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Conserved domains on  [gi|767996348|ref|XP_011523729|]
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galanin receptor type 2 isoform X1 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
26-246 5.09e-141

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15097:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 279  Bit Score: 399.97  E-value: 5.09e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15097   59 ATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLS 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVA 185
Cdd:cd15097  139 YYDLIDYANSTVCMPGWEEARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSESKRAKRKVTKMIIIVT 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 186 ALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15097  219 ALFCLCWLPHHVVILCYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
 
Name Accession Description Interval E-value
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
26-246 5.09e-141

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 399.97  E-value: 5.09e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15097   59 ATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLS 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVA 185
Cdd:cd15097  139 YYDLIDYANSTVCMPGWEEARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSESKRAKRKVTKMIIIVT 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 186 ALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15097  219 ALFCLCWLPHHVVILCYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
25-235 4.31e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 169.79  E-value: 4.31e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348   25 WATIY-TLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:pfam00001  41 WLVYYlNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPP 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  104 LSYY--RQSQLANLTVCHPAWSAP--RRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRaKRKVTR 179
Cdd:pfam00001 121 LLFGwtLTVPEGNVTVCFIDFPEDlsKPVSYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQR-RRKALK 199
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348  180 MILIVAALFCLCWMPHHALILC-VWFGQFPLTRATYALRILSHLVSYANSCVNPIVY 235
Cdd:pfam00001 200 TLAVVVVVFILCWLPYHIVNLLdSLALDCELSRLLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
29-247 2.56e-23

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 98.31  E-value: 2.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR 108
Cdd:PHA03087  99 YILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYT 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVCHPAWSAPRRRAMDICTF---VFSYLLPVLVLGLTYARTLRYLwravdpvaAGSGARRAKRKVTRMILIVA 185
Cdd:PHA03087 179 TKKDHETLICCMFYNNKTMNWKLFINFeinIIGMLIPLTILLYCYSKILITL--------KGINKSKKNKKAIKLVLIIV 250
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 186 ALFCLCWMPHHAL-------ILCVWFGQFPLTRATYALRIlSHLVSYANSCVNPIVYALVSKHFRKGFR 247
Cdd:PHA03087 251 ILFVIFWLPFNVSvfvyslhILHFKSGCKAVKYIQYALHV-TEIISLSHCCINPLIYAFVSEFFNKHKK 318
 
Name Accession Description Interval E-value
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
26-246 5.09e-141

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 399.97  E-value: 5.09e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15097   59 ATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLS 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVA 185
Cdd:cd15097  139 YYDLIDYANSTVCMPGWEEARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSESKRAKRKVTKMIIIVT 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 186 ALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15097  219 ALFCLCWLPHHVVILCYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
26-246 4.34e-114

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 331.74  E-value: 4.34e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd14971   58 ATIYPLPGWVFGDFMCKFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLA 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQ--LANLTVCHPAW-SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMIL 182
Cdd:cd14971  138 LHRLRNytPGNRTVCSEAWpSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKRKVTRLVL 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 183 IVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14971  218 VVVVLFAACWGPIHAILLLVALGPFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
26-246 4.45e-79

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 242.71  E-value: 4.45e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15098   60 ATIYSLPEWVFGAFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAV 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQ---SQLANLTVCHPAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavDPVAAGSGARRAKRKVTRMI 181
Cdd:cd15098  140 HQDLvhhWTASNQTFCWENWPEKQqKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHK--KLKNMSKKSERSKKKTAQTV 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 182 LIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15098  218 LVVVVVFGISWLPHHIIHLWVEFGDFPLTQASFVLRITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
26-246 1.13e-61

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 198.28  E-value: 1.13e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15095   58 AALYATPSWVFGDFMCKFVNYMMQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAI 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLA---NLTVCHPAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGS-----GARRAKRK 176
Cdd:cd15095  138 YYRLEEGYwygPQTYCREVWPSKAfQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSeqlseRALRQKRK 217
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 177 VTRMILIVAALFCLCWMPHHALILC-VWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15095  218 VTRMVIVVVVLFAICWLPNHVLNLWqRFDPNFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
26-246 3.63e-60

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 194.05  E-value: 3.63e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP--- 102
Cdd:cd15096   58 ATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPvlf 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 -YLSYYRQSQLANLTVCHPAWSAPRR-RAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSG-ARRAKRKVTR 179
Cdd:cd15096  138 lHGVVSYGFSSEAYSYCTFLTEVGTAaQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGRRSAeSQRGKRRVTR 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 180 MILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15096  218 LVVVVVVVFAICWLPIHIILLLKYYGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
25-239 2.99e-56

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 183.64  E-value: 2.99e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd00637   55 SLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPL 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYRQSQLANLTVCHPAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSG------ARRAKRKV 177
Cdd:cd00637  135 LGWGVYDYGGYCCCCLCWPDLTlSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSnssrrrRRRRERKV 214
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 178 TRMILIVAALFCLCWMPHHALILCVWFGQFPlTRATYALRILSHLVSYANSCVNPIVYALVS 239
Cdd:cd00637  215 TKTLLIVVVVFLLCWLPYFILLLLDVFGPDP-SPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
29-246 1.62e-54

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 180.10  E-value: 1.62e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR 108
Cdd:cd14993   61 NVYRPWVFGEVLCKAVPYLQGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYE 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANL-------TVCHPAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGAR-------RA 173
Cdd:cd14993  141 LEEIISSepgtitiYICTEDWPSPElRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANStssrrilRS 220
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 174 KRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRI---LSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14993  221 KKKVARMLIVVVVLFALSWLPYYVLSILLDFGPLSSEESDENFLLilpFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
25-235 4.31e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 169.79  E-value: 4.31e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348   25 WATIY-TLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:pfam00001  41 WLVYYlNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPP 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  104 LSYY--RQSQLANLTVCHPAWSAP--RRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRaKRKVTR 179
Cdd:pfam00001 121 LLFGwtLTVPEGNVTVCFIDFPEDlsKPVSYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQR-RRKALK 199
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348  180 MILIVAALFCLCWMPHHALILC-VWFGQFPLTRATYALRILSHLVSYANSCVNPIVY 235
Cdd:pfam00001 200 TLAVVVVVFILCWLPYHIVNLLdSLALDCELSRLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
26-246 6.20e-50

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 167.86  E-value: 6.20e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd14970   57 ATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVII 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYR-QSQLANLTVCHPAWSAPRR---RAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGA-RRAKRKVTRM 180
Cdd:cd14970  137 FARtLQEEGGTISCNLQWPDPPDywgRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREkRRARRKVTRL 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 181 ILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14970  217 VLVVVAVFVVCWLPFHVFQIVRLLIDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
33-246 5.83e-43

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 149.69  E-value: 5.83e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPlHSRELrTPRNALAAIGLIWGLSLLFSGP------YLSY 106
Cdd:cd15207   65 GWPFGDVMCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHP-TEPKL-TNRQAFVIIVAIWVLALAIMIPqalvleVKEY 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YrQSQLANLTVCHPAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVA--AGSGARRA----KRKVTR 179
Cdd:cd15207  143 Q-FFRGQTVHICVEFWPSDEyRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGgsASREAQAAvskkKVRVIK 221
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 180 MILIVAALFCLCWMPHHALILCVWFGQFPLTRAT----YALRIlSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15207  222 MLIVVVVLFALSWLPLHTVTMLDDFGNLSPNQREvlyvYIYPI-AHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-246 5.00e-40

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 142.53  E-value: 5.00e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRElrTPRNALAAIGLIWGLSLLFSGPYLSYY---RQS 110
Cdd:cd15208   66 WFFGQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIVSLLIMIPQAIVMecsRVV 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLAN----LTVCHPAWSAPRRRAM-DICTFVFSYLLPVLVLGLTYARTLRYLWRAVDP-----------------VAAGS 168
Cdd:cd15208  144 PLANktilLTVCDERWSDSIYQKVyHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPgtssvvqrkwnkprksaVAAEE 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 169 GARRAKRKVTRMILIVAALFCLCWMPHHAL-ILCVWFGQFPLTRAT-YALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15208  224 KQLRSRRKTAKMLIVVVIMFAICYLPVHLLnILRYVFGLFTVDRETiYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
28-246 6.58e-40

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 141.26  E-value: 6.58e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL--- 104
Cdd:cd15001   59 EYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLfgq 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYRQSQLANLTV--CHPAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYartlrylwravdpvaagsgARRAKRKVTRMI 181
Cdd:cd15001  139 GLVRYESENGVTVyhCQKAWPSTLySRLYVVYLAIVIFFIPLIVMTFAY-------------------ARDTRKQVIKML 199
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 182 LIVAALFCLCWMPHHALILCVWFGQFPL--TRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15001  200 ISVVVLFAVCWGPLLIDNLLVSFDVISTlhTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
25-246 7.19e-40

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 140.78  E-value: 7.19e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd14967   55 FSAVYTLLGyWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQSQLANLTVChpAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYlwravdpvaagsgARRaKRKVTRMILI 183
Cdd:cd14967  135 LVGWRDETQPSVVDC--ECEFTPNKIYVLVSSVISFFIPLLIMIVLYARIFRV-------------ARR-ELKAAKTLAI 198
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 184 VAALFCLCWMPHHALILC-VWFGQFPLTRATYAlriLSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14967  199 IVGAFLLCWLPFFIIYLVsAFCPPDCVPPILYA---VFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
28-246 1.10e-39

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 141.20  E-value: 1.10e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTL-DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRelRTPRNALAAIGLIWGLSLLFSGPYLSY 106
Cdd:cd15203   59 IYTLtKNWPFGSILCKLVPSLQGVSIFVSTLTLTAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLLSLPLAIF 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSQLA------NLTVCHPAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYARTLRYL---WRAVDPVAAGSGARRA--- 173
Cdd:cd15203  137 QELSDVPieilpyCGYFCTESWPSSSsRLIYTISVLVLQFVIPLLIISFCYFRISLKLrkrVKKKRGKRTLSSRRRRsel 216
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 174 --KRKVTRMILIVAALFCLCWMPHHAL-ILCVWFGQFPL-TRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15203  217 rrKRRTNRLLIAMVVVFAVCWLPLNLFnLLRDFEPLPQIdGRHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-246 3.15e-39

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 139.90  E-value: 3.15e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15093   57 AASNALRHWPFGSVLCRLVLSVDGINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVV 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYR-QSQLANLTVCHPAWSAPRRR---AMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVTRMI 181
Cdd:cd15093  137 FAGtRENQDGSSACNMQWPEPAAAwsaGFIIYTFVLGFLLPLLIICLCYLLIVIKV-KSAGLRAGWQQRKRSERKVTRMV 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 182 LIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15093  216 VMVVVVFVICWLPFYVLQLVNVFVQLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
26-246 3.89e-39

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 139.71  E-value: 3.89e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP--Y 103
Cdd:cd15927   58 STIYTLDSWPFGEFLCKLSEFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPeaI 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQSQL---ANLTVCHP---AWSAPRRRAMDICTFVFSYLLPVLVLGLTY---ARTLRYLWRAVDPVAAGSGAR--R 172
Cdd:cd15927  138 FSHVVTFTLtdnQTIQICYPypqELGPNYPKIMVLLRFLVYYLIPLLIIGVFYvlmARHLIRSTRNIGSGQNQAAQRqiE 217
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 173 AKRKVTRMILIVAALFCLCWMPHHALILCVWF---GQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15927  218 ARKKVAKTVLAFVVLFAVCWLPRHVFMLWFHFapnGLVDYNAFWHVLKIVGFCLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
29-244 5.74e-39

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 138.94  E-value: 5.74e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP-YLSYY 107
Cdd:cd14982   61 LNGGWWPFGDFLCRLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPlLLLRS 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 RQSQLANLTVCHPAWSAPRRRA--MDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpVAAGSGARRAKRKVTRMILIVA 185
Cdd:cd14982  141 TIAKENNSTTCFEFLSEWLASAapIVLIALVVGFLIPLLIILVCYSLIIRALRR----RSKQSQKSVRKRKALRMILIVL 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 186 ALFCLCWMPHHA--LILCVWFGQFPL----TRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd14982  217 AVFLVCFLPYHVtrILYLLVRLSFIAdcsaRNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-244 5.80e-39

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 139.11  E-value: 5.80e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRElRTPRNALAAIGLIWGLSLLFSGPYLSYYR 108
Cdd:cd14999   59 YFLKKWYFGDVGCRLLFSLDFLTMHASIFTLTVMSTERYLAVVKPLDTVK-RSKSYRKLLAGVIWLLSLLLTLPMAIMIR 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQ-----LANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILI 183
Cdd:cd14999  138 LVTvedksGGSKRICLPTWSEESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRLPKQKVLKMIFT 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 184 VAALFCLCWMPHHALILCVWFGQFPL--TRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd14999  218 IVLVFWACFLPFWIWQLLYLYSPSLSlsPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYKE 280
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
22-246 3.33e-38

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 137.43  E-value: 3.33e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  22 NVQWATIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRelRTPRNALAAIGLIWGLSLLFS 100
Cdd:cd15390   53 NTVFNFTYLLYNdWPFGLFYCKFSNFVAITTVAASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLA 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 101 GPYLSYYRQ-----SQLANLTVCHPAWSAPRRRAMD----ICTFVFSYLLPVLVLGLTYARTLRYLWR---AVDPVAAGS 168
Cdd:cd15390  131 LPQLLYSTTetyyyYTGSERTVCFIAWPDGPNSLQDfvynIVLFVVTYFLPLIIMAVAYTRVGVELWGsktIGENTPRQL 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 169 GARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFgQFPLTRATYALRIlsHLVSY----ANSCVNPIVYALVSKHFRK 244
Cdd:cd15390  211 ESVRAKRKVVKMMIVVVVIFAICWLPYHLYFILTYL-YPDINSWKYIQQI--YLAIYwlamSNSMYNPIIYCWMNKRFRY 287

                 ..
gi 767996348 245 GF 246
Cdd:cd15390  288 GF 289
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
34-244 7.66e-38

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 135.89  E-value: 7.66e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLsYYRQSQL- 112
Cdd:cd14974   65 WPFGSVLCKLNSFVISLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYF-VFRDTVTh 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 -----ANLTVC-HPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARtlrylwravdpVAAGSGARR--AKRKVTRMILIV 184
Cdd:cd14974  144 hngrsCNLTCVeDYDLRRSRHKALTVIRFLCGFLLPLLIIAICYSV-----------IAVKLRRKRlaKSSKPLRVLLAV 212
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 185 AALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd14974  213 VVAFFLCWLPYHVFALLELVAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRK 272
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
34-246 1.68e-37

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 135.33  E-value: 1.68e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRelRTPRNALAAIGLIWGLSLLFSGP---YLSYYRQS 110
Cdd:cd15202   66 WIFGLFMCHFSNFAQYCSVHVSAYTLTAIAVDRYQAIMHPLKPR--ISKTKAKFIIAVIWTLALAFALPhaiCSKLETFK 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLT--VCHPAWSAPRR---RAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGS----GARRAKRKVTRMI 181
Cdd:cd15202  144 YSEDIVrsLCLEDWPERADlfwKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDATTeryfALRRKKKKVIKML 223
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 182 LIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15202  224 MVVVVLFALCWLPFNIYVLLLSSKPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
29-245 1.07e-36

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 133.23  E-value: 1.07e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRelRTPRNALAAIGLIWGLSLLFSGPYLSYYR 108
Cdd:cd15389   61 FVNSTWVFGKIMCHLSRFAQYCSVYVSTLTLTAIALDRHRVILHPLKPR--ITPCQGVVVIAIIWIMASCLSLPHAIYQK 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLAN-----LTVCHPAWSAPR---RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWR--AVDPVAAGSGA--RRAKRK 176
Cdd:cd15389  139 LVEFEYsnertRSRCLPSFPEPSdlfWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLrnAIGDVTTEQYVaqRRKKKK 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 177 VTRMILIVAALFCLCWMPHHALILCVWFGQFpltRATYALRILSHLVSYANSCVNPIVYALVSKHFRKG 245
Cdd:cd15389  219 TIKMLMLVVLLFAICWLPLNCYHVLLSSHPI---RSNSALFFAFHWLAMSSTCYNPFIYCWLNDSFRSE 284
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
25-246 1.31e-36

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 132.89  E-value: 1.31e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd14985   56 WATYTANQYdWPFGAFLCKVSSYVISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPT 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LsYYRQSQL---ANLTVC-----HPAWSAPRRRAMDICTFVfsylLPVLVLGLTYARTLRYLWRAVDPVAAGsgaRRAKR 175
Cdd:cd14985  136 F-LLRSLQAienLNKTACimlypHEAWHFGLSLELNILGFV----LPLLIILTCYFHIARSLRKRYERTGKN---GRKRR 207
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 176 KVTRMILIVAALFCLCWMPHHALI-------LCVWFGQFPLTRATYALRIlSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14985  208 KSLKIIFALVVAFLVCWLPFHFFKfldflaqLGAIRPCFWELFLDLGLPI-ATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
28-246 7.71e-35

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 128.56  E-value: 7.71e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSY- 106
Cdd:cd14997   61 TWAREPWLLGEFMCKLVPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFIt 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 -YRQSQLAN---LTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGS-----GARRAKRKV 177
Cdd:cd14997  141 eFKEEDFNDgtpVAVCRTPADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRAdaanrHTLRSRRQV 220
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 178 TRMILIVAALFCLCWMPHHALILCVWF---------GQFPLTRATYALRILshlvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14997  221 VYMLITVVVLFFVCLLPFRVVTLWIIFapdedlqalGLEGYLNLLVFCRVM----VYLNSALNPILYNLMSTKFRSAF 294
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
34-244 8.41e-35

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 127.95  E-value: 8.41e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15088   66 WYFGEVMCKIITALDANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFP 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 N-LTVCHPAWSAPRR-RAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRkVTRMILIVAALFCLC 191
Cdd:cd15088  146 DgTTFCYVSLPSPDDlYWFTIYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKR-VTKMVILIVVVFIVC 224
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 192 WMPHHALILCvwfgQFPLTRATYALRI---LSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15088  225 WLPFHVVQLV----NLAMNRPTLAFEVayfLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
31-246 1.94e-34

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 126.74  E-value: 1.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYyrqS 110
Cdd:cd15206   63 LRNFIFGEVMCKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVF---S 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLT-----VCHPAW-SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWravdpvaagsgarRAKRKVTRMILIV 184
Cdd:cd15206  140 NLIPMSrpgghKCREVWpNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL-------------EAKKRVIRMLFVI 206
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 185 AALFCLCWMPHHalILCVWFGQFPLTRATYALRI---LSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15206  207 VVEFFICWTPLY--VINTWKAFDPPSAARYVSSTtisLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
26-246 3.95e-34

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 126.12  E-value: 3.95e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15973   57 AASAALQHWPFGSAMCRTVLSVDGINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIII 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YY------RQSQLANLTVCHPAWSAprrrAMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVTR 179
Cdd:cd15973  137 FAdtatrkGQAVACNLIWPHPAWSA----AFVIYTFLLGFLLPVLAIGLCYILIIGKM-RAVALKAGWQQRRKSEKKITR 211
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 180 MILIVAALFCLCWMPHHALILCVWFgqfpLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15973  212 MVLMVVTVFVICWMPFYVVQLLNLF----LPRLDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
25-246 1.24e-33

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 125.02  E-value: 1.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATiYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd14984   56 WAV-YAADGWVFGSFLCKLVSALYTINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEF 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYRQSQLANLTVCHP--------AWSAPRRRAMdictFVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgARRAKRK 176
Cdd:cd14984  135 IFSQVSEENGSSICSYdypedtatTWKTLLRLLQ----NILGFLLPLLVMLFCYSRIIRTLLRA---------RNHKKHR 201
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 177 VTRMILIVAALFCLCWMPHHALILC---VWFGQFPLT-----RATYALRILSHLvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14984  202 ALRVIFAVVVVFFLCWLPYNIVLLLdtlQLLGIISRScelskSLDYALQVTESL-AFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
28-246 1.29e-33

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 124.89  E-value: 1.29e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYT--LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15094   57 IVTmiLKYWPFGAAMCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIIL 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHPAW----SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVTRMI 181
Cdd:cd15094  137 YASTVPDSGRYSCTIVWpdssAVNGQKAFTLYTFLLGFAIPLLLISVFYTLVILRL-RTVGPKNKSKEKRRSHRKVTRLV 215
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 182 LIVAALFCLCWMPHhalilcvWFGQFPL---------TRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15094  216 LTVISVYIICWLPY-------WAFQVHLiflppgtdmPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
34-246 2.27e-33

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 124.77  E-value: 2.27e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP--------YLS 105
Cdd:cd14979   67 WAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPilflmgiqYLN 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVD----------PVAAGSGARRAKR 175
Cdd:cd14979  147 GPLPGPVPDSAVCTLVVDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNikkgtraqgtRNVELSLSQQARR 226
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 176 KVTRMILIVAALFCLCWMPHHA--LILCVWFG-QFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14979  227 QVVKMLGAVVIAFFVCWLPFHAqrLMFSYASKeDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
25-244 2.79e-33

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 124.09  E-value: 2.79e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd15193   56 WAASTALGGqWLFGEGLCKLSSFIIAVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPS 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRqsqLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdPVAAGSGARRAKRKVTRMILI 183
Cdd:cd15193  136 LVYRN---LINESVCVEDSSSRFFQGISLATLFLTFVLPLIVILFCYCSILVRLRR---HFHGAKRTGRRRRNSLRIVFA 209
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 184 VAALFCLCWMPHH---ALILCVWFGQFPLTRATY-ALR---ILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15193  210 IVTAFVLSWLPFNtlkAVRLLLELGGGVLPCHTTvAIRqglTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
27-246 4.17e-33

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 123.70  E-value: 4.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSY 106
Cdd:cd14992   59 TYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYY 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSQLANLTVCHPA-----WSAPRRRAMDI---CTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGAR----RAK 174
Cdd:cd14992  139 ATTEVLFSVKNQEKIfccqiPPVDNKTYEKVyflLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSIKEVErkrlKCK 218
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 175 RKVTRMILIVAALFCLCWMPHHAL-ILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14992  219 RRVIKMLVCVVVLFVICWLPFHLFfLLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
29-246 1.45e-32

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 122.03  E-value: 1.45e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL---- 104
Cdd:cd15090   60 YLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMfmat 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 -SYYRQSQLANLTVCHPAWSAprRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVTRMILI 183
Cdd:cd15090  140 tKYRQGSIDCTLTFSHPSWYW--ENLLKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSGSKEKDRNLRRITRMVLV 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 184 VAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15090  217 VVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
26-246 2.58e-32

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 121.36  E-value: 2.58e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRElRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15002   59 AAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVT-IKQRRITAVVASIWVPACLLPLPQWL 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHPAWSAPRRR---AMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRaKRKVTRMIL 182
Cdd:cd15002  138 FRTVKQSEGVYLCILCIPPLAHEfmsAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIR-SRKLTHMLL 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 183 IVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15002  217 SVVLAFTILWLPEWVAWLWLIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
25-246 4.22e-32

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 120.93  E-value: 4.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYtLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRelRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd15392   59 IALLI-LQYWPFGEFMCPVVNYLQAVSVFVSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATALPIA 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYR----QSQLANLTVCHPAW-SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGA----RRAKR 175
Cdd:cd15392  136 ITSRlfedSNASCGQYICTESWpSDTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRTPGEAENNRdqrmAESKR 215
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 176 KVTRMILIVAALFCLCWMPHHALIL-------CVWFGQFPLtratyaLRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15392  216 KLVKMMITVVAIFALCWLPLNILNLvgdhdesIYSWPYIPY------LWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
32-246 8.47e-32

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 120.00  E-value: 8.47e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELrTPRNALAAIGLIWGLSLLFSGPYL----SYY 107
Cdd:cd14969   64 GRWSFGDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLFWALPPLfgwsSYV 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 RQSQlanLTVCHPAWSA--PRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGA------RRAKRKVTR 179
Cdd:cd14969  143 PEGG---GTSCSVDWYSkdPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSaitkrtKKAEKKVAK 219
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 180 MILIVAALFCLCWMPHhaLILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14969  220 MVLVMIVAFLIAWTPY--AVVSLYVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
34-246 1.60e-31

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 119.20  E-value: 1.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15092   65 WPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVED 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRRR---AMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVTRMILIVAALFCL 190
Cdd:cd15092  145 EEIECLVEIPTPQDYwdpVFGICVFLFSFIIPVLIISVCYSLMIRRL-RGVRLLSGSKEKDRNLRRITRLVLVVVAVFVG 223
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 191 CWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15092  224 CWTPIQIFVLAQGLGVQPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
26-246 3.57e-31

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 118.52  E-value: 3.57e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLS--LLFSGPY 103
Cdd:cd15091   57 STVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSssVGISAIV 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQSQLANLTVCHPAWSAPRRR----AMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVTR 179
Cdd:cd15091  137 LGGTKVREDVDSTECSLQFPDDDYSwwdtFMKICVFIFAFVIPVLIIIVCYTLMILRL-KSVRLLSGSREKDRNLRRITR 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 180 MILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15091  216 LVLVVVAVFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
34-246 3.58e-31

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 118.66  E-value: 3.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRelRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15393   66 WVLPRFMCPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHPLKAR--CSKKSAKIIILIIWILALLVALPVALALRVEELT 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 ----NLTV--CHPAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAgSGAR-----RAKRKVTRMI 181
Cdd:cd15393  144 dktnNGVKpfCLPVGPSDDwWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNA-QDVRddeilKNKKKVIKML 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 182 LIVAALFCLCWMP---------------HHALILCVWFgqfpltratyalriLSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15393  223 IIVVALFALCWLPlqtynllneikpeinKYKYINIIWF--------------CSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
34-243 1.47e-30

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 117.23  E-value: 1.47e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRElrTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQL- 112
Cdd:cd15391   66 WVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRSRH--TKSRTKCIIASIWAISFSLSSVQLFAGRTQRYg 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ---ANLTVCHPAWSAP--RRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGAR----RAKRKVTRMILI 183
Cdd:cd15391  144 qysEGRVLCGESWPGPdtSRSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTAPGNADKGRDdmqiKSKRKVIKMLVF 223
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 184 VAALFCLCWMPHHALILCVWFG------QFPLTRATYAlriLSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15391  224 VVLMFGICWLPLHLFNLVQDFStvfrnmPQHTTRLIYG---ACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
34-246 1.98e-30

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 116.44  E-value: 1.98e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYyrQSQLA 113
Cdd:cd15972   65 WPFGSFMCRLVMTVDAINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIF--SGVPG 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPR---RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARR-AKRKVTRMILIVAALFC 189
Cdd:cd15972  143 GMGTCHIAWPEPAqvwRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRgSERKVTRMVVIVVAAFV 222
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 190 LCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15972  223 LCWLPFYALNIVNLVCPLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
29-246 5.64e-30

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 115.43  E-value: 5.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSY-Y 107
Cdd:cd15089   60 YLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMaV 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 RQSQLANLTVCHPAWSAPR---RRAMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVTRMILIV 184
Cdd:cd15089  140 TKTPRDGAVVCMLQFPSPSwywDTVTKICVFIFAFVVPILVITVCYGLMILRL-RSVRLLSGSKEKDRNLRRITRMVLVV 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 185 AALFCLCWMPHHALILcVWF-----GQFPLTRATYALRIlshLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15089  219 VAAFIICWTPIHIFVI-VWTlvdidRRNPLVVAALHLCI---ALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
34-246 1.21e-29

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 114.17  E-value: 1.21e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15971   65 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKH 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRR---RAMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVTRMILIVAALFCL 190
Cdd:cd15971  145 GRSSCTIIWPGESSawyTGFIIYTFILGFFVPLTIICLCYLFIIIKV-KSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVF 223
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 191 CWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15971  224 CWLPFYIFNVSSVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
24-245 2.08e-29

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 113.69  E-value: 2.08e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  24 QWATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd15012   55 QNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPY 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRqsqlaNLTVCHPAWSAPRRRAMDIC-----------TFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagSGARR 172
Cdd:cd15012  135 FVFSQ-----TVEILVTQDGQEEEICVLDRemfnsklydtiNFIVWYLIPLLIMTVLYSKISIVLWK--------SSSIE 201
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 173 AKRKVTRMILIVAALFCLCWMPHHALILCVWF--GQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKG 245
Cdd:cd15012  202 ARRKVVRLLVAVVVSFALCNLPYHARKMWQYWsePYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
25-246 4.34e-29

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 112.98  E-value: 4.34e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLD-GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd14976   58 WAVEYALDfVWPFGTAMCKVVRYVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPE 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQS-QLANLTVC---HPAWSAPRRR-----AMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVdpvaaGSGARRaK 174
Cdd:cd14976  138 AIFSTDTwSSVNHTLCllrFPKNSSVTRWynwlgMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKR-----GGSKRR-K 211
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 175 RKVTRMILIVAALFCLCWMPHHALILCVWFGQF---PLTRATYALRI----LSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14976  212 SRVTKSVFIVVLSFFICWLPNQALSLWSALIKFddvPFSDAFFAFQTyafpVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-246 8.59e-29

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 112.33  E-value: 8.59e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALaaIGLIWGLSLLFSGPYLSY 106
Cdd:cd16003   59 IYALHSeWYFGEAYCRFHNFFPITSVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVV--IGSIWILAFLLAFPQCLY 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSQLANLTVCHPAW--SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGS---GARRAKRKVTRMI 181
Cdd:cd16003  137 SKTKVMPGRTLCFVAWpgGPDQHFTYHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDkyhEQLRAKRKVVKMM 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 182 LIVAALFCLCWMPHHALILCVWFGQfPLTRATYALRIL--SHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd16003  217 IIVVLTFAICWLPYHIYFIVTGLYQ-QLNRWKYIQQVYlaSFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
26-246 1.24e-28

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 111.43  E-value: 1.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15974   57 ATQNAISYWPFGSFLCRLVMTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVII 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQlaNLTVCHPAWSAPR---RRAMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVTRMIL 182
Cdd:cd15974  137 FSDVQP--DLNTCNISWPEPVsvwSTAFIIYTAVLGFFGPLLVICLCYLLIVIKV-KSSGLRVGSTKRRKSERKVTRMVV 213
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 183 IVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15974  214 IIVVVFVFCWLPFYMLNIVNLIVILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
34-244 3.33e-28

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 110.24  E-value: 3.33e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15115   65 WPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDG 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAprrrAMDICTFVFSYLLPVLVLGLTYARTLRylwravdPVAAGSGARRAKRKVTRMILIVAALFcLCWM 193
Cdd:cd15115  145 NHTRCGYDFLV----AITITRAVFGFLLPLLIIAACYSFIAF-------RMQRGRFAKSQSKTFRVIIAVVVAFF-VCWA 212
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767996348 194 PHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15115  213 PYHIIGILSLYGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
31-246 4.80e-28

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 109.90  E-value: 4.80e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYY--R 108
Cdd:cd15979   63 MGTFIFGEVICKAVAYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSvtV 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTV---CHPAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVdpvaagsgarRAKRKVTRMILIV 184
Cdd:cd15979  143 PVPVGDRPRghqCRHAWPSAQvRQAWYVLLLLILFFIPGVVMIVAYGLISRELYRGL----------LAKKRVIRMLVVI 212
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 185 AALFCLCWMPHHALILCVWFGQFPLTRATYALRI-LSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15979  213 VAMFFLCWLPIFSANTWRAFDPLSAHRALSGAPIsFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
31-246 5.12e-28

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 110.00  E-value: 5.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQS 110
Cdd:cd15970   62 LRHWPFGSLLCRLVLSVDAINMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTA 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTV-CHPAWSAPRRRAMD---ICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVTRMILIVAA 186
Cdd:cd15970  142 PNSDGSVaCNMQMPEPSQRWLAvfvVYTFLMGFLLPVIAICLCYILIIVKM-RVVALKAGWQQRKRSERKITLMVMMVVT 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 187 LFCLCWMPHHALILC-VWFGQFPLTratyaLRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15970  221 VFVICWMPFYVVQLVsVFVGQHDAT-----VSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
25-246 9.14e-28

