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Conserved domains on  [gi|767983273|ref|XP_011519520|]
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leucine-rich repeat-containing protein 28 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-221 2.28e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.09  E-value: 2.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  38 EGLQYLERLYMKRNSLTSLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLsdnaleivcpeigrlralrhlr 117
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL---------------------- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 118 lANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPl 197
Cdd:COG4886  167 -SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                        170       180
                 ....*....|....*....|....
gi 767983273 198 DLGRSRELQYVYVDNNiHLKGLPS 221
Cdd:COG4886  245 ELGNLTNLEELDLSNN-QLTDLPP 267
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-221 2.28e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.09  E-value: 2.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  38 EGLQYLERLYMKRNSLTSLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLsdnaleivcpeigrlralrhlr 117
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL---------------------- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 118 lANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPl 197
Cdd:COG4886  167 -SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                        170       180
                 ....*....|....*....|....
gi 767983273 198 DLGRSRELQYVYVDNNiHLKGLPS 221
Cdd:COG4886  245 ELGNLTNLEELDLSNN-QLTDLPP 267
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-306 4.21e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 79.74  E-value: 4.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  46 LYMKRNSLTSLPENLAQklpNLVELYLHSNNIVVVPEAIGSLVklQCLDLSDNALeIVCPEigrlralrhlrlannqlqF 125
Cdd:PRK15370 204 LILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTI--QEMELSINRI-TELPE------------------R 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 126 LPpevgdlKELQTLDISTNRLLTLPERLHMclSLQYLTVDRNRLWYVPRHlcqLPS-LNELSMAGNRLAFLPLDLgrSRE 204
Cdd:PRK15370 260 LP------SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAH---LPSgITHLNVQSNSLTALPETL--PPG 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 205 LQYVYVDNNIhLKGLPSYLynkvigcsgcgaPiqvSEVKLLSFSSGQRTVF---LPAEVKAIGTEHDHVLPLQE---LAM 278
Cdd:PRK15370 327 LKTLEAGENA-LTSLPASL------------P---PELQVLDVSKNQITVLpetLPPTITTLDVSRNALTNLPEnlpAAL 390

                        250       260
                 ....*....|....*....|....*...
gi 767983273 279 RGLYHTYHSLLKdlnflSPISLPRSLLE 306
Cdd:PRK15370 391 QIMQASRNNLVR-----LPESLPHFRGE 413
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-190 1.60e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 1.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  38 EGLQYLERLYMKRNSLTSLpENLaQKLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEivcpeigrlralrhlr 117
Cdd:cd21340   43 EFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP---------------- 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767983273 118 lANNQLQFLPPEVGDLKE-LQTLDISTNRLLTLpERLHMCLSLQYLTVDRNRLW---YVPRHLCQLPSLNELSMAGN 190
Cdd:cd21340  104 -PGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
43-100 1.03e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.03e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767983273   43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNAL 100
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-221 2.28e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.09  E-value: 2.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  38 EGLQYLERLYMKRNSLTSLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLsdnaleivcpeigrlralrhlr 117
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDL---------------------- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 118 lANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPl 197
Cdd:COG4886  167 -SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                        170       180
                 ....*....|....*....|....
gi 767983273 198 DLGRSRELQYVYVDNNiHLKGLPS 221
Cdd:COG4886  245 ELGNLTNLEELDLSNN-QLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-169 3.59e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 3.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQYLERLYMKRNSLTSLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVK 89
Cdd:COG4886  131 ELANLTNLKELDLSNNQLTDLPEPL---GNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPEPLGNLTN 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  90 LQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPpEVGDLKELQTLDISTNRLLTLPERLHMClSLQYLTVDRNRL 169
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLT-NLKTLDLSNNQL 284
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-306 4.21e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 79.74  E-value: 4.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  46 LYMKRNSLTSLPENLAQklpNLVELYLHSNNIVVVPEAIGSLVklQCLDLSDNALeIVCPEigrlralrhlrlannqlqF 125
Cdd:PRK15370 204 LILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTI--QEMELSINRI-TELPE------------------R 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 126 LPpevgdlKELQTLDISTNRLLTLPERLHMclSLQYLTVDRNRLWYVPRHlcqLPS-LNELSMAGNRLAFLPLDLgrSRE 204
Cdd:PRK15370 260 LP------SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAH---LPSgITHLNVQSNSLTALPETL--PPG 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 205 LQYVYVDNNIhLKGLPSYLynkvigcsgcgaPiqvSEVKLLSFSSGQRTVF---LPAEVKAIGTEHDHVLPLQE---LAM 278
Cdd:PRK15370 327 LKTLEAGENA-LTSLPASL------------P---PELQVLDVSKNQITVLpetLPPTITTLDVSRNALTNLPEnlpAAL 390

