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Conserved domains on  [gi|955543215|ref|XP_014652562|]
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PREDICTED: zonadhesin [Ceratotherium simum simum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 797-949 3.76e-50

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 175.25  E-value: 3.76e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   797 CFVSGDPHYLTFDGRHFSFMGKCTYILAQPCGNLKEPFFRVTAKNEERGQEGVsCLSTVYVTLPETTVTLLKGRRTLVGG 876
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 955543215   877 QQVTLPAMPSKG-VFLAPSGR-FVELQTAFGLRVRWDGDQQLSVSVPSTYSSKLCGLCGNYDGDSSNDNQKPDGS 949
Cdd:pfam00094   80 QKVSLPYKSDGGeVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1182-1335 8.60e-49

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 171.40  E-value: 8.60e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  1182 CTVSGDPHYLTFDGALHHFMGTCTYVLTQLCRSRSLentFVVSATNEFRSGNLEVSYVKAVHVQVFNLRISLIKGYKVVL 1261
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD---FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1262 DGRRVALPVWPARGRVSIRPSG-SFILLYTDFGLQVRYDGNHLVQVTVPSTYAGRLCGLCGNYNNNSLDDILSSD 1335
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILGSGfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPD 152
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1570-1723 8.98e-43

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 154.07  E-value: 8.98e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  1570 CRISDDSHYISFDGTYHALKSTCTYVLVKVCHSTMDlpfFKISGKNGKREGQTPAFYLRQVNVDILDSLVTLQKGHRVLI 1649
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD---FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1650 NGTQVTLPSTSRIRGISVTARG-AYTVLSINIGVQVKFDGNGFLEIELPAAYYGKVCGMCGNFNGEEEDELMMPS 1723
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILGSGfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPD 152
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 384-546 6.47e-42

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


:

Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 151.75  E-value: 6.47e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   384 CDFEDDAhpFCDWTQASGDGGHWTRGSknVPLQGTGPFG--VSVNTEGHYIYLEAGKFsQAGQSSRLMSRPFCAPG-AIC 460
Cdd:pfam00629    1 CDFEDGN--LCGWTQDSSDDFDWERVS--GPSVKTGPSSdhTQGTGSGHFMYVDTSSG-APGQTARLLSPLLPPSRsPQC 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   461 VEFSYHMYGLGEGAkLKLLLGSPAGSSPTSLWHRLGSQGLDWLNTSITVPSgRQQPMQLILEAIRGTNTAFVIAVGFIFI 540
Cdd:pfam00629   76 LRFWYHMSGSGVGT-LRVYVRENGGTLDTLLWSISGDQGPSWKEARVTLSS-STQPFQVVFEGIRGGGSRGGIALDDISL 153


                   ....*.
gi 955543215   541 NHGTCR 546
Cdd:pfam00629  154 SSGPCP 159
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 49-213 4.43e-40

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


:

Pssm-ID: 99706  Cd Length: 157  Bit Score: 146.37  E-value: 4.43e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   49 CDFEDDskpLCDWTQVSTDDGDWARASRLSASGSTSPPGGYPDGEGYYLHMDSNTFPRGGAAGLRSPPIWE-QGPLCVHF 127
Cdd:cd06263     1 CDFEDG---LCGWTQDSTDDFDWTRVSGSTPSPGTPPDHTHGTGSGHYLYVESSSGREGQKARLLSPLLPPpRSSHCLSF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  128 AYHMFGLSRGaQLKLLLLmGTKGRRPKLLWKHMNTQSPSWVPTTVTVPAsgggPSSLPQLIFEGVRGSTAYLDIALDAVS 207
Cdd:cd06263    78 WYHMYGSGVG-TLNVYVR-EEGGGLGTLLWSASGGQGNQWQEAEVTLSA----SSKPFQVVFEGVRGSGSRGDIALDDIS 151


                  ....*.
gi 955543215  208 IRRGSC 213
Cdd:cd06263   152 LSPGPC 157
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1967-2121 1.51e-38

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 142.12  E-value: 1.51e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  1967 CSVFGDPHYRTFDRLSYRFQGRMTYTLVKTVDVLPDgvePLVVEGRNKMYPPFSSIFLQEIIVMVYGYTVQLQAELELVV 2046
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD---FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  2047 NNQKMAIPYKVNEhLRVTMRS---HRLYLITNFELVVSFDGRNNAVISLPSMYEGLVRGLCGNYDQNRKNEFMLPNGT 2121
Cdd:pfam00094   78 NGQKVSLPYKSDG-GEVEILGsgfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 222-376 2.69e-27

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


:

Pssm-ID: 99706  Cd Length: 157  Bit Score: 109.77  E-value: 2.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  222 CSFDTpnDLCGWSWIPTaSGAKWVQKKGSSGVLNVGPeDDFSSPGSGFYMLLDPKDAKPRQKCALLSPL---SRSSGCls 298
Cdd:cd06263     1 CDFED--GLCGWTQDST-DDFDWTRVSGSTPSPGTPP-DHTHGTGSGHYLYVESSSGREGQKARLLSPLlppPRSSHC-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  299 LSFQYTLHGRSPGaALNVYASVLGSIRKHTLF--SGHPRPNWQPVSVNY-TGQGQVQFTVVGVFGKIPEPAVAVDAISIA 375
Cdd:cd06263    75 LSFWYHMYGSGVG-TLNVYVREEGGGLGTLLWsaSGGQGNQWQEAEVTLsASSKPFQVVFEGVRGSGSRGDIALDDISLS 153


                  .
gi 955543215  376 P 376
Cdd:cd06263   154 P 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 990-1063 1.43e-20

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 87.78  E-value: 1.43e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 955543215    990 SGPEFCGQLVASHGAFEACLPHLRASSFFENCMFDMCNFQGLQLMLCAHMAALTETCQDAGYVVKPWRGPQFCP 1063
Cdd:smart00832    3 YACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1378-1449 3.72e-20

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 86.63  E-value: 3.72e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 955543215   1378 WNKNCDILMNPLGPFSQCHKVVPPHSSFTSCVYGQCGTKGDTLTLCRSLQAYASLCAQASQAP-AWRNSTFCP 1449
Cdd:smart00832    4 ACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCIsPWRTPTFCP 76
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2175-2250 4.55e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 83.54  E-value: 4.55e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 955543215   2175 STQACRVLMDSQGPFATCHQTVAPEPFHEHCVFDLCAAQDprqREELRCQVLSGYAIICQEAGTALASWRDYTRCA 2250
Cdd:smart00832    4 ACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGG---DCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1906-1960 5.50e-15

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


:

Pssm-ID: 432736  Cd Length: 54  Bit Score: 71.18  E-value: 5.50e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1906 CKDAQGGSLPAGKTWLSRGCTHRCACRAGAIQCGPFTCPSGSHCQPNStSTDNCA 1960
Cdd:pfam12714    1 CKDAQGNYIPAGKTWFSSGCTQSCTCTGGNIQCQPFQCPPGTVCKDND-GSSNCH 54
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 486-690 1.06e-14

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 80.35  E-value: 1.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   486 SSPTslwhrLGSQGLDWLNTSITVPSGRQQPMQLILEAIRG--TNTAFVIAVgfifINHGTCRGPAPtVLPSKSPVPLTG 563
Cdd:pfam05109  430 TSPT-----LNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGptVSTADVTSP----TPAGTTSGASP-VTPSPSPRDNGT 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   564 PSETPVFTgkplATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******TERTTVPTEKPTIPTEKPAVPTEKPTAPTTP 643
Cdd:pfam05109  500 ESKAPDMT----SPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLG 575

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 955543215   644 QPSPTLVPTRPAVSVMPP----SAPSTSMTTVSLATTAAPrPTPASCPPNA 690
Cdd:pfam05109  576 KTSPTSAVTTPTPNATSPtvgeTSPQANTTNHTLGGTSST-PVVTSPPKNA 625
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1066-1119 4.78e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.50  E-value: 4.78e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215 1066 CPPNSNYTLCARPCPDTCHSSFSGMACQDRCVEGCECNPGFVLS-GLQCVPQSQC 1119
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1509-1563 8.61e-14

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


:

Pssm-ID: 432736  Cd Length: 54  Bit Score: 67.71  E-value: 8.61e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1509 CTDQRGSYHPVGESWYTDNtCSRLCSCSTHNISCLPSACKPGQMCWPLDGLMRCR 1563
Cdd:pfam12714    1 CKDAQGNYIPAGKTWFSSG-CTQSCTCTGGNIQCQPFQCPPGTVCKDNDGSSNCH 54
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 2253-2306 1.13e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


:

Pssm-ID: 460351  Cd Length: 55  Bit Score: 64.72  E-value: 1.13e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  2253 CPANTVYQSCMTPCPPSCANLAAPGDCEGPCVEGCASLPGYIYS-GAQSLPLAHC 2306
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 737-790 2.50e-12

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


:

Pssm-ID: 432736  Cd Length: 54  Bit Score: 63.48  E-value: 2.50e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 955543215   737 CVYNNNYYKPGVEWFSPNCTERCRCwPGSRMECQLSRCAIHTVCQLKDGQYGCH 790
Cdd:pfam12714    2 KDAQGNYIPAGKTWFSSGCTQSCTC-TGGNIQCQPFQCPPGTVCKDNDGSSNCH 54
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1452-1507 4.27e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


:

Pssm-ID: 460351  Cd Length: 55  Bit Score: 62.79  E-value: 4.27e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 955543215  1452 CPSGSSYSSCANPCPATCLSLTTPRDCPAalPCAEGCECQKGHVLS-GTSCVPLSQC 1507
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPE--PCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 686-735 4.33e-11

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


:

Pssm-ID: 460351  Cd Length: 55  Bit Score: 60.09  E-value: 4.33e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215   686 CPPNAHYEPC--ACPASCESPKPT--CELVCQPGCVCNPGFLFN-DSRCVDASSC 735
Cdd:pfam01826    1 CPANEVYSECgsACPPTCANLSPPdvCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1121-1175 7.50e-11

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


:

Pssm-ID: 432736  Cd Length: 54  Bit Score: 59.24  E-value: 7.50e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1121 CLDPRAGYFKIGEQWFKPGCTQLCICEGsNRIRCVLWRCQAQEVCALQDGVYGCH 1175
Cdd:pfam12714    1 CKDAQGNYIPAGKTWFSSGCTQSCTCTG-GNIQCQPFQCPPGTVCKDNDGSSNCH 54
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1848-1904 6.37e-10

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


:

Pssm-ID: 460351  Cd Length: 55  Bit Score: 56.63  E-value: 6.37e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  1848 CPAFSTYTTCIPSCSLSCGDPEgqcKGTEVPATCKEGCVCLPGYVLS-EQRCVPRSQC 1904
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLS---PPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1777-1844 1.55e-09

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 56.23  E-value: 1.55e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  1777 QCQAAFQAPAWAECATRVVLKPFLLGCTYKLCEFGGLNRVLCESVQAFGAACKAQGLKPPIWRNSSFC 1844
Cdd:pfam08742    1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 2308-2361 4.39e-09

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam12714:

Pssm-ID: 450195  Cd Length: 54  Bit Score: 54.23  E-value: 4.39e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 955543215  2308 CTHNGIYYQQGDSFVTEDCSQRCTCASlGVLLCEPLSCGAGEICTLGNLTRGCF 2361
Cdd:pfam12714    2 KDAQGNYIPAGKTWFSSGCTQSCTCTG-GNIQCQPFQCPPGTVCKDNDGSSNCH 54
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2366-2395 3.35e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.35e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 955543215  2366 CLRNPCQNDGRCQEQGPYFTCECELGYGGD 2395
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 797-949 3.76e-50

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 175.25  E-value: 3.76e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   797 CFVSGDPHYLTFDGRHFSFMGKCTYILAQPCGNLKEPFFRVTAKNEERGQEGVsCLSTVYVTLPETTVTLLKGRRTLVGG 876
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 955543215   877 QQVTLPAMPSKG-VFLAPSGR-FVELQTAFGLRVRWDGDQQLSVSVPSTYSSKLCGLCGNYDGDSSNDNQKPDGS 949
Cdd:pfam00094   80 QKVSLPYKSDGGeVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1182-1335 8.60e-49

