NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767959595|ref|XP_011517591|]
View 

abl interactor 1 isoform X6 [Homo sapiens]

Protein Classification

abl interactor 1( domain architecture ID 10544819)

abl interactor 1 is involved in regulating actin cytoskeletal reorganization and plays important roles in membrane-ruffling, endocytosis, cell motility, and cell migration

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Abi_HHR pfam07815
Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a ...
 93-156 2.63e-39

Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganization, but their precise role remains unclear.


:

Pssm-ID: 462279  Cd Length: 64  Bit Score: 132.05  E-value: 2.63e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767959595   93 ISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWL 156
Cdd:pfam07815   1 ISQTVDIHKEKVARREIGVLTTNKRLPRQQKIIAPANPEPPIKYSRKPIDYSCLDDIGHGVKDS 64
 
Name Accession Description Interval E-value
Abi_HHR pfam07815
Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a ...
 93-156 2.63e-39

Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganization, but their precise role remains unclear.


Pssm-ID: 462279  Cd Length: 64  Bit Score: 132.05  E-value: 2.63e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767959595   93 ISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWL 156
Cdd:pfam07815   1 ISQTVDIHKEKVARREIGVLTTNKRLPRQQKIIAPANPEPPIKYSRKPIDYSCLDDIGHGVKDS 64
 
Name Accession Description Interval E-value
Abi_HHR pfam07815
Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a ...
 93-156 2.63e-39

Abl-interactor HHR; The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganization, but their precise role remains unclear.


Pssm-ID: 462279  Cd Length: 64  Bit Score: 132.05  E-value: 2.63e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767959595   93 ISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWL 156
Cdd:pfam07815   1 ISQTVDIHKEKVARREIGVLTTNKRLPRQQKIIAPANPEPPIKYSRKPIDYSCLDDIGHGVKDS 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH