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Conserved domains on  [gi|768930219|ref|XP_011605957|]
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fin bud initiation factor-like [Takifugu rubripes]

Protein Classification

Fibin domain-containing protein( domain architecture ID 11239385)

Fibin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibin pfam15819
Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the ...
 46-233 5.64e-102

Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the lateral plate mesoderm of presumptive pectoral fin bud regions. It acts as a signal molecule for the expression of Tbx5, a gene involved in the specification of fore-limb identity. Fibin is found to be expressed in cerebellum, skeletal muscle and many other embryonic as well as adult mouse tissues, suggesting roles in both embryogenesis and in adult life. Although Fibin is routed through the endoplasmic reticulum (ER) no significant evidence for secretion is found. Fibin is post-translationally modified and forms dimers when expressed heterologously and its expression is regulated by a number of cellular signalling pathways.


:

Pssm-ID: 406297  Cd Length: 189  Bit Score: 293.58  E-value: 5.64e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768930219   46 PAVYSGPLQAEITNGTFHHFFVPDGDYEETEDLEQCQMLFKFSDMHPCGGSEERDSAVRDDLIIAKLQAEDAARLLEGIG 125
Cdd:pfam15819   2 GGYFGGPLPPEMSNGTLHHFFVPDGDYEENDDPEKCQLLFKVSDRRPCGAEEDSDAVLRDDFIILKRQVEDAARVLEGIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768930219  126 RTVEQDLDGEDTYGKFLQRELSQIGEAFSSVDKSLMELEGKFKQSQETELREEQQLNGYVMKQVGDIRDTLRKTTDISAG 205
Cdd:pfam15819  82 KSISYDLDGEESYGKYLRRESQQIGEAFSVSDKSLEELEKKFKQSQEEEREEEQRLGDDFLQMVDHRRALLEETLDISGG 161

                         170       180
                  ....*....|....*....|....*...
gi 768930219  206 LKDKQELLSLIVRSHGTRLSRLKTEYLN 233
Cdd:pfam15819 162 LRDKHELLSLIVRSHGTRLSRLKNEYLK 189
 
Name Accession Description Interval E-value
Fibin pfam15819
Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the ...
 46-233 5.64e-102

Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the lateral plate mesoderm of presumptive pectoral fin bud regions. It acts as a signal molecule for the expression of Tbx5, a gene involved in the specification of fore-limb identity. Fibin is found to be expressed in cerebellum, skeletal muscle and many other embryonic as well as adult mouse tissues, suggesting roles in both embryogenesis and in adult life. Although Fibin is routed through the endoplasmic reticulum (ER) no significant evidence for secretion is found. Fibin is post-translationally modified and forms dimers when expressed heterologously and its expression is regulated by a number of cellular signalling pathways.


Pssm-ID: 406297  Cd Length: 189  Bit Score: 293.58  E-value: 5.64e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768930219   46 PAVYSGPLQAEITNGTFHHFFVPDGDYEETEDLEQCQMLFKFSDMHPCGGSEERDSAVRDDLIIAKLQAEDAARLLEGIG 125
Cdd:pfam15819   2 GGYFGGPLPPEMSNGTLHHFFVPDGDYEENDDPEKCQLLFKVSDRRPCGAEEDSDAVLRDDFIILKRQVEDAARVLEGIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768930219  126 RTVEQDLDGEDTYGKFLQRELSQIGEAFSSVDKSLMELEGKFKQSQETELREEQQLNGYVMKQVGDIRDTLRKTTDISAG 205
Cdd:pfam15819  82 KSISYDLDGEESYGKYLRRESQQIGEAFSVSDKSLEELEKKFKQSQEEEREEEQRLGDDFLQMVDHRRALLEETLDISGG 161

                         170       180
                  ....*....|....*....|....*...
gi 768930219  206 LKDKQELLSLIVRSHGTRLSRLKTEYLN 233
Cdd:pfam15819 162 LRDKHELLSLIVRSHGTRLSRLKNEYLK 189
 
Name Accession Description Interval E-value
Fibin pfam15819
Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the ...
 46-233 5.64e-102

Fin bud initiation factor homolog; Fibin is a family of eukaryotic proteins expressed in the lateral plate mesoderm of presumptive pectoral fin bud regions. It acts as a signal molecule for the expression of Tbx5, a gene involved in the specification of fore-limb identity. Fibin is found to be expressed in cerebellum, skeletal muscle and many other embryonic as well as adult mouse tissues, suggesting roles in both embryogenesis and in adult life. Although Fibin is routed through the endoplasmic reticulum (ER) no significant evidence for secretion is found. Fibin is post-translationally modified and forms dimers when expressed heterologously and its expression is regulated by a number of cellular signalling pathways.


Pssm-ID: 406297  Cd Length: 189  Bit Score: 293.58  E-value: 5.64e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768930219   46 PAVYSGPLQAEITNGTFHHFFVPDGDYEETEDLEQCQMLFKFSDMHPCGGSEERDSAVRDDLIIAKLQAEDAARLLEGIG 125
Cdd:pfam15819   2 GGYFGGPLPPEMSNGTLHHFFVPDGDYEENDDPEKCQLLFKVSDRRPCGAEEDSDAVLRDDFIILKRQVEDAARVLEGIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768930219  126 RTVEQDLDGEDTYGKFLQRELSQIGEAFSSVDKSLMELEGKFKQSQETELREEQQLNGYVMKQVGDIRDTLRKTTDISAG 205
Cdd:pfam15819  82 KSISYDLDGEESYGKYLRRESQQIGEAFSVSDKSLEELEKKFKQSQEEEREEEQRLGDDFLQMVDHRRALLEETLDISGG 161

                         170       180
                  ....*....|....*....|....*...
gi 768930219  206 LKDKQELLSLIVRSHGTRLSRLKTEYLN 233
Cdd:pfam15819 162 LRDKHELLSLIVRSHGTRLSRLKNEYLK 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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