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Conserved domains on  [gi|966980026|ref|XP_014967286|]
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kelch-like protein 29 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 312-438 2.25e-83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18258:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 125  Bit Score: 262.99  E-value: 2.25e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 312 PREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGqgGREKLELVLSNLQADVLELLLEF 391
Cdd:cd18258    1 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSG--GGEKLELTMSNINADVLELLLEF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966980026 392 VYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18258   79 VYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 432-533 2.02e-62

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


:

Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 205.34  E-value: 2.02e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 432 TASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPAT 511
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|..
gi 966980026 512 RTQYAAELLAVVRLPFIHPSYL 533
Cdd:cd18468   81 RKQHIAELLAVVRLPFIHPSYL 102
PHA03098 super family cl33709
kelch-like protein; Provisional
 333-860 1.50e-46

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 174.96  E-value: 1.50e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 333 IVVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqggreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAAS 412
Cdd:PHA03098  16 IVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---------NEINLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIAN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 413 KFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTK 492
Cdd:PHA03098  87 YLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 493 AEELVYETVIKWIKKDPATRTQYAAELLAVVRlpfihPSYLlnvvdNEELIKSSEACRdLVNEAKRYhmlPHARQEMQTP 572
Cdd:PHA03098 167 SEDVVLEIIIKWLTSKKNNKYKDICLILKVLR-----ITFL-----SEEGIKKLKRWK-LRIKKKKI---VFNKRCIKII 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 573 RTRPRLSAGVAEVIVLVGG-RQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFydREFFSVVSAGDNIYLSGGM-ESGVTL 650
Cdd:PHA03098 233 YSKKYNLNKILPRSSTFGSiIYIHITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMnKNNLSV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 651 ADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-----AYARATTI--YDPEKGNIKA 803
Cdd:PHA03098 391 LIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidNIKVYNIVesYNPVTNKWTE 470

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966980026 804 GPNMNHSRQFCSAVVLDGKIYATGGIvsSEGPALGNMEAYEPTTNTWTLLpHMPCPV 860
Cdd:PHA03098 471 LSSLNFPRINASLCIFNNKIYVVGGD--KYEYYINEIEVYDDKTNTWTLF-CKFPKV 524
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 49-290 7.84e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.03  E-value: 7.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   49 ARPGLLPLPVVPSRlPTPATAPApctTGSSEAITSLVASSASAVTTKAPgiSKADSQSQGLATSIRWGQTPINQsTPWDT 128
Cdd:PHA03247 2755 ARPARPPTTAGPPA-PAPPAAPA---AGPPRRLTRPAVASLSESRESLP--SPWDPADPPAAVLAPAAALPPAA-SPAGP 2827

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  129 DEPPSKQMRESDNPGTGPWVTTVAAGNQ--PTLIAHSYGVAQPPTFSPAVNVQAPVIGVT---PSLPPHVGPQLPLMPGH 203
Cdd:PHA03247 2828 LPPPTSAQPTAPPPPPGPPPPSLPLGGSvaPGGDVRRRPPSRSPAAKPAAPARPPVRRLArpaVSRSTESFALPPDQPER 2907

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  204 YSLPQPPSQPLSSVVVNMPAQALYASPQ------PLAVSTLPGVGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSG 277
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPQPQPPPPPpprpqpPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSRE 2987

                         250
                  ....*....|...
gi 966980026  278 APATNGPPTTDSA 290
Cdd:PHA03247 2988 APASSTPPLTGHS 3000
 
Name Accession Description Interval E-value
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 312-438 2.25e-83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 262.99  E-value: 2.25e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 312 PREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGqgGREKLELVLSNLQADVLELLLEF 391
Cdd:cd18258    1 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSG--GGEKLELTMSNINADVLELLLEF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966980026 392 VYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18258   79 VYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 432-533 2.02e-62

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 205.34  E-value: 2.02e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 432 TASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPAT 511
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|..
gi 966980026 512 RTQYAAELLAVVRLPFIHPSYL 533
Cdd:cd18468   81 RKQHIAELLAVVRLPFIHPSYL 102
PHA03098 PHA03098
kelch-like protein; Provisional
 333-860 1.50e-46

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 174.96  E-value: 1.50e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 333 IVVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqggreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAAS 412
Cdd:PHA03098  16 IVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---------NEINLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIAN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 413 KFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTK 492
Cdd:PHA03098  87 YLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 493 AEELVYETVIKWIKKDPATRTQYAAELLAVVRlpfihPSYLlnvvdNEELIKSSEACRdLVNEAKRYhmlPHARQEMQTP 572
Cdd:PHA03098 167 SEDVVLEIIIKWLTSKKNNKYKDICLILKVLR-----ITFL-----SEEGIKKLKRWK-LRIKKKKI---VFNKRCIKII 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 573 RTRPRLSAGVAEVIVLVGG-RQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFydREFFSVVSAGDNIYLSGGM-ESGVTL 650
Cdd:PHA03098 233 YSKKYNLNKILPRSSTFGSiIYIHITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMnKNNLSV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 651 ADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-----AYARATTI--YDPEKGNIKA 803
Cdd:PHA03098 391 LIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidNIKVYNIVesYNPVTNKWTE 470

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966980026 804 GPNMNHSRQFCSAVVLDGKIYATGGIvsSEGPALGNMEAYEPTTNTWTLLpHMPCPV 860
Cdd:PHA03098 471 LSSLNFPRINASLCIFNNKIYVVGGD--KYEYYINEIEVYDDKTNTWTLF-CKFPKV 524
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
615-872 3.56e-44

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 161.09  E-value: 3.56e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 615 WYPLASLPFyDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRcRHNS--LVYDGKIYTLGGLG 692
Cdd:COG3055    3 WSSLPDLPT-PRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPP-RHHAaaVAQDGKLYVFGGFT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 693 VAGN----VDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVlQSYVPQTNTWSFIES-PMID 767
Cdd:COG3055   81 GANPsstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWV-EVYDPATGTWTQLAPlPTPR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 768 NKYAPAVTLNGFVFILGGAYarattiYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGivssEGPALGNMEAYEPTT 847
Cdd:COG3055  160 DHLAAAVLPDGKILVIGGRN------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG----ESGFSDEVEAYDPAT 229

                        250       260
                 ....*....|....*....|....*
gi 966980026 848 NTWTLLPHMPCPVFRHGCVVIKKYI 872
Cdd:COG3055  230 NTWTALGELPTPRHGHAAVLTDGKV 254
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 436-537 1.38e-38

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 138.83  E-value: 1.38e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  436 CLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQY 515
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 966980026  516 AAELLAVVRLPFIHPSYLLNVV 537
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 436-536 5.65e-32

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 119.75  E-value: 5.65e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   436 CLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQY 515
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 966980026   516 AAELLAVVRLPFIHPSYLLNV 536
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 319-431 3.00e-24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 98.10  E-value: 3.00e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggrEKLELVLSNLQADVLELLLEFVYTGSLv 398
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESES-----SVSEITLDDVSPEDFEALLEFMYTGKL- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 966980026  399 IDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:pfam00651  75 ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 330-431 1.13e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 87.36  E-value: 1.13e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   330 DLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLE 409
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFS-----SDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLE 75

                           90       100
                   ....*....|....*....|..
gi 966980026   410 AASKFQFHTFCKVCVSFLEKQL 431
Cdd:smart00225  76 LADYLQIPGLVELCEEFLLKLL 97
PHA03247 PHA03247
large tegument protein UL36; Provisional
 49-290 7.84e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.03  E-value: 7.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   49 ARPGLLPLPVVPSRlPTPATAPApctTGSSEAITSLVASSASAVTTKAPgiSKADSQSQGLATSIRWGQTPINQsTPWDT 128
Cdd:PHA03247 2755 ARPARPPTTAGPPA-PAPPAAPA---AGPPRRLTRPAVASLSESRESLP--SPWDPADPPAAVLAPAAALPPAA-SPAGP 2827

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  129 DEPPSKQMRESDNPGTGPWVTTVAAGNQ--PTLIAHSYGVAQPPTFSPAVNVQAPVIGVT---PSLPPHVGPQLPLMPGH 203
Cdd:PHA03247 2828 LPPPTSAQPTAPPPPPGPPPPSLPLGGSvaPGGDVRRRPPSRSPAAKPAAPARPPVRRLArpaVSRSTESFALPPDQPER 2907

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  204 YSLPQPPSQPLSSVVVNMPAQALYASPQ------PLAVSTLPGVGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSG 277
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPQPQPPPPPpprpqpPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSRE 2987

                         250
                  ....*....|...
gi 966980026  278 APATNGPPTTDSA 290
Cdd:PHA03247 2988 APASSTPPLTGHS 3000
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 672-717 1.65e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.16  E-value: 1.65e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 966980026  672 PRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLP 717
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
822-870 6.30e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 6.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 966980026   822 KIYATGGIVSSEgpALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIKK 870
Cdd:smart00612   1 KIYVVGGFDGGQ--RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 51-275 3.06e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   51 PGLLPLPVVPSRLPTP-ATAPAPCTTGSSEAITSLVASsasavtTKAPGISKADSQSQGLATSIRWGQTPINQSTPW--- 126
Cdd:pfam03154 277 PMPHSLQTGPSHMQHPvPPQPFPLTPQSSQSQVPPGPS------PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPapl 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  127 ---DTDEPPSKQMRESDNPG--------TGPWVTTVAAGNQP--------TLIAHSYGVAQPPTFS--------PAVNVQ 179
Cdd:pfam03154 351 smpHIKPPPTTPIPQLPNPQshkhpphlSGPSPFQMNSNLPPppalkplsSLSTHHPPSAHPPPLQlmpqsqqlPPPPAQ 430

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  180 APVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPGVGQVARPGPTAVGNghmag 259
Cdd:pfam03154 431 PPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP----- 505

                         250
                  ....*....|....*.
gi 966980026  260 pllpppPPAQPSATLP 275
Cdd:pfam03154 506 ------VPAAVSCPLP 515
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
22-193 9.03e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 42.82  E-value: 9.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  22 SVNGTHGTTSICSVTSGAGGGTASSLSARPGLLPLPVVPSRLPTPATAPAPCTTGSSEAITSLVASSAS-----AVTTKA 96
Cdd:COG3469   38 TATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANtgtstVTTTST 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  97 PGISKADSQSQGLATSIRWGQTPINQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQ--PTLIAHSYGVAQPPTFSP 174
Cdd:COG3469  118 GAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTtpSATTTATATTASGATTPS 197

                        170
                 ....*....|....*....
gi 966980026 175 AVNVQAPVIGVTPSLPPHV 193
Cdd:COG3469  198 ATTTATTTGPPTPGLPKHV 216
 
Name Accession Description Interval E-value
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 312-438 2.25e-83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 262.99  E-value: 2.25e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 312 PREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGqgGREKLELVLSNLQADVLELLLEF 391
Cdd:cd18258    1 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSG--GGEKLELTMSNINADVLELLLEF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966980026 392 VYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18258   79 VYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 432-533 2.02e-62

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 205.34  E-value: 2.02e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 432 TASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPAT 511
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|..
gi 966980026 512 RTQYAAELLAVVRLPFIHPSYL 533
Cdd:cd18468   81 RKQHIAELLAVVRLPFIHPSYL 102
PHA03098 PHA03098
kelch-like protein; Provisional
 333-860 1.50e-46

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 174.96  E-value: 1.50e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 333 IVVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqggreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAAS 412
Cdd:PHA03098  16 IVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---------NEINLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIAN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 413 KFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTK 492
Cdd:PHA03098  87 YLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 493 AEELVYETVIKWIKKDPATRTQYAAELLAVVRlpfihPSYLlnvvdNEELIKSSEACRdLVNEAKRYhmlPHARQEMQTP 572
Cdd:PHA03098 167 SEDVVLEIIIKWLTSKKNNKYKDICLILKVLR-----ITFL-----SEEGIKKLKRWK-LRIKKKKI---VFNKRCIKII 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 573 RTRPRLSAGVAEVIVLVGG-RQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFydREFFSVVSAGDNIYLSGGM-ESGVTL 650
Cdd:PHA03098 233 YSKKYNLNKILPRSSTFGSiIYIHITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMnKNNLSV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 651 ADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-----AYARATTI--YDPEKGNIKA 803
Cdd:PHA03098 391 LIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidNIKVYNIVesYNPVTNKWTE 470