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 109.29  E-value: 9.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WAtIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGlIWGLSLLFSGPYL 104
Cdd:cd15178   56 WA-VSVVKGWIFGTFMCKLVSLLQEANFYSGILLLACISVDRYLAIVHATRALTQKRHLVKFVCAG-VWLLSLLLSLPAL 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 sYYRQ---SQLANLTVCH----PAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgARRAKRKV 177
Cdd:cd15178  134 -LNRDafkPPNSGRTVCYenlgNESADKWRVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQT---------RSFQKHRA 203
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 178 TRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALR-------ILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15178  204 MRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLITETCELRnhvdvalYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
34-243 2.10e-27

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 108.62  E-value: 2.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSreLRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd14986   66 WVAGDVLCRIVKYLQVVGLFASTYILVSMSLDRYQAIVKPMSS--LKPRKRARLMIVVAWVLSFLFSIPQLVIFVERELG 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTV-CHPAWSAPRRRAMDIcTFVFSYLL--PVLVLGLTYARTLRYLW--------RAVDPVAAGSGAR----------- 171
Cdd:cd14986  144 DGVHqCWSSFYTPWQRKVYI-TWLATYVFviPLIILSYCYGRILRTIWirsrqktdRPIAPTAMSCRSVscvssrvslis 222
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 172 RAKRKVTRMILIVAALFCLCWMPHHAL-ILCVWFGQFPLTRATYalrILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd14986  223 RAKIKTIKMTLVIILAFILCWTPYFIVqLLDVYAGMQQLENDAY---VVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
40-244 3.76e-27

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 108.10  E-value: 3.76e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  40 LCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL-------SYYRQSQL 112
Cdd:cd14978   76 FLPYIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFfeyevveCENCNNNS 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWSAP--RRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGAR-------RAKRKVTRMILI 183
Cdd:cd14978  156 YYYVIPTLLRQNEtyLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRrllsrsqRRERRTTIMLIA 235
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 184 VAALFCLCWMPHHAL-ILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd14978  236 VVIVFLICNLPAGILnILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRR 297
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
25-244 1.18e-26

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 106.77  E-value: 1.18e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATiYTLDG--WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP 102
Cdd:cd15190   67 WAV-YTALGyhWPFGSFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALP 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLSYYRQSQL--ANLTVCH------------PAWSAprrrAMDICTFVFSYLLPVLVL-------GLTYARTLRYLWRAV 161
Cdd:cd15190  146 ALILRTTSDLegTNKVICDmdysgvvsneseWAWIA----GLGLSSTVLGFLLPFLIMltcyffiGRTVARHFSKLRRKE 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 162 DpvaagsgarRAKRKVTRMILIVAALFCLCWMPHH---ALILCVWFGQFPLTRATYALRILSH----LVSYANSCVNPIV 234
Cdd:cd15190  222 D---------KKKRRLLKIIITLVVTFALCWLPFHlvkTLYALMYLGILPFSCGFDLFLMNAHpyatCLAYVNSCLNPFL 292
                        250
                 ....*....|
gi 767996348 235 YALVSKHFRK 244
Cdd:cd15190  293 YAFFDPRFRQ 302
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-244 1.44e-25

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 103.51  E-value: 1.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRelRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15204   68 WTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVHPLKPR--MKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYA 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NL--TVCHPAWSA---PRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDP---VAAGSGARRAKRKVTRMILIVA 185
Cdd:cd15204  146 NQgkIFCGQIWPVdqqAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPgqqTEQIRRRLRRRRRKVRLLVVIL 225
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 186 ALFCLCWMPHHALILCVWFgqFPLTRATYALRILSHLVSYA----NSCVNPIVYALVSKHFRK 244
Cdd:cd15204  226 TAFVLCWAPYYGYAIVRDF--FPTLLSKEKLNTTIFYIVEAlamsNSMINTVVYVAFNNNIRK 286
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
30-246 1.45e-25

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 103.71  E-value: 1.45e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  30 TLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQ 109
Cdd:cd15205   62 ISSNWLGGAFMCKMVPFVQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQL 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 SQLANL------TVCHPAWSAP-RRRAMDICTFVFSYLLPVLVLGLTYARTLRYLW-----------RAVDPVAAGSGAR 171
Cdd:cd15205  142 EVKYDFlyekrhVCCLERWYSPtQQKIYTTFILVILFLLPLTTMLFLYSRIGYELWikkrvgdasvlQTIHGIEMSKISR 221
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 172 RAKRKVtRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRIL---SHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15205  222 KKKRAV-KMMVTVVLLFAVCWAPFHVVHMMIEYSNLENKYDGVTIKLIfaiVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
25-246 1.50e-25

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 103.28  E-value: 1.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATiYTLDG--WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP 102
Cdd:cd15192   56 WAA-YTAMEyhWPFGNFLCKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLsYYRQSQLA---NLTVC---HPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYarTLryLWRAVDPVAAGSGARRAKRK 176
Cdd:cd15192  135 AI-IHRDVFFIentNITVCafhYPSQNSTLLVGLGLMKNLLGFLIPFLIILTCY--TL--IGKALKKAYEIQRNKPRNDE 209
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 177 VTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSH------LVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15192  210 IFKMIMAVVLFFFFCWIPHQIFTFLDVLIQLKVIQDCHIADIVDTampftiCIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
34-244 2.90e-25

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 102.53  E-value: 2.90e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLsYYR---QS 110
Cdd:cd15116   65 WPFGRFMCKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSF-IFRdtaPS 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTVCHPAWSAP--------------RRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagsgARRAK-R 175
Cdd:cd15116  144 QNNNKIICFNNFSLSgdnsspevnqlrnmRHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKR----------NRLAKsS 213
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 176 KVTRMILIVAALFCLCWMPHHALILCVWFG-QFPLTRATYALRILSHLvSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15116  214 KPFKIIAAVIVTFFLCWAPYHILNLLEMEAtRSPASVFKIGLPITSSL-AFINSCLNPILYVFMGQDFKK 282
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
32-246 3.68e-25

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 102.40  E-value: 3.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQ 111
Cdd:cd15168   64 DHWIFGDFMCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGR 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWS---APRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvAAGSGARRAKRKVTRMILIVAALF 188
Cdd:cd15168  144 KNNRTTCYDTTSpeeLNDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRK----LGEGVTSALRRKSIRLVIIVLALF 219
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 189 CLCWMPHH---ALILCVWFGQFPLTRAT----YALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15168  220 AVCFLPFHvtrTINLAARLLSGTASCATlngiYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
25-246 6.33e-25

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 101.75  E-value: 6.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLD-GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRElRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd15191   56 WATYYSYGyNWLFGSVMCKICGSLLTLNLFASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPT 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LsYYRQS---QLANLTVC--------HPAWSAprrrAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPvaagSGARR 172
Cdd:cd15191  135 F-YFRDTyyiEELGVNACimafpnekYAQWSA----GLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGF----GKNKQ 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 173 AKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSY------ANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15191  206 RRDKVLKMVAAVVLAFLICWFPFHVLTFLDALARMGVINNCWVITVIDKALPFaiclgfSNSCINPFLYCFVGNHFREKL 285
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
31-246 7.84e-25

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 101.49  E-value: 7.84e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSY---- 106
Cdd:cd15978   63 LKDFIFGSAVCKTATYFMGISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYsnlv 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 -YRQSQLANLTVCHPAW-SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAagsgarrAKRKVTRMILIV 184
Cdd:cd15978  143 pFTRINNSTGNMCRLLWpNDVTQQSWYIFLLLILFLIPGIVMMTAYGLISLELYRGIKFLM-------AKKRVIRMLIVI 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 185 AALFCLCWMPhhalILCVwfGQFPLTRATYALRILS-------HLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15978  216 VILFFLCWTP----IFSA--NAWRAFDTRSADRLLSgapisfiHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
25-244 1.38e-24

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 100.61  E-value: 1.38e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WAtIYTLDG--WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP 102
Cdd:cd15381   56 WA-INISNGfnWPFGEFLCKSVNAVIYMNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLSYYRQSQLA--NLTVC-----HPAWSAprrrAMDICTFVFSYLLPVLVLGLTYARTLRYL-------WRAVdpvaags 168
Cdd:cd15381  135 MIVFRTVMYFPeyNITACvldypSEGWHV----ALNILLNVVGFLIPLSIITFCSTQIIQVLrnnkmqkFKEI------- 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 169 garRAKRKVTRMILIVAALFCLCWMPHHAL----ILCVwFGQFPLTRATYALRILSHL---VSYANSCVNPIVYALVSKH 241
Cdd:cd15381  204 ---QTERKATVLVLAVLLMFFICWLPFHIFtfldTLHK-LGLISGCRWEDILDIGTQIatfLAYSNSCLNPLLYVIVGKH 279

                 ...
gi 767996348 242 FRK 244
Cdd:cd15381  280 FRK 282
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
34-246 2.49e-24

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 99.83  E-value: 2.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15162   66 WIFGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLP 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NL--TVCHPAWS----APRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwravdPVAAGSGARRAKRKVTRMILIVAAL 187
Cdd:cd15162  146 ALdiTTCHDVLPeqllVGDWFYYFLSLAIVGFLIPFILTASCYVATIRTL-----AALEDENSEKKKKRAIKLAATVLAI 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 188 FCLCWMPHHALILCVWFGQFPL-TRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15162  221 FIICFAPSNLLLLAHYSLISSSgTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
33-244 2.72e-24

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 100.20  E-value: 2.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRtpRNALAAIGLIWGLSLLFSGPYL--SYYRQS 110
Cdd:cd15394   66 GWVFGRFMCYFVFLMQPVTVYVSVFTLTAIAVDRYYVTVYPLRRRISR--RTCAYIVAAIWLLSCGLALPAAahTYYVEF 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTVCHPAWSAPR--RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGA----RRAKRKVTRMILIV 184
Cdd:cd15394  144 KGLDFSICEEFWFGQEkqRLAYACSTLLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQSQaewdRARRRKTFRLLVVV 223
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 185 AALFCLCWMPHHAL-ILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15394  224 VVAFAICWLPLHIFnVIRDIDIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRG 284
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
34-243 4.15e-24

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 99.49  E-value: 4.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYyrqsqla 113
Cdd:cd15928   66 WRFGDLLCRLMYFFSETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVL------- 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 nLTVCHPAWSAPRR--------------RAMDICTFVFsYLLPVLVLGLTYARTLRYLWRAVDPV--AAGSGARRAKRKV 177
Cdd:cd15928  139 -VGVEHIQGQQTPRgfectvvnvssgllSVMLWVSTSF-FFVPMVCLSLLYGLIGRALWDRRQRSrtAGASRRDNNHRQT 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 178 TRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATY---ALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15928  217 VRMLAVIVLAFVLCWLPFHVGRVIFNHSRASTKHLHYvsqYFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
34-246 4.85e-24

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 99.12  E-value: 4.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15338   69 WHFGETMCTLITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLP 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTV-CHPAWSAPRRRA--MDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKrKVTRMILIVAALFCL 190
Cdd:cd15338  149 DGSVgCALLLPNPETDTywFTLYQFFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVRTK-KVTRMAVAICLAFFI 227
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 191 CWMPHHALILCvwfgQFPLTRATYALRILSHL---VSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15338  228 CWAPFYILQLA----HLSIDRPSLAFLYAYNVaisMGYANSCINPFLYIMLSETFKRQF 282
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
27-246 5.02e-24

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 99.00  E-value: 5.02e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSy 106
Cdd:cd14995   61 SLLGPDSWIYGYAGCLLITYLQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLF- 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 yrqsqLANLTVCHPAWSAPRRRAMDI----------CTFVFSYLLPVLVLGLTYARTLRYLWravdpvaagsgarRAKRK 176
Cdd:cd14995  140 -----LLDLSIKHYGDDIVVRCGYKVsrhyylpiylADFVLFYVIPLLLAIVLYGLIGRILF-------------SSRKQ 201
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 177 VTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALriLSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14995  202 VTKMLAVVVVLFALLWMPYRTLVVYNSFASPPYLDLWFLL--FCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
33-246 5.53e-24

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 99.36  E-value: 5.53e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTpRNALaAIGLIWGLSLLFSGPYLSYYRQSQL 112
Cdd:cd15383   66 QWYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARR-RNRI-MLCAAWGLSALLALPQLFLFHTVTA 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ---ANLTVCHPAWSAPRR---RAMDICTFVFSYLLPVLVLGLTYARTL----RYLWRAVDPVAAGSGAR-------RAKR 175
Cdd:cd15383  144 tppVNFTQCATHGSFPAHwqeTLYNMFTFFCLFLLPLLIMIFCYTRILleisRRMKEKKDSAKNEVALRsssdnipKARM 223
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 176 KVTRMILIVAALFCLCWMPHHALILCVWFgqFPLTRATYALRILSH---LVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15383  224 RTLKMTIVIVSSFIVCWTPYYLLGLWYWF--SPEMLEQTVPESLSHilfLFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
34-246 5.88e-24

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 99.09  E-value: 5.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSyYRQSQL- 112
Cdd:cd15120   65 WAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLA-FRETRLd 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 -ANLTVC--------------HPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTlrylwrAVDpVAAGSGARraKRKV 177
Cdd:cd15120  144 eKGKTICqnnyalstnwesaeVQASRQWIHVAMFVFRFLLGFLLPFLIITFCYVRM------ALK-MKERGLAR--SSKP 214
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 178 TRMILIVAALFCLCWMPHHalilcVWFGqFPLTRA-----TYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15120  215 FKVMFTAVVSFFVCWLPYH-----LHSG-LVLTRGrppslTDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
32-243 5.88e-24

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 99.06  E-value: 5.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQ 111
Cdd:cd16001   64 DRWPFGDFLCKLVRFLFYTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGS 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSAPRRRAM---DICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARrakRKVTRMILIVAALF 188
Cdd:cd16001  144 INNRTVCYDLTSPDNFGNYfpyGMVLTVTGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKAAR---AKSIRTILLVCGLF 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 189 CLCWMPHHA-----LILCVWFGQ--FPLTRATYALRILSHLVSYaNSCVNPIVYALVSKHFR 243
Cdd:cd16001  221 ALCFVPFHItrtiyLFVRVYLVQdcPLLQFVSLAYKIWRPLVSF-NSCINPLLYFLSGDSNR 281
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
26-246 6.08e-24

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 99.23  E-value: 6.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLhsrELRTPRNALAAI---GLIWGLSLLFSGP 102
Cdd:cd15123   58 ATRYIADTWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPL---ELQTSDAVLKTCckaGCVWIVSMLFAIP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 ------YLSYYRQSQLANLTVCHPaWSAPRRRAMDI----CTFVFsYLLPVLVLGLTYARTLRYLWRAV--DPVAAGSGA 170
Cdd:cd15123  135 eavfsdLYSFRDPEKNTTFEACAP-YPVSEKILQEIhsllCFLVF-YIIPLSIISVYYFLIARTLYKSTfnMPAEEHSHA 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 171 RR---AKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRAT---YALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15123  213 RKqieSRKRVAKTVLVLVALFAFCWLPNHILYLYRSFTYHTSVDSSafhLIATIFSRVLAFSNSCVNPFALYWLSKSFRQ 292

                 ..
gi 767996348 245 GF 246
Cdd:cd15123  293 HF 294
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
28-243 6.68e-24

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 99.00  E-value: 6.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTL--DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15160   58 DYTAnhHNWTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLA-NLTVCHPAW-SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVdpvaagSGARRAKRKVTRMILI 183
Cdd:cd15160  138 HDELFRDEpNHTLCYEKYpMEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQSP------SLEREEKRKIIGLLLS 211
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 184 VAALFCLCWMPHHALIL--CVWFGQFP----LTRATYALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15160  212 IVVIFLLCFLPYHVVLLvrSVIELVQNglcgFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
34-246 6.70e-24

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 99.04  E-value: 6.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15117   65 WPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKEN 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVC----------------HPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagSGARRAKRKV 177
Cdd:cd15117  145 GCTHCylnfdpwnetaedpvlWLETVVQRLSAQVITRFVLGFLVPLVIIGGCYGLIAARLWR--------EGWVHSSRPF 216
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 178 TRMILIVAALFcLCWMPHH--ALILCVWF-GQFP-LTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15117  217 RVLTAVVAAFF-LCWFPFHlvSLLELVVIlNQKEdLNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
34-246 8.09e-24

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 98.63  E-value: 8.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR--QSQ 111
Cdd:cd15114   65 WPFGAAACKLLPSLILLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRihQEH 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVC--HPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgARRAKRKVTRMILIVAALFC 189
Cdd:cd15114  145 FPEKTVCvvDYGGSTGVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSR---------RRQKSRRTLKVVTAVVVGFF 215
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 190 LCWMPHHALILCVWFGQFPLTRATYALRILSHLVS--YANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15114  216 LCWTPYHVVGLIIAASAPNSRLLANALKADPLTVSlaYINSCLNPIIYVVAGRGFRKSL 274
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-246 8.63e-24

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 98.78  E-value: 8.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALaaIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd16002   66 WYYGLEYCKFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVV--ICVIWVLAFLLAFPQGYYSDTEEMP 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRRRAMD----ICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPvaaGSGARR------AKRKVTRMILI 183
Cdd:cd16002  144 GRVVCYVEWPEHEERKYEtvyhVCVTVLIYFLPLLVIGCAYTVVGITLWASEIP---GDSSDRyheqvsAKRKVVKMMIV 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 184 VAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHL-VSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd16002  221 VVCTFAICWLPYHIYFLLQYFHPELYEQKFIQQVYLAIMwLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
27-246 8.94e-24

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 98.94  E-value: 8.94e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY--- 103
Cdd:cd15134   60 TIWQQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFaiq 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 --LSYYRQSQLANLTVCHPAWSAPRRRAMDI------CTFVFsYLLPVLVLGLTYAR---TLRY---LWRAVDPVAAGSG 169
Cdd:cd15134  140 trIVYLEYPPTSGEALEESAFCAMLNEIPPItpvfqlSTFLF-FIIPMIAIIVLYVLiglQLRRstlLRRGQRSVSGGRR 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 170 ARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRIL---SHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15134  219 SSQSRRTVLRMLVAVVVAFFICWAPFHAQRLLTVYAKNMTPPYLFINRILfyiSGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
34-243 1.30e-23

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 97.89  E-value: 1.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLsYYRQSQ-- 111
Cdd:cd15119   65 WPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPAL-YFRDTMel 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCH-------PAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagSGARRAKrKVTRMILIV 184
Cdd:cd15119  144 SINVTICFnnfhkhdGDLIVMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKR--------RTLLISS-KFFWTISAV 214
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 185 AALFCLCWMPHHalILCVW-FGQFPLTRATYALRI---LSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15119  215 IVAFFVCWTPYH--IFSILeLSIHHSSYLHNVLRAgipLATSLAFINSCLNPILYVLIGKKFK 275
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
25-244 1.45e-23

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 97.92  E-value: 1.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WA-TIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd15189   56 WAmNILNQFNWPFGELLCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPT 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQSQLA--NLTVC-----HPAWSAPRRRAMDICTFvfsyLLPVLVLGLTYARTLRYLWRAVDPVAAGSgarRAKRK 176
Cdd:cd15189  136 FLLRKIKAIPdlNITACvllypHEAWHFAHIVLLNIVGF----LLPLLVITFCNYNILQALRTREESTRCED---RNDSK 208
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 177 VTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRIL------SHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15189  209 ATALVLAVTLLFLVCWGPYHFFTFLDFLFDVGVLDECFWEHFIdiglqlAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
17-241 1.62e-23

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 97.88  E-value: 1.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  17 LNWRENVQWATiytldgwvfGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLhsRELRTPRNALAAIGLIWGLS 96
Cdd:cd15197   58 IIWRITVEWRA---------GDFACKVIRYLQVVVTYASTYVLVALSIDRYDAICHPM--NFSQSGRQARVLICVAWILS 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  97 LLFSGPYLSYYRQSQLANLTV-CHPAWSAPR--RRAMDICTFVFsYLLPVLVLGLTYARTLRYLWRAV------------ 161
Cdd:cd15197  127 ALFSIPMLIIFEKTGLSNGEVqCWILWPEPWywKVYMTIVAFLV-FFIPATIISICYIIIVRTIWKKSkiqvtinkaglh 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 162 DPVAAGSGAR----RAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYAL 237
Cdd:cd15197  206 DGSSRRSSSRgiipRAKIKTIKMTFVIVTVFIICWSPYFVFDLLDVFGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCL 285

                 ....
gi 767996348 238 VSKH 241
Cdd:cd15197  286 FSTH 289
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
26-246 1.76e-23

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 97.57  E-value: 1.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd15921   57 LTYYVLNShWPFGDIACRIILYVLYVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLL 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYRQSQLANLTVCH--PAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdPVAAGSGARRAKRKVTRMIL 182
Cdd:cd15921  137 FAKSKQHDEGSTRCLelAHDAVDKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLK---PSPALGRTRPSRRKACALII 213
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 183 IVAALFCLCWMPHHAL---ILCVWFGQFPLTRATYALR---ILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15921  214 ISLGIFLVCFLPYHIVrtiHLITERQIKESCGYILRVRkaaVITLCLAASNSCFDPLLYFFVGENFRSRL 283
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
29-247 2.56e-23

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 98.31  E-value: 2.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR 108
Cdd:PHA03087  99 YILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYT 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVCHPAWSAPRRRAMDICTF---VFSYLLPVLVLGLTYARTLRYLwravdpvaAGSGARRAKRKVTRMILIVA 185
Cdd:PHA03087 179 TKKDHETLICCMFYNNKTMNWKLFINFeinIIGMLIPLTILLYCYSKILITL--------KGINKSKKNKKAIKLVLIIV 250
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 186 ALFCLCWMPHHAL-------ILCVWFGQFPLTRATYALRIlSHLVSYANSCVNPIVYALVSKHFRKGFR 247
Cdd:PHA03087 251 ILFVIFWLPFNVSvfvyslhILHFKSGCKAVKYIQYALHV-TEIISLSHCCINPLIYAFVSEFFNKHKK 318
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
19-243 3.59e-23

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 96.79  E-value: 3.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  19 WRENvqwatIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLL 98
Cdd:cd15380   56 WAEN-----IRNQFNWPFGNFLCRVISGVIKANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGL 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  99 FSGPYLSYYRQSQLANLTVC-------HPAWSAPRRRAMDICTFvfsyLLPVLVLGLTYARTLRYLwRAVDPVAAGSGAR 171
Cdd:cd15380  131 LSIPTFLFRSVKHVPDLNISacillfpHEAWHFARRVELNIVGF----LLPLAAIVFFNFHIIASL-RERTEESRKRCGG 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 172 RAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALR------ILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15380  206 LKDTKATRLILTLVLMFLVCWTPYHFFAFLDFLFQVEVIQGCFWEEfidlglQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
32-245 3.85e-23

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 96.77  E-value: 3.85e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQ 111
Cdd:cd15968   64 DRWLFGDFMCRLVRFLFYFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGI 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCH---PAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRakRKVTRMILIVAALF 188
Cdd:cd15968  144 IRNRTVCYdlaPPALFPHYVPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTLGPAEPPAQARR--RKSIRTIVTVTLLF 221
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 189 CLCWMPHH---ALILCVWFGQ----FPLTRATYALRILSHLVSyANSCVNPIVYALVSKHFRKG 245
Cdd:cd15968  222 ALCFLPFHitrTIYLAVRVTPgvpcHVLEAVAACYKITRPLAS-ANSVLNPLLYFLTKKKFGRR 284
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
29-246 4.19e-23

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 96.73  E-value: 4.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAV----HFLIFltmhASSFTLAAVSLDRYLAIRYPLHSREL--RTPRNALAAIGLIWGLSLLFSGP 102
Cdd:cd15087   60 HLLQQWPFGELLCKLIlsidHYNIF----SSIYFLTVMSVDRYLVVLATVRSRRMpyRTYRAAKIVSLCVWLLVTIIVLP 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLSYYR-QSQLANLTVCHPAWSAPRR---RAMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAKRKVT 178
Cdd:cd15087  136 FTVFAGvYSNELGRKSCVLSFPSPESlwfKASRIYTLVLGFAIPVSTICILYTMMLYKL-RNMRLNSNAKALDKAKKKVT 214
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 179 RMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15087  215 LMVLVVLAVCLFCWTPFHLSTVVALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
37-244 4.20e-23

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 96.15  E-value: 4.20e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  37 GSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELrTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLAN-- 114
Cdd:cd15196   69 GDLLCRLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVGSgv 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 115 ---LTVCHPAWSaprRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWravdpvaagsgarRAKRKVTRMILIVAALFCLC 191
Cdd:cd15196  148 ydcWATFEPPWG---LRAYITWFTVAVFVVPLIILAFCYGRICYVVW-------------RAKIKTVKLTLVVVACYIVC 211
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767996348 192 WMPHH-ALILCVWFGQFPLTRAtyALRILSHLVSYaNSCVNPIVYALVSKHFRK 244
Cdd:cd15196  212 WTPFFvVQMWAAWDPTAPIEGP--AFVIIMLLASL-NSCTNPWIYLAFSGNLRR 262
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
26-246 9.24e-23

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 96.12  E-value: 9.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLhsrELRTPrNALAAI----GLIWGLSLLFSG 101
Cdd:cd15124   58 ASRYLADEWLFGRVGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPM---DIQAS-NALMKIclkaALIWILSMLLAI 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 102 PYL------SYYRQSQLANLTVCHPAWSA----PRRRAMdiCTFVFSYLLPVLVLGLTYARTLRYLWRAVD--PVAAGSG 169
Cdd:cd15124  134 PEAvfsdlhPFYDKSTNKTFVSCAPYPHSnelhPKIHSM--ASFLIFYVIPLSIISVYYYFIAKNLIRSAYnlPVEGNVH 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 170 ARR---AKRKVTRMILIVAALFCLCWMPHHALIL--CVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15124  212 VRRqieSRKRLAKTVLVFVGLFAFCWLPNHIIYLyrSYHYSEVDTSMLHFVSSICARILAFTNSCVNPFALYLLSKSFRK 291

                 ..
gi 767996348 245 GF 246
Cdd:cd15124  292 QF 293
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
28-244 2.26e-22

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 94.81  E-value: 2.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTL-DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRElrTPRNALAAIGLIWGLSLLFSGPYLSY 106
Cdd:cd15397   59 VYTLmDYWIFGEVLCKMTPFIQCMSVTVSILSLVLIALERHQLIINPTGWKP--SVSQAYLAVVVIWMLACFISLPFLAF 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 -------YRQ-----SQLANLTVCHPAW-SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGA-RR 172
Cdd:cd15397  137 hiltdepYKNlshffAPLADKAVCTESWpSEHHKLAYTTWLLLFQYCLPLLFILVCYLRIYLRLRRRKDMLERRGEYnRR 216
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 173 AK--RKVTRMILIVAALFCLCWMPHHAL-ILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15397  217 AGhsKRINVMLVSLVAAFALCWLPLNVFnAIADWNHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
34-244 2.71e-22

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 94.54  E-value: 2.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15194   66 WRSGSFLCKGSSYIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYE 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTY---ARTLRYLWRAvdpvaagSGARRAK-RKVTRMILIVAALFC 189
Cdd:cd15194  146 EKEYCNEDAGTPSKVIFSLVSLIVAFFLPLLSILTCYctiIWKLCHHYQK-------SGKHQKKlRKSIKIVFIVVAAFV 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 190 LCWMPHHAL-ILCVWFG-QFPLTRATYALRILSHLVS----YANSCVNPIVYALVSKHFRK 244
Cdd:cd15194  219 FSWMPFNLFkALAIASGlQVEVTCLPYTLAQLGMEVSaplaFANSCANPFIYYFFDRYIRR 279
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
28-243 3.43e-22

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 94.00  E-value: 3.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTLDG--WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15161   58 VYHLSGnhWPFGEVPCRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLV 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHPAW-SAPRRRAMdiCTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaAGSGARRAKRKVTRMILIV 184
Cdd:cd15161  138 SPQTVEVNNTTVCLQLYrEKASRGAL--VSLAVAFTIPFVTTVTCYLLIIRSLRT------GKREEKPLKDKAIKMIILV 209
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 185 AALFCLCWMPHHALILcVWFGQFPLTRATYAL--------RILSHLVSyANSCVNPIVYALVSKHFR 243
Cdd:cd15161  210 LTIFLICFVPYHISRY-IYILSHNGAGASCSSrrglalanRITSCLTC-LNGALDPVMYFFVAEKFR 274
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
28-246 4.97e-22

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 93.73  E-value: 4.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTL-DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRtpRNALAAIGLIWGLSLLFSGPyLSY 106
Cdd:cd15399   59 VYTLlDEWKFGAVLCHLVPYAQALAVHVSTVTLTVIALDRHRCIVYHLESKISK--KISFLIIGLTWAASALLASP-LAI 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSQLANLT------VCHPAWSAPRRR---AMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKV 177
Cdd:cd15399  136 FREYSVIEISpdfkiqACSEKWPNGTLNdgtIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQRRRKT 215
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 178 TRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYAL-RILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15399  216 TKMLVCVVVVFAVSWLPFHAFQLASDIDSKVLDLKEYKLiYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
25-244 5.26e-22

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 93.81  E-value: 5.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLD-GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd15926   57 WAVENALDfTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPN 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQSQLANLTVCHPAWSAPRRRAM------DICTFVFSYLLPVLVLGLTYARTLRYLwraVDPVAAGSGARRaKRKV 177
Cdd:cd15926  137 AIFSTTATVSNEELCLVKFPDNRGNAQfwlglyHAQKVLLGFLIPLGIISLCYLLLVRFI---TDKNITGSSTKR-RSKV 212
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 178 TRMILIVAALFCLCWMPHHAL----IL----CVWFGQFPLTRATYALRIlSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15926  213 TKSVTIVVLSFFLCWLPNQALttwgILiklnVVHFSYEYFTTQVYIFPI-TVCLAHSNSCLNPILYCLMRREFRK 286
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
34-246 5.33e-22

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 93.15  E-value: 5.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQ---S 110
Cdd:cd15052   67 WPLPLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIdttN 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTvChpawsAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwravdpvaagsgarRAKRKVTRMILIVAALFCL 190
Cdd:cd15052  147 VLNNGT-C-----VLFNPNFVIYGSIVAFFIPLLIMVVTYALTIRLL--------------SNEQKASKVLGIVFAVFVI 206
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 191 CWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15052  207 CWCPFFITNILTGLCEECNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
32-244 5.41e-22

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 93.66  E-value: 5.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQ 111
Cdd:cd15373   64 NDWPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSD 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSAP---RRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdPVAAGSGARRAKRKVTRMILIVAALF 188
Cdd:cd15373  144 KGGNITCHDTSSPElfdQFVVYSSVMLVLLFCVPFVVILVCYALMVRKLLK---PSAGTSTNSRSKKKSVKMIIIVLAVF 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 189 CLCWMPHHAL-ILCVWFGQFPLTRATYALRILSHLVS----YANSCVNPIVYALVSKHFRK 244
Cdd:cd15373  221 ILCFLPFHVTrTLYYSFRSMDLSCGTLNAINLAYKVTrplaSANSCLDPILYFLAGQSFRS 281
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-246 6.22e-22

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 93.37  E-value: 6.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSReLRTPrNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd16004   66 WYFGLEFCRFQNFFPITAMFVSIYSMTAIAADRYMAIIHPFKPR-LSAG-STKVVIAGIWLVALALAFPQCFYSTVTMDQ 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAW----SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGAR----RAKRKVTRMILIVA 185
Cdd:cd16004  144 GRTKCIVAWpgdsGGKHQLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHGAYhrqlQAKKKFVKTMVVVV 223
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 186 ALFCLCWMPHHALILCVWFgQFPLTRATYALRILSHLVSYANSCV--NPIVYALVSKHFRKGF 246
Cdd:cd16004  224 VTFAICWLPYHLYFILGSF-NEDIYCQKYIQQVYLAIFWLAMSSTmyNPIIYCCLNQRFRSGF 285
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
34-246 6.37e-22

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 93.39  E-value: 6.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL-SYYRQSQL 112
Cdd:cd15055   66 WYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLyDNLNQPGL 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHpawsaprrramDICTFVFSYLLPVLVLGLTY---------------------ARTLRYLWRAVDP-VAAGSGA 170
Cdd:cd15055  146 IRYNSCY-----------GECVVVVNFIWGVVDLVLTFilpctvmivlymrifvvarsqARAIRSHTAQVSLeGSSKKVS 214
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 171 RRAKRKVTRMILIVAALFCLCWMPHHALILcvwFGQFPLTRATYAlRILSHLVsYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15055  215 KKSERKAAKTLGIVVGVFLLCWLPYYIVSL---VDPYISTPSSVF-DVLIWLG-YFNSCLNPLIYALFYPWFRKAL 285
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
33-246 7.14e-22

