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Conserved domains on  [gi|966921093|ref|XP_014967971|]
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leucine-rich repeat-containing protein 71 isoform X3 [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 138-306 1.16e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 94.86  E-value: 1.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 138 KSVKEIYIRGWKVEERILGIFSKCLPPLTQLQAINFWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYH---K 214
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG-NKSLTTLDLSNNQIGDEGVIalaE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 215 LMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQD 294
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGA 334

                        170
                 ....*....|..
gi 966921093 295 KGALKLAEVLRA 306
Cdd:COG5238  335 QGAIALAKALQE 346
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 138-306 1.16e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 94.86  E-value: 1.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 138 KSVKEIYIRGWKVEERILGIFSKCLPPLTQLQAINFWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYH---K 214
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG-NKSLTTLDLSNNQIGDEGVIalaE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 215 LMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQD 294
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGA 334

                        170
                 ....*....|..
gi 966921093 295 KGALKLAEVLRA 306
Cdd:COG5238  335 QGAIALAKALQE 346
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 137-308 4.46e-15

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 76.24  E-value: 4.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 137 SKSVKEIYIRGWKVEERILGIFSKCLPPLT-QLQAINFWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYHKL 215
Cdd:cd00116  107 SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRA-NRDLKELNLANNGIGDAGIRAL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 216 ---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLR-LNRSLLWLSLAHNR 291
Cdd:cd00116  186 aegLKANCNLEVLDLNNNGLTDEGASALAETLAS----LKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCND 261

                        170
                 ....*....|....*..
gi 966921093 292 IQDKGALKLAEVLRAFE 308
Cdd:cd00116  262 ITDDGAKDLAEVLAEKE 278
LRR_6 pfam13516
Leucine Rich repeat;
251-273 2.05e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 38.37  E-value: 2.05e-04
                          10        20
                  ....*....|....*....|...
gi 966921093  251 NRTLVSLNLGFNHIGDEGAGYIA 273
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
279-306 2.64e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.16  E-value: 2.64e-04
                           10        20
                   ....*....|....*....|....*...
gi 966921093   279 NRSLLWLSLAHNRIQDKGALKLAEVLRA 306
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 138-306 1.16e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 94.86  E-value: 1.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 138 KSVKEIYIRGWKVEERILGIFSKCLPPLTQLQAINFWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYH---K 214
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG-NKSLTTLDLSNNQIGDEGVIalaE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 215 LMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQD 294
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGA 334

                        170
                 ....*....|..
gi 966921093 295 KGALKLAEVLRA 306
Cdd:COG5238  335 QGAIALAKALQE 346
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 137-304 3.90e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 80.60  E-value: 3.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 137 SKSVKEIYIRGWKVEERILGIFSKCLPPLTQLQAINFWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQ---SYH 213
Cdd:COG5238  207 NTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKN-NTTVETLYLSGNQIGAEgaiALA 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 214 KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQ 293
Cdd:COG5238  286 KALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG----NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIG 361

                        170
                 ....*....|.
gi 966921093 294 DKGALKLAEVL 304
Cdd:COG5238  362 DEGAIALAKYL 372
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 137-308 4.46e-15

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 76.24  E-value: 4.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 137 SKSVKEIYIRGWKVEERILGIFSKCLPPLT-QLQAINFWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYHKL 215
Cdd:cd00116  107 SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRA-NRDLKELNLANNGIGDAGIRAL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 216 ---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLR-LNRSLLWLSLAHNR 291
Cdd:cd00116  186 aegLKANCNLEVLDLNNNGLTDEGASALAETLAS----LKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCND 261

                        170
                 ....*....|....*..
gi 966921093 292 IQDKGALKLAEVLRAFE 308
Cdd:cd00116  262 ITDDGAKDLAEVLAEKE 278
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 159-307 5.53e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 70.08  E-value: 5.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 159 SKCLPPLTQLQAINFWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYHKL-MALDSTIA--HLSLRNNNIDDR 235
Cdd:cd00116  158 AKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALaETLASLKSleVLNLGDNNLTDA 236