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966980026 804 GPNMNHSRQFCSAVVLDGKIYATGGIvsSEGPALGNMEAYEPTTNTWTLLpHMPCPV 860
Cdd:PHA03098 471 LSSLNFPRINASLCIFNNKIYVVGGD--KYEYYINEIEVYDDKTNTWTLF-CKFPKV 524
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
615-872 3.56e-44

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 161.09  E-value: 3.56e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 615 WYPLASLPFyDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRcRHNS--LVYDGKIYTLGGLG 692
Cdd:COG3055    3 WSSLPDLPT-PRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPP-RHHAaaVAQDGKLYVFGGFT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 693 VAGN----VDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVlQSYVPQTNTWSFIES-PMID 767
Cdd:COG3055   81 GANPsstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWV-EVYDPATGTWTQLAPlPTPR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 768 NKYAPAVTLNGFVFILGGAYarattiYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGivssEGPALGNMEAYEPTT 847
Cdd:COG3055  160 DHLAAAVLPDGKILVIGGRN------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG----ESGFSDEVEAYDPAT 229

                        250       260
                 ....*....|....*....|....*
gi 966980026 848 NTWTLLPHMPCPVFRHGCVVIKKYI 872
Cdd:COG3055  230 NTWTALGELPTPRHGHAAVLTDGKV 254
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
571-831 2.34e-43

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 158.78  E-value: 2.34e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 571 TPRTRPRLSAGVAE-VIVLVGGRQMVGMTQRSLVAVT---CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGM-- 644
Cdd:COG3055    2 TWSSLPDLPTPRSEaAAALLDGKVYVAGGLSGGSASNsfeVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFtg 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 645 --ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAV-H 721
Cdd:COG3055   82 anPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 722 SAAATVCGGKIYVFGGVNEAGraagvlqsyvpQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTI--YDPEKG 799
Cdd:COG3055  162 LAAAVLPDGKILVIGGRNGSG-----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVeaYDPATN 230

                        250       260       270
                 ....*....|....*....|....*....|..
gi 966980026 800 NIKAGPNMNHSRQFCSAVVLDGKIYATGGIVS 831
Cdd:COG3055  231 TWTALGELPTPRHGHAAVLTDGKVYVIGGETK 262
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 431-566 1.93e-40

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 145.23  E-value: 1.93e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966980026 511 TRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHAR 566
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 436-537 1.38e-38

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 138.83  E-value: 1.38e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  436 CLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQY 515
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 966980026  516 AAELLAVVRLPFIHPSYLLNVV 537
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 431-560 3.03e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 124.41  E-value: 3.03e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 966980026 511 TRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYH 560
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 436-536 5.65e-32

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 119.75  E-value: 5.65e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   436 CLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQY 515
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 966980026   516 AAELLAVVRLPFIHPSYLLNV 536
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 434-544 4.14e-31

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 117.72  E-value: 4.14e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 434 SNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRT 513
Cdd:cd18445    4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 966980026 514 QYAAELLAVVRLPFIHPSYLLNVVDNEELIK 544
Cdd:cd18445   84 EHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 431-560 1.34e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 114.36  E-value: 1.34e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 966980026 511 TRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYH 560
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 308-436 1.76e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 110.63  E-value: 1.76e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggrEKLELvlSNLQADVLEL 387
Cdd:cd18250    1 DPAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRA---DRVVL--HGVSAEILGL 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966980026 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18250   76 LLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-438 5.19e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 106.78  E-value: 5.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREklelvLSNLQADVLELL 388
Cdd:cd18265    4 PCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVE-----IQKVSAAAMEVL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18265   79 LDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 435-537 7.37e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 105.47  E-value: 7.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQ 514
Cdd:cd18457    5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREE 84

                         90       100
                 ....*....|....*....|...
gi 966980026 515 YAAELLAVVRLPFIHPSYLLNVV 537
Cdd:cd18457   85 YLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 295-438 4.21e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 104.53  E-value: 4.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 295 MLRTIGvgKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREkle 374
Cdd:cd18259    1 MVRNID--DLDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVE--- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966980026 375 lvLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18259   76 --IKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-438 6.71e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 103.55  E-value: 6.71e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdsgQGGREKLELVLS---NLQADVL 385
Cdd:cd18254    3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFS-------NGLRESLDSTVNfhdSLHPEVL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966980026 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18254   76 ELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-436 1.52e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 102.22  E-value: 1.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggREKLeLVLSNLQADVLELLLE 390
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRES----REML-VEINGILAEAMDCFLQ 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18253   76 YVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-438 3.47e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 101.33  E-value: 3.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdSGQGGREKLELVLSNLQADVLELLLE 390
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFA-----GGMSESSKDVVQIHGVEPDIFHILLD 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18256   78 FIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 319-436 6.24e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 100.48  E-value: 6.24e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLV 398
Cdd:cd18240    8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALF-----TNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVP 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 966980026 399 IDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18240   83 ITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-438 6.58e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 100.64  E-value: 6.58e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggrEKLELVLSNLQADVLELLLE 390
Cdd:cd18237    4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTES-----KSSEVELKDAEPDIIELLVE 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18237   79 FAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 310-436 1.23e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 99.82  E-value: 1.23e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 310 GHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGqggreKLELVLSNLQADVLELLL 389
Cdd:cd18242    3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKG-----KSEVELQGLTASTMEILL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966980026 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18242   78 DFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 319-431 3.00e-24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 98.10  E-value: 3.00e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggrEKLELVLSNLQADVLELLLEFVYTGSLv 398
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESES-----SVSEITLDDVSPEDFEALLEFMYTGKL- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 966980026  399 IDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:pfam00651  75 ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 431-530 4.10e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 97.50  E-value: 4.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLnTKAEELVYETVIKWIKKDPA 510
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90       100
                 ....*....|....*....|
gi 966980026 511 TRTQYAAELLAVVRLPFIHP 530
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYVHP 99
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 328-414 1.06e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 95.31  E-value: 1.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSS-----EIELDDVSPEAFEALLDYIYTGELELSEENVEEL 75


                 ....*..
gi 966980026 408 LEAASKF 414
Cdd:cd18186   76 LAAADKL 82
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 430-526 1.59e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 95.45  E-value: 1.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 966980026 510 ATRTQYAAELLAVVRLP 526
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 306-439 1.71e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 96.78  E-value: 1.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggrEKLELVlsNLQADVL 385
Cdd:cd18268    1 FKDQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQ---AKVDLK--GIDSDVL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966980026 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18268   76 DQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
571-745 3.97e-23

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 100.23  E-value: 3.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 571 TPRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVavtcWNPQNNKWYPLASLPFyDREFFSVVSAGDN-IYLSGGMES 646
Cdd:COG3055  106 APMPTPRGGATALLLdgkIYVVGGWDDGGNVAWVEV----YDPATGTWTQLAPLPT-PRDHLAAAVLPDGkILVIGGRNG 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 647 GVTLadvwcymsllDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGvaGNVDHVERYDTITNQWEAVAPLPKAVHSAAAT 726
Cdd:COG3055  181 SGFS----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248

                        170
                 ....*....|....*....
gi 966980026 727 VCGGKIYVFGGVNEAGRAA 745
Cdd:COG3055  249 LTDGKVYVIGGETKPGVRT 267
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 306-438 5.10e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 95.21  E-value: 5.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggrekLELVLSNLQADVL 385
Cdd:cd18249    1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQ-----TEVTIRDIDERAM 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966980026 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18249   76 ELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 304-439 9.22e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 95.06  E-value: 9.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 304 YEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgQGGREKLElvlSNLQAD 383
Cdd:cd18267   16 YLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKES-QDSEVNFH---DSIHPE 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966980026 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18267   92 VLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 430-533 1.70e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 92.78  E-value: 1.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18444    1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                         90       100
                 ....*....|....*....|....
gi 966980026 510 ATRTQYAAELLAVVRLPFIHPSYL 533
Cdd:cd18444   81 PERKKHLAKLLALIRLPLLTPQFL 104
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-439 2.78e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 93.09  E-value: 2.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggrekLELVLSNLQADVLELLLE 390
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESI-----LTVKLDGLDPDAVEVLVN 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18306   76 YAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 430-520 1.95e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 89.28  E-value: 1.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18458    1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                         90
                 ....*....|.
gi 966980026 510 ATRTQYAAELL 520
Cdd:cd18458   81 ENRRQYLEALL 91
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 305-440 8.43e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 89.50  E-value: 8.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 305 EFTDPGHPREMLKELNQQRRAKAFTDLKIVVE--------GREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELV 376
Cdd:cd18273    3 ELEDAAHARALLAQLKSFYDARLLTDVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGGLYESKQE-----TVT 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966980026 377 LSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVL 440
Cdd:cd18273   78 IHDVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 330-431 1.13e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 87.36  E-value: 1.13e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   330 DLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLE 409
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFS-----SDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLE 75

                           90       100
                   ....*....|....*....|..
gi 966980026   410 AASKFQFHTFCKVCVSFLEKQL 431
Cdd:smart00225  76 LADYLQIPGLVELCEEFLLKLL 97
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 432-508 2.05e-20

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 85.92  E-value: 2.05e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966980026 432 TASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKD 508
Cdd:cd18508    1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 328-439 2.19e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 87.97  E-value: 2.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18340   27 FVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKR-----EIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDI 101