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 93.74  E-value: 7.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLhsRELRTPRNALAAIGLIWGLSLLFSGP---YLSYYRQ 109
Cdd:cd15981   65 GWPFDNAMCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPF--RQKLTLRKAIVTIVIIWVLALIIMCPsavTLTVTRE 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 ---------SQLANLTVCHPAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPV-------AAGSGARR 172
Cdd:cd15981  143 ehhfmvddyNNSYPLYSCWEAWPDTEmRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIrgsqgeeEEGRRVSK 222
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 173 AKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFP---LTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15981  223 RKIKVINMLIIVALFFTLSWLPLWTLMLLTDYGHLSedqLNLVTVYVFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
46-246 9.25e-22

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 93.09  E-value: 9.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  46 FLIFLTmHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYLSYYRQSQLANLTVCHPAW-- 122
Cdd:cd14968   77 LVLVLT-QSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGlTPMFGWNNGAPLESGCGEGGIQcl 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 123 --SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKR------KVTRMILIVAALFCLCWMP 194
Cdd:cd14968  156 feEVIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRSRRSRStlqkevKAAKSLAIILFLFALCWLP 235
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767996348 195 HHAL--ILCVWFGQFPLTRATYALRILSHlvsyANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14968  236 LHIIncITLFCPECKVPKILTYIAILLSH----ANSAVNPIVYAYRIRKFRQTF 285
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
27-244 1.18e-21

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 92.55  E-value: 1.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSY 106
Cdd:cd15187   57 AYYLLDQWVFGNAMCKIVSGAYYIGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVF 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSQLANLTVCHPAWSAPRRRAMDICTF---VFSYLLPVLVLGLTYARTLRYLWRAVDpvaagsgarRAKRKVTRMILI 183
Cdd:cd15187  137 YQVASEDGRLQCIPFYPGQGNSWKVFTNFevnILGLLIPFSILIFCYHNILRNLRRCHN---------QNKTKAIKLVFI 207
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 184 VAALFCLCWMPHHALILCVWFGQFPL-------TRATYALRiLSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15187  208 VVIVFFLFWTPFNVVLFLDSLHSLHIidgcqnsQRLTLALH-LTETISFTHCCLNPVIYAFVGEKFKK 274
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
34-243 1.53e-21

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 92.12  E-value: 1.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPyLSYYRQS--- 110
Cdd:cd15372   65 WPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLP-LTLQRQSypl 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTVCHPAwsAPRRRAMD------ICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagSGARRAkrKVTRMILIV 184
Cdd:cd15372  144 ERLNITLCHDV--LPLDEQDTylfyyfACLAVLGFLLPLVVILFCYGSVLHTLLR--------SGQRYG--HAMKLTVLV 211
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 185 AALFCLCWMPHHALILCVWFGQFPLTRAT-YALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15372  212 LVSFVLCFTPSNLLLLLHYSDPTLDDGGNlYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
33-246 1.80e-21

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 92.64  E-value: 1.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRelRTPRNALAAIGLIWGLSLLFSGPYL-------- 104
Cdd:cd15980   65 GWPFGSTVCKMSGMVQGISVSASVFTLVAIAVDRFRCIVYPFKQK--LTISTAVVIIVIIWVLAIAIMCPSAvmlhvqee 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYR-----QSQLANLTVCHPAWSAPRRRAMdICTFVFS--YLLPVLVLGLTYARTLRYLWRAVDPVAAGSG------AR 171
Cdd:cd15980  143 KNYRvvlgsQNKTSPVYWCREDWPNQEMRKI-YTTVLFAniYLAPLSLIVIMYARIGITLFKTAMPHTGKHNqeqrhvVS 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 172 RAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQfpLTRATYA-----LRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15980  222 RKKQKVIKMLLIVALLFILSWLPLWTLMMLSDYAN--LSPNQLQiiniyIYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
25-246 2.10e-21

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 92.12  E-value: 2.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd15181   55 FSVVESIAGWVFGTFLCKLVGAIHKLNFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNL 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYR--QSQLANLTVC-HPAWSAPRRRAMDICTF---VFSYLLPVLVLGLTYARTLRYLWRavdpvaagSGARRAKRKVT 178
Cdd:cd15181  135 VFLEveTSTNANRTSCsFHQYGIHESNWWLTSRFlyhVVGFFLPLLIMGYCYATIVVTLCQ--------SSRRLQKQKAI 206
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 179 RMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALR-------ILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15181  207 RVAILVTLVFCLCWLPYNIVIFLDTLDDLKAVVKNCKLNdlldaaiTVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-243 2.33e-21

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 92.17  E-value: 2.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15132   66 WIFGEFLCRLYHYISEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQDN 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTV------CHPAWSAPRRRAMDICTFVFS--YLLPVLVLGLTYARTLRYLWRAVDPV--AAGSGARRAKRKVTRMILI 183
Cdd:cd15132  146 NIHPddfsreCKHTPYAVSSGLLGIMIWVTTtyFFLPMLCLSFLYGFIGRKLWKSKNDLrgPNAAARERSHRQTVRILAV 225
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 184 VAALFCLCWMPHHalILCVWFGQFPLTRATY---ALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15132  226 VVLAFIICWLPFH--IGRILFANTEDYRTMMfsqYFNIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
29-246 8.84e-21

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 90.53  E-value: 8.84e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDgWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPL--HSRELRTPRNALAAigliWGLSLLFSGPYLSY 106
Cdd:cd15195   62 YTVE-WLAGDLMCRVMMFLKQFGMYLSSFMLVVIALDRVFAILSPLsaNQARKRVKIMLTVA----WVLSALCSIPQSFI 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 Y----RQSQLANLTVCHPAWSAPR---RRAMDICTFVFSYLLPVLVLGLTY----------ARTLRYLWRAVDPVAAGSG 169
Cdd:cd15195  137 FsvlrKMPEQPGFHQCVDFGSAPTkkqERLYYFFTMILSFVIPLIITVTCYllilfeiskmAKRARDTPISNRRRSRTNS 216
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 170 ARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15195  217 LERARMRTLRMTALIVLTFIVCWGPYYVLGLWYWFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
26-246 1.15e-20

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 89.72  E-value: 1.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd15067   57 ILHEMTGGyWLFGRDWCDVWHSFDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAI 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYRQSQlanltvchPAWSAPrrramDICTF-----------VFSYLLPVLVLGLTYARTLRylwravdpvaagsgARRA 173
Cdd:cd15067  137 AWWRAVD--------PGPSPP-----NQCLFtddsgylifssCVSFYIPLVVMLFTYYRIYR--------------AAAK 189
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 174 KRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15067  190 EQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNCVSNPDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
34-243 1.20e-20

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 89.94  E-value: 1.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY-----LSYYR 108
Cdd:cd15131   66 WNFGDLLCKLFQFVSESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIfvlvgVEHEN 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVCHPAWSAPRRRAMDICTFVFS--YLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAK--RKVTRMILIV 184
Cdd:cd15131  146 GTNPIDTNECKATEYAVRSGLLTIMVWVSSvfFFLPVFCLTVLYSLIGRKLWRRRRENIGPNASHRDKnnRQTVKMLAVV 225
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 185 AALFCLCWMPHHA--LILCVWF--GQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15131  226 VFAFVLCWLPFHVgrYLFSKSFeaGSLEIALISQYCNLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
34-246 2.03e-20

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 88.94  E-value: 2.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKavhflIFLTMH-----ASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR 108
Cdd:cd15053   67 WYLGPILCD-----IYIAMDvmcstASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLN 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVCHPAwsaprRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwravdpvaagsgarRAKRKVTRMILIVAALF 188
Cdd:cd15053  142 NVPYRDPEECRFY-----NPDFIIYSSISSFYIPCIVMLLLYYRIFRAL--------------RREKKATKTLAIVLGVF 202
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 189 CLCWMP----HHALILCVWFgQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15053  203 LFCWLPfftlNILNAICPKL-QNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
34-244 2.11e-20

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 89.05  E-value: 2.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15369   66 WLFGEAMCRVVTAAFYCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIP 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NL--TVCHPAWSAPRRRAMDICTF-VFS---YLLPVLVLGLTYARTLRYLWRAVDPvaagsGARRAKRKVTRMILIVAAL 187
Cdd:cd15369  146 DLgiTTCHDVLNEQLLMGYYVYYFsIFSclfFFVPLIITTVCYVSIIRCLSSSSDV-----ANSSKKTRALFMAVAVFCV 220
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 188 FCLCWMPHHALIL--CVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15369  221 FVICFGPTNVLLLahYVRFAYTSTNDASYFAYLLCVCVGSISCCLDPLIYYYGSSQCQK 279
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
34-246 2.13e-20

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 88.57  E-value: 2.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKA-VHFLIFLTMhASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQL 112
Cdd:cd15061   65 WPLGSHLCDFwISLDVLLCT-ASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGR 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWSAPRRramdICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagsgarraKRKVTRMILIVAALFCLCW 192
Cdd:cd15061  144 RGLGSCYYTYDKGYR----IYSSMGSFFLPLLLMLFVYLRIFRVIAK--------------ERKTAKTLAIVVGCFIVCW 205
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767996348 193 MPHHALILCVWFGQFPLTRATYalRILSHLvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15061  206 LPFFIMYLIEPFCDCQFSEALS--TAFTWL-GYFNSVINPFIYAFYNKDFRRAF 256
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
25-235 2.24e-20

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 89.42  E-value: 2.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WAtiYTLDgWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSreLRTPRNALAAIGLIWGLSLLFS---- 100
Cdd:cd15384   60 WA--YTVA-WLAGNTMCKLVKYLQVFGLYLSTYITVLISLDRCVAILYPMKR--NQAPERVRRMVTVAWILSPIFSipqa 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 101 -------GPYLSYYRQsqlanlTVCHPAWSAPRRRAMDIC-TFVFSYLLPVLVLGLTYARTLRYL---WRAVDPVAAGSG 169
Cdd:cd15384  135 vifhverGPFVEDFHQ------CVTYGFYTAEWQEQLYNMlSLVFMFPIPLVIMVTCYVLIFITLsksSRDFQGLEIYTR 208
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 170 AR---------RAKRKVTRMILIVAALFCLCWMPHHalILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVY 235
Cdd:cd15384  209 NRgpnrqrlfhKAKVKSLRMSAVIVTAFILCWTPYY--VIMIWFLFFNPYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
34-244 4.22e-20

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 88.33  E-value: 4.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR-QSQL 112
Cdd:cd15339   65 WVFGSPLCTIITSLDTCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKvIKFR 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWSAPRRRA-----MDICTFVFsyllPVLVLGLTYARTLRYLWRAVDPVAAG-----SGARRAKRKVTRMIL 182
Cdd:cd15339  145 DGLESCAFNLTSPDDVLwytlyQTITTFFF----PLPLILICYILILCYTWEMYRKNKKAgryntSIPRQRVMRLTKMVL 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 183 IVAALFCLCWMPHHALILCVWFGQFPlTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15339  221 VLVGVFLVSAAPYHVIQLVNLSVSQP-TLAFYVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
26-246 5.06e-20

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 88.47  E-value: 5.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPL----HSRELRTPRNALAaiglIWGLSLLFSG 101
Cdd:cd15125   58 ASRYFYEEWMFGTVGCKLIPVIQLTSVGVSVFTLTALSADRYKAIVNPMdiqtSSAVLRTCLKAIA----IWVVSVLLAV 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 102 PYLSYYRQSQL-----ANLTVC--HPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVaAGSGARRAK 174
Cdd:cd15125  134 PEAVFSEVAHImpddnTTFTACipYPQTDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNI-PGEYSEHSK 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 175 R------KVTRMILIVAALFCLCWMPHHALILCVWFG--QFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15125  213 RqmetrkRLAKIVLVFVGLFAFCWFPNHVLYMYRSFNynEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
33-236 6.23e-20

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 87.95  E-value: 6.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLsYYRQ--S 110
Cdd:cd15121   64 GWEFGSVVCKLCHYVCGVSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMP-FYRTvlK 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTVCHPAWSAPRRRAMD-ICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgARRAKRKVTRMILIVAALFC 189
Cdd:cd15121  143 KNINMKLCIPYHPSVGHEAFQyLFETITGFLLPFTAIVTCYSTIGRRLRSA---------RFRRKRRTNRLVVLIIATFA 213
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 190 LCWMPHHALILCVWFGQFP--------LTRATYALRILSHLVsYANSCVNPIVYA 236
Cdd:cd15121  214 LFWLPYHVVNLIQVAGALQnqagnasvLKAAKLARPNVTALA-FLSSSVNPVLYA 267
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
26-246 6.88e-20

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 87.26  E-value: 6.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15325   58 AIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLF 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHpawsAPRRRAMDICTFVFSYLLPVLVLGLTYARTLrylwravdpVAAGSGARraKRKVTRMILIVA 185
Cdd:cd15325  138 GWKEPAPEDETICQ----ITEEPGYALFSALGSFYLPLAIILVMYCRVY---------VVALKFSR--EKKAAKTLGIVV 202
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 186 ALFCLCWMPhhaLILCVWFGQ-FPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15325  203 GCFVLCWLP---FFLVMPIGSiFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
25-244 8.75e-20

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 87.62  E-value: 8.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd15183   56 WIDYKLKDDWIFGDAMCKFLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCL 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYRQSQLANLTVCHPAWsaPRRRAMDICTF------VFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgARRAKRKVT 178
Cdd:cd15183  136 YFFKSQWEFTHHTCSAHF--PRKSLIRWKRFqalklnLLGLILPLLVMIICYTGIINILLRR---------PNEKKAKAV 204
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 179 RMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRIL------SHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15183  205 RLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPSCEQSQQLdlalqvTEVIAYTHCCVNPVIYVFVGERFRK 276
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
33-246 8.99e-20

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 87.44  E-value: 8.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR--QS 110
Cdd:cd15180   63 GWIFGTGLCKLAGAVFKINFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEatKD 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTVC---HPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagSGARRAKRKVTRMILIVAAL 187
Cdd:cd15180  143 PRQNKTECvhnFPQSDTYWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLR--------SSQGFQKQRAIRVIVAVVVV 214
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 188 FCLCWMPHH-ALILCVWFGQFPL-------TRATYALRILSHLvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15180  215 FFLCWTPYNiALLVDTLIDLSVLdrncgteSRLDIALSVTSSL-GYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
25-243 1.61e-19

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 86.65  E-value: 1.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WAtIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd15182   56 WA-SYHSSGWIFGEILCKAVTSIFYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPEL 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYY--RQSQLANLTVCHPAWSaprRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgARRAKRKVTRMIL 182
Cdd:cd15182  135 ILStvMKSDEDGSLCEYSSIK---WKLGYYYQQNLFFLIPLGIIVYCYVRILQTLMRT---------RTMRKHRTVKLIF 202
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 183 IVAALFCLCWMPHHALILCVWFgqFPLTRAT--------YALRIlSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15182  203 VIVLVFFLSWAPYNIVIFLRSL--KDLTIPIcecskqldYAFYI-CRNIAFSHCCLNPVFYVFVGVKFR 268
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
27-246 2.11e-19

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 86.22  E-value: 2.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPyls 105
Cdd:cd15049   58 TVYLVMGyWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAP--- 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 yyrqsqlanLTVCHPAWSAPRRRAMDIC-------------TFVFSYLLPVLVLGLTYARtlryLWRAVdpvaagsgarR 172
Cdd:cd15049  135 ---------AILGWQYFVGERTVPDGQCyiqflddpaitfgTAIAAFYLPVLVMTILYWR----IYRET----------A 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 173 AKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYAlriLSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15049  192 RERKAARTLSAILLAFIITWTPYNILVLVSTFCAKCIPDTLWS---FGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
34-244 2.70e-19

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 86.17  E-value: 2.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRnALAAIGLIWGLSLLFSGPYL---SYYRQS 110
Cdd:cd15074   66 WLFGDIGCVFYGFCGFLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRH-VCIVIVAIWLYALFWAVAPLvgwGSYGPE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLAnlTVCHPAWSAPRRRAMD----ICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGARRAK-----RKVTRMI 181
Cdd:cd15074  145 PFG--TSCSIDWTGASASVGGmsyiISIFIFCYLLPVLIIVFSYVKIIRKV-KSSRKRVAGFDSRSKRqhkieRKVTKVA 221
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 182 LIVAALFCLCWMPHhaLILCVW--FGQFPLTRAtyALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15074  222 VLICAGFLIAWTPY--AVVSMWsaFGSPDSVPI--LASILPALFAKSSCMYNPIIYLLFSSKFRQ 282
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
34-246 2.71e-19

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 85.39  E-value: 2.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15210   66 WIHGETLCRVFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFGL 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRR-RAMDICTFVFSYLLPVLVLGLTYartlrylwravdpvaagsgARRAKRKVTRMILIVAALFCLCW 192
Cdd:cd15210  146 DPKVCSCSILRDKKgRSPKTFLFVFGFVLPCLVIIICY-------------------ARREDRRLTRMMLVIFLCFLVCY 206
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767996348 193 MPHhaLILCVWFGQfpltRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15210  207 LPI--TLVNVFDDE----VAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
34-244 4.90e-19

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 85.45  E-value: 4.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYLSYYRQSQL 112
Cdd:cd15337   67 WIWGKVACELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSiPPFFGWGRYVPE 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAW--SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWR------------AVDPVAAGSGARRAKRKVT 178
Cdd:cd15337  147 GFQTSCTFDYlsRDLNNRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNhekemtqtaksgMGKDTEKNDARKKAEIRIA 226
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 179 RMILIVAALFCLCWMPHHALILcvwFGQF-PLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15337  227 KVAIILISLFLLSWTPYAVVAL---LGQFgPAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRA 290
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
27-246 6.39e-19

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 85.43  E-value: 6.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL- 104
Cdd:cd15048   58 IPYTLTGkWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIi 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 --SYYRQSQLANLTVCHPAWsaPRRRAMDICTFVFSYLLPVLVLGLTYA--------RTLRYLWRAVDPVAAGSGARRAK 174
Cdd:cd15048  138 gwDLWTGYSIVPTGDCEVEF--FDHFYFTFITSVLEFFIPFISVSFFNLliylnirkRSRRRPLRSVPILPASQNPSRAR 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 175 RKVTRMIL-----------IVAALFCLCWMPHHALIL--------CVwfgqfpltrATYALRILSHLVsYANSCVNPIVY 235
Cdd:cd15048  216 SQREQVKLrrdrkaakslaILVLVFLICWAPYTILTIirsfcsgsCV---------DSYLYEFTFWLL-WTNSAINPFLY 285
                        250
                 ....*....|.
gi 767996348 236 ALVSKHFRKGF 246
Cdd:cd15048  286 AACHPRFRKAF 296
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-246 7.39e-19

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 85.27  E-value: 7.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS-----YYR 108
Cdd:cd15133   67 FLLGSGGCYFKTFLFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSlhgikFLG 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVCHPAWSAPRRRAMDICTFVFsYLLPVLVLGLTYarTLRYLWRAVDPVAAGSGA--------------RRAK 174
Cdd:cd15133  147 SGVPASAQCTVRKPQAIYNMIPQHTGHLF-FVLPMAVISVLY--LLMALRLARERGLDATGAgskigtrtgqllqhPRTR 223
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 175 RKVTRMILIVAALFCLCWMPHHALILcVWFGQFPLTRATYALRILSHLVS----YANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15133  224 AQVTKMLFILVVVFAICWAPFHIDRL-MWSFISDWTDNLHEVFQYVHIISgvffYLSSAVNPILYNLMSTRFREMF 298
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
26-246 7.57e-19

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 84.58  E-value: 7.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYL 104
Cdd:cd15327   58 ATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISiGPLL 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SyYRQSQLANLTVChpawSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLrylwravdpVAAGSGARraKRKVTRMILIV 184
Cdd:cd15327  138 G-WKEPPPPDESIC----SITEEPGYALFSSLFSFYLPLMVILVMYFRVY---------VVALKFSR--EKKAAKTLAIV 201
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 185 AALFCLCWMPhhaLILCVWFGQ-FPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15327  202 VGVFILCWFP---FFFVLPLGSfFPALKPSEMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
34-244 8.45e-19

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 84.69  E-value: 8.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSqlA 113
Cdd:cd15165   64 WPLGRTLCSFLESLYFVNMYGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHDKP--T 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVC-----HPAWSAPrrraMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPvaagsgaRRAKRKVTRMILIVAA-- 186
Cdd:cd15165  142 NNTRCfhgfsNKTWSKK----VIVVVEEFGFLIPMAVMVFCSVQIIRTLLDMRRP-------EQPKVKQNKSVKIVLSnl 210
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 187 -LFCLCWMPHHALILcVWF----GQFPLTRATYALRILSHL---VSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15165  211 vVFLVCFTPYHLGIF-LQFlvknDIINDCSTKQSIRLFVQVsmcLANVNCCLDAICYYFILKEFRE 275
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
26-246 1.01e-18

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 83.92  E-value: 1.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTL-DGWVFGSLLCKavhflIFLTMH-----ASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLF 99
Cdd:cd15064   57 SAVYELtGRWILGQVLCD-----IWISLDvtcctASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICI 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 100 SGPYLSYYRQSQLANLTVChpawsaprRRAMDICTFVFS----YLLPVLVLGLTYARTLRylwravdpvaagsgARRAKR 175
Cdd:cd15064  132 SLPPLFGWRTPDSEDPSEC--------LISQDIGYTIFStfgaFYIPLLLMLILYWKIYR--------------AAARER 189
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 176 KVTRMILIVAALFCLCWMPH--HALILcvwfgqfPLTRATYALRILSHLVS---YANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15064  190 KAAKTLGIILGAFIVCWLPFflVALIV-------PLCSHCWIPLALKSFFLwlgYFNSLINPLIYTFFNKDFRKAF 258
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
34-246 1.09e-18

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 84.43  E-value: 1.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY----LSYYRQ 109
Cdd:cd15368   66 WIFGKPLCNVVTVLFYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLertdLTYYVK 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 SQlaNLTVCH-----------PAWSaprrrAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvAAGSGARRAKRKVT 178
Cdd:cd15368  146 EL--NITTCFdvlkwtmlpniAAWA-----AFLFTLFILLFLIPFIITVYCYVLIILKLVQ-----TSERYGREQKRRAI 213
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 179 RMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15368  214 YLALIVLLVFITCFAPNNFILLAHMVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
27-246 1.18e-18

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 83.86  E-value: 1.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP--- 102
Cdd:cd17790   58 TTYILMGhWALGTVACDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPail 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLSYYRQSQLANLTVCHPAW-SAPrrramdICTF---VFSYLLPVLVLGLTYARTLRYLWRavdpvaagsgarraKRKVT 178
Cdd:cd17790  138 FWQYLVGERTVLAGQCYIQFlSQP------IITFgtaIAAFYLPVTIMIILYWRIYRETIK--------------EKKAA 197
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 179 RMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYAlriLSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd17790  198 RTLSAILLAFILTWTPYNIMVLVSTFCKDCVPKTLWE---LGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
34-246 1.26e-18

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 84.53  E-value: 1.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP-------YLSY 106
Cdd:cd15357   67 FLFGPVGCYFKTALFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPntsihgiKLQY 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSQL----ANLTVCHPAWSapRRRAMDICTFVFsYLLPVLVLGLTYartlrYLW-------RAVDPVAAGSGARRAKR 175
Cdd:cd15357  147 FPNGTLipdsATCTVVKPLWI--YNLIIQITSLLF-YVLPMGVISVLY-----YLMglklrgdKSLEADEMNVNIQRPSR 218
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 176 K-VTRMILIVAALFCLCWMPHHALILCVWFGQF---PLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15357  219 KsVTKMLFVLVLVFAICWAPFHVDRLFFSFVVEwtePLANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
27-246 1.44e-18

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 84.08  E-value: 1.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSY 106
Cdd:cd15122   60 TFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVY 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YR--QSQLANLTVCHPAWSAPRRRAMDIcTF--VFSYLLPVLVLGLTYARTLRYLwravdpvAAGSGARRAkrKVTRMIL 182
Cdd:cd15122  140 RHvwKDEGMNDRICEPCHASRGHAIFHY-TFetLVAFVLPFGVILFSYSVILVRL-------KGARFRRRA--RVEKLIA 209
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 183 IVAALFCLCWMPHHALILCVWFGQFP-------LTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15122  210 AIVVAFALLWVPYHVVNLLQVVANLApgevlekLGGAAKAARAGATALAFFSSSVNPLLYVFAAGDLIKTS 280
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
34-245 1.61e-18

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 83.92  E-value: 1.61e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYLSYYRQSQL 112
Cdd:cd15083   66 WIFGKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVlPPLFGWSRYVLE 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWSA--PRRRAMDICTFVFSYLLPVLVLGLTYArtlrYLWRAV------------DPVAAGSGARRAKR--- 175
Cdd:cd15083  146 GLLTSCSFDYLSrdDANRSYVICLLIFGFVLPLLIIIYCYS----FIFRAVrrhekamkemakRFSKSELSSPKARRqae 221
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 176 -KVTRMILIVAALFCLCWMPHHALILCVWFGqFPLTRATYALRILShLVSYANSCVNPIVYALVSKHFRKG 245
Cdd:cd15083  222 vKTAKIALLLVLLFCLAWTPYAVVALIGQFG-YLEVLTPLATAIPA-AFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
26-246 2.48e-18

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 83.02  E-value: 2.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYL 104
Cdd:cd15326   58 ATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISiGPLL 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SyYRQSQLANLTVChPAWSAPrrrAMDICTFVFSYLLPVLVLGLTYARTLrylwravdpVAAGSGARraKRKVTRMILIV 184
Cdd:cd15326  138 G-WKEPAPPDDKVC-EITEEP---FYALFSSLGSFYIPLIVILVMYCRVY---------IVALKFSR--EKKAAKTLGIV 201
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 185 AALFCLCWMPhhalilcvWFGQFPLTRATYALR---ILSHLV---SYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15326  202 VGMFILCWLP--------FFIALPLGSLFSHLKppeTLFKIIfwlGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-246 2.78e-18

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 83.46  E-value: 2.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL-SYYRQSQL 112
Cdd:cd15130   71 WAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLfTMGLQNES 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLT-----VCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVdpvaagsgarRAKRKVTRMILIvaaL 187
Cdd:cd15130  151 DDGThpgglVCTPIVDTATLKVVIQVNTFMSFLFPMLVTSILNTVIANKLVQAL----------RRGVLVLRAVVI---A 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 188 FCLCWMPHHA--LILC-----VWfgQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15130  218 FVVCWLPYHVrrLMFCyisdeQW--TTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
26-243 2.81e-18

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 83.22  E-value: 2.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd15157   57 ADYYLMGShWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLL 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SyYRQSQLANLTVC---HPAwSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPvaaGSGARRAKRKVTRMI 181
Cdd:cd15157  137 S-KGTSKYNSQTKCldlHPS-KIDKLLILNYIVLVVGFILPFCTLSICYILIIKALLKPRVP---QSKLRVSHKKALLTI 211
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 182 LIVAALFCLCWMPHHALiLCVWFGQFPLTRATYALR---ILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15157  212 IITLILFLLCFLPYHIL-RTVHLMQWSEGQCNLRLHkavVITLCLAAANSCLDPLLYYFAGENFK 275
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
34-246 3.11e-18

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 83.05  E-value: 3.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWgLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15155   65 WPFGDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVW-ILVLSGGISASLFSTTNVS 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NL-TVCHPAWSAPRRRA----MDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGarraKRKVTRMILIVAALF 188
Cdd:cd15155  144 NTsTTCFEGFSKSIWKTylskITIFIEVVGFIIPLLLNLTCSSLVLRTLRKPATLSQIGTN----KEKVLKMILVHVAIF 219
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 189 CLCWMPH------HALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15155  220 VVCFVPYnsilflYALVRSQAIANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
29-243 3.29e-18

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 83.23  E-value: 3.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR 108
Cdd:cd15378   60 YSNGQWLFGDFLCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIG 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVCHPAWS---APRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAkrkvTRMILIVA 185
Cdd:cd15378  140 PNLKDNVTKCKDYASsgdATNSLIYSLFLTVTGFLIPLCVMCFFYYKIALFLKNRNRQLANATSFEKP----LTLVILAV 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 186 ALFCLCWMPHHAL----ILC--VWFGQFPLTRATY-ALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15378  216 VIFSVLFTPYHVMrnvrIASrlDSIGVSECTLIIIkSLYIVTRPIAFLNSVINPVFYFLMGDHFR 280
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
34-244 6.81e-18

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 82.11  E-value: 6.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd14991   66 WIFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNS 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHP--AWSAP--RRRAMDIcTFVFSYLLPVLVLGLTYARTLRYLWRAVDPvaagSGARRAKRkVTRMILIVAALFC 189
Cdd:cd14991  146 NKSSCHSfsSYTKPslSIRWHNA-LFLLEFFLPLGLIVFCSVRIACNLRIRQSL----GKQARVQR-AIRLVFLVVIVFV 219
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 190 LCWMPHHAL-ILCVWFGQFPLTRATYALRILSHL---VSYANSCVNPIVYALVSKHFRK 244
Cdd:cd14991  220 LCFLPSIIAgLLALVFKNLGSCRCLNSVAQLFHIslaFTYLNSALDPVIYCFSSPWFRN 278
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
27-246 6.90e-18

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 82.47  E-value: 6.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTL--DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS---- 100
Cdd:cd14977   57 NAYNLltKDWLFGDVMCKLVPFIQVTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAvpea 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 101 -GPYLSYYRQSQLANLTVCHPAWSAPR----RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKR 175
Cdd:cd14977  137 vLSTVARESSLDNSSLTVCIMKPSTPFaetyPKARSWWLFGCYFCLPLAFTAVCYLLMARTLIRAAKEYTRGTKKHMKQR 216
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 176 K-VTRMILIVAALFCLCWMPHHA---LILCVWFGQFPLTRATyaLRILSHL---VSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14977  217 RqLAKTVLCLVLVFAFCWLPEHIsniLRATLYNEVLIDTRST--LDILDLIgqfLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
32-243 1.01e-17

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 81.73  E-value: 1.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPylsYYRQSQ 111
Cdd:cd15923   62 RESAGLQKLCNFVLSLYYINMYVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIP---YFLLDS 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVaagsGARRAKRKVTRMILIVAALFCLC 191
Cdd:cd15923  139 SNEKTMCFQRTKQTESLKVFLLLEIFGFLLPLIIMTFCSARVIHTLQKRLDDV----GSRSETKQCIRVIMANLIVFIVC 214
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 192 WMPHHALILCVWFGQFPLT-RATYALRILSHL---VSYANSCVNPIVYALVSKHFR 243
Cdd:cd15923  215 FLPVHVGFFVKFIVGKSYScDSKLIIHFFLQSafcLSDMNCCLDAFCYYFATKEFR 270
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
34-240 1.19e-17

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 81.37  E-value: 1.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd14975   65 WDFGLAACKGCVYVCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETV 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRRRAM-DICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgARRAKRKVTRMILIVAALFCLCW 192
Cdd:cd14975  145 ENGMCKYRHYSDGQLVFhLLLETVVGFAVPFTAVVLCYSCLLRRLRRR---------RFRRRRRTGRLIASVVVAFAACW 215
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 193 MPHH---------ALILCVWfGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSK 240
Cdd:cd14975  216 LPYHvgnllevvsELIGGSK-MAGTLGKVAEAGRPIAGALAFLSSSINPLLYAFAAR 271
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
25-246 1.76e-17

