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Conserved domains on  [gi|1622853057|ref|XP_014966989|]
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ankyrin repeat and MYND domain-containing protein 1 isoform X1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
80-186 2.38e-22

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 98.10  E-value: 2.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMYMK--TR 157
Cdd:COG4642    139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAdgDR 218

                           90       100
                   ....*....|....*....|....*....
gi 1622853057  158 lFQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:COG4642    219 -YEGEFKNGKRHGQGTLTYADGDRYEGEF 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
604-855 9.18e-21

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 9.18e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  604 RMALSMIERRKRWQTIKLLLRRGADPNLCRVPMQ-ALFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAAlp 682
Cdd:COG0666     55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNtLLHAAARNGDLEIVKLLLEAGA--DVNARDKDGE-TPLHLAAY-- 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  683 gEEGVQIVELLLHAITDVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEREDdnk 762
Cdd:COG0666    130 -NGNLEIVKLLLEAGADVNAQDND----------------------------------------GNTPLHLAAANGN--- 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  763 caRDVVQLLLSHRANPNLL-WSGHSPLSLSIASGNDLVVKELLTHGADPNLPLTKGlGSALCIACDLtyehqrsvdERLA 841
Cdd:COG0666    166 --LEIVKLLLEAGADVNARdNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG-KTALDLAAEN---------GNLE 233

                          250
                   ....*....|....
gi 1622853057  842 LIDRLINHGADILK 855
Cdd:COG0666    234 IVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
346-419 6.95e-10

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 6.95e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853057  346 ERLSTEMILKAEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666     85 DGGNTLLHAAARNGDLE-IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
zf-MYND pfam01753
MYND finger;
969-1009 1.90e-09

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 53.96  E-value: 1.90e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622853057  969 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWnEFHKKDC 1009
Cdd:pfam01753    1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
DUF2857 super family cl12747
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 565-640 8.66e-04

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


The actual alignment was detected with superfamily member pfam11198:

Pssm-ID: 431719  Cd Length: 174  Bit Score: 41.49  E-value: 8.66e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853057  565 NFSIELSQAMLERSAQSHSLLKMASPSLCTSSFDKGTMRRMALSMIERRKRWQTIKLLLRRGADPNLcrvpMQALF 640
Cdd:pfam11198   24 GFSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-186 2.38e-22

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 98.10  E-value: 2.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMYMK--TR 157
Cdd:COG4642    139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAdgDR 218

                           90       100
                   ....*....|....*....|....*....
gi 1622853057  158 lFQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:COG4642    219 -YEGEFKNGKRHGQGTLTYADGDRYEGEF 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
604-855 9.18e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 9.18e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  604 RMALSMIERRKRWQTIKLLLRRGADPNLCRVPMQ-ALFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAAlp 682
Cdd:COG0666     55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNtLLHAAARNGDLEIVKLLLEAGA--DVNARDKDGE-TPLHLAAY-- 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  683 gEEGVQIVELLLHAITDVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEREDdnk 762
Cdd:COG0666    130 -NGNLEIVKLLLEAGADVNAQDND----------------------------------------GNTPLHLAAANGN--- 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  763 caRDVVQLLLSHRANPNLL-WSGHSPLSLSIASGNDLVVKELLTHGADPNLPLTKGlGSALCIACDLtyehqrsvdERLA 841
Cdd:COG0666    166 --LEIVKLLLEAGADVNARdNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG-KTALDLAAEN---------GNLE 233

                          250
                   ....*....|....
gi 1622853057  842 LIDRLINHGADILK 855
Cdd:COG0666    234 IVKLLLEAGADLNA 247
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 85-186 1.11e-16

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 85.27  E-value: 1.11e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   85 WQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYG-TMYMKTRLFQGLY 163
Cdd:PLN03185    28 WSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGyQRYPNGDVFEGSW 107

