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Conserved domains on  [gi|755544182|ref|XP_011242598|]
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ryanodine receptor 2 isoform X15 [Mus musculus]

Protein Classification

ryanodine receptor( domain architecture ID 11696383)

ryanodine receptor is a calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction; similar to human ryanodine receptor 2, also called cardiac muscle ryanodine receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_MIR_RyR2 cd23291
MIR domain, beta-trefoil fold, found in ryanodine receptor 2 (RyR2) and similar proteins; RyR2, ...
 223-406 5.42e-121

MIR domain, beta-trefoil fold, found in ryanodine receptor 2 (RyR2) and similar proteins; RyR2, also called RYR-2, or cardiac muscle ryanodine receptor-calcium release channel, or cardiac muscle ryanodine receptor, or type 2 ryanodine receptor, is a calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity of RYR-2 is modulated by formation of heterotetramers with RYR-3. RYR-2 is required for cellular calcium ion homeostasis. it plays an essential role in embryonic heart development. RYR-2 forms homotetramer and also forms heterotetramers with RYR-1 and RYR-3. RYR-2 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


:

Pssm-ID: 467762 [Multi-domain]  Cd Length: 184  Bit Score: 380.16  E-value: 5.42e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  223 GGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLM 302
Cdd:cd23291     1 GGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  303 EDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKSARMGSIQR 382
Cdd:cd23291    81 EDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQR 160

                         170       180
                  ....*....|....*....|....
gi 755544182  383 KAIMHHEGHMDDGLNLSRSQHEES 406
Cdd:cd23291   161 KAIMHHEGHMDDGLNLSRSQHEES 184
RR_TM4-6 pfam06459
Ryanodine Receptor TM 4-6; This region covers TM regions 4-6 of the ryanodine receptor 1 ...
 4313-4579 7.16e-110

Ryanodine Receptor TM 4-6; This region covers TM regions 4-6 of the ryanodine receptor 1 family.


:

Pssm-ID: 461918  Cd Length: 282  Bit Score: 352.85  E-value: 7.16e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4313 NMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPV-- 4390
Cdd:pfam06459    1 NMPDPTQDEVHGDVSEPEKDEEQEASGLPDLADAAGGEEEEDLLSDIFGLILKKEGGQYKVVPHDPEAGLGDLSETTAee 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4391 PVPEVQEKFQEQKAKEEKEEKE------------ETKSEPEKAEGEDGEKEEKAKDEKSKQKLRQLHTHRYGEPEVPESA 4458
Cdd:pfam06459   81 PPPLLKRKLQESEEAEDEEEEEeepkpepiekadGENGEKEEKPKEEETESEAPEEEEMKKKQRKRHSKKKEEPEAQGSA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4459 FWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSS-VVEGKELPTRTSSDTAKVTNSLDSSPHRIIAV 4537
Cdd:pfam06459  161 FWNELEVYQTKLLNYLARNFYNLRFLALFVAFAINFILLFYKVSTSPpDEEEEEGSGWGDSGSGSGGGSGEDEEEEEGPV 240

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 755544182  4538 HYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVI 4579
Cdd:pfam06459  241 YFVLEESTGYMEPTLRFLAILHTIISFLCIIGYYCLKVPLVI 282
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 448-641 1.26e-91

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


:

Pssm-ID: 460175  Cd Length: 199  Bit Score: 296.80  E-value: 1.26e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   448 SLQDLIGYFHPPDEHLEHEDKQNRL---RALKNRQNLFQEEGMINLVLECIDRLH-VYSSAAHFADVAGREAGESWKSIL 523
Cdd:pfam01365    1 LLRDLIFFFAGPEEEELHEEDLLKLmnnKPLRQRQNLMREQGVLETVMEVIDLLGaPFTGALLFAEDLGEEKNAPWKKIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   524 NSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPE-ALNIIKEGHIKSIISLLDKHGRNHK 602
Cdd:pfam01365   81 RLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQLGSPSLAEGTLDVLTALLMDNPElLLNYIKECHIKSFISLLRKHGRDPR 160

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 755544182   603 VLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRL 641
Cdd:pfam01365  161 YLDFLSDLCVCNGEAVRENQNLICRLLLPNPDLLLQTLL 199
SPRY2_RyR cd12878
SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of ...
 1079-1211 1.05e-87

SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1


:

Pssm-ID: 240458  Cd Length: 133  Bit Score: 282.65  E-value: 1.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1079 RIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDDRAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCM 1158
Cdd:cd12878     1 RTFRAEKTYAVTSGKWYFEFEVLTSGYMRVGWARPGFRPDLELGSDDLSYAFDGFLARKWHQGSESFGKQWQPGDVVGCM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755544182 1159 VDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFG 1211
Cdd:cd12878    81 LDLVDRTISFTLNGELLIDSSGSEVAFKDIEIGEGFVPACSLGVGQKGRLNLG 133
SPRY3_RyR cd12879
SPRY domain 3 (SPRY3) of ryanodine receptor (RyR); This SPRY domain (SPRY3) is the third of ...
 1405-1552 1.36e-80

SPRY domain 3 (SPRY3) of ryanodine receptor (RyR); This SPRY domain (SPRY3) is the third of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this third SPRY domain of the RyRs.


