSTATLNIDISDVNDN 3442
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1152-1250 1.75e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1152 IYYPVVMENSPKDISVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGP 1231
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1622865855 1232 SPKQSTIWVVVQVLDENDN 1250
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2818-2920 6.11e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.87  E-value: 6.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2818 SYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKvmeaFNIDSNTGWISTLKDLDHETDPTFTFSVVASD 2897
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1622865855 2898 LGEaFSLSSTALVSVRVTDINDN 2920
Cdd:cd11304     77 GGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-574 1.40e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.40e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  477 YDANVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEiYRFIVRASDWGSP 555
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1622865855  556 yRHESEVNVTIRIGNVNDN 574
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3865-3994 1.57e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 1.57e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3865 LRTLQSNGIIMYTRA--NPCIILKIVDGKLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRR 3942
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622865855 3943 APLYFQTLSTESSIYFGALVQADNIRSLtdtrvtQVLSGFQGCLDSVILNNN 3994
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLLLPAL------PVRAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 733-827 1.13e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 1.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1622865855  813 SWRLLTINVEDANDN 827
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1773-1879 2.10e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 2.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1773 QYSGSLSEAAPINSIVrsldnspLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVH 1852
Cdd:cd11304      1 SYEVSVPENAPPGTVV-------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*..
gi 1622865855 1853 VRDSGSPQLTaeSPVEVNIEVTDVNDN 1879
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2291-2390 3.87e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.87e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2291 TYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSTDSG 2370
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1622865855 2371 FPSLSSEVLVHIYISDVNDN 2390
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 835-931 4.89e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 4.89e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  835 SYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAes 912
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1622865855  913 GQQLFSVVTLKVFLDDVND 931
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1066-1146 4.16e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 104.35  E-value: 4.16e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  1066 TARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETTGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1145
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1622865855  1146 P 1146
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3034-3127 1.00e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 1.00e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSEFF-LDPESGELKTLALLDRERVPVYSLMAKATDGGG-- 3110
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1622865855 3111 RFCQANIHLILEDVNDN 3127
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3260-3339 1.64e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.81  E-value: 1.64e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3260 ATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPP 3339
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3837-3992 2.90e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.81  E-value: 2.90e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3837 SLSFAGNSYIKYRLSENSKEEdFKLALRLRTLQSNGIIMYT---RANPCIILKIVDGKLWFQLDCGSGPGILGiSGRAVN 3913
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGRLVLRYDLGSGSLVLS-SKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855 3914 DGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVqadnirSLTDTRVTQVLSGFQGCLDSVILN 3992
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLP------EDLKSPGLPVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 7.21e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 7.21e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  162 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 239
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1622865855  240 lyGNNGVSSTAKLYVHIERINEH 262
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3241-3332 9.22e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.84  E-value: 9.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3241 YLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPA 3320
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1622865855 3321 LSAVATVNINLT 3332
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1465-1562 9.75e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 9.75e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1465 YDVTISEDVLPDTEILQIEATDRDEKH--KLSYTVHSSIDSismRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1542
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1622865855 1543 FPYRRNLARVIVNVEDANDH 1562
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1676-1765 1.76e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1676 YQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGDINGIFTINPYSGVITTRKVLDYERTSSYQLIIQATNMAG-- 1748
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1622865855 1749 MASNATVNIQIVDENDN 1765
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1571-1662 1.98e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.98e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1571 YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNTFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPP 1650
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|..
gi 1622865855 1651 MSATAIVRISVT 1662
Cdd:cd11304     82 LSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3365-3444 3.28e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.96  E-value: 3.28e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3365 AEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPPMSSTATLNIDISDVNDNSP 3444
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1018 1.10e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2500-2596 1.50e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 1.50e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2500 TYVAEVRENAAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSN-GQVITTERLDRENPLEgdVSIFVRALDGG 2578
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1622865855 2579 G--RTTFCTVRVIVVDENDN 2596
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1171-1252 2.60e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 2.60e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRkLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDN 1250
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1622865855  1251 KP 1252
Cdd:smart00112   80 AP 81
LamG smart00282
Laminin G domain;
3860-3994 3.64e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 97.80  E-value: 3.64e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3860 KLALRLRTLQSNGIIMYTRANP---CIILKIVDGKLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDS 3936
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggdYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865855  3937 YVERRRAPLYFQTLSTESSIYFGALVQADNIRSLTDTrvtqvlSGFQGCLDSVILNNN 3994
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT------PGFRGCIRNLKVNGK 132
Cadherin pfam00028
Cadherin domain;
1049-1139 6.65e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 6.65e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETTGSYWLTVYATDRGVVPL 1128
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1622865855 1129 YSTIEVYIEVE 1139
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3346-3436 9.07e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 9.07e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3346 YSTVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPP 3425
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1622865855 3426 MSSTATLNIDI 3436
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2837-2922 3.05e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.57  E-value: 3.05e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  2837 RAIDMDWGANGQVTYSLHSDSQPEKvmeaFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAfSLSSTALVSVRVTD 2916
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLD 75


                    ....*.
gi 1622865855  2917 INDNAP 2922
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1799-1881 3.74e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 3.74e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  1799 RATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTaeSPVEVNIEVTDVND 1878
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS--STATVTITVLDVND 78


                    ...
gi 1622865855  1879 NPP 1881
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2928-3025 5.62e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 5.62e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2928 VYRGNVKESDPPGEVVAVLSTWDRDtSDINRQVSYHITGGNPRGRFALGlvQSEWKVYVKRPLDREEQDIYFLNITATDG 3007
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSID--PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1622865855 3008 ---LFVTQAMVEVSVSDVNDN 3025
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 749-829 9.53e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 9.53e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   749 KAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNS 828
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1622865855   829 P 829
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3135-3232 1.26e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 1.26e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3135 HYNACIYENTATKALLTRVQAVDPDVGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSpG 3213
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                           90
                   ....*....|....*....
gi 1622865855 3214 QSLSSLTTVTITVLDINDN 3232
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1157-1245 1.17e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 1.17e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1157 VMENSPKDISVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRkLDREQQAEHFLEVTVTDGGPSPKQS 1236
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1622865855 1237 TIWVVVQVL 1245
Cdd:pfam00028   84 TATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2088-2179 1.86e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 1.86e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2088 PYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNiEYGVTILAKDGGK 2165
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1622865855 2166 PSLSTSVELPITIV 2179
Cdd:cd11304     80 PPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2312-2392 2.25e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 2.25e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  2312 IDADSENNKMVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSTDSGFPSLSSEVLVHIYISDVNDNP 2391
Cdd:smart00112    3 TDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1622865855  2392 P 2392
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-576 4.00e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 4.00e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   495 SASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEiYRFIVRASDWGSPyRHESEVNVTIRIGNVND 573
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1622865855   574 NSP 576
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
477-568 9.60e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.59  E-value: 9.60e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  477 YDANVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FAINQFTGVISTTEELDFEsSPEIYRFIVRASDWGSP 555
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1622865855  556 YRhESEVNVTIRI 568
Cdd:pfam00028   80 PL-SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3052-3129 1.10e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 1.10e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3052 SAKDADIGSNGDIRYSL-YGSGNSEFFLDPESGELKTLALLDRERVPVYSLMAKATDGGG--RFCQANIHLILEDVNDNP 3128
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNA 80


