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Conserved domains on  [gi|966976278|ref|XP_014965548|]
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origin recognition complex subunit 4 isoform X2 [Macaca mulatta]

Protein Classification

origin recognition complex subunit 4( domain architecture ID 13386334)

origin recognition complex subunit 4 is a component of the origin recognition complex (ORC), an ATP-dependent DNA-binding complex that binds origins of replication

CATH:  3.40.50.300
Gene Symbol:  ORC4
Gene Ontology:  GO:0006270|GO:0006260|GO:0005524|GO:0000808|GO:0003688
PubMed:  20130679|18208389|18466635|16828312|15037233|17241905
SCOP:  4000172|4000283

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 212-399 1.81e-61

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


:

Pssm-ID: 464223  Cd Length: 212  Bit Score: 197.95  E-value: 1.81e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  212 KIFKEQLSLPAEF----PDKLFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLTLNRVTASHPFMTAIDLM 287
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  288 EASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRK-------------AHSVYNFEKP 354
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966976278  355 VVMKAFEHLQQLELIKPMERTSGNS-------QREYQLMKLLLDNTQIMNAL 399
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGAVSTGGassgsggGKEFRMVRLDITLEEIREAV 212
CDC6 super family cl34277
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
27-210 1.23e-18

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1474:

Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 86.83  E-value: 1.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  27 QYKHISELLkRTALHGES-NSVLIIGPRGSGKTMLINHALKELMEI-EEVSENVLQVHLNglLQINDKI--ALKEITRQL 102
Cdd:COG1474   34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEaEERGVDVRVVYVN--CRQASTRyrVLSRILEEL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278 103 NLENVVGDKvfG-SFAENLSFLLEALKKGDRtsscPVIFILDEFDLFAHHKNQTLLYNLFDISQS-AQTPIAVIGLTCRL 180
Cdd:COG1474  111 GSGEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGISNDL 184

                        170       180       190
                 ....*....|....*....|....*....|
gi 966976278 181 DILELLEKRVKSRFSHRQIHlmnsfgFPQY 210
Cdd:COG1474  185 EFLENLDPRVKSSLGEEEIV------FPPY 208
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 212-399 1.81e-61

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 197.95  E-value: 1.81e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  212 KIFKEQLSLPAEF----PDKLFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLTLNRVTASHPFMTAIDLM 287
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  288 EASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRK-------------AHSVYNFEKP 354
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966976278  355 VVMKAFEHLQQLELIKPMERTSGNS-------QREYQLMKLLLDNTQIMNAL 399
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGAVSTGGassgsggGKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
27-210 1.23e-18

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 86.83  E-value: 1.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  27 QYKHISELLkRTALHGES-NSVLIIGPRGSGKTMLINHALKELMEI-EEVSENVLQVHLNglLQINDKI--ALKEITRQL 102
Cdd:COG1474   34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEaEERGVDVRVVYVN--CRQASTRyrVLSRILEEL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278 103 NLENVVGDKvfG-SFAENLSFLLEALKKGDRtsscPVIFILDEFDLFAHHKNQTLLYNLFDISQS-AQTPIAVIGLTCRL 180
Cdd:COG1474  111 GSGEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGISNDL 184

                        170       180       190
                 ....*....|....*....|....*....|
gi 966976278 181 DILELLEKRVKSRFSHRQIHlmnsfgFPQY 210
Cdd:COG1474  185 EFLENLDPRVKSSLGEEEIV------FPPY 208
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 29-210 2.18e-15

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 76.90  E-value: 2.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   29 KHISELLK--RTALHGE-SNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHlngllQINDKI------ALKEIT 99
Cdd:TIGR02928  22 EQIEELAKalRPILRGSrPSNVFIYGKTGTGKTAVTKYVMKELEEAAEDRDVRVVTV-----YVNCQIldtlyqVLVELA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  100 RQLNlenVVGDKV--FG-SFAENLSFLLEALKKGDRTsscpVIFILDEFDLFAHHKNqTLLYNLFDISQSAQT---PIAV 173
Cdd:TIGR02928  97 NQLR---GSGEEVptTGlSTSEVFRRLYKELNERGDS----LIIVLDEIDYLVGDDD-DLLYQLSRARSNGDLdnaKVGV 168