                         90       100       110
                 ....*....|....*....|....*....|..
gi 966980026 408 LEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18340  102 FAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-428 2.32e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 87.23  E-value: 2.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREklelvLSNLQADVLELL 388
Cdd:cd18198    6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYE-----IDFVSPEALTAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18198   81 LEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-427 2.62e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 87.19  E-value: 2.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELvlsnLQADVLELLLE 390
Cdd:cd18329    4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDV----FSPDTFTIILD 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18329   80 FVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-427 4.09e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 86.32  E-value: 4.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVlsnlQADVLELLLE 390
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVF----SSDAFSIILD 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18199   77 FVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 430-507 7.48e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 84.37  E-value: 7.48e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966980026 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKK 507
Cdd:cd18463    1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 316-439 8.99e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 86.31  E-value: 8.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 316 LKELNQQRRakaFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggrEKLELVLSNLQADVLELLLEFVYTG 395
Cdd:cd18269   18 LKDLLDENK---FVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEES-----KKKEVVLEDVDPDVMGMILKYLYTS 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 966980026 396 SLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18269   90 EIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-433 1.02e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 85.67  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqggREKLELVLSNLQADVLELLLE 390
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSE-----KENSEVEFQCIDETALQAIVE 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTA 433
Cdd:cd18257   76 YAYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 431-509 1.31e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 83.81  E-value: 1.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQ-EEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-428 2.29e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 84.90  E-value: 2.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLI----QRSVQDSGQGGREKLELVLsnLQADV 384
Cdd:cd18327    6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFtgggGGSGDLGAGGGQDVCELDF--VGPEA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 966980026 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18327   84 LGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 308-438 3.13e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 84.49  E-value: 3.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 308 DPGHPREMLKELNQQRRAKAFTDLKIV-VEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqggREKLELVLSNLQADVLE 386
Cdd:cd18252    1 DSSHPADFLDAFRTFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKE-----KSNNVIKLSGIDHDILE 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966980026 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18252   76 ALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 434-528 3.73e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 83.10  E-value: 3.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 434 SNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRT 513
Cdd:cd18515    3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                         90
                 ....*....|....*
gi 966980026 514 QYAAELLAVVRLPFI 528
Cdd:cd18515   83 CYLSELLQTVRLALL 97
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 431-533 6.07e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 82.76  E-value: 6.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|...
gi 966980026 511 TRTQYAAELLAVVRLPFIHPSYL 533
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLL 104
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 314-438 1.39e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 82.34  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 314 EMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggreKLELV-LSNLQADVLELLLEFV 392
Cdd:cd18238    1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAES------KQDSItIKDIDEEAVELLVDFA 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 966980026 393 YTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18238   75 YTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 314-421 2.37e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 81.51  E-value: 2.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 314 EMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSnlqaDVLELLLEFVY 393
Cdd:cd18330    4 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTS----EAFSIILDFLY 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 966980026 394 TGSLVIDSANAKTLLEAASKFQFH---TFCK 421
Cdd:cd18330   80 SGKLDLCSENVIEVMSAASYLQMTdvvNFCK 110
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 431-528 2.99e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 80.76  E-value: 2.99e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*...
gi 966980026 511 TRTQYAAELLAVVRLPFI 528
Cdd:cd18467   81 ERQKYLAQLLHCVRLPLL 98
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-428 4.93e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 80.75  E-value: 4.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREklelvLSNLQADVLELL 388
Cdd:cd18326    6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYE-----IDFVSAEALTAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18326   81 LDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 431-530 5.60e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 79.77  E-value: 5.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18485    1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                         90       100
                 ....*....|....*....|
gi 966980026 511 TRTQYAAELLAVVRLPFIHP 530
Cdd:cd18485   81 SRVQHLVELLKQVRLELVSP 100
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 430-527 6.18e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 79.71  E-value: 6.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*...
gi 966980026 510 ATRTQYAAELLAVVRLPF 527
Cdd:cd18447   81 PNRQPYMVDILAKVRFPL 98
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 434-525 7.47e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 79.46  E-value: 7.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 434 SNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRT 513
Cdd:cd18464    3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                         90
                 ....*....|..
gi 966980026 514 QYAAELLAVVRL 525
Cdd:cd18464   83 EVLPELLRSVRL 94
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 431-528 8.01e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 79.46  E-value: 8.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*...
gi 966980026 511 TRTQYAAELLAVVRLPFI 528
Cdd:cd18460   81 HRQHFWPELLQHVRLPFV 98
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 430-533 1.15e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 79.34  E-value: 1.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....
gi 966980026 510 ATRTQYAAELLAVVRLPFIHPSYL 533
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-436 1.22e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 79.75  E-value: 1.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLE 390
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQD-----EIELKGVSAKGLKHILD 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18255   76 FAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 429-532 1.38e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 79.03  E-value: 1.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 429 KQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKD 508
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                         90       100
                 ....*....|....*....|....
gi 966980026 509 PATRTQYAAELLAVVRLPFIHPSY 532
Cdd:cd18469   81 PQARAAHLPELLSLVHLSLLTDQY 104
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 314-440 1.97e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 79.66  E-value: 1.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 314 EMLKELNQQrraKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggrekLELVLSNLQADVLELLLEFVY 393
Cdd:cd18270   15 EQLKFFYEQ---QLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQ-----THVHLRNVDAATLQIIITYAY 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966980026 394 TGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVL 440
Cdd:cd18270   87 TGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-434 3.25e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 78.56  E-value: 3.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVlsnlQADVLELL 388
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIV----TAQGFKAI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 434
Cdd:cd18230   78 IDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 431-528 3.53e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 77.73  E-value: 3.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90
                 ....*....|....*...
gi 966980026 511 TRTQYAAELLAVVRLPFI 528
Cdd:cd18456   81 GRRQHVPRLMKCVRLPLL 98
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 431-528 7.57e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 76.81  E-value: 7.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*...
gi 966980026 511 TRTQYAAELLAVVRLPFI 528
Cdd:cd18514   81 KRKDYLPELLRNVRLALL 98
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 430-528 7.76e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 76.70  E-value: 7.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90
                 ....*....|....*....
gi 966980026 510 ATRTQYAAELLAVVRLPFI 528
Cdd:cd18459   81 QERRPHLPQVLQHVRLPLL 99
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 306-438 8.51e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 77.58  E-value: 8.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVqdsgqggREKLE--LVLSNLQAD 383
Cdd:cd18236    2 FDDTGLSLVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDL-------KEKYEekIIIKGVDAE 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966980026 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18236   75 TMQILLDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-428 1.14e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 76.84  E-value: 1.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVqDSGQGGREKLELVlsnlQADVLELL 388
Cdd:cd18328    6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGT-LADQPYVYEIDFV----TPEALSAI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18328   81 LEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 310-431 1.19e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 77.03  E-value: 1.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 310 GHPREMLKELNQQRRAKAFTDLKIVVEGR----EFEVHQNVLASCSLYFKDLIQrsvqdSGQGGREKLELVLSNLQADVL 385
Cdd:cd18248    3 DHTKEAFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFT-----SGLRECGMEVVPIEGVHPCVM 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 966980026 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18248   78 SRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-426 1.20e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 76.34  E-value: 1.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFkdliqRSVQDSGQGGreklELVLSNLQADVLELLLE 390
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFF-----QSLYGDGTSG----SVVLPESFAEVFGLLLD 71

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSF 426
Cdd:cd18232   72 FFYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 316-439 1.29e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 77.19  E-value: 1.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 316 LKELNQQRRakaFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdSGQGGREKLELVLSNLQADVLELLLEFVYTG 395
Cdd:cd18341   18 LKELLDENK---FVDCTLKAGDKSLPCHRLILAACSPYFREYFL-----SEESEEKKKEVVLDNVDPNIMDMILKYLYSA 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 966980026 396 SLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18341   90 EIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-429 1.40e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 76.54  E-value: 1.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsVQDSgqggreklelvLSNLQAD----- 383
Cdd:cd18334    2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLV---LHDN-----------LINLDTDmvnpt 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 966980026 384 VLELLLEFVYTGSLVIDSA----NAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18334   68 VFRQILDFIYTGKLLTSDQpgeqNFNALLTAASYLQLHDLAALCRKKLKR 117
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 431-538 1.57e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 75.97  E-value: 1.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|....*...
gi 966980026 511 TRTQYAAELLAVVRLPFIHPSYLLNVVD 538
Cdd:cd18446   81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 430-533 1.80e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 75.72  E-value: 1.80e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|....
gi 966980026 510 ATRTQYAAELLAVVRLPFIHPSYL 533
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 308-439 2.25e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 76.18  E-value: 2.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 308 DPGHPREMLKELNQQRRAKAFTDlkIVVE---GREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADV 384
Cdd:cd18274    2 DPLHACSILQQLKAMYDEGQLTD--IVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQK-----EVRIVGVEAES 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966980026 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18274   75 MHLVLDYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 329-437 2.28e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 75.48  E-value: 2.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 329 TDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLL 408
Cdd:cd18234    2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEE-----EIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLL 76

                         90       100
                 ....*....|....*....|....*....
gi 966980026 409 EAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18234   77 ATACLLQLSEVVEACCGFLMKQLHPSNCL 105
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 431-524 2.66e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 75.26  E-value: 2.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....
gi 966980026 511 TRTQYAAELLAVVR 524
Cdd:cd18477   81 NRQKALPTVFESIR 94
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 431-524 3.17e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 74.81  E-value: 3.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                         90
                 ....*....|....
gi 966980026 511 TRTQYAAELLAVVR 524
Cdd:cd18517   81 NRVKSLGEIFDCIR 94
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-431 6.15e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 74.77  E-value: 6.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELL 388
Cdd:cd18235    2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRAN-----RVTLQDVDGKALLLL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18235   77 IDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQL 119
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-431 9.78e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 74.51  E-value: 9.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLI--QRSVQDSGQGGREKLELVLSNLQADVLELL 388
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgQASPRLVLVSPAGKCVLDLHHVTVTGFAPL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 310-437 2.36e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 73.33  E-value: 2.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 310 GHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLL 389
Cdd:cd18271    6 CHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDG-----SVTISNLSPKAVKAFL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 966980026 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18271   81 DYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-437 3.35e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 72.54  E-value: 3.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqggrEKLElvLSNLQADVLELLLE 390
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSL------QRVE--LNDISPLGLATVIT 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18260   73 YAYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-426 3.52e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 72.27  E-value: 3.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLI--QRSVqdsgqggrekLELVLSNlqADVLE 386
Cdd:cd18206    3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFvdQKDV----------VHLDISN--AAGLG 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966980026 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSF 426
Cdd:cd18206   71 QVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 431-525 3.76e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 71.71  E-value: 3.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18516    1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQE 80

                         90
                 ....*....|....*
gi 966980026 511 TRTQYAAELLAVVRL 525
Cdd:cd18516   81 ERTKALPVLLESIRF 95
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 431-525 4.19e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 71.63  E-value: 4.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|....*
gi 966980026 511 TRTQYAAELLAVVRL 525
Cdd:cd18479   81 SRSQYLSSVLSQIRI 95
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 308-431 4.22e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 72.45  E-value: 4.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggrEKLElvLSNLQADVLEL 387
Cdd:cd18339    1 NPAHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKA---KKIE--IKDVDGQTLSK 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 966980026 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18339   76 LIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 431-533 4.85e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 71.69  E-value: 4.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18462    1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                         90       100
                 ....*....|....*....|...
gi 966980026 511 TRTQYAAELLAVVRLPfIHPSYL 533
Cdd:cd18462   81 KRIECAYDLLSSIKLD-LDEIYL 102
PHA02790 PHA02790
Kelch-like protein; Provisional
 331-787 5.92e-15

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 78.55  E-value: 5.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 331 LKIVVE--GREFEVHQNVLASCSLYFKD-LIQRSVQDSGQGGREKLELVLSNLQADVLellleFVYTGSLVIDSANAKTL 407
Cdd:PHA02790  22 FKTIIEaiGGNIIVNSTILKKLSPYFRThLRQKYTKNKDPVTRVCLDLDIHSLTSIVI-----YSYTGKVYIDSHNVVNL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 408 LEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVaaQEEIlsISKDDFIAY---V 484
Cdd:PHA02790  97 LRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEL--EDDI--IDNFDYLSMkliL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 485 SNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNV---VDNEELIKsseaCRDLVNEAKRYHM 561
Cdd:PHA02790 173 ESDELNVPDEDYVVDFVIKWYMKRRNRLGNLLLLIKNVIRSNYLSPRGINNVkwiLDCTKIFH----CDKQPRKSYKYPF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 562 LPHARQEMQTPRT-RPRLSAGVAEVIVLVGGrQMVGMTQRSLVAVTCwnpQNNKWYPLASLPfYDREFFSVVSAGDNIYL 640
Cdd:PHA02790 249 IEYPMNMDQIIDIfHMCTSTHVGEVVYLIGG-WMNNEIHNNAIAVNY---ISNNWIPIPPMN-SPRLYASGVPANNKLYV 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 641 SGGMESGVTLaDVWCYMSllDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGlgvagnvdHVERyDTIT-------NQWEAV 713
Cdd:PHA02790 324 VGGLPNPTSV-ERWFHGD--AAWVNMPSLLKPRCNPAVASINNVIYVIGG--------HSET-DTTTeyllpnhDQWQFG 391

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966980026 714 APLPKAVHSAAATVCGGKIYVfggvneAGRAAgvlQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAY 787
Cdd:PHA02790 392 PSTYYPHYKSCALVFGRRLFL------VGRNA---EFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFY 456
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 308-431 9.58e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 71.26  E-value: 9.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggREKlELVLSNLQADVLEL 387
Cdd:cd18338    1 NPRHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSES----RAK-RVRIKEVDGWTLKM 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 966980026 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18338   76 LIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-429 1.00e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 70.97  E-value: 1.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLI-QRSVQDSGQggreklELVLSNLQADVLELLL 389
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFsSQEIWISSH------VLELPDLKAEVFAEIL 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966980026 390 EFVYTGSLVIDSANAKTLLEAASKfqfhtfcKVCVSFLEK 429
Cdd:cd18223   75 NFIYSSKVVVKRQETVTDLVAAGK-------KLGITFLEN 107
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-431 1.26e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 71.22  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKdLIQRSVQDSgqggREKLELVLSNLQADVLELL 388
Cdd:cd18325    4 PDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH-LFYRDQLDK----RDIVHLNSDIVTAPAFSLL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL-EKQL 431
Cdd:cd18325   79 LEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLkDKEL 122
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 315-428 1.42e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 70.45  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvQDSGQGGREKLElvLSNLQADVLELLLEFVYT 394
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYN-PPKDDGSTYKIE--LEGISVEVMEEILDYIYT 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 966980026 395 GSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18245   78 GQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 306-436 1.43e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 71.43  E-value: 1.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVV---EGREFEVHQNVLASCSLYFKDLIQRSVQDSgQGGREKLELVLSN--L 380
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFggaGGREFRAHRSVLAAATEYFTPLLSGQFSES-RSGRVEMRKWSSEpgP 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966980026 381 QADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18241   80 DPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-439 5.00e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 69.45  E-value: 5.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLE 390
Cdd:cd18276    4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQR-----EVVLHDITAESVSIILN 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18276   79 YMYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-429 5.10e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 69.10  E-value: 5.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsVQDSgqggreklelvLSNLQAD----- 383
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLV---LHDN-----------LIHLDQDmvspt 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 966980026 384 VLELLLEFVYTGSLvIDSA----NAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18216   67 VFQQILDFIYTGKL-LDSLfeepNLSEVLAAANYLQLPDLAALCRSKLKR 115
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 314-431 7.56e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 68.83  E-value: 7.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 314 EMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS-GQGGREKLELVlsnlQADVLELLLEFV 392
Cdd:cd18201    7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKEScDQTTVTHLDVV----AVQGFSVILDFM 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966980026 393 YTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18201   83 YSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 431-526 1.02e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 67.58  E-value: 1.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|....*..
gi 966980026 511 TRTQYAAELLA-VVRLP 526
Cdd:cd18483   81 KREMHLPEIFAkCIRMP 97
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-423 1.33e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 67.86  E-value: 1.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFkdliqRSV-QDSGQggrEKLELVLSNLQADVLELLL 389
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYF-----GAQyKDTED---NIVFLDQSQVSADGFQKLL 72