                        250       260
                 ....*....|....*....|....*...
gi 767983273 279 RGLYHTYHSLLKdlnflSPISLPRSLLE 306
Cdd:PRK15370 391 QIMQASRNNLVR-----LPESLPHFRGE 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-149 1.44e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQYLERLYMKRNSLTSLPENLAQkLPNLVELYLHSNNIVVVPEAIGSLVK 89
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPEEL---GNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANLTN 229

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  90 LQCLDLSDNALEIVcPEIGRLRALRHLRLANNQLQFLPPEvGDLKELQTLDISTNRLLTL 149
Cdd:COG4886  230 LETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL 287
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-223 2.83e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.35  E-value: 2.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273   3 SELC------KTISVARLEKHKNLFLNYRNLHHFPlellkdEGLQ-YLERLYMKRNSLTSLPENlaqkLPNLVE-LYLHS 74
Cdd:PRK15370 181 TELRlkilglTTIPACIPEQITTLILDNNELKSLP------ENLQgNIKTLYANSNQLTSIPAT----LPDTIQeMELSI 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  75 NNIVVVPEAIGSlvKLQCLDLSDNALEIVcPEiGRLRALRHLRLANNQLQFLPPEVGdlKELQTLDISTNRLLTLPERLH 154
Cdd:PRK15370 251 NRITELPERLPS--ALQSLDLFHNKISCL-PE-NLPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLP 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767983273 155 MclSLQYLTVDRNRLWYVPRHLCqlPSLNELSMAGNRLAFLPLDLGRSreLQYVYVDNNIhLKGLPSYL 223
Cdd:PRK15370 325 P--GLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPPT--ITTLDVSRNA-LTNLPENL 386
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
11-176 8.74e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.73  E-value: 8.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  11 VARLEKHKNLFLNYRNLHHFPLELLKD---EGLQYLErlyMKRNSLTSLPENLAQklpNLVELYLHSNNIVVVPEAIGsl 87
Cdd:PRK15370 253 ITELPERLPSALQSLDLFHNKISCLPEnlpEELRYLS---VYDNSIRTLPAHLPS---GITHLNVQSNSLTALPETLP-- 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  88 VKLQCLDLSDNAL----EIVCPEIgrlralRHLRLANNQLQFLPPEVGdlKELQTLDISTNRLLTLPERLHMclSLQYLT 163
Cdd:PRK15370 325 PGLKTLEAGENALtslpASLPPEL------QVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPA--ALQIMQ 394

                        170
                 ....*....|...
gi 767983273 164 VDRNRLWYVPRHL 176
Cdd:PRK15370 395 ASRNNLVRLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-225 3.66e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 3.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  39 GLQYLERLYMKRNSLT-SLPENLAQKLPNLVELYLhSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCP-EIGRLRALRHL 116
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNL-SNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPnDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 117 RLANNQLQ-FLPPEVGDLKELQTLDISTNRLL-TLPERLHMCLSLQYLTVDRNRL-WYVPRHLCQLPSLNELSMAGNRLA 193
Cdd:PLN00113 170 DLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLsGEIPYEIGGLTSLNHLDLVYNNLT 249