                           90       100
                   ....*....|....*....|...
gi 1622853057  164 KADQRFGPGVETYPDGSQDVGLW 186
Cdd:PLN03185   108 IQGLQEGPGKYTWANGNVYLGDM 130
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 622-852 3.76e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 3.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  622 LLRRGADPNLCRVP-MQALFLAVKAGDVDGVRLLLEHGARTDICFPpqlGTLTPLHIAAalpgEEG-VQIVELLLHAITD 699
Cdd:PHA02875    21 LLDIGINPNFEIYDgISPIKLAMKFRDSEAIKLLMKHGAIPDVKYP---DIESELHDAV----EEGdVKAVEELLDLGKF 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  700 VDaeasdkDSTYKSGKLDLLPSSLKLSNEPGPPQAYYSMDTPLPEEGGRTALHMACEREDDNkcardVVQLLLSHRANPN 779
Cdd:PHA02875    94 AD------DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK-----GIELLIDHKACLD 162

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853057  780 LL-WSGHSPLSLSIASGNDLVVKELLTHGADPNLPLTKGLGSALCIACDltyehqrsvDERLALIDRLINHGAD 852
Cdd:PHA02875   163 IEdCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIE---------NNKIDIVRLFIKRGAD 227
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
346-419 6.95e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 6.95e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853057  346 ERLSTEMILKAEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666     85 DGGNTLLHAAARNGDLE-IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
Ank_2 pfam12796
Ankyrin repeats (3 copies);
747-812 9.04e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 9.04e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853057  747 GRTALHMACEREDdnkcaRDVVQLLLSHrANPNLLWSGHSPLSLSIASGNDLVVKELLTHGADPNL 812
Cdd:pfam12796   30 GRTALHLAAKNGH-----LEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
zf-MYND pfam01753
MYND finger;
969-1009 1.90e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 53.96  E-value: 1.90e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622853057  969 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWnEFHKKDC 1009
Cdd:pfam01753    1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 376-428 2.30e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.20  E-value: 2.30e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622853057  376 DVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLVYYP 428
Cdd:PHA03100   186 NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
356-419 1.83e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 1.83e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853057  356 AEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCgADVNKCsDEGLTAL 419
Cdd:pfam12796    5 AKNGNLE-LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTAL 65
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 114-136 6.42e-05

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 40.85  E-value: 6.42e-05
                           10        20
                   ....*....|....*....|...
gi 1622853057  114 YHGQFYRDHCHGLGTYTWPDGSS 136
Cdd:pfam02493    1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
113-133 4.01e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 38.48  E-value: 4.01e-04
                            10        20
                    ....*....|....*....|.
gi 1622853057   113 SYHGQFYRDHCHGLGTYTWPD 133
Cdd:smart00698    2 RYEGEWRNGKRHGRGVYTYAN 22
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 747-780 7.52e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 7.52e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1622853057   747 GRTALHMACEREDdnkcaRDVVQLLLSHRANPNL 780
Cdd:smart00248    2 GRTPLHLAAENGN-----LEVVKLLLDKGADINA 30
DUF2857 pfam11198
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 565-640 8.66e-04

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


Pssm-ID: 431719  Cd Length: 174  Bit Score: 41.49  E-value: 8.66e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853057  565 NFSIELSQAMLERSAQSHSLLKMASPSLCTSSFDKGTMRRMALSMIERRKRWQTIKLLLRRGADPNLcrvpMQALF 640
Cdd:pfam11198   24 GFSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 381-410 3.81e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 3.81e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1622853057   381 KGYTVLAAAATHCHNDIVNLLLDCGADVNK 410
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 747-810 5.03e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 40.63  E-value: 5.03e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622853057  747 GRTALHMACEREDDNkcardVVQLLLSHRAN--------------PNLLWSGHSPLSLSIASGNDLVVKELLTHGADP 810
Cdd:cd21882     73 GQTALHIAIENRNLN-----LVRLLVENGADvsaratgrffrkspGNLFYFGELPLSLAACTNQEEIVRLLLENGAQP 145
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-186 2.38e-22

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 98.10  E-value: 2.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMYMK--TR 157
Cdd:COG4642    139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAdgDR 218

                           90       100
                   ....*....|....*....|....*....
gi 1622853057  158 lFQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:COG4642    219 -YEGEFKNGKRHGQGTLTYADGDRYEGEF 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
604-855 9.18e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 9.18e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  604 RMALSMIERRKRWQTIKLLLRRGADPNLCRVPMQ-ALFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAAlp 682
Cdd:COG0666     55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNtLLHAAARNGDLEIVKLLLEAGA--DVNARDKDGE-TPLHLAAY-- 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  683 gEEGVQIVELLLHAITDVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEREDdnk 762
Cdd:COG0666    130 -NGNLEIVKLLLEAGADVNAQDND----------------------------------------GNTPLHLAAANGN--- 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  763 caRDVVQLLLSHRANPNLL-WSGHSPLSLSIASGNDLVVKELLTHGADPNLPLTKGlGSALCIACDLtyehqrsvdERLA 841
Cdd:COG0666    166 --LEIVKLLLEAGADVNARdNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG-KTALDLAAEN---------GNLE 233

                          250
                   ....*....|....
gi 1622853057  842 LIDRLINHGADILK 855
Cdd:COG0666    234 IVKLLLEAGADLNA 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-186 2.88e-20

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 91.94  E-value: 2.88e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMYMKT-RL 158
Cdd:COG4642    116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANgDV 195

                           90       100
                   ....*....|....*....|....*...
gi 1622853057  159 FQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:COG4642    196 YEGEFKNGQRHGQGTYTYADGDRYEGEF 223
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-186 2.43e-19

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 89.25  E-value: 2.43e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMymktrlf 159
Cdd:COG4642    185 QGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTM------- 257

                           90       100
                   ....*....|....*....|....*..
gi 1622853057  160 qglykadqrfgpgveTYPDGSQDVGLW 186
Cdd:COG4642    258 ---------------TYADGSVYEGEW 269
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
619-853 4.93e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.86  E-value: 4.93e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  619 IKLLLRRGADPNLCRVPMQALFLAVKAGDVDGVRLLLEHGARTDIcfpPQLGTLTPLHIAAAlpgEEGVQIVELLLHAIT 698
Cdd:COG0666     38 LLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA---KDDGGNTLLHAAAR---NGDLEIVKLLLEAGA 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  699 DVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEREDDnkcarDVVQLLLSHRANP 778
Cdd:COG0666    112 DVNARDKD----------------------------------------GETPLHLAAYNGNL-----EIVKLLLEAGADV 146

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853057  779 NLL-WSGHSPLSLSIASGNDLVVKELLTHGADPNLPLTKGlGSALCIACDltyehqrsvDERLALIDRLINHGADI 853
Cdd:COG0666    147 NAQdNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDG-ETPLHLAAE---------NGHLEIVKLLLEAGADV 212
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 85-186 1.11e-16

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 85.27  E-value: 1.11e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   85 WQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYG-TMYMKTRLFQGLY 163
Cdd:PLN03185    28 WSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGyQRYPNGDVFEGSW 107

                           90       100
                   ....*....|....*....|...
gi 1622853057  164 KADQRFGPGVETYPDGSQDVGLW 186
Cdd:PLN03185   108 IQGLQEGPGKYTWANGNVYLGDM 130
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
606-854 1.52e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 75.38  E-value: 1.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  606 ALSMIERRKRWQTIKLLLRRGADPNLC-RVPMQALFLAVKAGDVDGVRLLLEHGArtdicfppqlgtltplhiaaalpge 684
Cdd:COG0666    123 PLHLAAYNGNLEIVKLLLEAGADVNAQdNDGNTPLHLAAANGNLEIVKLLLEAGA------------------------- 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  685 egvqivelllhaitDVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEREDDnkca 764
Cdd:COG0666    178 --------------DVNARDND----------------------------------------GETPLHLAAENGHL---- 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  765 rDVVQLLLSHRANPNLL-WSGHSPLSLSIASGNDLVVKELLTHGADPNLPLTKGLGSALCIACDLTYEHQRSVDERLALI 843
Cdd:COG0666    200 -EIVKLLLEAGADVNAKdNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278