                    .
gi 1622865855  3129 P 3129
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1258-1348 1.16e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 1.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1258 VYQIKLPERDrkKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 1334
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1622865855 1335 GRPQKSSTARLHIE 1348
Cdd:cd11304     78 GGPPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 855-934 3.76e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 3.76e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   855 ARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAesGQQLFSVVTLKVFLDDVNDC 932
Cdd:smart00112    2 ATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1622865855   933 SP 934
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2604-2699 7.01e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 7.01e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2604 EYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEasvSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDG 2683
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1622865855 2684 GIPVKHSLIPVYIHVL 2699
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2398-2490 1.16e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.16e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2398 IYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG--- 2474
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 1622865855 2475 LFTSTAQVHIRVLGAN 2490
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3451-3542 1.36e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 1.36e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3451 YTAVIQENKPVGTSILQLVVTDRDSFHNGpPFSFSILSGNEEEEFVLDSH-GILRSAVVFQHTESLEYVLCVQAKDSGKP 3529
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1622865855 3530 QQVSHTYIRVRVI 3542
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
941-1018 2.04e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 2.04e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855  941 YSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR-FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
1571-1662 2.40e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 2.40e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1571 YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNTFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPP 1650
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1622865855 1651 MSATAIVRISVT 1662
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1699-1767 2.53e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 2.53e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622865855  1699 STLIYEVKDGDINGIFTINPYSGVITTRKVLDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAP 1767
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3154-3234 3.08e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 3.08e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3154 QAVDPDVGINRKVVYSLAD-SAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSpGQSLSSLTTVTITVLDINDN 3232
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1622865855  3233 PP 3234
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
2501-2590 1.09e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.09e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2501 YVAEVRENAAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPleGDVSIFVRALDGGG 2579
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|.
gi 1622865855 2580 RTTFCTVRVIV 2590
Cdd:pfam00028   79 PPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
836-924 1.25e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  836 YSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDT--QQFAINSSTGIVYVADQLDRESKANYSLKIEARDkaESG 913
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD--SGG 78

                           90
                   ....*....|.
gi 1622865855  914 QQLFSVVTLKV 924
Cdd:pfam00028   79 PPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
1774-1872 1.67e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 1.67e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1774 YSGSLSEAAPINSIVrsldnspLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHV 1853
Cdd:pfam00028    1 YSASVPENAPVGTEV-------LTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 1622865855 1854 RDSGSPQLTAESPVEVNIE 1872
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1676-1759 3.85e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 3.85e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1676 YQAEVNENVDIGTSVILISAIS-----QSTLIYEVKDGDINGIFTINPYSGVITTRKVLDYERTSSYQLIIQATNMA--G 1748
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|.
gi 1622865855 1749 MASNATVNIQI 1759
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2819-2915 1.10e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.10e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2819 YDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKvmeaFNIDSNTGWISTLKDLDHETDPTFTFSVVASDL 2898
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN----FRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*..
gi 1622865855 2899 GEAfSLSSTALVSVRVT 2915
Cdd:pfam00028   77 GGP-PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2191-2283 1.57e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 1.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2191 YTASVNEDIRMNTPILSINATSPEGQGIIYII---IDGDPFKQFNVDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGA 2267
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTysiVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1622865855 2268 R-AEVTVDLLVNDVNDN 2283
Cdd:cd11304     82 LsSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2292-2384 7.14e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 7.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2292 YNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSTDSGF 2371
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1622865855 2372 PSLSSEVLVHIYI 2384
Cdd:pfam00028   79 PPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
733-822 8.51e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 8.51e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1622865855  813 SWRLLTINVE 822
Cdd:pfam00028   83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1465-1557 1.17e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 1.17e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1465 YDVTISEDVLPDTEILQIEATDRDEK--HKLSYTVhssIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1542
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1622865855 1543 FPYRRNLARVIVNVE 1557
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2519-2598 1.28e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.69  E-value: 1.28e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  2519 RATDGDPGTYGQISYAIINDFAKDRFLIDSN-GQVITTERLDRENplEGDVSIFVRALDGGG--RTTFCTVRVIVVDEND 2595
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREE--QPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                    ...
gi 1622865855  2596 NAP 2598
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1484-1564 2.76e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 2.76e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  1484 ATDRDE--KHKLSYTVHSSIDSismRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAND 1561
Cdd:smart00112    2 ATDADSgeNGKVTYSILSGNDD---GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1622865855  1562 HSP 1564
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
1259-1348 2.77e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 2.77e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1259 YQIKLPERDRkkRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDNG 1335
Cdd:pfam00028    1 YSASVPENAP--VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdreSIGEY-ELTVEATDSG 77

                           90
                   ....*....|...
gi 1622865855 1336 RPQKSSTARLHIE 1348
Cdd:pfam00028   78 GPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
3136-3227 2.93e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 2.93e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3136 YNACIYENTATKALLTRVQAVDPDVGINRKVVYS-LADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSpGQ 3214
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                           90
                   ....*....|...
gi 1622865855 3215 SLSSLTTVTITVL 3227
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1367-1456 4.45e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 4.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1367 YNFTVMESDRVTEIVGVVSVQ----PANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN-- 1440
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1622865855 1441 -VAVTQVFIKVLDNNDN 1456
Cdd:cd11304     82 lSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-264 6.77e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 6.77e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   181 TATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKlygnnGVSSTAKLYVHIER 258
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-----PLSSTATVTITVLD 75


                    ....*.
gi 1622865855   259 INEHAP 264
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1280-1348 8.39e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 8.39e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622865855  1280 AFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYDiLTIKAVDNGRPQKSSTARLHIE 1348
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2950-3027 1.10e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.10e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  2950 DRDtSDINRQVSYHITGGNPRGRFALGLVQSEwkVYVKRPLDREEQDIYFLNITATDG---LFVTQAMVEVSVSDVNDNS 3026
Cdd:smart00112    4 DAD-SGENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 1622865855  3027 P 3027
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1589-1667 1.11e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.11e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  1589 TALDKDKGENAELIYTIEAGNTGNTFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVT-MSDNS 1667
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLdVNDNA 80
Cadherin pfam00028
Cadherin domain;
163-257 1.43e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 1.43e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  163 YSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmkl 240
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*..
gi 1622865855  241 yGNNGVSSTAKLYVHIE 257
Cdd:pfam00028   77 -GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-468 1.58e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 1.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  380 VYDVSVSEFSPPGVVVAIVKL----SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTAQPLNTVKKEVYKLEVTNKEGDL- 454
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1622865855  455 ----KTQVTISIEDANDH 468
Cdd:cd11304     81 plssTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3034-3122 2.14e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 2.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSEFF-LDPESGELKTLALLDRERVPVYSLMAKATDGG--G 3110
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFrIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 1622865855 3111 RFCQANIHLILE 3122
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 961-1018 2.89e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 2.89e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855   961 HDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:smart00112    3 TDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP 61
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1898-1977 1.80e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.88  E-value: 1.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDG---KFYSTSMVTIM 1971
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKplDREEQSSYTLTVTATDGggpPLSSTATVTIT 91