:

Pssm-ID: 293937  Cd Length: 151  Bit Score: 263.01  E-value: 1.36e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1405 DDRDDYEYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAG 1484
Cdd:cd12879     1 DDRDDPSALDLVDEYYYSVRIFPGQDPSNVWVGWVTSDFHLYDPSFDPDKVRNVTVTMGDEKGGVYESIKRQNCYMVCAG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755544182 1485 ESMSPGQGRNN---SNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELG 1552
Cdd:cd12879    81 ELLAEVGQDSSgraSQGLLIGCLIDTATGLLTFTANGKETSTRFQVEPGTKLFPAVFVRPTSKEVLQFELG 151
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 2117-2328 1.36e-80

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


:

Pssm-ID: 460175  Cd Length: 199  Bit Score: 265.22  E-value: 1.36e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2117 QIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMvNVLGG------------GESKEITFPKM 2184
Cdd:pfam01365    1 LLRDLIFFFAGPEEEELHEEDLLKLMNNKPLRQRQNLMREQGVLETVMEVI-DLLGApftgallfaedlGEEKNAPWKKI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2185 VANCCRFLCYFCRISRQNQKAMFDHLSYLLENssvgLASPAMRGSTpLDVAAASVMDNNELALalrepdlekvvRYLAGC 2264
Cdd:pfam01365   80 VRLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQ----LGSPSLAEGT-LDVLTALLMDNPELLL-----------NYIKEC 143

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755544182  2265 GLQSCQMLVSKGYPDigwnpvegERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALR 2328
Cdd:pfam01365  144 HIKSFISLLRKHGRD--------PRYLDFLSDLCVCNGEAVRENQNLICRLLLPNPDLLLQTLL 199
SPRY1_RyR cd12877
SPRY domain 1 (SPRY1) of ryanodine receptor (RyR); This SPRY domain is the first of three ...
 647-798 2.66e-80

SPRY domain 1 (SPRY1) of ryanodine receptor (RyR); This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this first SPRY domain of the RyRs.


:

Pssm-ID: 240457  Cd Length: 151  Bit Score: 262.25  E-value: 2.66e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  647 SMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTaEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLW 726
Cdd:cd12877     1 SIRPNIFVGVVEGSAQYKKWYFEVEVDHVEQFTH-QPAHLRVGWANTSGYVPYPGGGEGWGGNGVGDDLYSYGFDGLHLW 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755544182  727 SGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLG 798
Cdd:cd12877    80 TGGRSRRVTSGTQHLLKKGDVVGCCLDLSVPSISFRVNGRPVQGMFENFNLDGMFFPVMSFSAGVSCRFLLG 151
Ins145_P3_rec super family cl48031
Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding ...
 13-215 1.67e-72

Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.


The actual alignment was detected with superfamily member pfam08709:

Pssm-ID: 462572 [Multi-domain]  Cd Length: 212  Bit Score: 242.40  E-value: 1.67e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182    13 FLRTDDEVVLQCTATIhkeqqKLCLAAEGFGNRLCFLESTSNSKNVPP-DLSICTFVLEQSLSVRALQEMLANTVEKSEG 91
Cdd:pfam08709    4 FLHIGDIVSLSCEESV-----NGFISALGLGNDRCFVENKAGDLNDPPkKFRDCVFKICPANSYAAQKELWSAGNRSPNG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182    92 KFMMKT----AQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEK 167
Cdd:pfam08709   79 NSLTDAlkhaSNIEGHQNLQYGSAILLLHVKSNMYLAVLKSSPSLRDKNAMRVVLDEAGNGEGCWFIITPAYKQRSEGDN 158

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 755544182   168 VRVGDDLILVSVSSERYLHLS-----YGNSSWHVDAAFQQTLWSVAPISSGSE 215
Cdd:pfam08709  159 VCVGDEVILVPVSAPIFLHTTssselRDNPGKEVNASFGQTSWKMEPFMSGCE 211
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 2693-2782 2.54e-47

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


:

Pssm-ID: 460419  Cd Length: 90  Bit Score: 165.37  E-value: 2.54e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2693 FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYKLLSEKEKEIYRWPIKESLK 2772
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVRDDAAKTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182  2773 TMLAWGWRIE 2782
Cdd:pfam02026   81 TLLALGYTIE 90
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 855-944 1.23e-44

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


:

Pssm-ID: 460419  Cd Length: 90  Bit Score: 157.66  E-value: 1.23e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   855 FTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLK 934
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVRDDAAKTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182   935 TLLALGCHVG 944
Cdd:pfam02026   81 TLLALGYTIE 90
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 969-1058 5.18e-42

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


:

Pssm-ID: 460419  Cd Length: 90  Bit Score: 150.35  E-value: 5.18e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   969 YKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVR 1048
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVRDDAAKTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182  1049 TLLGYGYHLE 1058
Cdd:pfam02026   81 TLLALGYTIE 90
RIH_assoc pfam08454
RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) ...
 3811-3928 3.61e-40

RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels. There seems to be no known function for this domain. Also see the IP3-binding domain pfam01365 and pfam02815.


:

Pssm-ID: 462482  Cd Length: 98  Bit Score: 145.36  E-value: 3.61e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  3811 QDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISdfywyysgkdiideqgqrnfSKAI 3890
Cdd:pfam08454    1 QEVKIICRILRFLQLLCEGHNLDLQNYLRQQTNNKNSYNLVEETVDLLKAYCKSIN--------------------EKNI 60

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 755544182  3891 QVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFL 3928
Cdd:pfam08454   61 ELIIQCLDTLTEFIQGPCIENQIALCESKFLEIANDLL 98
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 2813-2896 2.74e-27

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


:

Pssm-ID: 460419  Cd Length: 90  Bit Score: 108.36  E-value: 2.74e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2813 YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGG------NHPLLVPYDTLTAKEKAKDREKAQDIFK 2886
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVrddaakTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182  2887 FLQISGYVVS 2896
Cdd:pfam02026   81 TLLALGYTIE 90
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 4698-4858 6.46e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 83.47  E-value: 6.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4698 SFLYLAWYMTMSVLG-HYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS 4776
Cdd:pfam00520   79 SLISLVLSSVGSLSGlRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4777 EDGDTPDMKCDDMLTCYMFHMYVgvRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQ 4856
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQT--MTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236


                   ..
gi 755544182  4857 QE 4858
Cdd:pfam00520  237 TE 238
EF-hand_7 pfam13499
EF-hand domain pair;
4012-4067 3.61e-06

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 47.25  E-value: 3.61e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 755544182  4012 FKEYDPDGKGVISKRDFHKAMESH---KHYTQSETEFLLSCAETDENETLDYEEFVKRF 4067
Cdd:pfam13499    8 FKLLDSDGDGYLDVEELKKLLRKLeegEPLSDEEVEELFKEFDLDKDGRISFEEFLELY 66
 
Name Accession Description Interval E-value
beta-trefoil_MIR_RyR2 cd23291
MIR domain, beta-trefoil fold, found in ryanodine receptor 2 (RyR2) and similar proteins; RyR2, ...
 223-406 5.42e-121

MIR domain, beta-trefoil fold, found in ryanodine receptor 2 (RyR2) and similar proteins; RyR2, also called RYR-2, or cardiac muscle ryanodine receptor-calcium release channel, or cardiac muscle ryanodine receptor, or type 2 ryanodine receptor, is a calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity of RYR-2 is modulated by formation of heterotetramers with RYR-3. RYR-2 is required for cellular calcium ion homeostasis. it plays an essential role in embryonic heart development. RYR-2 forms homotetramer and also forms heterotetramers with RYR-1 and RYR-3. RYR-2 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467762 [Multi-domain]  Cd Length: 184  Bit Score: 380.16  E-value: 5.42e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  223 GGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLM 302
Cdd:cd23291     1 GGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  303 EDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKSARMGSIQR 382
Cdd:cd23291    81 EDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQR 160

                         170       180
                  ....*....|....*....|....
gi 755544182  383 KAIMHHEGHMDDGLNLSRSQHEES 406
Cdd:cd23291   161 KAIMHHEGHMDDGLNLSRSQHEES 184
RR_TM4-6 pfam06459
Ryanodine Receptor TM 4-6; This region covers TM regions 4-6 of the ryanodine receptor 1 ...
 4313-4579 7.16e-110

Ryanodine Receptor TM 4-6; This region covers TM regions 4-6 of the ryanodine receptor 1 family.


Pssm-ID: 461918  Cd Length: 282  Bit Score: 352.85  E-value: 7.16e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4313 NMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPV-- 4390
Cdd:pfam06459    1 NMPDPTQDEVHGDVSEPEKDEEQEASGLPDLADAAGGEEEEDLLSDIFGLILKKEGGQYKVVPHDPEAGLGDLSETTAee 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4391 PVPEVQEKFQEQKAKEEKEEKE------------ETKSEPEKAEGEDGEKEEKAKDEKSKQKLRQLHTHRYGEPEVPESA 4458
Cdd:pfam06459   81 PPPLLKRKLQESEEAEDEEEEEeepkpepiekadGENGEKEEKPKEEETESEAPEEEEMKKKQRKRHSKKKEEPEAQGSA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4459 FWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSS-VVEGKELPTRTSSDTAKVTNSLDSSPHRIIAV 4537
Cdd:pfam06459  161 FWNELEVYQTKLLNYLARNFYNLRFLALFVAFAINFILLFYKVSTSPpDEEEEEGSGWGDSGSGSGGGSGEDEEEEEGPV 240

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 755544182  4538 HYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVI 4579
Cdd:pfam06459  241 YFVLEESTGYMEPTLRFLAILHTIISFLCIIGYYCLKVPLVI 282
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 448-641 1.26e-91

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


Pssm-ID: 460175  Cd Length: 199  Bit Score: 296.80  E-value: 1.26e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   448 SLQDLIGYFHPPDEHLEHEDKQNRL---RALKNRQNLFQEEGMINLVLECIDRLH-VYSSAAHFADVAGREAGESWKSIL 523
Cdd:pfam01365    1 LLRDLIFFFAGPEEEELHEEDLLKLmnnKPLRQRQNLMREQGVLETVMEVIDLLGaPFTGALLFAEDLGEEKNAPWKKIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   524 NSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPE-ALNIIKEGHIKSIISLLDKHGRNHK 602
Cdd:pfam01365   81 RLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQLGSPSLAEGTLDVLTALLMDNPElLLNYIKECHIKSFISLLRKHGRDPR 160

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 755544182   603 VLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRL 641
Cdd:pfam01365  161 YLDFLSDLCVCNGEAVRENQNLICRLLLPNPDLLLQTLL 199
SPRY2_RyR cd12878
SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of ...
 1079-1211 1.05e-87

SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1


Pssm-ID: 240458  Cd Length: 133  Bit Score: 282.65  E-value: 1.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1079 RIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDDRAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCM 1158
Cdd:cd12878     1 RTFRAEKTYAVTSGKWYFEFEVLTSGYMRVGWARPGFRPDLELGSDDLSYAFDGFLARKWHQGSESFGKQWQPGDVVGCM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755544182 1159 VDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFG 1211
Cdd:cd12878    81 LDLVDRTISFTLNGELLIDSSGSEVAFKDIEIGEGFVPACSLGVGQKGRLNLG 133
SPRY3_RyR cd12879
SPRY domain 3 (SPRY3) of ryanodine receptor (RyR); This SPRY domain (SPRY3) is the third of ...
 1405-1552 1.36e-80

SPRY domain 3 (SPRY3) of ryanodine receptor (RyR); This SPRY domain (SPRY3) is the third of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this third SPRY domain of the RyRs.


