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Conserved domains on  [gi|755502807|ref|XP_011248014|]
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fibronectin type III domain-containing protein 3B isoform X1 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047016)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to fibronectin type-III domain-containing protein 3A/3B

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
540-799 4.33e-19

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 92.76  E-value: 4.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  540 NLKRSTQYKFRLTASNMEGKSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGGSEilkYLLEItdGTS 619
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  620 EAGQWEVAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKGVHLEW 695
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  696 DvPASESGceVSEYSVE-MTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGPPGQ 772
Cdd:COG3401   348 T-ASSDAD--VTGYNVYrSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424

                         250       260
                  ....*....|....*....|....*..
gi 755502807  773 cRAPRVSFTPDGCVLVGWESPASPGAD 799
Cdd:COG3401   425 -SLTASVDAVPLTDVAGATAAASAASN 450
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 481-570 1.21e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  481 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 556
Cdd:cd00063     1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 755502807  557 EGKSCPSEVLVCTT 570
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
832-1066 1.26e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  832 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 911
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  912 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 983
Cdd:COG3401   270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  984 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 1057
Cdd:COG3401   349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                  ....*....
gi 755502807 1058 PTLKAPRVT 1066
Cdd:COG3401   422 SGESLTASV 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-473 1.42e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  382 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEgKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 755502807  460 IGTSGYSQEVVCYT 473
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 7.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 755502807  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1017-1149 4.74e-08

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807 1017 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1093
Cdd:COG3401   193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755502807 1094 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1149
Cdd:COG3401   268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
540-799 4.33e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 92.76  E-value: 4.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  540 NLKRSTQYKFRLTASNMEGKSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGGSEilkYLLEItdGTS 619
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  620 EAGQWEVAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKGVHLEW 695
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  696 DvPASESGceVSEYSVE-MTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGPPGQ 772
Cdd:COG3401   348 T-ASSDAD--VTGYNVYrSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424