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 171.40  E-value: 8.60e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  1182 CTVSGDPHYLTFDGALHHFMGTCTYVLTQLCRSRSLentFVVSATNEFRSGNLEVSYVKAVHVQVFNLRISLIKGYKVVL 1261
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD---FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1262 DGRRVALPVWPARGRVSIRPSG-SFILLYTDFGLQVRYDGNHLVQVTVPSTYAGRLCGLCGNYNNNSLDDILSSD 1335
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILGSGfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPD 152
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1174-1335 9.80e-45

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 159.87  E-value: 9.80e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   1174 CHAQGTATCTVSGDPHYLTFDGALHHFMGTCTYVLTQLCRSrslENTFVVSATNEFRSGNLEVsyVKAVHVQVFNLRISL 1253
Cdd:smart00216    4 TQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSS---EPTFSVLLKNVPCGGGATC--LKSVKVELNGDEIEL 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   1254 IKGY-KVVLDGRRVALPVWPARGRVSIRPSGSFILLYTDFGL-QVRYDGNHLVQVTVPSTYAGRLCGLCGNYNNNSLDDI 1331
Cdd:smart00216   79 KDDNgKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....
gi 955543215   1332 LSSD 1335
Cdd:smart00216  159 RTPD 162
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 789-948 7.72e-43

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 154.48  E-value: 7.72e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    789 CHPYGtATCFVSGDPHYLTFDGRHFSFMGKCTYILAQPCGNlkEPFFRVTAKNEERGQeGVSCLSTVYVTLPETTVTLLK 868
Cdd:smart00216    5 QEECS-PTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSS--EPTFSVLLKNVPCGG-GATCLKSVKVELNGDEIELKD 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    869 GRRT-LVGGQQVTLPAMPS-KGVFLAPSGRFVELQTAFGL-RVRWDGDQQLSVSVPSTYSSKLCGLCGNYDGDSSNDNQK 945
Cdd:smart00216   81 DNGKvTVNGQQVSLPYKTSdGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRT 160


                    ...
gi 955543215    946 PDG 948
Cdd:smart00216  161 PDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1570-1723 8.98e-43

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 154.07  E-value: 8.98e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  1570 CRISDDSHYISFDGTYHALKSTCTYVLVKVCHSTMDlpfFKISGKNGKREGQTPAFYLRQVNVDILDSLVTLQKGHRVLI 1649
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD---FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1650 NGTQVTLPSTSRIRGISVTARG-AYTVLSINIGVQVKFDGNGFLEIELPAAYYGKVCGMCGNFNGEEEDELMMPS 1723
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILGSGfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPD 152
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 384-546 6.47e-42

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 151.75  E-value: 6.47e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   384 CDFEDDAhpFCDWTQASGDGGHWTRGSknVPLQGTGPFG--VSVNTEGHYIYLEAGKFsQAGQSSRLMSRPFCAPG-AIC 460
Cdd:pfam00629    1 CDFEDGN--LCGWTQDSSDDFDWERVS--GPSVKTGPSSdhTQGTGSGHFMYVDTSSG-APGQTARLLSPLLPPSRsPQC 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   461 VEFSYHMYGLGEGAkLKLLLGSPAGSSPTSLWHRLGSQGLDWLNTSITVPSgRQQPMQLILEAIRGTNTAFVIAVGFIFI 540
Cdd:pfam00629   76 LRFWYHMSGSGVGT-LRVYVRENGGTLDTLLWSISGDQGPSWKEARVTLSS-STQPFQVVFEGIRGGGSRGGIALDDISL 153


                   ....*.
gi 955543215   541 NHGTCR 546
Cdd:pfam00629  154 SSGPCP 159
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 49-213 4.43e-40

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 146.37  E-value: 4.43e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   49 CDFEDDskpLCDWTQVSTDDGDWARASRLSASGSTSPPGGYPDGEGYYLHMDSNTFPRGGAAGLRSPPIWE-QGPLCVHF 127
Cdd:cd06263     1 CDFEDG---LCGWTQDSTDDFDWTRVSGSTPSPGTPPDHTHGTGSGHYLYVESSSGREGQKARLLSPLLPPpRSSHCLSF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  128 AYHMFGLSRGaQLKLLLLmGTKGRRPKLLWKHMNTQSPSWVPTTVTVPAsgggPSSLPQLIFEGVRGSTAYLDIALDAVS 207
Cdd:cd06263    78 WYHMYGSGVG-TLNVYVR-EEGGGLGTLLWSASGGQGNQWQEAEVTLSA----SSKPFQVVFEGVRGSGSRGDIALDDIS 151


                  ....*.
gi 955543215  208 IRRGSC 213
Cdd:cd06263   152 LSPGPC 157
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
 380-545 5.72e-40

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 146.33  E-value: 5.72e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    380 SFPQCDFEDDahPFCDWTQASGDGGHWTRGSKNVPlqGTGPFGVSVNTEGHYIYLEAGKFSQaGQSSRLMSRPFCAP-GA 458
Cdd:smart00137    2 SPGNCDFEEG--STCGWHQDSNDDGHWERVSSATG--IPGPNRDHTTGNGHFMFFETSSGAE-GQTARLLSPPLYENrST 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    459 ICVEFSYHMYGLGEGAkLKLLLGSPAGSSPTSLWHRLGSQGLDWLNTSITVPSgRQQPMQLILEAIRGTNTAFVIAVGFI 538
Cdd:smart00137   77 HCLTFWYYMYGSGSGT-LNVYVRENNGSQDTLLWSRSGTQGGQWLQAEVALSS-WPQPFQVVFEGTRGKGHSGYIALDDI 154


                    ....*..
gi 955543215    539 FINHGTC 545
Cdd:smart00137  155 LLSNGPC 161
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1967-2121 1.51e-38

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 142.12  E-value: 1.51e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  1967 CSVFGDPHYRTFDRLSYRFQGRMTYTLVKTVDVLPDgvePLVVEGRNKMYPPFSSIFLQEIIVMVYGYTVQLQAELELVV 2046
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD---FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  2047 NNQKMAIPYKVNEhLRVTMRS---HRLYLITNFELVVSFDGRNNAVISLPSMYEGLVRGLCGNYDQNRKNEFMLPNGT 2121
Cdd:pfam00094   78 NGQKVSLPYKSDG-GEVEILGsgfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 384-545 1.50e-37

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 139.44  E-value: 1.50e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  384 CDFEDDahpFCDWTQASGDGGHWTRGSKNVPLQGTGPFGVSVNTEGHYIYLEAGkFSQAGQSSRLMSRPFCAP-GAICVE 462
Cdd:cd06263     1 CDFEDG---LCGWTQDSTDDFDWTRVSGSTPSPGTPPDHTHGTGSGHYLYVESS-SGREGQKARLLSPLLPPPrSSHCLS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  463 FSYHMYGLGEGaKLKLLLGSPAGSSPTSLWHRLGSQGLDWLNTSITVPSgRQQPMQLILEAIRGTNTAFVIAVGFIFINH 542
Cdd:cd06263    77 FWYHMYGSGVG-TLNVYVREEGGGLGTLLWSASGGQGNQWQEAEVTLSA-SSKPFQVVFEGVRGSGSRGDIALDDISLSP 154


                  ...
gi 955543215  543 GTC 545
Cdd:cd06263   155 GPC 157
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1570-1723 4.22e-36

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 135.22  E-value: 4.22e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   1570 CRISDDSHYISFDGTYHALKSTCTYVLVKVCHSTmdlPFFKISGKNGKREGQtpAFYLRQVNVDILDSLVTLQKGHR-VL 1648
Cdd:smart00216   12 CSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSE---PTFSVLLKNVPCGGG--ATCLKSVKVELNGDEIELKDDNGkVT 86

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 955543215   1649 INGTQVTLPSTSRIRGISVTARGAYTVLSINIGV-QVKFDGNGFLEIELPAAYYGKVCGMCGNFNGEEEDELMMPS 1723
Cdd:smart00216   87 VNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPD 162
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1967-2120 2.66e-33

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 127.13  E-value: 2.66e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   1967 CSVFGDPHYRTFDRLSYRFQGRMTYTLVKTVDVLPDgvepLVVEGRNKMYPPFSSIfLQEIIVMVYGYTVQL-QAELELV 2045
Cdd:smart00216   12 CSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPT----FSVLLKNVPCGGGATC-LKSVKVELNGDEIELkDDNGKVT 86

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 955543215   2046 VNNQKMAIPYKVNE-HLRVTMRSHRLYLITNFELV-VSFDGRNNAVISLPSMYEGLVRGLCGNYDQNRKNEFMLPNG 2120
Cdd:smart00216   87 VNGQQVSLPYKTSDgSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPDG 163
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 49-214 7.51e-32

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 122.86  E-value: 7.51e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    49 CDFEDDSkpLCDWTQVSTDDGDWARASRLSASgsTSPPGG--YPDGEGYYLHMDSNTFPRGGAAGLRSPPIWEQG-PLCV 125
Cdd:pfam00629    1 CDFEDGN--LCGWTQDSSDDFDWERVSGPSVK--TGPSSDhtQGTGSGHFMYVDTSSGAPGQTARLLSPLLPPSRsPQCL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   126 HFAYHMFGLSRGaQLKLLLLMgTKGRRPKLLWKHMNTQSPSWVPTTVTVPASgggpSSLPQLIFEGVRGSTAYLDIALDA 205
Cdd:pfam00629   77 RFWYHMSGSGVG-TLRVYVRE-NGGTLDTLLWSISGDQGPSWKEARVTLSSS----TQPFQVVFEGIRGGGSRGGIALDD 150


                   ....*....
gi 955543215   206 VSIRRGSCN 214
Cdd:pfam00629  151 ISLSSGPCP 159
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
 48-213 1.82e-28

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 113.21  E-value: 1.82e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215     48 HCDFEDDskPLCDWTQVSTDDGDWARASrlSASGSTSPPGGYPDGEGYYLHMDSNTFPRGGAAGLRSPPIWEQ-GPLCVH 126
Cdd:smart00137    5 NCDFEEG--STCGWHQDSNDDGHWERVS--SATGIPGPNRDHTTGNGHFMFFETSSGAEGQTARLLSPPLYENrSTHCLT 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    127 FAYHMFGLSRGA-QLKLLLLMGTKgrrPKLLWKHMNTQSPSWVPTTVTVPasgggPSSLP-QLIFEGVRGSTAYLDIALD 204
Cdd:smart00137   81 FWYYMYGSGSGTlNVYVRENNGSQ---DTLLWSRSGTQGGQWLQAEVALS-----SWPQPfQVVFEGTRGKGHSGYIALD 152


                    ....*....
gi 955543215    205 AVSIRRGSC 213
Cdd:smart00137  153 DILLSNGPC 161
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 222-376 2.69e-27

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 109.77  E-value: 2.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  222 CSFDTpnDLCGWSWIPTaSGAKWVQKKGSSGVLNVGPeDDFSSPGSGFYMLLDPKDAKPRQKCALLSPL---SRSSGCls 298
Cdd:cd06263     1 CDFED--GLCGWTQDST-DDFDWTRVSGSTPSPGTPP-DHTHGTGSGHYLYVESSSGREGQKARLLSPLlppPRSSHC-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  299 LSFQYTLHGRSPGaALNVYASVLGSIRKHTLF--SGHPRPNWQPVSVNY-TGQGQVQFTVVGVFGKIPEPAVAVDAISIA 375
Cdd:cd06263    75 LSFWYHMYGSGVG-TLNVYVREEGGGLGTLLWsaSGGQGNQWQEAEVTLsASSKPFQVVFEGVRGSGSRGDIALDDISLS 153


                  .
gi 955543215  376 P 376
Cdd:cd06263   154 P 154
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 222-378 1.29e-24

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 102.44  E-value: 1.29e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   222 CSFDTPNdLCGWsWIPTASGAKWVQKKGSSgvLNVGPEDDFS-SPGSGFYMLLDPKDAKPRQKCALLSPL---SRSSGCl 297
Cdd:pfam00629    1 CDFEDGN-LCGW-TQDSSDDFDWERVSGPS--VKTGPSSDHTqGTGSGHFMYVDTSSGAPGQTARLLSPLlppSRSPQC- 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   298 sLSFQYTLHGRSPGaALNVYASVLGSIRKHTLFS--GHPRPNWQPVSVNYTGQG---QVQFtvVGVFGKIPEPAVAVDAI 372
Cdd:pfam00629   76 -LRFWYHMSGSGVG-TLRVYVRENGGTLDTLLWSisGDQGPSWKEARVTLSSSTqpfQVVF--EGIRGGGSRGGIALDDI 151


