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Conserved domains on  [gi|795297502|ref|XP_011923924|]
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PREDICTED: importin subunit alpha-5 isoform X1 [Cercocebus atys]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
25-455 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 568.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502  25 DMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIV 104
Cdd:COG5064   75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVV 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 105 IQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKS 183
Cdd:COG5064  154 VDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKN 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 184 PPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIV 263
Cdd:COG5064  234 PPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIV 313

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 264 TGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAI 343
Cdd:COG5064  314 TGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAI 393

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 344 TNATSGGS--AEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIE 421
Cdd:COG5064  394 SNATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIH 473

                        410       420       430
                 ....*....|....*....|....*....|....
gi 795297502 422 FLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQ 455
Cdd:COG5064  474 GLQDSVNRTIYDKAYSIIEKFFGEEDAVDELAPE 507
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
25-455 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 568.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502  25 DMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIV 104
Cdd:COG5064   75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVV 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 105 IQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKS 183
Cdd:COG5064  154 VDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKN 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 184 PPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIV 263
Cdd:COG5064  234 PPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIV 313

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 264 TGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAI 343
Cdd:COG5064  314 TGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAI 393

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 344 TNATSGGS--AEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIE 421
Cdd:COG5064  394 SNATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIH 473

                        410       420       430
                 ....*....|....*....|....*....|....
gi 795297502 422 FLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQ 455
Cdd:COG5064  474 GLQDSVNRTIYDKAYSIIEKFFGEEDAVDELAPE 507
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 410-455 8.98e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 79.56  E-value: 8.98e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 795297502  410 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE--DSSIAPQ 455
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEedDENLAPE 49
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 97-136 1.35e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 53.20  E-value: 1.35e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 795297502    97 NSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 136
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
25-455 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 568.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502  25 DMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIV 104
Cdd:COG5064   75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVV 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 105 IQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKS 183
Cdd:COG5064  154 VDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKN 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 184 PPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIV 263
Cdd:COG5064  234 PPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIV 313

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 264 TGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAI 343
Cdd:COG5064  314 TGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAI 393

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 344 TNATSGGS--AEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIE 421
Cdd:COG5064  394 SNATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIH 473

                        410       420       430
                 ....*....|....*....|....*....|....
gi 795297502 422 FLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQ 455
Cdd:COG5064  474 GLQDSVNRTIYDKAYSIIEKFFGEEDAVDELAPE 507
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 410-455 8.98e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 79.56  E-value: 8.98e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 795297502  410 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE--DSSIAPQ 455
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEedDENLAPE 49
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 97-136 1.41e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 59.01  E-value: 1.41e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 795297502   97 NSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 136
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 97-136 1.35e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 53.20  E-value: 1.35e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 795297502    97 NSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 136
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 308-348 7.27e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.60  E-value: 7.27e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 795297502  308 NRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATS 348
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
107-262 1.04e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.78  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 107 AGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTmcrdyvldcniLPPLLQLFSKQNRLTmTRNAVWALSNLcrgKSPpp 186
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAAARALGRLGDPRA-----------VPALLEALKDPDPEV-RAAAAEALGRI---GDP-- 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795297502 187 efAKVSPCLNVLSWllfvSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHNDYKVVSPALRAVGNI 262
Cdd:COG1413   78 --EAVPALIAALKD----EDPEVRRAAAEALGRLGD------PAAVPA-----LLEALKDPDWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 139-180 1.23e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 1.23e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 795297502  139 STMCRDYVLDCNILPPLLQLFSKQNrLTMTRNAVWALSNLCR 180
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPD-EEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 224-264 2.86e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.68  E-value: 2.86e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 795297502  224 PNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVT 264
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 351-391 5.92e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 5.92e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 795297502  351 SAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILR 391
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 224-263 1.10e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.11  E-value: 1.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 795297502   224 PNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIV 263
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 82-135 8.31e-06

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 43.12  E-value: 8.31e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 795297502   82 LQFESAWVLTNIASGNSLQTRIVIQAgAVPIFIELLSSEFEDVQEQAVWALGNI 135
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 67-176 1.14e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.48  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502   67 VARFVEFLKRKENCTLQFESAWVLTNIASgnslqtriviqAGAVPIFIELLSSEFEDVQEQAVWALGNIaGDSTMcrdyv 146
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI-GDPEA----- 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 795297502  147 ldcniLPPLLQLFSKQNRLTMTRNAVWALS 176
Cdd:pfam13646  64 -----LPALLELLRDDDDDVVRAAAAEALA 88
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 308-348 1.56e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.65  E-value: 1.56e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 795297502   308 NRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATS 348
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 351-389 2.18e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.26  E-value: 2.18e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 795297502   351 SAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENI 389
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 139-180 2.31e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 2.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 795297502   139 STMCRDYVLDCNILPPLLQLFSKQNrLTMTRNAVWALSNLCR 180
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSED-EEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
169-343 4.39e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.38  E-value: 4.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 169 RNAVWALSNLcrgkspppefaKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHND 248
Cdd:COG1413    3 RAAARALGRL-----------GDPAAVPALIAALADEDPDVRAAAARALGRLGD------PRAVPA-----LLEALKDPD 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 249 YKVVSPALRAVGNIvtGDDIQTQVILNcsalqsllhLLSSPKESIKKEACWTISNITagnraqiqtviDANIFPALISIL 328
Cdd:COG1413   61 PEVRAAAAEALGRI--GDPEAVPALIA---------ALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEAL 118

                        170
                 ....*....|....*
gi 795297502 329 QTAEFRTRKEAAWAI 343
Cdd:COG1413  119 KDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
124-262 5.06e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.38  E-value: 5.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795297502 124 VQEQAVWALGNIAGDSTmcrdyvldcniLPPLLQLFSKQNRLTMtRNAVWALSNLCRGKSPPPefakvspclnvLSWLLF 203
Cdd:COG1413    1 VRRAAARALGRLGDPAA-----------VPALIAALADEDPDVR-AAAARALGRLGDPRAVPA-----------LLEALK 57

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 795297502 204 VSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHNDYKVVSPALRAVGNI 262
Cdd:COG1413   58 DPDPEVRAAAAEALGRIGD------PEAVPA-----LIAALKDEDPEVRRAAAEALGRL 105
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 183-222 1.59e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 1.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 795297502  183 SPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSD 222
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 53-95 2.41e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 2.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 795297502   53 PNPPIDEVIStPGVVARFVEFLKrKENCTLQFESAWVLTNIAS 95
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 21-43 2.45e-03

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 36.75  E-value: 2.45e-03
                          10        20
                  ....*....|....*....|...
gi 795297502   21 VITSDMIEMIFSKSPEQQLSATQ 43
Cdd:pfam01749  57 ESLPEMVQGVNSDDPELQLEATQ 79
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 292-345 5.66e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.04  E-value: 5.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 795297502  292 SIKKEACWTISNITAGNRAQIQTVIDaNIFPALISILQTAEFRTRKEAAWAITN 345
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVP-ELLPALLPLLNDDSDLVREAAAWALGR 54
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 124-178 7.31e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 34.65  E-value: 7.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 795297502  124 VQEQAVWALGNIAGDSTM-CRDYVLDcnILPPLLQLfSKQNRLTMTRNAVWALSNL 178
Cdd:pfam13513   3 VREAAALALGSLAEGGPDlLAPAVPE--LLPALLPL-LNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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