                   ....*.
gi 1622865855 1972 VKEAMD 1977
Cdd:cd11304     92 VLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1987-2080 5.05e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 5.05e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1987 YSTSISENNTNITKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASRELDY 2062
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1622865855 2063 LRVARVVVRVNIEDINDN 2080
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2089-2178 5.12e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 5.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2089 YYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNiEYGVTILAKDGGKP 2166
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIG-EYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1622865855 2167 SLSTSVELPITI 2178
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2224-2285 8.37e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 8.37e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622865855  2224 DGDPFKQFNVDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGAR-AEVTVDLLVNDVNDNPP 2285
Cdd:smart00112   19 SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLsSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2712-2810 3.09e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 3.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2712 QYSFTIAEDTAIGSTVDTLR-----ILPSQNVRFSTVNGerpenNKGGVFVIEQETGTIKLDKRLDHETSPAFHFKVAAT 2786
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....*.
gi 1622865855 2787 iplDKVDIVFA--VDVDIKVLDLNDN 2810
Cdd:cd11304     76 ---DGGGPPLSstATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2191-2276 9.61e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 9.61e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2191 YTASVNEDIRMNTPILSINAT---SPEGQGIIYIIIDGDPFKQFNVDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGA 2267
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1622865855 2268 R---AEVTVDLL 2276
Cdd:pfam00028   81 LsstATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2605-2699 1.16e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2605 YRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGG 2684
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1622865855 2685 IPVKHSLIPVYIHVL 2699
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1387-1458 2.22e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.37  E-value: 2.22e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865855  1387 QPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN---VAVTQVFIKVLDNNDNGP 1458
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGpplSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 592-672 1.24e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  592 PVGGHITAVSAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSgiKNGNFALRITATDGEN--LADPMSI 667
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1622865855  668 NISVL 672
Cdd:cd11304     89 TITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2107-2179 3.01e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.29  E-value: 3.01e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865855  2107 TAIDKDKGPNGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNiEYGVTILAKDGGKPSLSTSVELPITIV 2179
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQP-EYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 401-470 4.11e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 4.11e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865855   401 SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTAQPLNTVKKEVYKLEVTNKEGDLK-----TQVTISIEDANDHTP 470
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplsstATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2623-2699 5.56e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 5.56e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865855  2623 QAIDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVL 2699
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
3451-3542 7.22e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 7.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3451 YTAVIQENKPVGTSILQLVVTDRDSFHNGPPFsFSILSGNEEEEFVLDSH-GILRSAVVFQHTESLEYVLCVQAKDSGKP 3529
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1622865855 3530 QQVSHTYIRVRVI 3542
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3469-3549 8.54e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.13  E-value: 8.54e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3469 VVTDRDSFHNGPpFSFSILSGNEEEEFVLDSH-GILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTH 3547
Cdd:smart00112    1 SATDADSGENGK-VTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1622865855  3548 KP 3549
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2417-2490 1.33e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 1.33e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855  2417 QASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNH--RKQRmePLYSLNVSVSDG---LFTSTAQVHIRVLGAN 2490
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPldREEQ--PEYTLTVEATDGggpPLSSTATVTITVLDVN 77
Cadherin pfam00028
Cadherin domain;
2399-2487 2.51e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 2.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2399 YESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNH--RKQRmePLYSLNVSVSDGLF 2476
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPldRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1622865855 2477 ---TSTAQVHIRVL 2487
Cdd:pfam00028   79 pplSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2929-3007 2.59e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2929 YRGNVKESDPPGEVVAVLSTWDRDTSDiNRQVSYHITGGNPRGRFAL----GLVqsewkvYVKRPLDREEQDIYFLNITA 3004
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRIdpdtGDI------STTKPLDRESIGEYELTVEA 73


                   ...
gi 1622865855 3005 TDG 3007
Cdd:pfam00028   74 TDS 76
Cadherin pfam00028
Cadherin domain;
1987-2057 7.57e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 7.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865855 1987 YSTSISENNTNITKVAIVNAV----GnrLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEAS 2057
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlG--PNGRIFYSILggGPGGNFRIDPDTGDISTTK-PLDRESIGEYELTVEAT 74
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3561-3638 1.74e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3561 MEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQ-KSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDG---RFQVPI 3631
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreeQSSYTLTVTATDGggpPLSSTA 86


                   ....*..
gi 1622865855 3632 DVVVHVE 3638
Cdd:cd11304     87 TVTITVL 93
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4023-4058 2.01e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 2.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1622865855 4023 DACE-RSPCQHGGSCTGLPsGGYQCTCLSQFTGRNCE 4058
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2012-2082 2.19e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 2.19e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622865855  2012 NEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASRELDYLRVARVVVRVNIEDINDNSP 2082
Cdd:smart00112   10 NGKVTYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-153 2.87e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.24  E-value: 2.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   47 IYNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNR 119
Cdd:cd11304      1 SYEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDR 62

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1622865855  120 EIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMND 153
Cdd:cd11304     63 EEQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
1367-1451 5.43e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 5.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1367 YNFTVMESDRVTEIVGVVSVQ----PANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN-- 1440
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpp 80

                           90
                   ....*....|..
gi 1622865855 1441 -VAVTQVFIKVL 1451
Cdd:pfam00028   81 lSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
592-672 1.72e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  592 PVGGHITAVSAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSLtnSGIKNGNFALRITATD--GENLADPMSI 667
Cdd:pfam00028   10 PVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDsgGPPLSSTATV 87


                   ....*
gi 1622865855  668 NISVL 672
Cdd:pfam00028   88 TITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2734-2812 2.65e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 2.65e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  2734 PSQNVRFSTVNGerpenNKGGVFVIEQETGTIKLDKRLDHETSPAFHFKVAATiplDKVDIVFA--VDVDIKVLDLNDNK 2811
Cdd:smart00112    9 ENGKVTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT---DGGGPPLSstATVTITVLDVNDNA 80