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 81.32  E-value: 1.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDG-WVFGSLLCKAVHFLIFLTMhASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS--G 101
Cdd:cd15057   57 WAAVNEVAGyWPFGSFCDVWVSFDIMCST-ASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISfiP 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 102 PYLSYYRqsqlANLTVCHPAWSAPRR-------RAMDICTFVFSYLLPVLVLGLTYARTLRY----------LWRAVD-- 162
Cdd:cd15057  136 VQLGWHR----ADDTSEALALYADPCqcdsslnRTYAISSSLISFYIPVAIMIVTYTRIYRIarrqirriaaLERAAQes 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 163 --PVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWF-----GQFPLTRATyaLRILSHLVSYANSCVNPIVY 235
Cdd:cd15057  212 tnPDSSLRSSLRRETKALKTLSIIMGVFVCCWLPFFILNCVLPFcdlrtAQFPCVPDT--TFIVFVWLGWANSSLNPIIY 289
                        250
                 ....*....|.
gi 767996348 236 ALvSKHFRKGF 246
Cdd:cd15057  290 AF-NADFRKAF 299
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
34-244 2.04e-17

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 80.64  E-value: 2.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15185   65 WVFGHGMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELF 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPR----RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgARRAKRKVTRMILIVAALFC 189
Cdd:cd15185  145 EEFLCSPLYPEDTedswKRFHALRMNIFGLALPLLIMVICYTGIIKTLLRC---------PSKKKYKAIRLIFVIMVVFF 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 190 LCWMPHHALILCVWFGQFPL------TRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15185  216 IFWTPYNLVLLLSAFQSIFFetdcerSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRK 276
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
33-246 2.55e-17

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 80.20  E-value: 2.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIG--LIWGLSLLFSGPYLSYYRQS 110
Cdd:cd15173   63 EWIFGTVMCKITNGLYTINLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWGKVVctLVWVISLLLSLPQFIYSEVR 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLtVCHPAWSAPRRRAMDICT-FVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagSGARraKRKVTRMILIVAALFC 189
Cdd:cd15173  143 NLSSK-ICSMVYPPDAIEVVVNIIqMTVGFFLPLLAMIICYSVIIKTLLHA-------KGFQ--KHKSLKIIFVVVAVFI 212
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 190 LCWMPHHALILC--VWFGQFPLTRATYALrILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15173  213 LTQLPYNIMKLIrtLHIENTDSTNFKYAI-LITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
25-244 2.98e-17

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 80.20  E-value: 2.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAI--RYPLHSRELRTPRNALAAIGLIWGLSLLFSGP 102
Cdd:cd15177   55 FAAAETLQGWIFGNAMCKLIQGLYAINFYSGFLFLTCISVDRYVVIvrATSAHRLRPKTLFYSVLTSLIVWLLSILFALP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLSYYRQSQLANLTVCH----PAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPvaagsgarrAKRKVT 178
Cdd:cd15177  135 QLIYSRVENRSELSSCRmifpEVVSRTVKGATALTQVVLGFAIPLIVMAVCYAAIGRTLLAARGW---------ERHRAL 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 179 RMILIVAALFCLCWMPHHALIL---CVWFGQFPLTRATYALRILSHLVS----YANSCVNPIVYALVSKHFRK 244
Cdd:cd15177  206 RVIAALVVAFVLFQLPYSVVLLldtADLLATLELSCSQSKRKDIALLVTsglaYVRCCLNPLLYAFVGVRFRR 278
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
27-246 4.28e-17

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 80.07  E-value: 4.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS----- 100
Cdd:cd15051   58 AIYELRGeWPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSflpih 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 101 -GPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFvfsyLLPVLVLGLTY----------ARTLRYLWRAVDPVAAGSG 169
Cdd:cd15051  138 lGWNTPDGRVQNGDTPNQCRFELNPPYVLLVAIGTF----YLPLLIMCGVYlrifriareqAKRINALTPASTANSSKSA 213
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 170 ARRAKRKVTRMILIVAALFCLCWMPHhaLILCVWFGQFPLTRATYALRILSHLvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15051  214 ATAREHKATVTLAAVLGAFIICWFPY--FTYFTYRGLCGDNINETALSVVLWL-GYANSALNPILYAFLNRDFRRAF 287
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
34-244 6.02e-17

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 79.40  E-value: 6.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15158   66 WLFGDFLCRISSYALYVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTET 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRRR----AMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARrakRKVTRMILIVAALFC 189
Cdd:cd15158  146 NKTKCFEPPQSNQQLtkllVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKARKQQSSR---KKAIRMIIIVLLAFL 222
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 190 LCWMPHH-ALILCVWFGQFPLTRATYALRILSHLV-----SYANSCVNPIVYALVSKHFRK 244
Cdd:cd15158  223 VSFMPYHiQRTIHLHFLSRKDSTCEEVLYMQKSVVitlclAAANCCFDPLLYFFSGENFRR 283
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
29-246 6.97e-17

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 79.01  E-value: 6.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYY 107
Cdd:cd15060   60 YFLLGkWLFGIHLCQMWLTCDILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGW 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 RQSQlANLTVCHPAwSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRylwravdpvaAGSGARRAkrkvTRMILIVAAL 187
Cdd:cd15060  140 NDWP-ENFTETTPC-TLTEEKGYVIYSSSGSFFIPLLIMTIVYVKIFI----------ATSKERRA----ARTLGIIMGV 203
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 188 FCLCWMPHHALILCVWFGQ--FPLTRATYALRILshlvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15060  204 FVVCWLPFFLMYVILPFCEtcSPSAKVVNFITWL----GYVNSALNPVIYTIFNLDFRRAF 260
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
26-246 7.50e-17

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 79.07  E-value: 7.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYL 104
Cdd:cd15062   58 ATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISiGPLL 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SyYRQSQLANLTVChpawSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgarRAKRKVTRMILIV 184
Cdd:cd15062  138 G-WKEPAPADEQAC----GVNEEPGYVLFSSLGSFYLPLAIILVMYCRVYVVAFKF-----------SREKKAAKTLGIV 201
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 185 AALFCLCWMPHH-ALILCVWFGQFPLTRATYAlriLSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15062  202 VGAFVLCWFPFFvVLPLGSLFSTLKPPEPVFK---VVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
34-245 7.92e-17

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 79.35  E-value: 7.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQ-L 112
Cdd:cd15376   67 WRFGEAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEVeR 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWS---APRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVdpvaagSGARRAKRKVTRMILIVAALFC 189
Cdd:cd15376  147 HNKTECLGTAVdsrLPTYLPYSLFLAVVGCGLPFLLTLASYLAIVWAVLRSP------GITTLEKRKVAALVAVVVALYA 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 190 LCWMPHHAL------ILCVWFGQFPLTRATYALRILSHLVSYaNSCVNPIVYALVSKHFRKG 245
Cdd:cd15376  221 VSFVPYHILrnlnlyRRLQWLKAAASLRIYFAYQVTKGLVTL-NMCIHPLLYMAVADSIRLC 281
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
25-249 8.45e-17

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 78.84  E-value: 8.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP-- 102
Cdd:cd15299   60 FTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPai 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 -YLSYYRQSQLANLTVCH-PAWSAPrrrAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagsgarraKRKVTRM 180
Cdd:cd15299  140 lFWQYFVGKRTVPPDECFiQFLSEP---IITFGTAIAAFYLPVTIMTILYWRIYKETIK--------------EKKAAQT 202
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 181 ILIVAALFCLCWMPHHALILCVWFGQFPLTRATYAlriLSHLVSYANSCVNPIVYALVSKHFRKGFRTI 249
Cdd:cd15299  203 LSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWN---LGYWLCYINSTVNPVCYALCNKTFRTTFKML 268
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
25-244 9.24e-17

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 79.04  E-value: 9.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WAtIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIrypLHSRELRTPRNALA---AIGLIWGLSLLFSG 101
Cdd:cd15179   56 WA-VDAAANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAI---VHATNSQRPRKLLAekvVYVGVWLPALLLTV 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 102 PYLSYYRQSQLANLTVC--------HPAWsaprRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagsGARRA 173
Cdd:cd15179  132 PDLVFAKVSELDDRYICdriypedtFELW----VVAFRFQHILVGLVLPGLVILTCYCIIISKLSH---------SKGHQ 198
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 174 KRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHL-------VSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15179  199 KRKALKTTVILILAFFACWLPYYIGISIDTFMLLEIIKQSCEMEQTVHKwisiteaLAFFHCCLNPILYAFLGAKFKT 276
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
32-244 1.08e-16

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 78.67  E-value: 1.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQ 111
Cdd:cd15209   64 NGWTLGQLHCQASGFIMGLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFIGSLQY 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSAprRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTR--MILIVAALFC 189
Cdd:cd15209  144 DPRIYSCTFAQTV--STVYTITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPKLKPADVRNflTMFVVFVLFA 221
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 190 LCWMPHHALILCVWFGQFPLT-RATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15209  222 VCWAPLNFIGLAVAINPKEMApKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
34-246 1.18e-16

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 78.15  E-value: 1.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQla 113
Cdd:cd15059   66 WYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQ-- 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 nltvcHPAWSAPRRRAMDICTFVF-----SYLLPVLVLGLTYARTLRYlwravdpvaagsgARRAKRKVTRMILIVAALF 188
Cdd:cd15059  144 -----PWHGAEPQCELSDDPGYVLfssigSFYIPLLIMIIVYARIYRA-------------AKRKERRFTLVLGVVMGAF 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 189 CLCWMPhhalilcvWFGQFPLTRATYALRI------LSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15059  206 VLCWLP--------FFFTYPLVVVCKTCGVpellfkFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
32-246 1.31e-16

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 78.41  E-value: 1.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQ 111
Cdd:cd15402   64 NGWNLGYLHCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQY 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSAprRRAMDICTFVFSYLLPVLVLGLTYARtlryLWRAVDPVaagsgARRAK------------RKVTR 179
Cdd:cd15402  144 DPRIYSCTFAQSV--SSAYTIAVVFFHFILPIIIVTFCYLR----IWILVIQV-----RRRVKpdnkpklkphdfRNFVT 212
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 180 MiLIVAALFCLCWMPHHALILCVWFG-QFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15402  213 M-FVVFVLFAVCWAPLNFIGLAVAVDpETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
26-246 1.57e-16

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 78.08  E-value: 1.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDG-WVFGSLLCKavhflIFLTMH-----ASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLF 99
Cdd:cd15329   57 AIIYELSGyWPFGEILCD-----VWISFDvllctASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALI 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 100 SGPYLSYYRQSQLANlTVChpawSAPRRRAMDICTFVFSYLLPVLVLGLTYARtlryLWRAVdpvaagsgarRAKRKVTR 179
Cdd:cd15329  132 SIPPLFGWKNKVNDP-GVC----QVSQDFGYQIYATFGAFYIPLIVMLVLYYK----IYRAA----------KSERKAIK 192
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 180 MILIVAALFCLCWMPHhaLILCVWFGQFPLTRATYALRILSHLV---SYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15329  193 TLGIIMGAFTLCWLPF--FILALLRPFLKPIKCSCIPLWLSRLFlwlGYANSFLNPIIYAKFNREFRTPF 260
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
39-244 1.78e-16

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 78.30  E-value: 1.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  39 LLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVC 118
Cdd:cd15920   67 SFCKIVGAFFYLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFESRNEGPCDNKCF 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 119 HPAWSAPRRRAMDICTFVFSYLLPVLVLgLTYARTLRYLWRaVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHAL 198
Cdd:cd15920  147 HFRSKGLTAGGINLTAVVIFYILSLLFL-YFYAKISHKLYK-VSLGNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYHIV 224
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767996348 199 ILCVWFGQFPLTRAT---YALRILSHLV---SYANSCVNPIVYALVSKHFRK 244
Cdd:cd15920  225 RVPYVLAQIDVISSLpwkQTLHIANELVlclSALNSCLDPIIYFFLSSSFRR 276
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
29-243 2.01e-16

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 77.92  E-value: 2.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDG--WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPL-HSRelrtpRNALAAIGL---IWGLSLLFSGP 102
Cdd:cd15370   59 YHINGnnWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMsHSR-----KKANIAIGIslaIWLLILLVTIP 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLSYYRQSQLANL--TVCHPAwSAPRRRAMDICTFVFS-----YLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAkr 175
Cdd:cd15370  134 LYLVKQTVFIPALdiTTCHDV-LPEQLLVGDMFNYFLSlaigvFLFPAFLTAVAYVLMIRALKSSINDESIEKKRKRA-- 210
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 176 kvTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRAT-YALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15370  211 --IKLIVTVLVMYLICFTPSNLLLVVHYFLLKNQGQSSvYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
40-246 2.06e-16

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 78.32  E-value: 2.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  40 LCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALaAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCH 119
Cdd:cd15385   72 LCRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQPTKRSYL-MIGSAWALSFILSTPQYFIFSLSEIENGSGVY 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 120 PAWS------APRRRAMDICTFVFsyLLPVLVLGLTYARTLRYLWRAVD-------------------PVAAGSGARRAK 174
Cdd:cd15385  151 DCWAnfivpwGIKAYITWITISIF--VVPVIILLTCYGFICYNIWRNIKcktrrglsdnalknillavCVSSVKTISRAK 228
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 175 RKVTRMILIVAALFCLCWMPHHAL-ILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15385  229 IRTVKMTFVIVLAYIVCWAPFFTIqMWSVWDQNFPWDESENTAVTITALLASLNSCCNPWIYMFFSGHLLQDF 301
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
38-243 2.99e-16

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 77.56  E-value: 2.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  38 SLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTV 117
Cdd:cd14989   68 AVLCTFMSLFLQINMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHTGEVHF 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 118 CHPawSAPRRRAMDIctfVFSYLLPVLVLGLTYARTLRYLWRAvdpvAAGSGARRAKRKVTRMILIVAALFCLCWMPHHA 197
Cdd:cd14989  148 CFA--DVREIQWLEV---TLGFIIPFSIIGLCYSLIVRVLVRA----QKHRRLRPRRQKALRMILVVVLVFFICWLPENV 218
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 198 LILCVWF--GQFPLTRATYALR----ILSHLV---SYANSCVNPIVYALVSKHFR 243
Cdd:cd14989  219 FISIQLLqgTQEPSESYDESFRhnhpLTGHIVnlaAFSNSCLNPLIYSFLGETFR 273
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
34-243 3.36e-16

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 77.52  E-value: 3.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSyyrQSQLA 113
Cdd:cd15199   66 WSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLL---ASQPK 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRRRAMDI---CTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTrmilIVAALFCL 190
Cdd:cd15199  143 NFTECNSFSPKDDEDFSDTwqeAVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDVGKQPKLQRAMALVT----SVVVVFGF 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 191 CWMPHH-ALILCVWFGQFPLTRatyALRILSHL------VSYANSCVNPIVYALVSKHFR 243
Cdd:cd15199  219 CFLPCFlARVLMLIFQNKESCN---ALNIAVHTydvtmcLTYLNSVLDPIVYCFSSPTFR 275
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
34-243 3.45e-16

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 77.49  E-value: 3.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR--QSQ 111
Cdd:cd14987   66 WPMGEFTCKITHLIFSINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKtvTSP 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSAPRRR----AMDICTFVFSYLLPVLVLGLTY---ARTLRylwravdpvAAGSGARRAKRKVtrmILIV 184
Cdd:cd14987  146 SNNETYCRSFYPEESFKewliGMELVSIVLGFVIPFPIIAVFYfllARAIS---------ASSDQERKSSRKI---IFSY 213
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 185 AALFCLCWMPHHALIL--CVWFGQF-----PLTRATYALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd14987  214 VVVFLVCWLPYHTVVLldILSFLHLipfscQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
28-244 4.32e-16

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 77.18  E-value: 4.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTL-DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRElrTPRNALAAIGLIWGLSLLFSGPYLSY 106
Cdd:cd15396   59 VYTLmDHWIFGETMCKLTSFVQSVSVSVSIFSLVLIAIERYQLIVNPRGWKP--SASHAYWGIVLIWLFSLMISIPFLIF 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSQ--LANLT----------VCHPAW-SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWR---AVDPVAAGSGA 170
Cdd:cd15396  137 HQLTDepFRNLSshsdfykdkvVCIEAWpSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKrnsKIDRMRENESR 216
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 171 RRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRI-LSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15396  217 LSENKRINTMLISIVVTFAACWLPLNIFNVVFDWNHEVLMSCHHNLVFtLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
34-237 4.49e-16

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 77.15  E-value: 4.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY---------- 103
Cdd:cd15118   65 WELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYfvfrdvierk 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 ----LSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYArtlrylwrAVDPVAAGSGARRAKRkVTR 179
Cdd:cd15118  145 dgrkLCYYNFALFSPSPDNNHPICKQRQEGLAISKLLLAFLIPLVIIAVSYA--------VVSLIIRHRCRRRPGR-FVR 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 180 MILIVAALFCLCWMPHHALILC-----VWFGQFPLTRAtyALRILSHLvSYANSCVNPIVYAL 237
Cdd:cd15118  216 LVVSVVVSFALCWAPYHIFSIIevmahNQHSLRPLVIQ--GLPFATTL-AFLNSVLNPVLYVF 275
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
34-246 4.68e-16

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 77.58  E-value: 4.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL----SYYRQ 109
Cdd:cd15355   71 WAFGDAACRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLftmgEQNRS 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 SQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLV---LGLTYARTLRYL---------------WRAVDPVAAGSGAR 171
Cdd:cd15355  151 GTHPGGLICTPIVDTSTLKVVIQVNAFLSFLFPMLVisvLNTLIANQLTVMvnqaeqenqvctiggQRTVLSVSMEPGRV 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 172 RAKRKVTRMILIVAALFCLCWMPHHA--LILCV---WFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15355  231 QSLRHGVLVLRAVVIAFVVCWLPYHVrrLMFCYvsdEQWTTFLYDFYHYFYMLTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
29-239 4.80e-16

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 77.20  E-value: 4.80e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP---YLS 105
Cdd:cd15156   60 FVQRNWPFGDLLCKISVTLFYTNMYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPasfFQS 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTvCHPAWSAPRRRAM--DICTFV--FSYLLPVLVLGLTYARTLRYLWRavdPVAAgSGARRAKRKVTRMI 181
Cdd:cd15156  140 TNNQLNNNSET-CFENFSSKTWKTYlsKIVIFIeiVGFFIPLILNVTCSTMVLKTLRR---PNTL-SRSKLNKKKVLKMI 214
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 182 LIVAALFCLCWMPH------HALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVS 239
Cdd:cd15156  215 FVHLFIFCFCFIPYnvnlvlYSLVRTQTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTS 278
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
39-242 4.85e-16

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 77.15  E-value: 4.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  39 LLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLhsRELRTP-RNALAAIGLIWGLSLLFSGPYL---SYYRQSQLAN 114
Cdd:cd15386   71 LLCRAVKYLQVLSMFASTYMLIMMTVDRYIAVCHPL--RTLQQPsRQAYLMIGATWLLSCILSLPQVfifSLREVDQGSG 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 115 LTVC----HPAWSAprrRAMDICTFVFSYLLPVLVLGLTYA-------RTLRYLWRAVDPVAAGSGAR------------ 171
Cdd:cd15386  149 VLDCwadfGFPWGA---KAYITWTTLSIFVLPVAILIVCYSlicyeicKNLKGKTQTSRSEGGGWRTQgmpsrvssvrti 225
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 172 -RAKRKVTRMILIVAALFCLCWMPHHAL-ILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHF 242
Cdd:cd15386  226 sRAKIRTVKMTFVIVLAYIACWAPFFSVqMWSVWDENAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
27-246 4.92e-16

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 76.60  E-value: 4.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL- 104
Cdd:cd15300   58 TSYILMGyWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPIl 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 --SYYRQSQLANLTVCHPAW-SAPrrrAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagsgarraKRKVTRMI 181
Cdd:cd15300  138 cwQYFVGKRTVPERECQIQFlSEP---TITFGTAIAAFYIPVSVMTILYCRIYKETIK--------------ERKAAQTL 200
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 182 LIVAALFCLCWMPHHALILCVWFGQ--FPLTratyaLRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15300  201 SAILLAFIITWTPYNIMVLVSTFCSdcIPLT-----LWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
28-243 6.77e-16

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 77.75  E-value: 6.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYT-LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSY 106
Cdd:PHA02638 154 IYNeFDQWIFGDFMCKVISASYYIGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFI 233
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQS------QLANLTVCHPAWSAPRRRAMDICTF----------VFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgA 170
Cdd:PHA02638 234 FEASniifsaQDSNETISNYQCTLIEDNEKNNISFlgrilqfeinILGMFIPIIIFAFCYIKIILKLKQL---------K 304
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 171 RRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFP------------LTRATYALrILSHLVSYANSCVNPIVYALV 238
Cdd:PHA02638 305 KSKKTKSIIIVSIIIICSLICWIPLNIVILFATMYSFKgfnsiisehicgFIKLGYAM-MLAEAISLTHCCINPLIYTLI 383

                 ....*
gi 767996348 239 SKHFR 243
Cdd:PHA02638 384 GENFR 388
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
36-239 6.98e-16

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 76.31  E-value: 6.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  36 FGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL---SYYRQSQL 112
Cdd:cd14964   66 RPQALCYLIYLLWYGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLvgkGAIPRYNT 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHpaWSAPRRRAMDICTFVFsyLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKR-KVTRMILIVAALFCLC 191
Cdd:cd14964  146 LTGSCYL--ICTTIYLTWGFLLVSF--LLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNlKATKSLLILVITFLLC 221
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767996348 192 WMPHhaLILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVS 239
Cdd:cd14964  222 WLPF--SIVFILHALVAAGQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
34-244 7.16e-16

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 76.58  E-value: 7.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSREL-RTPRNALAAiglIWGLSLLFSGPYLSYYRQSQl 112
Cdd:cd15382   67 WLAGDFLCRLMLFFRAFGLYLSSFVLVCISLDRYFAILKPLRLSDArRRGRIMLAV---AWVISFLCSIPQSFIFHVES- 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 anltvcHPA---------WSAPRRRAMDICTFVFS----YLLPVLVLGLTYARTLRYLWRAV-----DPVAAGSGAR--- 171
Cdd:cd15382  143 ------HPCvtwfsqcvtFNFFPSHDHELAYNIFNmitmYALPLIIIVFCYSLILCEISRKSkekkeDVSEKSSSVRlrr 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 172 -------RAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15382  217 ssvglleRARSRTLKMTIVIVLVFIICWTPYFIMSLWYWFDRESASKVDPRIQKGLFLFAVSNSCMNPIVYGYFSIDLRR 296
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
31-246 7.75e-16

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 76.17  E-value: 7.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQS 110
Cdd:cd15330   63 LNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTP 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 Q-LANLTVChpawSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRylwravdpvaagsgARRAKRKVTRMILIVAALFC 189
Cdd:cd15330  143 EdRSDPDAC----TISKDPGYTIYSTFGAFYIPLILMLVLYGRIFK--------------AAARERKTVKTLGIIMGTFI 204
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 190 LCWMPHHALILCVWFGQFPLTRATYALRILSHLvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15330  205 LCWLPFFIVALVLPFCESTCHMPELLGAIINWL-GYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
25-243 7.86e-16

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 76.36  E-value: 7.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WAtIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd15188   57 WA-MYVAWHWVFGSFLCKFVSTLYTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDM 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYRQSQLANLT-VCH-------PAWSAPRRRAMDICTFvfsyLLPVLVLGLTYARTLRYLWRAVDPvaagsGARRAkrk 176
Cdd:cd15188  136 VFVQTHHTNNGVwVCHadygghhTIWKLVFQFQQNLLGF----LFPLLAMVFFYSRIACVLTRLRPP-----GQGRA--- 203
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 177 vTRMILIVAALFCLCWMPH------HALILCVWFGQFPLTRA-TYALRIlSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15188  204 -LRFVAALVVVFFVLWFPYnltlflHSLQDLHVIGNCERSRHlDYALQV-TESLAFVHCCLNPLLYAFVSKRFR 275
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
32-235 1.01e-15

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 76.38  E-value: 1.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSrelRTPRNALAAIGliWGLSLLFSGPYLSYYR--- 108
Cdd:cd15198   65 DRWMAGDVACRLLKLLQASARGASANLVVLLALDRHQAIRAPLGQ---PLRAWKLAALG--WLLALLLALPQAYVFRvdf 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 ----QSQLANLTVCH------PAWsapRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLW----------------RAVD 162
Cdd:cd15198  140 pddpASAWPGHTLCRgifaplPRW---HLQVYATYEAVVGFVAPVVILGVCYGRLLLKWWeranqapgakkpwkkpSKSH 216
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 163 PVA-AGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATY--ALRILshlvSYANSCVNPIVY 235
Cdd:cd15198  217 LRAtAPSALPRAKVKTLKMTLVIALLFVGCSLPYFIAELAAAFGSGDWEPEKVaaALGVM----AVANSATNPFVF 288
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
34-247 1.12e-15

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 75.76  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGL-----SLLFSGPYLSYYR 108
Cdd:cd15170   67 WPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLafshcSIVYIVEYHIDSE 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVCHPAWSA-------PRRRAMdictFVFSYLLPVLVLGLTYARTLRYLwravdpVAAGSGARRAKRKVTRMI 181
Cdd:cd15170  147 NTSVTNNSRCYDNFTPeqlkillPVRLEL----FLVLFCIPFLITCFCYINFIRIL------SSLPHISRQRKQRAIGLA 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 182 LIVAALFCLCWMPHHALILcVWF--GQFPLTRaTYALrilshLVSYANSCVNPIVYALVSKHFRKGFR 247
Cdd:cd15170  217 VATLLNFIVCFAPYNISHV-VGFiqRKSPEWR-MYAL-----LLSTLNACLDPIIFYFSSSAVRRAFK 277
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
34-246 1.19e-15

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 75.97  E-value: 1.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSyYRQSQLA 113
Cdd:cd15364   66 WPWGSLACKITGYIFFCNIYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFI-MREGQTE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRRRA-MDICTFVFSYLLPVLVLGLTYARTLRYLWRAVdpvaagSGARRAKRKVTRMILIVAALFCLCW 192
Cdd:cd15364  145 GSHTCFETLQMDTQVAgFYYARFCIGFAIPLAILIFTNYRIFRSIQTST------SLTPHQKAKVKYLAIAVIVIFLICF 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 193 MPHHALIL--CVWF-----GQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15364  219 APYHLVLLvrAIAFslypnGMCGFEERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
58-243 1.32e-15

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 75.58  E-value: 1.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  58 TLAAVSLDRYLAIRYPLHSRELrTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANL-TVCHPAW--SAPRRRAMDICT 134
Cdd:cd15075   90 TVAVIAVDRLFVVCKPLGTLTF-QTRHALAGIASSWLWSLIWNTPPLFGWGSYQLEGVmTSCAPDWysRDPVNVSYILCY 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 135 FVFSYLLPVLVLGLTYARTLRYLWR-AVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGqfPLTRAT 213
Cdd:cd15075  169 FSFCFAIPFAIILVSYGYLLWTLRQvAKLGVAEGGSTAKAEVQVARMVVVMVMAFLLCWLPYAAFALTVVSK--PDVYIN 246
                        170       180       190
                 ....*....|....*....|....*....|
gi 767996348 214 YALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15075  247 PLIATVPMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
25-244 1.41e-15

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 75.56  E-value: 1.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATiYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd15184   56 WAH-YAANEWVFGNAMCKLLTGLYHIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGI 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYRQSQLANLTVCHPAWSAPRRRA----MDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPvaagsgarRAKRKVTRM 180
Cdd:cd15184  135 IFTKSQKEGSHYTCSPHFPPSQYQFwknfQTLKMNILGLVLPLLVMIICYSGILKTLLRCRNE--------KKRHKAVRL 206
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 181 ILIVAALFCLCWMPHHALILCVWFGQF----------PLTRATYALRILshlvSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15184  207 IFTIMIVYFLFWAPYNIVLLLNTFQEFfglnncsssnRLDQAMQVTETL----GMTHCCINPVIYAFVGEKFRS 276
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
25-246 1.43e-15

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 75.56  E-value: 1.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WAtIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTprNALAAIGLI----WGLSLLFS 100
Cdd:cd15172   56 WA-VYEAHQWIFGNFSCKLLRGIYAINFYSGMLLLACISVDRYIAIVQATKSFRLRS--RTLAYSKLIcaavWLLAILIS 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 101 GPYLSYYR--QSQLANLTVCHPA----WSAPRRRAMDICTFV-FSYLLPVLVLGLTYARTLRYLWRavdpvaagsgARRA 173
Cdd:cd15172  133 LPTFIFSEvyDFGLEEQYVCEPKypknSTAIMWKLLVLSLQVsLGFFIPLLVMIFCYSFIIKTLLQ----------AQNS 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 174 KR-KVTRMILIVAALFCLCWMPHHaLILCVWFGQFPLTRATYALRILSH------LVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15172  203 QRhKAVRVVVAVVLVFLVCQVPYN-IVLLIEAINLGEQQSCSSEKAVAYaktiteCLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
34-244 1.66e-15

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 75.61  E-value: 1.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15374   66 WPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKD 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPR-RRAMDICTFVFSYL--LPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVtRMILIVAALFCL 190
Cdd:cd15374  146 NITLCHDTTRPEEfDHYVHYSSAVMVLLfgIPCLVIVVCYGLMARRLCKPRVGSSRQQGPSSKKRSL-KTIIMVLTVFAI 224
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 191 CWMPHHALILCVWFGQF------PLTRATYALRILSHLVSyANSCVNPIVYALVSKHFRK 244
Cdd:cd15374  225 CFVPFHITRTLYYVARLlkadcdTLNIINVTYKVTRPLAS-ANSCLDPILYFLAGDKYRR 283
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
31-249 1.69e-15

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 76.10  E-value: 1.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGlIWGLSLLFSGPYLSYYRQS 110
Cdd:PHA02834  88 LNEWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNATKIKNKSISLSVLLSVA-AWVCSVILSMPAMVLYYVD 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTVC-------HPAWSAPRRRAMDIctfvFSYLLPVLVLGLTYARTLrylwravdpVAAGSGARRAKRKVTRMILI 183
Cdd:PHA02834 167 NTDNLKQCifndyheNFSWSAFFNFEINI----FGIVIPLIILIYCYSKIL---------YTLKNCKNKNKTRSIKIILT 233
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 184 VAALFCLCWMPHHALILC--------VWFGQFPLTRATYALRILsHLVSYANSCVNPIVYALVSKHFRKGFRTI 249
Cdd:PHA02834 234 VVTFTVVFWVPFNIVLFInslqsvglIDIGCYHFKKIVYSIDIA-ELISFVHCCVNPIIYAFVGKNFKKVFKNM 306
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
27-244 1.71e-15

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 75.25  E-value: 1.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSY 106
Cdd:cd15186   57 THYLINEWGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMF 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSQLANL----TVCHPAWSAPRRRAMDICTFvfsyLLPVLVLGLTYARTLRYLWravdpvaagSGARRAKRKVTRMIL 182
Cdd:cd15186  137 TKMKENECLgdypEVLQEIWPVLRNVELNFLGF----LLPLLIMSYCYFRIIQTLF---------SCKNHKKARAIKLIL 203
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 183 IVAALFCLCWMPHHALILCV---WFGQFPLTRATYALRILSHL---VSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15186  204 LVVIVFFLFWTPYNVMIFLEtlkLYDFFPSCDMKKDLRLALSVtetIAFSHCCLNPLIYAFAGEKFRR 271
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
57-244 2.41e-15

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 75.22  E-value: 2.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  57 FTLAAVSLDRYLAIRYPLHSRELRTpRNALAAIGLIWGLSLLFSGPYL---SYYRQSQLAnlTVCHPAW--SAPRRRAMD 131
Cdd:cd15082  102 WSLAVLAFERFFVICRPLGNIRLQG-KHAALGLLFVWTFSFIWTIPPVlgwSSYTVSKIG--TTCEPNWysGNMHDHTYI 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 132 ICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVwfGQFPLTR 211
Cdd:cd15082  179 ITFFTTCFILPLGVIFVSYGKLLQKLRKVSNTQGRLGNARKPERQVTRMVVVMIVAFMVCWTPYAAFSILV--TAHPTIH 256
                        170       180       190
                 ....*....|....*....|....*....|...
gi 767996348 212 ATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15082  257 LDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRK 289
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
46-246 4.51e-15

