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Conserved domains on  [gi|852774980|ref|XP_012880611|]
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PREDICTED: lymphocyte antigen 6A-2/6E-1-like [Dipodomys ordii]

Protein Classification

Ly-6/uPAR domain-containing protein; Ly-6/uPAR domain-containing protein; acrosomal protein SP-10; acrosomal protein SP-10( domain architecture ID 10639047)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2); LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2); acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle; acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 19-101 5.92e-33

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467071  Cd Length: 83  Bit Score: 110.88  E-value: 5.92e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980  19 QSLQCYQCVGATQDSTCKQSTCPFPKGVCVTQEVGMAMGS--RKMKNKFCLPTCPKGKNMSiknIPLIGKMIHSKTSCCS 96
Cdd:cd23541    1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSqrVKLKNKFCLPFCPKNLYFL---EEILGTTVNVKTSCCK 77


                 ....*
gi 852774980  97 EDLCN 101
Cdd:cd23541   78 EDLCN 82
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 19-101 5.92e-33

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 110.88  E-value: 5.92e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980  19 QSLQCYQCVGATQDSTCKQSTCPFPKGVCVTQEVGMAMGS--RKMKNKFCLPTCPKGKNMSiknIPLIGKMIHSKTSCCS 96
Cdd:cd23541    1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSqrVKLKNKFCLPFCPKNLYFL---EEILGTTVNVKTSCCK 77


                 ....*
gi 852774980  97 EDLCN 101
Cdd:cd23541   78 EDLCN 82
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-105 6.45e-10

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 52.15  E-value: 6.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980    21 LQCYQCVGATQDSTCKQSTCPFPKGVCVTQEVGMAMGSR---KMKNKFCLPTCPKgknmsiKNIPLIGKMIHS-KTSCCS 96
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISDSRgsvVYKGCATSPICPG------SHGYEINLTIAFlKVSCCQ 74


                   ....*....
gi 852774980    97 EDLCNLGVP 105
Cdd:smart00134  75 TDLCNAAGP 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-101 9.09e-08

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 46.38  E-value: 9.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980   23 CYQCVGATQDSTCKQSTCPFPKGVCVTQEVGMAMGS--RKMKNKFCL-PTCPKGKNMSIKnipliGKMIHSKTSCCSEDL 99
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNlrGTVVSKGCArSSCPRLLSDFIN-----GGIISVSESCCQSDL 75


                  ..
gi 852774980  100 CN 101
Cdd:pfam00021  76 CN 77
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 19-101 5.92e-33

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 110.88  E-value: 5.92e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980  19 QSLQCYQCVGATQDSTCKQSTCPFPKGVCVTQEVGMAMGS--RKMKNKFCLPTCPKGKNMSiknIPLIGKMIHSKTSCCS 96
Cdd:cd23541    1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSqrVKLKNKFCLPFCPKNLYFL---EEILGTTVNVKTSCCK 77


                 ....*
gi 852774980  97 EDLCN 101
Cdd:cd23541   78 EDLCN 82
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-105 6.45e-10

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 52.15  E-value: 6.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980    21 LQCYQCVGATQDSTCKQSTCPFPKGVCVTQEVGMAMGSR---KMKNKFCLPTCPKgknmsiKNIPLIGKMIHS-KTSCCS 96
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISDSRgsvVYKGCATSPICPG------SHGYEINLTIAFlKVSCCQ 74


                   ....*....
gi 852774980    97 EDLCNLGVP 105
Cdd:smart00134  75 TDLCNAAGP 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-101 9.09e-08

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 46.38  E-value: 9.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980   23 CYQCVGATQDSTCKQSTCPFPKGVCVTQEVGMAMGS--RKMKNKFCL-PTCPKGKNMSIKnipliGKMIHSKTSCCSEDL 99
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNlrGTVVSKGCArSSCPRLLSDFIN-----GGIISVSESCCQSDL 75


                  ..
gi 852774980  100 CN 101
Cdd:pfam00021  76 CN 77
TFP_LU_ECD_Ly6L cd23551
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ...
 20-101 2.73e-07

extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467081  Cd Length: 86  Bit Score: 45.09  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980  20 SLQCYQCVGATQDSTCKQSTCPFPKGVCVTQEVGMAMGSRKMK--NKFCLPTCPKGkNMSIKNIPLIGKMIHSKTSCCSE 97
Cdd:cd23551    1 NLKCYQCFKVSSDEDCKPDQCAPSEIVCISNEVVLYVGTKVRVliSKRCAPRCPNT-NSRCEWSPGTQVIGSITRTCCSQ 79


                 ....
gi 852774980  98 DLCN 101
Cdd:cd23551   80 SLCN 83
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 20-101 5.42e-05

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 39.24  E-value: 5.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980  20 SLQCYQCVGATQDSTC-KQSTCPFPKGVCVTQEVGMAMGSRKMKN--KFCLPTCPKGKNMSIKnipligkmIHSKTSCCS 96
Cdd:cd23575    2 SLKCYTCVSAHSNSDClTETNCSSSDTYCKTLVASASGGSGSLTTitKWCASSCTPSTRTVEG--------TKVTVSCCQ 73


                 ....*
gi 852774980  97 EDLCN 101
Cdd:cd23575   74 TDLCN 78
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 20-101 1.73e-04

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467103  Cd Length: 78  Bit Score: 37.81  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980  20 SLQCYQCVGATQDSTCKQST-CPFPKGVCVTqEVGMAMGSRKMKNKFCLPTCpkgkNMSIKNIPLIGKMIhsktSCCSED 98
Cdd:cd23573    2 SLQCYTCKAQLSNSNCQTETpCRENAKACKT-DVIRAVGLLKVISKECSSSC----TEDYQDYFVGKRNI----TCCSTD 72


                 ...
gi 852774980  99 LCN 101
Cdd:cd23573   73 LCN 75
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 20-101 1.30e-03

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 35.41  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980  20 SLQCYQCVGATQDSTCKQST-CPFPKGVCVT--QEVGMAMGSRKMKNKFCLPTCP-KGKNMSIKNIpligkmihsKTSCC 95
Cdd:cd23543    2 SLYCYTCENQSSNWNCLKPTkCSDNDKYCVTtvASGGTGSSSGVRITKKCSPKCPeTNVNIGIASV---------STSCC 72


                 ....*.
gi 852774980  96 SEDLCN 101
Cdd:cd23543   73 QSSLCN 78
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 21-101 2.05e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 34.77  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980  21 LQCYQCVGATQDSTCKQS----TCPFPKGVCVTQeVGMAMGSRKMKNKFCLPTCPKGKNMSIKNIpliGKMIHSKTSCCS 96
Cdd:cd00117    1 LKCYQCNSSNDPNCCNSSptlvTCSSPETFCRKI-VGKVGGGETLVIRGCATECECGCTECCSGT---GTSGTTCTSCCD 76


                 ....*
gi 852774980  97 EDLCN 101
Cdd:cd00117   77 TDLCN 81
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 18-101 4.35e-03

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 33.93  E-value: 4.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852774980  18 AQSLQCYQCVGatqDSTCKQS-TCPFPKGVCVTQEVgmAMGSRKMKNKFCLPTCPKGKNMSIKNipligkMIHSKTSCCS 96
Cdd:cd23542    3 ANALQCHVCNS---SSNCTNPvNCEGSERYCKTTTV--VQPSGNLVKKGCAETCPPSTSRQQVG------SGISSVTCCQ 71


                 ....*
gi 852774980  97 EDLCN 101
Cdd:cd23542   72 GDLCN 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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