                    .
gi 1622865855  2812 P 2812
Cdd:smart00112   81 P 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4057-4096 4.19e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 4.19e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622865855 4057 CESeitacfPNPCRNGGSCDPIGNTFICNCKAGLTGVTCE 4096
Cdd:cd00054      5 CAS------GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4064-4092 7.17e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 48.15  E-value: 7.17e-07
                           10        20
                   ....*....|....*....|....*....
gi 1622865855 4064 CFPNPCRNGGSCDPIGNTFICNCKAGLTG 4092
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
4023-4058 2.34e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 2.34e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1622865855  4023 DACE-RSPCQHGGSCTGLPsGGYQCTCLSQFT-GRNCE 4058
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
2713-2786 3.64e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 3.64e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855 2713 YSFTIAEDTAIGSTVDTLRIL-----PSQNVRFSTVNGERpennkGGVFVIEQETGTIKLDKRLDHETSPAFHFKVAAT 2786
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlgPNGRIFYSILGGGP-----GGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1906-1977 4.60e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 4.60e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855  1906 SATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTIkNNNL---SKDHYMLIVKVSDG---KFYSTSMVTIMVKEAMD 1977
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITT-TKPLdreEQPEYTLTVEATDGggpPLSSTATVTITVLDVND 78
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 76-156 4.97e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 4.97e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855    76 SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDM 151
Cdd:smart00112   10 NGKVTYSILSGNDDGLF-------------SIDPETGEittTKPLDREEQPEYTLTVEATDGGGPpLSSTATVTITVLDV 76


                    ....*
gi 1622865855   152 NDLRP 156
Cdd:smart00112   77 NDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4110-4133 6.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 6.92e-06
                           10        20
                   ....*....|....*....|....
gi 1622865855 4110 GGSCVNVFGSFLCNCTPGYVGQYC 4133
Cdd:cd00054     14 GGTCVNTVGSYRCSCPPGYTGRNC 37
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 601-672 2.22e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.42  E-value: 2.22e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865855   601 SAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSgiKNGNFALRITATDGEN--LADPMSINISVL 672
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDGGGppLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
1898-1972 1.05e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.83  E-value: 1.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGSLDH-FLIDSNSGVLTIKnNNL---SKDHYMLIVKVSDGKFY---STSMVTI 1970
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTT-KPLdreSIGEYELTVEATDSGGPplsSTATVTI 89


                   ..
gi 1622865855 1971 MV 1972
Cdd:pfam00028   90 TV 91
EGF_CA smart00179
Calcium-binding EGF-like domain;
4057-4096 1.16e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 1.16e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1622865855  4057 CESeitacfPNPCRNGGSCDPIGNTFICNCKAGLT-GVTCE 4096
Cdd:smart00179    5 CAS------GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
381-463 2.72e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.67  E-value: 2.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  381 YDVSVSEFSPPGVVVAIVKL----SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTAQPLNTVKKEVYKLEVTNKEGDLK- 455
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPp 80

                           90
                   ....*....|..
gi 1622865855  456 ----TQVTISIE 463
Cdd:pfam00028   81 lsstATVTITVL 92
Cadherin pfam00028
Cadherin domain;
283-357 4.40e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 4.40e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865855  283 AVVTVDDLDDGANGEIeSVSIVAGDPLDQFFLAKEGKWlneykIKERKQIDWESFPYgYNLTLQAKDKGSPQKFS 357
Cdd:pfam00028   16 LTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDTGD-----ISTTKPLDRESIGE-YELTVEATDSGGPPLSS 83
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4025-4056 5.32e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 5.32e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622865855 4025 CERSPCQHGGSCTGLPsGGYQCTCLSQFTGRN 4056
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 286-364 8.00e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 8.00e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855   286 TVDDLDDGANGEIeSVSIVAGDPLDQFFLAKEGKWlneykIKERKQIDWESFPYgYNLTLQAKDKGSPQKfSALKAVHI 364
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPL-SSTATVTI 71
EGF_CA smart00179
Calcium-binding EGF-like domain;
4110-4133 8.99e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 8.99e-04
                            10        20
                    ....*....|....*....|....*
gi 1622865855  4110 GGSCVNVFGSFLCNCTPGYV-GQYC 4133
Cdd:smart00179   14 GGTCVNTVGSYRCECPPGYTdGRNC 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 4110-4128 7.88e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 7.88e-03
                           10
                   ....*....|....*....
gi 1622865855 4110 GGSCVNVFGSFLCNCTPGY 4128
Cdd:pfam12661    4 GGTCVDGVNGYKCQCPPGY 22
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3241-3337 2.71e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.59  E-value: 2.71e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3241 YLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPA 3320
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1622865855 3321 LSAVATVNINLTDVNDN 3337
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1049-1144 1.37e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.37e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETTGSYWLTVYATDRGVVPL 1128
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1622865855 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3345-3442 9.21e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.27  E-value: 9.21e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3345 VYSTVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIP 3424
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1622865855 3425 PMSSTATLNIDISDVNDN 3442
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1152-1250 1.75e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1152 IYYPVVMENSPKDISVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGP 1231
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1622865855 1232 SPKQSTIWVVVQVLDENDN 1250
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2818-2920 6.11e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.87  E-value: 6.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2818 SYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKvmeaFNIDSNTGWISTLKDLDHETDPTFTFSVVASD 2897
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL----FSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1622865855 2898 LGEaFSLSSTALVSVRVTDINDN 2920
Cdd:cd11304     77 GGG-PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-574 1.40e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.40e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  477 YDANVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEiYRFIVRASDWGSP 555
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1622865855  556 yRHESEVNVTIRIGNVNDN 574
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3865-3994 1.57e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 1.57e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3865 LRTLQSNGIIMYTRA--NPCIILKIVDGKLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRR 3942
Cdd:pfam02210    1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622865855 3943 APLYFQTLSTESSIYFGALVQADNIRSLtdtrvtQVLSGFQGCLDSVILNNN 3994
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLLLPAL------PVRAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 733-827 1.13e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 1.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1622865855  813 SWRLLTINVEDANDN 827
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1773-1879 2.10e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.94  E-value: 2.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1773 QYSGSLSEAAPINSIVrsldnspLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVH 1852
Cdd:cd11304      1 SYEVSVPENAPPGTVV-------LTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*..
gi 1622865855 1853 VRDSGSPQLTaeSPVEVNIEVTDVNDN 1879
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2291-2390 3.87e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.87e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2291 TYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSTDSG 2370
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1622865855 2371 FPSLSSEVLVHIYISDVNDN 2390
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 835-931 4.89e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 4.89e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  835 SYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAes 912
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1622865855  913 GQQLFSVVTLKVFLDDVND 931
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1066-1146 4.16e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 104.35  E-value: 4.16e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  1066 TARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETTGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1145
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1622865855  1146 P 1146
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3034-3127 1.00e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.93  E-value: 1.00e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSEFF-LDPESGELKTLALLDRERVPVYSLMAKATDGGG-- 3110
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFsIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1622865855 3111 RFCQANIHLILEDVNDN 3127
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3260-3339 1.64e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.81  E-value: 1.64e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3260 ATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPP 3339
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3837-3992 2.90e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.81  E-value: 2.90e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3837 SLSFAGNSYIKYRLSENSKEEdFKLALRLRTLQSNGIIMYT---RANPCIILKIVDGKLWFQLDCGSGPGILGiSGRAVN 3913
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGRLVLRYDLGSGSLVLS-SKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855 3914 DGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVqadnirSLTDTRVTQVLSGFQGCLDSVILN 3992
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLP------EDLKSPGLPVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 7.21e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 7.21e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  162 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 239
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1622865855  240 lyGNNGVSSTAKLYVHIERINEH 262
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3241-3332 9.22e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.84  E-value: 9.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3241 YLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPA 3320
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1622865855 3321 LSAVATVNINLT 3332
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1465-1562 9.75e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 9.75e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1465 YDVTISEDVLPDTEILQIEATDRDEKH--KLSYTVHSSIDSismRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1542
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1622865855 1543 FPYRRNLARVIVNVEDANDH 1562
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1676-1765 1.76e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1676 YQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGDINGIFTINPYSGVITTRKVLDYERTSSYQLIIQATNMAG-- 1748
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1622865855 1749 MASNATVNIQIVDENDN 1765
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1571-1662 1.98e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.98e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1571 YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNTFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPP 1650
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|..
gi 1622865855 1651 MSATAIVRISVT 1662
Cdd:cd11304     82 LSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3365-3444 3.28e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.96  E-value: 3.28e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3365 AEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPPMSSTATLNIDISDVNDNSP 3444
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1018 1.10e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2500-2596 1.50e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.77  E-value: 1.50e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2500 TYVAEVRENAAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSN-GQVITTERLDRENPLEgdVSIFVRALDGG 2578
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1622865855 2579 G--RTTFCTVRVIVVDENDN 2596
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1171-1252 2.60e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 2.60e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRkLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDN 1250
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1622865855  1251 KP 1252
Cdd:smart00112   80 AP 81
LamG smart00282
Laminin G domain;
3860-3994 3.64e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 97.80  E-value: 3.64e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3860 KLALRLRTLQSNGIIMYTRANP---CIILKIVDGKLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDS 3936
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggdYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865855  3937 YVERRRAPLYFQTLSTESSIYFGALVQADNIRSLTDTrvtqvlSGFQGCLDSVILNNN 3994
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT------PGFRGCIRNLKVNGK 132
Cadherin pfam00028
Cadherin domain;
1049-1139 6.65e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 6.65e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETTGSYWLTVYATDRGVVPL 1128
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1622865855 1129 YSTIEVYIEVE 1139
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3346-3436 9.07e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 9.07e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3346 YSTVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPP 3425
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1622865855 3426 MSSTATLNIDI 3436
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2837-2922 3.05e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.57  E-value: 3.05e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  2837 RAIDMDWGANGQVTYSLHSDSQPEKvmeaFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAfSLSSTALVSVRVTD 2916
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLD 75