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 74.20  E-value: 4.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  46 FLIFLTmHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYLSYYRQSQLANltvcHPAWSA 124
Cdd:cd15068   77 FVLVLT-QSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGlTPMLGWNNCGQPKE----GKNHSQ 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 125 PRRRAMDICTF----VFSY----------LLPVLVLGLTYARTL----RYLWRAVDPVAAGSGARRAKRK---VTRMILI 183
Cdd:cd15068  152 GCGEGQVACLFedvvPMNYmvyfnffacvLVPLLLMLGVYLRIFlaarRQLKQMESQPLPGERARSTLQKevhAAKSLAI 231
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 184 VAALFCLCWMPHHaLILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15068  232 IVGLFALCWLPLH-IINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
34-246 4.97e-15

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 74.13  E-value: 4.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPyLSYYRQSQLA 113
Cdd:cd15356   71 WVFGDLVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALP-MAFIMGQKYE 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLT----------VCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwravdpvaagsGARRAKRKVTRMILI 183
Cdd:cd15356  150 LETadgepepssrVCTVLVSRATLKVFIQVNAFVSFVLPLALIAFLNGVTVSHL-----------RIQSLQHSVQVLRAI 218
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 184 VAAlFCLCWMPHHA--LILC-----VWFGqfPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15356  219 VIA-YVICWLPYHArrLMFCyvpddAWTD--SLYNFYHYFYMLTNTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
28-244 5.46e-15

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 74.08  E-value: 5.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTL-DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIrypLHSRELR-TPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15395   59 VYTLmDHWVFGEAMCKLNSMVQCISITVSIFSLVLIAIERHQLI---INPRGWRpNNRHAYVGIAVIWVLAVLTSLPFLI 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYR------------QSQLANLTVCHPAW-SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWR---AVDPVAAGSG 169
Cdd:cd15395  136 FQVltdepfknvnvsLDAYKGKYVCLDQFpSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRrnnMMDKMRDNKY 215
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 170 ARRAKRKVTRMILIVAALFCLCWMPHHALILCV-WFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15395  216 RSSETKRINIMLISIVVAFAVCWLPLNIFNAVFdWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQR 291
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
34-246 7.76e-15

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 73.43  E-value: 7.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKaVH--FLIFLTMhASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLS------LLFSGPYLS 105
Cdd:cd15314   66 WYFGDLFCK-IHssFDITLCT-ASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSalvgfgIIFLELNIK 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHPAWSaprrRAMDICTFVFSYLLPVLVLGLTYARTL---RYLWRAVDPVAAGSGA--RRAKRKVTRM 180
Cdd:cd15314  144 GIYYNHVACEGGCLVFFS----KVSSVVGSVFSFYIPAVIMLCIYLKIFlvaQRQARSIQSARTKSGAssSKMERKATKT 219
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 181 ILIVAALFCLCWMPhhaLILCVWFgqFPLTRATYALRILSHLV--SYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15314  220 LAIVMGVFLLCWTP---FFLCNII--DPFINYSIPPVLIEVLNwlGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
34-245 1.45e-14

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 72.56  E-value: 1.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLH---SRElrtprNALAAIGLIWGLSLLFSGPYLSYYRQS 110
Cdd:cd15008   65 WTLGSAMCKLVRYFQYLTPGVQIYVLLSICVDRFYTIVYPLSfkvSRE-----KAKKMIAASWLFDAAFVSPALFFYGSN 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTVCHP-AWSAPrrrAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaAGSGAR----------RAKRKVTR 179
Cdd:cd15008  140 WGPHCNFFLPdSWDGA---AYAIIHLLVGFLVPSILIILFYQKVIKYIWR------IGTDGRtvrrtmnivpRTKVKTIK 210
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 180 MILIVAALFCLCWMPHHALILcvWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKG 245
Cdd:cd15008  211 MFLMLNSMFLLSWLPFYVVQL--WHPRESDYRQSSLVFLAVTWISFSSSASKPTLYSVYNANFRRG 274
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
34-244 1.56e-14

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 72.64  E-value: 1.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15377   66 WIFGDAMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRK 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTV-CHPAWSAPRRRAMDI---CTFVFSYLLPVLVLGLTYARTLRYLWRAvDPVAAGSGARRAKRKVTRMILIVAALFC 189
Cdd:cd15377  146 NKTItCYDTTSDEYLRSYFIysmCTTVAMFCVPFILILGCYGLIVRALIYK-DMKYTEENNAPLRRKSIYLVIIVLTVFA 224
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 190 LCWMPHHAL----ILCVWFGQFP----LTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15377  225 VSYLPFHVMktlnLRARLDFQTPamcaFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRR 287
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
32-244 1.88e-14

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 72.60  E-value: 1.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAI-GLIWGLSLLFSGPYLSYYRQS 110
Cdd:cd15379   64 DYWPFGDFTCRLVRFQFYTNLHGSILFLTCISVQRYLGICHPLASWHKKKGKKLTWLVcGAVWLVVIAQCLPTFVFASTG 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTVCHPAwSAPRRRA----MDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAA 186
Cdd:cd15379  144 TQRNRTVCYDL-SPPARSTayfpYGITLTRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPGEKRGKAARMIIVVAA 222
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 187 LFCLCWMPHH---ALILCVWF---GQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15379  223 VFLISFLPFHytkTRYLQVRSwdgGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRP 286
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
26-246 1.90e-14

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 72.14  E-value: 1.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15063   58 AVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLV 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYrQSQLANLTVCHPAWSAPRR------RAMDICTFVFSYLLPVLVLGLTYARTLRylwravdpvaagsgARRAKRKVTR 179
Cdd:cd15063  138 GW-NDGKDGIMDYSGSSSLPCTceltngRGYVIYSALGSFYIPMLVMLFFYFRIYR--------------AARMETKAAK 202
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 180 MILIVAALFCLCWMPHHALILCVWFGQFPLTRATYAlriLSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15063  203 TVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPPLLFS---VFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
40-245 1.92e-14

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 72.50  E-value: 1.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  40 LCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALaAIGLIWGLSLLFSGPYLSYYRQSQLA-NLTVC 118
Cdd:cd15388   72 LCRLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNG-PVCVAWAISLILSLPQVFIFSKVEVApGVYEC 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 119 HPAWSAP-RRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPV------------------AAGSGARRAKRKVTR 179
Cdd:cd15388  151 WACFIEPwGLKAYVTWITLVVFVLPTLIITVCQVLIFKEIHINIYLKsqiivavvkkkqllssraSSVAEVSKAMIKTVK 230
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 180 MILIVAALFCLCWMPHHALIL-CVWFGQFPLTRATYALRILshLVSYaNSCVNPIVYALVSKHFRKG 245
Cdd:cd15388  231 MTLVIVLVYVLCWAPFFLVQLwSVWDPKAPTEGATFTILML--LASL-NSCTNPWIYMAFSSSVSKE 294
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
28-242 2.36e-14

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 71.91  E-value: 2.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLfsgpYLSYY 107
Cdd:cd15164   57 LYFLKHSWPDDELCLVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVLVII----SVSLR 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 RQSQLANLTVC-HPAWSAPRRRAMdiCTFVFSYLLPVLVLGLTYARTLRYLWR--AVDPvaagsGARRAKRKVTRMILIV 184
Cdd:cd15164  133 LAWEEQEENFCfGKTSTRPSKRTL--IFSLLGFFIPLIILSFCSIQVIRSLKKkkKTNP-----HEEKLIQKAIYIVSAN 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 185 AALFCLCWMPHH-ALILCVWFGQ-----FPLTRATYALRILShLVSYANSCVNPIVYALVSKHF 242
Cdd:cd15164  206 LIVFIVCFLPLHiGLLVRFVMESnkascSLIQNIRNFIYVAS-CLANANCCLDAICYYFVAKEF 268
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
25-244 2.46e-14

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 72.09  E-value: 2.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATiYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAI--GLIWGLSLLFSGP 102
Cdd:cd15174   56 WAT-AASSGWVFGTFLCKVVNSMYKINFYSCMLLLTCISVDRYIAIVQATKAHNSKNKRLLYSKLvcFFVWLLSTILSLP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFV----FSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgARRAKRKVT 178
Cdd:cd15174  135 EILFSQSKEEESVTTCTMVYPSNESNRFKVAVLAlkvtVGFFLPFVVMVICYTLIIHTLLQA---------KRFQKHKAL 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 179 RMILIVAALFCLCWMPHHAlILCVWFGQF---------PLTRATYALRILSHlVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15174  206 KVIIAVVTVFVLSQLPYNS-ILLIKTINAynititdcaTSQNLDIAGQVTQS-IAFLHSCLNPFLYVFVGVRFRK 278
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
27-246 2.48e-14

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 71.78  E-value: 2.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL- 104
Cdd:cd15301   58 TVYTALGyWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIy 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 --SYYRQSQLANLTVCHPAWsAPRRRAMDICTFVFSYLLPVLVLGLTYARtlryLWRAVDpvaagSGARRAKRKVTRMIL 182
Cdd:cd15301  138 swPYIEGKRTVPAGTCYIQF-LETNPYVTFGTALAAFYVPVTIMCILYWR----IWRETK-----KRQKKQESKAAKTLS 207
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 183 IVAALFCLCWMPHHALILCVWFGQFPLTRATYaLRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15301  208 AILLAFIVTWTPYNVLVLIKAFFPCSDTIPTE-LWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
47-246 2.68e-14

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 71.94  E-value: 2.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSG-PYLSYyrQSQLANLTVCHPAwSAP 125
Cdd:cd14972   76 SLVLSLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALlPVLGW--NCVLCDQESCSPL-GPG 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 126 RRRAMDICTFVFsYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRM-----ILIVAALFCLCWMP---HHA 197
Cdd:cd14972  153 LPKSYLVLILVF-FFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQPSTSRklaktVVIVLGVFLVCWLPlliLLV 231
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767996348 198 LILCVWFGQFPLTRATYALrilshLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14972  232 LDVLCPSVCDIQAVFYYFL-----VLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
32-246 3.05e-14

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 71.64  E-value: 3.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQ 111
Cdd:cd15375   64 ESWIFGEFMCKFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKE 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSAPRRRAMD----ICTfVFSYLLPVLVLGLTYartlrylWRAVDPVAAGSGARRAKR-KVTRMILIVAA 186
Cdd:cd15375  144 KNNRTICLDFTSSDNLNTIWwynwILT-VLGFLLPLVIVTLCY-------TRIIYTLAKGPHTGSASKqKARRLIILILL 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 187 LFCLCWMPHHAL-ILCVWFGQFP----LTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15375  216 VFYVCFLPFHILrVVRIETRLPPvsccLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
25-246 3.09e-14

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 72.10  E-value: 3.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPY 103
Cdd:cd15058   57 GATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSfVPI 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQSQLANLTVCH--PAWSAPR-RRAMDICTFVFSYLLPVLVLGLTYART---------------LRYLWRAVDPVA 165
Cdd:cd15058  137 MNQWWRANDPEANDCYqdPTCCDFRtNMAYAIASSVVSFYIPLLIMIFVYARVfliatrqlqlidkrrLRFQSECPAPQT 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 166 AGS-GARRAKRKVTRMIL-----------IVAALFCLCWMPHH-ALILCVWFGQFPltrATYALRILSHLvSYANSCVNP 232
Cdd:cd15058  217 TSPeGKRSSGRRPSRLTVvkehkalktlgIIMGTFTLCWLPFFiANIINVFNRNLP---PGEVFLLLNWL-GYINSGLNP 292
                        250
                 ....*....|....
gi 767996348 233 IVYALvSKHFRKGF 246
Cdd:cd15058  293 IIYCR-SPEFRTAF 305
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
34-246 3.45e-14

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 71.51  E-value: 3.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL-SYYRQSQL 112
Cdd:cd15323   66 WYFGQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLiSMYRDPEG 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCH---PAWSAprrramdICTFVFSYLLPVLVLGLTYARTLRYlwravdpvaagsgARRAKRKVTRMILIVAALFC 189
Cdd:cd15323  146 DVYPQCKlndETWYI-------LSSCIGSFFAPCLIMILVYIRIYRV-------------AKAREKRFTFVLAVVMGVFV 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 190 LCWMP----HHALILCVWFGQFPLTRATYALRIlshlvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15323  206 VCWFPfffsYSLYGICREACEVPEPLFKFFFWI-----GYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
33-237 3.73e-14

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 71.45  E-value: 3.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELrTPRNALAAIGLIWGLSLLFS-GPYL---SYYr 108
Cdd:cd15079   64 GWALGPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNPL-TRGKALLLILFIWLYALPWAlLPLLfgwGRY- 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 qSQLANLTVC-----HPAWSAprrRAMDICTFVFSYLLPVLVLGLTYARTLRYLW---RAVDPVA-----------AGSG 169
Cdd:cd15079  142 -VPEGFLTSCsfdylTRDWNT---RSFVATIFVFAYVIPLIIIIYCYSFIVKAVFaheKALREQAkkmnvvslrsnADAN 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 170 ARRAKRKVTRMILIVAALFCLCWMPhHALIlcVWFGQF-PLTRATYALRILSHLVSYANSCVNPIVYAL 237
Cdd:cd15079  218 KQSAEIRIAKVALTNVFLWFIAWTP-YAVV--ALIGAFgNQSLLTPLVSMIPALFAKTAACYNPIVYAI 283
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
38-244 3.79e-14

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 71.46  E-value: 3.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  38 SLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELrTPRNALAAIGLIWGLSLLFSG------PYLSYYrqsq 111
Cdd:cd15137   77 SWLCTFAGFLATLSSEVSVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLLAVlpllpwDYFGNF---- 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHP-AWSAPRRRAMDICTFVFSYL--LPVLVLGLTYARTLRYLWRavdpvaAGSGARRAKRK-----VTRMILI 183
Cdd:cd15137  152 YGRSGVCLPlHITDERPAGWEYSVFVFLGLnfLAFVFILLSYIAMFISIRR------TRKAAASRKSKrdmavAKRFFLI 225
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 184 VAALFClCWMPHHALILCVWFGqFPLTRATYALRILshLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15137  226 VLTDFL-CWIPIIVIGILALSG-VPIPGEVYAWVAV--FVLPINSALNPILYTLSTPKFRK 282
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
32-246 3.80e-14

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 71.48  E-value: 3.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPylSYYRQSQ 111
Cdd:cd15401   64 NGWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVP--NFFVGSL 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARtlryLWRAVDPVAAgSGARRAKRKVTR-------MILIV 184
Cdd:cd15401  142 QYDPRIYSCTFAQTVSSSYTITVVVVHFIVPLSIVTFCYLR----IWVLVIQVKH-RVRQDSKQKLKAndirnflTMFVV 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 185 AALFCLCWMPHHALILCVWFGQFPLT-RATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15401  217 FVLFAVCWGPLNFIGLAVAINPLKVApKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
32-239 4.18e-14

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 71.35  E-value: 4.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL----SYY 107
Cdd:cd15365   64 DNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILtwedSFH 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 RQSqlaNLTVCHPAWS-APRRRAMDICTFVFSYLLPVLVLGLTYARtlryLWRAVDPVAAgsGARRAKRKVTRMILIVAA 186
Cdd:cd15365  144 ESS---SHTLCYDKFPlEDWQARLNLFRICLGYLLPLLIILFCYWK----IYQAVRSNQA--TEDQEKKKIFKLLLLITV 214
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 187 LFCLCWMPHHALILC---VWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVS 239
Cdd:cd15365  215 TFVICFTPYHVVLLIrsiVEPCDCRNAKWLYTLYKITVALTSLNCIADPFLYCFVT 270
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
34-246 4.19e-14

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 71.75  E-value: 4.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRtPRNALAAIGLIWGLSLLFSGPYL--------- 104
Cdd:cd15135   71 TPSGNIACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALS-GSRVRLLICFVWLTSALVALPLLfamgtedpl 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 ---------SYYRQSQLANLTVCHPAWSA-PRRRAMDICTFVFsYLLPVLVLGLTYARTLRYLWRAVDPVAAGSG----- 169
Cdd:cd15135  150 eafpsyrgtRHHCQDQKSNLTICTSLSSKwTVFQASIFSAFVL-YLLVLASVAFMCRRMMRALMGSKKGAVAVKGpggsv 228
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 170 ----------ARRAKRKVTRMI-LIVAALFcLCWMPHHA-LILCVWFGQFPLTRATYALRILSHLVS----YANSCVNPI 233
Cdd:cd15135  229 qllrkhesaeGKTARKQTILFLgLIVGTLA-VCWMPNQIrRIMAAAKPKDDWTRSYFRAYIILLPIAdtffYLSSVLNPL 307
                        250
                 ....*....|...
gi 767996348 234 VYALVSKHFRKGF 246
Cdd:cd15135  308 LYNLSSQQFRSVF 320
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
34-244 4.48e-14

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 71.29  E-value: 4.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL---SYYRQS 110
Cdd:cd15336   66 WIFGEKGCELYAFCGALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLfgwSAYVPE 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLanLTVChpAW----SAPRRRAMDICTFVFSYLLPVLVLGLTYA---RTLRYLWRAVDPVAAGSGARRAKR-------- 175
Cdd:cd15336  146 GL--LTSC--TWdymtFTPSVRAYTMLLFCFVFFIPLGIIIYCYLfifLAIRSTGREVQKLGSQDRKEKAKQyqrmknew 221
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 176 KVTRMILIVAALFCLCWMPHHALILCVWFGqfpltratYAlrilSHLVSYANSC----------VNPIVYALVSKHFRK 244
Cdd:cd15336  222 KMAKIAFVVILLFVLSWSPYACVALIAWAG--------YA----HLLTPYMKSVpaviakasaiYNPIIYAITHPKYRE 288
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
25-244 4.61e-14

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 71.44  E-value: 4.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLD-GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd15925   57 WAVESALDfHWPFGGAMCKMVLTATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPT 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQSQLANLTVChpAWSAPRRR---AMDICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvAAGSGARRAKRKVTRM 180
Cdd:cd15925  137 AIFATEGEVCGVELC--LLKFPSNYwlgAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQH----KVNQNNRQRQSVIARS 210
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 181 ILIVAALFCLCWMPHHALIL---CVWFGQFPLTRATYALRI----LSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15925  211 VRLVVASFFLCWFPNHVVTFwgvLVKFRAVPWNSTFYFIHTyvfpVTTCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-246 5.08e-14

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 71.42  E-value: 5.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTL--DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP-- 102
Cdd:cd15976   57 NVYKLlaEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPea 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 -----YLSYYRQSQLaNLTVCHPAWSAP----RRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVA-AGSGARR 172
Cdd:cd15976  137 igfdmITMDYKGELL-RICLLHPIQKTAfmqfYKTAKDWWLFSFYFCLPLACTAVFYTLMTCEMLRKKNGMQiALNDHLK 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 173 AKRKVTRMILIVAALFCLCWMPHH---ALILCVWFGQFP----LTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKG 245
Cdd:cd15976  216 QRREVAKTVFCLVLVFALCWLPLHlsrILKLTIYDEKDPnrceLLSFFLVLDYIGINMASLNSCINPIALYLVSKRFKNC 295

                 .
gi 767996348 246 F 246
Cdd:cd15976  296 F 296
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
27-246 7.98e-14

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 70.38  E-value: 7.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15297   58 TLYTVIGyWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAIL 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYrQSQLANLTV----CHPAWSAprRRAMDICTFVFSYLLPVLVLGLTYartlrylWRAvdpvaagSGARRAKRKVTRMI 181
Cdd:cd15297  138 FW-QFIVGGRTVpegeCYIQFFS--NAAVTFGTAIAAFYLPVIIMTVLY-------WQI-------SRASSREKKVTRTI 200
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 182 LIVAALFCLCWMPHHALILCVWFGQFPLTRATYalrILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15297  201 LAILLAFIITWTPYNVMVLINTFCASCIPNTVW---TIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
32-246 8.58e-14

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 70.27  E-value: 8.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL---SYYR 108
Cdd:cd15400   64 NGWALGEMHCKVSGFVMGLSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFfvgSLEY 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVCHPAWSaprrrAMDICTFVFSYLLPVLVLGLTYARtlryLWRAVDPVaagsgARRAKRKV-TRM------- 180
Cdd:cd15400  144 DPRIYSCTFVQTASS-----SYTIAVVVIHFIVPITVVSFCYLR----IWVLVIQV-----RRKVKSESkPRLkpsdfrn 209
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 181 ---ILIVAALFCLCWMPHHALILCVWFG-QFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15400  210 fltMFVVFVIFAICWAPLNLIGLAVAINpQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
33-246 8.98e-14

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 70.57  E-value: 8.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFlifltmhASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQL 112
Cdd:cd15358   73 GCYFKTLLFETVCF-------ASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQL 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 -----------ANLTVCHPAWSapRRRAMDICTFVFsYLLPV-------LVLGLTYARtlRYLWRAVDPVAAGSG----- 169
Cdd:cd15358  146 tvpcrgpvpdsATCMLVKPRWM--YNLIIQITTLLF-FFLPMgtisvlyLLIGLQLKR--EKMLLVLEAKGSKAGdsyqh 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 170 -----ARRAKRKVTRMILIVAALFCLCWMPHHA-----LILCVWFGqfPLTRATYALRILSHLVSYANSCVNPIVYALVS 239
Cdd:cd15358  221 rriqqEKRRRRQVTKMLFVLVVVFGICWAPFHTdrlmwSFISQWTG--ELHLAFQYVHIISGVFFYLSSAANPVLYNLMS 298

                 ....*..
gi 767996348 240 KHFRKGF 246
Cdd:cd15358  299 TRFREMF 305
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
36-244 9.58e-14

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 70.18  E-value: 9.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  36 FGSLLCKAVHFL-IFLTMHASsFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP--YLSYYRQSQL 112
Cdd:cd15219   68 FGDGFCQAVGFLeTFLTSNAM-LSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLValFLSWLGYSSL 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 -ANLTVCHPAWSAPRRRAMDICTF-VFSYLLPVLVLGLTYARTLRYlwravdpvaagsgarRAKRKVTRMILIVAALFCL 190
Cdd:cd15219  147 yASCTLHLPREEERRRFAVFTAFFhAFTFLLSLLVLCVTYLKVLKV---------------RRRQRATKKISIFIGTFVL 211
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767996348 191 CWMPHHALILCVwfgQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15219  212 CFAPYVITRLVE---LLPFVTINRYWGIVSKCLTYSKAASDPFVYSLLRQQYRK 262
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
25-246 1.04e-13

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 70.00  E-value: 1.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDG--WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTP---RNALAAIGLIWGLSLLF 99
Cdd:cd15310   56 WVVYLEVTGgvWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQsscRRVSLMITAVWVLAFAV 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 100 SGPYLSYYRQSqlANLTVChpAWSAPrrrAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagsgarraKRKVTR 179
Cdd:cd15310  136 SCPLLFGFNTT--GDPTVC--SISNP---DFVIYSSVVSFYLPFGVTLLVYVRIYVVLLR--------------EKKATQ 194
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 180 MILIVAALFCLCWMPHhaLILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15310  195 MLAIVLGAFIVCWLPF--FLTHILNTHCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
26-246 1.21e-13

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 70.32  E-value: 1.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSG-PYL 104
Cdd:cd15958   58 ATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFlPIM 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYRQSQLANLTVChpaWSAPR------RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSG--------- 169
Cdd:cd15958  138 MHWWRDEDDQALKC---YEDPGccdfvtNRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQIKKIDKCEGrfhntltgl 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 170 ARRAKRKVTRMIL-----------IVAALFCLCWMPHH-ALILCVWFGQFPLTRATYALRILshlvSYANSCVNPIVYAL 237
Cdd:cd15958  215 GRKCKRRPSRILAlreqkalktlgIIMGVFTLCWLPFFlVNVVNVFNRELVPDWLFVFFNWL----GYANSAFNPIIYCR 290

                 ....*....
gi 767996348 238 vSKHFRKGF 246
Cdd:cd15958  291 -SPDFRKAF 298
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
36-249 1.24e-13

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 69.98  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  36 FGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANL 115
Cdd:cd15307   68 LSSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVL 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 116 T--VCHPAWSAPRRRAMDICtfvfsYLLPVLVLGLTYARTLRYLWRAvdpVAAGSGARRAKRKVTRMILIVAALFCLCWM 193
Cdd:cd15307  148 VngTCQIPDPVYKLVGSIVC-----FYIPLGVMLLTYCLTVRLLARQ---RSRHGRIIRLEQKATKVLGVVFFTFVILWS 219
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 194 PHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTI 249
Cdd:cd15307  220 PFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKV 275
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
27-243 1.34e-13

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 69.70  E-value: 1.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDgWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIrypLHSRELRTPRNALAAIGLIWGLSLLFSGP---- 102
Cdd:cd15213   60 TIITGR-WIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPplvg 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 ---YLSYYRQSQlanLTVCHPawSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwravdpvaagsgaRRAKRKVTR 179
Cdd:cd15213  136 wgkYEFPPRAPQ---CVLGYT--ESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTV-------------RSFKTRAFT 197
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 180 MILIVAALFCLCWMPHHALILCVWFGQFplTRATYALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15213  198 TILILFIGFSVCWLPYTVYSLLSVFSRY--SSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
28-240 1.50e-13

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 69.82  E-value: 1.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTLDG--WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15371   57 VYHLNGnnWVFGETMCRIITITFYGNMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFI 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQL--ANLTVCHPAWSAPRRRA-----MDICTFVFSYLLPVLVLGLTYARTLRYLwravdpvaagsGARRAKR--- 175
Cdd:cd15371  137 LKQTYYLkeLNITTCHDVLPECEQNSnfqfyYFISMAVFGFLIPLVITIFCYISIIRTL-----------NAYEHKWfwy 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 176 -KVTRMILIVaalFCLCWMPHHALILCVWFGQFPL-TRATYALRILSHLVSYANSCVNPIVYALVSK 240
Cdd:cd15371  206 vKITALVLII---FTICFAPSNVILIIHHFNYYYFnNDNLYSIYLIALCLGSLNSCLDPFLYFLMSK 269
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
34-244 1.52e-13

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 69.69  E-value: 1.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15159   66 WPFGDWLCRLTALLFYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMG 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVC--HPAWSA-PRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAV--DPVAAGSGARRAKRKVTRMILIVaalF 188
Cdd:cd15159  146 GRITCmeYPNFEKiKRLPLILLGACVIGFGVPVGIILFCYSQITLKLCRTAkeNPLTEKSGHHKKACNVILLVLLV---F 222
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 189 CLCWMPHHALILcvwfgQFPLTRATY--------ALRILSHL-VSY--ANSCVNPIVYALVSKHFRK 244
Cdd:cd15159  223 VVCFSPYHLNII-----QFMIRKLLYqpscselkAFKISLQItVCLmnLNCCLDPFIYFFACKGYKK 284
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
27-246 1.64e-13

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 69.38  E-value: 1.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15050   58 IVYLLESkWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILG 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHPAWSAPRRRA--MDICTFVFSYLLPVLVLGLTYARTLRylwravdpvaagsgARRAKRKVTRMILI 183
Cdd:cd15050  138 WHHFARGGERVVLEDKCETDFHDVtwFKVLTAILNFYIPSLLMLWFYAKIFK--------------AVNRERKAAKQLGF 203
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 184 VAALFCLCWMPHHALILCVWFGQfplTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15050  204 IMAAFILCWIPYFILFMVIAFCK---NCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
46-246 1.77e-13

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 69.58  E-value: 1.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  46 FLIFLTmHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYLSYYRQSQLANLTVCHPAWSA 124
Cdd:cd15069   77 FVLVLT-QSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGlTPFLGWNKAMSATNNSTNPADHGT 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 125 PRRRAMDICTF----VFSY----------LLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRK---VTRMILIVAAL 187
Cdd:cd15069  156 NHSCCLISCLFenvvPMSYmvyfnffgcvLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQReihAAKSLAIIVGI 235
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 188 FCLCWMPHHALILCVWFG-QFPLTRATYALRIlSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15069  236 FALCWLPVHILNCITLFQpEFSKSKPKWAMNV-AILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
32-243 1.92e-13

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 69.44  E-value: 1.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLF-SGPYLSYYRQS 110
Cdd:cd15366   64 DNWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGAnSAPLFHDELFR 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTVCHPAWSAPRRRA-MDICTFVFSYLLPVLVLGLTYARTLRYLWRAVdpvaagSGARRAKRKVTRMILIVAALFC 189
Cdd:cd15366  144 DRYNHTFCFEKYPMEDWVAwMNLYRVFVGFLFPWVLMLFSYRGILRAVRGNV------STEQQEKAKIKRLALSLIAIVL 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 190 LCWMPHHALIL---CVWFGQ----------FPLTRATYALRILshlvsyaNSCVNPIVYALVSKHFR 243
Cdd:cd15366  218 LCFAPYHVLLLsrsVVYLGKpcdcgfeervFTAYHVSLALTSL-------NCVADPILYCLVNEGAR 277
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
32-244 1.95e-13

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 69.34  E-value: 1.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSyyRQSQ 111
Cdd:cd15148   64 NQWTLGPLLCKVVGNLFYMNMYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIV--LTEK 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVC-------HPAWSAprrramdictfVFSYLLPV------LVLGLTYARTLRYLWRA----VDPVAAGSGARRAK 174
Cdd:cd15148  142 NEESTKCfqykdrkNAKGKA-----------IFNFLIVAmfwlvfLLLILSYGKIAKKLLRIsrdkPDFPNAAKYNRTAR 210
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 175 RKvtrmiLIVAALFCLCWMPHHALILCVWFGQFPLTrATYALRILSH------LVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15148  211 KS-----FFVLFIFTVCFVPYHAFRIFYITSQLQNN-SCYWKEILHKtneimlLLSAFNSCLDPVMYFLLSSSIRK 280
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
34-246 2.02e-13

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 69.69  E-value: 2.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLL--FSGPYLSYYRQSQ 111
Cdd:cd15065   65 WLFGETFCNIWISFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALisFLPIHLGWHRLSQ 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAwSAPRRRAMD------ICTFVFSYLLPVLVLGLTYARTLRY---------------LWRAVDPVAAGSGA 170
Cdd:cd15065  145 DEIKGLNHAS-NPKPSCALDlnptyaVVSSLISFYIPCLVMLLIYSRLYLYarkhvvniksqklpsESGSKFQVPSLSSK 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 171 RRAKR----KVTRMILIVAALFCLCWMPHHAL-ILCVWFGQ-FPLTratyALRILSHLvSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15065  224 HNNQGvsdhKAAVTLGIIMGVFLICWLPFFIInIIAAFCKTcIPPK----CFKILTWL-GYFNSCLNPIIYSIFNSEFRR 298

                 ..
gi 767996348 245 GF 246
Cdd:cd15065  299 AF 300
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
34-252 2.04e-13

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 69.51  E-value: 2.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTpRNALAAIGLIWGLSLLFSGPYL---SYYRQS 110
Cdd:cd15084   76 FVFGKTMCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQ-RHAVSGCAFTWGWSLLWTSPPLfgwSSYVPE 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLAnlTVCHPAW--SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALF 188
Cdd:cd15084  155 GLR--TSCGPNWytGGTNNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESETTQRAEKEVTRMVIAMVMAF 232
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 189 CLCWMPHHALILCVWFGQFPLTRATYAlrILSHLVSYANSCVNPIVYALVSKHFRKGF-RTICAG 252
Cdd:cd15084  233 LICWLPYATFAMVVATNKDVVIQPTLA--SLPSYFSKTATVYNPIIYVFMNKQFRSCLlELLCCG 295
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
26-246 2.11e-13

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 69.55  E-value: 2.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYL 104
Cdd:cd15959   58 ATILLTGHWPLGTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISfLPIM 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 S-YYRQSQLANLTVCHpawSAPRrramdICTFV-----------FSYLLPVLVLGLTYARTLRYLWRAVD---------- 162
Cdd:cd15959  138 NqWWRDGADEEAQRCY---DNPR-----CCDFVtnmpyaivsstVSFYVPLLVMIFVYVRVFVVATRQVRlirkdkvrfp 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 163 ----PVAAGSGARRAK---------RKVTRMILIVAALFCLCWMPHH-ALILCVWFGQFPLTRATYALRILshlvSYANS 228
Cdd:cd15959  210 peesPPAESRPACGRRpsrllaikeHKALKTLGIIMGTFTLCWLPFFvANIIKVFCRSLVPDPAFLFLNWL----GYANS 285
                        250
                 ....*....|....*...
gi 767996348 229 CVNPIVYALvSKHFRKGF 246
Cdd:cd15959  286 AFNPIIYCR-SPDFRSAF 302
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
38-246 2.49e-13

