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Conserved domains on  [gi|755519478|ref|XP_011248834|]
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zinc finger protein 790 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-61 8.14e-25

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 97.66  E-value: 8.14e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 755519478     5 MTFRDVAVDFSPEEWECLSLDQKSLYRDVMLENYSHLVSVGLCIYQPHgfPVPEKEQ 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPD--LISQLEQ 55
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-686 4.98e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 4.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 224 FQCDECGKAFSFRSSLTGHKRIHTGEKPFTC--KECGKAFRFHSLLSVHVRTHTGEKSYECKACG---KFFNYSSDLTRH 298
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 299 HriHTGEKPYQCRECGKAFSCGSDLTRHERIHT---GEKPYECNECGKAFIQQSHLikhqrIHTGEKPYVCKEcgkAFTC 375
Cdd:COG5048  114 S--SNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSL-----HPPLPANSLSKD---PSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 376 GSQLSQHRKIHTGDKLHKCKECK--NSFSFALDHTQRQLIYIGEKFfedkeNGETFFPGAEFPQCETVHTGKKLY--ECK 451
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSssYSIPSSSSDQNLENSSSSLPL-----TTNSQLSPKSLLSQSPSSLSSSDSssSAS 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 452 ECGKAFSLRSIVSSLKKIH-------NREKLFKCKDCEKAFRCPSDLSRHQ--KIHTGE--KPYKCKE--CGKGFICRSD 518
Cdd:COG5048  259 ESPRSSLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDA 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 519 LGRHQRVHTGVKPYVCKecgkaftrgahLTQHQKIHSKKSHEFNEGEKAFSSGLENTPHSliptgeklwerkeygEAVLH 598
Cdd:COG5048  339 LKRHILLHTSISPAKEK-----------LLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKS---------------ETLSN 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 599 DPERTQLQAAKTTYdckekgkdfswHSHDTDLKavhiREKRFQCKECPKAFRYSSELTRHQRLHTgEKPYKCQECWKAFA 678
Cdd:COG5048  393 SCIRNFKRDSNLSL-----------HIITHLSF----RPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFR 456


                 ....*...
gi 755519478 679 SASDLARH 686
Cdd:COG5048  457 RDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
682-707 1.19e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 755519478  682 DLARHQRIHTGERPYECNECGKAFIQ 707
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-61 8.14e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 97.66  E-value: 8.14e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 755519478     5 MTFRDVAVDFSPEEWECLSLDQKSLYRDVMLENYSHLVSVGLCIYQPHgfPVPEKEQ 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPD--LISQLEQ 55
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-45 4.45e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.15  E-value: 4.45e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755519478    4 VMTFRDVAVDFSPEEWECLSLDQKSLYRDVMLENYSHLVSVG 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-43 1.16e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 1.16e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 755519478   5 MTFRDVAVDFSPEEWECLSLDQKSLYRDVMLENYSHLVS 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-686 4.98e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 4.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 224 FQCDECGKAFSFRSSLTGHKRIHTGEKPFTC--KECGKAFRFHSLLSVHVRTHTGEKSYECKACG---KFFNYSSDLTRH 298
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 299 HriHTGEKPYQCRECGKAFSCGSDLTRHERIHT---GEKPYECNECGKAFIQQSHLikhqrIHTGEKPYVCKEcgkAFTC 375
Cdd:COG5048  114 S--SNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSL-----HPPLPANSLSKD---PSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 376 GSQLSQHRKIHTGDKLHKCKECK--NSFSFALDHTQRQLIYIGEKFfedkeNGETFFPGAEFPQCETVHTGKKLY--ECK 451
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSssYSIPSSSSDQNLENSSSSLPL-----TTNSQLSPKSLLSQSPSSLSSSDSssSAS 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 452 ECGKAFSLRSIVSSLKKIH-------NREKLFKCKDCEKAFRCPSDLSRHQ--KIHTGE--KPYKCKE--CGKGFICRSD 518
Cdd:COG5048  259 ESPRSSLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDA 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 519 LGRHQRVHTGVKPYVCKecgkaftrgahLTQHQKIHSKKSHEFNEGEKAFSSGLENTPHSliptgeklwerkeygEAVLH 598
Cdd:COG5048  339 LKRHILLHTSISPAKEK-----------LLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKS---------------ETLSN 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 599 DPERTQLQAAKTTYdckekgkdfswHSHDTDLKavhiREKRFQCKECPKAFRYSSELTRHQRLHTgEKPYKCQECWKAFA 678
Cdd:COG5048  393 SCIRNFKRDSNLSL-----------HIITHLSF----RPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFR 456


