|
Name |
Accession |
Description |
Interval |
E-value |
| SpoU-like_MRM1 |
cd18105 |
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ... |
146-296 |
5.98e-76 |
|
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349978 Cd Length: 158 Bit Score: 230.10 E-value: 5.98e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 146 LWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTV 225
Cdd:cd18105 1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKENGWKVVGTS 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767995964 226 GCPSTEDPQSSeIPIMSCLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTILPRRQLP-PGLESLNVSVAA 296
Cdd:cd18105 81 APPSASSDKKT-IPANELSELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGRSAEnPGVDSLNVSVAA 151
|
|
| SpoU |
COG0566 |
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ... |
51-296 |
2.02e-58 |
|
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440332 [Multi-domain] Cd Length: 265 Bit Score: 188.87 E-value: 2.02e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 51 LLFGMTPCLLALqAARRSVARLLLQAGkagLQGKRAELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSPLRPRP 130
Cdd:COG0566 28 LAEGRHAVEEAL-KAGREIEELLVTEG---ALDRLAELLALAKAAGIPVYEVSREVLDKLSGTETHQGVLAVVRPPEYAD 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 131 WREAGEASPGDDpqqLWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGF 210
Cdd:COG0566 104 LEDLLAEAGEPP---LLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNPKVVRASAGALFHVPVARVTNLADA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 211 LQTKAQQGWLVAGTvgcpsteDPQSSEipimSCLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlPrrqLPPGLESL 290
Cdd:COG0566 181 LEELKEAGFWVVGT-------DLDGEA----SLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRI-P---MAGGVESL 245
|
....*.
gi 767995964 291 NVSVAA 296
Cdd:COG0566 246 NVAVAA 251
|
|
| rRNA_methyl_3 |
TIGR00186 |
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ... |
78-296 |
8.61e-41 |
|
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 129290 [Multi-domain] Cd Length: 237 Bit Score: 142.48 E-value: 8.61e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 78 KAGLQGKRAELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSPLRPRPWREAGEASPgDDPQQLWLVLDGIQDPR 157
Cdd:TIGR00186 24 KGLESKRLKKLIQLAKKQGINIQLVDRQKLDQLTKGGNHQGIAAKVKPILYKDLNDLYKTAK-SKKQPFLLILDEITDPH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 158 NFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTVGCPSTEDPQSSE 237
Cdd:TIGR00186 103 NLGAILRTAEAFGVDGVILPKRRSAPLNSTVVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDAQDTLYQVKL 182
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 767995964 238 IpimscleflweRPTLLVLGNEGSGLSQEVQASCQLLLTILPRRQLPpgleSLNVSVAA 296
Cdd:TIGR00186 183 T-----------KPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVD----SLNVSVAA 226
|
|
| SpoU_methylase |
pfam00588 |
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet. |
148-296 |
6.20e-33 |
|
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
Pssm-ID: 425768 Cd Length: 142 Bit Score: 118.79 E-value: 6.20e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 148 LVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSC-PLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTvg 226
Cdd:pfam00588 4 VVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSAdPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVAT-- 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 227 cpsteDPQSSEIPimsclEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlPrrqLPPGLESLNVSVAA 296
Cdd:pfam00588 82 -----SLGGKSLY-----EIDFPKKVALVFGNEGTGLSNEVLELCDRLVRI-P---MSGDVESLNVAVAA 137
|
|
| PRK11181 |
PRK11181 |
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB; |
88-295 |
3.39e-23 |
|
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
Pssm-ID: 183021 [Multi-domain] Cd Length: 244 Bit Score: 96.19 E-value: 3.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 88 LLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSPLRPRPWRE-----AGEASPgddpqqLWLVLDGIQDPRNFGAV 162
Cdd:PRK11181 39 LINELEAQGIVIQLANRQTLDEKAEGAVHQGIIARVKPGRQLQENDlpdllASLEQP------FLLILDGVTDPHNLGAC 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 163 LRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTVGcPSTEDPQSSEIpims 242
Cdd:PRK11181 113 LRSADAAGVHAVIVPKDRSAQLNATAKKVACGAAETVPLIRVTNLARTMRMLQEKNIWIVGTAG-EADHTLYQSKL---- 187
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 767995964 243 cleflwERPTLLVLGNEGSGLSQEVQASCQLLLTIlPrrqLPPGLESLNVSVA 295
Cdd:PRK11181 188 ------TGPLALVMGAEGEGMRRLTREHCDELISI-P---MAGSVSSLNVSVA 230
|
|
| SpoU_sub_bind |
pfam08032 |
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ... |
51-127 |
1.47e-14 |
|
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.