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 69.19  E-value: 2.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  38 SLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELrTPRNALAAIGLIWGLSLLFSG-PYLSYYRQSQLANL- 115
Cdd:cd14980   78 SPPCLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFSIIFAAiPILYSINQPGDNRLy 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 116 ---TVCHPawsaprrraMDIC-TFVFSYLLPVLVLGL--------TYARTLRYLWRAVDPVAAgSGARRAKRKVTRMILI 183
Cdd:cd14980  157 gysSICMP---------SNVSnPYYRGWLIAYLLLTFiawiiiciLYILIFISVRKSRKSARR-SSSKRDKRIAIRLALI 226
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 184 VAAlFCLCWMPHHALILCVWFGQFPLTraTYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14980  227 LIT-DLICWLPYYIVIFSGLLTSTEID--IHVLQFIAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
34-246 3.27e-13

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 68.56  E-value: 3.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS--GPYLSYYRQSQ 111
Cdd:cd15066   65 WMFGYFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISflPIFLGWYTTEE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPawsaprrramDICTFV-----------FSYLLPVLVLGLTYARTLRYlwravdpvaagsgARRaKRKVTRM 180
Cdd:cd15066  145 HLQYRKTHP----------DQCEFVvnkiyalisssVSFWIPCIVMIFTYYRIYLE-------------AKR-EHKAAKT 200
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 181 ILIVAALFCLCWMPhhaliLCVWFGQFPLTR-ATYALRILSHL---VSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15066  201 LGIIMGAFILCWLP-----FFLWYVTTTLCGdACPYPPILVSIlfwIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
34-246 4.02e-13

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 68.61  E-value: 4.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSReLRTPRNALAAIGLIWGLSLLFS-GPYLSYYRQSQL 112
Cdd:cd15086   66 WLIGEHGCRWYGFANSLFGIVSLISLAVLSYERYCTLLRPTEAD-VSDYRKAWLGVGGSWLYSLLWTlPPLLGWSSYGPE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWSA--PRRRAMDICTFVFSYLLPVLVLGLTYARTLrYLWRAVDPVAAgSGARRAKRKVTRMILIVAALFCL 190
Cdd:cd15086  145 GPGTTCSVQWTSrsANSISYIICLFIFCLLLPFLVMVYCYGRLL-YAIKQVGKINK-STARKREQHVLLMVVTMVICYLL 222
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 191 CWMPHHALILCVWFGqfPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15086  223 CWLPYGVMALLATFG--KPGLVTPVASIVPSILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
41-243 6.43e-13

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 67.88  E-value: 6.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYLSYYRQSQLANLTV-- 117
Cdd:cd15070   71 CLFMSCLLVVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGlTPMFGWNRKPSLESVNTtp 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 118 --CHPAwSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRA----KRKVTRMILIVAALFCLC 191
Cdd:cd15070  151 lqCQFT-SVMRMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGFRETGAfygrEFKTAKSLALVLFLFAVC 229
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767996348 192 WMPHHaLILCVWFGQFPLTRATYALRIlshLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15070  230 WLPLS-IINCVVYFNPKVPKIALYLGI---LLSHANSMMNPIVYACKIKKFK 277
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
32-246 7.13e-13

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 67.87  E-value: 7.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQ 111
Cdd:cd15367   64 DNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEISK 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LA-NLTVCHPAWS-APRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVdpvaagsGARRAKR-KVTRMILIVAALF 188
Cdd:cd15367  144 DKeNHSVCFEHYPiKAWEHNINYYRFYAGFLFPIFLLSFSYCRILRAVRKSH-------GTQKSQKiQIKRLVLSTVVIF 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 189 CLCWMPHHALIL--CVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15367  217 LVCFGPYHILLLvrSVFERDCNFAEGIFNYYHFSLLLTSFNCVADPVLYCFASESTYHDF 276
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
34-246 7.44e-13

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 67.64  E-value: 7.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQla 113
Cdd:cd15321   72 WYFRKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQK-- 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTlrYLWravdpvaagsgARRAKRKVTRMILIVAALFCLCWM 193
Cdd:cd15321  150 DEQGGLPQCKLNEEAWYILSSSIGSFFAPCLIMILVYLRI--YLI-----------AKNREKRFTFVLAVVIGVFVLCWF 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 194 PhhalilcvWFGQFPLTRATYALRILSH-------LVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15321  217 P--------FFFSYSLGAICPELCKVPHslfqfffWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
25-243 9.70e-13

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 67.46  E-value: 9.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATiYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAI-RYPLHSrelRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd15176   56 WAA-DAVNGWVLGTAMCKITSALYTMNFSCGMQFLACISVDRYVAItKATSRQ---FTGKHCWIVCLCVWLLAILLSIPD 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQSQLANLTVCHPAWSAPRRRAM----DICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgARRAKRKVTR 179
Cdd:cd15176  132 LVFSTVRENSDRYRCLPVFPPSLVTSAkatiQILEVLLGFVLPFLVMVFCYSRVARALSRT---------PNVKKSRALK 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 180 MILIVAALFCLCWMPHHALILCVWFGQFPL--------TRATYALRILSHLVSYaNSCVNPIVYALVSKHFR 243
Cdd:cd15176  203 VLLAVVGVFIVTQLPYNVVKFYRAIDVIYLlitdcsmsKTLDIAIQVTESIALF-HSCLNPVLYVFMGASFK 273
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
25-244 9.94e-13

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 67.47  E-value: 9.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd15147   58 WIVYYHNEGnWILPKFLCNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYF 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 L----SYYRQSQLANLTVCHPAWSAPRRRAMDICTFV-----FSYLLPVLVLGLTYARTLRYlwravDPVaAGSGARRAK 174
Cdd:cd15147  138 LfmdsTNTVKIDSGNFTRCFEGYEKDNSKPVLIIHFIiiglfFLVFLLILVCNLVIARTLLS-----QPV-QGQRNAGVK 211
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 175 RKVTRMILIVAALFCLCWMPHHAL-------ILCVWFGQFPLTRATY--ALRILSHLVSyANSCVNPIVYALVSKHFRK 244
Cdd:cd15147  212 RRALWMVCTVLAVFVICFVPHHVVqgpwtlaVLQQWRYWDCQFRQALndAHQITLCLMS-TNCVLDPVIYCFLTKKFRK 289
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
34-243 1.02e-12

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 67.16  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPrNALAAIGLIWGLSLLFSGPYL---SYYRQS 110
Cdd:cd15077   66 FVLGPLACKIEGFTATLGGMVSLWSLAVVAFERFLVICKPLGNFTFRGT-HAIIGCIATWVFGLAASLPPLfgwSRYIPE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLAnlTVCHPAWSAPRRR----AMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAA 186
Cdd:cd15077  145 GLQ--CSCGPDWYTTNNKwnneSYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKQQEQSASTQKAEREVTKMVVVMVL 222
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 187 LFCLCWMPHHALILCVWFGQfpltRATYALRILS--HLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15077  223 GFLVCWLPYASFALWVVTNR----GEPFDLRLASipSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
27-246 1.04e-12

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 66.97  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15298   58 TVYIIKGyWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAIL 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYrQSQLANLTV----CHPAW-SAPrrrAMDICTFVFSYLLPVLVLGLTYARTlrylwravdpvaagSGARRAKRKVTRM 180
Cdd:cd15298  138 FW-QFVVGKRTVpdnqCFIQFlSNP---AVTFGTAIAAFYLPVVIMTVLYIHI--------------SLASARERKVTRT 199
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 181 ILIVAALFCLCWMPHHALILCVWFGQFPLTRATYAlriLSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15298  200 IFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWS---IGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
34-246 1.31e-12

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 67.07  E-value: 1.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRelRTPRNALAAIGLIWGLSLLFSGPYLSY--YRQSQ 111
Cdd:cd15000   65 YVLGSVGCKLEGFLEGSLLLASVLALCAVSYDRLTAIVLPSEAR--LTKRGAKIVIVITWIVGLLLALPLAIYrsYRERQ 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLtvcHPAWSAPRRRAMDICTFVFSYLL---PVLVLGLTYARTLRYLWRAVDPVAAGSGAR--RAKRKVTRMILIVAA 186
Cdd:cd15000  143 WKNF---LETYCAENTQVLPIYWHVIITVLvwlPLGIMLICYSAIFWKLDKYERRVLRREHPSvvRYKKKAAKTLFIVLI 219
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 187 LFCLCWMPHHALIlcVWFGQFPLTRATY--------ALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15000  220 TFVVCRIPFTALI--FYRYKLVPNDNTQnsvsgsfhILWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
25-246 2.26e-12

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 66.57  E-value: 2.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDG-WVFGSLLCKAVHFLIFLTMhASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS--G 101
Cdd:cd15320   58 WKAVAEIAGfWPFGSFCNIWVAFDIMCST-ASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfiP 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 102 PYLSYYRQSQLANLTVChpawSAPRRRAMDIC-----------TFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAA---- 166
Cdd:cd15320  137 VQLNWHKAKPTSFLDLN----ASLRDLTMDNCdsslnrtyaisSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISAlera 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 167 ---------GSGARRA--------------KR--KVTRMILIVAALFCLCWMPHHALILCVWF------GQFPLTRATYA 215
Cdd:cd15320  213 avhakncqnSTGNRGSgdcqqpessfkmsfKRetKVLKTLSVIMGVFVCCWLPFFILNCMVPFckptstEPFCISSTTFD 292
                        250       260       270
                 ....*....|....*....|....*....|.
gi 767996348 216 LRILshlVSYANSCVNPIVYALvSKHFRKGF 246
Cdd:cd15320  293 VFVW---FGWANSSLNPIIYAF-NADFRKAF 319
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
29-246 2.38e-12

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 66.33  E-value: 2.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR 108
Cdd:cd15154   60 YANHYWPFGNFLCQFSGSIFQMNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHS 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQ--LANLTV--CHPAWSAPRRR---AMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPvaagSGARRakRKVTRMI 181
Cdd:cd15154  140 SSDclLHGEKVyrCFESFSDNDWKgllPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEP----QQGRR--RKTVRLL 213
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 182 LIVAALFCLCWMPHHALILCVWFGQFPLTRATYALR-------ILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15154  214 LVNLVIFLICFVPYNTTLAVYGLLRANLVEDTWNIKdtlrkvlSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
34-246 4.57e-12

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 65.46  E-value: 4.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15201   66 WKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYLLTKKHLFPRG 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVC-------HPAWSAPRRRAMdictFVFSYLLPV-LVLGLTYARTLRYLWRAVDpvaagsgaRRAK-RKVTRMILIV 184
Cdd:cd15201  146 NATQCesfnictGTDSSSNWHEAM----FLLEFFLPLaIILYCSVRIIWQLRGRQLD--------RHAKiKRAVQFIMVV 213
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 185 AALFCLCWMPH-----HALILCVWFGQF--PLTRATYALRIlSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15201  214 AIVFIICFLPSnvtriAIWILKHTSNEDcqYYRSVDLAFYI-TISFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
31-239 4.94e-12

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 65.18  E-value: 4.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLhSRELrTPRNALAAIGLIWGLSLLFSGPYLSYYR-- 108
Cdd:cd15398   63 LDQWIFGEVMCHIVPFLQCVSVMVSTLMLMSIAIVRYHMIKHPL-SNHL-TANHGYFLLGTVWTLGFTICSPLPVFHKiv 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 -------QSQLANLTVCHPAW-SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAvdpvaagsgarrakRKVTRM 180
Cdd:cd15398  141 dlsetfnLESLKNKYLCIESWpSDSYRIAFTISLLFVQYILPLVCLTVSHTSVCRSVKRS--------------RSVFYR 206
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 181 ILIVAALFCLCWMPHHALILCVWFGQFPLTRATYAL-RILSHLVSYANSCVNPIVYALVS 239
Cdd:cd15398  207 LTIVILAFAVSWMPLHLFHLVTDFNANLISNRHFKLvYCICHLLGMLSCCLNPILYGFLN 266
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
25-244 5.15e-12

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 65.17  E-value: 5.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATiYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAI--GLIWGLSLLFSGP 102
Cdd:cd15175   56 WAA-SAAKKWVFGEEMCKAVYCLYKMSFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAVFISKVssLGVWVLAFILSIP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLSYYRQSQLANLTVCHPAWSAPR--RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDpvaagsgarRAKRKVTRM 180
Cdd:cd15175  135 ELLYSGVNNNDGNGTCSIFTNNKQtlSVKIQISQMVLGFLVPLVVMSFCYSVIIKTLLQARN---------FEKNKAIKV 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 181 ILIVAALFCLCWMPHHALILCVWFGQFPLTRAT--------YALRIlSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15175  206 IIAVVVVFVVFQLPYNSVMLVSTLSSFKGNTTDcdysknldFALDV-TYSLACFRCCLNPFLYAFIGVKFRN 276
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
34-243 5.16e-12

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 65.22  E-value: 5.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTpRNALAAIGLIWGLSLLFS-GPYLSYYRQSQL 112
Cdd:cd15076   66 FFFGRTVCALEAFVGSLAGLVTGWSLAFLAFERYIVICKPFGNFRFGS-KHALGAVVATWIIGIGVSlPPFFGWSRYIPE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAW----SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGA-RRAKRKVTRMILIVAAL 187
Cdd:cd15076  145 GLQCSCGPDWytvgTKYRSEYYTWFLFIFCFIVPLSIIIFSYSQLLGAL-RAVAAQQQESAStQKAEREVSRMVVVMVGS 223
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 188 FCLCWMPHHAliLCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15076  224 FCLCYVPYAA--LAMYMVNNRDHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFR 277
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
34-242 5.68e-12

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 65.10  E-value: 5.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSqlA 113
Cdd:cd15967   66 WIFGQVFCKITRFCFNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTN--S 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWS---APRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWR--AVDPVaagsgarrAKRKVTRMILIVAALF 188
Cdd:cd15967  144 NGTKCFDTTFndyLESYLTYSLGWTVTGFVIPLLIILGCYGHVVVVLCRnnNVDKG--------LKQRCLKLVIILIVLF 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 189 CLCWMPHHAL--------IL-----CVWFgqfplTRATYALRILSHLVSYANSCVNPIVYALVSKHF 242
Cdd:cd15967  216 SVCYIPYHVFrnlnllsrILqkqgsCTQW-----FRGIYIAHQVSRGLVCLNSALNPLVYLMGSEDI 277
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
34-246 5.96e-12

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 65.18  E-value: 5.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd14988   66 WLWGSFLCKFTHYFYFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLDGV 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NlTVC--------HPAWSAprrrAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPvaagsgarrAKRKVTRMILIVA 185
Cdd:cd14988  146 E-PMClflapfetYDEWAL----AVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRP---------ESRRHCLLIYAYI 211
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 186 ALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHL------VSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd14988  212 LVFVVCWLPYHVTLLLLTLHGSHISLHCNLVHFLYFFydvidcFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
34-246 7.94e-12

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 64.51  E-value: 7.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15324   66 WYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDEWE 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLtVCHPAWSAprrramdICTFVFSYLLPVLVLGLTYARTLRYlwravdpvaagsgARRAKRKVTRMILIVAALFCLCWM 193
Cdd:cd15324  146 CL-LNDETWYI-------LSSCTVSFFAPGLIMILVYCKIYRV-------------AKMREKRFTFVLAVVMGVFVLCWF 204
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 194 PhhalilcvWFGQFPLTRATY-------ALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15324  205 P--------FFFTYSLHAVCRkrcgipdALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-241 8.06e-12

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 64.84  E-value: 8.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  39 LLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRnalAAIGLIWGLSLLFSGPYLSYYRQSQLAN-LTV 117
Cdd:cd15387   71 FLCRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDR---VYVLFSWLLSLVFSIPQVHIFSLREVGNgVYD 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 118 CHPAWSAPRRRAMDICTFVFS-YLLPVLVLGLTYARTLRYLWRAVD---------PVAAGSGAR-------------RAK 174
Cdd:cd15387  148 CWADFIQPWGPKAYITWITLSvYIIPVLILSVCYGLISFKIWQNVKlktrretktPLSSAASGGaalarvssvklisKAK 227
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 175 RKVTRMILIVAALFCLCWMPHHAL-ILCVWFGQFPLTRATYalrILSHLVSYANSCVNPIVYALVSKH 241
Cdd:cd15387  228 IRTVKMTFVIVLAYIVCWTPFFFVqMWSVWDPNAPKEASPF---IIAMLLASLNSCCNPWIYMFFTGH 292
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
26-246 8.19e-12

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 64.88  E-value: 8.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLL--FSGPY 103
Cdd:cd15957   58 AAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLtsFLPIQ 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQSQ------LANLTVCHPAWSAprrrAMDICTFVFSYLLPVLVLGLTYARTL---------------RYLWRAVD 162
Cdd:cd15957  138 MHWYRATHqeaincYAEETCCDFFTNQ----AYAIASSIVSFYVPLVIMVFVYSRVFqeakrqlqkidksegRFHNQNID 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 163 PVAAGSGARRAKR--------KVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYalrILSHLVSYANSCVNPIV 234
Cdd:cd15957  214 QNGSGGGGGNRRRskfclkehKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVY---ILLNWIGYVNSGFNPLI 290
                        250
                 ....*....|..
gi 767996348 235 YALvSKHFRKGF 246
Cdd:cd15957  291 YCR-SPDFRIAF 301
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
23-246 9.21e-12

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 64.57  E-value: 9.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  23 VQWATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP 102
Cdd:cd15304   56 VSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMP 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 --YLSYYRQSQLANLTVChpawSAPRRRAMDICTFVfSYLLPVLVLGLTYARTLRYLWRAVDpvaagsgarrAKRKVTRM 180
Cdd:cd15304  136 ipVFGLQDDSKVFKEGSC----LLADENFVLIGSFV-AFFIPLTIMVITYFLTIKSLQQSIS----------NEQKASKV 200
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 181 ILIVAALFCLCWMPHHAL-ILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15304  201 LGIVFFLFVVMWCPFFITnVMAVICKESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
25-257 9.69e-12

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 64.20  E-value: 9.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd14973   55 QSLEDLLGGSLPGFALCRLLATLMFFSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLES 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYyrqsqlanltvCHPAWSAPRRRAMDICTFVF--SYLLPVLVLGLTYARTL-RYLWRAvdpvaagsgARRAKRKVTRMI 181
Cdd:cd14973  135 YF-----------CGFLFWKFNESACRTFNFLSalLFLLLFLVMCVSSLTLLiRVQCSS---------QRRPPTRLYVVI 194
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 182 LIVAALFCLCWMPHHALILCV-WFGQFPLTRATYalriLSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRA 257
Cdd:cd14973  195 LLTVLVFLLCGLPLGIYWFLLlWFSNYLFHTFHP----ISDLLSCVNSSANPIIYFFVGSLRGRRLREPLRVVLQRA 267
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
29-243 9.77e-12

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 64.46  E-value: 9.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYR 108
Cdd:cd15166   60 YAKDEWPFGDYFCRILGALTVFYPSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYE 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 Q-SQLANLTVCHPAWSAPRRRAMDICTFV---FSYLLPVLVLGLTYARTLRYLWRAvdpvAAGSGARRAKRKVTRMILIV 184
Cdd:cd15166  140 DpDKASNFTTCLKMLDIIHLKEVNVLNFTrliFFFLIPLFIMIGCYLVIIHNLVHG----RTSKLKPKVKEKSIRIIITL 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 185 AALFCLCWMPHHaliLCVWFGQFPLTRATYA-LRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15166  216 IVQVLVCFVPFH---ICFAFLMLQNGDNSYNpWAAFTTFLMNLSTCLDVILYYIVSKQFQ 272
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
27-246 1.26e-11

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 63.99  E-value: 1.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDG--WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGL-SLLFS--- 100
Cdd:cd15302   58 TVYVLNGdyWPLGWVLCDLWLSVDYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIpALLFFisi 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 101 --GPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFvFSYLLPVLVLgltYARTLRylwravdpvaagsGARRAkRKVT 178
Cdd:cd15302  138 fgWQYFTGQGRSLPEGECYVQFMTDPYFNMGMYIGYY-WTTLIVMLIL---YAGIYR-------------AANRA-RKAL 199
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 179 RMILIVAALFCLCWMPHHALILCVWFGQFPlTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15302  200 RTITFILGAFVICWTPYHILATIYGFCEAP-PCVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
27-237 1.46e-11

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 64.02  E-value: 1.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRtpRNALAAIGLIWGLSLLFSGPYL-- 104
Cdd:cd15212   60 TLFSRPGWLFGDRLCLANGFFNACFGIVSTLTMTLISFDRYYAIVRQPQGKIGR--RRALQLLAAAWLTALGFSLPWYll 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 -----SYYRQSQLANLTVCHPAwSAPRRRAMDICTFVFSYLLPVLVLGLTY---ARTLRYLWRAVDPVAAGSGARR--AK 174
Cdd:cd15212  138 asapeYYEKLGFYHCLYVLHSG-PSRLGAAYSSVLIVLCYLLPFALMCFCHyniCKTVRLSESRVRPVTTYAHLLRfySE 216
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 175 RKVTRMILIVAALFCLCWMPHHALILCVWFG--QFPLTRATYALRILshlvsYANSCVNPIVYAL 237
Cdd:cd15212  217 MRTATTVLIMIVFIICCWGPYCLLGLVAAAGgyQFPPLMDTVAIWMA-----WANGAINPLIYAI 276
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
34-246 1.83e-11

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 63.42  E-value: 1.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL-SYYRQSQL 112
Cdd:cd15322   66 WYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLiTIEKKSGQ 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVChpawSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYlwravdpvaagsgARRAKRKVTRMILIVAALFCLCW 192
Cdd:cd15322  146 PEGPIC----KINDEKWYIISSCIGSFFAPCLIMVLVYIRIYQI-------------AKNREKRFTFVLAVVIGVFVICW 208
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767996348 193 MPhhaLILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15322  209 FP---FFFTYTLTAVCDCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
34-246 2.56e-11

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 63.19  E-value: 2.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYpLHSRELRTPRNALAAIGL-IWGLSLLFSGPYLSYYRQSQL 112
Cdd:cd15922   66 WPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVH-YNWKSLWKKKSFMKKLCLgVWLLLFVQGLPFFFVLKTSVI 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVC---HPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVdpvAAGSGARRAKRKVTRMILIVAALFC 189
Cdd:cd15922  145 DGKTKClsiHQSELSLLYFVWNFVLLILGFLLPFGVSLTCYALLGASIAKMN---SNNARGRAMKAKSLQMIGISLVIFI 221
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 190 LCWMPHH-ALILCVWFGQF-----PLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15922  222 ICFVPLHvTRTVGVVVKLFypescTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
34-246 4.07e-11

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 62.62  E-value: 4.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSG--PYLSYYRQSQ 111
Cdd:cd15305   67 WPLPRYLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMpiPVIGLQDDEK 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVChpawSAPRRRAMDICTFVfSYLLPVLVLGLTYARTLRYLWRavdpvaagSGARRAKRKVTRMILIVAALFCLC 191
Cdd:cd15305  147 VFVNGTC----VLNDENFVLIGSFV-AFFIPLIIMVITYCLTIQVLQR--------QQAINNERRASKVLGIVFFLFLIM 213
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 192 WMPHHAL-ILCVwfgqfpLTRATYALRILSHL------VSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15305  214 WCPFFITnILSV------LCKEACDQKLMEELlnvfvwVGYVSSGINPLVYTLFNKTYRRAF 269
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
41-246 6.29e-11

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 62.17  E-value: 6.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIW------GLSLLFSGPYLSYYRQSQLAN 114
Cdd:cd15071   71 CLMVACPVLILTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWilsflvGLTPMFGWNNLNAVERAWAAN 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 115 LTVCHPAWSAPRRRAMDICTFV----FSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKR------KVTRMILIV 184
Cdd:cd15071  151 SSMGELVIKCQFETVISMEYMVyfnfFVWVLPPLLLMLLIYLEVFYLIRKQLNKKVSSSSSDPQKyygkelKIAKSLALI 230
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 185 AALFCLCWMPHHALILCVWFgqFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15071  231 LFLFALSWLPLHILNCITLF--CPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
25-246 6.79e-11

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 62.28  E-value: 6.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTLDG-WVFGSLLCKAVHFLIFLTMhASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSG-P 102
Cdd:cd15319   57 WKAVAEVAGyWPFGAFCDVWVAFDIMCST-ASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFiP 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLSYYRQSQLANLTVCHPAW---------SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRY----------LWRAVDP 163
Cdd:cd15319  136 VQLNWHKDSGDDWVGLHNSSisrqveencDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIaqiqirrissLERAAEH 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 164 VAAGSGAR-------------RAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLV------- 223
Cdd:cd15319  216 AQSCRSNRidchhhtslrtsiKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRPPADPDAGLPCVSETTfdvfvwf 295
                        250       260
                 ....*....|....*....|...
gi 767996348 224 SYANSCVNPIVYALvSKHFRKGF 246
Cdd:cd15319  296 GWANSSLNPIIYAF-NADFRKVF 317
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
26-246 7.39e-11

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 61.73  E-value: 7.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDG-WVFGSLLCKavhflIFLTMH-----ASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLF 99
Cdd:cd15333   61 SIVYTVTGtWTLGQVVCD-----IWLSSDitcctASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISI 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 100 SGPYLsYYRQSQLAN-LTVC-----HPAWSaprrramdICTFVFSYLLPVLVLGLTYARTLRylwravdpvaagsGARRA 173
Cdd:cd15333  136 SLPPF-FWRQAKAEEeVSECvvntdHILYT--------VYSTVGAFYIPTLLLIALYGRIYV-------------EARAR 193
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 174 KRKVTRMILIVAALFCLCWMPHHALILCVwfgqfPLTRATY----ALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15333  194 ERKATKTLGIILGAFIVCWLPFFIISLVL-----PICKDACwfhlAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
33-244 7.63e-11

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 61.68  E-value: 7.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELrTPRNALAAIGLIWGLSLLFSG-PYLSYYRQSQ 111
Cdd:cd15073   65 SWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTICRPDLGRKM-TTNTYTVMILLAWTNAFFWAAmPLVGWASYAL 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSAPRR--RAMDICTFVFSYLLPVLVLGLTYartlRYLWRAVDPVAAGSGARRA------KRKVTRMILI 183
Cdd:cd15073  144 DPTGATCTINWRKNDSsfVSYTMSVIVVNFIVPLAVMFYCY----YNVSRFVKKVLASDCLESVnidwtdQNDVTKMSVI 219
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 184 VAALFCLCWMPHHalILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15073  220 MIVMFLVAWSPYS--IVCLWASFGEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRR 278
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
34-244 1.68e-10

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 60.89  E-value: 1.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIG--LIWGLS-LLFsgPYLsyyRQS 110
Cdd:cd15152   65 WPFGKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAgwLVVCVGcLPF--PLL---RQS 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 QLANLTVCHPAW-----SAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwRAVDPVAAGSGarrAKRKVTRMILIVA 185
Cdd:cd15152  140 QDTNPTCCFADLplrnvGLTTSVIMLTIAELTGFVTPLLIVLYCSWKTVMSL-REKTPVLQDLG---EKKKALKMILTCA 215
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 186 ALFCLCWMPHHAlilcvwfgQFPLTRATYALRILS----------HLVSYA----NSCVNPIVYALVSKHFRK 244
Cdd:cd15152  216 VVFLICFAPYHI--------SFPLDFLVKSNKIKSctarkvilifHPVALClaslNSCLDPVIYYFTTDEFKR 280
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
34-244 1.86e-10

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 60.72  E-value: 1.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-------GPYLSY 106
Cdd:cd14981   69 WDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAslpllglGSYVLQ 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSqlanltvchpaWSAPRRRAMDICTFVFSYL---LPVLVLGLTY-------ARTLRYLWRAVDPVAAGSGARRAKRK 176
Cdd:cd14981  149 YPGT-----------WCFLDFYSKNTGDAAYAYLysiLGLLILLVTLlcnllviITLLRMRRRKKRHRRSRRSARRQKRN 217
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 177 VTRMILIVAA---LFCLCWMPhhaLILCVWFGQFPLTRATY-----ALRILShlvsyANSCVNPIVYALvskhFRK 244
Cdd:cd14981  218 EIQMVVLLLAitvVFSVCWLP---LMIRVLINATGDSEKNGktdllAVRMAS-----WNQILDPWVYIL----LRK 281
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
37-243 2.16e-10

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 60.19  E-value: 2.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  37 GSLLCKAVH-FLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSyyrqsqlanL 115
Cdd:cd15163   65 NCLTCSFVHiFSYFVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSILT---------T 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 116 TVCHPAWSAPRRRAMDictfVFSYLLPVLVLgltYARTLRYLWRAVDPVAAGSGARRAKRKVtRMILIVAALFCLCWMPH 195
Cdd:cd15163  136 AIKFASCCLSKLFALT----VFEFFLPLLII---TFFTIRIMCALSRPGLMHQSRERRMRAV-QLLITVLIIFMICFTPF 207
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767996348 196 HALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15163  208 HVRQVAVAFNPDIPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
34-246 2.44e-10

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 60.05  E-value: 2.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYP-LHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQL 112
Cdd:cd15309   66 WRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPmLYNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLNNTDQ 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWSaprrramdICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagsgarraKRKVTRMILIVAALFCLCW 192
Cdd:cd15309  146 NECIIANPAFV--------VYSSIVSFYVPFIVTLLVYVQIYIVLQK--------------EKKATQMLAIVLGVFIICW 203
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767996348 193 MPHHALILCVWFGQFPLTRATYALRILshlVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15309  204 LPFFITHILNMHCDCNIPPALYSAFTW---LGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
31-244 2.61e-10

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 60.15  E-value: 2.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYY-RQ 109
Cdd:cd15924   62 LGPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTnQQ 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 SQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPV--LVLGLTYARTLRYLWRAVDPVAAGSGARRakRKVTRMILIVAAL 187
Cdd:cd15924  142 PREKNVKKCSFLKSELGLKWHEIVNYICQVIFWIvfLLMIVCYTAITKKVYRSYRRVFRSSSSRR--KKSNVKIFIIVAV 219
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 188 FCLCWMPHHALILCVWFGQFPLTRATYALRILSH------LVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15924  220 FFVCFVPYHFARIPYTLSQTRDVFDCTAENILFYvkeatlFLSALNVCLDPIIYFFLCKSFRE 282
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
47-246 3.40e-10

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 59.79  E-value: 3.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRnALAAIGLIWGLSLLFSG-PYLSYyrqSQLANLTVCHPAWSAP 125
Cdd:cd15102   78 SMFVALSASVFSLLAIAIERHLTMAKMKPYGASKTSR-VLLLIGACWLISLLLGGlPILGW---NCLGALDACSTVLPLY 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 126 RRRAMDICTFVFSYLLPVLVLglTYARTLRyLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALIL----C 201
Cdd:cd15102  154 SKHYVLFCVTIFAGILAAIVA--LYARIYC-LVRASGRKATRASASPRSLALLKTVLIVLLVFIACWGPLFILLLldvaC 230
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767996348 202 VWFGQFPLTRATYALrilshLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15102  231 PVKTCPILYKADWFL-----ALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
34-246 3.75e-10

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 59.46  E-value: 3.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15308   67 WTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNR 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHpawsaPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagsgarraKRKVTRMILIVAALFCLCWM 193
Cdd:cd15308  147 DPAVCK-----LEDNNYVVYSSVCSFFIPCPVMLVLYCAMFRGLGR--------------ERKAMRVLPVVVGAFLFCWT 207
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 194 PhhalilcvwFGQFPLTRA-TYALRILSHLVS------YANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15308  208 P---------FFVVHITRAlCESCSIPPQLISivtwlgYVNSALNPVIYTVFNAEFRNVF 258
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
29-249 4.80e-10

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 59.45  E-value: 4.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTP-RNALAAIGLIWGLSLLFSGPYLSY 106
Cdd:cd15295   60 YTLTNrWDFGRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVHGPAILV 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSQLANLTvCHPAWSAprRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRavdpvaagsgaRRAKRKVTRMILIVAA 186
Cdd:cd15295  140 SDSWKTEDGE-CEPEFFS--NWYILAITSVLEFLVPVILVAYFNTQIYWSLWK-----------RLRDRKLAKSLAIILG 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 187 LFCLCWMPHhalILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTI 249
Cdd:cd15295  206 TFAICWAPY---SLFTIIRAACEKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKI 265
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
34-246 6.42e-10