                          250
                   ....*....|.
gi 1622853057  844 DRLINHGADIL 854
Cdd:COG0666    279 AAALLDLLTLL 289
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 622-852 3.76e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 3.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  622 LLRRGADPNLCRVP-MQALFLAVKAGDVDGVRLLLEHGARTDICFPpqlGTLTPLHIAAalpgEEG-VQIVELLLHAITD 699
Cdd:PHA02875    21 LLDIGINPNFEIYDgISPIKLAMKFRDSEAIKLLMKHGAIPDVKYP---DIESELHDAV----EEGdVKAVEELLDLGKF 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  700 VDaeasdkDSTYKSGKLDLLPSSLKLSNEPGPPQAYYSMDTPLPEEGGRTALHMACEREDDNkcardVVQLLLSHRANPN 779
Cdd:PHA02875    94 AD------DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK-----GIELLIDHKACLD 162

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853057  780 LL-WSGHSPLSLSIASGNDLVVKELLTHGADPNLPLTKGLGSALCIACDltyehqrsvDERLALIDRLINHGAD 852
Cdd:PHA02875   163 IEdCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIE---------NNKIDIVRLFIKRGAD 227
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
77-186 1.69e-12

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 68.83  E-value: 1.69e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   77 QLVQGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMYMKT 156
Cdd:COG4642     90 DGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYAD 169

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1622853057  157 -RLFQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:COG4642    170 gDRYEGEFKNGKRHGQGTLTYANGDVYEGEF 200
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 602-809 3.84e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 3.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  602 MRRMALSMIERRKRWQTIKLLLRRGADPN------LCRVPMQALFLAVKAGDVDGVRLLLEHGARTDICFPPQlgtLTPL 675
Cdd:PHA03100    34 KPVLPLYLAKEARNIDVVKILLDNGADINsstknnSTPLHYLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNG---ITPL 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  676 HIAAALPGEEgVQIVELLLHAITDVDAEASDKDSTY----KSGKLDLLPSSLKLSNepgppQAY------------YSMD 739
Cdd:PHA03100   111 LYAISKKSNS-YSIVEYLLDNGANVNIKNSDGENLLhlylESNKIDLKILKLLIDK-----GVDinaknrvnyllsYGVP 184

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622853057  740 TPLPEEGGRTALHMACERedDNKcarDVVQLLLSHRANPNLL-WSGHSPLSLSIASGNDLVVKELLTHGAD 809
Cdd:PHA03100   185 INIKDVYGFTPLHYAVYN--NNP---EFVKYLLDLGANPNLVnKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
346-419 6.95e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 6.95e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853057  346 ERLSTEMILKAEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666     85 DGGNTLLHAAARNGDLE-IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
Ank_2 pfam12796
Ankyrin repeats (3 copies);
747-812 9.04e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 9.04e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853057  747 GRTALHMACEREDdnkcaRDVVQLLLSHrANPNLLWSGHSPLSLSIASGNDLVVKELLTHGADPNL 812
Cdd:pfam12796   30 GRTALHLAAKNGH-----LEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 79-155 1.22e-09

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 62.54  E-value: 1.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   79 VQGVQE------WQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTM 152
Cdd:PLN03185   108 IQGLQEgpgkytWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF 187