                         90       100       110
                 ....*....|....*....|....*....|....
gi 966980026 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18217   73 EFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 432-524 1.75e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 66.96  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 432 TASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPAT 511
Cdd:cd18455    1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80

                         90
                 ....*....|...
gi 966980026 512 RTQYAAELLAVVR 524
Cdd:cd18455   81 RKVHLKDLMSSCW 93
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 305-433 2.08e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 68.53  E-value: 2.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 305 EFtdPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYF----KDLIQRsvqdsgqggREKLELVLSNL 380
Cdd:cd18324    2 EF--PDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFhlfyKDQLDK---------RDIVHLNSDIV 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966980026 381 QADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTA 433
Cdd:cd18324   71 TAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATT 123
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 306-439 5.40e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 66.62  E-value: 5.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVL 385
Cdd:cd18337    1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQE-----EIKMEGVEPNAL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966980026 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18337   76 WALVQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-437 5.49e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 66.91  E-value: 5.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLE 390
Cdd:cd18261   11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEAD-----EVNLHGVTSLGLKQALD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18261   86 FAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 305-434 6.94e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 66.38  E-value: 6.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 305 EFtdPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKdLIQRSVQDSGQGGREKLELVlsnlQADV 384
Cdd:cd18194    2 EF--PEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRDRLDKRDLVRLNSDIV----TAPA 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 966980026 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 434
Cdd:cd18194   75 FGLLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKALAE 124
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 310-425 7.30e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 66.03  E-value: 7.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 310 GHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDL-IQRSVQDSGQGGREklelvLSNLQADVLELL 388
Cdd:cd18202    1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELfIEKGAVSSHEAVVD-----LSGFCKSSFLPL 75

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
Cdd:cd18202   76 LEFAYTSELTFDFCSMAEVAMLARHLFMNEVLEICES 112
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 304-437 7.37e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 66.45  E-value: 7.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 304 YEFTDpgHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggrEKLELVLSNLQAd 383
Cdd:cd18266    3 YRWAD--HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQ---KEVELVGASYIG- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966980026 384 vLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18266   77 -LKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYL 129
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 319-430 1.00e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 65.38  E-value: 1.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLEFVYTGSLV 398
Cdd:cd18247   10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQD-----EITMQGIEPSALEALINFAYSGRIA 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 966980026 399 IDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Cdd:cd18247   85 IDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-439 1.04e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 65.84  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLE 390
Cdd:cd18336    2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQE-----EIKMEGVDPDALKALVH 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18336   77 YAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-431 1.47e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 65.82  E-value: 1.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggrekLELVLSNLQADVLELLLE 390
Cdd:cd18246   22 HYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQ-----THVTLHDIDPQALEQLVQ 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18246   97 YAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 137
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-427 1.79e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 65.07  E-value: 1.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqGGREKLELVLSNLQADVLELL 388
Cdd:cd18196    2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGD---QTMNMIQLDSEVVTAEAFAAL 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18196   79 IDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 117
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 434-533 2.08e-12

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 64.04  E-value: 2.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 434 SNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRT 513
Cdd:cd18466    4 ANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRK 83

                         90       100
                 ....*....|....*....|
gi 966980026 514 QYAAELLAVVRLPFIHPSYL 533
Cdd:cd18466   84 KHVVEVLEPVRFPLLPPQRL 103
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-413 2.43e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 64.53  E-value: 2.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRS--------VQDSGQGGREKLELVLSNLQA 382
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPlplgaaavAAAPGATQSPERVLELPGVKA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 966980026 383 DVLELLLEFVYTGSLVIDSANAKTLLEAASK 413
Cdd:cd18195   81 GVFSDVLNFIYSSRVALPGSAAAKELGAAGK 111
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 310-425 2.52e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 64.47  E-value: 2.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 310 GHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvqdsgqGGREKLELVLSNLQADVLELLL 389
Cdd:cd18224    8 DHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLST------ELDVARTYVVDFITPANFEKVL 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 966980026 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
Cdd:cd18224   82 SFIYTSELFTDLINVGVIYEVAEKLGMEDLLKACHS 117
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 305-445 2.58e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 64.85  E-value: 2.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 305 EFtdPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFkdliQRSVQDSGqggrEKLELVLSNLQ--- 381
Cdd:cd18323    2 EF--PDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFF----HMFYKEQL----DKRDLVCINNEivt 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966980026 382 ADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCvsflEKQLTASnclgvlAMAEA 445
Cdd:cd18323   72 APAFSLLLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVC----KKRLQAR------ALAEA 125
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-429 4.86e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 63.77  E-value: 4.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsVQDSgqggreklelvLSNLQAD----- 383
Cdd:cd18333    2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLV---VHDN-----------LINLDHEmvspg 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 966980026 384 VLELLLEFVYTGSLV-IDSANAKTL---LEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18333   68 IFRLILDYIYTGRLSeGDPGSEQNLgavLAAASYLQIPDLVALCKKKLKR 117
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 304-427 5.94e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 63.43  E-value: 5.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 304 YEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFkdlIQRSVqdsgqgGREKLELVLS---NL 380
Cdd:cd18278    7 YVYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYF---LQALV------GQTENDLVVSlpeEV 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966980026 381 QADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18278   78 TARGFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 308-435 6.41e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 63.52  E-value: 6.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrSVQDsgqggrekleLVLSNLQADVLEL 387
Cdd:cd18243   12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF--SINN----------LVLQGCSSIGLRL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 966980026 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18243   80 VLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 328-435 7.05e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 63.06  E-value: 7.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqDSGQGGREKLELVLSNLQADVLELLLEFVYTG---SLVIDSANA 404
Cdd:cd18297   12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSML-----SSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGgveSLDVAQDDA 86

                         90       100       110
                 ....*....|....*....|....*....|.
gi 966980026 405 KTLLEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18297   87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-427 7.72e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 63.16  E-value: 7.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdSGQGGREKLELVLSNLQADVLELLLE 390
Cdd:cd18277   10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRI------VGQADAELNITLPEEVTVKGFEPLIQ 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18277   84 FAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 304-440 9.41e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 63.37  E-value: 9.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 304 YEFTDPGHPREMLKE-LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqgGREKLeLVLSNLQA 382
Cdd:cd18272    7 YTFTDRSHSSRVAQSiMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKE----ARNRV-IELKDVSE 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966980026 383 DVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVL 440
Cdd:cd18272   82 SVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQVM 139
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-428 1.06e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 62.22  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvqdSGQgGREKLELVLSNLQAdvLELLLE 390
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNS---SSQ-KNDVFHLDIKNVGG--IGQILD 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18233   75 FMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 328-423 1.07e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 61.98  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggrEKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18314    6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIES-----NLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDL 80

                         90
                 ....*....|....*.
gi 966980026 408 LEAASKFQFHTFCKVC 423
Cdd:cd18314   81 LMLASKYQVPDLEKLC 96
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 305-423 1.37e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 62.52  E-value: 1.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 305 EFtdPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKdLIQRsvqDSGQGGREKLELVLSNLQADV 384
Cdd:cd18956    2 EF--PEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYR---DRPAGGRDTVRLNGDIVTAPA 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966980026 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18956   76 FGRLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-415 1.38e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 61.94  E-value: 1.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFkdliQRSVQDSGQGGREKLELVlSNLqadVLELLLE 390
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFF----YKFFQDFTQEPLVEIEGV-SNM---AFRHLIE 72

                         90       100
                 ....*....|....*....|....*.
gi 966980026 391 FVYTGSLVI-DSANAKTLLEAASKFQ 415
Cdd:cd18221   73 FTYTAKLMVqGEEEANDVWKAAEYLQ 98
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 328-415 1.50e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 61.03  E-value: 1.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGqggrekLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEH------PVIILPDVPYSELKALLDFIYTGEVNVSQEQLESL 74


                 ....*...
gi 966980026 408 LEAASKFQ 415
Cdd:cd18315   75 LKLAELLQ 82
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 304-423 1.55e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 62.29  E-value: 1.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 304 YEFTDPGHPREMLKELNQQRRAKA-FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGreklELVLSNLQA 382
Cdd:cd18207    2 YTYQVSQHSADMLHNLNQQRKSGGrFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPR----ELEMHTISS 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966980026 383 DVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18207   78 KVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDIC 118
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 308-398 1.86e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 61.39  E-value: 1.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrSVqdSGQggreklELVLSNLQADVLEL 387
Cdd:cd18219    1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLF--SV--AGQ------VVELNFIRADIFAE 70

                         90
                 ....*....|.
gi 966980026 388 LLEFVYTGSLV 398
Cdd:cd18219   71 ILNYIYSSKIV 81
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-439 3.06e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 61.60  E-value: 3.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLE 390
Cdd:cd18335    2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQE-----EIKMEGIDPNALWDLVQ 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18335   77 FAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 434-512 3.24e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 60.03  E-value: 3.24e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966980026 434 SNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATR 512
Cdd:cd18480    4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 315-415 4.20e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 60.96  E-value: 4.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGRekleLVLSNLQADVLELLLEFVYT 394
Cdd:cd18293    2 AFLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVV----LELQGLKAHTLLKLVDFLYT 77

                         90       100
                 ....*....|....*....|.
gi 966980026 395 GSLVIDSANAKTLLEAASKFQ 415
Cdd:cd18293   78 SELEVSSEEAQDVLAAARRLQ 98
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 313-436 4.42e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 61.35  E-value: 4.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 313 REMLKELNQQRRAKAF-TDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLEF 391
Cdd:cd18264   12 GEAVLSQYQSLRAEGFlCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKAR-----VIHLPVVSAAGLQRVLDF 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966980026 392 VYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18264   87 IYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-423 4.66e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 60.82  E-value: 4.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggreklELVLSNLQADVLELLLE 390
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSS------VIEIDFLRSDIFEEVLN 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18204   75 YMYTAKISVKKEDVNLMMSSGQILGIRFLDKLC 107
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 313-427 6.04e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 60.34  E-value: 6.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 313 REMLKELNQQRrakaFTDLKIVV--EGREFEVHQNVLASCSLYFKDLIQrsvqDSGQGGREKLELVLSNLQADVLELLLE 390
Cdd:cd18294    3 ADMKSLINNPE----FSDVKFLVgpERQEIFAHKCILAARCEVFRAMFL----TGPQKESTQSPLVLSDIEPEVFRAVLE 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18294   75 FIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-428 6.61e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 60.26  E-value: 6.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdSGQGGREKLELVL-SNLQADVLELLL 389
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIF------SGRVGEGVSVLTLpSGLEARGFQLLL 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966980026 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18332   76 DFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-411 8.85e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 59.81  E-value: 8.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQR-RAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggreklELVLSNLQADVLELLL 389
Cdd:cd18226    4 YNKNLLKYLNDDRqKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTD--------AVTLDHVSYSVFQHLL 75