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 59.29  E-value: 6.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKaVHFLIFLTMH-ASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYLSYYRQS- 110
Cdd:cd15312   66 WYFGDLFCK-IHSSLDMMLStTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAfGVVFSEVNLEg 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 --QLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTY----------ARTLRYLWRAVDPVAAGSGARRAKRKVT 178
Cdd:cd15312  145 ieDYVALVSCTGSCVLIFNKLWGVIASLIAFFIPGTVMIGIYikiffvarkhAKVINNRPSVTKGDSKNKLSKKKERKAA 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 179 RMILIVAALFCLCWMPHHALILC----------------VWFGqfpltratyalrilshlvsYANSCVNPIVYALVSKHF 242
Cdd:cd15312  225 KTLSIVMGVFLLCWLPFFVATLIdpflnfstpvdlfdalVWLG-------------------YFNSTCNPLIYGFFYPWF 285

                 ....
gi 767996348 243 RKGF 246
Cdd:cd15312  286 QKAF 289
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
34-246 7.29e-10

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 59.00  E-value: 7.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYY----RQ 109
Cdd:cd15317   66 WYFGDLFCKFHTGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGandeGL 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 SQLANLTVC--------HPAWSaprrrAMDICTFvfsyLLPVLVLGLTYARTLRYLWRAVDPVA------------AGSG 169
Cdd:cd15317  146 EEYSSEISCvggcqllfNKIWV-----LLDFLTF----FIPCLIMIGLYAKIFLVARRQARKIQnmedkfrsseenSSKA 216
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 170 ARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFplTRATYALRILSHLvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15317  217 SASRERKAAKTLAIVMGIFLFCWLPYFIDTIVDEYSNF--ITPAIVFDAVIWL-GYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
33-246 2.17e-09

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 57.85  E-value: 2.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYP-LHSRELRTPrNALAAIGLIWGLSLLFSGPYL----SYY 107
Cdd:cd15005   66 GWIYGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHrFYAKRMTFW-TCLAVICMAWTLSVAMAFPPVfdvgTYT 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 RQSQLANLTVCHPAWSAPRrramdicTFVFSYLLPVLVLG--LTYARTLRYLW--RAVDPV------------------- 164
Cdd:cd15005  145 FIREEDQCTFEHRSYKAND-------TLGFMLVLAVVIAAthLVYLKLLIFLRhhRKMKPAqlvpaisqnwtfhgpgatg 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 165 ------------------------AAGSGARR--------AKRKVTRMILIVAALFCLCWMPHhaLILCVWFGQFPLTRA 212
Cdd:cd15005  218 qaaanwtagfgrgptpptllgirqAFHSGARRllvldefkMEKRLTRMFYAITLLFLLLWSPY--IVACYIRVFVRGYAV 295
                        250       260       270
                 ....*....|....*....|....*....|....
gi 767996348 213 TYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15005  296 PQGFLTAAVWMTFAQAGVNPIVCFFFNRELRKCL 329
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
55-243 2.22e-09

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 57.56  E-value: 2.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  55 SSFTLAAVSLDRYLAIRYPLHSRELRTPRnALAAIGLIWGLSLLFS-GPYLSYYRQSQLANLTVCHPAWS--APRRRAMD 131
Cdd:cd15085   87 SLWSLTLLAYERYNVVCKPMGGLKLSTKR-GYQGLLFIWLFCLFWAvAPLFGWSSYGPEGVQTSCSIGWEerSWSNYSYL 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 132 ICTFVFSYLLPVLVLGLTYA---RTLRYLWRAVDPVAAGSGARRAKRKVtRMILIVAALFCLCWMPHHALILCVWFGqfP 208
Cdd:cd15085  166 ILYFLMCFVIPVAIIGFSYGnvlRSLHKLNKKIEQQGGKNCPEEEERAV-IMVLAMVIAFLICWLPYTVFALIVVVN--P 242
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767996348 209 LTRATYALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15085  243 ELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
34-247 2.22e-09

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 57.53  E-value: 2.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15306   67 WPLPLVLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVD 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDpvaagSGARRAkrkvTRMILIVAALFCLCWM 193
Cdd:cd15306  147 NPNNITCVLTKERFGDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQTI-----TNEQRA----SKVLGIVFFLFLLMWC 217
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 194 PHH----ALILCvwfGQFPLTRATYALRILShLVSYANSCVNPIVYALVSKHFRKGFR 247
Cdd:cd15306  218 PFFitniTSVLC---DSCNQTTLQMLMEIFV-WIGYVSSGVNPLVYTLFNKTFRDAFG 271
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
34-247 2.56e-09

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 56.88  E-value: 2.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKavhflIFLTMHASSFT-----LAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLsYYR 108
Cdd:cd15334   66 WIMGQVVCD-----IWLSVDITCCTcsilhLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPL-FWR 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVC-----HPAWSAprrramdICTFVFSYLLPVLVLGLTYArtlryLWRAvdpvaagsgARRAKRKVTRMILI 183
Cdd:cd15334  140 HQTTSREDECiikhdHIVFTI-------YSTFGAFYIPLALILILYYK-----IYRA---------ATRERKAATTLGLI 198
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 184 VAAlFCLCWMPHHALILCVwfgqfPLTRATYALRILSHLVS---YANSCVNPIVYALVSKHFRKGFR 247
Cdd:cd15334  199 LGA-FVICWLPFFVKEVIV-----NTCDSCYISEEMSNFLTwlgYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-246 4.86e-09

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 56.38  E-value: 4.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  50 LTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRqsqlanltvCHPaWSAPrrra 129
Cdd:cd15099   82 MAFTASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMGWR---------CKT-WDSP---- 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 130 mdiCTFVFSY-----------LLPVLVLGLTYARTLrYLWRAVDPVAAGSGARRAKRKVTRM------------ILIVAA 186
Cdd:cd15099  148 ---CSRLFPYidrhylaswtgLQLVLLFLIIYAYPY-ILWKAHRHEANMGGPKLGRQQVKGQarmrmdirlaktLSLILL 223
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 187 LFCLCWMPHHALILCVWFGQfpLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15099  224 VLAICWLPVLAFMLVDVRVT--LTNKQKRMFAFCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
41-244 6.60e-09

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 56.07  E-value: 6.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGpyLSYYRQSQLANLTVCHP 120
Cdd:cd15136   80 CKTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMAL--LPLVGVSSYSKTSICLP 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 121 AWSA-PRRRAMDICTFVFSYLLPVLVLGLtYARTLRYLwRAVDPVAAGSGARRAKrkvtRMILIVAALFcLCWMPHHALI 199
Cdd:cd15136  158 FETEtPVSKAYVIFLLLFNGLAFLIICGC-YIKIYLSV-RGSGRAANSNDTRIAK----RMALLVFTDF-LCWAPIAFFG 230
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767996348 200 LCVWFGqFPLTRATYAlRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15136  231 LTAAFG-LPLISVSNA-KILLVFFYPLNSCANPFLYAIFTKQFRR 273
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
34-244 7.08e-09

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 55.72  E-value: 7.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15214   65 WIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFD 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLT-VCHPAWsaprRRAMDICTF--VFSYLLPVLVLGLTYARTLRYlwravdpvaagsgARRAKRKVTRMILIVAALFCL 190
Cdd:cd15214  145 RFKwMCVAAW----HKEAGYTAFwqVWCALLPFVVMLVCYGFIFRV-------------ARANQCKAFITILVVLGAFVT 207
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 191 CWMPHHALILC-VWFGQfplTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15214  208 TWGPYMVVISTeALWGK---NSVSPQLETLATWLSFTSAVCHPLIYGLWNKTVRK 259
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
33-244 8.87e-09

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 55.61  E-value: 8.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIrypLHSRELRTPRnALAAIGLIWGLSLLFSG-PYLSYYRQSQ 111
Cdd:cd15078   65 RWVFDVAGCVWDGFSNSLFGIVSIMTLTVLAYERYIRV---VHAKVVNFSW-SWRAITYIWLYSLAWTGaPLLGWNRYTL 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSA--PRRRAMDICTFVFSYLLPVLVLGLTYARTLR--YLWRAVDPVAAGSGAR--RAKRKVTRMILIVA 185
Cdd:cd15078  141 EVHGLGCSFDWKSkdPNDTSFVLLFFLGCLVVPLGIMAYCYGHILYeiRMLRSVEDLQTFQVIKilKYEKKVAKMCLLMI 220
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 186 ALFCLCWMPHHALILCVWFGQFPLTRATYAlrILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15078  221 STFLICWMPYAVVSLLVTSGYSKLVTPTIA--IIPSLFAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
37-246 9.03e-09

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 55.46  E-value: 9.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  37 GSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLT 116
Cdd:cd15104   69 QKVLCLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKG 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 117 VCHPAWSAPRRRAMDICTFVFsylLPVLVLGLT-YARTLRYLWRAVDPVA----AGSGARRAKR-----KVTRMILIVAA 186
Cdd:cd15104  149 KCSFFAAFHPRVLLVLSCMVF---FPALLLFVFcYCDILKIARVHSRAIYkvehALARQIHPRRtlsdfKAARTVAVLIG 225
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 187 LFCLCWMPHH-ALILCVWFGQFPLTRatYALRILShLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15104  226 CFLLSWLPFQiTGLVQALCDECKLYD--VLEDYLW-LLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
34-243 9.16e-09

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 55.57  E-value: 9.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNAL--AAIGLIWGLS----LLFSGPYLSYY 107
Cdd:cd15153   65 WPFGRFLCLLCFYLKYLNMYASICFLTCISIQRCFFLLHPFKARDWKRRYDVGisAAVWIVVGLAclpfPLLRSKSLSNN 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 RQSQLANLTVCHPAWSAPrrRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSgarrAKRKVTRMILIVAAL 187
Cdd:cd15153  145 NRSCFADLGMKKLNFGAA--IAMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKQQQSTS----EKQKALRMVRMCAAV 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 188 FCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYA------NSCVNPIVYALVSKHFR 243
Cdd:cd15153  219 FFICFAPYHINFLFYLMVSESIITNCEVSQVILQFHPISlclaslNCCLDPILYYFMTSEFQ 280
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
34-244 9.36e-09

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 55.64  E-value: 9.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL-SYYRQSQL 112
Cdd:cd15318   66 WYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLyTKAVEEGL 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWSAprrramdiCTFVFS----------YLLPVLVLGLTYARTLRYLWRAVDPVAAGS----GARRAKRKVT 178
Cdd:cd15318  146 AELLTSVPCVGS--------CQLLYNklwgwlnfpvFFIPCLIMIGLYVKIFIVAKRQARAIASLLsdtnGASKRERKAA 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 179 RMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRIlshLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15318  218 KTLGIAVGVYLLCWLPFTIDTMVDSLLNFITPPLLFDIII---WFAYFNSACNPLIYVFSYPWFRK 280
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
48-246 1.11e-08

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 55.27  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  48 IFLTMHASSFTLAAVSLDRYLA-IRYPLH--SRELRTprnaLAAIGLIWGLSLLFSG-PYLSYYRQSQLANLTVCHPAWs 123
Cdd:cd15346   79 MFVALSASVFSLLAIAIERYITmLKMKLHngSNSFRS----FLLISACWVISLILGGlPIMGWNCISALSSCSTVLPLY- 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 124 apRRRAMDICTFVFSYLLPVLVLglTYART---LRYLWRAVDPVAAGSGARRAKRK---VTRMILIVAALFCLCWMPHHA 197
Cdd:cd15346  154 --HKHYILFCTTVFTLLLLSIVI--LYCRIyslVRTRSRRLTFRKNIRKASRSSEKsmaLLKTVIIVLSVFIACWAPLFI 229
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767996348 198 LIL----CVWFGQFPLTRATYALrilshLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15346  230 LLLldvgCKVKTCSILFKAEYFL-----VLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
27-243 1.59e-08

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 54.84  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYT-LDGW-VFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTpRNALAAIGLIWGLSLLFSGPYL 104
Cdd:cd15080   57 TMYTsMHGYfVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGE-NHAIMGVAFTWVMALACAAPPL 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 -SYYRQSQLANLTVCHPAWSAPR----RRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTR 179
Cdd:cd15080  136 vGWSRYIPEGMQCSCGIDYYTLKpevnNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTR 215
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 180 MILIVAALFCLCWMPHHALILCVWFGQFPLTRATYAlrILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15080  216 MVIIMVIAFLICWVPYASVAFYIFTHQGSDFGPIFM--TIPAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
25-246 2.00e-08

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 54.47  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  25 WATIYTL-DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPY 103
Cdd:cd15215   55 WVIATSVpLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 104 LSYYRQSQLANLT-VCHPAWSAprRRAMDICTFVFSYLLPVLVLGLTYARTLRylwravdpvaagsGARRAKR-KVTRMI 181
Cdd:cd15215  135 LYGWGQAAFDERNaLCSVIWGS--SYSYTILSVVSSFVLPVIIMLACYSMVFR-------------AARRCYHcKAAKVI 199
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767996348 182 LIVAALFCLCWMPHHAL-ILCVWFG-QFPLTRATYALRILshlvsYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15215  200 FIIIFSYVLSMGPYSFLsVLAVWVDtQVPQWVISIILWLF-----FLQCCIHPYIYGYMHKSIKKEF 261
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
28-246 2.62e-08

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 54.42  E-value: 2.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  28 IYTLDG--WVFGSLLCKAVHFLIFLTMHASSFT----LAAVSLDRYLAIRYPLHSRELRTP-------------RNALAA 88
Cdd:cd14996   58 AYFLKGfyWKYQSTQCRIANFFGTLVIHVSMCVsiliLSWIAISRYATLMKHDSATQKQSCyekifyghflkrfRQPKFA 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  89 IGL---IWGLSLLFSGPYLSYY--RQSQLANLTVCHpawsaprRRAMDI------------CTFVFSYLLPVLvlgLTYA 151
Cdd:cd14996  138 RYLciyIWGVVLCIIIPVVVYYsvREADEDGESLCY-------NRQVELgakgsqiagliaTTFFFLFFLVVL---LSYY 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 152 RTLRYLWRaVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWF-----GQFPLTRATYALRILSHLVSyA 226
Cdd:cd14996  208 SFVNHLRR-IQKNTCISEKDLIYRSVKRNILIIQALLVVCFLPYHIFKPVFYVlhqreDCQQLNYLIETKNILTCLAS-A 285
                        250       260
                 ....*....|....*....|
gi 767996348 227 NSCVNPIVYALVSKHFRKGF 246
Cdd:cd14996  286 RSSTDPIMYLLLDKTFKKTL 305
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-246 2.63e-08

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 54.53  E-value: 2.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQL- 112
Cdd:cd15977   66 WPFGVHVCKLYPFIQKASVGITVLSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPEAIAFDMVEId 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ---ANLTVC--HPAWSAP----RRRAMDICTFVFSYLLPVLVLGLTYA-RTLRYLWRAVDPVAAGSGARRAKRKVTRMIL 182
Cdd:cd15977  146 yrgQTLLVCmlPMEQTSSfmrfYQDVKDWWLFGFYFCLPLACTGVFYTlMSCEMLSIKNGMRIALNDHMKQRREVAKTVF 225
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996348 183 IVAALFCLCWMPHHA---LILCVWFGQFPLTRATYALRILSHLV----SYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15977  226 CLVVIFALCWLPLHLsriLKKTIYDVKDPQRCELLSFLLVMDYTginmASLNSCINPVALYFVSRKFKNCF 296
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
26-246 4.83e-08

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 53.71  E-value: 4.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP--- 102
Cdd:cd15975   63 AQKWPFDDSSFGVFLCKLVPFLQKASVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPeai 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 ---YLSYYRQSQLANLTVCHPA--WSAPRRRAMDICTFVFSYLLPVLVLGLTYA-RTLRYLWRAVDPV-AAGSGARRAKR 175
Cdd:cd15975  143 gfvMVPFEYNGEQYRTCMLNATtkFMNFYVDAKDWWLFGFYFCVPLACTAIFYTlMTCEMLNRRKGSLrIALSEHLKQRR 222
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 176 KVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSY-------ANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15975  223 EVAKTVFCLVVIFALCWFPLHLSRILKKTVYNENDPRRCELLSFLLVMDYisinlatMNSCINPIALYFVSKKFKNCF 300
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
31-244 6.58e-08

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 52.93  E-value: 6.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQS 110
Cdd:cd15149   62 LGPWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQS 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 111 -QLANLTVCHPAWSAPRRR----AMDICTFVFSYLLPVLVlgLTYARTLRYLWRAVDPVAAGSGARRAkrKVTRMILIVA 185
Cdd:cd15149  142 fHEANYTKCARLKSELGIQwhkaSNYICVSIFWVVFLLLI--IFYVAISRKIYKSNQKFRRNSTNMKA--KSSRNIFSIL 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 186 ALFCLCWMPHHALILCVWFGQ----FPLTRAT--YALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15149  218 FVFFVCFVPYHALRIPYTLSQtgadYSCQSKTilYYMKEFTLLLSAANVCLDPIIYFFLCQPFRE 282
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
34-244 6.93e-08

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 52.87  E-value: 6.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPL-HSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQL 112
Cdd:cd15969   65 WNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFgDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVC-----------HPAWSaprrrAMDICTFVFSyllpVLVLGLTYARTLRYLWRAVDPVAAGSgarRAKRKVTRMI 181
Cdd:cd15969  145 DNIHDCsklksplgvkwHTAVS-----YINICIFVAV----LVILIVCYISISRYIYKSSKQFISSS---SRTRKHNQSI 212
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 182 LIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSH------LVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15969  213 RVVVAVFFVCFLPYHLCRIPFTFSQLDKILDCTIKTILYYckeatlFLSACNVCLDPIIYFFMCRSFSQ 281
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
34-242 7.00e-08

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 52.85  E-value: 7.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP-YLSYYRQSQL 112
Cdd:cd15200   66 WRFGATACQVNLFMLSMNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHlLLLDHVQSNS 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWSAPRRRAMDIcTFVFSYLLPVLVLGLTYARTLRYLWRAvdPVAAGSGARRAkrkvTRMILIVAALFCLCW 192
Cdd:cd15200  146 TCLSYDHGTDPSASDRWHRI-LFFLEFFLPLGIILFCIFSIILTLKQR--KLAKQAGPQRA----VKVLAVIVLVYTVCF 218
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767996348 193 MPH----HALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHF 242
Cdd:cd15200  219 LPSilfaLASLVAFKVSQCRSLDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSF 272
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
33-246 9.16e-08

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 52.36  E-value: 9.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRElRTPRNALAAIGLIWGLSLLFSGPYLSYYRQ--- 109
Cdd:cd15331   65 HWFLGPEVCDMWISMDVLCCTASILHLVAIALDRYWAVTNIDYIRR-RTAKRILIMIAVVWFVSLIISIAPLFGWKDedd 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 -SQLANLTVChpawSAPRRRAMDICTFVFSYLLPVLVLGLTYARtlryLWRAvdpvaagsgARRaKRKVTRMILIVAALF 188
Cdd:cd15331  144 lDRVLKTGVC----LISQDYGYTIFSTVGAFYVPLLLMIIIYWK----IYQA---------AKR-ERKAARTLAIITGAF 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 189 CLCWMPhhalilcvwFGQFPLTRATYALRILSHLV-------SYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15331  206 VVCWLP---------FFLVALVMPFCGAWQISRFLesfflwlGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
26-246 1.10e-07

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 52.49  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAI-RYPLHSRelRTPRNALAAIGLIWGLSLLFS-GP 102
Cdd:cd15056   57 GAIELVNNrWIYGETFCLVRTSLDVLLTTASIMHLCCIALDRYYAIcCQPLVYK--MTPLRVAVMLGGCWVIPTFISfLP 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 103 YLSYYRQSQLANLTVCHPAWSAPR-----RRAMDICTFVFSYLLPVLVLGLTY----------ARTLRYLWRAVDPVAAG 167
Cdd:cd15056  135 IMQGWNHIGIEDLIAFNCASGSTScvfmvNKPFAIICSTVAFYIPALLMVLAYyriyvaareqAHQIRSLQRAGSSNHEA 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 168 SGAR----RAKRKVTRMILIVAALFCLCWMPhhaLILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15056  215 DQHRnsrmRTETKAAKTLGIIMGCFCVCWAP---FFVTNIVDPFIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFR 291

                 ...
gi 767996348 244 KGF 246
Cdd:cd15056  292 RAF 294
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
44-244 1.46e-07

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 51.72  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  44 VHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSqlanltvchpaws 123
Cdd:cd15351   82 IDTMICSSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVYYNSN------------- 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 124 aprrrAMDICTFVFSYLLPVLVLGL---------TYARTLRYLWRAVDPVAAGSGARRAkrkVTRMILIvaALFCLCWMP 194
Cdd:cd15351  149 -----AVILCLIVFFLFMLVLMLVLyihmfilacRHSQSISSQQRRQCPHQQTASLKGA---ITLTILL--GIFFLCWGP 218
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767996348 195 HH-ALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15351  219 FFlHLTLIVTCPTHPFCLCYFKYFNLFLILIICNSIIDPLIYAFRSQELRK 269
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
35-246 1.65e-07

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 51.86  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  35 VFGSLLCkavhflifLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQlan 114
Cdd:cd15354   81 VFDSLIC--------ISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYSESTY--- 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 115 LTVChpawsaprrramdICTFVFSYLLPVLVLgltYARTLRYLWRAVDPVAAGSGA----RRAKRKVTRMILIVAALFCL 190
Cdd:cd15354  150 VIIC-------------LITMFFAMLFLMVSL---YIHMFLLARTHVKRIAALPGYnsvrQRTSMKGAVTLTILLGIFIV 213
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 191 CWMP---HHALILCVwfgqfplTRATYALRILSHLVSY-----ANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15354  214 CWAPfflHLILMISC-------PQNLYCVCFMSHFNMYlilimCNSVIDPLIYAFRSQEMRKTF 270
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-246 1.83e-07

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 51.72  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSqlanltvchpawsapr 126
Cdd:cd15103   85 MICSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYSDSV---------------- 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 127 rraMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGAR----RAKRKVTRMILIVAALFCLCWMPHHA-LILC 201
Cdd:cd15103  149 ---PVIICLISMFFAMLVLMASLYVHMFLLARSHVKKIAALPGQRstrqRANMKGAVTLTILLGVFIFCWAPFFLhLTLM 225
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767996348 202 VWFGQFPltratYALRILSHLVSY-----ANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15103  226 ISCPSNP-----YCACYMSHFNVYlilimCNSVIDPLIYAFRSQELRKTF 270
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
33-197 1.84e-07

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 51.67  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIW-------GLSLLFSGPYLS 105
Cdd:cd14983   65 AWTLPAVLCPLYNLAHFSTLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWalvifhvTLVFILETSGGT 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLANLTVCHPAWS-------APRRRAMDICTFvfsyLLPVLVLGLTYARTLRYLWRavdpvaaGSGARRAKRKVT 178
Cdd:cd14983  145 LDINTPVGNSSTCYENFTpeqlallAPVRLELSLVLF----FLPLAITAFCYVRCIRILVR-------SRLHERRKRRAV 213
                        170
                 ....*....|....*....
gi 767996348 179 RMILIVAALFCLCWMPHHA 197
Cdd:cd14983  214 RVAVSTLLTFVVCFGPYNI 232
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
50-244 2.12e-07

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 51.38  E-value: 2.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  50 LTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSgpYLSyyrqsqLANLTVCHPAWSAPRRRA 129
Cdd:cd15341   82 MSFTASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIA--YLP------LMGWNCCPLNSPCSELFP 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 130 MDICTFVFSYLLPVLVLGL----TYARTlryLWRAVDPVAAGSGAR-RAKRKVTRMIL---------IVAALFCLCWMPh 195
Cdd:cd15341  154 LIPNDYLLSWLLLVAILLSgiiyTYGHV---LWKAHKHVVYMEKHQdQQGPGNARMRLdvrlaktlgLVLAVLLICWSP- 229
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767996348 196 hALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15341  230 -VLALMMHSLFTSLSDHIKKAFAFCSTLCLVNSMVNPIIYALRSRELRS 277
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-246 3.80e-07

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 50.98  E-value: 3.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  36 FGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP--------YLSYY 107
Cdd:cd15128   73 FGQFLCKLVPFIQKASVGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPeaigfdmvRFNYK 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 RQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYA----RTLRYlwRAVDPVAAGSGARRAKRKVTRMILI 183
Cdd:cd15128  153 GVTLRTCLLRPETSFMKFYIDVKDWWLFGFYFCLPLVCTAIFYTlmtcEMLRK--RNGMLRIALNEHLKQRREVAKTVFC 230
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 184 VAALFCLCWMPHH---ALILCVWFGQFP----LTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15128  231 LVVIFALCWLPLHlsrILKLTVYDQNDPnrceLLSFLLVLDYFGINLATLNSCINPIALYFVSRKFKNCF 300
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
34-246 4.01e-07

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 50.57  E-value: 4.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP--YLSYYRQSQ 111
Cdd:cd15054   66 WVLARDFCPIWYAFDVMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLpiELGWHELGH 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANLTVCHPAWSAPRRRAMDICTF-----VFSYLLPVLVLGLTYARTLRylwravdpvaagsgARRAKRKVTRMILIVAA 186
Cdd:cd15054  146 ERTLPNLTSGTVEGQCRLLVSLPYalvasCLTFFLPSGAICFTYCRILL--------------AARKALKASLTLGILLG 211
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 187 LFCLCWMPH------HALILCVWFGQFpltratyalRILSHLvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15054  212 MFFVTWLPFfvanvvQAVCDCVSPGLF---------DVLTWL-GYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
47-246 4.39e-07

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 50.66  E-value: 4.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWgLSLLFSGPYLSYYRQSQLanLTVChpawsapr 126
Cdd:cd15352   85 MICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIW-VVCIVCGIVFIVYSESKT--VIVC-------- 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 127 rramdICTFVFSYLL---PVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHA-LILCV 202
Cdd:cd15352  154 -----LITMFFAMLVlmaTLYVHMFLFARLHVKRIAALPPAVDGAPQQRSCMKGAVTITILLGVFIVCWAPFFLhLILII 228
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767996348 203 WFGQFPltratYALRILSHLVSY-----ANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15352  229 SCPHNP-----YCLCYTSHFNTYlvlimCNSVIDPLIYAFRSLEMRKTF 272
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
47-244 4.40e-07

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 50.55  E-value: 4.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSgpYLSYYRQSQLANLTVCHPAWSAPR 126
Cdd:cd15349   78 LLFTALAASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIG--FLPLLGWNCLCDFRSCSSLLPLYS 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 127 RRAMDICTFVFSYLLpvLVLGLTYArTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQ 206
Cdd:cd15349  156 KSYILFCLVIFFIIL--LTIIGLYF-AIYCLVRASGQRVISARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCS 232
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767996348 207 fplTRATYALRILSHLVSYA--NSCVNPIVYALVSKHFRK 244
Cdd:cd15349  233 ---SRSCKPLFGMEWVLALAvlNSAINPLIYSFRSLEVRR 269
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
32-243 4.58e-07

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 50.53  E-value: 4.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  32 DGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSG----PYLSYY 107
Cdd:cd15220   63 LGVVFGEAECRVYIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLlpvlGWPSYG 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 RQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwravdpvaaGSGarrakrKVTRMILIVAAL 187
Cdd:cd15220  143 GPAPIAARHCSLHWSHSGHRGVFVVLFALVCFLLPLLLILVVYCGVFKVF---------GGG------KAALTLAAIVGQ 207
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 188 FCLCWMPHHALILCVWFGQFPLTRAtyALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15220  208 FLCCWLPYFAFHLYSALAASPVSGG--EAEEVVTWLAYSCFAVNPFFYGLLNRQIR 261
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
48-246 6.57e-07

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 49.82  E-value: 6.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  48 IFLTMHASSFTLAAVSLDRYLAIrYPLHSRELRTPRNALAAIGLIWGLSLLFSG-PYLSYYRQSQLANLTVCHPAWSapr 126
Cdd:cd15345   79 MFVALGASTFSLLAIAIERHLTM-IKMRPYDANKRYRVFLLIGTCWLISVLLGAlPILGWNCLDNLPDCSTILPLYS--- 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 127 RRAMDICTFVFSYLLPVLVLglTYARTLRYLWRAVDPVAAGSGARRAkRKVTRMILIVAALFCLCWMPHHALIL----CV 202
Cdd:cd15345  155 KKYVAFCISIFIAILVAIVI--LYARIYILVKSSSRRVTNHRNSERS-MALLRTVVIVVGVFIACWSPLFILLLidvaCE 231
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767996348 203 WFGQFPLTRATY--ALRILshlvsyaNSCVNPIVYALVSKHFRKGF 246
Cdd:cd15345  232 VKQCPILYKADWfiALAVL-------NSAMNPIIYTLASKEMRRAF 270
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
34-244 6.58e-07

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 50.20  E-value: 6.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYY-RQSQL 112
Cdd:cd15150   65 WPLRGFVCQVTSVIFYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILTnRQPTP 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWS----APRRRAMDICTFVFSYLLPVLVlgLTYARTLRYLWRAVdpVAAGSGARRAKRKVTRMILIVAALF 188
Cdd:cd15150  145 KNVKKCSLLKSefglVWHEIVNYICQVIFWVNFLIVI--VCYTLITKELYKSY--KRTRGVGKVSRKKVNVKVFIIIAVF 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 189 CLCWMPHHalilcvwFGQFPL----TRATY---ALRILSHL------VSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15150  221 FICFVPFH-------FARIPYtlsqTRDVFdctAKNTLFYVkestlwLTSLNACLDPFIYFFLCKSFRN 282
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
41-243 7.51e-07

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 49.76  E-value: 7.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSY-YRQSQLANLTVCH 119
Cdd:cd15167   73 CQVTACLIYINMYLSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMAIpIKTIEEKPGVGCA 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 120 PAWSAPRRR----AMDICTFVFsYLLPVLVLgLTYARTLRYLWRAVDpvaagSGARRAKRKVTRMILIVAALFCLCWMPH 195
Cdd:cd15167  153 DFKTEFGRHwhvlTNFICMAIF-LNFSAIIL-ISNFLVIRKLYRNKD-----SEEYRNARQALVNILLVTAGYVICFVPY 225
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767996348 196 HALILCVWFGQF------PLTRATYALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15167  226 HIVRIPYTLSQSevitdcSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
27-246 1.20e-06

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 49.15  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  27 TIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLsY 106
Cdd:cd15335   59 TYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPL-F 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 107 YRQSQLANLTvchpawSAPRRRAMDICTFVFS----YLLPVLVLGLTYARTLrylwravdpvaagSGARRaKRKVTRMIL 182
Cdd:cd15335  138 WRNHHDANIP------SQCIIQHDHVIYTIYStfgaFYIPLTLILILYYRIY-------------HAASR-ERKAARILG 197
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 183 IVAALFCLCWMPHHALILCVwfGQFPLTRATYALRILSHLvSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15335  198 LILGAFILSWLPFFIKELIV--GLSVMTVSPEVADFLTWL-GYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
26-244 1.35e-06

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 49.08  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDgWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIrypLHSRELRTPRNALAAIGLIWGLSLLFSGPYLS 105
Cdd:cd15403   59 VTIITVD-WHFGAHFCRISAMLYWFFVLEGVAILLIISVDRFLII---VQRQDKLNPHRAKVMIAISWVLSFCISFPSVV 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 106 YYRQSQLanltvchPAWS---------APRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARrAKRK 176
Cdd:cd15403  135 GWTLVEV-------PARApqcvlgyteSPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIHNHADSL-CLSQ 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 177 VTRM------------------------ILIVAALFCLCWMPHHAL-ILCVWFGQFPLTRATYALRILSHLVSYANSCVN 231
Cdd:cd15403  207 VSKLglmglqrphqmnvdmsfktrafttILILFVGFSLCWLPHTVFsLLSVFSRRFYYSSSFYPISTCVLWLSYLKSVFN 286
                        250
                 ....*....|...
gi 767996348 232 PIVYALVSKHFRK 244
Cdd:cd15403  287 PVIYCWRIKKFRE 299
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
47-244 1.50e-06