                    ....*.
gi 1622865855  2917 INDNAP 2922
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1799-1881 3.74e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 3.74e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  1799 RATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTaeSPVEVNIEVTDVND 1878
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS--STATVTITVLDVND 78


                    ...
gi 1622865855  1879 NPP 1881
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2928-3025 5.62e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 5.62e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2928 VYRGNVKESDPPGEVVAVLSTWDRDtSDINRQVSYHITGGNPRGRFALGlvQSEWKVYVKRPLDREEQDIYFLNITATDG 3007
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSID--PSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1622865855 3008 ---LFVTQAMVEVSVSDVNDN 3025
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 749-829 9.53e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 9.53e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   749 KAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNS 828
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1622865855   829 P 829
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3135-3232 1.26e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 1.26e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3135 HYNACIYENTATKALLTRVQAVDPDVGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSpG 3213
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                           90
                   ....*....|....*....
gi 1622865855 3214 QSLSSLTTVTITVLDINDN 3232
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1157-1245 1.17e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 1.17e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1157 VMENSPKDISVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRkLDREQQAEHFLEVTVTDGGPSPKQS 1236
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1622865855 1237 TIWVVVQVL 1245
Cdd:pfam00028   84 TATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2088-2179 1.86e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 1.86e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2088 PYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNiEYGVTILAKDGGK 2165
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1622865855 2166 PSLSTSVELPITIV 2179
Cdd:cd11304     80 PPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2312-2392 2.25e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 2.25e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  2312 IDADSENNKMVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSTDSGFPSLSSEVLVHIYISDVNDNP 2391
Cdd:smart00112    3 TDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1622865855  2392 P 2392
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-576 4.00e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 4.00e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   495 SASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEiYRFIVRASDWGSPyRHESEVNVTIRIGNVND 573
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1622865855   574 NSP 576
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
477-568 9.60e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.59  E-value: 9.60e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  477 YDANVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FAINQFTGVISTTEELDFEsSPEIYRFIVRASDWGSP 555
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1622865855  556 YRhESEVNVTIRI 568
Cdd:pfam00028   80 PL-SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3052-3129 1.10e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 1.10e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3052 SAKDADIGSNGDIRYSL-YGSGNSEFFLDPESGELKTLALLDRERVPVYSLMAKATDGGG--RFCQANIHLILEDVNDNP 3128
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNA 80


                    .
gi 1622865855  3129 P 3129
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1258-1348 1.16e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 1.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1258 VYQIKLPERDrkKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 1334
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1622865855 1335 GRPQKSSTARLHIE 1348
Cdd:cd11304     78 GGPPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 855-934 3.76e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 3.76e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   855 ARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAesGQQLFSVVTLKVFLDDVNDC 932
Cdd:smart00112    2 ATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1622865855   933 SP 934
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2604-2699 7.01e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 7.01e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2604 EYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEasvSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDG 2683
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1622865855 2684 GIPVKHSLIPVYIHVL 2699
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2398-2490 1.16e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.16e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2398 IYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG--- 2474
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*.
gi 1622865855 2475 LFTSTAQVHIRVLGAN 2490
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3451-3542 1.36e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.52  E-value: 1.36e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3451 YTAVIQENKPVGTSILQLVVTDRDSFHNGpPFSFSILSGNEEEEFVLDSH-GILRSAVVFQHTESLEYVLCVQAKDSGKP 3529
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1622865855 3530 QQVSHTYIRVRVI 3542
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
941-1018 2.04e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 2.04e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855  941 YSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR-FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
1571-1662 2.40e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 2.40e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1571 YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNTFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPP 1650
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1622865855 1651 MSATAIVRISVT 1662
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1699-1767 2.53e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 2.53e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622865855  1699 STLIYEVKDGDINGIFTINPYSGVITTRKVLDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAP 1767
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3154-3234 3.08e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 3.08e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3154 QAVDPDVGINRKVVYSLAD-SAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSpGQSLSSLTTVTITVLDINDN 3232
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1622865855  3233 PP 3234
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
2501-2590 1.09e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.09e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2501 YVAEVRENAAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPleGDVSIFVRALDGGG 2579
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|.
gi 1622865855 2580 RTTFCTVRVIV 2590
Cdd:pfam00028   79 PPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
836-924 1.25e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  836 YSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDT--QQFAINSSTGIVYVADQLDRESKANYSLKIEARDkaESG 913
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD--SGG 78