                         90       100
                 ....*....|....*....|..
gi 966980026 390 EFVYTGSLVIDSANAKTLLEAA 411
Cdd:cd18226   76 EFLYTSEFFVYENEIPLVLEAA 97
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 305-428 1.47e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 59.57  E-value: 1.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 305 EFtdPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliQRSVQDSGQggrekleLVLSN-LQAD 383
Cdd:cd18227    4 EF--PDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCD--QVLLKNSRR-------IVLPDvMNPR 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966980026 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18227   73 VFENILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 431-504 2.07e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 57.40  E-value: 2.07e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKW 504
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 306-436 3.02e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 58.66  E-value: 3.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGRE--FEVHQNVLASCSLYFKDLIQrsvqdSGQGGREKLELVLSNLQAD 383
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDetFPVHRAMMASASDYFKAMFT-----GGMKEQELMCIKLHGVSKI 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966980026 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18239   76 GLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-417 4.41e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 57.91  E-value: 4.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggrekleLVLSNLQ--ADVLE 386
Cdd:cd18192    2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQ-------LNLSNMKisAECFD 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 966980026 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFH 417
Cdd:cd18192   75 LILQFMYLGKIMTAPSDFEQLKVAMNYLQLY 105
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 332-414 4.69e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 56.52  E-value: 4.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 332 KIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAA 411
Cdd:cd01165    2 VLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQA-----EINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76


                 ...
gi 966980026 412 SKF 414
Cdd:cd01165   77 NFL 79
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-415 4.77e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 58.12  E-value: 4.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdSGQgGREKLELVlSNLQADVLELL 388
Cdd:cd18289   10 PNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLF------SGN-SKSAFELP-ATVPPACFQQI 81

                         90       100
                 ....*....|....*....|....*..
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQ 415
Cdd:cd18289   82 LSFCYTGKLTMAASEQLVVMYTAGFLQ 108
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 330-427 5.92e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 56.71  E-value: 5.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 330 DLKIVVEGREFEVHQNVLASCSLYFkdlIQRSVqdsgqgGREKLELVLsNLQADV----LELLLEFVYTGSLVIDSANAK 405
Cdd:cd18955    3 DVTIVVEDQRFRAHRAVLAACSDYF---LSRVV------GQTDGDLVI-TLPEEVtvkgFEPLLQFAYTAKLLLSKENVL 72

                         90       100
                 ....*....|....*....|..
gi 966980026 406 TLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18955   73 EVCRCAEFLGVHNIEKACFDFL 94
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 432-486 6.57e-10

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 55.36  E-value: 6.57e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966980026 432 TASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSN 486
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
PHA03247 PHA03247
large tegument protein UL36; Provisional
 49-290 7.84e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.03  E-value: 7.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   49 ARPGLLPLPVVPSRlPTPATAPApctTGSSEAITSLVASSASAVTTKAPgiSKADSQSQGLATSIRWGQTPINQsTPWDT 128
Cdd:PHA03247 2755 ARPARPPTTAGPPA-PAPPAAPA---AGPPRRLTRPAVASLSESRESLP--SPWDPADPPAAVLAPAAALPPAA-SPAGP 2827

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  129 DEPPSKQMRESDNPGTGPWVTTVAAGNQ--PTLIAHSYGVAQPPTFSPAVNVQAPVIGVT---PSLPPHVGPQLPLMPGH 203
Cdd:PHA03247 2828 LPPPTSAQPTAPPPPPGPPPPSLPLGGSvaPGGDVRRRPPSRSPAAKPAAPARPPVRRLArpaVSRSTESFALPPDQPER 2907

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  204 YSLPQPPSQPLSSVVVNMPAQALYASPQ------PLAVSTLPGVGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSG 277
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPQPQPPPPPpprpqpPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSRE 2987

                         250
                  ....*....|...
gi 966980026  278 APATNGPPTTDSA 290
Cdd:PHA03247 2988 APASSTPPLTGHS 3000
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 328-426 8.58e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 56.35  E-value: 8.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18307    1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLI--SSNDMKATDELSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDL 78

                         90
                 ....*....|....*....
gi 966980026 408 LEAASKFQFHTFCKVCVSF 426
Cdd:cd18307   79 LKGAKYFNIPRLKDHCVDF 97
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 672-717 1.65e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.16  E-value: 1.65e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 966980026  672 PRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLP 717
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-429 1.69e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 56.02  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsVQDSGQggrekleLVLSN-LQADVLELLL 389
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLL--LNDTNC-------LVLPSvIEAAAFENLL 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966980026 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18200   72 QLIYSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELLKE 111
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-428 3.32e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 55.82  E-value: 3.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvqdsgqggrEKLELVLSNLQ-ADVLEL 387
Cdd:cd18222    6 PDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLN---------EMSTVSISVIKnPTVFEQ 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966980026 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18222   77 LLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-415 3.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 55.43  E-value: 3.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggrekLELVLSnLQADVLELL 388
Cdd:cd18290    8 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAV-------VELPAA-VQPQSFQQI 79

                         90       100
                 ....*....|....*....|....*..
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQ 415
Cdd:cd18290   80 LSFCYTGRLSMNVGDQFLLMYTAGFLQ 106
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 316-437 3.88e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 55.20  E-value: 3.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 316 LKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLEFVYTG 395
Cdd:cd18263    1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQS-----VVQLPTIPAKDLRLLISFAYSG 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 966980026 396 SLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18263   76 ILHLSWENLFEATCTALQLQISGALALCLDFLQREISPARCL 117
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 329-435 4.31e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 55.18  E-value: 4.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 329 TDLKIVVEGREFEVHQNVLASCSLYFkdliqRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLL 408
Cdd:cd18352   14 SDVTFLVEGRRFYAHRIALLASSDAF-----RAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLL 88

                         90       100
                 ....*....|....*....|....*..
gi 966980026 409 EAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18352   89 RAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 328-435 4.47e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 55.40  E-value: 4.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggrEKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18343   21 FTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEES-----KKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNL 95

                         90       100
                 ....*....|....*....|....*...
gi 966980026 408 LEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18343   96 LAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 328-435 7.02e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 54.46  E-value: 7.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREklelvLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18279   18 FTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVE-----INDVDPEVFKEMMRFIYTGKAPNLDKMADDL 92

                         90       100
                 ....*....|....*....|....*...
gi 966980026 408 LEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18279   93 LAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-411 7.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 54.42  E-value: 7.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvQDSGQGGREKleLVLSNLQADVLELLLE 390
Cdd:cd18212    6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMF----ADEGEVGQSI--YMLEGMVAETFGALLE 79

                         90       100
                 ....*....|....*....|.
gi 966980026 391 FVYTGSLVIDSANAKTLLEAA 411
Cdd:cd18212   80 FIYTGCLQVGEKSLEQILATA 100
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 311-411 8.12e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 53.75  E-value: 8.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvqdsgQGGREKLELVLSNLQadvLELLLE 390
Cdd:cd18262    1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLGS-----NGPLPPLSLEVTPVG---WEAVLT 72

                         90       100
                 ....*....|....*....|.
gi 966980026 391 FVYTGSLVIDSANAKTLLEAA 411
Cdd:cd18262   73 FAYTGVLGRNPATVGDILVAA 93
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 305-428 8.32e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 54.26  E-value: 8.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 305 EFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliqrsvqDSGQGGREKLEL-VLSNlqAD 383
Cdd:cd18220    2 QFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRD-------HSALSTMSGLSIsVIKN--PN 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966980026 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18220   73 VFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 431-509 8.81e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 52.89  E-value: 8.81e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18474    1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-426 1.07e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 53.72  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdsGQGGREKLELVLSN-LQADVLELLL 389
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFT------DQLKNNVSVINLDPeIEPEGFRILL 75

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966980026 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSF 426
Cdd:cd18215   76 DFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 313-426 1.35e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 53.44  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 313 REMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLI-QRSVQDSGQggrEKLELVLSNLQADVLELLLEF 391
Cdd:cd18292    2 REFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLsNDWWSESKQ---SEIELVEDPECAAVFEKFLRY 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 966980026 392 VYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSF 426
Cdd:cd18292   79 LYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 330-440 2.05e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 53.81  E-value: 2.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 330 DLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqggREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLE 409
Cdd:cd18244   32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRE-----RDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQ 106

                         90       100       110
                 ....*....|....*....|....*....|.
gi 966980026 410 AASKFQFHTFCKVCVSFLEKQLTASNCLGVL 440
Cdd:cd18244  107 AAMYVQLTEVVKFCCSFLLAKICLDNCAEIM 137
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 316-430 2.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 53.00  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 316 LKELNQQRRAK---AFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQdsgqggREKLELVLSNLQADVLELLLEFV 392
Cdd:cd18231    1 MDRLNEQRLFQpdlCDVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQ------LQRVELSLEALTSQGLQQILNFI 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 966980026 393 YTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Cdd:cd18231   75 YTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQELIDSR 112
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 306-423 4.55e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 52.19  E-value: 4.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKD--LIQRSvqdsgqggrEKLELVLSNLQAD 383
Cdd:cd18203    3 FQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDqfLLNPS---------SELQVSLMHSSRV 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966980026 384 VLELLLEfVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18203   74 VADLLLS-CYTGALEFSVRDIVNYLTAASYLQMEHVVEKC 112
PRK14131 PRK14131
N-acetylneuraminate epimerase;
670-785 4.88e-08

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 56.18  E-value: 4.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 670 TVPRCRHNSLVYDGKIYTLGGLGVAGN------VDHVERYDTITNQWEAV---APLPKAVHSAAaTVCGGKIYVFGGVNE 740
Cdd:PRK14131  72 GGPREQAVAAFIDGKLYVFGGIGKTNSegspqvFDDVYKYDPKTNSWQKLdtrSPVGLAGHVAV-SLHNGKAYITGGVNK 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 741 A---------GRAAG-------------------------VLqSYVPQTNTWSFI-ESPMIDNKYAPAVTLNGFVFILGG 785
Cdd:PRK14131 151 NifdgyfedlAAAGKdktpkdkindayfdkkpedyffnkeVL-SYDPSTNQWKNAgESPFLGTAGSAVVIKGNKLWLING 229
Kelch smart00612
Kelch domain;
822-870 6.30e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 6.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 966980026   822 KIYATGGIVSSEgpALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIKK 870
Cdd:smart00612   1 KIYVVGGFDGGQ--RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 313-423 7.45e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 51.40  E-value: 7.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 313 REMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliqrsvqdsgqggreKLELVLSNLQ------ADVLE 386
Cdd:cd18229    3 KSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHD---------------KLLLGHSEIEvppvvpAQTVR 67

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966980026 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18229   68 QLVEFMYSGSLVVAQSEALQILTAASILQIKTVIDEC 104
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-409 8.06e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 51.41  E-value: 8.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggreKLELVLSNLQADVLELLLE 390
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENES------QSVFQLDFCEPDAFENVLN 74

                         90
                 ....*....|....*....
gi 966980026 391 FVYTGSLVIDSANAKTLLE 409
Cdd:cd18209   75 YIYSSSLFVEKSSLAAVQE 93
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-427 8.14e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 51.19  E-value: 8.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQdsgqggreklELVLSNLQADVLELLLE 390
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQ----------HYTLDFLSPKTFQQILE 70

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18205   71 YAYTATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 811-857 9.21e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 49.15  E-value: 9.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 966980026  811 RQFCSAVVLDGKIYATGGIVSSEgpALGNMEAYEPTTNTWTLLPHMP 857
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQ--SLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 326-437 1.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 51.39  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 326 KAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGReklELVLSNLQADVLELLLEFVYTG---SLVIDSA 402
Cdd:cd18350   22 KEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQGSK---TIEISDIKYHIFQMLMQYLYYGgteSMEIPIA 98

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 966980026 403 NAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18350   99 DVLELLSAASLFQLDALQRHCEILCSQTINLENAV 133
PRK14131 PRK14131
N-acetylneuraminate epimerase;
682-785 1.59e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 54.64  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 682 DGKIYTlgGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHS-AAATVCGGKIYVFGGVNEAGrAAGVLQ------SYVPQ 754
Cdd:PRK14131  38 NNTVYV--GLGSAGTSWYKLDLNAPSKGWTKIAAFPGGPREqAVAAFIDGKLYVFGGIGKTN-SEGSPQvfddvyKYDPK 114