Pssm-ID: 293937  Cd Length: 151  Bit Score: 263.01  E-value: 1.36e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1405 DDRDDYEYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAG 1484
Cdd:cd12879     1 DDRDDPSALDLVDEYYYSVRIFPGQDPSNVWVGWVTSDFHLYDPSFDPDKVRNVTVTMGDEKGGVYESIKRQNCYMVCAG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755544182 1485 ESMSPGQGRNN---SNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELG 1552
Cdd:cd12879    81 ELLAEVGQDSSgraSQGLLIGCLIDTATGLLTFTANGKETSTRFQVEPGTKLFPAVFVRPTSKEVLQFELG 151
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 2117-2328 1.36e-80

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


Pssm-ID: 460175  Cd Length: 199  Bit Score: 265.22  E-value: 1.36e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2117 QIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMvNVLGG------------GESKEITFPKM 2184
Cdd:pfam01365    1 LLRDLIFFFAGPEEEELHEEDLLKLMNNKPLRQRQNLMREQGVLETVMEVI-DLLGApftgallfaedlGEEKNAPWKKI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2185 VANCCRFLCYFCRISRQNQKAMFDHLSYLLENssvgLASPAMRGSTpLDVAAASVMDNNELALalrepdlekvvRYLAGC 2264
Cdd:pfam01365   80 VRLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQ----LGSPSLAEGT-LDVLTALLMDNPELLL-----------NYIKEC 143

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755544182  2265 GLQSCQMLVSKGYPDigwnpvegERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALR 2328
Cdd:pfam01365  144 HIKSFISLLRKHGRD--------PRYLDFLSDLCVCNGEAVRENQNLICRLLLPNPDLLLQTLL 199
SPRY1_RyR cd12877
SPRY domain 1 (SPRY1) of ryanodine receptor (RyR); This SPRY domain is the first of three ...
 647-798 2.66e-80

SPRY domain 1 (SPRY1) of ryanodine receptor (RyR); This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this first SPRY domain of the RyRs.


Pssm-ID: 240457  Cd Length: 151  Bit Score: 262.25  E-value: 2.66e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  647 SMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTaEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLW 726
Cdd:cd12877     1 SIRPNIFVGVVEGSAQYKKWYFEVEVDHVEQFTH-QPAHLRVGWANTSGYVPYPGGGEGWGGNGVGDDLYSYGFDGLHLW 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755544182  727 SGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLG 798
Cdd:cd12877    80 TGGRSRRVTSGTQHLLKKGDVVGCCLDLSVPSISFRVNGRPVQGMFENFNLDGMFFPVMSFSAGVSCRFLLG 151
MIR pfam02815
MIR domain; The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may ...
 219-399 5.34e-75

MIR domain; The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function.


Pssm-ID: 397103 [Multi-domain]  Cd Length: 185  Bit Score: 248.43  E-value: 5.34e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   219 GYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRV-AWSGSHIRWGQPFRLRHVTTGK 297
Cdd:pfam02815    1 GYLKGGDVVRLFHSHQDEYLTGSEQQQKQPFLRITLYPHGDANNSARSLWRIEVVRHdAWRGGLIKWGSPFRLRHLTTGR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   298 YLSLMEDKNLLLMDKEKADVKSTAFAFRSS---KEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKS 374
Cdd:pfam02815   81 YLHSHEEQKPPLVEKEDWQKEVSAYGFRGFpgdNDIVEIFEKKSTTGMGSDRIKPGDSYFRLQHVCTGCWLFSHSVKLPK 160

                          170       180
                   ....*....|....*....|....*
gi 755544182   375 ARMGSIQRKAIMHHEGHMDDGLNLS 399
Cdd:pfam02815  161 WGFGPEQQKVTCAKEGHMDDALTLP 185
Ins145_P3_rec pfam08709
Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding ...
 13-215 1.67e-72

Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.


Pssm-ID: 462572 [Multi-domain]  Cd Length: 212  Bit Score: 242.40  E-value: 1.67e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182    13 FLRTDDEVVLQCTATIhkeqqKLCLAAEGFGNRLCFLESTSNSKNVPP-DLSICTFVLEQSLSVRALQEMLANTVEKSEG 91
Cdd:pfam08709    4 FLHIGDIVSLSCEESV-----NGFISALGLGNDRCFVENKAGDLNDPPkKFRDCVFKICPANSYAAQKELWSAGNRSPNG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182    92 KFMMKT----AQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEK 167
Cdd:pfam08709   79 NSLTDAlkhaSNIEGHQNLQYGSAILLLHVKSNMYLAVLKSSPSLRDKNAMRVVLDEAGNGEGCWFIITPAYKQRSEGDN 158

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 755544182   168 VRVGDDLILVSVSSERYLHLS-----YGNSSWHVDAAFQQTLWSVAPISSGSE 215
Cdd:pfam08709  159 VCVGDEVILVPVSAPIFLHTTssselRDNPGKEVNASFGQTSWKMEPFMSGCE 211
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 2693-2782 2.54e-47

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


Pssm-ID: 460419  Cd Length: 90  Bit Score: 165.37  E-value: 2.54e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2693 FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYKLLSEKEKEIYRWPIKESLK 2772
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVRDDAAKTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182  2773 TMLAWGWRIE 2782
Cdd:pfam02026   81 TLLALGYTIE 90
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 855-944 1.23e-44

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


Pssm-ID: 460419  Cd Length: 90  Bit Score: 157.66  E-value: 1.23e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   855 FTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLK 934
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVRDDAAKTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182   935 TLLALGCHVG 944
Cdd:pfam02026   81 TLLALGYTIE 90
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 969-1058 5.18e-42

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


Pssm-ID: 460419  Cd Length: 90  Bit Score: 150.35  E-value: 5.18e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   969 YKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVR 1048
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVRDDAAKTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182  1049 TLLGYGYHLE 1058
Cdd:pfam02026   81 TLLALGYTIE 90
RIH_assoc pfam08454
RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) ...
 3811-3928 3.61e-40

RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels. There seems to be no known function for this domain. Also see the IP3-binding domain pfam01365 and pfam02815.