                         250       260
                  ....*....|....*....|....*..
gi 755502807  773 cRAPRVSFTPDGCVLVGWESPASPGAD 799
Cdd:COG3401   425 -SLTASVDAVPLTDVAGATAAASAASN 450
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 691-765 5.50e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 5.50e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755502807  691 VHLEWDVPASESGcEVSEYSVEMTEPENVASEVY---HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 765
Cdd:cd00063    17 VTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 481-570 1.21e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  481 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 556
Cdd:cd00063     1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 755502807  557 EGKSCPSEVLVCTT 570
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
832-1066 1.26e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  832 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 911
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  912 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 983
Cdd:COG3401   270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  984 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 1057
Cdd:COG3401   349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                  ....*....
gi 755502807 1058 PTLKAPRVT 1066
Cdd:COG3401   422 SGESLTASV 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-473 1.42e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  382 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEgKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 755502807  460 IGTSGYSQEVVCYT 473
Cdd:cd00063    80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
385-466 8.11e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 8.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807   385 PFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEGKRNSGFRQCF-FGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 463
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 755502807   464 GYS 466
Cdd:pfam00041   83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 575-659 1.47e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.47e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    575 PGPPTRPLIKgPVTSHGFSVKWDAPK-DNGGSEILKYllEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCI 653
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 755502807    654 STGGHS 659
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
878-950 3.72e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 3.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807   878 PSAHPDSPSVcLVLNWEEPCNNGSEILAYNIDLGD--------SCITVGNTTTHVMKNLLPETTYRIRIQAINEIGVGPF 949
Cdd:pfam00041    6 LTVTDVTSTS-LTVSWTPPPDGNGPITGYEVEYRPknsgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 755502807   950 S 950
Cdd:pfam00041   85 S 85
fn3 pfam00041
Fibronectin type III domain;
691-758 2.24e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.24e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755502807   691 VHLEWDVPASESGcEVSEYSVE---MTEPENVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 758
Cdd:pfam00041   16 LTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 889-957 6.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.37e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755502807  889 LVLNWEEPCNNGSEILAYNI----DLGDSCITV----GNTTTHVMKNLLPETTYRIRIQAINEIGVGPFSQFIKAKT 957
Cdd:cd00063    17 VTLSWTPPEDDGGPITGYVVeyreKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 7.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 755502807  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1017-1149 4.74e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807 1017 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1093
Cdd:COG3401   193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755502807 1094 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1149
Cdd:COG3401   268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 382-463 5.54e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 5.54e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    382 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITSYLLEWDEgKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 755502807    460 IGTS 463
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 283-363 8.43e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 8.43e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    283 EKPQVSNIQARAVVLSWAPPVglscgPHGGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    .
gi 755502807    363 N 363
Cdd:smart00060   79 G 79
fn3 pfam00041
Fibronectin type III domain;
285-367 4.83e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807   285 PQVSNIQARAVVLSWAPPVGLScGPhgglsfPYSYEVALS--DKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GP------ITGYEVEYRpkNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*
gi 755502807   363 NSVKG 367
Cdd:pfam00041   78 GGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 864-947 5.19e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 5.19e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    864 PDPVSTLCVLEEEPPSahpdspsvcLVLNWEEP--CNNGSEILAYNIDLGDS------CITVGNTTTHVMKNLLPETTYR 935
Cdd:smart00060    1 PSPPSNLRVTDVTSTS---------VTLSWEPPpdDGITGYIVGYRVEYREEgsewkeVNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 755502807    936 IRIQAINEIGVG 947
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1057-1130 8.78e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 8.78e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755502807 1057 PPTLKAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVYK--GEEATFQISGLQSNTDYRFRVCA 1130
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 478-560 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.04e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    478 PQMPLAPRLVRAGVTWITLQWSRPEGCSPEE-VITYTLDIQEDENDSHFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNM 556
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 755502807    557 EGKS 560
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1057-1130 1.27e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.27e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755502807   1057 PPTLKAPRVTQLEGNSCEIFWEtvPPMRGDPVSYVLQVLV---GRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVCA 1130
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWE--PPPDDGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
1057-1130 1.75e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.75e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755502807  1057 PPTlkAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVY--KGEEATFQISGLQSNTDYRFRVCA 1130
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
483-563 2.04e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807   483 APRLVRA---GVTWITLQWSRPEGCSpEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNMEG 558
Cdd:pfam00041    2 APSNLTVtdvTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 755502807   559 KSCPS 563
Cdd:pfam00041   81 EGPPS 85
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
540-799 4.33e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 92.76  E-value: 4.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  540 NLKRSTQYKFRLTASNMEGKSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGGSEilkYLLEItdGTS 619
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  620 EAGQWEVAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKGVHLEW 695
Cdd:COG3401   272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  696 DvPASESGceVSEYSVE-MTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGPPGQ 772
Cdd:COG3401   348 T-ASSDAD--VTGYNVYrSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424

                         250       260
                  ....*....|....*....|....*..
gi 755502807  773 cRAPRVSFTPDGCVLVGWESPASPGAD 799
Cdd:COG3401   425 -SLTASVDAVPLTDVAGATAAASAASN 450
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
569-945 2.86e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 86.98  E-value: 2.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  569 TTSPDRPGPPTRPLIKGPVTSHGFSVKWDAPKDNGGSEILKYLLEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKL 648
Cdd:COG3401   128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYY 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  649 RACCISTGGHSQCSESLPVRTLSLAPGQcrPPRVLGRPK-HKGVHLEWDvPASESGceVSEYSVEMTEPENVA-SEVYHG 726
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWD-PVTESD--ATGYRVYRSNSGDGPfTKVATV 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  727 PELECTVGNLLPGTVYRFRVRALN-DGGYGPYSDVSEITTAAGPPGQCRAPRVSFTPDGCVLVGWEspASPGADISEYRL 805
Cdd:COG3401   283 TTTSYTDTGLTNGTTYYYRVTAVDaAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWT--ASSDADVTGYNV 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  806 E-WGEDEQSLELVYHGPD-TCFEMRDLLPAAQYCCRLQAFNPAG-AGPYSELVHCQTPASAPDPVSTLCVLEEEPPSAHP 882
Cdd:COG3401   361 YrSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAG 440