                   ....*...
gi 955543215   373 SIA--PCG 378
Cdd:pfam00629  152 SLSsgPCP 159
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 990-1063 1.43e-20

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 87.78  E-value: 1.43e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 955543215    990 SGPEFCGQLVASHGAFEACLPHLRASSFFENCMFDMCNFQGLQLMLCAHMAALTETCQDAGYVVKPWRGPQFCP 1063
Cdd:smart00832    3 YACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1378-1449 3.72e-20

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 86.63  E-value: 3.72e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 955543215   1378 WNKNCDILMNPLGPFSQCHKVVPPHSSFTSCVYGQCGTKGDTLTLCRSLQAYASLCAQASQAP-AWRNSTFCP 1449
Cdd:smart00832    4 ACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCIsPWRTPTFCP 76
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2175-2250 4.55e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 83.54  E-value: 4.55e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 955543215   2175 STQACRVLMDSQGPFATCHQTVAPEPFHEHCVFDLCAAQDprqREELRCQVLSGYAIICQEAGTALASWRDYTRCA 2250
Cdd:smart00832    4 ACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGG---DCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1382-1448 1.44e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.18  E-value: 1.44e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  1382 CDILMNPlGPFSQCHKVVPPHSSFTSCVYGQCGTKGDTLTLCRSLQAYASLCAQASQAPA-WRNSTFC 1448
Cdd:pfam08742    2 CGLLSDS-GPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGdWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 994-1062 2.04e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 72.80  E-value: 2.04e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 955543215   994 FCGQLVAShGAFEACLPHLRASSFFENCMFDMCNFQGLQLMLCAHMAALTETCQDAGYVVKPWRGPQFC 1062
Cdd:pfam08742    1 KCGLLSDS-GPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 2179-2249 2.34e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 72.41  E-value: 2.34e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 955543215  2179 CRVLMDSqGPFATCHQTVAPEPFHEHCVFDLCAAQDPRqreELRCQVLSGYAIICQEAGTALASWRDYTRC 2249
Cdd:pfam08742    2 CGLLSDS-GPFAPCHSVVDPEPYFEACVYDMCSCGGDD---ECLCAALAAYARACQAAGVCIGDWRTPTFC 68
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
 222-377 3.48e-15

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 75.46  E-value: 3.48e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    222 CSFDTPNdLCGWSWIpTASGAKWVQkkGSSGVLNVGPEDDfSSPGSGFYMLLDPKDAKPRQKCALLSPLSRS--SGClSL 299
Cdd:smart00137    6 CDFEEGS-TCGWHQD-SNDDGHWER--VSSATGIPGPNRD-HTTGNGHFMFFETSSGAEGQTARLLSPPLYEnrSTH-CL 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    300 SFQYTLHGrSPGAALNVYASVLGSIRKHTLF--SGHPRPNWQPVSVNY-TGQGQVQFTVVGVFGKIPEPAVAVDAISIA- 375
Cdd:smart00137   80 TFWYYMYG-SGSGTLNVYVRENNGSQDTLLWsrSGTQGGQWLQAEVALsSWPQPFQVVFEGTRGKGHSGYIALDDILLSn 158


                    ...
gi 955543215    376 -PC 377
Cdd:smart00137  159 gPC 161
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1906-1960 5.50e-15

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 71.18  E-value: 5.50e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1906 CKDAQGGSLPAGKTWLSRGCTHRCACRAGAIQCGPFTCPSGSHCQPNStSTDNCA 1960
Cdd:pfam12714    1 CKDAQGNYIPAGKTWFSSGCTQSCTCTGGNIQCQPFQCPPGTVCKDND-GSSNCH 54
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 486-690 1.06e-14

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 80.35  E-value: 1.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   486 SSPTslwhrLGSQGLDWLNTSITVPSGRQQPMQLILEAIRG--TNTAFVIAVgfifINHGTCRGPAPtVLPSKSPVPLTG 563
Cdd:pfam05109  430 TSPT-----LNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGptVSTADVTSP----TPAGTTSGASP-VTPSPSPRDNGT 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   564 PSETPVFTgkplATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******TERTTVPTEKPTIPTEKPAVPTEKPTAPTTP 643
Cdd:pfam05109  500 ESKAPDMT----SPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLG 575

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 955543215   644 QPSPTLVPTRPAVSVMPP----SAPSTSMTTVSLATTAAPrPTPASCPPNA 690
Cdd:pfam05109  576 KTSPTSAVTTPTPNATSPtvgeTSPQANTTNHTLGGTSST-PVVTSPPKNA 625
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1066-1119 4.78e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.50  E-value: 4.78e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215 1066 CPPNSNYTLCARPCPDTCHSSFSGMACQDRCVEGCECNPGFVLS-GLQCVPQSQC 1119
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1509-1563 8.61e-14

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 67.71  E-value: 8.61e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1509 CTDQRGSYHPVGESWYTDNtCSRLCSCSTHNISCLPSACKPGQMCWPLDGLMRCR 1563
Cdd:pfam12714    1 CKDAQGNYIPAGKTWFSSG-CTQSCTCTGGNIQCQPFQCPPGTVCKDNDGSSNCH 54
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1066-1119 3.83e-13

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 65.87  E-value: 3.83e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1066 CPPNSNYTLCARPCPDTCHSSFSGMACQDRCVEGCECNPGFVLSGL-QCVPQSQC 1119
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNSGgKCVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 2253-2306 1.13e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 64.72  E-value: 1.13e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  2253 CPANTVYQSCMTPCPPSCANLAAPGDCEGPCVEGCASLPGYIYS-GAQSLPLAHC 2306
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 737-790 2.50e-12

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 63.48  E-value: 2.50e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 955543215   737 CVYNNNYYKPGVEWFSPNCTERCRCwPGSRMECQLSRCAIHTVCQLKDGQYGCH 790
Cdd:pfam12714    2 KDAQGNYIPAGKTWFSSGCTQSCTC-TGGNIQCQPFQCPPGTVCKDNDGSSNCH 54
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1452-1507 4.27e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 62.79  E-value: 4.27e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 955543215  1452 CPSGSSYSSCANPCPATCLSLTTPRDCPAalPCAEGCECQKGHVLS-GTSCVPLSQC 1507
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPE--PCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1452-1507 6.38e-12

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 62.33  E-value: 6.38e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 955543215 1452 CPSGSSYSSCANPCPATCLSLTTPRDCPAalPCAEGCECQKGHVLS-GTSCVPLSQC 1507
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTK--QCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 686-735 4.33e-11

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 60.09  E-value: 4.33e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215   686 CPPNAHYEPC--ACPASCESPKPT--CELVCQPGCVCNPGFLFN-DSRCVDASSC 735
Cdd:pfam01826    1 CPANEVYSECgsACPPTCANLSPPdvCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1121-1175 7.50e-11

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 59.24  E-value: 7.50e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1121 CLDPRAGYFKIGEQWFKPGCTQLCICEGsNRIRCVLWRCQAQEVCALQDGVYGCH 1175
Cdd:pfam12714    1 CKDAQGNYIPAGKTWFSSGCTQSCTCTG-GNIQCQPFQCPPGTVCKDNDGSSNCH 54
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 686-735 1.07e-10

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 58.87  E-value: 1.07e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  686 CPPNAHYEPC--ACPASCESPK--PTCELVCQPGCVCNPGFLFN-DSRCVDASSC 735
Cdd:cd19941     1 CPPNEVYSECgsACPPTCANPNapPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 2253-2296 1.09e-10

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 58.87  E-value: 1.09e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 955543215 2253 CPANTVYQSCMTPCPPSCANLAAPGDCEGPCVEGCASLPGYIYS 2296
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRN 44
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-694 5.09e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.73  E-value: 5.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  548 PAPTVLPSKSPVPlTGPSETPVFTG-------------KPLATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******TE 614
Cdd:PHA03247 2830 PPTSAQPTAPPPP-PGPPPPSLPLGgsvapggdvrrrpPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERP 2908

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  615 RTTVPTEKPTIPTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMPPS-----------APSTSMTTVSLATTAAP-RPT 682
Cdd:PHA03247 2909 PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSgavpqpwlgalVPGRVAVPRFRVPQPAPsREA 2988

                         170
                  ....*....|..
gi 955543215  683 PASCPPNAHYEP 694
Cdd:PHA03247 2989 PASSTPPLTGHS 3000
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1848-1904 6.37e-10

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 56.63  E-value: 6.37e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  1848 CPAFSTYTTCIPSCSLSCGDPEgqcKGTEVPATCKEGCVCLPGYVLS-EQRCVPRSQC 1904
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLS---PPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1777-1844 1.55e-09

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 56.23  E-value: 1.55e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  1777 QCQAAFQAPAWAECATRVVLKPFLLGCTYKLCEFGGLNRVLCESVQAFGAACKAQGLKPPIWRNSSFC 1844
Cdd:pfam08742    1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1848-1904 2.23e-09

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 55.02  E-value: 2.23e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215 1848 CPAFSTYTTCIPSCSLSCGDPEGQ--CkgtevPATCKEGCVCLPGYVLSEQ-RCVPRSQC 1904
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPppC-----TKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 2308-2361 4.39e-09

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 54.23  E-value: 4.39e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 955543215  2308 CTHNGIYYQQGDSFVTEDCSQRCTCASlGVLLCEPLSCGAGEICTLGNLTRGCF 2361
Cdd:pfam12714    2 KDAQGNYIPAGKTWFSSGCTQSCTCTG-GNIQCQPFQCPPGTVCKDNDGSSNCH 54
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1788-1845 2.08e-08

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 53.11  E-value: 2.08e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215   1788 AECATRVVLKPFLLGCTYKLCEFGGLNRVLCESVQAFGAACKAQGLKPPIWRNSSFCP 1845
Cdd:smart00832   19 AACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 534-715 1.58e-07

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 56.70  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  534 AVGFIFINHGTCRGPAPTVLPSKS-PVPLTGPS-ETPVFTGKPLATTEKPTVpteKPTVSTEKPTVPTE----NPTIPT* 607
Cdd:NF033839  270 AVVTKFKKGLTQDTPKEPGNKKPSaPKPGMQPSpQPEKKEVKPEPETPKPEV---KPQLEKPKPEVKPQpekpKPEVKPQ 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  608 *****TE-----RTTVPTEKPTIPTEKPAVP----TEKPTA---PTTPQPSPTLVPTRPAVSVMP-PSAPSTSMTTVSLA 674
Cdd:NF033839  347 LETPKPEvkpqpEKPKPEVKPQPEKPKPEVKpqpeTPKPEVkpqPEKPKPEVKPQPEKPKPEVKPqPEKPKPEVKPQPEK 426

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 955543215  675 TTAAPRPTPASCPPNAHYEPcacpascESPKPtcELVCQPG 715
Cdd:NF033839  427 PKPEVKPQPEKPKPEVKPQP-------EKPKP--EVKPQPE 458
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 547-706 8.30e-07

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 54.39  E-value: 8.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  547 GPAPTVLPS-KSPVPLTGPS-ETPVFTGKPLATTEKPTVpteKPTVSTEKPTVPTEnPTIPT******TErTTVPTEKPT 624
Cdd:NF033839  338 KPKPEVKPQlETPKPEVKPQpEKPKPEVKPQPEKPKPEV---KPQPETPKPEVKPQ-PEKPKPEVKPQPE-KPKPEVKPQ 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  625 IPTEKPAVPT--EKPT-----APTTPQPSPTLVPTRPAVSVMP-PSAPSTSMttvslattaapRPTPASCPPNAHYEPca 696
Cdd:NF033839  413 PEKPKPEVKPqpEKPKpevkpQPEKPKPEVKPQPEKPKPEVKPqPETPKPEV-----------KPQPEKPKPEVKPQP-- 479