                           90
                   ....*....|.
gi 1622865855  914 QQLFSVVTLKV 924
Cdd:pfam00028   79 PPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
1774-1872 1.67e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 1.67e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1774 YSGSLSEAAPINSIVrsldnspLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHV 1853
Cdd:pfam00028    1 YSASVPENAPVGTEV-------LTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 1622865855 1854 RDSGSPQLTAESPVEVNIE 1872
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1676-1759 3.85e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 3.85e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1676 YQAEVNENVDIGTSVILISAIS-----QSTLIYEVKDGDINGIFTINPYSGVITTRKVLDYERTSSYQLIIQATNMA--G 1748
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|.
gi 1622865855 1749 MASNATVNIQI 1759
Cdd:pfam00028   81 LSSTATVTITV 91
Laminin_G_1 pfam00054
Laminin G domain;
3866-3996 1.04e-16

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 79.28  E-value: 1.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3866 RTLQSNGIIMYTRANP---CIILKIVDGKLWFQLDCGSGPGILGISGRaVNDGSWHSVFLELNRNFTSLSLDDSYVERRR 3942
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTerdFLALELRDGRLEVSYDLGSGAAVVRSGDK-LNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622865855 3943 APL-YFQTLSTESSIYFGALVqadniRSLTDTRVTQVLSGFQGCLDSVILNNNEL 3996
Cdd:pfam00054   81 SPLgATTDLDVDGPLYVGGLP-----SLGVKKRRLAISPSFDGCIRDVIVNGKPL 130
Cadherin pfam00028
Cadherin domain;
2819-2915 1.10e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.10e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2819 YDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKvmeaFNIDSNTGWISTLKDLDHETDPTFTFSVVASDL 2898
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN----FRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*..
gi 1622865855 2899 GEAfSLSSTALVSVRVT 2915
Cdd:pfam00028   77 GGP-PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2191-2283 1.57e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 1.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2191 YTASVNEDIRMNTPILSINATSPEGQGIIYII---IDGDPFKQFNVDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGA 2267
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTysiVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1622865855 2268 R-AEVTVDLLVNDVNDN 2283
Cdd:cd11304     82 LsSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2292-2384 7.14e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 7.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2292 YNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDtyNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSTDSGF 2371
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1622865855 2372 PSLSSEVLVHIYI 2384
Cdd:pfam00028   79 PPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
733-822 8.51e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 8.51e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1622865855  813 SWRLLTINVE 822
Cdd:pfam00028   83 STATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1465-1557 1.17e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 1.17e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1465 YDVTISEDVLPDTEILQIEATDRDEK--HKLSYTVhssIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1542
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1622865855 1543 FPYRRNLARVIVNVE 1557
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2519-2598 1.28e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.69  E-value: 1.28e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  2519 RATDGDPGTYGQISYAIINDFAKDRFLIDSN-GQVITTERLDRENplEGDVSIFVRALDGGG--RTTFCTVRVIVVDEND 2595
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREE--QPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                    ...
gi 1622865855  2596 NAP 2598
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1484-1564 2.76e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 2.76e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  1484 ATDRDE--KHKLSYTVHSSIDSismRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDAND 1561
Cdd:smart00112    2 ATDADSgeNGKVTYSILSGNDD---GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1622865855  1562 HSP 1564
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
1259-1348 2.77e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 2.77e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1259 YQIKLPERDRkkRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDNG 1335
Cdd:pfam00028    1 YSASVPENAP--VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdreSIGEY-ELTVEATDSG 77

                           90
                   ....*....|...
gi 1622865855 1336 RPQKSSTARLHIE 1348
Cdd:pfam00028   78 GPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
3136-3227 2.93e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 2.93e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3136 YNACIYENTATKALLTRVQAVDPDVGINRKVVYS-LADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSpGQ 3214
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                           90
                   ....*....|...
gi 1622865855 3215 SLSSLTTVTITVL 3227
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1367-1456 4.45e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 4.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1367 YNFTVMESDRVTEIVGVVSVQ----PANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN-- 1440
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1622865855 1441 -VAVTQVFIKVLDNNDN 1456
Cdd:cd11304     82 lSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-264 6.77e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 6.77e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   181 TATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKlygnnGVSSTAKLYVHIER 258
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-----PLSSTATVTITVLD 75


                    ....*.
gi 1622865855   259 INEHAP 264
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1280-1348 8.39e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 8.39e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622865855  1280 AFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYDiLTIKAVDNGRPQKSSTARLHIE 1348
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2950-3027 1.10e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.10e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  2950 DRDtSDINRQVSYHITGGNPRGRFALGLVQSEwkVYVKRPLDREEQDIYFLNITATDG---LFVTQAMVEVSVSDVNDNS 3026
Cdd:smart00112    4 DAD-SGENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 1622865855  3027 P 3027
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1589-1667 1.11e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.11e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  1589 TALDKDKGENAELIYTIEAGNTGNTFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVT-MSDNS 1667
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLdVNDNA 80
Cadherin pfam00028
Cadherin domain;
163-257 1.43e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 1.43e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  163 YSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmkl 240
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*..
gi 1622865855  241 yGNNGVSSTAKLYVHIE 257
Cdd:pfam00028   77 -GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-468 1.58e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 1.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  380 VYDVSVSEFSPPGVVVAIVKL----SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTAQPLNTVKKEVYKLEVTNKEGDL- 454
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1622865855  455 ----KTQVTISIEDANDH 468
Cdd:cd11304     81 plssTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3034-3122 2.14e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 2.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSEFF-LDPESGELKTLALLDRERVPVYSLMAKATDGG--G 3110
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFrIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 1622865855 3111 RFCQANIHLILE 3122
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 961-1018 2.89e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 2.89e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855   961 HDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:smart00112    3 TDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP 61
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1898-1977 1.80e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.88  E-value: 1.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDG---KFYSTSMVTIM 1971
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKplDREEQSSYTLTVTATDGggpPLSSTATVTIT 91