                   ...
gi 1622853057  153 YMK 155
Cdd:PLN03185   188 YPA 190
zf-MYND pfam01753
MYND finger;
969-1009 1.90e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 53.96  E-value: 1.90e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622853057  969 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWnEFHKKDC 1009
Cdd:pfam01753    1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
350-419 1.91e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 1.91e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  350 TEMILKAEEGNHDWIcGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666    122 TPLHLAAYNGNLEIV-KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL 190
Ank_2 pfam12796
Ankyrin repeats (3 copies);
618-702 4.18e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 4.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  618 TIKLLLRRGADPNLCRV-PMQALFLAVKAGDVDGVRLLLEHGARTDicfppQLGTLTPLHIAAalpgEEG-VQIVELLLH 695
Cdd:pfam12796   12 LVKLLLENGADANLQDKnGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                   ....*..
gi 1622853057  696 AITDVDA 702
Cdd:pfam12796   83 KGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
639-780 1.79e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 1.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  639 LFLAVKAGDVDGVRLLLEHGARTDICFPPQlgtLTPLHIAAAlpgEEGVQIVELLL-HAITDVDAEasdkdstyksgkld 717
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNG---RTALHLAAK---NGHLEIVKLLLeHADVNLKDN-------------- 60

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622853057  718 llpsslklsnepgppqayysmdtplpeegGRTALHMACEreddnKCARDVVQLLLSHRANPNL 780
Cdd:pfam12796   61 -----------------------------GRTALHYAAR-----SGHLEIVKLLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
356-421 2.77e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.50  E-value: 2.77e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853057  356 AEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSM 421
Cdd:COG0666    161 AANGNLE-IVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 87-186 1.20e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 55.99  E-value: 1.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   87 DGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTmYMKTR--LFQGLYK 164
Cdd:PLN03185     7 NGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGTDgtTYKGRWR 85

                           90       100
                   ....*....|....*....|..
gi 1622853057  165 ADQRFGPGVETYPDGSQDVGLW 186
Cdd:PLN03185    86 LNLKHGLGYQRYPNGDVFEGSW 107
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 376-428 2.30e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.20  E-value: 2.30e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622853057  376 DVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLVYYP 428
Cdd:PHA03100   186 NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
350-419 2.56e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.34  E-value: 2.56e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  350 TEMILKAEEGNHDWICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666     55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPL 124
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 80-186 3.55e-06

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 50.99  E-value: 3.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGT-MYMKTRL 158
Cdd:PLN03185    46 NGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKyTWANGNV 125

                           90       100
                   ....*....|....*....|....*...
gi 1622853057  159 FQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:PLN03185   126 YLGDMKGGKMSGKGTLTWVSGDSYEGQW 153
Ank_2 pfam12796
Ankyrin repeats (3 copies);
751-853 3.77e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.26  E-value: 3.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  751 LHMACEREDdnkcaRDVVQLLLSHRANPNLLWS-GHSPLSLSIASGNDLVVKELLTHgADPNLPlTKGLgSALCIACDLt 829
Cdd:pfam12796    1 LHLAAKNGN-----LELVKLLLENGADANLQDKnGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGR-TALHYAARS- 71

                           90       100
                   ....*....|....*....|....
gi 1622853057  830 yehqrsvdERLALIDRLINHGADI 853
Cdd:pfam12796   72 --------GHLEIVKLLLEKGADI 87
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 747-780 1.47e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 42.66  E-value: 1.47e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622853057  747 GRTALHMACEREDDnkcaRDVVQLLLSHRANPNL 780
Cdd:pfam00023    2 GNTPLHLAAGRRGN----LEIVKLLLSKGADVNA 31
PHA03095 PHA03095
ankyrin-like protein; Provisional
 619-812 1.49e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.87  E-value: 1.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  619 IKLLLRRGADPNLC----RVPMQAlFLAVKAGDVDGVRLLLEHGArtDICFPPQLGtLTPLHIAAALPGEEgVQIVELLL 694
Cdd:PHA03095   100 IKLLIKAGADVNAKdkvgRTPLHV-YLSGFNINPKVIRLLLRKGA--DVNALDLYG-MTPLAVLLKSRNAN-VELLRLLI 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  695 HAITDVdaeaSDKDSTYKSgKLDLLPSSLKLSNEPGPPQAYYSMDTPLPEEGGRTALHMACEReddNKCARDVVQLLLSH 774
Cdd:PHA03095   175 DAGADV----YAVDDRFRS-LLHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATG---SSCKRSLVLPLLIA 246