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755502807  883 DSPSVclvlnWEEPCNNGSEILAYNIDLGDSCITVGNTTTHVMKNLLPETTYRIRIQAINEIG 945
Cdd:COG3401   441 ATAAA-----SAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVG 498
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
450-782 2.94e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.35  E-value: 2.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  450 YTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRPEGcspEEVITYTLDIQEDENDShFHPKY 529
Cdd:COG3401   205 YYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE---SDATGYRVYRSNSGDGP-FTKVA 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  530 TGEDLTCTVKNLKRSTQYKFRLTASNMEG-KSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGgseIL 608
Cdd:COG3401   281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS-GLTATAVGSSSITLSWTASSDAD---VT 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  609 KYLLEItdGTSEAGQWE-VAYSGSATEYVFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSLAPGQcRPPRVLGR 685
Cdd:COG3401   357 GYNVYR--STSGGGTYTkIAETVTTTSYTDTGLTPGTtyYYKVTA-VDAAGNESAPSEEVSATTASAASGE-SLTASVDA 432

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  686 PKHKGVHLEWDVPASESGCEVSEYSVEMTEPENVASEVYHGPELECTVGNLLPGTVYRFrVRALNDGGYGPYSDVSEITT 765
Cdd:COG3401   433 VPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSV-TTGSLVGGSGASSVTNSVSV 511

                         330
                  ....*....|....*..
gi 755502807  766 AAGPPGQCRAPRVSFTP 782
Cdd:COG3401   512 IGASAAAAVGGAPDGTP 528
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 691-765 5.50e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 5.50e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755502807  691 VHLEWDVPASESGcEVSEYSVEMTEPENVASEVY---HGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 765
Cdd:cd00063    17 VTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 575-669 1.44e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  575 PGPPTRPLIKgPVTSHGFSVKWDAPKDNGGsEILKYLLEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCIS 654
Cdd:cd00063     1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 755502807  655 TGGHSQCSESLPVRT 669
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 481-570 1.21e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  481 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 556
Cdd:cd00063     1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 755502807  557 EGKSCPSEVLVCTT 570
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
832-1066 1.26e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  832 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 911
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  912 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 983
Cdd:COG3401   270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  984 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 1057
Cdd:COG3401   349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                  ....*....
gi 755502807 1058 PTLKAPRVT 1066
Cdd:COG3401   422 SGESLTASV 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-473 1.42e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  382 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEgKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 755502807  460 IGTSGYSQEVVCYT 473
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
930-1150 1.47e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.49  E-value: 1.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  930 PETTYRIRIQAINEIGVGPFSQFIKAKTRPLPPSPPRL-ECAASGPQSLKLKWgDSNSKTHAAGDMVYtlQLEDRNKRFI 1008
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGlTATADTPGSVTLSW-DPVTESDATGYRVY--RSNSGDGPFT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807 1009 SIYRGPSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTKSVPPTLKAPRVTQLEGNSCEIFWETVPPmrGDP 1087
Cdd:COG3401   278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADV 355

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755502807 1088 VSYVLQVLVGRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVcacrRCVDTSQELSGAFSPSAA 1150
Cdd:COG3401   356 TGYNVYRSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKV----TAVDAAGNESAPSEEVSA 415
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 770-859 4.41e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 4.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  770 PGQCRAPRVSFTPDGCVLVGWESPASPGADISEYRLEW---GEDEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPA 846
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrekGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 755502807  847 GAGPYSELVHCQT 859
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
350-638 5.21e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.95  E-value: 5.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  350 PATDYHVRVYAVYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITSYLLEWDEGKrNSGFR 429
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  430 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRPegcSPEE 508
Cdd:COG3401   278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  509 VITYTLDiQEDENDSHFHP-KYTGEDLTCTVKNLKRSTQYKFRLTASNMEG-KSCPSEVLVCTTSPDRPGPPT---RPLI 583
Cdd:COG3401   355 VTGYNVY-RSTSGGGTYTKiAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAV 433