                         170
                  ....*....|
gi 955543215  697 cpascESPKP 706
Cdd:NF033839  480 -----EKPKP 484
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
2308-2371 1.57e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 47.56  E-value: 1.57e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 955543215   2308 CTHNGIYYQQGDSFVtEDCsQRCTCASlGVLLCEPLSCGAGEiCTLGNLTRGCFRESP-------CLRNPC 2371
Cdd:smart00215    1 CWNNGSYYPPGAKWD-DDC-NRCTCLN-GRVSCTKVWCGPKP-CLLHNLSGECPLGQGcvpslsdCLSSPC 67
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 572-694 4.67e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 48.84  E-value: 4.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   572 GKPLATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******--------TERTTVPTEKPTIPTEKPAV--PTEKPTAPT 641
Cdd:TIGR00927  302 GKNNLTTPQGTVLEHTPATSEGQVTISIMTGSSPAETKASTaawkirnpLSRTSAPAVRIASATFRGLEknPSTAPSTPA 381

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 955543215   642 TPQ--PSPTlVPTRPAVSVMP----PSAPSTSMTTVSLATTAAPRPT--PASCP---PNAHYEP 694
Cdd:TIGR00927  382 TPRvrAVLT-TQVHHCVVVKPapavPTTPSPSLTTALFPEAPSPSPSalPPGQPdlhPKAEYPP 444
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2366-2395 3.35e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.35e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 955543215  2366 CLRNPCQNDGRCQEQGPYFTCECELGYGGD 2395
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 797-949 3.76e-50

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 175.25  E-value: 3.76e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   797 CFVSGDPHYLTFDGRHFSFMGKCTYILAQPCGNLKEPFFRVTAKNEERGQEGVsCLSTVYVTLPETTVTLLKGRRTLVGG 876
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 955543215   877 QQVTLPAMPSKG-VFLAPSGR-FVELQTAFGLRVRWDGDQQLSVSVPSTYSSKLCGLCGNYDGDSSNDNQKPDGS 949
Cdd:pfam00094   80 QKVSLPYKSDGGeVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1182-1335 8.60e-49

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 171.40  E-value: 8.60e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  1182 CTVSGDPHYLTFDGALHHFMGTCTYVLTQLCRSRSLentFVVSATNEFRSGNLEVSYVKAVHVQVFNLRISLIKGYKVVL 1261
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD---FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1262 DGRRVALPVWPARGRVSIRPSG-SFILLYTDFGLQVRYDGNHLVQVTVPSTYAGRLCGLCGNYNNNSLDDILSSD 1335
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILGSGfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPD 152
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1174-1335 9.80e-45

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 159.87  E-value: 9.80e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   1174 CHAQGTATCTVSGDPHYLTFDGALHHFMGTCTYVLTQLCRSrslENTFVVSATNEFRSGNLEVsyVKAVHVQVFNLRISL 1253
Cdd:smart00216    4 TQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSS---EPTFSVLLKNVPCGGGATC--LKSVKVELNGDEIEL 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   1254 IKGY-KVVLDGRRVALPVWPARGRVSIRPSGSFILLYTDFGL-QVRYDGNHLVQVTVPSTYAGRLCGLCGNYNNNSLDDI 1331
Cdd:smart00216   79 KDDNgKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....
gi 955543215   1332 LSSD 1335
Cdd:smart00216  159 RTPD 162
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 789-948 7.72e-43

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 154.48  E-value: 7.72e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    789 CHPYGtATCFVSGDPHYLTFDGRHFSFMGKCTYILAQPCGNlkEPFFRVTAKNEERGQeGVSCLSTVYVTLPETTVTLLK 868
Cdd:smart00216    5 QEECS-PTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSS--EPTFSVLLKNVPCGG-GATCLKSVKVELNGDEIELKD 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    869 GRRT-LVGGQQVTLPAMPS-KGVFLAPSGRFVELQTAFGL-RVRWDGDQQLSVSVPSTYSSKLCGLCGNYDGDSSNDNQK 945
Cdd:smart00216   81 DNGKvTVNGQQVSLPYKTSdGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRT 160


                    ...
gi 955543215    946 PDG 948
Cdd:smart00216  161 PDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1570-1723 8.98e-43

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 154.07  E-value: 8.98e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  1570 CRISDDSHYISFDGTYHALKSTCTYVLVKVCHSTMDlpfFKISGKNGKREGQTPAFYLRQVNVDILDSLVTLQKGHRVLI 1649
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD---FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1650 NGTQVTLPSTSRIRGISVTARG-AYTVLSINIGVQVKFDGNGFLEIELPAAYYGKVCGMCGNFNGEEEDELMMPS 1723
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILGSGfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPD 152
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 384-546 6.47e-42

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 151.75  E-value: 6.47e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   384 CDFEDDAhpFCDWTQASGDGGHWTRGSknVPLQGTGPFG--VSVNTEGHYIYLEAGKFsQAGQSSRLMSRPFCAPG-AIC 460
Cdd:pfam00629    1 CDFEDGN--LCGWTQDSSDDFDWERVS--GPSVKTGPSSdhTQGTGSGHFMYVDTSSG-APGQTARLLSPLLPPSRsPQC 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   461 VEFSYHMYGLGEGAkLKLLLGSPAGSSPTSLWHRLGSQGLDWLNTSITVPSgRQQPMQLILEAIRGTNTAFVIAVGFIFI 540
Cdd:pfam00629   76 LRFWYHMSGSGVGT-LRVYVRENGGTLDTLLWSISGDQGPSWKEARVTLSS-STQPFQVVFEGIRGGGSRGGIALDDISL 153


                   ....*.
gi 955543215   541 NHGTCR 546
Cdd:pfam00629  154 SSGPCP 159
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 49-213 4.43e-40

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 146.37  E-value: 4.43e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   49 CDFEDDskpLCDWTQVSTDDGDWARASRLSASGSTSPPGGYPDGEGYYLHMDSNTFPRGGAAGLRSPPIWE-QGPLCVHF 127
Cdd:cd06263     1 CDFEDG---LCGWTQDSTDDFDWTRVSGSTPSPGTPPDHTHGTGSGHYLYVESSSGREGQKARLLSPLLPPpRSSHCLSF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  128 AYHMFGLSRGaQLKLLLLmGTKGRRPKLLWKHMNTQSPSWVPTTVTVPAsgggPSSLPQLIFEGVRGSTAYLDIALDAVS 207
Cdd:cd06263    78 WYHMYGSGVG-TLNVYVR-EEGGGLGTLLWSASGGQGNQWQEAEVTLSA----SSKPFQVVFEGVRGSGSRGDIALDDIS 151


                  ....*.
gi 955543215  208 IRRGSC 213
Cdd:cd06263   152 LSPGPC 157
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
 380-545 5.72e-40

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 146.33  E-value: 5.72e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    380 SFPQCDFEDDahPFCDWTQASGDGGHWTRGSKNVPlqGTGPFGVSVNTEGHYIYLEAGKFSQaGQSSRLMSRPFCAP-GA 458
Cdd:smart00137    2 SPGNCDFEEG--STCGWHQDSNDDGHWERVSSATG--IPGPNRDHTTGNGHFMFFETSSGAE-GQTARLLSPPLYENrST 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    459 ICVEFSYHMYGLGEGAkLKLLLGSPAGSSPTSLWHRLGSQGLDWLNTSITVPSgRQQPMQLILEAIRGTNTAFVIAVGFI 538
Cdd:smart00137   77 HCLTFWYYMYGSGSGT-LNVYVRENNGSQDTLLWSRSGTQGGQWLQAEVALSS-WPQPFQVVFEGTRGKGHSGYIALDDI 154


                    ....*..
gi 955543215    539 FINHGTC 545
Cdd:smart00137  155 LLSNGPC 161
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1967-2121 1.51e-38

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 142.12  E-value: 1.51e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  1967 CSVFGDPHYRTFDRLSYRFQGRMTYTLVKTVDVLPDgvePLVVEGRNKMYPPFSSIFLQEIIVMVYGYTVQLQAELELVV 2046
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD---FSFSVTNKNCNGGASGVCLKSVTVIVGDLEITLQKGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  2047 NNQKMAIPYKVNEhLRVTMRS---HRLYLITNFELVVSFDGRNNAVISLPSMYEGLVRGLCGNYDQNRKNEFMLPNGT 2121
Cdd:pfam00094   78 NGQKVSLPYKSDG-GEVEILGsgfVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 384-545 1.50e-37

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 139.44  E-value: 1.50e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  384 CDFEDDahpFCDWTQASGDGGHWTRGSKNVPLQGTGPFGVSVNTEGHYIYLEAGkFSQAGQSSRLMSRPFCAP-GAICVE 462
Cdd:cd06263     1 CDFEDG---LCGWTQDSTDDFDWTRVSGSTPSPGTPPDHTHGTGSGHYLYVESS-SGREGQKARLLSPLLPPPrSSHCLS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  463 FSYHMYGLGEGaKLKLLLGSPAGSSPTSLWHRLGSQGLDWLNTSITVPSgRQQPMQLILEAIRGTNTAFVIAVGFIFINH 542
Cdd:cd06263    77 FWYHMYGSGVG-TLNVYVREEGGGLGTLLWSASGGQGNQWQEAEVTLSA-SSKPFQVVFEGVRGSGSRGDIALDDISLSP 154


                  ...
gi 955543215  543 GTC 545
Cdd:cd06263   155 GPC 157
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1570-1723 4.22e-36

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 135.22  E-value: 4.22e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   1570 CRISDDSHYISFDGTYHALKSTCTYVLVKVCHSTmdlPFFKISGKNGKREGQtpAFYLRQVNVDILDSLVTLQKGHR-VL 1648
Cdd:smart00216   12 CSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSE---PTFSVLLKNVPCGGG--ATCLKSVKVELNGDEIELKDDNGkVT 86

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 955543215   1649 INGTQVTLPSTSRIRGISVTARGAYTVLSINIGV-QVKFDGNGFLEIELPAAYYGKVCGMCGNFNGEEEDELMMPS 1723
Cdd:smart00216   87 VNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPD 162
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1967-2120 2.66e-33

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 127.13  E-value: 2.66e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   1967 CSVFGDPHYRTFDRLSYRFQGRMTYTLVKTVDVLPDgvepLVVEGRNKMYPPFSSIfLQEIIVMVYGYTVQL-QAELELV 2045
Cdd:smart00216   12 CSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPT----FSVLLKNVPCGGGATC-LKSVKVELNGDEIELkDDNGKVT 86

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 955543215   2046 VNNQKMAIPYKVNE-HLRVTMRSHRLYLITNFELV-VSFDGRNNAVISLPSMYEGLVRGLCGNYDQNRKNEFMLPNG 2120
Cdd:smart00216   87 VNGQQVSLPYKTSDgSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPDG 163
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 49-214 7.51e-32

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 122.86  E-value: 7.51e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    49 CDFEDDSkpLCDWTQVSTDDGDWARASRLSASgsTSPPGG--YPDGEGYYLHMDSNTFPRGGAAGLRSPPIWEQG-PLCV 125
Cdd:pfam00629    1 CDFEDGN--LCGWTQDSSDDFDWERVSGPSVK--TGPSSDhtQGTGSGHFMYVDTSSGAPGQTARLLSPLLPPSRsPQCL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   126 HFAYHMFGLSRGaQLKLLLLMgTKGRRPKLLWKHMNTQSPSWVPTTVTVPASgggpSSLPQLIFEGVRGSTAYLDIALDA 205
Cdd:pfam00629   77 RFWYHMSGSGVG-TLRVYVRE-NGGTLDTLLWSISGDQGPSWKEARVTLSSS----TQPFQVVFEGIRGGGSRGGIALDD 150


                   ....*....
gi 955543215   206 VSIRRGSCN 214
Cdd:pfam00629  151 ISLSSGPCP 159
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
 48-213 1.82e-28