Pssm-ID: 462482  Cd Length: 98  Bit Score: 145.36  E-value: 3.61e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  3811 QDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISdfywyysgkdiideqgqrnfSKAI 3890
Cdd:pfam08454    1 QEVKIICRILRFLQLLCEGHNLDLQNYLRQQTNNKNSYNLVEETVDLLKAYCKSIN--------------------EKNI 60

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 755544182  3891 QVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFL 3928
Cdd:pfam08454   61 ELIIQCLDTLTEFIQGPCIENQIALCESKFLEIANDLL 98
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 1092-1213 1.07e-33

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 127.80  E-value: 1.07e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   1092 GRWYFEFEAVTAGDMRVGWSRPGCQPDLE--LGSDDRAFAFDGFKAQRWHQGN-EHYGRSWQ-AGDVVGCMVDMNEHTMM 1167
Cdd:smart00449    2 GRHYFEVEIGDGGHWRVGVATKSVPRGYFalLGEDKGSWGYDGDGGKKYHNSTgPEYGLPLQePGDVIGCFLDLEAGTIS 81

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 755544182   1168 FTLNGEILlddsgSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKD 1213
Cdd:smart00449   82 FYKNGKYL-----HGLAFFDVKFSGPLYPAFSLGSGNSVRLNFGPL 122
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 1093-1213 2.01e-27

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 109.74  E-value: 2.01e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  1093 RWYFEFE--AVTAGDMRVGWSRPGCQ--PDLELGSDDRAFAFDGFKAQR-WHQGNEHYGR-SWQAGDVVGCMVDMNEHTM 1166
Cdd:pfam00622    1 RHYFEVEifGQDGGGWRVGWATKSVPrkGERFLGDESGSWGYDGWTGKKyWASTSPLTGLpLFEPGDVIGCFLDYEAGTI 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 755544182  1167 MFTLNGEILlddsgsELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKD 1213
Cdd:pfam00622   81 SFTKNGKSL------GYAFRDVPFAGPLFPAVSLGAGEGLKFNFGLR 121
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 2813-2896 2.74e-27

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


Pssm-ID: 460419  Cd Length: 90  Bit Score: 108.36  E-value: 2.74e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2813 YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGG------NHPLLVPYDTLTAKEKAKDREKAQDIFK 2886
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVrddaakTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182  2887 FLQISGYVVS 2896
Cdd:pfam02026   81 TLLALGYTIE 90
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 665-800 3.55e-26

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 106.27  E-value: 3.55e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   665 KWYYELMVDHTEPfvtaeaTHLRVGWAsTEGYSPYPGGGEEwggngvgDDLFSYGFDGlhlWSG--CIARTVSSPNQHLL 742
Cdd:pfam00622    1 RHYFEVEIFGQDG------GGWRVGWA-TKSVPRKGERFLG-------DESGSWGYDG---WTGkkYWASTSPLTGLPLF 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 755544182   743 RTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGR 800
Cdd:pfam00622   64 EPGDVIGCFLDYEAGTISFTKNGKSLGYAFRDVPFAGPLFPAVSLGAGEGLKFNFGLR 121
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 665-799 4.70e-23

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 97.37  E-value: 4.70e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182    665 KWYYELMVDHTepfvtaeaTHLRVGWASTEGYSPYpgggeewgGNGVGDDLFSYGFDGLHLwSGCIARTVSSPNQHLLRT 744
Cdd:smart00449    3 RHYFEVEIGDG--------GHWRVGVATKSVPRGY--------FALLGEDKGSWGYDGDGG-KKYHNSTGPEYGLPLQEP 65

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 755544182    745 DDVISCCLDLSAPSISFRINGQPVQGM-FENFNIDGLFFPVVSFSAGIKVRFLLGG 799
Cdd:smart00449   66 GDVIGCFLDLEAGTISFYKNGKYLHGLaFFDVKFSGPLYPAFSLGSGNSVRLNFGP 121
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 1418-1554 2.16e-22

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 95.49  E-value: 2.16e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  1418 TYYYSVRIFpGQEPANVWVGWITSDFHQYDTGFdldrvrtvtvtLGDEKGkvheSIKRSNCYMVCAGESMSPGQGRNNSN 1497
Cdd:pfam00622    1 RHYFEVEIF-GQDGGGWRVGWATKSVPRKGERF-----------LGDESG----SWGYDGWTGKKYWASTSPLTGLPLFE 64

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 755544182  1498 -GLEIGCVVDAASGLLTFIANGKELSTYYQVEPST-KLFPAVFAQatSPNVFQFELGRI 1554
Cdd:pfam00622   65 pGDVIGCFLDYEAGTISFTKNGKSLGYAFRDVPFAgPLFPAVSLG--AGEGLKFNFGLR 121
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 1418-1554 7.39e-18