                   ....*.
gi 1622865855 1972 VKEAMD 1977
Cdd:cd11304     92 VLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1987-2080 5.05e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 5.05e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1987 YSTSISENNTNITKVAIVNAV--GNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASRELDY 2062
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1622865855 2063 LRVARVVVRVNIEDINDN 2080
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2089-2178 5.12e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 5.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2089 YYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNiEYGVTILAKDGGKP 2166
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIG-EYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1622865855 2167 SLSTSVELPITI 2178
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2224-2285 8.37e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 8.37e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622865855  2224 DGDPFKQFNVDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGAR-AEVTVDLLVNDVNDNPP 2285
Cdd:smart00112   19 SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLsSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2712-2810 3.09e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 3.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2712 QYSFTIAEDTAIGSTVDTLR-----ILPSQNVRFSTVNGerpenNKGGVFVIEQETGTIKLDKRLDHETSPAFHFKVAAT 2786
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSatdpdSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....*.
gi 1622865855 2787 iplDKVDIVFA--VDVDIKVLDLNDN 2810
Cdd:cd11304     76 ---DGGGPPLSstATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2191-2276 9.61e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 9.61e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2191 YTASVNEDIRMNTPILSINAT---SPEGQGIIYIIIDGDPFKQFNVDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGA 2267
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1622865855 2268 R---AEVTVDLL 2276
Cdd:pfam00028   81 LsstATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2605-2699 1.16e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2605 YRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGG 2684
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1622865855 2685 IPVKHSLIPVYIHVL 2699
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1387-1458 2.22e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.37  E-value: 2.22e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865855  1387 QPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN---VAVTQVFIKVLDNNDNGP 1458
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGpplSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 592-672 1.24e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  592 PVGGHITAVSAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSgiKNGNFALRITATDGEN--LADPMSI 667
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1622865855  668 NISVL 672
Cdd:cd11304     89 TITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2107-2179 3.01e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.29  E-value: 3.01e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865855  2107 TAIDKDKGPNGEVTYVL--QDDYGHFEINPNSGNVILKEAFNSDLSNiEYGVTILAKDGGKPSLSTSVELPITIV 2179
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQP-EYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 401-470 4.11e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 4.11e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865855   401 SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTAQPLNTVKKEVYKLEVTNKEGDLK-----TQVTISIEDANDHTP 470
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplsstATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2623-2699 5.56e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 5.56e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865855  2623 QAIDPDDGANSRITYSLyseASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVL 2699
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
3451-3542 7.22e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 7.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3451 YTAVIQENKPVGTSILQLVVTDRDSFHNGPPFsFSILSGNEEEEFVLDSH-GILRSAVVFQHTESLEYVLCVQAKDSGKP 3529
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1622865855 3530 QQVSHTYIRVRVI 3542
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3469-3549 8.54e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.13  E-value: 8.54e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  3469 VVTDRDSFHNGPpFSFSILSGNEEEEFVLDSH-GILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTH 3547
Cdd:smart00112    1 SATDADSGENGK-VTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1622865855  3548 KP 3549
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2417-2490 1.33e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 1.33e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855  2417 QASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNH--RKQRmePLYSLNVSVSDG---LFTSTAQVHIRVLGAN 2490
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPldREEQ--PEYTLTVEATDGggpPLSSTATVTITVLDVN 77
Cadherin pfam00028
Cadherin domain;
2399-2487 2.51e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 2.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2399 YESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNH--RKQRmePLYSLNVSVSDGLF 2476
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPldRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1622865855 2477 ---TSTAQVHIRVL 2487
Cdd:pfam00028   79 pplSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2929-3007 2.59e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 2929 YRGNVKESDPPGEVVAVLSTWDRDTSDiNRQVSYHITGGNPRGRFAL----GLVqsewkvYVKRPLDREEQDIYFLNITA 3004
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRIdpdtGDI------STTKPLDRESIGEYELTVEA 73


                   ...
gi 1622865855 3005 TDG 3007
Cdd:pfam00028   74 TDS 76
Cadherin pfam00028
Cadherin domain;
1987-2057 7.57e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 7.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865855 1987 YSTSISENNTNITKVAIVNAV----GnrLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEAS 2057
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlG--PNGRIFYSILggGPGGNFRIDPDTGDISTTK-PLDRESIGEYELTVEAT 74
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3561-3638 1.74e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3561 MEDDFPGGVIGKIHATDQD--MYDVLTFALKSEQ-KSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSDG---RFQVPI 3631
Cdd:cd11304      7 PENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDreeQSSYTLTVTATDGggpPLSSTA 86


                   ....*..
gi 1622865855 3632 DVVVHVE 3638
Cdd:cd11304     87 TVTITVL 93
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4023-4058 2.01e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 2.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1622865855 4023 DACE-RSPCQHGGSCTGLPsGGYQCTCLSQFTGRNCE 4058
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2012-2082 2.19e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 2.19e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622865855  2012 NEPLKYSIL--NPGNKFKIKSTSGVIQTTGvPFDREEQELYELVVEASRELDYLRVARVVVRVNIEDINDNSP 2082
Cdd:smart00112   10 NGKVTYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-153 2.87e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.24  E-value: 2.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855   47 IYNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNR 119
Cdd:cd11304      1 SYEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDR 62

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1622865855  120 EIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMND 153
Cdd:cd11304     63 EEQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
1367-1451 5.43e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 5.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1367 YNFTVMESDRVTEIVGVVSVQ----PANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN-- 1440
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpp 80

                           90
                   ....*....|..
gi 1622865855 1441 -VAVTQVFIKVL 1451
Cdd:pfam00028   81 lSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
592-672 1.72e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  592 PVGGHITAVSAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSLtnSGIKNGNFALRITATD--GENLADPMSI 667
Cdd:pfam00028   10 PVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDsgGPPLSSTATV 87


                   ....*
gi 1622865855  668 NISVL 672
Cdd:pfam00028   88 TITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2734-2812 2.65e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 2.65e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  2734 PSQNVRFSTVNGerpenNKGGVFVIEQETGTIKLDKRLDHETSPAFHFKVAATiplDKVDIVFA--VDVDIKVLDLNDNK 2811
Cdd:smart00112    9 ENGKVTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEAT---DGGGPPLSstATVTITVLDVNDNA 80