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 113.21  E-value: 1.82e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215     48 HCDFEDDskPLCDWTQVSTDDGDWARASrlSASGSTSPPGGYPDGEGYYLHMDSNTFPRGGAAGLRSPPIWEQ-GPLCVH 126
Cdd:smart00137    5 NCDFEEG--STCGWHQDSNDDGHWERVS--SATGIPGPNRDHTTGNGHFMFFETSSGAEGQTARLLSPPLYENrSTHCLT 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    127 FAYHMFGLSRGA-QLKLLLLMGTKgrrPKLLWKHMNTQSPSWVPTTVTVPasgggPSSLP-QLIFEGVRGSTAYLDIALD 204
Cdd:smart00137   81 FWYYMYGSGSGTlNVYVRENNGSQ---DTLLWSRSGTQGGQWLQAEVALS-----SWPQPfQVVFEGTRGKGHSGYIALD 152


                    ....*....
gi 955543215    205 AVSIRRGSC 213
Cdd:smart00137  153 DILLSNGPC 161
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 222-376 2.69e-27

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 109.77  E-value: 2.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  222 CSFDTpnDLCGWSWIPTaSGAKWVQKKGSSGVLNVGPeDDFSSPGSGFYMLLDPKDAKPRQKCALLSPL---SRSSGCls 298
Cdd:cd06263     1 CDFED--GLCGWTQDST-DDFDWTRVSGSTPSPGTPP-DHTHGTGSGHYLYVESSSGREGQKARLLSPLlppPRSSHC-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  299 LSFQYTLHGRSPGaALNVYASVLGSIRKHTLF--SGHPRPNWQPVSVNY-TGQGQVQFTVVGVFGKIPEPAVAVDAISIA 375
Cdd:cd06263    75 LSFWYHMYGSGVG-TLNVYVREEGGGLGTLLWsaSGGQGNQWQEAEVTLsASSKPFQVVFEGVRGSGSRGDIALDDISLS 153


                  .
gi 955543215  376 P 376
Cdd:cd06263   154 P 154
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 222-378 1.29e-24

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 102.44  E-value: 1.29e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   222 CSFDTPNdLCGWsWIPTASGAKWVQKKGSSgvLNVGPEDDFS-SPGSGFYMLLDPKDAKPRQKCALLSPL---SRSSGCl 297
Cdd:pfam00629    1 CDFEDGN-LCGW-TQDSSDDFDWERVSGPS--VKTGPSSDHTqGTGSGHFMYVDTSSGAPGQTARLLSPLlppSRSPQC- 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   298 sLSFQYTLHGRSPGaALNVYASVLGSIRKHTLFS--GHPRPNWQPVSVNYTGQG---QVQFtvVGVFGKIPEPAVAVDAI 372
Cdd:pfam00629   76 -LRFWYHMSGSGVG-TLRVYVRENGGTLDTLLWSisGDQGPSWKEARVTLSSSTqpfQVVF--EGIRGGGSRGGIALDDI 151


                   ....*...
gi 955543215   373 SIA--PCG 378
Cdd:pfam00629  152 SLSsgPCP 159
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 990-1063 1.43e-20

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 87.78  E-value: 1.43e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 955543215    990 SGPEFCGQLVASHGAFEACLPHLRASSFFENCMFDMCNFQGLQLMLCAHMAALTETCQDAGYVVKPWRGPQFCP 1063
Cdd:smart00832    3 YACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1378-1449 3.72e-20

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 86.63  E-value: 3.72e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 955543215   1378 WNKNCDILMNPLGPFSQCHKVVPPHSSFTSCVYGQCGTKGDTLTLCRSLQAYASLCAQASQAP-AWRNSTFCP 1449
Cdd:smart00832    4 ACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCIsPWRTPTFCP 76
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2175-2250 4.55e-19

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 83.54  E-value: 4.55e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 955543215   2175 STQACRVLMDSQGPFATCHQTVAPEPFHEHCVFDLCAAQDprqREELRCQVLSGYAIICQEAGTALASWRDYTRCA 2250
Cdd:smart00832    4 ACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGG---DCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1382-1448 1.44e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.18  E-value: 1.44e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  1382 CDILMNPlGPFSQCHKVVPPHSSFTSCVYGQCGTKGDTLTLCRSLQAYASLCAQASQAPA-WRNSTFC 1448
Cdd:pfam08742    2 CGLLSDS-GPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGdWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 994-1062 2.04e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 72.80  E-value: 2.04e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 955543215   994 FCGQLVAShGAFEACLPHLRASSFFENCMFDMCNFQGLQLMLCAHMAALTETCQDAGYVVKPWRGPQFC 1062
Cdd:pfam08742    1 KCGLLSDS-GPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 2179-2249 2.34e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 72.41  E-value: 2.34e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 955543215  2179 CRVLMDSqGPFATCHQTVAPEPFHEHCVFDLCAAQDPRqreELRCQVLSGYAIICQEAGTALASWRDYTRC 2249
Cdd:pfam08742    2 CGLLSDS-GPFAPCHSVVDPEPYFEACVYDMCSCGGDD---ECLCAALAAYARACQAAGVCIGDWRTPTFC 68
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
 222-377 3.48e-15

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 75.46  E-value: 3.48e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    222 CSFDTPNdLCGWSWIpTASGAKWVQkkGSSGVLNVGPEDDfSSPGSGFYMLLDPKDAKPRQKCALLSPLSRS--SGClSL 299
Cdd:smart00137    6 CDFEEGS-TCGWHQD-SNDDGHWER--VSSATGIPGPNRD-HTTGNGHFMFFETSSGAEGQTARLLSPPLYEnrSTH-CL 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215    300 SFQYTLHGrSPGAALNVYASVLGSIRKHTLF--SGHPRPNWQPVSVNY-TGQGQVQFTVVGVFGKIPEPAVAVDAISIA- 375
Cdd:smart00137   80 TFWYYMYG-SGSGTLNVYVRENNGSQDTLLWsrSGTQGGQWLQAEVALsSWPQPFQVVFEGTRGKGHSGYIALDDILLSn 158


                    ...
gi 955543215    376 -PC 377
Cdd:smart00137  159 gPC 161
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1906-1960 5.50e-15

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 71.18  E-value: 5.50e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1906 CKDAQGGSLPAGKTWLSRGCTHRCACRAGAIQCGPFTCPSGSHCQPNStSTDNCA 1960
Cdd:pfam12714    1 CKDAQGNYIPAGKTWFSSGCTQSCTCTGGNIQCQPFQCPPGTVCKDND-GSSNCH 54
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 486-690 1.06e-14

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 80.35  E-value: 1.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   486 SSPTslwhrLGSQGLDWLNTSITVPSGRQQPMQLILEAIRG--TNTAFVIAVgfifINHGTCRGPAPtVLPSKSPVPLTG 563
Cdd:pfam05109  430 TSPT-----LNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGptVSTADVTSP----TPAGTTSGASP-VTPSPSPRDNGT 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   564 PSETPVFTgkplATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******TERTTVPTEKPTIPTEKPAVPTEKPTAPTTP 643
Cdd:pfam05109  500 ESKAPDMT----SPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLG 575

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 955543215   644 QPSPTLVPTRPAVSVMPP----SAPSTSMTTVSLATTAAPrPTPASCPPNA 690
Cdd:pfam05109  576 KTSPTSAVTTPTPNATSPtvgeTSPQANTTNHTLGGTSST-PVVTSPPKNA 625
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1066-1119 4.78e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.50  E-value: 4.78e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215 1066 CPPNSNYTLCARPCPDTCHSSFSGMACQDRCVEGCECNPGFVLS-GLQCVPQSQC 1119
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1509-1563 8.61e-14

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 67.71  E-value: 8.61e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1509 CTDQRGSYHPVGESWYTDNtCSRLCSCSTHNISCLPSACKPGQMCWPLDGLMRCR 1563
Cdd:pfam12714    1 CKDAQGNYIPAGKTWFSSG-CTQSCTCTGGNIQCQPFQCPPGTVCKDNDGSSNCH 54
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1066-1119 3.83e-13

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 65.87  E-value: 3.83e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1066 CPPNSNYTLCARPCPDTCHSSFSGMACQDRCVEGCECNPGFVLSGL-QCVPQSQC 1119
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNSGgKCVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 2253-2306 1.13e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 64.72  E-value: 1.13e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  2253 CPANTVYQSCMTPCPPSCANLAAPGDCEGPCVEGCASLPGYIYS-GAQSLPLAHC 2306
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 737-790 2.50e-12

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 63.48  E-value: 2.50e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 955543215   737 CVYNNNYYKPGVEWFSPNCTERCRCwPGSRMECQLSRCAIHTVCQLKDGQYGCH 790
Cdd:pfam12714    2 KDAQGNYIPAGKTWFSSGCTQSCTC-TGGNIQCQPFQCPPGTVCKDNDGSSNCH 54
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1452-1507 4.27e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 62.79  E-value: 4.27e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 955543215  1452 CPSGSSYSSCANPCPATCLSLTTPRDCPAalPCAEGCECQKGHVLS-GTSCVPLSQC 1507
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPE--PCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1452-1507 6.38e-12

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 62.33  E-value: 6.38e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 955543215 1452 CPSGSSYSSCANPCPATCLSLTTPRDCPAalPCAEGCECQKGHVLS-GTSCVPLSQC 1507
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTK--QCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 686-735 4.33e-11

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 60.09  E-value: 4.33e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215   686 CPPNAHYEPC--ACPASCESPKPT--CELVCQPGCVCNPGFLFN-DSRCVDASSC 735
Cdd:pfam01826    1 CPANEVYSECgsACPPTCANLSPPdvCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 1121-1175 7.50e-11

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 59.24  E-value: 7.50e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  1121 CLDPRAGYFKIGEQWFKPGCTQLCICEGsNRIRCVLWRCQAQEVCALQDGVYGCH 1175
Cdd:pfam12714    1 CKDAQGNYIPAGKTWFSSGCTQSCTCTG-GNIQCQPFQCPPGTVCKDNDGSSNCH 54
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 686-735 1.07e-10

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 58.87  E-value: 1.07e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  686 CPPNAHYEPC--ACPASCESPK--PTCELVCQPGCVCNPGFLFN-DSRCVDASSC 735
Cdd:cd19941     1 CPPNEVYSECgsACPPTCANPNapPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 2253-2296 1.09e-10

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 58.87  E-value: 1.09e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 955543215 2253 CPANTVYQSCMTPCPPSCANLAAPGDCEGPCVEGCASLPGYIYS 2296
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRN 44
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-694 5.09e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.73  E-value: 5.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  548 PAPTVLPSKSPVPlTGPSETPVFTG-------------KPLATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******TE 614
Cdd:PHA03247 2830 PPTSAQPTAPPPP-PGPPPPSLPLGgsvapggdvrrrpPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERP 2908

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  615 RTTVPTEKPTIPTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMPPS-----------APSTSMTTVSLATTAAP-RPT 682
Cdd:PHA03247 2909 PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSgavpqpwlgalVPGRVAVPRFRVPQPAPsREA 2988

                         170
                  ....*....|..
gi 955543215  683 PASCPPNAHYEP 694
Cdd:PHA03247 2989 PASSTPPLTGHS 3000
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1848-1904 6.37e-10

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 56.63  E-value: 6.37e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  1848 CPAFSTYTTCIPSCSLSCGDPEgqcKGTEVPATCKEGCVCLPGYVLS-EQRCVPRSQC 1904
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLS---PPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 479-694 9.50e-10

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 63.83  E-value: 9.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   479 LLGSPAGSSPTSLWHRL--GSQGLDWLNTSI---TVPS-----GRQQPMQLILEAIRGTNTAFVIAVGFIFINHGTCRGP 548
Cdd:pfam17823  114 ALAAAASSSPSSAAQSLpaAIAALPSEAFSApraAACRanasaAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASS 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   549 APTVLPSKSP---VPLTGPSETPVFTGKPLATTEKPTVPTEKPTVSTEKPTVPTENPtipt******TERTTVPTEKPTI 625
Cdd:pfam17823  194 APTTAASSAPatlTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTP----------AALATLAAAAGTV 263

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 955543215   626 PTEKPAVPTEKPTApTTPQPSPTLVPTRPAVSVMPPSAPSTSMTTVSLAT-----TAAPRPTPAscPPNAHYEP 694
Cdd:pfam17823  264 ASAAGTINMGDPHA-RRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTdqpvhNTAGEPTPS--PSNTTLEP 334
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 482-714 1.04e-09

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 63.44  E-value: 1.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   482 SPAGSSPTSLWHRLGSQGLDWLNTSITVPSGRQQPMQLILEAIRGTNTAfviAVGFIFINHGTCRGPAP---TVLPSKSp 558
Cdd:pfam17823  210 RGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAA---AAGTVASAAGTINMGDPharRLSPAKH- 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   559 VPLTGPSETPVFTGKPLATTEKPTVPTEKPTVSTE-KPTVPTENPTIP--T******TERTTVPTEK-----------PT 624
Cdd:pfam17823  286 MPSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAgEPTPSPSNTTLEpnTPKSVASTNLAVVTTTKaqakepsaspvPV 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   625 IPTEKpaVPTEKPTAPTTpQPSPtLVPTRPAvsvmppSAPSTSMTTVSLATTAAprPTPASCPPNahyepcacPASCESP 704
Cdd:pfam17823  366 LHTSM--IPEVEATSPTT-QPSP-LLPTQGA------AGPGILLAPEQVATEAT--AGTASAGPT--------PRSSGDP 425

                          250
                   ....*....|
gi 955543215   705 KPTCELVCQP 714
Cdd:pfam17823  426 KTLAMASCQL 435
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1777-1844 1.55e-09

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 56.23  E-value: 1.55e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215  1777 QCQAAFQAPAWAECATRVVLKPFLLGCTYKLCEFGGLNRVLCESVQAFGAACKAQGLKPPIWRNSSFC 1844
Cdd:pfam08742    1 KCGLLSDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1848-1904 2.23e-09

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 55.02  E-value: 2.23e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215 1848 CPAFSTYTTCIPSCSLSCGDPEGQ--CkgtevPATCKEGCVCLPGYVLSEQ-RCVPRSQC 1904
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPppC-----TKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
Metaviral_G pfam09595
Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. ...
 588-707 2.97e-09

Metaviral_G glycoprotein; This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated.


