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Conserved domains on  [gi|767984076|ref|XP_011519844|]
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zinc finger protein 710 isoform X3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
335-593 4.52e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 4.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 335 PSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFA--YPSELKAHEVKHESgrCHVCVEC 412
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksLLSQSPSSLSSSDS--SSSASES 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 413 -----GLDFSTLTQLKRHL-ASHQGPTL-YQCLECDKSFHYRSQLQNHMLKH----QNVRPFVCTE--CGMEFSQIHHLK 479
Cdd:COG5048  261 prsslPTASSQSSSPNESDsSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCPYslCGKLFSRNDALK 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 480 QHSLTHKGVKEFKC--EVCGREFTLQANMKRHMLIHTSV-----RPYQC--HICFKTFVQKQTLKTHMIVHSPVKP--FK 548
Cdd:COG5048  341 RHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767984076 549 CKVCGKSFNRMYNLLGHMHLHAGSKPFkCPYCSSKFNLKGNLSRH 593
Cdd:COG5048  421 NPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
335-593 4.52e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 4.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 335 PSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFA--YPSELKAHEVKHESgrCHVCVEC 412
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksLLSQSPSSLSSSDS--SSSASES 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 413 -----GLDFSTLTQLKRHL-ASHQGPTL-YQCLECDKSFHYRSQLQNHMLKH----QNVRPFVCTE--CGMEFSQIHHLK 479
Cdd:COG5048  261 prsslPTASSQSSSPNESDsSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCPYslCGKLFSRNDALK 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 480 QHSLTHKGVKEFKC--EVCGREFTLQANMKRHMLIHTSV-----RPYQC--HICFKTFVQKQTLKTHMIVHSPVKP--FK 548
Cdd:COG5048  341 RHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767984076 549 CKVCGKSFNRMYNLLGHMHLHAGSKPFkCPYCSSKFNLKGNLSRH 593
Cdd:COG5048  421 NPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
534-558 2.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.91e-04
                          10        20
                  ....*....|....*....|....*
gi 767984076  534 LKTHMIVHSPVKPFKCKVCGKSFNR 558
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 423-510 3.45e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 3.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 423 KRHLASHQGPTLYQCLECDKSFH------------------YRSQLQNH------MLKHQNVRPFVCTECGMEFSQIHHL 478
Cdd:PHA00733  10 KKYLSNHKGIFIHVTLEELKRYHsltpeqkrliravvktliYNPQLLDEssylykLLTSKAVSPYVCPLCLMPFSSSVSL 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767984076 479 KQHSLTHKGVKefKCEVCGREFTLQANMKRHM 510
Cdd:PHA00733  90 KQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
335-593 4.52e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 4.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 335 PSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFA--YPSELKAHEVKHESgrCHVCVEC 412
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksLLSQSPSSLSSSDS--SSSASES 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 413 -----GLDFSTLTQLKRHL-ASHQGPTL-YQCLECDKSFHYRSQLQNHMLKH----QNVRPFVCTE--CGMEFSQIHHLK 479
Cdd:COG5048  261 prsslPTASSQSSSPNESDsSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCPYslCGKLFSRNDALK 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 480 QHSLTHKGVKEFKC--EVCGREFTLQANMKRHMLIHTSV-----RPYQC--HICFKTFVQKQTLKTHMIVHSPVKP--FK 548
Cdd:COG5048  341 RHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767984076 549 CKVCGKSFNRMYNLLGHMHLHAGSKPFkCPYCSSKFNLKGNLSRH 593
Cdd:COG5048  421 NPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
425-595 3.68e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 3.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 425 HLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVR-PFVCTECGMEFSQIHHLKQH----SLTHKGVKEFKC--EVCG 497
Cdd:COG5048  251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHlrsvNHSGESLKPFSCpySLCG 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 498 REFTLQANMKRHMLIHTSVRPYQCHIC--------------FKTFVQKQTLKtHMIVHSPVKPFKCKVCGKSFNRMYNLl 563
Cdd:COG5048  331 KLFSRNDALKRHILLHTSISPAKEKLLnssskfspllnnepPQSLQQYKDLK-NDKKSETLSNSCIRNFKRDSNLSLHI- 408