Pssm-ID: 429793 [Multi-domain] Cd Length: 74 Bit Score: 67.65 E-value: 1.47e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767995964 51 LLFGMTPCLLALQAaRRSVARLLLQAGKAGLQGKraELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSPLR 127
Cdd:pfam08032 1 LIYGRHAVLEALKS-GPEIKKLYLTEGRRDPRLK--ELLKLAKERGIKVEEVDRKKLDKLSGTANHQGVVAEVKPYE 74
|
|
| SpoU_sub_bind |
smart00967 |
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ... |
57-125 |
4.49e-09 |
|
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.
Pssm-ID: 214943 [Multi-domain] Cd Length: 70 Bit Score: 52.15 E-value: 4.49e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995964 57 PCLLALQAARRsVARLLLQAGkagLQGKRAELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSP 125
Cdd:smart00967 6 AVEEALKSGRR-IKELYLTEG---RAERLKELLKLAKERGIKVIEVSKKELDKLSGTANHQGVVAVVKP 70
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SpoU-like_MRM1 |
cd18105 |
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ... |
146-296 |
5.98e-76 |
|
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349978 Cd Length: 158 Bit Score: 230.10 E-value: 5.98e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 146 LWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTV 225
Cdd:cd18105 1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKENGWKVVGTS 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767995964 226 GCPSTEDPQSSeIPIMSCLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTILPRRQLP-PGLESLNVSVAA 296
Cdd:cd18105 81 APPSASSDKKT-IPANELSELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGRSAEnPGVDSLNVSVAA 151
|
|
| SpoU |
COG0566 |
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ... |
51-296 |
2.02e-58 |
|
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440332 [Multi-domain] Cd Length: 265 Bit Score: 188.87 E-value: 2.02e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 51 LLFGMTPCLLALqAARRSVARLLLQAGkagLQGKRAELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSPLRPRP 130
Cdd:COG0566 28 LAEGRHAVEEAL-KAGREIEELLVTEG---ALDRLAELLALAKAAGIPVYEVSREVLDKLSGTETHQGVLAVVRPPEYAD 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 131 WREAGEASPGDDpqqLWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGF 210
Cdd:COG0566 104 LEDLLAEAGEPP---LLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNPKVVRASAGALFHVPVARVTNLADA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 211 LQTKAQQGWLVAGTvgcpsteDPQSSEipimSCLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlPrrqLPPGLESL 290
Cdd:COG0566 181 LEELKEAGFWVVGT-------DLDGEA----SLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRI-P---MAGGVESL 245
|
....*.
gi 767995964 291 NVSVAA 296
Cdd:COG0566 246 NVAVAA 251
|
|
| SpoU-like_RlmB |
cd18103 |
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ... |
146-296 |
9.22e-42 |
|
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349976 Cd Length: 143 Bit Score: 141.75 E-value: 9.22e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 146 LWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTV 225
Cdd:cd18103 1 LLLILDGITDPHNLGAIIRSAEAFGVDGVIIPKRRSAPLTPTVAKASAGALEHLPIARVTNLARALEELKEAGFWIYGAD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767995964 226 GcpstedpqSSEIPImscLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlPrrqLPPGLESLNVSVAA 296
Cdd:cd18103 81 G--------EAEKSL---YDVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKI-P---MAGKVDSLNVSVAA 136
|
|
| SpoU-like_rRNA-MTase |
cd18095 |
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ... |
146-296 |
4.14e-41 |
|
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349968 Cd Length: 143 Bit Score: 140.25 E-value: 4.14e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 146 LWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTV 225