                 ....*...
gi 755519478 679 SASDLARH 686
Cdd:COG5048  457 RDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-347 7.50e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.50e-05
                          10        20
                  ....*....|....*....|....*.
gi 755519478  322 DLTRHERIHTGEKPYECNECGKAFIQ 347
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
682-707 1.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 755519478  682 DLARHQRIHTGERPYECNECGKAFIQ 707
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-61 8.14e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 97.66  E-value: 8.14e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 755519478     5 MTFRDVAVDFSPEEWECLSLDQKSLYRDVMLENYSHLVSVGLCIYQPHgfPVPEKEQ 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPD--LISQLEQ 55
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-45 4.45e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.15  E-value: 4.45e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755519478    4 VMTFRDVAVDFSPEEWECLSLDQKSLYRDVMLENYSHLVSVG 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-43 1.16e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 1.16e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 755519478   5 MTFRDVAVDFSPEEWECLSLDQKSLYRDVMLENYSHLVS 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-686 4.98e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 4.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 224 FQCDECGKAFSFRSSLTGHKRIHTGEKPFTC--KECGKAFRFHSLLSVHVRTHTGEKSYECKACG---KFFNYSSDLTRH 298
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 299 HriHTGEKPYQCRECGKAFSCGSDLTRHERIHT---GEKPYECNECGKAFIQQSHLikhqrIHTGEKPYVCKEcgkAFTC 375
Cdd:COG5048  114 S--SNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSL-----HPPLPANSLSKD---PSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 376 GSQLSQHRKIHTGDKLHKCKECK--NSFSFALDHTQRQLIYIGEKFfedkeNGETFFPGAEFPQCETVHTGKKLY--ECK 451
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSssYSIPSSSSDQNLENSSSSLPL-----TTNSQLSPKSLLSQSPSSLSSSDSssSAS 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 452 ECGKAFSLRSIVSSLKKIH-------NREKLFKCKDCEKAFRCPSDLSRHQ--KIHTGE--KPYKCKE--CGKGFICRSD 518
Cdd:COG5048  259 ESPRSSLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDA 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 519 LGRHQRVHTGVKPYVCKecgkaftrgahLTQHQKIHSKKSHEFNEGEKAFSSGLENTPHSliptgeklwerkeygEAVLH 598
Cdd:COG5048  339 LKRHILLHTSISPAKEK-----------LLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKS---------------ETLSN 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 599 DPERTQLQAAKTTYdckekgkdfswHSHDTDLKavhiREKRFQCKECPKAFRYSSELTRHQRLHTgEKPYKCQECWKAFA 678
Cdd:COG5048  393 SCIRNFKRDSNLSL-----------HIITHLSF----RPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFR 456


                 ....*...
gi 755519478 679 SASDLARH 686
Cdd:COG5048  457 RDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
306-495 1.46e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 306 KPYQCRECGKAFSCGSDLTRHER--IHTGE--KPYECNE--CGKAFIQQSHLIKHQRIHTGEKPYVCKEC-------GKA 372
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519478 373 FTCGSQLSQHRKIHTGDK-----LHKCKECKNSFSFALDHTQRQLIYIGEKFfedkengetffpgaefpqcetvhtgkkl 447
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKksetlSNSCIRNFKRDSNLSLHIITHLSFRPYNC---------------------------- 419

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 755519478 448 yECKECGKAFSLRSIVSSLKKIHNREKLFKCKDCEKAFRCPSDLSRHQ 495
Cdd:COG5048  420 -KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-347 7.50e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.50e-05
                          10        20
                  ....*....|....*....|....*.
gi 755519478  322 DLTRHERIHTGEKPYECNECGKAFIQ 347
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
682-707 1.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 755519478  682 DLARHQRIHTGERPYECNECGKAFIQ 707
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-515 1.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.32e-04
                          10        20
                  ....*....|....*....|....*.
gi 755519478  490 DLSRHQKIHTGEKPYKCKECGKGFIC 515
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-319 1.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 755519478  294 DLTRHHRIHTGEKPYQCRECGKAFSC 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-375 1.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.55e-04
                          10        20
                  ....*....|....*....|....*.
gi 755519478  350 HLIKHQRIHTGEKPYVCKECGKAFTC 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 336-358 8.03e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 8.03e-04
                          10        20
                  ....*....|....*....|...
gi 755519478  336 YECNECGKAFIQQSHLIKHQRIH 358
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 696-718 8.18e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 8.18e-04
                          10        20
                  ....*....|....*....|...
gi 755519478  696 YECNECGKAFIQQSHLIKHQRVH 718
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
521-543 1.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|...
gi 755519478  521 RHQRVHTGVKPYVCKECGKAFTR 543
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-261 1.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.73e-03
                          10        20
                  ....*....|....*....|
gi 755519478  242 HKRIHTGEKPFTCKECGKAF 261
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
654-679 3.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 755519478  654 ELTRHQRLHTGEKPYKCQECWKAFAS 679
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-291 3.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.41e-03
                          10        20
                  ....*....|....*....|....*
gi 755519478  267 LSVHVRTHTGEKSYECKACGKFFNY 291
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 640-662 3.64e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.64e-03
                          10        20
                  ....*....|....*....|...
gi 755519478  640 FQCKECPKAFRYSSELTRHQRLH 662
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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