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 966976278  174 IGLTCRLDILELLEKRVKSRFSHRQIHlmnsfgFPQY 210
Cdd:TIGR02928 169 IGISNDLKFRENLDPRVKSSLCEEEII------FPPY 199
cdc6 PRK00411
ORC1-type DNA replication protein;
37-210 1.26e-12

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 68.72  E-value: 1.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  37 RTALHGESNS-VLIIGPRGSGKTMLInhaLKELMEIEEVSENVLQVHLNGllQIND---KIaLKEITRQLNLENV--VG- 109
Cdd:PRK00411  47 RPALRGSRPLnVLIYGPPGTGKTTTV---KKVFEELEEIAVKVVYVYINC--QIDRtryAI-FSEIARQLFGHPPpsSGl 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278 110 --DKVFGSFAEnlsflleALKKGDRTsscpVIFILDEFD-LFAHHKNQTLlYNLFDISQSAQ-TPIAVIGLTCRLDILEL 185
Cdd:PRK00411 121 sfDELFDKIAE-------YLDERDRV----LIVALDDINyLFEKEGNDVL-YSLLRAHEEYPgARIGVIGISSDLTFLYI 188

                        170       180
                 ....*....|....*....|....*
gi 966976278 186 LEKRVKSRFSHRQIHlmnsfgFPQY 210
Cdd:PRK00411 189 LDPRVKSVFRPEEIY------FPPY 207
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 30-197 6.16e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 54.46  E-value: 6.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  30 HISELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELmeiEEVSENVLQVHLNGLLQINdkialkeitrqlnlenvVG 109
Cdd:cd00009    5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL---FRPGAPFLYLNASDLLEGL-----------------VV 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278 110 DKVFGSFAENLSFLLEALKKGDrtsscpvIFILDEFDLFAHHKNQTLLYNL--FDISQSAQTPIAVIGLTCRLDILELLE 187
Cdd:cd00009   65 AELFGHFLVRLLFELAEKAKPG-------VLFIDEIDSLSRGAQNALLRVLetLNDLRIDRENVRVIGATNRPLLGDLDR 137

                        170
                 ....*....|
gi 966976278 188 KRvKSRFSHR 197
Cdd:cd00009  138 AL-YDRLDIR 146
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 20-174 1.67e-07

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 50.58  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   20 NLFGVQVQYKHISELLKRTAlHGESNSVLIIGPRGSGKTMLINHALKELmeiEEVSENVLQ---VHLNGLLQINDKIALK 96
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVR-SGRPPSVLLTGEAGTGKTTLLRELLRAL---ERDGGYFLRgkcDENLPYSPLLEALTRE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   97 EITRQLNLENVV----------------GDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHkNQTLLYNL 160
Cdd:pfam13191  77 GLLRQLLDELESslleawraallealapVPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEA-SLQLLAAL 155

                         170
                  ....*....|....
gi 966976278  161 FDISQsaQTPIAVI 174
Cdd:pfam13191 156 LRLLE--SLPLLVV 167
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 45-201 3.50e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 49.29  E-value: 3.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278    45 NSVLIIGPRGSGKTMLINHALKElmeieevsenvLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLL 124
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARE-----------LGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLAL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   125 EALKKgdrtsSCPVIFILDEFDLFAHHKNQTLL----YNLFDISQSAQTPIAVIGLTcrLDILELLEKRVKSRFSHRQIH 200
Cdd:smart00382  72 ALARK-----LKPDVLILDEITSLLDAEQEALLllleELRLLLLLKSEKNLTVILTT--NDEKDLGPALLRRRFDRRIVL 144


                   .
gi 966976278   201 L 201
Cdd:smart00382 145 L 145
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
 212-399 1.81e-61

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 197.95  E-value: 1.81e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  212 KIFKEQLSLPAEF----PDKLFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLTLNRVTASHPFMTAIDLM 287
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  288 EASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRK-------------AHSVYNFEKP 354
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966976278  355 VVMKAFEHLQQLELIKPMERTSGNS-------QREYQLMKLLLDNTQIMNAL 399
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGAVSTGGassgsggGKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
27-210 1.23e-18