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 82.34  E-value: 7.39e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   1418 TYYYSVRIFpgqEPANVWVGWITSDFHqydtgfdldrvRTVTVTLGDEKGK-VHESIKRSNCYMVCAGESMSPGQGRnns 1496
Cdd:smart00449    3 RHYFEVEIG---DGGHWRVGVATKSVP-----------RGYFALLGEDKGSwGYDGDGGKKYHNSTGPEYGLPLQEP--- 65

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   1497 nGLEIGCVVDAASGLLTFIANGKELS--TYYQVEPSTKLFPAVFAQatSPNVFQFELGRI 1554
Cdd:smart00449   66 -GDVIGCFLDLEAGTISFYKNGKYLHglAFFDVKFSGPLYPAFSLG--SGNSVRLNFGPL 122
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 4698-4858 6.46e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 83.47  E-value: 6.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4698 SFLYLAWYMTMSVLG-HYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS 4776
Cdd:pfam00520   79 SLISLVLSSVGSLSGlRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4777 EDGDTPDMKCDDMLTCYMFHMYVgvRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQ 4856
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQT--MTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236


                   ..
gi 755544182  4857 QE 4858
Cdd:pfam00520  237 TE 238
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
279-369 8.16e-07

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 48.88  E-value: 8.16e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182    279 GSHIRWGQPFRLRHVTTGKYLSLMEDKNLllmdkekadvkstafafRSSKEKldvgvrKEVDGMGTSEIkygdsicyiqh 358
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHDEKLP-----------------PWGDGQ------QEVTGYGNPAI----------- 46

                            90
                    ....*....|.
gi 755544182    359 VDTGLWLTYQA 369
Cdd:smart00472   47 DANTLWLIEPV 57
EF-hand_7 pfam13499
EF-hand domain pair;
4012-4067 3.61e-06

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 47.25  E-value: 3.61e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 755544182  4012 FKEYDPDGKGVISKRDFHKAMESH---KHYTQSETEFLLSCAETDENETLDYEEFVKRF 4067
Cdd:pfam13499    8 FKLLDSDGDGYLDVEELKKLLRKLeegEPLSDEEVEELFKEFDLDKDGRISFEEFLELY 66
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
4012-4072 1.02e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 48.25  E-value: 1.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755544182 4012 FKEYDPDGKGVISKRDFHKAMESHkHYTQSETEFLLSCAETDENETLDYEEFV---KRFHEPAK 4072
Cdd:COG5126    75 FDLLDTDGDGKISADEFRRLLTAL-GVSEEEADELFARLDTDGDGKISFEEFVaavRDYYTPDA 137
beta-trefoil_MIR_itr-1-like cd23280
MIR domain, beta-trefoil fold, found in Caenorhabditis elegans inositol 1,4,5-trisphosphate ...
 29-208 1.03e-04

MIR domain, beta-trefoil fold, found in Caenorhabditis elegans inositol 1,4,5-trisphosphate receptor Itr-1 and similar proteins; Itr-1, also called IP3 receptor, or IP3R, or InsP3R, or LET-23 fertility effector 1, is a receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. It binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity. It can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Itr-1 acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping. It affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior. It plays an important role in early embryonic development. It controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis. Itr-1 functions as a component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde, but no other ASH-mediated responses. Itr-1 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467751 [Multi-domain]  Cd Length: 199  Bit Score: 46.61  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   29 HKEQQ---------KLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSlsvralqemlantveksegkfmmKTAQ 99
Cdd:cd23280    17 HKELEaylsaegsfVDEVLTEDVHLRVRPVDDRKPRTLFPPTSGDTFWQIEKE-----------------------DTPL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  100 GGGhrTLLYGHAILLRHSYSGMYLCclstsrSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGekVRVGDDLILVSV 179
Cdd:cd23280    74 KGG--VIKWGDQCRLRHLPTGKYLA------VDDKTGNGKVVLTSDPSDPSTVFRLHPVTKETSEE--VKFGSYVRIEHV 143

                         170       180
                  ....*....|....*....|....*....
gi 755544182  180 SSERYLHLSYGNSSWHVDAAFQQTLWSVA 208
Cdd:cd23280   144 ATGTWLHAETDEELRRSKKSPAGLSWDGA 172
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 4010-4065 2.72e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 41.76  E-value: 2.72e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755544182 4010 DTFKEYDPDGKGVISKRDFHKAMESH-KHYTQSETEFLLSCAETDENETLDYEEFVK 4065
Cdd:cd00051     4 EAFRLFDKDGDGTISADELKAALKSLgEGLSEEEIDEMIREVDKDGDGKIDFEEFLE 60
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
103-158 7.65e-04

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 40.40  E-value: 7.65e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 755544182    103 HRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTG-EACWWTIHPA 158
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHDEKLPPWGDGQQEVTGYGNPAIdANTLWLIEPV 57
 
Name Accession Description Interval E-value
beta-trefoil_MIR_RyR2 cd23291
MIR domain, beta-trefoil fold, found in ryanodine receptor 2 (RyR2) and similar proteins; RyR2, ...
 223-406 5.42e-121

MIR domain, beta-trefoil fold, found in ryanodine receptor 2 (RyR2) and similar proteins; RyR2, also called RYR-2, or cardiac muscle ryanodine receptor-calcium release channel, or cardiac muscle ryanodine receptor, or type 2 ryanodine receptor, is a calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity of RYR-2 is modulated by formation of heterotetramers with RYR-3. RYR-2 is required for cellular calcium ion homeostasis. it plays an essential role in embryonic heart development. RYR-2 forms homotetramer and also forms heterotetramers with RYR-1 and RYR-3. RYR-2 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467762 [Multi-domain]  Cd Length: 184  Bit Score: 380.16  E-value: 5.42e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  223 GGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLM 302
Cdd:cd23291     1 GGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  303 EDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKSARMGSIQR 382
Cdd:cd23291    81 EDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQR 160