Pssm-ID: 462833 [Multi-domain]  Cd Length: 183  Bit Score: 58.81  E-value: 2.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   588 PTVST-EKPTVPTENPTIPT******TERTTVPTEKPT---IPTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMP--- 660
Cdd:pfam09595   36 IGESNkEAALIITDIIDININKQHPEQEHHENPPLNEAakeAPSESEDAPDIDPNNQHPSQDRSEAPPLEPAAKTKPseh 115

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 955543215   661 -PSAPSTSMTTVSL--ATTAAPRPTPASCPPNAHYEPCACPASCESPKPT 707
Cdd:pfam09595  116 ePANPPDASNRLSPpdASTAAIREARTFRKPSTGKRNNPSSAQSDQSPPR 165
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 2308-2361 4.39e-09

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 54.23  E-value: 4.39e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 955543215  2308 CTHNGIYYQQGDSFVTEDCSQRCTCASlGVLLCEPLSCGAGEICTLGNLTRGCF 2361
Cdd:pfam12714    2 KDAQGNYIPAGKTWFSSGCTQSCTCTG-GNIQCQPFQCPPGTVCKDNDGSSNCH 54
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1788-1845 2.08e-08

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 53.11  E-value: 2.08e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215   1788 AECATRVVLKPFLLGCTYKLCEFGGLNRVLCESVQAFGAACKAQGLKPPIWRNSSFCP 1845
Cdd:smart00832   19 AACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 502-706 2.61e-08

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 59.54  E-value: 2.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   502 WLNTSITvPSGRQQpmqliLEAIRGTNTAFVIAVGFIfinhgtcrGPAP-TVLPSKSPVPLTGPSETPVFTGKPLATTEK 580
Cdd:pfam05109  366 WTLTSGT-PSGCEN-----ISGAFASNRTFDITVSGL--------GTAPkTLIITRTATNATTTTHKVIFSKAPESTTTS 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   581 PT--------------------VPTEKPTVSTEKPTVPTENPTIPT******TERTTVPTEKP------------TIPTE 628
Cdd:pfam05109  432 PTlnttgfaapntttglpssthVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPrdngteskapdmTSPTS 511

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   629 KPAVPTEKPTAP----TTPQP---SPTLVPTRPAVSVMPPSAPSTSmttvslATTAAPRPTP-ASCPPNAHYEPCacpAS 700
Cdd:pfam05109  512 AVTTPTPNATSPtpavTTPTPnatSPTLGKTSPTSAVTTPTPNATS------PTPAVTTPTPnATIPTLGKTSPT---SA 582


                   ....*.
gi 955543215   701 CESPKP 706
Cdd:pfam05109  583 VTTPTP 588
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-714 7.01e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 7.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  548 PAPTVLPSKSPVPLTGPSETPVFTGKPL-----ATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******TERTTVPT-- 620
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPALPAapappAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAva 2789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  621 ---------EKPTIPTEKPA-VPTEKPTAPTTPQPSPTLVPTRPAVSVMPPSAPSTSMTTVSLATTAAP------RPTPA 684
Cdd:PHA03247 2790 slsesreslPSPWDPADPPAaVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrRPPSR 2869

                         170       180       190
                  ....*....|....*....|....*....|..
gi 955543215  685 SCP--PNAHYEPCACPASCESPKPTCELVCQP 714
Cdd:PHA03247 2870 SPAakPAAPARPPVRRLARPAVSRSTESFALP 2901
PHA03247 PHA03247
large tegument protein UL36; Provisional
 546-688 7.44e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 7.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  546 RGPAPTVLPSKSPVPLTgpSETPVFTGKPLATTEKPTVP-TEKPTVSTEKPTVPTENPTIPT******TERTTVPTEKPT 624
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALV--SATPLPPGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA 2777

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 955543215  625 IP---TEKPAVPTEKPTAPTTPQPS----PTLVPTRPAVSVMPPSAPSTSMTTVSLATTAAPRPTPASCPP 688
Cdd:PHA03247 2778 GPprrLTRPAVASLSESRESLPSPWdpadPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPP 2848
PHA03378 PHA03378
EBNA-3B; Provisional
 541-690 8.38e-08

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 58.15  E-value: 8.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  541 NHGTCRGP--APTVL--PSKSPVPLTGPSETPVFTGKPLATTEKPTVPTEKPTVSTEKPTVPTENP---TIPT******T 613
Cdd:PHA03378  680 GANTMLPIqwAPGTMqpPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARppaAAPGRARPPAA 759

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  614 ERTTVPTEK-------PTIPTEKPAVPTEKPTAPTTPQPSPTLVPTrpAVSVMPPSAPS----TSMTTVSLATTAAPRPT 682
Cdd:PHA03378  760 APGRARPPAaapgaptPQPPPQAPPAPQQRPRGAPTPQPPPQAGPT--SMQLMPRAAPGqqgpTKQILRQLLTGGVKRGR 837


                  ....*...
gi 955543215  683 PASCPPNA 690
Cdd:PHA03378  838 PSLKKPAA 845
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-707 1.57e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  548 PAPTVLPSKSPVPLTGPSETPVFTGKPLATTEKPTVPTEKPTVST----------EKPTVPTENPTIPT******TERTT 617
Cdd:PHA03247 2650 ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSltsladppppPPTPEPAPHALVSATPLPPGPAAAR 2729

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  618 VPTEKPTIPTEKPAVPTEK--PTAPTTP-QPSPTLVPTRPAVSVMPPSAPSTSMT-----TVSLATTAAPRP------TP 683
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPatPGGPARPaRPPTTAGPPAPAPPAAPAAGPPRRLTrpavaSLSESRESLPSPwdpadpPA 2809

                         170       180
                  ....*....|....*....|....
gi 955543215  684 ASCPPNAHYEPCACPASCESPKPT 707
Cdd:PHA03247 2810 AVLAPAAALPPAASPAGPLPPPTS 2833
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 534-715 1.58e-07

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 56.70  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  534 AVGFIFINHGTCRGPAPTVLPSKS-PVPLTGPS-ETPVFTGKPLATTEKPTVpteKPTVSTEKPTVPTE----NPTIPT* 607
Cdd:NF033839  270 AVVTKFKKGLTQDTPKEPGNKKPSaPKPGMQPSpQPEKKEVKPEPETPKPEV---KPQLEKPKPEVKPQpekpKPEVKPQ 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  608 *****TE-----RTTVPTEKPTIPTEKPAVP----TEKPTA---PTTPQPSPTLVPTRPAVSVMP-PSAPSTSMTTVSLA 674
Cdd:NF033839  347 LETPKPEvkpqpEKPKPEVKPQPEKPKPEVKpqpeTPKPEVkpqPEKPKPEVKPQPEKPKPEVKPqPEKPKPEVKPQPEK 426

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 955543215  675 TTAAPRPTPASCPPNAHYEPcacpascESPKPtcELVCQPG 715
Cdd:NF033839  427 PKPEVKPQPEKPKPEVKPQP-------EKPKP--EVKPQPE 458
PHA03247 PHA03247
large tegument protein UL36; Provisional
 546-707 1.90e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  546 RGPAPTVLPSKSPVPLTGPSETPVFTGKPLATT--EKPTVPTEKPTVSTEKPTVPTENPTIPT******TeRTTVPTEKP 623
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEpdPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAA-QASSPPQRP 2683

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  624 TIPTEKPAVPT-----EKPTAPTTPQPSPT-LVPTRP---------AVSVMPPSAPSTSMTTVSLATTAAPRPTPASCPP 688
Cdd:PHA03247 2684 RRRAARPTVGSltslaDPPPPPPTPEPAPHaLVSATPlppgpaaarQASPALPAAPAPPAVPAGPATPGGPARPARPPTT 2763

                         170
                  ....*....|....*....
gi 955543215  689 NAHYEPCACPASCESPKPT 707
Cdd:PHA03247 2764 AGPPAPAPPAAPAAGPPRR 2782
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-706 5.71e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 5.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  548 PAPTVlPSKSPVPLTGPSETPVFTGKPLATTEKPTVPTEKPTVSTEKPTVPTEnPTIPT******TERTTVPTEKPTIPT 627
Cdd:PHA03247 2799 PSPWD-PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAKPA 2876

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  628 EKPAVPTEK-----PTAPTTPQPSPTLVPTRPAvsvmPPSAPSTSMTTVSLATTAAPRPTPASCP-PNAHYEPCACPASC 701
Cdd:PHA03247 2877 APARPPVRRlarpaVSRSTESFALPPDQPERPP----QPQAPPPPQPQPQPPPPPQPQPPPPPPPrPQPPLAPTTDPAGA 2952


                  ....*
gi 955543215  702 ESPKP 706
Cdd:PHA03247 2953 GEPSG 2957
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 547-706 8.30e-07

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 54.39  E-value: 8.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  547 GPAPTVLPS-KSPVPLTGPS-ETPVFTGKPLATTEKPTVpteKPTVSTEKPTVPTEnPTIPT******TErTTVPTEKPT 624
Cdd:NF033839  338 KPKPEVKPQlETPKPEVKPQpEKPKPEVKPQPEKPKPEV---KPQPETPKPEVKPQ-PEKPKPEVKPQPE-KPKPEVKPQ 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  625 IPTEKPAVPT--EKPT-----APTTPQPSPTLVPTRPAVSVMP-PSAPSTSMttvslattaapRPTPASCPPNAHYEPca 696
Cdd:NF033839  413 PEKPKPEVKPqpEKPKpevkpQPEKPKPEVKPQPEKPKPEVKPqPETPKPEV-----------KPQPEKPKPEVKPQP-- 479

                         170
                  ....*....|
gi 955543215  697 cpascESPKP 706
Cdd:NF033839  480 -----EKPKP 484
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-714 9.53e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 9.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  548 PAPTVLPSKSPVPLT-------GPSETPVFTGKPLATTeKPTVPTEKPTVSTEKPTVPTENPTIPT******TERTTVPT 620
Cdd:PHA03247 2733 PALPAAPAPPAVPAGpatpggpARPARPPTTAGPPAPA-PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV 2811

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  621 EKPTI---PTEKPAVPTEKPTA------PTTPQPSPTLVPT-----------RPAVSVMPPSAPSTS--MTTVSLATTAA 678
Cdd:PHA03247 2812 LAPAAalpPAASPAGPLPPPTSaqptapPPPPGPPPPSLPLggsvapggdvrRRPPSRSPAAKPAAParPPVRRLARPAV 2891