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1622853057  775 RANPNLL-WSGHSPLSLSIASGNDLVVKELLTHGADPNL 812
Cdd:PHA03095   247 GISINARnRYGQTPLHYAAVFNNPRACRRLIALGADINA 285
Ank_2 pfam12796
Ankyrin repeats (3 copies);
356-419 1.83e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 1.83e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853057  356 AEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCgADVNKCsDEGLTAL 419
Cdd:pfam12796    5 AKNGNLE-LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTAL 65
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 606-792 2.34e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.34  E-value: 2.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  606 ALSMIERRKRWQTIKLLLRRGADPN-LCRVPMQALFLAVKAGDVDGVRLLLEHGARTDIcfPPQLGTlTPLHIAAALPge 684
Cdd:PHA02878   171 ALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA--RDKCGN-TPLHISVGYC-- 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  685 EGVQIVELLLHAITDVDAEASDKdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEREddnkca 764
Cdd:PHA02878   246 KDYDILKLLLEHGVDVNAKSYIL---------------------------------------GLTALHSSIKSE------ 280

                          170       180
                   ....*....|....*....|....*....
gi 1622853057  765 rDVVQLLLSHRANPNLL-WSGHSPLSLSI 792
Cdd:PHA02878   281 -RKLKLLLEYGADINSLnSYKLTPLSSAV 308
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 651-826 2.98e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 2.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  651 VRLLLEHGARTDICFPPQLGtlTPLHIAAALPGEEgvqIVELLLhaitDVDAEASDKDSTYKSGkldlLPSSLKLSNEPG 730
Cdd:PHA02878   150 TKLLLSYGADINMKDRHKGN--TALHYATENKDQR---LTELLL----SYGANVNIPDKTNNSP----LHHAVKHYNKPI 216

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  731 PPQAY-YSMDTPLPEEGGRTALHMACEREDDnkcaRDVVQLLLSHRANPNLLWS--GHSPLSLSIASgnDLVVKELLTHG 807
Cdd:PHA02878   217 VHILLeNGASTDARDKCGNTPLHISVGYCKD----YDILKLLLEHGVDVNAKSYilGLTALHSSIKS--ERKLKLLLEYG 290

                          170       180
                   ....*....|....*....|....*.
gi 1622853057  808 ADPNL-------PLTKGLGSALCIAC 826
Cdd:PHA02878   291 ADINSlnsykltPLSSAVKQYLCINI 316
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 631-853 6.13e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 6.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  631 LCRVPMQALFLAVKAGDVDGVRLLLEHGARTDIcfpPQLGTLTPLHIAAALPG--EEGVQIVELLLHAITDVDAeasdkd 708
Cdd:PHA03100    31 SYKKPVLPLYLAKEARNIDVVKILLDNGADINS---STKNNSTPLHYLSNIKYnlTDVKEIVKLLLEYGANVNA------ 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  709 sTYKSGKLDLLPSSLKLSNepgppqaYYSMDTPLPEEG---------GRTALHMACEREDDNKcarDVVQLLLSHRANPN 779
Cdd:PHA03100   102 -PDNNGITPLLYAISKKSN-------SYSIVEYLLDNGanvniknsdGENLLHLYLESNKIDL---KILKLLIDKGVDIN 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  780 ------LLWS-----------GHSPLSLSIASGNDLVVKELLTHGADPNLPLTKGLgSALCIACDltyehqrsvDERLAL 842
Cdd:PHA03100   171 aknrvnYLLSygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGD-TPLHIAIL---------NNNKEI 240

                          250
                   ....*....|.
gi 1622853057  843 IDRLINHGADI 853
Cdd:PHA03100   241 FKLLLNNGPSI 251
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 114-136 6.42e-05