                         170       180
                  ....*....|....*....|....
gi 755544182  383 KAIMHHEGHMDDGLNLSRSQHEES 406
Cdd:cd23291   161 KAIMHHEGHMDDGLNLSRSQHEES 184
beta-trefoil_MIR_RyR cd23278
MIR domain, beta-trefoil fold, found in the family of ryanodine receptor (RyR); RyRs (also ...
 223-402 7.00e-112

MIR domain, beta-trefoil fold, found in the family of ryanodine receptor (RyR); RyRs (also called RYRs) are intracellular Ca(2+) release channels located on the sarco/endoplasmic reticulum (SR/ER). They release calcium Ca(2+) intracellular stores to activate critical functions including muscle contraction and neurotransmitter release. The family includes three closely homologous proteins, RyR1, RyR2 and RyR3. RyR1 is present in skeletal muscle; RyR2 is in heart muscle; and RyR3 is expressed at low levels in many tissues including brain, smooth muscle, and slow-twitch skeletal muscle. RYR2 is the major cellular mediator of calcium-induced calcium release (CICR) in animal cells. RyR1 and RyR2 release Ca2+ from the ER in response to excitation of muscle membranes to promote muscle contraction. RYR3 is involved in force production and calcium handling in extraocular muscle. RYRs contain an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467749 [Multi-domain]  Cd Length: 180  Bit Score: 353.92  E-value: 7.00e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  223 GGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLM 302
Cdd:cd23278     1 GGDVLRLFHGHMDECLTIPAAGSKEDQHRTVIYEGGAVSTHARSLWRLELLRIKWSGSHIGWGQPFRLRHVTTGRYLALT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  303 EDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKSARMGSIQR 382
Cdd:cd23278    81 EDRGLVLVPKEKADVKATAFCFRQSKDDKKVLDEKEDEGMGTPEIKYGDSLVFIQHVDTGLWLSYQAVETKKRVGGVEER 160

                         170       180
                  ....*....|....*....|
gi 755544182  383 KAIMHHEGHMDDGLNLSRSQ 402
Cdd:cd23278   161 KAILHAEGHMDDGLSLSRAQ 180
RR_TM4-6 pfam06459
Ryanodine Receptor TM 4-6; This region covers TM regions 4-6 of the ryanodine receptor 1 ...
 4313-4579 7.16e-110

Ryanodine Receptor TM 4-6; This region covers TM regions 4-6 of the ryanodine receptor 1 family.


Pssm-ID: 461918  Cd Length: 282  Bit Score: 352.85  E-value: 7.16e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4313 NMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPV-- 4390
Cdd:pfam06459    1 NMPDPTQDEVHGDVSEPEKDEEQEASGLPDLADAAGGEEEEDLLSDIFGLILKKEGGQYKVVPHDPEAGLGDLSETTAee 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4391 PVPEVQEKFQEQKAKEEKEEKE------------ETKSEPEKAEGEDGEKEEKAKDEKSKQKLRQLHTHRYGEPEVPESA 4458
Cdd:pfam06459   81 PPPLLKRKLQESEEAEDEEEEEeepkpepiekadGENGEKEEKPKEEETESEAPEEEEMKKKQRKRHSKKKEEPEAQGSA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4459 FWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSS-VVEGKELPTRTSSDTAKVTNSLDSSPHRIIAV 4537
Cdd:pfam06459  161 FWNELEVYQTKLLNYLARNFYNLRFLALFVAFAINFILLFYKVSTSPpDEEEEEGSGWGDSGSGSGGGSGEDEEEEEGPV 240

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 755544182  4538 HYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVI 4579
Cdd:pfam06459  241 YFVLEESTGYMEPTLRFLAILHTIISFLCIIGYYCLKVPLVI 282
beta-trefoil_MIR_RyR1 cd23290
MIR domain, beta-trefoil fold, found in ryanodine receptor 1 (RyR1) and similar proteins; RyR1, ...
 214-406 5.25e-103

MIR domain, beta-trefoil fold, found in ryanodine receptor 1 (RyR1) and similar proteins; RyR1, also called RYR-1, or skeletal muscle calcium release channel, or skeletal muscle ryanodine receptor, or skeletal muscle-type ryanodine receptor, or type 1 ryanodine receptor, is a calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. It can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. It is required for normal embryonic development of muscle fibers and skeletal muscle, as well as for normal heart morphogenesis, skin development and ossification during embryogenesis. RYR-1 forms homotetramer and can also form heterotetramers with RYR-2. RYR-1 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467761 [Multi-domain]  Cd Length: 192  Bit Score: 329.16  E-value: 5.25e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  214 SEAAQGYLIGGDVLRLLHGHMDECLTVPSGEhGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV 293
Cdd:cd23290     1 SCCEEGYVTGGHVLRLFHGHMDECLTISAAD-SDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  294 TTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVK 373
Cdd:cd23290    80 TTGRYLALTEDQGLVVVDACKAHTKATSFCFRVSKEKLDTAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPK 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 755544182  374 SARMGSIQRKAIMHHEGHMDDGLNLSRSQHEES 406
Cdd:cd23290   160 ALRLGVLKKKAILHQEGHMDDALFLTRCQQEES 192
beta-trefoil_MIR_RyR3 cd23292
MIR domain, beta-trefoil fold, found in ryanodine receptor 3 (RyR3) and similar proteins; RyR3, ...
 219-406 1.87e-98