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966921093 236 GAQLLGQALSTLhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRAF 307
Cdd:cd00116  237 GAAALASALLSP---NISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEP 305
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 135-308 6.91e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 64.43  E-value: 6.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 135 EDSKSVKEIYIRGWKVEERILGIFSKCLPPLTQLQAINFWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYHK 214
Cdd:COG5238  261 KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIA 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 215 L---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRsLLWLSLAHNR 291
Cdd:COG5238  340 LakaLQENTTLHSLDLSDNQIGDEGAIALAKYLEG----NTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNL 414

                        170
                 ....*....|....*..
gi 966921093 292 IQDKGALKLAEVLRAFE 308
Cdd:COG5238  415 IGAEAQQRLEQLLERIK 431
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 162-305 8.14e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 63.53  E-value: 8.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 162 LPPLTQLQAINFWKVGLTD-------KTLTTFIELLPLCSST----------------------LRKVSLEGNPLPEQSY 212
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakalaSALRPQPSLKELCLSLnetgriprglqsllqgltkgcgLQELDLSDNALGPDGC 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 213 HKLMAL--DSTIAHLSLRNNNIDDRGAQLLGQAL-------------------------STLHSCNRTLVSLNLGFNHIG 265
Cdd:cd00116   99 GVLESLlrSSSLQELKLNNNGLGDRGLRLLAKGLkdlppaleklvlgrnrlegascealAKALRANRDLKELNLANNGIG 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 966921093 266 DEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 305
Cdd:cd00116  179 DAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLA 218
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 218-305 1.07e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.66  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 218 LDSTIAHLSLRNNNIDDRGAQLLGQALS---TLHSC---------------------NRTLVSLNLGFNHIGDEGAGYIA 273
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTqntTVTTLwlkrnpigdegaeilaealkgNKSLTTLDLSNNQIGDEGVIALA 257

                         90       100       110
                 ....*....|....*....|....*....|..
gi 966921093 274 DGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 305
Cdd:COG5238  258 EALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
138-389 1.23e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 138 KSVKEIYIRGWKVEErilgiFSKCLPPLTQLQAINFWKVGLTDktLTTFIELLPlcssTLRKVSLEGNPLPEQSYH--KL 215
Cdd:COG4886  136 TNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD--LPEELGNLT----NLKELDLSNNQITDLPEPlgNL 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 216 MALDStiahLSLRNNNIDDrgaqlLGQALSTLHScnrtLVSLNLGFNHIGDegagyiADGLRLNRSLLWLSLAHNRIQDK 295
Cdd:COG4886  205 TNLEE----LDLSGNQLTD-----LPEPLANLTN----LETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTDL 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 296 GALKLAEVLRAFELTHTEVVERRRLLLEKGTQERSRSPSSSRHGDSKTDREKSQMVGISNSALVDKTDKTQTMKTPKGLG 375
Cdd:COG4886  266 PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                        250
                 ....*....|....
gi 966921093 376 KKKEKSWELAKKEE 389
Cdd:COG4886  346 LLALLTLLLLLNLL 359
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 236-305 1.52e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.48  E-value: 1.52e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966921093 236 GAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 305
Cdd:COG5238  164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALK 233
LRR_6 pfam13516
Leucine Rich repeat;
251-273 2.05e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 38.37  E-value: 2.05e-04
                          10        20
                  ....*....|....*....|...
gi 966921093  251 NRTLVSLNLGFNHIGDEGAGYIA 273
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
279-306 2.64e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.16  E-value: 2.64e-04
                           10        20
                   ....*....|....*....|....*...
gi 966921093   279 NRSLLWLSLAHNRIQDKGALKLAEVLRA 306
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
251-277 1.50e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 1.50e-03
                           10        20
                   ....*....|....*....|....*..
gi 966921093   251 NRTLVSLNLGFNHIGDEGAGYIADGLR 277
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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