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Conserved domains on  [gi|768024839|ref|XP_011528481|]
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splicing regulator ARVCF isoform X3 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 11997871)

armadillo/beta-catenin-like repeat-containing protein similar to splicing regulator ARVCF, an armadillo repeat protein deleted in velo-cardio-facial syndrome

CATH:  1.25.10.10
Gene Ontology:  GO:0098609|GO:0005515
PubMed:  12946625|9770300|9298899|20688255
SCOP:  3000116

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 432-473 7.81e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 49.35  E-value: 7.81e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 768024839   432 DTDNKAAIRDCGGVPALVRLLRaARDNEVRELVTGTLWNLSS 473
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK-SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 389-428 2.25e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 2.25e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 768024839  389 NEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLS 428
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-726 1.12e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.88  E-value: 1.12e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 768024839   691 RATVRKERGLPVLVELLQSETDKVVRAVAIALRNLS 726
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 645-681 6.18e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 6.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 768024839  645 ELLYQPEVVRLYLSLLTeSRNFNTLEAAAGALQNLSA 681
Cdd:pfam00514   6 QAVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
 
Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 432-473 7.81e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 49.35  E-value: 7.81e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 768024839   432 DTDNKAAIRDCGGVPALVRLLRaARDNEVRELVTGTLWNLSS 473
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK-SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 432-473 8.14e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 49.38  E-value: 8.14e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768024839  432 DTDNKAAIRDCGGVPALVRLLRAArDNEVRELVTGTLWNLSS 473
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 389-428 2.25e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 2.25e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 768024839  389 NEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLS 428
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 389-429 4.38e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.04  E-value: 4.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 768024839   389 NEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSY 429
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-726 1.12e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.88  E-value: 1.12e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 768024839   691 RATVRKERGLPVLVELLQSETDKVVRAVAIALRNLS 726
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 360-473 2.41e-05

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 48.56  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024839  360 LPEVLAMLRHPVDPVKANAAAYLQHLCFENEgvkRRVRQLRG--LPLLVALLDHPRAEVRRRACGALRNLSYGRDTDN-- 435
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEED---LRVKVLLGgcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDHvg 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 768024839  436 -KAAIRDcGGVPALVRLLRA--ARDNEVRELVTGTLWNLSS 473
Cdd:PLN03200  137 sKIFSTE-GVVPSLWDQLQPgnKQDKVVEGLLTGALRNLCG 176
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-726 1.68e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.75  E-value: 1.68e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 768024839  691 RATVRKERGLPVLVELLQSETDKVVRAVAIALRNLS 726
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT COG1413
HEAT repeat [General function prediction only];
354-471 1.81e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024839 354 RWRDPE-LPEVLAMLRHPVDPVKANAAAYLqhlcfenegvkRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLsygrd 432
Cdd:COG1413   42 RLGDPRaVPALLEALKDPDPEVRAAAAEAL-----------GRIGDPEAVPALIAALKDEDPEVRRAAAEALGRL----- 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 768024839 433 tDNKAAirdcggVPALVRLLRAArDNEVRELVTGTLWNL 471
Cdd:COG1413  106 -GDPAA------VPALLEALKDP-DWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 645-681 6.18e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 6.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 768024839  645 ELLYQPEVVRLYLSLLTeSRNFNTLEAAAGALQNLSA 681
Cdd:pfam00514   6 QAVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
 
Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 432-473 7.81e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 49.35  E-value: 7.81e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 768024839   432 DTDNKAAIRDCGGVPALVRLLRaARDNEVRELVTGTLWNLSS 473
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK-SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 432-473 8.14e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 49.38  E-value: 8.14e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 768024839  432 DTDNKAAIRDCGGVPALVRLLRAArDNEVRELVTGTLWNLSS 473
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 389-428 2.25e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 2.25e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 768024839  389 NEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLS 428
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 389-429 4.38e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.04  E-value: 4.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 768024839   389 NEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSY 429
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-726 1.12e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.88  E-value: 1.12e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 768024839   691 RATVRKERGLPVLVELLQSETDKVVRAVAIALRNLS 726
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 360-473 2.41e-05

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 48.56  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024839  360 LPEVLAMLRHPVDPVKANAAAYLQHLCFENEgvkRRVRQLRG--LPLLVALLDHPRAEVRRRACGALRNLSYGRDTDN-- 435
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEED---LRVKVLLGgcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDHvg 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 768024839  436 -KAAIRDcGGVPALVRLLRA--ARDNEVRELVTGTLWNLSS 473
Cdd:PLN03200  137 sKIFSTE-GVVPSLWDQLQPgnKQDKVVEGLLTGALRNLCG 176
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-726 1.68e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.75  E-value: 1.68e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 768024839  691 RATVRKERGLPVLVELLQSETDKVVRAVAIALRNLS 726
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT COG1413
HEAT repeat [General function prediction only];
354-471 1.81e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024839 354 RWRDPE-LPEVLAMLRHPVDPVKANAAAYLqhlcfenegvkRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLsygrd 432
Cdd:COG1413   42 RLGDPRaVPALLEALKDPDPEVRAAAAEAL-----------GRIGDPEAVPALIAALKDEDPEVRRAAAEALGRL----- 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 768024839 433 tDNKAAirdcggVPALVRLLRAArDNEVRELVTGTLWNL 471
Cdd:COG1413  106 -GDPAA------VPALLEALKDP-DWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 645-681 6.18e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 6.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 768024839  645 ELLYQPEVVRLYLSLLTeSRNFNTLEAAAGALQNLSA 681
Cdd:pfam00514   6 QAVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 360-462 6.84e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.93  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024839  360 LPEVLAMLRHPVDP-VKANAAAYLQHLCFEnegvkrrvrqlRGLPLLVALLDHPRAEVRRRACGALrnlsygrdtdnkAA 438
Cdd:pfam13646   1 LPALLQALLRDPDPeVRAAAIRALGRIGDP-----------EAVPALLELLKDEDPAVRRAAAEAL------------GK 57

                          90       100
                  ....*....|....*....|....
gi 768024839  439 IRDCGGVPALVRLLRAARDNEVRE 462
Cdd:pfam13646  58 IGDPEALPALLELLRDDDDDVVRA 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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