                        170       180       190
                 ....*....|....*....|....*....|..
gi 767984076 564 gHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMK 595
Cdd:COG5048  409 -ITHLSFRPYNCKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-589 4.27e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 4.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 300 CEKSYTSKYNLVTHILGHNGIKPHSCPH--CSKLFKQPSHLQTHLLTHQGTRPHKC-QVCHKAFTQTSHLKRHMLLHSEV 376
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 377 KPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLD-------FSTLTQLKRHLASHQGPTLYQCLEC-DKSFHYRS 448
Cdd:COG5048  119 DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKDPSSNLSLLISsNVSTSIPS 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 449 QLQNHMLKHQNVRPFVCTECGMEFSQIH--------HLKQHSLTHKGVKEFK------CEVCGREFTLQANMKRHMLIHT 514
Cdd:COG5048  199 SSENSPLSSSYSIPSSSSDQNLENSSSSlplttnsqLSPKSLLSQSPSSLSSsdssssASESPRSSLPTASSQSSSPNES 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 515 SVR-------PYQCHICFKTFVQKQTLKTHM--IVHS--PVKPFKCKV--CGKSFNRMYNLLGHMHLHAGSKPFKCPY-- 579
Cdd:COG5048  279 DSSsekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLln 358

                        330
                 ....*....|
gi 767984076 580 CSSKFNLKGN 589
Cdd:COG5048  359 SSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-537 7.32e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 7.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 303 SYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEV------ 376
Cdd:COG5048  207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgf 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 377 -KPYSCHFCGRGFAYPSELKAH--EVKH--ESGRCHVCVE--CGLDFSTLTQLKRHLASHQGPTLYQCLECD-------K 442
Cdd:COG5048  287 sLPIKSKQCNISFSRSSPLTRHlrSVNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspL 366

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 443 SFHYRSQLQNHMLKHQNVRPFVCT--ECGMEFSQIHHLKQHSLTHKGVK--EFKCEVCGREFTLQANMKRHMLIHTSVRP 518
Cdd:COG5048  367 LNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        250
                 ....*....|....*....
gi 767984076 519 YQCHICFKtFVQKQTLKTH 537
Cdd:COG5048  447 LLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
534-558 2.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.91e-04
                          10        20
                  ....*....|....*....|....*
gi 767984076  534 LKTHMIVHSPVKPFKCKVCGKSFNR 558
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-362 5.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.45e-04
                          10        20
                  ....*....|....*....|....*.
gi 767984076  337 HLQTHLLTHQGTRPHKCQVCHKAFTQ 362
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 351-373 1.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.80e-03
                          10        20
                  ....*....|....*....|...
gi 767984076  351 HKCQVCHKAFTQTSHLKRHMLLH 373
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-390 1.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.86e-03
                          10        20
                  ....*....|....*....|....*.
gi 767984076  365 HLKRHMLLHSEVKPYSCHFCGRGFAY 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 423-510 3.45e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.32  E-value: 3.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767984076 423 KRHLASHQGPTLYQCLECDKSFH------------------YRSQLQNH------MLKHQNVRPFVCTECGMEFSQIHHL 478
Cdd:PHA00733  10 KKYLSNHKGIFIHVTLEELKRYHsltpeqkrliravvktliYNPQLLDEssylykLLTSKAVSPYVCPLCLMPFSSSVSL 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767984076 479 KQHSLTHKGVKefKCEVCGREFTLQANMKRHM 510
Cdd:PHA00733  90 KQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 347-401 3.90e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767984076 347 GTRPHKCQV--CHKAFTQTSHLKRHML-------------------LHSEVKPYSCHFCGRGFAYPSELKAHeVKH 401
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYH-RKH 420
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 435-457 4.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.99e-03
                          10        20
                  ....*....|....*....|...
gi 767984076  435 YQCLECDKSFHYRSQLQNHMLKH 457
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 519-541 5.40e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.40e-03
                          10        20
                  ....*....|....*....|...
gi 767984076  519 YQCHICFKTFVQKQTLKTHMIVH 541
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-530 5.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 767984076  505 NMKRHMLIHTSVRPYQCHICFKTFVQ 530
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00616 PHA00616
hypothetical protein
 434-463 9.74e-03

hypothetical protein


Pssm-ID: 177288  Cd Length: 44  Bit Score: 34.36  E-value: 9.74e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 767984076 434 LYQCLECDKSFHYRSQLQNHMLKHQNVRPF 463
Cdd:PHA00616   1 MYQCLRCGGIFRKKKEVIEHLLSVHKQNKL 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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