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767983273 194 F-LPLDLGRSRELQYVYVDNNIHLKGLPSYLYN 225
Cdd:PLN00113 250 GpIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS 282
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 12-221 7.46e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 7.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  12 ARLEKHKNL---FLNYRNLH-HFPLELLKDEGLQYLERLYmkrNSLT-SLPENLAQkLPNLVELYLHSNNIV-VVPEAIG 85
Cdd:PLN00113 206 RELGQMKSLkwiYLGYNNLSgEIPYEIGGLTSLNHLDLVY---NNLTgPIPSSLGN-LKNLQYLFLYQNKLSgPIPPSIF 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  86 SLVKLQCLDLSDNALEIVCPE--IGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLL-TLPERLHMCLSLQYL 162
Cdd:PLN00113 282 SLQKLISLDLSDNSLSGEIPElvIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVL 361

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767983273 163 TVDRNRL-WYVPRHLCQLPSLNELSMAGNRL-AFLPLDLGRSRELQYVYVDNNiHLKG-LPS 221
Cdd:PLN00113 362 DLSTNNLtGEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDN-SFSGeLPS 422
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-151 1.29e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  10 SVARLEKHKNLFLNYRNLHHFPLELlkdEGLQYLERLYMKRNSLTSLPEnLAQkLPNLVELYLHSNNIVVVPEaIGSLVK 89
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDLPEPL---ANLTNLETLDLSNNQLTDLPE-LGN-LTNLEELDLSNNQLTDLPP-LANLTN 273

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767983273  90 LQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPE 151
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-225 2.46e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  74 SNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLperl 153
Cdd:COG4886   36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN---- 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767983273 154 hmCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNiHLKGLPSYLYN 225
Cdd:COG4886  112 --LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN-QLTDLPEELGN 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-190 1.60e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 1.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  38 EGLQYLERLYMKRNSLTSLpENLaQKLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEivcpeigrlralrhlr 117
Cdd:cd21340   43 EFLTNLTHLYLQNNQIEKI-ENL-ENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP---------------- 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767983273 118 lANNQLQFLPPEVGDLKE-LQTLDISTNRLLTLpERLHMCLSLQYLTVDRNRLW---YVPRHLCQLPSLNELSMAGN 190
Cdd:cd21340  104 -PGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLTGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
43-220 1.68e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.16  E-value: 1.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  43 LERLYMKRNSLTSLPenlaQKLPNLVELYLHSNNIVVVPEAIGSLVKL-----------------QCLDLSDNALEIVcP 105
Cdd:PRK15387 244 LRTLEVSGNQLTSLP----VLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlppglQELSVSDNQLASL-P 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 106 EIgrLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHmclslqyltvdrnRLWYVPRHLCQLPS---- 181
Cdd:PRK15387 319 AL--PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELY-------------KLWAYNNRLTSLPAlpsg 383

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767983273 182 LNELSMAGNRLAFLPLdlgRSRELQYVYVDNNiHLKGLP 220
Cdd:PRK15387 384 LKELIVSGNRLTSLPV---LPSELKELMVSGN-RLTSLP 418
LRR_8 pfam13855
Leucine rich repeat;
43-100 1.03e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.03e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767983273   43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSDNAL 100
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
43-193 1.10e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  43 LERLYMKRNSLTSLPenlaqKLPN-LVELYLHSNNIVVVPEAIGSLvklQCLDLSDNALEIVcPEIgrLRALRHLRLANN 121
Cdd:PRK15387 304 LQELSVSDNQLASLP-----ALPSeLCKLWAYNNQLTSLPTLPSGL---QELSVSDNQLASL-PTL--PSELYKLWAYNN 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 122 QLQFLPPEVGDLKEL-----------------QTLDISTNRLLTLPERLHMCLSLqylTVDRNRLWYVPRHLCQLPSLNE 184
Cdd:PRK15387 373 RLTSLPALPSGLKELivsgnrltslpvlpselKELMVSGNRLTSLPMLPSGLLSL---SVYRNQLTRLPESLIHLSSETT 449