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 40.85  E-value: 6.42e-05
                           10        20
                   ....*....|....*....|...
gi 1622853057  114 YHGQFYRDHCHGLGTYTWPDGSS 136
Cdd:pfam02493    1 YEGEWKNGKRHGKGVYTWPDGDR 23
Ank_4 pfam13637
Ankyrin repeats (many copies);
382-419 1.54e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 1.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622853057  382 GYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETAL 38
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 607-701 1.89e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 1.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853057  607 LSMIERRKRWQTIKLLLRRGADPNLCRVP-MQALFLAVKAGDVDGVRLLLEHGARTDI--CFppqlgTLTPLHIAAAlpg 683
Cdd:PHA02875   106 LHLATILKKLDIMKLLIARGADPDIPNTDkFSPLHLAVMMGDIKGIELLIDHKACLDIedCC-----GCTPLIIAMA--- 177

                           90
                   ....*....|....*...
gi 1622853057  684 EEGVQIVELLLHAITDVD 701
Cdd:PHA02875   178 KGDIAICKMLLDSGANID 195
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
113-133 4.01e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 38.48  E-value: 4.01e-04
                            10        20
                    ....*....|....*....|.
gi 1622853057   113 SYHGQFYRDHCHGLGTYTWPD 133
Cdd:smart00698    2 RYEGEWRNGKRHGRGVYTYAN 22
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 747-780 7.52e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 7.52e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1622853057   747 GRTALHMACEREDdnkcaRDVVQLLLSHRANPNL 780
Cdd:smart00248    2 GRTPLHLAAENGN-----LEVVKLLLDKGADINA 30
DUF2857 pfam11198
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 565-640 8.66e-04

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


Pssm-ID: 431719  Cd Length: 174  Bit Score: 41.49  E-value: 8.66e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853057  565 NFSIELSQAMLERSAQSHSLLKMASPSLCTSSFDKGTMRRMALSMIERRKRWQTIKLLLRRGADPNLcrvpMQALF 640
Cdd:pfam11198   24 GFSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
Ank_2 pfam12796
Ankyrin repeats (3 copies);
356-409 1.28e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.94  E-value: 1.28e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622853057  356 AEEGNHDwICGILKDNFASADVADakGYTVLAAAATHCHNDIVNLLLDCGADVN 409
Cdd:pfam12796   38 AKNGHLE-IVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVKLLLEKGADIN 88
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 381-413 1.40e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 1.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622853057  381 KGYTVL-AAAATHCHNDIVNLLLDCGADVNKCSD 413
Cdd:pfam00023    1 DGNTPLhLAAGRRGNLEIVKLLLSKGADVNARDK 34
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
356-419 2.06e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.48  E-value: 2.06e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853057  356 AEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666    194 AENGHLE-IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
Ank_2 pfam12796
Ankyrin repeats (3 copies);
386-419 2.07e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.56  E-value: 2.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622853057  386 LAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTAL 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
636-694 2.99e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 2.99e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622853057  636 MQALFLAVKAGDVDGVRLLLEHGA---RTDICFppqlgtLTPLHIAAAlpgEEGVQIVELLL 694
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGAdinAVDGNG------ETALHFAAS---NGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 381-410 3.81e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 3.81e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1622853057   381 KGYTVLAAAATHCHNDIVNLLLDCGADVNK 410
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
367-422 4.14e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 4.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853057  367 ILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMC 422
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 747-810 5.03e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 40.63  E-value: 5.03e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622853057  747 GRTALHMACEREDDNkcardVVQLLLSHRAN--------------PNLLWSGHSPLSLSIASGNDLVVKELLTHGADP 810
Cdd:cd21882     73 GQTALHIAIENRNLN-----LVRLLVENGADvsaratgrffrkspGNLFYFGELPLSLAACTNQEEIVRLLLENGAQP 145
Ank_2 pfam12796
Ankyrin repeats (3 copies);
617-663 5.04e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 5.04e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622853057  617 QTIKLLLRRgADPNLCRVPMQALFLAVKAGDVDGVRLLLEHGARTDI 663
Cdd:pfam12796   44 EIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 381-410 5.71e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 5.71e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622853057  381 KGYTVLAAAATHCHNDIVNLLLDCGADVNK 410
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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