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Conserved domains on  [gi|926794703|ref|XP_013905825|]
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hypothetical protein MNEG_1142 [Monoraphidium neglectum]

Protein Classification

uL14 family ribosomal protein( domain architecture ID 10446403)

uL14 family ribosomal protein such as bacterial 50S ribosomal protein L14 that binds to the 23S rRNA and forms part of two intersubunit bridges in the 70S ribosome

Gene Ontology:  GO:0015934|GO:0006412|GO:0003735
PubMed:  24524803
SCOP:  4001826

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_uL14 cd00337
Ribosomal protein uL14; Ribosomal protein uL14 (L14 in bacteria and mitochondria, L23 in ...
 3-109 3.88e-33

Ribosomal protein uL14; Ribosomal protein uL14 (L14 in bacteria and mitochondria, L23 in eukaryotes, L38 in fungal mitochondria) is part of the large ribosomal subunit, located between the centers of activity for peptidyl transferase and GTPase. uL14 has an "all beta" fold that binds 23S rRNA. Ribosomal proteins, which are components of ribosomal subunits, are RNA-binding proteins that might have multiple extra ribosomal functions and may be involved in tumorigenesis in mammals.


:

Pssm-ID: 466774  Cd Length: 114  Bit Score: 111.39  E-value: 3.88e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926794703   3 PKGAFLRVVDNSGARVGQVI----WTRFSAAKLGSIVKVAIKEAK-GGKVAAGQMKKAVVVETKYPTRRPNGAHFQFLRN 77
Cdd:cd00337    1 QVGTRLNVADNSGAKKVKCIkvlgKKGRRYAGVGDIIVVSVKKAKpEKKVKKGEVVKAVIVRTKKEIRRKDGSYIRFDDN 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 926794703  78 SCVLLNEKGAPIGSRMRSLLTYEFGKPRWKRL 109
Cdd:cd00337   81 AVVLINKKGEPLGTRIFGPVARELRAKKFPKI 112
 
Name Accession Description Interval E-value
Ribosomal_uL14 cd00337
Ribosomal protein uL14; Ribosomal protein uL14 (L14 in bacteria and mitochondria, L23 in ...
 3-109 3.88e-33

Ribosomal protein uL14; Ribosomal protein uL14 (L14 in bacteria and mitochondria, L23 in eukaryotes, L38 in fungal mitochondria) is part of the large ribosomal subunit, located between the centers of activity for peptidyl transferase and GTPase. uL14 has an "all beta" fold that binds 23S rRNA. Ribosomal proteins, which are components of ribosomal subunits, are RNA-binding proteins that might have multiple extra ribosomal functions and may be involved in tumorigenesis in mammals.


Pssm-ID: 466774  Cd Length: 114  Bit Score: 111.39  E-value: 3.88e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926794703   3 PKGAFLRVVDNSGARVGQVI----WTRFSAAKLGSIVKVAIKEAK-GGKVAAGQMKKAVVVETKYPTRRPNGAHFQFLRN 77
Cdd:cd00337    1 QVGTRLNVADNSGAKKVKCIkvlgKKGRRYAGVGDIIVVSVKKAKpEKKVKKGEVVKAVIVRTKKEIRRKDGSYIRFDDN 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 926794703  78 SCVLLNEKGAPIGSRMRSLLTYEFGKPRWKRL 109
Cdd:cd00337   81 AVVLINKKGEPLGTRIFGPVARELRAKKFPKI 112
Ribosomal_L14 pfam00238
Ribosomal protein L14p/L23e;
3-112 3.48e-29

Ribosomal protein L14p/L23e;


Pssm-ID: 425547  Cd Length: 119  Bit Score: 101.70  E-value: 3.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926794703    3 PKGAFLRVVDNSGARVGQVI----WTRFSAAKLGSIVKVAIKEAK-GGKVAAGQMKKAVVVETKYPTRRPNGAHFQFLRN 77
Cdd:pfam00238   1 QVGTRLNVADNSGAKEVMCIkvlgGSGRRYASVGDIIVVSVKKAKpNGKVKKGDVVKAVVVRTKKEIRRPDGSYIRFDDN 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 926794703   78 SCVLLNEKGAPIGSRMRSLLTYEFGKPRWKRLSML 112
Cdd:pfam00238  81 AAVLINDKGEPKGTRIFGPVARELREKKFPKIVSL 115
rplN_bact TIGR01067
ribosomal protein L14, bacterial/organelle; This model distinguishes bacterial and most ...
 1-92 1.51e-23

ribosomal protein L14, bacterial/organelle; This model distinguishes bacterial and most organellar examples of ribosomal protein L14 from all archaeal and eukaryotic forms. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273426  Cd Length: 122  Bit Score: 87.37  E-value: 1.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926794703    1 MIPKGAFLRVVDNSGARVGQVIWT----RFSAAKLGSIVKVAIKEA-KGGKVAAGQMKKAVVVETKYPTRRPNGAHFQFL 75
Cdd:TIGR01067   1 MIQQQSRLNVADNSGAKKVQCIKVlggsPRRYATVGDVIVVVVKDAiPNGKVKKGDVVKAVIVRTKKGVRRKDGSYIRFD 80