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 955543215  679 PRPTPASCPPNAHYEPCACPASCESPKPTCELVCQP 714
Cdd:PHA03247 2892 SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPP 2927
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-706 1.18e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  548 PAPTVLPSKSPVPLTGPSETPV---FTGKPLATTEKPTVPTEKPTVSTEKPTVPTENPTI--PT******TERTTVPTEK 622
Cdd:PHA03247 2751 PGGPARPARPPTTAGPPAPAPPaapAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAvlAPAAALPPAASPAGPLPP 2830

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  623 PTIPTEKPAVPTEKPTAPTTP-----------------QPSPTLV--PTRPAVSVMPPSAPSTSMTTVSLATTAAPRPTP 683
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPlggsvapggdvrrrppsRSPAAKPaaPARPPVRRLARPAVSRSTESFALPPDQPERPPQ 2910

                         170       180
                  ....*....|....*....|...
gi 955543215  684 ASCPPNAHYEPCACPASCESPKP 706
Cdd:PHA03247 2911 PQAPPPPQPQPQPPPPPQPQPPP 2933
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
2308-2371 1.57e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 47.56  E-value: 1.57e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 955543215   2308 CTHNGIYYQQGDSFVtEDCsQRCTCASlGVLLCEPLSCGAGEiCTLGNLTRGCFRESP-------CLRNPC 2371
Cdd:smart00215    1 CWNNGSYYPPGAKWD-DDC-NRCTCLN-GRVSCTKVWCGPKP-CLLHNLSGECPLGQGcvpslsdCLSSPC 67
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 554-707 2.58e-06

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 52.62  E-value: 2.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  554 PSKSPVPLTGPSETPVFTGKPLATT--EKPTVPTEKPTVST-----------EKPTVPTENPTIPT******TERTTVPT 620
Cdd:PLN03209  329 PPKESDAADGPKPVPTKPVTPEAPSppIEEEPPQPKAVVPRplspytayedlKPPTSPIPTPPSSSPASSKSVDAVAKPA 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  621 EK---------PTIPTEKPAVPTEKPTAPTTP-----------QPSPT-LVPTRPAVSVmPPSAPSTSMTTVSLATTAAP 679
Cdd:PLN03209  409 EPdvvpspgsaSNVPEVEPAQVEAKKTRPLSPyaryedlkpptSPSPTaPTGVSPSVSS-TSSVPAVPDTAPATAATDAA 487

                         170       180
                  ....*....|....*....|....*...
gi 955543215  680 RPTPASCPPNAHYEPCACPASCESPKPT 707
Cdd:PLN03209  488 APPPANMRPLSPYAVYDDLKPPTSPSPA 515
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 543-707 8.31e-06

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 51.08  E-value: 8.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  543 GTCRGPAPTVLPSKSP---VPLTGPSETPVFTGKPLA-----------TTEKPTVPTEKPTVSTEKPTVPTENPTIPt** 608
Cdd:PLN03209  403 AVAKPAEPDVVPSPGSasnVPEVEPAQVEAKKTRPLSpyaryedlkppTSPSPTAPTGVSPSVSSTSSVPAVPDTAP--- 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  609 ****TERTTVPTEKPTIPTEKPAVPTEKP-TAPTTPQPSPTLVPTR-PAVSVMPPSAPSTSMttVSLATTAAPRPTPASc 686
Cdd:PLN03209  480 ATAATDAAAPPPANMRPLSPYAVYDDLKPpTSPSPAAPVGKVAPSStNEVVKVGNSAPPTAL--ADEQHHAQPKPRPLS- 556

                         170       180
                  ....*....|....*....|.
gi 955543215  687 pPNAHYEPCACPAsceSPKPT 707
Cdd:PLN03209  557 -PYTMYEDLKPPT---SPTPS 573
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 547-717 1.39e-05

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 50.66  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   547 GPAPTVLPSKSPvpltgPSETPVFTgkPLATTEkPTVPTEKPtvSTEKPTVPTENPTI-PT******TERTTVPTEKPTi 625
Cdd:pfam15324  967 PPVAASVPGDLP-----TKETLLPT--PVPTPQ-PTPPCSPP--SPLKEPSPVKTPDSsPCVSEHDFFPVKEIPPEKGA- 1035

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   626 PTEKPAVPTEKPTAptTPQPSPTLVPTrpavsvmpPSAPSTSMTTVSLATTAAPRPTPascppnahYEPCACPASCESPK 705
Cdd:pfam15324 1036 DTGPAVSLVITPTV--TPIATPPPAAT--------PTPPLSENSIDKLKSPSPELPKP--------WEDSDLPLEEENPN 1097

                          170
                   ....*....|..
gi 955543215   706 PTCELVcQPGCV 717
Cdd:pfam15324 1098 SEQEEL-HPRAV 1108
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 549-688 1.58e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 49.96  E-value: 1.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   549 APTVLPSksPVPLTgpsetpvfTGKPLATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******TERT--TVPTEKPTIP 626
Cdd:pfam17823   62 AATAAPA--PVTLT--------KGTSAAHLNSTEVTAEHTPHGTDLSEPATREGAADGAASRALAAAAssSPSSAAQSLP 131

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 955543215   627 TEKPAVPTEKPTAPTTPQPS--PTLVPTRPAVSVMPPSAPSTSMTTVSLATTAAPRPTPASCPP 688
Cdd:pfam17823  132 AAIAALPSEAFSAPRAAACRanASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAP 195
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 565-706 2.90e-05

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 48.32  E-value: 2.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  565 SETPVFTGKPLATTEKPTVPT--EKPTVSTEKPTVpTENPTIPT******TERTTVPT-EKPTIPTekPAVPTEKPTAPT 641
Cdd:PHA02682   21 TSSSLFTKCPQATIPAPAAPCppDADVDPLDKYSV-KEAGRYYQSRLKANSACMQRPSgQSPLAPS--PACAAPAPACPA 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 955543215  642 TPQPSPTLVPTRPAVSvmPPSAPSTSMTTVSLATTAAPRPTPASCPPNAHYEPCACPASCESPKP 706
Cdd:PHA02682   98 CAPAAPAPAVTCPAPA--PACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLPTPKPAP 160
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 564-679 4.42e-05

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 47.93  E-value: 4.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  564 PSETPVFTGKPLATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******TERTTVPTEKPTIPTEKPAVPTEKPTAP-TT 642
Cdd:PHA02682   76 PSGQSPLAPSPACAAPAPACPACAPAAPAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPlPT 155

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 955543215  643 PQPSPTLVPTRPAVSVMPPSAPSTSMTTVSLATTAAP 679
Cdd:PHA02682  156 PKPAPAAKPIFLHNQLPPPDYPAASCPTIETAPAASP 192
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 572-694 4.67e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 48.84  E-value: 4.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   572 GKPLATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******--------TERTTVPTEKPTIPTEKPAV--PTEKPTAPT 641
Cdd:TIGR00927  302 GKNNLTTPQGTVLEHTPATSEGQVTISIMTGSSPAETKASTaawkirnpLSRTSAPAVRIASATFRGLEknPSTAPSTPA 381

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 955543215   642 TPQ--PSPTlVPTRPAVSVMP----PSAPSTSMTTVSLATTAAPRPT--PASCP---PNAHYEP 694
Cdd:TIGR00927  382 TPRvrAVLT-TQVHHCVVVKPapavPTTPSPSLTTALFPEAPSPSPSalPPGQPdlhPKAEYPP 444
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 575-691 5.77e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 48.27  E-value: 5.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  575 LATTEKPTVPTEKPTVSTEKPTVPTENPTIPT******TERTTVPTEKPTIPTEKPAvPTEKPTAPTTPQPSPTLVPTRP 654
Cdd:PRK14950  341 LRTTSYGQLPLELAVIEALLVPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANI-PPKEPVRETATPPPVPPRPVAP 419

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 955543215  655 AVSVMPPSAPSTsmTTVSLATTAAPRPTPASCPPNAH 691
Cdd:PRK14950  420 PVPHTPESAPKL--TRAAIPVDEKPKYTPPAPPKEEE 454
PRK10905 PRK10905
cell division protein DamX; Validated
 582-685 6.63e-05

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 47.63  E-value: 6.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  582 TVPTEKPTVStekptvPTENPTIPT******TER---TTVPTEKPT-IPTEKP-----AVPTEKPTAPTTPQPSPTLVPT 652
Cdd:PRK10905  122 TLPTEPATVA------PVRNGNASRQTAKTQTAErpaTTRPARKQAvIEPKKPqatakTEPKPVAQTPKRTEPAAPVAST 195

                          90       100       110
                  ....*....|....*....|....*....|....
gi 955543215  653 R-PAVSVMPPSAPSTSMTTVSLATTAAPRPTPAS 685
Cdd:PRK10905  196 KaPAATSTPAPKETATTAPVQTASPAQTTATPAA 229
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 544-715 7.11e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.37  E-value: 7.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   544 TCRGPAPTVLPSKSPVPLTGPseTPVFTG-KPLATTEKP--TVPTEKPTVSTEKPTVPTENPTIPT******TERTTVPT 620
Cdd:pfam05109  531 TPNATSPTLGKTSPTSAVTTP--TPNATSpTPAVTTPTPnaTIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHT 608

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   621 EKPTIPTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMPPS-----APSTSMTTVS---LATTAAP-------RPTPAS 685
Cdd:pfam05109  609 LGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSisetlSPSTSDNSTShmpLLTSAHPtggenitQVTPAS 688

                          170       180       190
                   ....*....|....*....|....*....|.
gi 955543215   686 CppNAHYEPCACPAscesPKP-TCELVCQPG 715
Cdd:pfam05109  689 T--STHHVSTSSPA----PRPgTTSQASGPG 713
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-707 8.56e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 8.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  548 PAPTVLPSKSP---VPLTGPSETPVftgKPLATTE--KPTVPTEK--------PTVSTEKPTVPTENPTIPT******TE 614
Cdd:PHA03247 2554 PLPPAAPPAAPdrsVPPPRPAPRPS---EPAVTSRarRPDAPPQSarprapvdDRGDPRGPAPPSPLPPDTHAPDPPPPS 2630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  615 RTTVPTEKP---TIPTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMPP------SAPSTSMTTVSLATTAAPRPTPAS 685
Cdd:PHA03247 2631 PSPAANEPDphpPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqrprrrAARPTVGSLTSLADPPPPPPTPEP 2710

                         170       180
                  ....*....|....*....|..
gi 955543215  686 CPPnahyepcacPASCESPKPT 707
Cdd:PHA03247 2711 APH---------ALVSATPLPP 2723
PHA03247 PHA03247
large tegument protein UL36; Provisional
 546-685 1.11e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  546 RGPAPTVLPSKSPVPLtgPSETPvftgKPLATTEKPTVPTEKPTV-STEKPTVPTENPTIPT******TERTTVPTEKPT 624
Cdd:PHA03247 2885 RLARPAVSRSTESFAL--PPDQP----ERPPQPQAPPPPQPQPQPpPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGA 2958

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 955543215  625 IPTEK--PAVPTEKPTAPT-TPQPSPTlVPTrPAVSVMPP---SAPSTSMTTVSLATTAAPRPTPAS 685
Cdd:PHA03247 2959 VPQPWlgALVPGRVAVPRFrVPQPAPS-REA-PASSTPPLtghSLSRVSSWASSLALHEETDPPPVS 3023
PHA03247 PHA03247
large tegument protein UL36; Provisional
 539-734 1.26e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  539 FINHGTCRGPAPTVLPSK---SPVPLTGPSETPvfTGKPLATTEKPTVPTEKPTVSTEKPTVPT---------------E 600
Cdd:PHA03247 2474 FPGAPVYRRPAEARFPFAagaAPDPGGGGPPDP--DAPPAPSRLAPAILPDEPVGEPVHPRMLTwirgleelasddagdP 2551

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  601 NPTIPT******TERTtVPTEKPTIPTEKPAVPTE--KPTAPttPQPsptlvpTRPAVSVMPPSAPSTSMTTVSLATTAA 678
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRS-VPPPRPAPRPSEPAVTSRarRPDAP--PQS------ARPRAPVDDRGDPRGPAPPSPLPPDTH 2622