Cdd:cd18095 1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVDPYNPKVVRASMGALFRLPIIRVDDLEELLEELKEAGYKVVAAD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767995964 226 GCPSTedpqsseipimSCLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlPrrqLPPGLESLNVSVAA 296
Cdd:cd18095 81 LDGGS-----------SLYDLDLPKPVALVLGNEGNGLSDELLELCDKRVTI-P---MSGGVESLNVAVAA 136
|
|
| rRNA_methyl_3 |
TIGR00186 |
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ... |
78-296 |
8.61e-41 |
|
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]
Pssm-ID: 129290 [Multi-domain] Cd Length: 237 Bit Score: 142.48 E-value: 8.61e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 78 KAGLQGKRAELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSPLRPRPWREAGEASPgDDPQQLWLVLDGIQDPR 157
Cdd:TIGR00186 24 KGLESKRLKKLIQLAKKQGINIQLVDRQKLDQLTKGGNHQGIAAKVKPILYKDLNDLYKTAK-SKKQPFLLILDEITDPH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 158 NFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTVGCPSTEDPQSSE 237
Cdd:TIGR00186 103 NLGAILRTAEAFGVDGVILPKRRSAPLNSTVVKTSSGAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDAQDTLYQVKL 182
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 767995964 238 IpimscleflweRPTLLVLGNEGSGLSQEVQASCQLLLTILPRRQLPpgleSLNVSVAA 296
Cdd:TIGR00186 183 T-----------KPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVD----SLNVSVAA 226
|
|
| SpoU_methylase |
pfam00588 |
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet. |
148-296 |
6.20e-33 |
|
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
Pssm-ID: 425768 Cd Length: 142 Bit Score: 118.79 E-value: 6.20e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 148 LVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSC-PLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTvg 226
Cdd:pfam00588 4 VVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSAdPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVAT-- 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 227 cpsteDPQSSEIPimsclEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlPrrqLPPGLESLNVSVAA 296
Cdd:pfam00588 82 -----SLGGKSLY-----EIDFPKKVALVFGNEGTGLSNEVLELCDRLVRI-P---MSGDVESLNVAVAA 137
|
|
| PRK11181 |
PRK11181 |
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB; |
88-295 |
3.39e-23 |
|
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
Pssm-ID: 183021 [Multi-domain] Cd Length: 244 Bit Score: 96.19 E-value: 3.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 88 LLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSPLRPRPWRE-----AGEASPgddpqqLWLVLDGIQDPRNFGAV 162
Cdd:PRK11181 39 LINELEAQGIVIQLANRQTLDEKAEGAVHQGIIARVKPGRQLQENDlpdllASLEQP------FLLILDGVTDPHNLGAC 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 163 LRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTVGcPSTEDPQSSEIpims 242
Cdd:PRK11181 113 LRSADAAGVHAVIVPKDRSAQLNATAKKVACGAAETVPLIRVTNLARTMRMLQEKNIWIVGTAG-EADHTLYQSKL---- 187
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 767995964 243 cleflwERPTLLVLGNEGSGLSQEVQASCQLLLTIlPrrqLPPGLESLNVSVA 295
Cdd:PRK11181 188 ------TGPLALVMGAEGEGMRRLTREHCDELISI-P---MAGSVSSLNVSVA 230
|
|
| SpoU-like_TrmH |
cd18092 |
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ... |
148-306 |
3.62e-19 |
|
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349965 Cd Length: 162 Bit Score: 82.90 E-value: 3.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 148 LVLDGIQDPRNFGAVLRSAHFLGVDKV-ITSRRNScplTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTvg 226
Cdd:cd18092 19 VVLENVHDPHNASAVLRTCDAFGVQDVhVIEPKNK---FKKNRGVAMGADKWLDVHRHDSTEECLAALKEQGYRIVAT-- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 227 cpsteDPQSSEIPIMsclEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlprrqlpP--GL-ESLNVSVAAELgTLNE 303
Cdd:cd18092 94 -----SLSPDAVPLD---ELDYTRPTALVFGNEKDGVSEEALAAADERVYI-------PmyGFvESLNVSVAAAI-ILYE 157
|
...