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755502807  584 KGPVTSHGFSVKWDAPKDNGGSEIL--------KYLLEITDGTSEAGQWEVAYSGSATEYVFT 638
Cdd:COG3401   434 PLTDVAGATAAASAASNPGVSAAVLadggdtgnAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
fn3 pfam00041
Fibronectin type III domain;
385-466 8.11e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 8.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807   385 PFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEGKRNSGFRQCF-FGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 463
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 755502807   464 GYS 466
Cdd:pfam00041   83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 575-659 1.47e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.47e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    575 PGPPTRPLIKgPVTSHGFSVKWDAPK-DNGGSEILKYllEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCI 653
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 755502807    654 STGGHS 659
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
878-950 3.72e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 3.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807   878 PSAHPDSPSVcLVLNWEEPCNNGSEILAYNIDLGD--------SCITVGNTTTHVMKNLLPETTYRIRIQAINEIGVGPF 949
Cdd:pfam00041    6 LTVTDVTSTS-LTVSWTPPPDGNGPITGYEVEYRPknsgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 755502807   950 S 950
Cdd:pfam00041   85 S 85
fn3 pfam00041
Fibronectin type III domain;
691-758 2.24e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.24e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755502807   691 VHLEWDVPASESGcEVSEYSVE---MTEPENVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 758
Cdd:pfam00041   16 LTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 674-755 4.28e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 4.28e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    674 PGQCRPPRVLGRPKHKgVHLEWDVPASE-SGCEVSEYSVEMTEPENVASEVYHGP-ELECTVGNLLPGTVYRFRVRALND 751
Cdd:smart00060    1 PSPPSNLRVTDVTSTS-VTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 755502807    752 GGYG 755
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 889-957 6.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.37e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755502807  889 LVLNWEEPCNNGSEILAYNI----DLGDSCITV----GNTTTHVMKNLLPETTYRIRIQAINEIGVGPFSQFIKAKT 957
Cdd:cd00063    17 VTLSWTPPEDDGGPITGYVVeyreKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 7.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 7.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 755502807  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
576-660 1.02e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 1.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807   576 GPPTRPLIKgPVTSHGFSVKWDAPKDnGGSEILKYLLEITDGTSEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCIST 655
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 755502807   656 GGHSQ 660
Cdd:pfam00041   79 GGEGP 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
593-795 2.28e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 58.80  E-value: 2.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  593 SVKWDAPKDNGGseilkYLLEITDGtseAGQWEVAYSGSATEYVFTHLKPGTlYKLRACCISTGGHSQCSESLPVRTLS- 671
Cdd:COG4733   555 TVSWDAPAGAVA-----YEVEWRRD---DGNWVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTg 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  672 -LAPgqcrPPRVLG---RPKHKGVHLEWDVPAsesGCEVSEYSVEM---TEPENVASEVYHGPELECTVGNLLPGTVYRF 744
Cdd:COG4733   626 kTAP----PPAPTGltaTGGLGGITLSWSFPV---DADTLRTEIRYsttGDWASATVAQALYPGNTYTLAGLKAGQTYYY 698

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 755502807  745 RVRALNDGG-YGPYSDVSEITTAAGPPGQCRAPRVSFTPDGCVLVGWESPAS 795
Cdd:COG4733   699 RARAVDRSGnVSAWWVSGQASADAAGILDAITGQILETELGQELDAIIQNAT 750
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1017-1149 4.74e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807 1017 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1093
Cdd:COG3401   193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755502807 1094 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1149
Cdd:COG3401   268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 382-463 5.54e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 5.54e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    382 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITSYLLEWDEgKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 755502807    460 IGTS 463
Cdd:smart00060   80 AGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
286-638 7.27e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.55  E-value: 7.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  286 QVSNIQARAVVLSWAPPvglscgPHGGLSfpySYEVALSDKGrDGKYKIIYSGEELECNLKDLRPATDYHVRVYAV-YNS 364
Cdd:COG3401   240 TATADTPGSVTLSWDPV------TESDAT---GYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAG 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  365 VKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITSYLLEWDEGKrNSGFRQ-CFFGSQKHCKLTK 443
Cdd:COG3401   310 NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSG-GGTYTKiAETVTTTSYTDTG 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  444 LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRP--EGCSPEEVITYTLDIQEDEN 521
Cdd:COG3401   387 LTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAasAASNPGVSAAVLADGGDTGN 466