                         90       100       110
                 ....*....|....*....|....*....|...
gi 966980026 755 TNTWSFI--ESPMIDNKYAPAVTLNGFVFILGG 785
Cdd:PRK14131 115 TNSWQKLdtRSPVGLAGHVAVSLHNGKAYITGG 147
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-427 1.65e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 50.63  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVqdsgqggreKLELVLSNLQADV----LE 386
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQL---------KCNLSVINLDPEInpegFN 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966980026 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18331   78 ILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 327-439 2.44e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 50.77  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 327 AFTDLKIVVE-GREFEVHQNVLASCSLYFKDLIQRSVQDSGqGGREKLEL--VL--SNLQADVLELLLEFVYTGSLvidS 401
Cdd:cd18310   17 FYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGA-NTKPKLELreLIpgGIVGYDAFMLVLSYLYSGRL---R 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 966980026 402 ANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18310   93 LVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQI 130
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 326-437 2.61e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 50.36  E-value: 2.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 326 KAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdSGQGGREKLELVLSNLQADVLELLLEFVYTG---SLVIDSA 402
Cdd:cd18351   22 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKALL------SNKPSAENTCIEISYVKYHIFQLVMQYLYCGgteSLLIKNN 95

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 966980026 403 NAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18351   96 EIMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 330-396 2.75e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 49.21  E-value: 2.75e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966980026 330 DLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLeLVLSNLQADVLELLLEFVYTGS 396
Cdd:cd18301   20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCDV-VHIEKVPPEIFEQLLQFIYTDT 85
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 328-416 3.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 49.93  E-value: 3.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQggrEKLELVLSNLQAdvLELLLEFVYTGSLV---IDSANA 404
Cdd:cd18287   22 YSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQ---SEIELKDTNAEA--FKALLKYIYTGRLTltdLKEDVL 96

                         90
                 ....*....|..
gi 966980026 405 KTLLEAASKFQF 416
Cdd:cd18287   97 LDVLGLAHQYGF 108
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 435-526 4.15e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 48.96  E-value: 4.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPAtRTQ 514
Cdd:cd18449    5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDD-RMQ 83

                         90
                 ....*....|..
gi 966980026 515 YAAELLAVVRLP 526
Cdd:cd18449   84 FAAKLMENIRFP 95
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 327-435 4.17e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 49.46  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 327 AFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREklelvLSNLQADVLELLLEFVYTGSLVIDSANAKT 406
Cdd:cd18345   17 AFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVE-----ITDVDHEVMREMLRFIYTGKAPNLDKMADD 91

                         90       100
                 ....*....|....*....|....*....
gi 966980026 407 LLEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18345   92 LLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 309-427 6.19e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 49.05  E-value: 6.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 309 PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdsgqgGREKLELVLSNLQADVLELL 388
Cdd:cd18225    4 PNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLD---------STDTISIDASVVSPEEFALL 74

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18225   75 LEMVYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLL 113
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 328-435 7.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 48.94  E-value: 7.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggrEKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18342   22 FTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEES-----KKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDL 96

                         90       100
                 ....*....|....*....|....*...
gi 966980026 408 LEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18342   97 LAAADKYALERLKVMCEDALCSNLSVEN 124
PHA03247 PHA03247
large tegument protein UL36; Provisional
 48-250 7.40e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 7.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   48 SARPGllPLPVVPSRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPgiskadsqsqglatsirwgQTPINQSTPWD 127
Cdd:PHA03247 2698 LADPP--PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP-------------------AGPATPGGPAR 2756

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  128 TDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQAPVIGVTPSLPPHVGPQLPLMPGHYSLP 207
Cdd:PHA03247 2757 PARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 966980026  208 QPPSQPlssvvvnmpaQALYASPQPLAVSTLPGvGQVARPGPT 250
Cdd:PHA03247 2837 TAPPPP----------PGPPPPSLPLGGSVAPG-GDVRRRPPS 2868
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-427 8.64e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 48.66  E-value: 8.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggrEKLELVLSNLQADVLELLLE 390
Cdd:cd18251    6 HSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREM-----QQTEVLIHGVSYNAMCKILD 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18251   81 FIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFL 117
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 328-431 9.64e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 48.45  E-value: 9.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18296   17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDV 96

                         90       100
                 ....*....|....*....|....
gi 966980026 408 LEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18296   97 LYVADMYLLPGLKRLCGTVLAQSL 120
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 312-431 1.09e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 48.70  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 312 PREMLKELNQQRRAKAFTDLKIVVE----GREFEVHQNVLASCSLYFKDLIQRSVQDSGQggreKLELVLSNLQADVLEL 387
Cdd:cd18211    9 PSNLLNEMHKLRLLGHLCDVTVQVEhqgsKEEFSAHKAVLAASSKYFKEVFLNEKISDGK----NTNVMLNEIYTADFAS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 966980026 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCvSFLEKQL 431
Cdd:cd18211   85 FLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC-FQLKKQM 127
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 431-528 1.13e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 47.60  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18465    1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80

                         90
                 ....*....|....*...
gi 966980026 511 TRTQyAAELLAVVRLPFI 528
Cdd:cd18465   81 RRAS-ASHVLCHIRFPLM 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
799-857 1.13e-06

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 51.31  E-value: 1.13e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966980026 799 GNIKAGPNMNHSRQFCSAVVLDGKIYATGGIvsSEGPALGNMEAYEPTTNTWTLLPHMP 857
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGL--SGGSASNSFEVYDPATNTWSELAPLP 57
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 315-429 1.37e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 48.14  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqggrekLElVLSNLQADVLELLLEFVYT 394
Cdd:cd18208   12 VLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD--------IE-IPSVVSVQSVQKLIDFMYS 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 966980026 395 GSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18208   83 GVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 315-435 1.51e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 47.58  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 315 MLKELNQQRRAKAFTDLKI-VVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqggrEKLELVLSNLQADVLELLLEFVY 393
Cdd:cd18311    1 FLQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVLEQTCEIV------DDTLIMPNELQADAVVPVINFMY 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 966980026 394 TGSLVIDSANAKTLLEAASKFQfhtfckvcVSFLEKQLTASN 435
Cdd:cd18311   75 TGQLEFEEKSYGKLLRTAKELN--------MTVLLKLLEAHR 108
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 66-247 1.69e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 52.01  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   66 PATAPAPCTTGSSEAiTSLVASSASAVTTKAPgISKADSQSQglATSIRWGQTPINQS-----TPWDTDEPPSKQMRESD 140
Cdd:PRK10263  315 PITEPVAVAAAATTA-TQSWAAPVEPVTQTPP-VASVDVPPA--QPTVAWQPVPGPQTgepviAPAPEGYPQQSQYAQPA 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  141 NPGTGPWVTTVAAgNQPTLIAHSYGVAQPPTFSPAVN--VQAPVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVV 218
Cdd:PRK10263  391 VQYNEPLQQPVQP-QQPYYAPAAEQPAQQPYYAPAPEqpAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQ 469

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 966980026  219 VNMPAQALYASPQ----PLAVSTLPGVGQV--ARP 247
Cdd:PRK10263  470 QPAAQEPLYQQPQpveqQPVVEPEPVVEETkpARP 504
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 315-427 1.88e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 47.53  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliqrsvqdsgqggreklELVLSNLQADVL--------- 385
Cdd:cd18210    8 LLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHD-----------------QVLLKNMSSISLpgvmdpgaf 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 966980026 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18210   71 ESVLASAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 311-423 2.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 46.86  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSlyfkdliQRSVQDSGQGGREKLELvLSNLQADVLELLLE 390
Cdd:cd18218    1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGAS-------QQLGRQLTNPNPGQWCL-GEGISPSTFKQLLD 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 966980026 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18218   73 FVYGESVEVQPGELRPLLEAARALEVESLEEAC 105
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 431-524 2.90e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 46.34  E-value: 2.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEIL-SISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18482    1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQLLAKEEELcELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                         90
                 ....*....|....*
gi 966980026 510 ATRTQYAAELLAVVR 524
Cdd:cd18482   81 KERAASAAEVLKCVR 95
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 330-427 5.42e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 46.12  E-value: 5.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 330 DLKIVVEGREFEVHQNVLASCSlYFKDLIQRSVQDSGQGgREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLE 409
Cdd:cd18305   17 DITICALGREWKLHKIYLCQSG-YFASMFSGSWKESKET-VINLEIPDDNITVEALNVVFGSLYRDEIEIKPSRVVSILA 94

                         90
                 ....*....|....*...
gi 966980026 410 AASKFQFHTFCKVCVSFL 427
Cdd:cd18305   95 AATLLQLDGLIQQCSEVM 112
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 312-435 6.31e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 46.49  E-value: 6.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 312 PREMLK-ELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREklelvLSNLQADVLELLLE 390
Cdd:cd18344    6 PRHMLTdDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIE-----IHDLDPQVFKEMMG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966980026 391 FVYTGSL--VIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18344   81 FIYTGKAphLHSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 431-525 6.76e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 45.25  E-value: 6.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDpA 510
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-Q 79

                         90
                 ....*....|....*
gi 966980026 511 TRTQYAAELLAVVRL 525
Cdd:cd18470   80 KRVKYAADLLSNIRF 94
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 312-416 7.00e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 45.67  E-value: 7.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 312 PREMLKElnqqrraKAFTDLKIVVEGRE-FEVHQNVLASCSLYFKDLIqrSVQdsgqggrekLELVLSNL-QADVLELLL 389
Cdd:cd18299    3 LRNLLHS-------PSCADVVFILQGGVrIFAHRIVLAAASSVFADLF--LMM---------TVVTLDSDiTPEAFRRVL 64

                         90       100
                 ....*....|....*....|....*..
gi 966980026 390 EFVYTGSLVIDSANAKTLLEAASKFQF 416
Cdd:cd18299   65 EFLYTGVLDENEDDLKELKDAAELLEL 91
PLN02153 PLN02153
epithiospecifier protein
 672-872 1.00e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 48.44  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 672 PRCRHNSLVYDGKIYTLGGLGVAGnvDHVER----YDTITNQWeAVAP----LPK-AVHSAAATVCGGKIYVFGGVNEAg 742
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGELKPN--EHIDKdlyvFDFNTHTW-SIAPangdVPRiSCLGVRMVAVGTKLYIFGGRDEK- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 743 RAAGVLQSYVPQTNTWSFIESpmIDNKYAP-AVTLNG------FVFILGGAyARATTIYDPEK------GNIKAG----- 804
Cdd:PLN02153  98 REFSDFYSYDTVKNEWTFLTK--LDEEGGPeARTFHSmasdenHVYVFGGV-SKGGLMKTPERfrtieaYNIADGkwvql 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 805 --PNMN-HSRQFCSAVVLDGKIYATGGIVSSEGPALGN------MEAYEPTTNTWTLLPHMPC-----PVFRHGcvVIKK 870
Cdd:PLN02153 175 pdPGENfEKRGGAGFAVVQGKIWVVYGFATSILPGGKSdyesnaVQFFDPASGKWTEVETTGAkpsarSVFAHA--VVGK 252


                 ..
gi 966980026 871 YI 872
Cdd:PLN02153 253 YI 254
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 330-440 1.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 44.79  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 330 DLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVqdsgqggrekleLVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLE 409
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDI------------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVA 73

                         90       100       110
                 ....*....|....*....|....*....|.
gi 966980026 410 AASKFQFHTFCKVCVSFLEKQLTASNCLGVL 440
Cdd:cd18275   74 GARFLQMPCAAQCAVDAVRAQLCLGNCYEVL 104
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 325-429 1.28e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 44.94  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 325 AKAF-----TDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVI 399
Cdd:cd18298    4 RKAFndprtSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQ-----SHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDL 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 966980026 400 DSANAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18298   79 PPEDAIGLLDLANSYCEERLKKLCEDIIKQ 108
Kelch smart00612
Kelch domain;
638-683 1.32e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.93  E-value: 1.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 966980026   638 IYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDG 683
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 326-436 1.55e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 45.01  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 326 KAFTDLKIVVEGREFEVHQNVLAScslyfkdliqRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGsLVIDSANAK 405
Cdd:cd18303   16 ELYSDITIKLADKSIPAHKFVLAA----------RSEKWSNENLASTNELDLSDISYEVVLALLRWLYTD-ELDLTLDDE 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 966980026 406 TLLE---AASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18303   85 FLLElmkAAKRFQLTDLVERCERALMSSVNVDNC 118
PHA03247 PHA03247
large tegument protein UL36; Provisional
 34-292 1.72e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   34 SVTSGAGGGTASSLSARP-------GLLPLPVVPSRLPTPATAPAPCTTGSSEAITSLVASSASAvttkAPGISKADSQS 106
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPrapvddrGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPT----VPPPERPRDDP 2656