                    .
gi 1622865855  2812 P 2812
Cdd:smart00112   81 P 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4057-4096 4.19e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 4.19e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622865855 4057 CESeitacfPNPCRNGGSCDPIGNTFICNCKAGLTGVTCE 4096
Cdd:cd00054      5 CAS------GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4064-4092 7.17e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 48.15  E-value: 7.17e-07
                           10        20
                   ....*....|....*....|....*....
gi 1622865855 4064 CFPNPCRNGGSCDPIGNTFICNCKAGLTG 4092
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
4023-4058 2.34e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 2.34e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1622865855  4023 DACE-RSPCQHGGSCTGLPsGGYQCTCLSQFT-GRNCE 4058
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
2713-2786 3.64e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 3.64e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855 2713 YSFTIAEDTAIGSTVDTLRIL-----PSQNVRFSTVNGERpennkGGVFVIEQETGTIKLDKRLDHETSPAFHFKVAAT 2786
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlgPNGRIFYSILGGGP-----GGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1906-1977 4.60e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 4.60e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855  1906 SATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTIkNNNL---SKDHYMLIVKVSDG---KFYSTSMVTIMVKEAMD 1977
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITT-TKPLdreEQPEYTLTVEATDGggpPLSSTATVTITVLDVND 78
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 76-156 4.97e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 4.97e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855    76 SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDM 151
Cdd:smart00112   10 NGKVTYSILSGNDDGLF-------------SIDPETGEittTKPLDREEQPEYTLTVEATDGGGPpLSSTATVTITVLDV 76


                    ....*
gi 1622865855   152 NDLRP 156
Cdd:smart00112   77 NDNAP 81
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4025-4058 6.08e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 45.55  E-value: 6.08e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1622865855 4025 CERS-PCQHGGSCTGLPsGGYQCTCLSQFTG-RNCE 4058
Cdd:cd00053      2 CAASnPCSNGGTCVNTP-GSYRCVCPPGYTGdRSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4110-4133 6.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 6.92e-06
                           10        20
                   ....*....|....*....|....
gi 1622865855 4110 GGSCVNVFGSFLCNCTPGYVGQYC 4133
Cdd:cd00054     14 GGTCVNTVGSYRCSCPPGYTGRNC 37
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 601-672 2.22e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.42  E-value: 2.22e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865855   601 SAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSgiKNGNFALRITATDGEN--LADPMSINISVL 672
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDGGGppLSSTATVTITVL 74
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4066-4096 4.63e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 43.23  E-value: 4.63e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622865855 4066 PNPCRNGGSCDPIGNTFICNCKAGLTGV-TCE 4096
Cdd:cd00053      5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
Cadherin pfam00028
Cadherin domain;
1898-1972 1.05e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.83  E-value: 1.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGSLDH-FLIDSNSGVLTIKnNNL---SKDHYMLIVKVSDGKFY---STSMVTI 1970
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTT-KPLdreSIGEYELTVEATDSGGPplsSTATVTI 89


                   ..
gi 1622865855 1971 MV 1972
Cdd:pfam00028   90 TV 91
EGF_CA smart00179
Calcium-binding EGF-like domain;
4057-4096 1.16e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 1.16e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1622865855  4057 CESeitacfPNPCRNGGSCDPIGNTFICNCKAGLT-GVTCE 4096
Cdd:smart00179    5 CAS------GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
381-463 2.72e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.67  E-value: 2.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855  381 YDVSVSEFSPPGVVVAIVKL----SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTAQPLNTVKKEVYKLEVTNKEGDLK- 455
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPp 80

                           90
                   ....*....|..
gi 1622865855  456 ----TQVTISIE 463
Cdd:pfam00028   81 lsstATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1050-1144 4.05e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.33  E-value: 4.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1050 GSVKENSRIGTSVLQV-TARDEDSGRDGEIQYSIRDgSGLGRFSIDDESGVITAADILDRETTGSYWLTVYATDRGVVPL 1128
Cdd:cd00031      4 GSAVEGRSRGSFRVSIpTDLIASSGEIIKISAAGKE-ALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                           90
                   ....*....|....*.
gi 1622865855 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd00031     83 QTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
283-357 4.40e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 4.40e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622865855  283 AVVTVDDLDDGANGEIeSVSIVAGDPLDQFFLAKEGKWlneykIKERKQIDWESFPYgYNLTLQAKDKGSPQKFS 357
Cdd:pfam00028   16 LTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDTGD-----ISTTKPLDRESIGE-YELTVEATDSGGPPLSS 83
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4025-4056 5.32e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 5.32e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622865855 4025 CERSPCQHGGSCTGLPsGGYQCTCLSQFTGRN 4056
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 286-364 8.00e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 8.00e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622865855   286 TVDDLDDGANGEIeSVSIVAGDPLDQFFLAKEGKWlneykIKERKQIDWESFPYgYNLTLQAKDKGSPQKfSALKAVHI 364
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPL-SSTATVTI 71
Cadherin_3 pfam16184
Cadherin-like;
1131-1194 8.69e-04

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 41.82  E-value: 8.69e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865855 1131 TIEVYIEVEDVNDNAPL--TSEPIYypvVMENSPKDISVIQIQAEDPDsSSNEKLTYRITSGnPQN 1194
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVltTNTGLR---LWEGSSRPITPDLLQAEDPD-TPPEDLTYTVVQG-PSH 64
EGF_CA smart00179
Calcium-binding EGF-like domain;
4110-4133 8.99e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 8.99e-04
                            10        20
                    ....*....|....*....|....*
gi 1622865855  4110 GGSCVNVFGSFLCNCTPGYV-GQYC 4133
Cdd:smart00179   14 GGTCVNTVGSYRCECPPGYTdGRNC 38
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3034-3127 1.76e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.79  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 3034 YTALLPEDIPSNKIILKvsakdADIGSNGDIRYSLYGSGN----SEFFLDPESGELKTLALLDRERVPVYSLMAKATDGG 3109
Cdd:cd00031      4 GSAVEGRSRGSFRVSIP-----TDLIASSGEIIKISAAGKealpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                           90       100
                   ....*....|....*....|
gi 1622865855 3110 GRFCQANIHLILE--DVNDN 3127
Cdd:cd00031     79 ANVPQTSSVFSIEvyDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1805-1879 2.43e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.41  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865855 1805 SNRNALL--VYQIVESTAKK---FFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPqlTAESPVEVNIEVTDVNDN 1879
Cdd:cd00031     21 TDLIASSgeIIKISAAGKEAlpsWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGAN--VPQTSSVFSIEVYDENDN 98
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4110-4133 2.73e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 2.73e-03
                           10        20
                   ....*....|....*....|....*
gi 1622865855 4110 GGSCVNVFGSFLCNCTPGYVGQ-YC 4133
Cdd:cd00053     11 GGTCVNTPGSYRCVCPPGYTGDrSC 35
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 4069-4089 3.23e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 37.70  E-value: 3.23e-03
                           10        20
                   ....*....|....*....|.
gi 1622865855 4069 CRNGGSCDPIGNTFICNCKAG 4089
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPG 21
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 4110-4128 7.88e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 7.88e-03
                           10
                   ....*....|....*....
gi 1622865855 4110 GGSCVNVFGSFLCNCTPGY 4128
Cdd:pfam12661    4 GGTCVDGVNGYKCQCPPGY 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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