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 955543215  679 PRPTPASCPPNAHYEPCACPASCESPKPTCELVCQPGCVCNPGFLFNDSRCVDASS 734
Cdd:PHA03247 2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 574-663 1.75e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 46.73  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  574 PLATTEKPTVPTekPTVSTEKPTvPTENPTIPT******TE--RTTVPTEKPTIPTEKPAVPTEKPTAPTTPQPSPTLVP 651
Cdd:PRK14950  364 PAPQPAKPTAAA--PSPVRPTPA-PSTRPKAAAAANIPPKEpvRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDE 440

                          90
                  ....*....|..
gi 955543215  652 TRPAVSVMPPSA 663
Cdd:PRK14950  441 KPKYTPPAPPKE 452
PHA03378 PHA03378
EBNA-3B; Provisional
 548-705 1.78e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.98  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  548 PAPTVLPSKSPVPLTGPS-ETPVFTGKPLATTEKPTvpTEKPTVSTEKPTvPTENPTIPT******TERTTVPTEKPTIP 626
Cdd:PHA03378  630 PIPMRPLRMQPITFNVLVfPTPHQPPQVEITPYKPT--WTQIGHIPYQPS-PTGANTMLPIQWAPGTMQPPPRAPTPMRP 706

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  627 TEKPAVPTEKPTAPTTPQPSPTLVPTR---PAVS---VMPPSAPSTSMTTVSLATTAAPRPTPASCPPNAHYEPCACPAS 700
Cdd:PHA03378  707 PAAPPGRAQRPAAATGRARPPAAAPGRarpPAAApgrARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAP 786


                  ....*
gi 955543215  701 CESPK 705
Cdd:PHA03378  787 QQRPR 791
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
547-706 3.04e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.38  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  547 GPAPTVLPSKSPVPltGPSETPVFTGKPLATTEKPTV-PTEKPTVSTEKPTVPTENPTIPT******TERTTVPTEKPTI 625
Cdd:PRK07003  370 GGVPARVAGAVPAP--GARAAAAVGASAVPAVTAVTGaAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  626 PTEKPA---VPTEKPTAPTTPQPSPTLVPTRPAVSVMPPSAPSTSMTTVSLATTAAPRPTPASCPPNAHYEPCAcPASCE 702
Cdd:PRK07003  448 PVPAKAnarASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDA-PAAAA 526


                  ....
gi 955543215  703 SPKP 706
Cdd:PRK07003  527 PPAP 530
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
575-698 3.18e-04

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 45.69  E-value: 3.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   575 LATTEKPTVPTEKPTVSTEKPT----VPTENPTIPT--******TERTTVPTEKPT-IPTekPAVPTEKPTAPTTPQPSP 647
Cdd:pfam16014    2 LGSSPRPSILRKKPATEGAKPKpdihVAVAPPVTVAveALPGQNSEQQTASASPPSqHPA--QAIPTILAPAAPPSQPSV 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 955543215   648 TLVPTRPAVSVMPPsapstsmTTVSLATTAAPRPTPASCPPNAHYEPCACP 698
Cdd:pfam16014   80 VLSTLPAAMAVTPP-------IPASMANVVAPPTQPAASSTAACAVSSVLP 123
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 546-706 3.52e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  546 RGPAPTVLPSKSPVPLTGPSETPVFTGKPLATTEKPTVPTEKPTVSTEKPTVPTENPTIPt******TERTTVPTEKPTI 625
Cdd:PHA03307   64 RFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPP--ASPPPSPAPDLSEMLRPV 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  626 PTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMPPSAPSTSMTTVSLATTAAPRPTPASCPPNAH--YEPCACPASCES 703
Cdd:PHA03307  142 GSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPrrSSPISASASSPA 221


                  ...
gi 955543215  704 PKP 706
Cdd:PHA03307  222 PAP 224
Cu_amine_oxidN1 pfam07833
Copper amine oxidase N-terminal domain; Copper amine oxidases catalyze the oxidative ...
 853-915 3.77e-04

Copper amine oxidase N-terminal domain; Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.


Pssm-ID: 400265 [Multi-domain]  Cd Length: 93  Bit Score: 41.43  E-value: 3.77e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 955543215   853 STVYVTLPETTVTLLKGRRTL-VGGQQVTLPAMPS--KGVFLAPsGRFVElqTAFGLRVRWDGDQQ 915
Cdd:pfam07833   27 KTVTITKGGTTIKLTIGSNTAtVNGQEITLDVPPVliNGRTYVP-LRFVA--EALGAKVDWDEATR 89
PRK11901 PRK11901
hypothetical protein; Reviewed
 616-692 3.89e-04

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 45.06  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  616 TTVPTEKPTI-PTEKPAVPTEKPTAPTTPQPSPTlvpTRPAVSvmPPSAPSTSMTTvslATTAAPRPTPASCP-----PN 689
Cdd:PRK11901  172 STLPTAPATVaPSKGAKVPATAETHPTPPQKPAT---KKPAVN--HHKTATVAVPP---ATSGKPKSGAASARalssaPA 243


                  ...
gi 955543215  690 AHY 692
Cdd:PRK11901  244 SHY 246
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 589-707 4.08e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 45.49  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  589 TVSTEKPTVPTENPTIPT**-****TERTTVPTEKPTIPTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMPPSAPSTS 667
Cdd:PHA03269   11 TIACINLIIANLNTNIPIPElHTSAATQKPDPAPAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQ 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 955543215  668 MTT------VSLATTAAPRPTPASCP---PNAHYEPCACPASCESPKPT 707
Cdd:PHA03269   91 AASrapdpaVAPQLAAAPKPDAAEAFtsaAQAHEAPADAGTSAASKKPD 139
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 614-707 4.40e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.48  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  614 ERTTVPTEKPTIPTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMPPSAPSTSMTtvslATTAAPRPTPASCPPNAHYE 693
Cdd:PRK14951  377 EKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAA----APAAAPAAAPAAVALAPAPP 452

                          90
                  ....*....|....
gi 955543215  694 PCACPASCESPKPT 707
Cdd:PRK14951  453 AQAAPETVAIPVRV 466
rne PRK10811
ribonuclease E; Reviewed
 554-711 4.72e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 45.80  E-value: 4.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  554 PSKSPVPLTGPSETP-VFTGK-----PLAT-TEKPTVPTEKPTVSTEKPTVPTENPTIPT******TERTTVPT-EKPTI 625
Cdd:PRK10811  820 PTQSPMPLTVACASPeMASGKvwiryPVVRpQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEvVEEPV 899

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  626 PTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVsVMPPSAPSTSMTTVSLATTAAPRPTPASCPPNAHYEPCACPASCESPK 705
Cdd:PRK10811  900 VVAEPQPEEVVVVETTHPEVIAAPVTEQPQV-ITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQ 978


                  ....*.
gi 955543215  706 PTCELV 711
Cdd:PRK10811  979 PAAPVV 984
PRK11633 PRK11633
cell division protein DedD; Provisional
 581-690 5.97e-04

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 43.84  E-value: 5.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  581 PTVPteKPTVSTEKPTVPTENPTIPT******TER-----TTVPTEKPTI--PTEKPAVPTEKPTAPTTPQPSPTLVP-T 652
Cdd:PRK11633   42 PLVP--KPGDRDEPDMMPAATQALPTQPPEGAAEAvragdAAAPSLDPATvaPPNTPVEPEPAPVEPPKPKPVEKPKPkP 119

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 955543215  653 RPAVSVMPPSAPstsmttvslattaAPRPTPASCPPNA 690
Cdd:PRK11633  120 KPQQKVEAPPAP-------------KPEPKPVVEEKAA 144
PRK11901 PRK11901
hypothetical protein; Reviewed
 582-682 6.02e-04

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 44.67  E-value: 6.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  582 TVPTEKPTVSTEKPTVPTENPTIPt******terttvPTEKPTIPTEKPAV-PTEKPTAPTTPQPSPTLVPTRPAVSVMp 660
Cdd:PRK11901  173 TLPTAPATVAPSKGAKVPATAETH-------------PTPPQKPATKKPAVnHHKTATVAVPPATSGKPKSGAASARAL- 238

                          90       100
                  ....*....|....*....|..
gi 955543215  661 PSAPSTSMTtvsLATTAAPRPT 682
Cdd:PRK11901  239 SSAPASHYT---LQLSSASRSD 257
PHA03247 PHA03247
large tegument protein UL36; Provisional
 549-705 6.91e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 6.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  549 APTVLPSKSPVPLTGPSETPVFTGKPLATTEKpTVPTEKP----TVSTEKPTVPTENPtiPT******TERTTVPTEKPT 624
Cdd:PHA03247  305 APLALPAPPDPPPPAPAGDAEEEDDEDGAMEV-VSPLPRPrqhyPLGFPKRRRPTWTP--PSSLEDLSAGRHHPKRASLP 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  625 IPTEKPAVPTEKP----------TAPTTPQPSPTLVPTRPAVSVMPPSAPSTSMTTVSLATTAAPRPTPASCPPNAHYEP 694
Cdd:PHA03247  382 TRKRRSARHAATPfargpggddqTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEP 461

                         170
                  ....*....|.
gi 955543215  695 CACPASCESPK 705
Cdd:PHA03247  462 APDDPDDATRK 472
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
 543-700 7.16e-04

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 44.42  E-value: 7.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   543 GTCRGPAPTVLPSKSPVPLTGPSETPvftgkplatteKPTVPTEKPTVSTEKPTVPTENPTIPT******TERTTVPTEK 622
Cdd:pfam15279   90 SESVSPGPSSSASPSSSPTSSNSSKP-----------LISVASSSKLLAPKPHEPPSLPPPPLPPKKGRRHRPGLHPPLG 158

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955543215   623 PTIPTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMPPSAPSTSMTTVSLATTAAPRPTPASCPPNAHYEPCACPAS 700
Cdd:pfam15279  159 RPPGSPPMSMTPRGLLGKPQQHPPPSPLPAFMEPSSMPPPFLRPPPSIPQPNSPLSNPMLPGIGPPPKPPRNLGPPSN 236
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 547-688 1.26e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.93  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  547 GPAPTVLPSKSPVPLTGPSETPvftgKPLATTEKPTVPTEKPTVSTEKPTVPTENPtipt******terttVPTEKPTIP 626
Cdd:PRK14951  370 AEAAAPAEKKTPARPEAAAPAA----APVAQAAAAPAPAAAPAAAASAPAAPPAAA---------------PPAPVAAPA 430

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 955543215  627 TEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMPPSAPSTSMTtvSLATTAAPRPTPASCPP 688
Cdd:PRK14951  431 AAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVA--SAAPAPAAAPAAARLTP 490
VWC smart00214
von Willebrand factor (vWF) type C domain;
2308-2354 1.62e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.65  E-value: 1.62e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 955543215   2308 CTHNGIYYQQGDSFvTEDCSQRCTCASLGVLLCEPLSCGAGEICTLG 2354
Cdd:smart00214    1 CVHNGRVYNDGETW-KPDPCQICTCLDGTTVLCDPVECPPPPDCPNP 46
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 562-664 1.75e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.83  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215   562 TGPSETPVFT-----GKPLATTEKPTVPTEKPTV--STEKPTVPTENPTIPT******terttvpteKPTIPTEKPAVPT 634
Cdd:TIGR00927  333 SSPAETKASTaawkiRNPLSRTSAPAVRIASATFrgLEKNPSTAPSTPATPRVRA------------VLTTQVHHCVVVK 400

                           90       100       110
                   ....*....|....*....|....*....|....
gi 955543215   635 EKPTAPTTPQPSPT--LVPT--RPAVSVMPPSAP 664
Cdd:TIGR00927  401 PAPAVPTTPSPSLTtaLFPEapSPSPSALPPGQP 434
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 626-706 2.28e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 43.26  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955543215  626 PTEKPAVPTEKPTAPTTPQPSPTLVPTRPAVSVMPPSAPSTSM---TTVSLATTAAPRPTPASCPPNAHYEPCACPASCE 702
Cdd:PRK14950  364 PAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETatpPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEKPK 443


                  ....
gi 955543215  703 SPKP 706
Cdd:PRK14950  444 YTPP 447
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2366-2395 3.35e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.35e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 955543215  2366 CLRNPCQNDGRCQEQGPYFTCECELGYGGD 2395
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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