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  107 QGLATSIRwgQTPINQSTPWDTDEPPSKQMRESDNPGTGPwVTTVA----AGNQPTLIAHSYGVAQPPTFSPAVNVQA-P 181
Cdd:PHA03247 2657 APGRVSRP--RRARRLGRAAQASSPPQRPRRRAARPTVGS-LTSLAdpppPPPTPEPAPHALVSATPLPPGPAAARQAsP 2733

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  182 VIGVTPSLPPH-VGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQA-LYASPQPLAVSTLPGVGQVARPGPTAVGNGHMAG 259
Cdd:PHA03247 2734 ALPAAPAPPAVpAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA 2813

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 966980026  260 PLLPPPPPAQPSATLP-------SGAPATNGPPTTDSAHG 292
Cdd:PHA03247 2814 PAAALPPAASPAGPLPpptsaqpTAPPPPPGPPPPSLPLG 2853
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 329-414 1.91e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 44.63  E-value: 1.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 329 TDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDsgqgGREKlELVLSNLQADVLELLLEFVYTGSL----------- 397
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMRE----ENEG-EIVIEDVEPPVFKALLHFIYKDELpddvepagsds 89

                         90
                 ....*....|....*...
gi 966980026 398 -VIDSANAKTLLEAASKF 414
Cdd:cd18280   90 sSLDTTMAQHLLAAADRY 107
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 431-518 2.02e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 43.80  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 966980026 511 TRTQYAAE 518
Cdd:cd18451   81 ERERYFEE 88
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 51-275 3.06e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   51 PGLLPLPVVPSRLPTP-ATAPAPCTTGSSEAITSLVASsasavtTKAPGISKADSQSQGLATSIRWGQTPINQSTPW--- 126
Cdd:pfam03154 277 PMPHSLQTGPSHMQHPvPPQPFPLTPQSSQSQVPPGPS------PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPapl 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  127 ---DTDEPPSKQMRESDNPG--------TGPWVTTVAAGNQP--------TLIAHSYGVAQPPTFS--------PAVNVQ 179
Cdd:pfam03154 351 smpHIKPPPTTPIPQLPNPQshkhpphlSGPSPFQMNSNLPPppalkplsSLSTHHPPSAHPPPLQlmpqsqqlPPPPAQ 430

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  180 APVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPGVGQVARPGPTAVGNghmag 259
Cdd:pfam03154 431 PPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP----- 505

                         250
                  ....*....|....*.
gi 966980026  260 pllpppPPAQPSATLP 275
Cdd:pfam03154 506 ------VPAAVSCPLP 515
Kelch_6 pfam13964
Kelch motif;
672-719 3.90e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.94  E-value: 3.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 966980026  672 PRCRHNSLVYDGKIYTLGGLGVAGN-VDHVERYDTITNQWEAVAPLPKA 719
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPaLNKLEVYNPLTKSWEELPPLPTP 49
Kelch smart00612
Kelch domain;
684-730 4.34e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 4.34e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 966980026   684 KIYTLGGLGvaGNVDH--VERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
Cdd:smart00612   1 KIYVVGGFD--GGQRLksVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 721-765 4.64e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.44  E-value: 4.64e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 966980026  721 HSAAATVCGGKIYVFGGVNEAGRAAGVlQSYVPQTNTWSFIESPM 765
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNSV-EVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 315-427 4.89e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 43.32  E-value: 4.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKD--LIQRSVQdsgqggrekleLVLSNLQ-ADVLELLLEF 391
Cdd:cd18197   12 VLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDqfLLNQSKQ-----------VRITILQsAEVGRKLLLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 966980026 392 VYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18197   81 CYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 315-414 6.11e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 43.06  E-value: 6.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRsvQDSgqggrEKLELVLSNLQADVLELLLEFVYT 394
Cdd:cd18193    8 LLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVH--QTS-----ECVRLKPTDIQPDIFSYLLHLMYT 80

                         90       100
                 ....*....|....*....|...
gi 966980026 395 GSL---VIDSANaktlLEAASKF 414
Cdd:cd18193   81 GKMapqLIDPVR----LEQGIKF 99
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 329-397 6.55e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 42.32  E-value: 6.55e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966980026 329 TDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvqdSGQGGREKLELVLSNLQADVLELLLEFVYTGSL 397
Cdd:cd18283    3 TDVDLVFQGTCFPVHRAILSARCPFFRDLLSSS---PGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEF 68
PHA02713 PHA02713
hypothetical protein; Provisional
 305-713 9.50e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 46.16  E-value: 9.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 305 EFTDPGHPREMLKELNQQRRAKAFTDLKIVV-EGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELvlsnLQAD 383
Cdd:PHA02713   2 DIDDIKHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQM----FDKD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 384 VLELLLEFVYTGSlvIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLamaeamqcSELYHMAKAFALQIF 463
Cdd:PHA02713  78 AVKNIVQYLYNRH--ISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMY--------HRLYEMSHIPIVKYI 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 464 PEVAAQEEILSISKDDFIAYVSN---DSLNTKAEELVYE------TVIKWIKKDPATRTQYAAeLLAVVRLPFIHPSYLL 534
Cdd:PHA02713 148 KRMLMSNIPTLITTDAFKKTVFEilfDIISTNDNVYLYRegykvtILLKWLEYNYITEEQLLC-ILSCIDIQNLDKKSRL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 535 NVVDNEELIKSSEACRDLVNEAKRYHMLPhaRQ-------------------------EMQTPRTRPR-----LSAGVAE 584
Cdd:PHA02713 227 LLYSNKTINMYPSCIQFLLDNKQNRNIIP--RQlclvchdtkynvcnpcilvynintmEYSVISTIPNhiinyASAIVDN 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 585 VIVLVGGRQMVgmtqrslvavtcwNPQNNKWYPL-------ASLP--FYDREFFSVVSAGDNIYLSGGMESGVTLADVWC 655
Cdd:PHA02713 305 EIIIAGGYNFN-------------NPSLNKVYKInienkihVELPpmIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIEC 371

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966980026 656 YMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG---------------LGVAGNV---DHVERYDTITNQWEAV 713
Cdd:PHA02713 372 YTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehidytsvhhmnsIDMEEDThssNKVIRYDTVNNIWETL 447
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 310-452 9.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 42.96  E-value: 9.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 310 GHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDL-IQRSvqdsgqggREKLELVLSNLQADVLELL 388
Cdd:cd18213    3 SHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIfIHQS--------SECIKIQPTDIQPDIFSYL 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966980026 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVcvsflekqltaSNCLGVLAMAEAMQCSELY 452
Cdd:cd18213   75 LHIMYTGKGPKQSVDHSRLEEGIRFLHANYLSRI-----------ATEMNQDFSPETMQSSNLY 127
Kelch_4 pfam13418
Galactose oxidase, central domain;
811-858 1.24e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 40.29  E-value: 1.24e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 966980026  811 RQFCSAVVL-DGKIYATGGIvSSEGPALGNMEAYEPTTNTWTLLPHMPC 858
Cdd:pfam13418   2 RAYHTSTSIpDDTIYLFGGE-GEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
PHA03378 PHA03378
EBNA-3B; Provisional
 57-315 1.92e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  57 PVVPSRLPTPATAPApcttgsseAITSLVASSASAVTTKAPGiskadsqsqglatsirWGQTPINQSTPWDTDEPPSKQM 136
Cdd:PHA03378 558 PVHDQLLPAPGLGPL--------QIQPLTSPTTSQLASSAPS----------------YAQTPWPVPHPSQTPEPPTTQS 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 137 RESDNPGTGPWVTTVAAgnqptlIAHSYGVAQPPTFSPAVnvqapviGVTPSLPPHVGPQlPLMPGHYSLPQPPSQPLSS 216
Cdd:PHA03378 614 HIPETSAPRQWPMPLRP------IPMRPLRMQPITFNVLV-------FPTPHQPPQVEIT-PYKPTWTQIGHIPYQPSPT 679

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 217 VVVNM-PAQALYASPQPLAVSTLPGVGQVARPGPTAVGNGhmAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQM 295
Cdd:PHA03378 680 GANTMlPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAA--ATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPP 757

                        250       260
                 ....*....|....*....|
gi 966980026 296 LRTIGVGKYEFTDPGHPREM 315
Cdd:PHA03378 758 AAAPGRARPPAAAPGAPTPQ 777
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 89-287 2.48e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   89 ASAVTTKAPGISKADSQSQGLATSIrwGQTPINQ---STPWDTDEP--------PSKQMRESDN---------------- 141
Cdd:pfam03154  97 ATAKKSKTQEISRPNSPSEGEGESS--DGRSVNDegsSDPKDIDQDnrstspsiPSPQDNESDSdssaqqqilqtqppvl 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  142 ---------PGTGPWVTTVAAGNQPTLIAHSYGV-AQPPTFSPAVNVQAPV-----IGVTPSLPPH--VGPQLPLMPghy 204
Cdd:pfam03154 175 qaqsgaaspPSPPPPGTTQAATAGPTPSAPSVPPqGSPATSQPPNQTQSTAaphtlIQQTPTLHPQrlPSPHPPLQP--- 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  205 sLPQPP------SQPLSSVVVNMPAQALYAS-------------PQPLAVSTLPGVGQVArPGPTAVGNGHMAGPLLP-P 264
Cdd:pfam03154 252 -MTQPPppsqvsPQPLPQPSLHGQMPPMPHSlqtgpshmqhpvpPQPFPLTPQSSQSQVP-PGPSPAAPGQSQQRIHTpP 329

                         250       260       270
                  ....*....|....*....|....*....|..
gi 966980026  265 PPPA---------QPSATLPSGAPATNGPPTT 287
Cdd:pfam03154 330 SQSQlqsqqppreQPLPPAPLSMPHIKPPPTT 361
Kelch_6 pfam13964
Kelch motif;
811-859 2.87e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.24  E-value: 2.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 966980026  811 RQFCSAVVLDGKIYATGGIVSSeGPALGNMEAYEPTTNTWTLLPHMPCP 859
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNA-SPALNKLEVYNPLTKSWEELPPLPTP 49
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 26-302 5.51e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.41  E-value: 5.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   26 THGT-TSICSVTSGAGGGTASSLSARPGLLPLPVVPSRLPTPATAP--------------APCTTGSSEAITSLVASSAS 90
Cdd:pfam17823  92 PHGTdLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALpseafsapraaacrANASAAPRAAIAAASAPHAA 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   91 AVTTKAPGISKADSQSQGLATSIRWGQT-----------PINQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQP-- 157
Cdd:pfam17823 172 SPAPRTAASSTTAASSTTAASSAPTTAAssapatltparGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTpa 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  158 ---TLIAHSYGVAqppTFSPAVNVQAPViGVTPSLPPHvgpqlplMPGHYSL--PQPPSQP-----LSSVVVNMPAQALY 227
Cdd:pfam17823 252 alaTLAAAAGTVA---SAAGTINMGDPH-ARRLSPAKH-------MPSDTMArnPAAPMGAqaqgpIIQVSTDQPVHNTA 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  228 ASPQPlavstLPGVGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGP------PTTDSAHGLQMLRTIGV 301
Cdd:pfam17823 321 GEPTP-----SPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPeveatsPTTQPSPLLPTQGAAGP 395


                  .
gi 966980026  302 G 302
Cdd:pfam17823 396 G 396
PHA03247 PHA03247
large tegument protein UL36; Provisional
 54-290 5.91e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 5.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   54 LPLPVVPSR-LPTPATAPAPcttgSSEAITSLVA---SSASAVTTKAPGISKADSQSQGLATSIRWGQTPIN------QS 123
Cdd:PHA03247 2558 AAPPAAPDRsVPPPRPAPRP----SEPAVTSRARrpdAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDppppspSP 2633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  124 TPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQAPVIGVTPSLPPHVGPQLPLMPGH 203
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPH 2713