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 48.63  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSG-PYLSYyrqSQLANLTVCHPAWSAP 125
Cdd:cd15100   75 LLVAAFSASVCSLLAITVDRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLlPVLGW---NCLREGSSCSVVRPLT 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 126 RRRAMDICTfvfSYLLPVLVLGLTYARTLRYLWRAVDPVAA-----GSGARRAKRKVTRMILIVAALFCLCWMPhHALIL 200
Cdd:cd15100  152 KNHLAVLAV---AFLLVFALMLQLYAQICRIVLRHAHQIALqrhflAPSHYVATRKGVSTLALILGTFAACWIP-FAVYC 227
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767996348 201 CVWFGQFPLTRaTYAlrilSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15100  228 LLGDGSSPALY-TYA----TLLPATYNSMINPIIYAFRNQDIQK 266
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
47-246 2.26e-06

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 48.48  E-value: 2.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS-GPYLSYYRQSQLANLTVCHPAwsap 125
Cdd:cd15961   75 LIVASFSASVCSLLAITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGlLPVMGWNCLADESTCSVVRPL---- 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 126 rrRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVA-----AGSGARRAKRKVTRMILIVAALFCLCWMPHHALIL 200
Cdd:cd15961  151 --TKNNAAILSVSFLLMFALMLQLYIQICKIVMRHAHQIAlqhhfLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSL 228
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767996348 201 CVWFGQFPLTraTYAlrilSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15961  229 IADYTYPSIY--TYA----TLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
46-246 3.12e-06

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 47.98  E-value: 3.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  46 FLIFLTMHASSFTLAAVSL-----DRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSG-PYLsyyrqsqlanltvch 119
Cdd:cd15340   73 FLFKLGGVTASFTASVGSLfltaiDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVlPLL--------------- 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 120 pAWSAPRRRAmdICTFVF-----SYLL------PVLVLGLTYArTLRYLWR----AVDPVAAGS-------GARRAKRKV 177
Cdd:cd15340  138 -GWNCKKLNS--VCSDIFplideTYLMfwigvtSVLLLFIVYA-YMYILWKahhhAVRMLQRGTqksiivyTSEDGKVQT 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 178 TR-------------MILIVAALFcLCWMPHHALILCVWFGQF-PLTRATYAlriLSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15340  214 TRpdqtrmdirlaktLVLILVVLI-ICWGPLLAIMVYDVFGKMnKLIKTVFA---FCSMLCLLNSTVNPIIYALRSKDLR 289

                 ...
gi 767996348 244 KGF 246
Cdd:cd15340  290 HAF 292
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
34-244 4.05e-06

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 47.55  E-value: 4.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGP--YLSYYRQ-- 109
Cdd:cd15316   66 WYFGESFCTFHTCCDVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSvfYTGVNDDgl 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 SQLANLTVCHPAWSAPRRRAMDICTFVfSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSG-------------ARRaKRK 176
Cdd:cd15316  146 EELVNALNCVGGCQIILNQNWVLVDFL-LFFIPTFAMIILYGKIFLVAKQQARKIEMTSSkaesssesykdrvARR-ERK 223
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767996348 177 VTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILShlvSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15316  224 AAKTLGITVIAFLVSWLPYLIDVLIDAFMNFITPPYIYEICCWC---AYYNSAMNPLIYALFYPWFRK 288
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
41-246 5.09e-06

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 47.17  E-value: 5.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLH-SRELRTpRNALAAIGLIWGLSLLFSgpYLSYYRQSQLANLTVCH 119
Cdd:cd15359   80 CSTAGFFTVFASELSVYTLTVITLERWHTITYAMQlDRKLRL-RHAILIMLGGWVFSLLIA--VLPLVGVSNYMKVSICL 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 120 PawsaprrraMDICTFVF-SYLLPVLVLGLT--------YARtLRYLWRAVDPVAAGSGARRAKRKVtrmILIVAALFCL 190
Cdd:cd15359  157 P---------MDIETLLSqAYILLILVLNVIaflvicacYIK-IYLAVQNPELVAKNKDTKIAKRMA---ILIFTDFTCM 223
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 191 CWMPHHALILCVwfgQFPLTRATYAlRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15359  224 APISFFAISAAF---KVPLITVTNS-KILLVLFYPINSCANPFLYAIFTKAFRRDF 275
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
49-246 8.87e-06

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 46.34  E-value: 8.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  49 FLTMHASSFTLAAVSLDRYLAI-RYPLHSRElRTPRNALAaIGLIWGLSLLFSG-PYLSYYRQSQLANLTVCHPAWSapR 126
Cdd:cd15347   80 FITLSASVFSLLAIAIERHVAItKVKLYGSD-KNCRMVLL-IGACWVISIVLGGlPILGWNCIGNLEDCSTVLPLYS--K 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 127 RRAMDICTFVFSYLLPVLVLgltYARtLRYLWRAVDPVAAGSGARRAKRKVTrmilIVAALFCLCWMPHHALIL----CV 202
Cdd:cd15347  156 HYILFVVTIFSIILLSIVIL---YVR-IYCIVRSSHAEMAAPQTLALLKTVT----IVLGVFIVCWLPAFIILLldtsCK 227
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 767996348 203 WFGQFPLTRATYALRilshlVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15347  228 VKSCPILYKADYFFS-----VATLNSALNPVIYTLRSKDMRKEF 266
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
31-244 9.61e-06

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 46.31  E-value: 9.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQ- 109
Cdd:cd15151   62 LGPWQLRAFVCRFSAVVFYITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKp 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 SQLANLTVC----HPAWSAPRRRAMDICTFVFSYLLPVLVLglTYARTLRYLWRAVdpVAAGSGARRAKRKVTRMILIVA 185
Cdd:cd15151  142 ATPISVKKCaslkSPLGLKWHEVVNYICQFIFWGVFALMVL--FYTIISKKVYESY--KKSRSKDNKASKKTKAKVFIIV 217
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 186 ALFCLCWMPHHalilcvwFGQFPLT-------------RATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15151  218 AVFFVCFAPFH-------FVRVPYTlsqtgkitdcqlqNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQ 282
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
41-330 1.20e-05

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 46.73  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRElRTPRNALAAIGLIWGLSLLFSGPYLSYyrqsqlanLTVCHP 120
Cdd:PHA03235 105 CKFASLLYYASCTVGFATVALIAADRYRVIHQRTRARS-SAYRSTYKILGLTWFASLICSGPAPVY--------TTVVAH 175
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 121 AWSAPRRRAMDICTFVFSYLLPVLVLGlTYARTLRYLWrAVDPVAAGSG---------ARRAKRKVTRMILIVAALFC-- 189
Cdd:PHA03235 176 DDVDPEAPGYETCVIYFRADQVKTVLS-TFKVLLTLVW-GIAPVVMMTWfytffyrtlKRASYKKRSRTLTFVCILLLsf 253
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 190 LCW-------MPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAG-LLGRapgRA 261
Cdd:PHA03235 254 LCLqtpfvaiMIFDSYATLIWPSDCEHINLRDAVSTLSRLVPNLHCLLNPILYAFLGNDFLKRFRQCFRGeLFSR---RA 330
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 262 SGRVCAAARGTHSGSVLERESSDlLHMSEAAGALRPCPGASQPCILepcPGPSWQG-PKAGDSILTVDVA 330
Cdd:PHA03235 331 FLRSRQKCGATAISTVCALPSKT-STLSTSSGTRQQKIKRSQSLNL---PNATPKNkPKTRCAQNDTDNA 396
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
34-246 1.84e-05

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 45.79  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL----SYYRQ 109
Cdd:cd15218   67 WTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVldvgTYSFI 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 SQLANLTVCHPAWsaprrRAMDICTFVFSYLLPVLVLGLTYARTLRYL------------------WRAVDPVAAG---- 167
Cdd:cd15218  147 REEDQCTFQHRSF-----RANDSLGFMLLLALILLATQLVYLKLIFFVhdrrkmkpvqfvaavsqnWTFHGPGASGqaaa 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 168 ------------------------SGARR--------AKRKVTRMILIVAALFCLCWMPHhaLILCVW--FGQFPLTRAT 213
Cdd:cd15218  222 nwlagfgrgptpptllgirqnantTGRRRllvldefkMEKRISRMFYIMTFLFLTLWGPY--LVACYWrvFARGPVVPGG 299
                        250       260       270
                 ....*....|....*....|....*....|...
gi 767996348 214 YALRILshLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15218  300 FLTAAV--WMSFAQAGINPFVCIFSNRELRRCF 330
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
34-246 2.30e-05

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 45.33  E-value: 2.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAI----RYPLHSRElrtpRNALAAIGLIWGLSLLFS-GPYLSYYR 108
Cdd:cd15328   67 WQLGRSLCQVWISFDVLCCTASIWNVTAIALDRYWSItrhlEYTLRTRR----RISNVMIALTWALSAVISlAPLLFGWG 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVCHpawsAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRylwravdpvaagsgARRAKRKVTRMILIVAALF 188
Cdd:cd15328  143 ETYSEDSEECQ----VSQEPSYTVFSTFGAFYLPLCVVLFVYWKIYK--------------AAQKEKRAALMVGILIGVF 204
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 189 CLCWMPHH--ALILCVWFGQFPLTRATYALrilshLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15328  205 VLCWIPFFltELISPLCSCDIPPIWKSIFL-----WLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
35-246 2.42e-05

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 45.28  E-value: 2.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  35 VFGSLLCKavhfliflTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSqlan 114
Cdd:cd15353   80 VIDSVICS--------SLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFIIYSDSS---- 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 115 ltvchpawsaprrrAMDICTFVFSYLLPVLVLGLtYARTLRYLWRAVDPVAA--GSGARR--AKRKVTRMILIVAALFCL 190
Cdd:cd15353  148 --------------VVIICLISMFFTMLALMASL-YVHMFLLARLHIKRIAVlpGTGPIRqgANMKGAITLTILLGVFVV 212
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 191 CWMPHHA-LILCVWFGQFPltratYALRILSHLVSY-----ANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15353  213 CWAPFFLhLIFYISCPRNP-----YCVCFMSHFNMYlilimCNSVIDPLIYAFRSQELRKTF 269
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
29-246 2.56e-05

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 45.17  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  29 YTLDG-WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRT-PRNALAAIGLIWGLSLLFSGPYL-- 104
Cdd:cd15296   60 YVLTGrWKFGRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVSYRAQKGmTRQAVLKMVLVWVLAFLLYGPAIis 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 -SYYRQSQLANLTVCHPAWSAPRRRAMDICTF-VFSYLLPVLVLGLTYARTLRylwravdpvaagsgARRAK----RKVT 178
Cdd:cd15296  140 wEYIAGGSIIPEGECYAEFFYNWYFLMTASTLeFFTPFISVTYFNLSIYLNIQ--------------KRRFRlsrdKKVA 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 179 RMILIVAALFCLCWMPHHALIL--------CVWfgqfpltratYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15296  206 KSLAIIVCVFGLCWAPYTLLMIiraachghCVP----------DYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
41-246 3.44e-05

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 44.85  E-value: 3.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLH-SRELRTPRnalAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCH 119
Cdd:cd15360   80 CAAAGFFTVFASELSVYTLTVITLERWHTITYAMQlDRKVRLRH---AAVIMVGGWIFAFTVALLPIFGISSYMKVSICL 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 120 PawsaprrraMDICT-FVFSYLLPVLVLGLTYARTLRYLW-------RAVDPVAAGSGARRAKRKVtrmILIVAALFCLC 191
Cdd:cd15360  157 P---------MDIESpLSQAYIIFILVLNVLAFLIICACYikiyltvRNPNFVSSNSDTKIAKRMA---VLIFTDFLCMA 224
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 192 WMPHHALILCVwfgQFPLTRATYAlRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15360  225 PISFFAISASL---KVPLITVSKS-KILLVLFYPINSCANPFLYAIFTKTFRRDF 275
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
34-243 4.26e-05

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 44.44  E-value: 4.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIrypLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQL- 112
Cdd:cd15404   66 WIFGDAFCRVSAMFFWLFVMEGVAILLIISIDRFLII---VQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIp 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANLTVCHPAWSA-PRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLwravdpvaagsgaRRAKRKVTRMILIVAALFCLC 191
Cdd:cd15404  143 SRAPQCVFGYTTnPGYQAYVILIMLIFFFIPFMVMLYSFMGILNTV-------------RSFKTRAFTTILILFIVFTVC 209
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767996348 192 WMPHHALILCVWFGQFPLTRATYaLRILSHL--VSYANSCVNPIVYALVSKHFR 243
Cdd:cd15404  210 WAPFTTYSLVATFNSHFYHKHNF-FEISTWLlwLCYLKSALNPLIYYWRIKKFR 262
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
34-243 7.19e-05

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 43.74  E-value: 7.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRtprNALAAIGLI--WGLSLLFSGPYLSYYRQSQ 111
Cdd:cd15081   78 FILGHPMCVLEGFTVSVCGITGLWSLTIISWERWVVVCKPFGNIKFD---GKLAIVGIIfsWVWSAVWCAPPIFGWSRYW 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 112 LANL-TVCHP----AWSAPRRRAMDICTFVFSYLLPVLVLGLTYARtlryLWRAVDPVAA----GSGARRAKRKVTRMIL 182
Cdd:cd15081  155 PHGLkTSCGPdvfsGSSDPGVQSYMIVLMITCCIIPLAIIILCYLQ----VWLAIRAVAQqqkeSESTQKAEKEVSRMVV 230
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767996348 183 IVAALFCLCWMPHhalilcVWFGQFPLTRATYALRILSHLVS--YANSCV--NPIVYALVSKHFR 243
Cdd:cd15081  231 VMIFAYCFCWGPY------TFFACFAAANPGYAFHPLAAALPayFAKSATiyNPIIYVFMNRQFR 289
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
41-244 7.46e-05

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 43.74  E-value: 7.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLH-SRELRTpRNALAAIGLIWGLSLLFSgpYLSYYRQSQLANLTVCH 119
Cdd:cd15964   80 CNTAGFFTVFASELSVYTLTVITLERWYAITFAMRlDRKIRL-RHASAIMLGGWVFCFLLA--LLPLVGVSSYAKVSICL 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 120 PA-WSAPRRRAMDICTFVFSyLLPVLVLGLTYARtlryLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHAL 198
Cdd:cd15964  157 PMdTETPLAQAYIVFVLMLN-IIAFVIICACYIK----IYITVRNPQYKSGDKDTKIAKRMAVLIFTDFICMAPISFYAL 231
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767996348 199 ILCVwfgQFPLTRATYAlRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15964  232 SAIL---NKPLITVSNS-KILLVLFYPLNSCANPFLYAIFTKAFRR 273
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
48-244 8.55e-05

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 43.66  E-value: 8.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  48 IFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRnALAAIGLIWGLSLLFSgpYLSYYRQSQLANLTVCHPAWSAPRR 127
Cdd:cd15348   79 VFITLTASVFSLLAIAIERHITMVRMKPYPGDKRGR-MFLLIGAAWLVSILLG--VLPILGWNCLGNLDACSTVLPLYAK 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 128 RAMDICTFVFSYLLPVLVLglTYARTLRYLWRAVDPVAAGSGAR-RAKRKVTRMIL-----IVAALFCLCWMPHHALIL- 200
Cdd:cd15348  156 SYILFCITVFLAILAAIVV--LYARIYRIVKANSQRLGALPTRKgRARRSQKYLALlktvtIVLGTFVACWLPLFLLLLl 233
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767996348 201 ---CVWFGQFPLTRATYALRIlshlvSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15348  234 dvsCPAQACPVLLKADYFLGL-----AMINSLLNPIIYTLTSRDMRR 275
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
38-243 8.82e-05

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 43.61  E-value: 8.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  38 SLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPylsYYRQSQLanltv 117
Cdd:cd15129   72 HALIHTVSVLEFAANHASIWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGIP---FYWWSDM----- 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 118 chpaWSAPRR-RAMD---ICTFVFS-YLLPVLVLGLTYARTLRYLWRAvdpvAAGSGARRAKRKVTRMILIVAALFCLCW 192
Cdd:cd15129  144 ----WRDSHPpTTLDkvlKWTHCFIiYFIPCTIFLVTNSVIIHKLRRR----KGRSGPQRRSGKTTAILLAITTVFAVLW 215
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767996348 193 MPHHALILC-VWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFR 243
Cdd:cd15129  216 APRTVVIIYhLYVSSVNRDWRVHLALDLANMLAMLNTAVNFFLYCFVSKRFR 267
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
26-245 1.03e-04

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 43.12  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  26 ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIryplHSRELRTPRNALAAIGLIWGLSLLFSG-PYL 104
Cdd:cd15072   57 ASSSLLRRWPYGSEGCQAHGFQGFFTALASICSSAAIAWDRYHHY----CTRSKLQWSTAISLVLFVWLFSAFWAAmPLL 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 105 SYYRQSQLANLTVCHPAWSAPRRRAMD-ICTF-VFSYLLPVLVLGLTYARTLRYLWRavdpvaagSGARRAKRKVTRMIL 182
Cdd:cd15072  133 GWGEYDYEPLGTCCTLDYSKGDRNYVSyLFTMaFFNFILPLFILLTSYSSIEQKLKK--------EGHLRFNTGLPLLTL 204
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767996348 183 IvaalfcLCWMPHhaLILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKG 245
Cdd:cd15072  205 L------ICWGPY--AILALYAAITDVTSISPKLRMVPALLAKTSPTINAILYALGNENYRGG 259
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
34-244 1.41e-04

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 42.94  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHsRELRTPRNALAAIgLIWGLSLLFSGPYLSYYRQSQLA 113
Cdd:cd15006   68 WIYTLLFCKVIKFLHKVFCSVTVLSFAAIALDRYYSVLYPLE-RKISDAKSRDLVI-YIWAHAVVASVPVFAVTNVTDIY 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 114 NLTVCHPAWSAPRRRAMDICTF-VFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVT------------RM 180
Cdd:cd15006  146 AMSTCTESWGYSLGHLVYVIIYnITTVILPVAVVFLFMILIRRALSASQKKKVIIAALRTPQNTISipyvsqreaelhAM 225
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767996348 181 ILIVAALFCLCWMPHHALIlcVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15006  226 LLSMVLVFILCSVPYATLV--IYRTILNISDISVFLLLTAIWLPKVSLLANPLLFLTVNKSVRK 287
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
47-246 1.52e-04

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 42.88  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAI-RYPLHSRelRTPRNALAAIGLIWGLSLLFSG-PYLSYyrqSQLANLTVCHPAwsA 124
Cdd:cd15101   78 LLDTSLTASVANLLAIAVERHISVmRMQLHSR--LSNRRVVVLIVLVWTMAIVMGAiPSVGW---NCLCAIDACSNM--A 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 125 PRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVT----RMILIVAALFCLCWMPHHALIL 200
Cdd:cd15101  151 PLYSRSYLVFWAISNLVTFLVMVVVYARIFVYVRRRTNRMSPHTSGSIRNRDTMmsllKTVVIVLGAFVVCWTPGLVVLL 230
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 767996348 201 CVWFGQFPLTRATYALRILshLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15101  231 LDGLCCRQCNVLAVEKFFL--LLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
59-238 1.60e-04

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 42.77  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  59 LAAVSLDRYLAIRYPLHSRELRtPRNALAAI-GLIWGLSLLFS-------GPYLSYYRQSqlanltVChpawsaprrRAM 130
Cdd:cd15107   89 ITAISIERCLSVMWPIWYHCQR-PRHTSAVIcTLLWVLSLLLSllegkgcGFLFSTYDYY------WC---------WTL 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 131 DICTFVFSYLLPVLVLGLTYARTLRYLWravdpvaagsGARRAKrkVTRM---ILIVAALFCLCWMPHHAL-ILCVWFGQ 206
Cdd:cd15107  153 DLITTAWLIVLFVVLSGSSLALLVRIFC----------GSHRIP--VTRLyvtIALTVLVFLIFGLPFGIYwFLLKWIEE 220
                        170       180       190
                 ....*....|....*....|....*....|..
gi 767996348 207 FPLTRATYALRILShLVSYANSCVNPIVYALV 238
Cdd:cd15107  221 FYIVPCCGFYEVIL-FLSCVNSCANPIIYFLV 251
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
46-200 1.61e-04

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 42.82  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  46 FLIFLtmhassFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLF-SGPYLSYYRQSQLANLTvcHPAWSA 124
Cdd:cd15905   79 FLSFL------ANLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFaCLPALGWNNWTPGSNCS--YKQVFP 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 125 PRRRAMDICTFVFSYLLPVLVLGLTYARTLRY-------LWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHA 197
Cdd:cd15905  151 AAYIYLEVYGLVLPSILAIAFMSVRVLAVARRqlqdickLLRAVQRDGPSELEQQLNLRYAKCIAGVSLTFLVCWVPYIA 230

                 ...
gi 767996348 198 LIL 200
Cdd:cd15905  231 YLL 233
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
47-246 1.92e-04

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 42.48  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAI-RYPLHSRelRTPRNALAAIGLIWGLSLLFSgpYLSYYRQSQLANLTVChpAWSAP 125
Cdd:cd15342   78 LLDTSLTASVANLLAIAVERHQTIfTMQLHSK--MSNQRVVILIFGIWMVALILG--LIPAMGWNCLCDLKRC--STMAP 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 126 RRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVT----RMILIVAALFCLCWMPHHALILC 201
Cdd:cd15342  152 LYSRSYLVFWALSNLLTFLIMVAVYTRIFIYVRRKSQRMSEHHSSHPRYRETVlglmKTVVIILGAFVVCWTPGQVVLLL 231
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767996348 202 VWFGQFPLTRATYALRILshLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15342  232 DGLGCESCNVLAYEKYFL--LLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
31-244 2.23e-04

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 42.12  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  31 LDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLA-IRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYY-- 107
Cdd:cd15171   61 WHGGSLGNPTCKVLVALSSVGLHSEALFNVLLTVQASRVfFHGRLASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYkp 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 108 ---RQSQLANLTVCH------PAWSAPRRRAMDICTFVFsyllPVLVLGLTYARTLRylwravdpvaaGSGARRAKRKVT 178
Cdd:cd15171  141 qmdSQKSKCAFSRPHflpaeeTFWKYFLTLKMNIVVLVF----PLLVFIICCVQLRK-----------TQRFRERQRDLS 205
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 179 RMILIVAALFCLCWMPHH-ALILCVWFGQFPLT--RATYALRI---LSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15171  206 KLVFAIMVVFLLMWAPYNiALFLSAFKEHFSLRdcKSSYHLDAsvqVTKLIATTHCCVNPLLYALLDPAFRR 277
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
51-236 4.41e-04

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 41.40  E-value: 4.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  51 TMHASSFTLAAVSLDRYLAI-RYPLHSRelRTPRNALAAIGLIWGLSLLFSG-PYLSYyrqSQLANLTVCHPAwsAPRRR 128
Cdd:cd15343   82 SLSASLTNLLVIAVERHISImRMKVHSN--LTKRRVTLLIALVWAIAIFMGAvPTLGW---NCICNISACSSL--APIYS 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 129 AMDICTFVFSYLLPVLVLGLTYARTLRYLWR---AVDPVAAGS-GARRAKRKVTRMILIVAALFCLCWMPHHALIL---- 200
Cdd:cd15343  155 RSYLVFWSVSNLVVFLIMVVVYLRIYVYVQRktnVLSPHTSGSiNRRRTPIKLMKTVMTVLGAFVICWTPGLVVLLldgl 234
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 767996348 201 -CVWFGQFPLTRATYALRILshlvsyaNSCVNPIVYA 236
Cdd:cd15343  235 nCTRCGVQHVKRWFLLLALL-------NSVMNPIIYS 264
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
47-246 4.47e-04

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 41.37  E-value: 4.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAI-RYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLAnltvCHPAWSAP 125
Cdd:cd15211   77 LLFLGLTVSLLSHSLIALNRYVLItKLPAVYQALYQKRNTEWMIALSWALALGLLLPWLTSFRYPTKS----CHDSADGS 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 126 RRRAMDICTFVFSYLLPVLVLGLT------YARTLRYLWRAV--------DPVAAGSGARRAKRKVTRM-ILIVAALFCL 190
Cdd:cd15211  153 FAVVSVLSSRYPALLLAFTVLGQTalvlhcYFGIFRRVQISVkrvsvlnfQIVNNLPYSRPRKDKRLGLyVLLVCCVFLL 232
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996348 191 CWMPHHALILCVWFGQFPltratYALRILSHLVSYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15211  233 TTEPLVWVSLAGLFVPVP-----VALQTASWLLFCTLFVLNPFLYTWKNEEFRRSF 283
7tmA_PGE2_EP2 cd15139
prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G ...
30-239 4.53e-04

prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP2, also called prostanoid EP2 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP2 receptor by PGE2 causes cAMP accumulation through G(s) protein activation, which subsequently produces smooth muscle relaxation and mediates the systemic vasodepressor response to PGE2. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320267 [Multi-domain]  Cd Length: 299  Bit Score: 41.30  E-value: 4.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  30 TLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLF-SGPYLSYYR 108
Cdd:cd15139   71 TLVGMSPNRLVCGYFGFAMTFFSLATMLILLAMALERCLSIGHPYFYERYVSKRCGYVTIPLIYLLCALFcLFPFLGFGK 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 109 QSQLANLTVC----HPAWSAPRRRAMDICTFVFSYLLPVLV--LGLTYARTLRYLWRAVDPVAAGSGARRAKR------K 176
Cdd:cd15139  151 YVQYCPGTWCfidmNPEASEHRAYANLYATLLLLLIVAVVLcnASVIYHLVRMYRRRKRNRSSVGGRARSHRRrfsmaeE 230
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767996348 177 VTRMILIV--AALFCLCWMPhhaLILCVWFGQFPLTRA----TYALRILShlvsyANSCVNPIVYALVS 239
Cdd:cd15139  231 VEHLILLVfmTIIFVICSLP---LTIQVYMNTFSDSENhkwdLIALRFLS-----VNPIIDPWVFIILS 291
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
34-246 5.18e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 41.47  E-value: 5.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYL----SYYRQ 109
Cdd:cd15217   67 WTYSVLSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVfdvgTYKFI 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 110 SQLANLTVCHPAWSAPRrramdicTFVFSYLLPVLVLG--LTYARTL--RYLWRAVDPV----------------AAGSG 169
Cdd:cd15217  147 REEDQCIFEHRYFKAND-------TLGFMLMLAVLIVAthIVYGKLLlfEYRHRKMKPVqmvpaisqnwtfhgpgATGQA 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 170 A---------------------------RR--------AKRKVTRMILIVAALFCLCWMPHhaLILCVWfgQFPLTRATY 214
Cdd:cd15217  220 AanwiagfgrgpmpptllgirqnahtanRRllgmeefkAEKRLGRMFYVITLSFLVLWSPY--IVACYW--RVFVKACSI 295
                        250       260       270
                 ....*....|....*....|....*....|....
gi 767996348 215 ALRILSHLV--SYANSCVNPIVYALVSKHFRKGF 246
Cdd:cd15217  296 PHRYLSTAVwmSFAQAGVNPIVCFLLNKDLKKCL 329
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
56-100 7.00e-04

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 40.67  E-value: 7.00e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767996348  56 SFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS 100
Cdd:cd15235   89 SFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHS 133
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
47-244 2.72e-03

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 38.72  E-value: 2.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  47 LIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSG-PYLSYYRQSQLANLTVCHPAWSAp 125
Cdd:cd15960   75 LLLAAFSASVCSLLAITVDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLlPAMGWNCLRAPASCSVLRPVTKN- 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 126 rrramDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVA------AGSGARRAKRKVTRMILIVAAlFCLCWMPhHALI 199
Cdd:cd15960  154 -----NAAVLAVSFLLLFALMMQLYLQICRIAFRHAQQIAvqhqfvNFCLASSTRKGVSTLSLILAT-FAFCWVP-FAVY 226
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 767996348 200 LCVWFGQFPLTRaTYALRilshLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15960  227 SMVADSSYPMIY-TYYLV----LPAACNSVINPIIYAFRNPDIQK 266
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
41-100 3.27e-03

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 38.73  E-value: 3.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS 100
Cdd:cd15229   73 CIAQIFFFFFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYA 132
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
41-121 3.70e-03

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 38.55  E-value: 3.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRnALAAIGL-IWGLSLLFSGPYLsyyrqSQLANLTVCH 119
Cdd:cd15950   73 CFTQMFFVHSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQ-VIAQIGLaIVLRALLFMTPLT-----CLVTSLPYCG 146

                 ..
gi 767996348 120 PA 121
Cdd:cd15950  147 SR 148
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
34-246 5.43e-03

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 37.91  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  34 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRY-LAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQL 112
Cdd:cd15127   66 WLLGDFSCKIVPYIEVASLGVTTFTLCALCIDRFrAATNVQMYYEMIENCTSTTAKLAVIWVGALLLALPEVVLRQLSKE 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 113 ANltvchPAWSAPRRRamdiCTFVFSYLLP--VLVLGLTY--ARTLRY---------LWRAVDPVAAGSGARRAKRKVTR 179
Cdd:cd15127  146 DG-----GSGAPPAER----CVVKISTELPdtIYVLALTYdgARLWWYfgcyfclptLFTITCSLVTARKIRRAEKACTR 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 180 --------------MILIVAALFCLCWMPHHALILCVWFGQFPLTRATY-ALRILSHLVSYANSCVNPIVYALVSKHFRK 244
Cdd:cd15127  217 gnkrqiqlesqmncTVVALTILYGFCIIPENICNIVTAYMATGVSRQTMdLLHLISQFLLFFKSCVTPVLLFCLCRPFSR 296

                 ..
gi 767996348 245 GF 246
Cdd:cd15127  297 AF 298
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
59-238 5.47e-03

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 37.80  E-value: 5.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  59 LAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS--GPYLSYYRQSQLANLTVChpawsaprrRAMDICTFV 136
Cdd:cd15105   89 LSAISTERCLSVLCPIWYRCRRPEHTSTVMCAVIWVLSLLICilNRYFCGFLDTKYENDSVC---------LASNFFTAA 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 137 FSYLLPVLVLGLTYARTLRYLWravdpvaaGSGarraKRKVTRM---ILIVAALFCLCWMPHHAL-ILCVWFGQFpLTRA 212
Cdd:cd15105  160 YLMFLFVVLCLSSLALLARLFC--------GAG----QMKLTRLyvtIMLTVLVFLLCGLPFGIYwFLLFWIKDD-FHVL 226
                        170       180
                 ....*....|....*....|....*.
gi 767996348 213 TYALRILSHLVSYANSCVNPIVYALV 238
Cdd:cd15105  227 DYGLYLASVVLTAVNSCANPIIYFFV 252
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
59-247 7.91e-03

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 37.38  E-value: 7.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  59 LAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSG-PYLSYYrqsqlanLTVCHPAWSApRRRAMDICTFVF 137
Cdd:cd15110   92 LTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALSVLMTSlEYLMCI-------DEGFHVRNEC-RAVLIFIGILTF 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348 138 SYLLPVLVLGLT--YARTLRYLWravdpvaagsgaRRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQfpltratYA 215
Cdd:cd15110  164 LVFTPLMLISSLilFIKVRCNSQ------------RRHPGKLYIIIMLTVIFFLIFAMPMRVLLLLNYLHH-------SS 224
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767996348 216 LRILSH---LVSYANSCVNPIVYALVSKHFRKGFR 247
Cdd:cd15110  225 FLFSNPvpfLLSTVNSSINPIVYFLVGSLRRKRIK 259
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
41-75 8.34e-03

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 37.46  E-value: 8.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767996348  41 CKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLH 75
Cdd:cd15912   73 CFAQSFFYFFLGTTEFFLLAVMSFDRYVAICNPLH 107
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
46-93 9.31e-03

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 37.30  E-value: 9.31e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767996348  46 FLIFLTMHAS-SFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIW 93
Cdd:cd15913   77 FYFFFSLGTTeCFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCW 125
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
33-160 9.71e-03

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 37.30  E-value: 9.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996348  33 GWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQL 112
Cdd:cd15169   66 AWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGW 145
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767996348 113 ANLT--------------VCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRA 160
Cdd:cd15169  146 LDHSntslgintpvngspVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARS 207
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
46-100 9.98e-03

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 37.21  E-value: 9.98e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767996348  46 FLIFLTMhaSSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFS 100
Cdd:cd15918   80 FLLFGDL--DNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHS 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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