potassium voltage-gated channel subfamily H member 6 isoform X15 [Homo sapiens]
PAS domain-containing protein( domain architecture ID 13822714)
PAS domain-containing protein
List of domain hits
Name | Accession | Description | Interval | E-value | |||||||
PLN03192 super family | cl33658 | Voltage-dependent potassium channel; Provisional |
259-698 | 1.94e-36 | |||||||
Voltage-dependent potassium channel; Provisional The actual alignment was detected with superfamily member PLN03192: Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 146.94 E-value: 1.94e-36
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PAS_9 | pfam13426 | PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
38-132 | 1.30e-18 | |||||||
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). : Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 81.35 E-value: 1.30e-18
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Name | Accession | Description | Interval | E-value | |||||||
PLN03192 | PLN03192 | Voltage-dependent potassium channel; Provisional |
259-698 | 1.94e-36 | |||||||
Voltage-dependent potassium channel; Provisional Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 146.94 E-value: 1.94e-36
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Ion_trans | pfam00520 | Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ... |
258-520 | 5.24e-31 | |||||||
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 121.61 E-value: 5.24e-31
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CAP_ED | cd00038 | effector domain of the CAP family of transcription factors; members include CAP (or cAMP ... |
594-705 | 1.67e-22 | |||||||
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels Pssm-ID: 237999 [Multi-domain] Cd Length: 115 Bit Score: 93.16 E-value: 1.67e-22
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PAS_9 | pfam13426 | PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
38-132 | 1.30e-18 | |||||||
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 81.35 E-value: 1.30e-18
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cNMP | smart00100 | Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ... |
595-694 | 1.36e-18 | |||||||
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases. Pssm-ID: 197516 [Multi-domain] Cd Length: 120 Bit Score: 82.06 E-value: 1.36e-18
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PRK13559 | PRK13559 | hypothetical protein; Provisional |
31-125 | 1.22e-15 | |||||||
hypothetical protein; Provisional Pssm-ID: 237427 [Multi-domain] Cd Length: 361 Bit Score: 79.09 E-value: 1.22e-15
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Crp | COG0664 | cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ... |
603-705 | 3.23e-15 | |||||||
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Pssm-ID: 440428 [Multi-domain] Cd Length: 207 Bit Score: 75.02 E-value: 3.23e-15
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PAS | COG2202 | PAS domain [Signal transduction mechanisms]; |
41-131 | 1.20e-13 | |||||||
PAS domain [Signal transduction mechanisms]; Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 71.59 E-value: 1.20e-13
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PAS | cd00130 | PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
41-132 | 2.81e-08 | |||||||
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction. Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 52.25 E-value: 2.81e-08
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PAS | smart00091 | PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
37-63 | 4.80e-03 | |||||||
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. Pssm-ID: 214512 Cd Length: 67 Bit Score: 36.22 E-value: 4.80e-03
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Name | Accession | Description | Interval | E-value | |||||||
PLN03192 | PLN03192 | Voltage-dependent potassium channel; Provisional |
259-698 | 1.94e-36 | |||||||
Voltage-dependent potassium channel; Provisional Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 146.94 E-value: 1.94e-36
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Ion_trans | pfam00520 | Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ... |
258-520 | 5.24e-31 | |||||||
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 121.61 E-value: 5.24e-31
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CAP_ED | cd00038 | effector domain of the CAP family of transcription factors; members include CAP (or cAMP ... |
594-705 | 1.67e-22 | |||||||
effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels Pssm-ID: 237999 [Multi-domain] Cd Length: 115 Bit Score: 93.16 E-value: 1.67e-22
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PAS_9 | pfam13426 | PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
38-132 | 1.30e-18 | |||||||
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 81.35 E-value: 1.30e-18
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cNMP | smart00100 | Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ... |
595-694 | 1.36e-18 | |||||||
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases. Pssm-ID: 197516 [Multi-domain] Cd Length: 120 Bit Score: 82.06 E-value: 1.36e-18