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 86.83  E-value: 1.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  27 QYKHISELLkRTALHGES-NSVLIIGPRGSGKTMLINHALKELMEI-EEVSENVLQVHLNglLQINDKI--ALKEITRQL 102
Cdd:COG1474   34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEaEERGVDVRVVYVN--CRQASTRyrVLSRILEEL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278 103 NLENVVGDKvfG-SFAENLSFLLEALKKGDRtsscPVIFILDEFDLFAHHKNQTLLYNLFDISQS-AQTPIAVIGLTCRL 180
Cdd:COG1474  111 GSGEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGISNDL 184

                        170       180       190
                 ....*....|....*....|....*....|
gi 966976278 181 DILELLEKRVKSRFSHRQIHlmnsfgFPQY 210
Cdd:COG1474  185 EFLENLDPRVKSSLGEEEIV------FPPY 208
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 29-210 2.18e-15

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 76.90  E-value: 2.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   29 KHISELLK--RTALHGE-SNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHlngllQINDKI------ALKEIT 99
Cdd:TIGR02928  22 EQIEELAKalRPILRGSrPSNVFIYGKTGTGKTAVTKYVMKELEEAAEDRDVRVVTV-----YVNCQIldtlyqVLVELA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  100 RQLNlenVVGDKV--FG-SFAENLSFLLEALKKGDRTsscpVIFILDEFDLFAHHKNqTLLYNLFDISQSAQT---PIAV 173
Cdd:TIGR02928  97 NQLR---GSGEEVptTGlSTSEVFRRLYKELNERGDS----LIIVLDEIDYLVGDDD-DLLYQLSRARSNGDLdnaKVGV 168

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 966976278  174 IGLTCRLDILELLEKRVKSRFSHRQIHlmnsfgFPQY 210
Cdd:TIGR02928 169 IGISNDLKFRENLDPRVKSSLCEEEII------FPPY 199
cdc6 PRK00411
ORC1-type DNA replication protein;
37-210 1.26e-12

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 68.72  E-value: 1.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  37 RTALHGESNS-VLIIGPRGSGKTMLInhaLKELMEIEEVSENVLQVHLNGllQIND---KIaLKEITRQLNLENV--VG- 109
Cdd:PRK00411  47 RPALRGSRPLnVLIYGPPGTGKTTTV---KKVFEELEEIAVKVVYVYINC--QIDRtryAI-FSEIARQLFGHPPpsSGl 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278 110 --DKVFGSFAEnlsflleALKKGDRTsscpVIFILDEFD-LFAHHKNQTLlYNLFDISQSAQ-TPIAVIGLTCRLDILEL 185
Cdd:PRK00411 121 sfDELFDKIAE-------YLDERDRV----LIVALDDINyLFEKEGNDVL-YSLLRAHEEYPgARIGVIGISSDLTFLYI 188

                        170       180
                 ....*....|....*....|....*
gi 966976278 186 LEKRVKSRFSHRQIHlmnsfgFPQY 210
Cdd:PRK00411 189 LDPRVKSVFRPEEIY------FPPY 207
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 30-197 6.16e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 54.46  E-value: 6.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  30 HISELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELmeiEEVSENVLQVHLNGLLQINdkialkeitrqlnlenvVG 109
Cdd:cd00009    5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL---FRPGAPFLYLNASDLLEGL-----------------VV 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278 110 DKVFGSFAENLSFLLEALKKGDrtsscpvIFILDEFDLFAHHKNQTLLYNL--FDISQSAQTPIAVIGLTCRLDILELLE 187
Cdd:cd00009   65 AELFGHFLVRLLFELAEKAKPG-------VLFIDEIDSLSRGAQNALLRVLetLNDLRIDRENVRVIGATNRPLLGDLDR 137

                        170
                 ....*....|
gi 966976278 188 KRvKSRFSHR 197
Cdd:cd00009  138 AL-YDRLDIR 146
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 20-174 1.67e-07

