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Conserved domains on  [gi|768015862|ref|XP_011526844|]
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phosphatidylinositol glycan anchor biosynthesis class U protein isoform X2 [Homo sapiens]

Protein Classification

PIG-U family protein( domain architecture ID 10535524)

PIG-U family protein similar to human phosphatidylinositol glycan anchor biosynthesis class U protein and Saccharomyces cerevisiae GPI transamidase component GAB1 (Cdc91p), which attach GPI-anchors to proteins

Gene Ontology:  GO:0042765|GO:0016255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PIG-U pfam06728
GPI transamidase subunit PIG-U; Many eukaryotic proteins are anchored to the cell surface via ...
 2-178 1.54e-63

GPI transamidase subunit PIG-U; Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.


:

Pssm-ID: 429085  Cd Length: 375  Bit Score: 201.69  E-value: 1.54e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015862    2 KSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINV 81
Cdd:pfam06728 199 LSSNSLSKFLSFLLLFLLTLAALLLASFLITGSWDFLDATYGFILTFEDLTPNLGLWWYFFTEMFDHFRPFFLFVFNLHP 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015862   82 FFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWI 161
Cdd:pfam06728 279 FIYILPLTIRLRKQPLFALTLLLGLISIFKPYPTLGDLGLYLSLLPLFRHLFPYMRYSFLIGLTLLVALLLSPIFYHLWI 358

                         170
                  ....*....|....*..
gi 768015862  162 YAGSANSNFFYAITLTF 178
Cdd:pfam06728 359 VLGSGNANFFYAITLVY 375
 
Name Accession Description Interval E-value
PIG-U pfam06728
GPI transamidase subunit PIG-U; Many eukaryotic proteins are anchored to the cell surface via ...
 2-178 1.54e-63

GPI transamidase subunit PIG-U; Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.


Pssm-ID: 429085  Cd Length: 375  Bit Score: 201.69  E-value: 1.54e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015862    2 KSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINV 81
Cdd:pfam06728 199 LSSNSLSKFLSFLLLFLLTLAALLLASFLITGSWDFLDATYGFILTFEDLTPNLGLWWYFFTEMFDHFRPFFLFVFNLHP 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015862   82 FFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWI 161
Cdd:pfam06728 279 FIYILPLTIRLRKQPLFALTLLLGLISIFKPYPTLGDLGLYLSLLPLFRHLFPYMRYSFLIGLTLLVALLLSPIFYHLWI 358

                         170
                  ....*....|....*..
gi 768015862  162 YAGSANSNFFYAITLTF 178
Cdd:pfam06728 359 VLGSGNANFFYAITLVY 375
 
Name Accession Description Interval E-value
PIG-U pfam06728
GPI transamidase subunit PIG-U; Many eukaryotic proteins are anchored to the cell surface via ...
 2-178 1.54e-63

GPI transamidase subunit PIG-U; Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.


Pssm-ID: 429085  Cd Length: 375  Bit Score: 201.69  E-value: 1.54e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015862    2 KSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINV 81
Cdd:pfam06728 199 LSSNSLSKFLSFLLLFLLTLAALLLASFLITGSWDFLDATYGFILTFEDLTPNLGLWWYFFTEMFDHFRPFFLFVFNLHP 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768015862   82 FFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWI 161
Cdd:pfam06728 279 FIYILPLTIRLRKQPLFALTLLLGLISIFKPYPTLGDLGLYLSLLPLFRHLFPYMRYSFLIGLTLLVALLLSPIFYHLWI 358

                         170
                  ....*....|....*..
gi 768015862  162 YAGSANSNFFYAITLTF 178
Cdd:pfam06728 359 VLGSGNANFFYAITLVY 375
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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