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PRK13559 | PRK13559 | hypothetical protein; Provisional |
31-125 | 1.22e-15 | |||||||
hypothetical protein; Provisional Pssm-ID: 237427 [Multi-domain] Cd Length: 361 Bit Score: 79.09 E-value: 1.22e-15
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PRK13558 | PRK13558 | bacterio-opsin activator; Provisional |
31-149 | 2.96e-15 | |||||||
bacterio-opsin activator; Provisional Pssm-ID: 237426 [Multi-domain] Cd Length: 665 Bit Score: 79.50 E-value: 2.96e-15
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Crp | COG0664 | cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ... |
603-705 | 3.23e-15 | |||||||
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Pssm-ID: 440428 [Multi-domain] Cd Length: 207 Bit Score: 75.02 E-value: 3.23e-15
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PAS | COG2202 | PAS domain [Signal transduction mechanisms]; |
41-131 | 1.20e-13 | |||||||
PAS domain [Signal transduction mechanisms]; Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 71.59 E-value: 1.20e-13
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cNMP_binding | pfam00027 | Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ... |
614-697 | 5.46e-13 | |||||||
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 459637 [Multi-domain] Cd Length: 89 Bit Score: 64.94 E-value: 5.46e-13
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PRK13557 | PRK13557 | histidine kinase; Provisional |
41-125 | 9.02e-11 | |||||||
histidine kinase; Provisional Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 65.08 E-value: 9.02e-11
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Ion_trans_2 | pfam07885 | Ion channel; This family includes the two membrane helix type ion channels found in bacteria. |
463-517 | 2.70e-09 | |||||||
Ion channel; This family includes the two membrane helix type ion channels found in bacteria. Pssm-ID: 462301 [Multi-domain] Cd Length: 78 Bit Score: 54.20 E-value: 2.70e-09
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PRK11753 | PRK11753 | cAMP-activated global transcriptional regulator CRP; |
616-698 | 4.16e-09 | |||||||
cAMP-activated global transcriptional regulator CRP; Pssm-ID: 236969 [Multi-domain] Cd Length: 211 Bit Score: 57.30 E-value: 4.16e-09
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PAS | pfam00989 | PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
41-131 | 6.33e-09 | |||||||
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 54.35 E-value: 6.33e-09
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PAS | cd00130 | PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
41-132 | 2.81e-08 | |||||||
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction. Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 52.25 E-value: 2.81e-08
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NtrB | COG3852 | Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
37-136 | 4.70e-06 | |||||||
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 49.46 E-value: 4.70e-06
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PRK11359 | PRK11359 | cyclic-di-GMP phosphodiesterase; Provisional |
37-146 | 7.25e-05 | |||||||
cyclic-di-GMP phosphodiesterase; Provisional Pssm-ID: 183097 [Multi-domain] Cd Length: 799 Bit Score: 46.30 E-value: 7.25e-05
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RocR | COG3829 | RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
41-135 | 2.36e-04 | |||||||
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms]; Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 44.38 E-value: 2.36e-04
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PRK10537 | PRK10537 | voltage-gated potassium channel protein; |
464-536 | 2.88e-04 | |||||||
voltage-gated potassium channel protein; Pssm-ID: 236711 [Multi-domain] Cd Length: 393 Bit Score: 43.86 E-value: 2.88e-04
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PLN02868 | PLN02868 | acyl-CoA thioesterase family protein |
588-709 | 7.69e-04 | |||||||
acyl-CoA thioesterase family protein Pssm-ID: 178459 [Multi-domain] Cd Length: 413 Bit Score: 42.40 E-value: 7.69e-04
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PAS | COG2202 | PAS domain [Signal transduction mechanisms]; |
41-132 | 3.24e-03 | |||||||
PAS domain [Signal transduction mechanisms]; Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 40.01 E-value: 3.24e-03
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PAS | smart00091 | PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
37-63 | 4.80e-03 | |||||||
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. Pssm-ID: 214512 Cd Length: 67 Bit Score: 36.22 E-value: 4.80e-03
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KinE | COG5809 | Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
19-132 | 5.00e-03 | |||||||
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]; Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 39.96 E-value: 5.00e-03
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Blast search parameters | ||||
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