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 50.58  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   20 NLFGVQVQYKHISELLKRTAlHGESNSVLIIGPRGSGKTMLINHALKELmeiEEVSENVLQ---VHLNGLLQINDKIALK 96
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVR-SGRPPSVLLTGEAGTGKTTLLRELLRAL---ERDGGYFLRgkcDENLPYSPLLEALTRE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   97 EITRQLNLENVV----------------GDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHkNQTLLYNL 160
Cdd:pfam13191  77 GLLRQLLDELESslleawraallealapVPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEA-SLQLLAAL 155

                         170
                  ....*....|....
gi 966976278  161 FDISQsaQTPIAVI 174
Cdd:pfam13191 156 LRLLE--SLPLLVV 167
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 45-201 3.50e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 49.29  E-value: 3.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278    45 NSVLIIGPRGSGKTMLINHALKElmeieevsenvLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLL 124
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARE-----------LGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLAL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   125 EALKKgdrtsSCPVIFILDEFDLFAHHKNQTLL----YNLFDISQSAQTPIAVIGLTcrLDILELLEKRVKSRFSHRQIH 200
Cdd:smart00382  72 ALARK-----LKPDVLILDEITSLLDAEQEALLllleELRLLLLLKSEKNLTVILTT--NDEKDLGPALLRRRFDRRIVL 144


                   .
gi 966976278   201 L 201
Cdd:smart00382 145 L 145
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
29-269 1.99e-06

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 50.19  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  29 KHISELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNgllqindkiaLKEITRQLNLENVV 108
Cdd:COG5635  165 ERIESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIPILIE----------LRDLAEEASLEDLL 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278 109 GDKVFGSFAENLSFLLEALKKGdrtsscPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIgLTCR--------- 179
Cdd:COG5635  235 AEALEKRGGEPEDALERLLRNG------RLLLLLDGLDEVPDEADRDEVLNQLRRFLERYPKARVI-ITSRpegydssel 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278 180 --LDILELLEkrvksrFSHRQIhlmnsfgfpqyvkifkeqlslpaefpdKLFAEKWNENVQYLSEDrsVQEVLQKHFNIS 257
Cdd:COG5635  308 egFEVLELAP------LSDEQI---------------------------EEFLKKWFEATERKAER--LLEALEENPELR 352

                        250
                 ....*....|....*
gi 966976278 258 KNLRS---LHMLLML 269
Cdd:COG5635  353 ELARNpllLTLLALL 367
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
29-145 1.05e-05

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 47.22  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  29 KHISELLKRTALHGESNsVLIIGPRGSGKTMLINHALKElmeieevsENVlqVHLNgLLQINDKIALKEITRQLN--LEN 106
Cdd:COG1672    7 EELEELEKLYESDGGEL-VVVYGRRRVGKTSLIKEFLKE--------KPA--IYFD-AREESERESLRDFSEALAeaLGD 74

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966976278 107 VVGDKVFGSFAENLSFLLEALKKGdrtsscPVIFILDEF 145
Cdd:COG1672   75 PLSKKEFESWEEAFEYLAELAEGK------RLVIVIDEF 107
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 47-198 1.19e-05

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 44.51  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   47 VLIIGPRGSGKTMLInHALkelmeIEEVSENVLQVHLNGLLqindkialkeitrqlnlenvvgDKVFGSFAENLSFLLEA 126
Cdd:pfam00004   1 LLLYGPPGTGKTTLA-KAV-----AKELGAPFIEISGSELV----------------------SKYVGESEKRLRELFEA 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  127 LKKgdrtSSCPVIFIlDEFDLFAHHKN----------QTLLYNLFDISQSAQTPIAVIGLTCRLDileLLEKRVKSRFSH 196
Cdd:pfam00004  53 AKK----LAPCVIFI-DEIDALAGSRGsggdsesrrvVNQLLTELDGFTSSNSKVIVIAATNRPD---KLDPALLGRFDR 124


                  ..
gi 966976278  197 RQ 198
Cdd:pfam00004 125 II 126
AAA_22 pfam13401
AAA domain;
40-174 3.68e-04