gi 767995964 304 ITH 306
Cdd:cd18092 158 LQR 160
|
|
| SpoU-like_family |
cd18082 |
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ... |
148-296 |
6.47e-18 |
|
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349955 Cd Length: 145 Bit Score: 79.19 E-value: 6.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 148 LVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQT-KAQQGWLVA---G 223
Cdd:cd18082 2 LVLDNIRSPGNIGSIFRTADAFGVEKIYLVGPTADIFDPKAKRTSRGTHFSVPYERVDNFEEYLKSlKEEGYPLIGlelT 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767995964 224 TVGCPSTEdpqsseipimscLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlPRRqlpPGLESLNVSVAA 296
Cdd:cd18082 82 DGSIPLSE------------FKFKKPKKIALIFGNERSGLSPELLALCDYTVHI-PMS---GKNSSLNVSVAT 138
|
|
| SpoU-like_RNA-MTase |
cd18109 |
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ... |
148-296 |
3.12e-17 |
|
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349982 Cd Length: 141 Bit Score: 77.19 E-value: 3.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 148 LVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQtkAQQGWLVAGTvgc 227
Cdd:cd18109 3 LALDGIQDPGNLGTIIRTADWFGIRQIICSPDTVDPYNPKVVQASMGSIFRVQIHYTDLPALLAE--LKKAFPVYGA--- 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995964 228 psteDPQSSEIpimscLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlPRRqlPPGLESLNVSVAA 296
Cdd:cd18109 78 ----DLDGENL-----YEFTLPEKGILVMGNEGHGISPEVLKLLTHRLTI-PRY--GKGAESLNVAVAT 134
|
|
| SpoU-like |
cd18097 |
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ... |
146-296 |
3.08e-16 |
|
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349970 Cd Length: 144 Bit Score: 74.52 E-value: 3.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 146 LWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTV 225
Cdd:cd18097 1 LVVVLDNLRSAHNVGSIFRTADAAGVEKIYLCGYTPTPPHPKVAKTALGAEESVPWEHFEDTLEAVRALKARGYTIIALE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767995964 226 GCPSTEDPQsseipimsclEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlPRRqlppGLE-SLNVSVAA 296
Cdd:cd18097 81 TTENSVPLH----------EARLPRPLALVLGNEVRGVSPEVLALCDAVVEI-PMF----GRKnSLNVAVAA 137
|
|
| SpoU_sub_bind |
pfam08032 |
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ... |
51-127 |
1.47e-14 |
|
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.
Pssm-ID: 429793 [Multi-domain] Cd Length: 74 Bit Score: 67.65 E-value: 1.47e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767995964 51 LLFGMTPCLLALQAaRRSVARLLLQAGKAGLQGKraELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSPLR 127
Cdd:pfam08032 1 LIYGRHAVLEALKS-GPEIKKLYLTEGRRDPRLK--ELLKLAKERGIKVEEVDRKKLDKLSGTANHQGVVAEVKPYE 74
|
|
| SpoU-like |
cd18096 |
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ... |
146-296 |
1.32e-13 |
|
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349969 Cd Length: 140 Bit Score: 66.86 E-value: 1.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 146 LWLVLDGIQDPRNFGAVLRSAHFLGVDKV-ITSRRnscPLTPVVSKSSAGAMEVMDVFSTDDLTGFLqtkAQQGWLVagt 224
Cdd:cd18096 1 LYLVLHNVAKRHNIGTIVRSANAFGVKEVhLVGRR---KFNPFGAMGTDRHVKFRHFDTLAEAKEYL---KERGIRL--- 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767995964 225 VGCPSTEDPQSSEipimsclEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlprRQLPPGLESLNVSVAA 296
Cdd:cd18096 72 VGVEIVPGAEPIE-------THPFPGDTAFVLGNEGTGLSDEQLAICDGFVYI---PQYGSGTASLNVSVAA 133
|
|
| SpoU-like_AviRb |
cd18107 |
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ... |
146-296 |
1.38e-09 |
|
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349980 Cd Length: 148 Bit Score: 55.86 E-value: 1.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 146 LWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAG---AMEVMDVFSTDDLTGFLQT--KAQQGWL 220
Cdd:cd18107 1 LVVLFDRPTSPGNLGTIIRSADALGAHGLVVTGHAADVYDPKTIRASTGslfSLPIVRVPSNRELEDWVEArkARGTPLQ 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767995964 221 VAGTvgcpstedpqsSEIPIMSCLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTIlprrQLPPGLESLNVSVAA 296
Cdd:cd18107 81 LVGT-----------DEHGDHQIADHDFTRPTLLLIGNETAGLSAAWRELCDETVSI----PMAGSASSLNAACAA 141
|
|
| PRK10864 |
PRK10864 |
putative methyltransferase; Provisional |
116-296 |
3.95e-09 |
|
putative methyltransferase; Provisional
Pssm-ID: 236779 [Multi-domain] Cd Length: 346 Bit Score: 57.10 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 116 HQGVCMEVsplRPRPWREAGEASPGDDPQQLWLVLDGIQDPRNFGAVLRS-AHFlGVDKVITSrrnscplTPVVSKSSA- 193
Cdd:PRK10864 172 HGGVCFLI---KKRNGTDVQQWLAQAGAQDCVLALEDVGNPHNLGGIMRScAHF-GVKGVVVQ-------DAALLESGAa 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 194 -----GAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTVGCPSTEDPQsSEIPimscleflweRPTLLVLGNEGSGLSQEVQ 268
Cdd:PRK10864 241 irtaeGGAEHVQPITGDSFVDVLDDFRQAGYTIVTTSSHKGTPLFK-ASLP----------AKMVLVLGQEYDGLSDAAR 309
|
170 180 190
....*....|....*....|....*....|.