                 ....*....
gi 767983273 185 LSMAGNRLA 193
Cdd:PRK15387 450 VNLEGNPLS 458
LRR_8 pfam13855
Leucine rich repeat;
18-77 1.47e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273   18 KNLFLNYRNLHHFPLELLKdeGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNI 77
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFK--GLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 125-200 8.19e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 8.19e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767983273 125 FLPPEVGDLKELQTLDISTNRLL-TLPERLHMCLSLQYLTVDRNRL-WYVPRHLCQLPSLNELSMAGNRLA-FLPLDLG 200
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
123-221 1.18e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 123 LQFLPPEvgdlkeLQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQL--------------PSLNELSMA 188
Cdd:PRK15387 237 LPALPPE------LRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLwifgnqltslpvlpPGLQELSVS 310

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767983273 189 GNRLAFLPldlGRSRELQYVYVDNNiHLKGLPS 221
Cdd:PRK15387 311 DNQLASLP---ALPSELCKLWAYNN-QLTSLPT 339
PLN03150 PLN03150
hypothetical protein; Provisional
 79-169 2.73e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  79 VVPEAIGSLVKLQCLDLSDNALEIVcpeigrlralrhlrlannqlqfLPPEVGDLKELQTLDISTNRLL-TLPERLHMCL 157
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRGN----------------------IPPSLGSITSLEVLDLSYNSFNgSIPESLGQLT 490

                         90
                 ....*....|..
gi 767983273 158 SLQYLTVDRNRL 169
Cdd:PLN03150 491 SLRILNLNGNSL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-221 2.83e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  43 LERLYMKRNSLT-SLPENLAQKlpNLVELYLHSNNIV-VVPEAIGSLVKLQCLDLSDNALEIVCPEigrlralrhlrlan 120
Cdd:PLN00113 454 LQMLSLARNKFFgGLPDSFGSK--RLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEIPD-------------- 517

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273 121 nqlqflppEVGDLKELQTLDISTNRLLTlperlhmclslqyltvdrnrlwYVPRHLCQLPSLNELSMAGNRLAF-LPLDL 199
Cdd:PLN00113 518 --------ELSSCKKLVSLDLSHNQLSG----------------------QIPASFSEMPVLSQLDLSQNQLSGeIPKNL 567

                        170       180
                 ....*....|....*....|...
gi 767983273 200 GRSRELQYVYVDNNiHLKG-LPS 221
Cdd:PLN00113 568 GNVESLVQVNISHN-HLHGsLPS 589
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-192 4.29e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273  46 LYMKRNSLTSLpENLAQkLPNLVELYLHSNNIVVVpEAIGSLVKLQCLDLSDNALEIVCPeIGRLRALRHLRLANNQLQF 125
Cdd:cd21340    7 LYLNDKNITKI-DNLSL-CKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISV 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767983273 126 LppE-VGDLKELQTLDISTNRL-----LTLPERLHMCL--SLQYLTVDRNRLWYVpRHLCQLPSLNELSMAGNRL 192
Cdd:cd21340   83 V--EgLENLTNLEELHIENQRLppgekLTFDPRSLAALsnSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQI 154
LRR_8 pfam13855
Leucine rich repeat;
65-146 5.13e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 5.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767983273   65 PNLVELYLHSNNIVVV-PEAIGSLVKLQCLDLSdnaleivcpeigrlralrhlrlaNNQLQFLPPEV-GDLKELQTLDIS 142
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLS-----------------------NNLLTTLSPGAfSGLPSLRYLDLS 57


                  ....
gi 767983273  143 TNRL 146
Cdd:pfam13855  58 GNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
25-98 5.25e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.44  E-value: 5.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767983273   25 RNLHHFPLellkdegLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNI--VVVPEAIGSLVKLQCLDLSDN 98
Cdd:pfam14580  55 RKLDGFPL-------LRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLqeLGDLDPLASLKKLTFLSLLRN 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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