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 40.40  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   40 LHGESNSVLIIGPRGSGKTMLINHALKELmeiEEVSENVLQV---HLNGLLQIndkiaLKEITRQLNLEnvvgdkvfGSF 116
Cdd:pfam13401   1 IRFGAGILVLTGESGTGKTTLLRRLLEQL---PEVRDSVVFVdlpSGTSPKDL-----LRALLRALGLP--------LSG 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 966976278  117 AENLSFLLEALKKGDRTSSCPVIFILDEfdlfAHHKNQTLLYNLFDISQSAQTPIAVI 174
Cdd:pfam13401  65 RLSKEELLAALQQLLLALAVAVVLIIDE----AQHLSLEALEELRDLLNLSSKLLQLI 118
PTZ00112 PTZ00112
origin recognition complex 1 protein; Provisional
 44-261 1.30e-03

origin recognition complex 1 protein; Provisional


Pssm-ID: 240274 [Multi-domain]  Cd Length: 1164  Bit Score: 41.13  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   44 SNSVLII-GPRGSGKTMLInHALKELMEIEEVSE-----NVLQVhlNGLLQINDKIALKEITRQLNleNVVGDKVFGSFa 117
Cdd:PTZ00112  780 SNQILYIsGMPGTGKTATV-YSVIQLLQHKTKQKllpsfNVFEI--NGMNVVHPNAAYQVLYKQLF--NKKPPNALNSF- 853

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  118 ENLSFLLEALKKGDRTSScpvIFILDEFDlFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHR 197
Cdd:PTZ00112  854 KILDRLFNQNKKDNRNVS---ILIIDEID-YLITKTQKVLFTLFDWPTKINSKLVLIAISNTMDLPERLIPRCRSRLAFG 929

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966976278  198 QIhLMNSFGFPQYVKIFKEQLslpaefpdklfaekwnENVQYLSEDRSVQEVLQKHFNISKNLR 261
Cdd:PTZ00112  930 RL-VFSPYKGDEIEKIIKERL----------------ENCKEIIDHTAIQLCARKVANVSGDIR 976
ATPase_2 pfam01637
ATPase domain predominantly from Archaea; This family contain a conserved P-loop motif that is ...
 29-242 5.08e-03

ATPase domain predominantly from Archaea; This family contain a conserved P-loop motif that is involved in binding ATP. There are eukaryote members as well as archaeal members in this family.


Pssm-ID: 376582 [Multi-domain]  Cd Length: 222  Bit Score: 38.07  E-value: 5.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278   29 KHISELLKRtaLHGESNSVLII-GPRGSGKTMLINHALKELMEIEE--VSENVLQvhlngllqiNDKIALKEITRQLN-L 104
Cdd:pfam01637   6 KELKELEEW--AERGPNLIYVIyGPEGCGKTALLRESIENLLDLGYyvIYYDPLR---------RYFISKLDRFEEVRrL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966976278  105 ENVVGDKVFGSFAE-------NLSFLLEALKKGDRTsscPVIFILDEFDLFAHHKNQTL---LYNLFDISQSAQTPIAVI 174
Cdd:pfam01637  75 AEALGIAVPKAELEesklaflAIELLLEALKRRGKK---IAIIIDEVQQAIGLNGAELLvkeLLNLIEYLTKEYHLCHVI 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966976278  175 GLTCRLDILELLEKRVKSRFSHRQIHLMnSFGFPQYVKIFKEQLSLPAEFPDKLFAEKWNE---NVQYLSE 242
Cdd:pfam01637 152 CLSSEGLFIELVYYKSPLIGRHRWALVD-PLDKETAWNFLKEGFKELYELSKEDFEEIWRYtggNPKYLEE 221
AAA_19 pfam13245
AAA domain;
37-85 5.17e-03

AAA domain;


Pssm-ID: 433059 [Multi-domain]  Cd Length: 136  Bit Score: 37.20  E-value: 5.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 966976278   37 RTALHgESNSVLIIGPrGSGKTMLINHALKELMEIEEVSENVLQVHLNG 85
Cdd:pfam13245   6 RTALP-SKVVLLTGGP-GTGKTTTIRHIVALLVALGGVSFPILLAAPTG 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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