                          90
                  ....*....|....*..
gi 926794703   76 RNSCVLLNEKGAPIGSR 92
Cdd:TIGR01067  81 DNACVLINKNKEPRGTR 97
rpl14p PRK08571
50S ribosomal protein L14P; Reviewed
 2-94 1.32e-15

50S ribosomal protein L14P; Reviewed


Pssm-ID: 181478  Cd Length: 132  Bit Score: 67.24  E-value: 1.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926794703   2 IPKGAFLRVVDNSGARVGQVI--------WTRFSAAKLGSIVKVAIKeaKGGKVAAGQMKKAVVVETKYPTRRPNGAHFQ 73
Cdd:PRK08571  12 LPVGARLVCADNTGAKEVEIIsvkgykgvKRRLPKAGVGDMVVVSVK--KGTPEMRKQVLRAVVVRQRKEYRRPDGTRVK 89

                         90       100
                 ....*....|....*....|.
gi 926794703  74 FLRNSCVLLNEKGAPIGSRMR 94
Cdd:PRK08571  90 FEDNAAVIVTPEGTPKGTEIK 110
 
Name Accession Description Interval E-value
Ribosomal_uL14 cd00337
Ribosomal protein uL14; Ribosomal protein uL14 (L14 in bacteria and mitochondria, L23 in ...
 3-109 3.88e-33

Ribosomal protein uL14; Ribosomal protein uL14 (L14 in bacteria and mitochondria, L23 in eukaryotes, L38 in fungal mitochondria) is part of the large ribosomal subunit, located between the centers of activity for peptidyl transferase and GTPase. uL14 has an "all beta" fold that binds 23S rRNA. Ribosomal proteins, which are components of ribosomal subunits, are RNA-binding proteins that might have multiple extra ribosomal functions and may be involved in tumorigenesis in mammals.


Pssm-ID: 466774  Cd Length: 114  Bit Score: 111.39  E-value: 3.88e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926794703   3 PKGAFLRVVDNSGARVGQVI----WTRFSAAKLGSIVKVAIKEAK-GGKVAAGQMKKAVVVETKYPTRRPNGAHFQFLRN 77
Cdd:cd00337    1 QVGTRLNVADNSGAKKVKCIkvlgKKGRRYAGVGDIIVVSVKKAKpEKKVKKGEVVKAVIVRTKKEIRRKDGSYIRFDDN 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 926794703  78 SCVLLNEKGAPIGSRMRSLLTYEFGKPRWKRL 109
Cdd:cd00337   81 AVVLINKKGEPLGTRIFGPVARELRAKKFPKI 112
Ribosomal_L14 pfam00238
Ribosomal protein L14p/L23e;
3-112 3.48e-29

Ribosomal protein L14p/L23e;


Pssm-ID: 425547  Cd Length: 119  Bit Score: 101.70  E-value: 3.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926794703    3 PKGAFLRVVDNSGARVGQVI----WTRFSAAKLGSIVKVAIKEAK-GGKVAAGQMKKAVVVETKYPTRRPNGAHFQFLRN 77
Cdd:pfam00238   1 QVGTRLNVADNSGAKEVMCIkvlgGSGRRYASVGDIIVVSVKKAKpNGKVKKGDVVKAVVVRTKKEIRRPDGSYIRFDDN 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 926794703   78 SCVLLNEKGAPIGSRMRSLLTYEFGKPRWKRLSML 112
Cdd:pfam00238  81 AAVLINDKGEPKGTRIFGPVARELREKKFPKIVSL 115
rplN_bact TIGR01067
ribosomal protein L14, bacterial/organelle; This model distinguishes bacterial and most ...
 1-92 1.51e-23

ribosomal protein L14, bacterial/organelle; This model distinguishes bacterial and most organellar examples of ribosomal protein L14 from all archaeal and eukaryotic forms. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273426  Cd Length: 122  Bit Score: 87.37  E-value: 1.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926794703    1 MIPKGAFLRVVDNSGARVGQVIWT----RFSAAKLGSIVKVAIKEA-KGGKVAAGQMKKAVVVETKYPTRRPNGAHFQFL 75
Cdd:TIGR01067   1 MIQQQSRLNVADNSGAKKVQCIKVlggsPRRYATVGDVIVVVVKDAiPNGKVKKGDVVKAVIVRTKKGVRRKDGSYIRFD 80

                          90
                  ....*....|....*..
gi 926794703   76 RNSCVLLNEKGAPIGSR 92
Cdd:TIGR01067  81 DNACVLINKNKEPRGTR 97
rpl14p PRK08571
50S ribosomal protein L14P; Reviewed
 2-94 1.32e-15

50S ribosomal protein L14P; Reviewed


Pssm-ID: 181478  Cd Length: 132  Bit Score: 67.24  E-value: 1.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926794703   2 IPKGAFLRVVDNSGARVGQVI--------WTRFSAAKLGSIVKVAIKeaKGGKVAAGQMKKAVVVETKYPTRRPNGAHFQ 73
Cdd:PRK08571  12 LPVGARLVCADNTGAKEVEIIsvkgykgvKRRLPKAGVGDMVVVSVK--KGTPEMRKQVLRAVVVRQRKEYRRPDGTRVK 89

                         90       100
                 ....*....|....*....|.
gi 926794703  74 FLRNSCVLLNEKGAPIGSRMR 94
Cdd:PRK08571  90 FEDNAAVIVTPEGTPKGTEIK 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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