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  204 YSLPQPPSQPL-SSVVVNMPAQALYASPQPLAVSTLPGVGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATN 282
Cdd:PHA03247 2714 ALVSATPLPPGpAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSE 2793


                  ....*...
gi 966980026  283 GPPTTDSA 290
Cdd:PHA03247 2794 SRESLPSP 2801
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 431-507 6.10e-04

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 39.91  E-value: 6.10e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966980026 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSIS--KDDFIaYVSNDSLNTKAEELVYETVIKWIKK 507
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPrlQIEVI-LESNQELESINERKLCQLVLEWVQR 78
PHA03378 PHA03378
EBNA-3B; Provisional
 15-374 6.25e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 6.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  15 GWDRREWSVngTHGTTSicsvtsgAGGGTASSL---SARPGLLPLPVVPSRLPTPATAPAP--CTTGSSEAITSLVASSA 89
Cdd:PHA03378 591 SYAQTPWPV--PHPSQT-------PEPPTTQSHipeTSAPRQWPMPLRPIPMRPLRMQPITfnVLVFPTPHQPPQVEITP 661

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  90 SAVTTKAPGISKADSQSQGLATSIR--WG----QTPINQSTPWDTDE-PPSKQMRESDNPGTGPWVTTVAAGNQPTLIA- 161
Cdd:PHA03378 662 YKPTWTQIGHIPYQPSPTGANTMLPiqWApgtmQPPPRAPTPMRPPAaPPGRAQRPAAATGRARPPAAAPGRARPPAAAp 741

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 162 -------HSYGVAQPPTFSP--AVNVQAPVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQ-PLSSVVVNMPAQALYASP- 230
Cdd:PHA03378 742 grarppaAAPGRARPPAAAPgrARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQaGPTSMQLMPRAAPGQQGPt 821

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 231 QPLAVSTLPGVGQVARPG---PTAVGNGHMAGPLLPPPPPAQ----------PSATLPSGAPATNGPPTTDSAHGLQMLR 297
Cdd:PHA03378 822 KQILRQLLTGGVKRGRPSlkkPAALERQAAAGPTPSPGSGTSdkivqapvfyPPVLQPIQVMRQLGSVRAAAASTVTQAP 901

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966980026 298 TIGVGKYEFTDPGHPREMLKelNQQRRAKAFTDLKIvvegrefeVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLE 374
Cdd:PHA03378 902 TEYTGERRGVGPMHPTDIPP--SKRAKTDAYVESQP--------PHGGQSHSFSVIWENVSQGQQQTLECGGTTKQE 968
Kelch_6 pfam13964
Kelch motif;
721-767 7.03e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 7.03e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 966980026  721 HSAAAtvCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMID 767
Cdd:pfam13964   5 HSVVS--VGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49
PLN02193 PLN02193
nitrile-specifier protein
 631-788 8.27e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.02  E-value: 8.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 631 VVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNL---VSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTIT 707
Cdd:PLN02193 224 MVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLltpVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVD 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 708 NQW-EAVAPLPK--AVHSAAATVCGGKIYVFGGVNeaGRAAGVLQSYVPQTNTWSFIES----PMIDNKYAPAVtLNGFV 780
Cdd:PLN02193 304 KKWfHCSTPGDSfsIRGGAGLEVVQGKVWVVYGFN--GCEVDDVHYYDPVQDKWTQVETfgvrPSERSVFASAA-VGKHI 380


                 ....*...
gi 966980026 781 FILGGAYA 788
Cdd:PLN02193 381 VIFGGEIA 388
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
22-193 9.03e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 42.82  E-value: 9.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  22 SVNGTHGTTSICSVTSGAGGGTASSLSARPGLLPLPVVPSRLPTPATAPAPCTTGSSEAITSLVASSAS-----AVTTKA 96
Cdd:COG3469   38 TATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANtgtstVTTTST 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  97 PGISKADSQSQGLATSIRWGQTPINQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQ--PTLIAHSYGVAQPPTFSP 174
Cdd:COG3469  118 GAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTtpSATTTATATTASGATTPS 197

                        170
                 ....*....|....*....
gi 966980026 175 AVNVQAPVIGVTPSLPPHV 193
Cdd:COG3469  198 ATTTATTTGPPTPGLPKHV 216
Kelch_4 pfam13418
Galactose oxidase, central domain;
672-717 1.00e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 1.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 966980026  672 PRCRHnSLVY--DGKIYTLGGLGVAGNV-DHVERYDTITNQWEAVAPLP 717
Cdd:pfam13418   1 PRAYH-TSTSipDDTIYLFGGEGEDGTLlSDLWVFDLSTNEWTRLGSLP 48
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 25-290 1.11e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 42.64  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   25 GTHGTTSICSVTSGAGGGTASSLSARPGLLPLP--VVPSRlPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKA 102
Cdd:pfam17823 171 ASPAPRTAASSTTAASSTTAASSAPTTAASSAPatLTPAR-GISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVT 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  103 DSQSQGLATSIRWGQT---PINQSTPWDTDEPPSKQMrESDNPGTGPwvttvaagnqptlIAHSYGVAQPPTFSpaVNVQ 179
Cdd:pfam17823 250 PAALATLAAAAGTVASaagTINMGDPHARRLSPAKHM-PSDTMARNP-------------AAPMGAQAQGPIIQ--VSTD 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  180 APVIGVTPSlPPHVGPQLPLMPghySLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPGVGQVARPGPTAvgnghmag 259
Cdd:pfam17823 314 QPVHNTAGE-PTPSPSNTTLEP---NTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEVEATSPTT-------- 381

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 966980026  260 pllpppppaQPSATLPS---GAP---------ATNGPPTTDSA 290
Cdd:pfam17823 382 ---------QPSPLLPTqgaAGPgillapeqvATEATAGTASA 415
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 672-716 1.30e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 37.32  E-value: 1.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 966980026  672 PRCRHNSLVYDGKIYTLGGLGVAGN--VDHVERYDTITNQWEAVAPL 716
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDlsSSDVLVYDPETNVWTEVPRL 47
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 315-429 1.34e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 39.42  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliQRSVQDSGqggreklELVLSNLQ-ADVLELLLEFVY 393
Cdd:cd18214   12 MLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRD--QFLLNDSR-------EVQISILQnSEVGRQLLLSCY 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 966980026 394 TGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18214   83 TGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWK 118
PLN02153 PLN02153
epithiospecifier protein
 631-785 1.72e-03

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 41.51  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 631 VVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTV---PRCR--HNSLVYDGKIYTLGGLGVAGNVDHVERYDT 705
Cdd:PLN02153  81 MVAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEeggPEARtfHSMASDENHVYVFGGVSKGGLMKTPERFRT 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 706 IT------NQWeAVAPLP----KAVHSAAATVCGGKIYVFGGVNEAGRAAG-------VLQSYVPQTNTWSFIES----P 764
Cdd:PLN02153 161 IEayniadGKW-VQLPDPgenfEKRGGAGFAVVQGKIWVVYGFATSILPGGksdyesnAVQFFDPASGKWTEVETtgakP 239

                        170       180
                 ....*....|....*....|.
gi 966980026 765 MIDNKYAPAVtLNGFVFILGG 785
Cdd:PLN02153 240 SARSVFAHAV-VGKYIIIFGG 259
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 435-506 2.12e-03

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 37.71  E-value: 2.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966980026 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIK 506
Cdd:cd18503    5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTE 76
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 27-285 2.16e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026   27 HGTTSICSvTSGAGGGTASSLSARPGLlplPVVPSRlPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPgisKADSQS 106
Cdd:pfam03154 178 SGAASPPS-PPPPGTTQAATAGPTPSA---PSVPPQ-GSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLP---SPHPPL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  107 QGLATSIRWGQTPInQSTPWDTDEPPSKQMRESDNpgTGPWVTTVAAGNQPTLIAHSYGVAQ-PPTFSPAVNVQAPVigv 185
Cdd:pfam03154 250 QPMTQPPPPSQVSP-QPLPQPSLHGQMPPMPHSLQ--TGPSHMQHPVPPQPFPLTPQSSQSQvPPGPSPAAPGQSQQ--- 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  186 TPSLPPhvgPQLPLMPghyslPQPP-SQPLSSVVVNMPaqalYASPQPLA-VSTLPGVGQVARPGPTAVGNGHMAGPLLP 263
Cdd:pfam03154 324 RIHTPP---SQSQLQS-----QQPPrEQPLPPAPLSMP----HIKPPPTTpIPQLPNPQSHKHPPHLSGPSPFQMNSNLP 391

                         250       260
                  ....*....|....*....|..
gi 966980026  264 PPPPAQPSATLPSGAPATNGPP 285
Cdd:pfam03154 392 PPPALKPLSSLSTHHPPSAHPP 413
Kelch_3 pfam13415
Galactose oxidase, central domain;
682-727 2.70e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.50  E-value: 2.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 966980026  682 DGKIYTLGGLGVAGN--VDHVERYDTITNQWEAVAPLPKAVHSAAATV 727
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtrLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
38-225 3.10e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026  38 GAGGGTASSLSARPGLLPLPVVPSRLPTPATAPA-PCTTGSSEAITSLVASSASAVTTKAPGISKADSQSQGLATSIRWG 116
Cdd:PRK07003 366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVtAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADG 445

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 117 QTPInQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTliahsygvaqPPTFSPAvnvqAPVIGVTPSLPPHVG-P 195
Cdd:PRK07003 446 DAPV-PAKANARASADSRCDERDAQPPADSGSASAPASDAPP----------DAAFEPA----PRAAAPSAATPAAVPdA 510

                        170       180       190
                 ....*....|....*....|....*....|
gi 966980026 196 QLPLMPGHYSLPQPPSQPLSSVVVNMPAQA 225
Cdd:PRK07003 511 RAPAAASREDAPAAAAPPAPEARPPTPAAA 540
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
572-654 4.62e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 39.75  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 572 PRTRPRLSAGVAEVIVLVggrqmVGMTQRSLVAVTCWNPQNNKWYPLASLPFyDREFFSVVSAGDNIYLSGGM-ESGVTL 650
Cdd:COG3055  194 PTARAGHAAAVLGGKILV-----FGGESGFSDEVEAYDPATNTWTALGELPT-PRHGHAAVLTDGKVYVIGGEtKPGVRT 267


                 ....
gi 966980026 651 ADVW 654
Cdd:COG3055  268 PLVT 271
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 373-435 5.87e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 37.80  E-value: 5.87e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966980026 373 LELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18281   65 AEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 626-670 7.38e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 7.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 966980026  626 REFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 431-528 7.90e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 36.82  E-value: 7.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980026 431 LTASN-CLgVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLntKAEEL-VYETVIKWIKKD 508
Cdd:cd14822    1 LNIRNvCL-IYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSF--CAPEVdIFNAVRRWCEHN 77

                         90       100
                 ....*....|....*....|
gi 966980026 509 PaTRTQYAAELLAVVRLPFI 528
Cdd:cd14822   78 P-DSKEDAKEILEAVRLPLM 96
Kelch_6 pfam13964
Kelch motif;
626-673 8.34e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.39  E-value: 8.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 966980026  626 REFFSVVSAGDNIYLSGG-MESGVTLADVWCYmSLLDN-WNLVSRMTVPR 673
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVY-NPLTKsWEELPPLPTPR 50
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 329-401 8.34e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 37.24  E-value: 8.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966980026 329 TDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGgreklELVLSNLQADVLELLLEFVYTGSLVIDS 401
Cdd:cd18286   18 SDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSS-----EITLTGVSHAAVSFVLLFIYGGVLDLPD 85
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 723-764 9.43e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.00  E-value: 9.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 966980026  723 AAATVCGGKIYVFGGVNEAGRAAG-VLQSYVPQTNTWSFIESP 764
Cdd:pfam07646   5 HASSVPGGKLYVVGGSDGLGDLSSsDVLVYDPETNVWTEVPRL 47
Kelch smart00612
Kelch domain;
780-821 9.47e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.84  E-value: 9.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 966980026   780 VFILGGaYARATT-----IYDPEKGNIKAGPNMNHSRQFCSAVVLDG 821
Cdd:smart00612   2 IYVVGG-FDGGQRlksveVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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