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  522 DSHFHPkyTGEDLTCTVKNLKRSTQYKFRLTASNMEGKScpsevlVCTTSPDRPGPPTRPLIKGPVTSHGFSVKWDAPKD 601
Cdd:COG3401   467 AVPFTT--TSSTVTATTTDTTTANLSVTTGSLVGGSGAS------SVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTV 538

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 755502807  602 NGGSEILKYLLEITDGTSEAGQWEVAYSGSATEYVFT 638
Cdd:COG3401   539 GASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLIT 575
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 283-363 8.43e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 8.43e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    283 EKPQVSNIQARAVVLSWAPPVglscgPHGGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    .
gi 755502807    363 N 363
Cdd:smart00060   79 G 79
fn3 pfam00041
Fibronectin type III domain;
285-367 4.83e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807   285 PQVSNIQARAVVLSWAPPVGLScGPhgglsfPYSYEVALS--DKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GP------ITGYEVEYRpkNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*
gi 755502807   363 NSVKG 367
Cdd:pfam00041   78 GGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 864-947 5.19e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 5.19e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    864 PDPVSTLCVLEEEPPSahpdspsvcLVLNWEEP--CNNGSEILAYNIDLGDS------CITVGNTTTHVMKNLLPETTYR 935
Cdd:smart00060    1 PSPPSNLRVTDVTSTS---------VTLSWEPPpdDGITGYIVGYRVEYREEgsewkeVNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 755502807    936 IRIQAINEIGVG 947
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1057-1130 8.78e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 8.78e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755502807 1057 PPTLKAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVYK--GEEATFQISGLQSNTDYRFRVCA 1130
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 478-560 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.04e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    478 PQMPLAPRLVRAGVTWITLQWSRPEGCSPEE-VITYTLDIQEDENDSHFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNM 556
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 755502807    557 EGKS 560
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 770-849 1.96e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.96e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807    770 PGQCRAPRVSFTPDGCVLVGWESPASPGAD--ISEYRLEWGE-DEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPA 846
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 755502807    847 GAG 849
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 973-1052 7.82e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 7.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807  973 GPQSLKLKWgdSNSKTHAAGDMVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYT 1049
Cdd:cd00063    13 TSTSVTLSW--TPPEDDGGPITGYVVEYREKGSgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90


                  ...
gi 755502807 1050 FST 1052
Cdd:cd00063    91 VTT 93
fn3 pfam00041
Fibronectin type III domain;
786-852 1.14e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.14e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807   786 VLVGWESPASPGADISEYRLEW---GEDEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPAGAGPYS 852
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1057-1130 1.27e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.27e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755502807   1057 PPTLKAPRVTQLEGNSCEIFWEtvPPMRGDPVSYVLQVLV---GRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVCA 1130
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWE--PPPDDGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
1057-1130 1.75e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.75e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755502807  1057 PPTlkAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVY--KGEEATFQISGLQSNTDYRFRVCA 1130
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
483-563 2.04e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755502807   483 APRLVRA---GVTWITLQWSRPEGCSpEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNMEG 558
Cdd:pfam00041    2 APSNLTVtdvTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 755502807   559 KSCPS 563
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 971-1042 1.80e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.36  E-value: 1.80e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755502807    971 ASGPQSLKLKWGDSNSKTHAAGDMVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAMSEAGEG 1042
Cdd:smart00060   11 DVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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