gi 767995964 269 ASCQLLLTIlprrqlpPG---LESLNVSVAA 296
Cdd:PRK10864 310 QQGDLSVSI-------DGtgnVESLNVSVAT 333
|
|
| SpoU_sub_bind |
smart00967 |
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose ... |
57-125 |
4.49e-09 |
|
RNA 2'-O ribose methyltransferase substrate binding; This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.
Pssm-ID: 214943 [Multi-domain] Cd Length: 70 Bit Score: 52.15 E-value: 4.49e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767995964 57 PCLLALQAARRsVARLLLQAGkagLQGKRAELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSP 125
Cdd:smart00967 6 AVEEALKSGRR-IKELYLTEG---RAERLKELLKLAKERGIKVIEVSKKELDKLSGTANHQGVVAVVKP 70
|
|
| SpoU-like_RNMTL1 |
cd18106 |
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ... |
148-296 |
5.56e-08 |
|
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349979 Cd Length: 148 Bit Score: 51.10 E-value: 5.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 148 LVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGA---MEVMDVFSTDDLTGFLQTKAQqgWLVAgt 224
Cdd:cd18106 3 VICDNIRDPGNLGSILRSAAAAGCSKVLLTKGCVDPWEPKVLRAGAGAhfrLPIYGNLSWDDIPNYLPDDSK--VFLA-- 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767995964 225 vgcpstedpqSSEIPIMSCLEFLWER-PTLLVLGNEGSGLSQEVQASCQLL----LTIlPrrqLPPGLESLNVSVAA 296
Cdd:cd18106 79 ----------DNNLPVQPYDSIDYCSgPIVLVIGGETHGVSPEAYKLAHSTggsrVHI-P---LANGVDSLNSAVAA 141
|
|
| SpoU-like_TRM3-like |
cd18091 |
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ... |
153-296 |
1.07e-06 |
|
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.
Pssm-ID: 349964 Cd Length: 145 Bit Score: 47.53 E-value: 1.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 153 IQDPRNFGAVLRSAHFLGVDKVITSRRNSC--PLTPVVSKSSAGAMEVMDVfSTDDLTGFLQTKAQQGWLVAGTvgcpst 230
Cdd:cd18091 8 IDKPPNLGGLCRTCEIFGVSKLVLPNLAVVedKQFKALSVSAEKWLPIEEV-KPEDLLPYLKEKKQEGYTIVGL------ 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 231 EdpQSSEIPIMSclEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTI----LPRrqlppgleSLNVSVAA 296
Cdd:cd18091 81 E--QTANSVSLH--DFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEIpqlgVIR--------SLNVHVSG 138
|
|
| SpoU-like_NHR |
cd18108 |
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) ... |
148-296 |
9.91e-03 |
|
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) confers resistance to the thiazole antibiotic nosiheptide via catalyzing 2'O-methylation of 23S rRNA at the nucleotide A1067. NHR is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Pssm-ID: 349981 Cd Length: 144 Bit Score: 35.92 E-value: 9.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995964 148 LVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNscpLTPV----VSKSSAGAMEVMDVFSTD--DLTGFLQTKAQQGWLV 221
Cdd:cd18108 3 VVLDGVRIVGNIGAIVRTSLALGAAGIVLVDSD---LATVadrrLLRASRGYVFSLPVVLADreEAVAFLRDNDIPLMTL 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767995964 222 A--GTVGCPSTEDPQSseipimscleflwerPTLLVLGNEGSGLSQEVQASCQLLLTIlprrQLPPGLESLNVSVAA 296
Cdd:cd18108 80 DadGDVPVKELGDRPD---------------RLALVFGSEKGGPSGLFEEAAAGTVSI----PMSSSTESLNVSVSA 137
|
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