MIR domain, beta-trefoil fold, found in ryanodine receptor 3 (RyR3) and similar proteins; RyR3, also called RYR-3, or brain ryanodine receptor-calcium release channel, or brain-type ryanodine receptor, or type 3 ryanodine receptor, is a calcium channel that plays a role in cellular calcium signaling. It mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. It also mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. RYR-3 forms homotetramer and also forms heterotetramer with RYR-2. RYR-3 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467763 [Multi-domain]  Cd Length: 187  Bit Score: 315.70  E-value: 1.87e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  219 GYLIGGDVLRLLHGHmDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKY 298
Cdd:cd23292     1 GYLLGGHVVRLFHGH-DECLTIPSTDQSDEQHRVVNYEAGGAGTRARSLWRLEPLRISWSGSHIRWGQTFRLRHLTTGHY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  299 LSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKSARMG 378
Cdd:cd23292    80 LALTEDQGLILQDRAKSDTKSTAFCFRASKEKLESGPKRDIDGMGIAEIKYGDSVCFVQHVASGLWLTYKAPDAKSSRLG 159

                         170       180
                  ....*....|....*....|....*...
gi 755544182  379 SIQRKAIMHHEGHMDDGLNLSRSQHEES 406
Cdd:cd23292   160 PLKRRAILHQEGHMDDGLTLQRCQHEES 187
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 448-641 1.26e-91

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


Pssm-ID: 460175  Cd Length: 199  Bit Score: 296.80  E-value: 1.26e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   448 SLQDLIGYFHPPDEHLEHEDKQNRL---RALKNRQNLFQEEGMINLVLECIDRLH-VYSSAAHFADVAGREAGESWKSIL 523
Cdd:pfam01365    1 LLRDLIFFFAGPEEEELHEEDLLKLmnnKPLRQRQNLMREQGVLETVMEVIDLLGaPFTGALLFAEDLGEEKNAPWKKIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   524 NSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPE-ALNIIKEGHIKSIISLLDKHGRNHK 602
Cdd:pfam01365   81 RLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQLGSPSLAEGTLDVLTALLMDNPElLLNYIKECHIKSFISLLRKHGRDPR 160

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 755544182   603 VLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRL 641
Cdd:pfam01365  161 YLDFLSDLCVCNGEAVRENQNLICRLLLPNPDLLLQTLL 199
SPRY2_RyR cd12878
SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of ...
 1079-1211 1.05e-87

SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1


Pssm-ID: 240458  Cd Length: 133  Bit Score: 282.65  E-value: 1.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1079 RIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDDRAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCM 1158
Cdd:cd12878     1 RTFRAEKTYAVTSGKWYFEFEVLTSGYMRVGWARPGFRPDLELGSDDLSYAFDGFLARKWHQGSESFGKQWQPGDVVGCM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755544182 1159 VDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFG 1211
Cdd:cd12878    81 LDLVDRTISFTLNGELLIDSSGSEVAFKDIEIGEGFVPACSLGVGQKGRLNLG 133
SPRY3_RyR cd12879
SPRY domain 3 (SPRY3) of ryanodine receptor (RyR); This SPRY domain (SPRY3) is the third of ...
 1405-1552 1.36e-80

SPRY domain 3 (SPRY3) of ryanodine receptor (RyR); This SPRY domain (SPRY3) is the third of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this third SPRY domain of the RyRs.


Pssm-ID: 293937  Cd Length: 151  Bit Score: 263.01  E-value: 1.36e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1405 DDRDDYEYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAG 1484
Cdd:cd12879     1 DDRDDPSALDLVDEYYYSVRIFPGQDPSNVWVGWVTSDFHLYDPSFDPDKVRNVTVTMGDEKGGVYESIKRQNCYMVCAG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755544182 1485 ESMSPGQGRNN---SNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELG 1552
Cdd:cd12879    81 ELLAEVGQDSSgraSQGLLIGCLIDTATGLLTFTANGKETSTRFQVEPGTKLFPAVFVRPTSKEVLQFELG 151
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 2117-2328 1.36e-80

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


Pssm-ID: 460175  Cd Length: 199  Bit Score: 265.22  E-value: 1.36e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2117 QIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMvNVLGG------------GESKEITFPKM 2184
Cdd:pfam01365    1 LLRDLIFFFAGPEEEELHEEDLLKLMNNKPLRQRQNLMREQGVLETVMEVI-DLLGApftgallfaedlGEEKNAPWKKI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2185 VANCCRFLCYFCRISRQNQKAMFDHLSYLLENssvgLASPAMRGSTpLDVAAASVMDNNELALalrepdlekvvRYLAGC 2264
Cdd:pfam01365   80 VRLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQ----LGSPSLAEGT-LDVLTALLMDNPELLL-----------NYIKEC 143

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755544182  2265 GLQSCQMLVSKGYPDigwnpvegERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALR 2328
Cdd:pfam01365  144 HIKSFISLLRKHGRD--------PRYLDFLSDLCVCNGEAVRENQNLICRLLLPNPDLLLQTLL 199
SPRY1_RyR cd12877
SPRY domain 1 (SPRY1) of ryanodine receptor (RyR); This SPRY domain is the first of three ...
 647-798 2.66e-80

SPRY domain 1 (SPRY1) of ryanodine receptor (RyR); This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this first SPRY domain of the RyRs.


Pssm-ID: 240457  Cd Length: 151  Bit Score: 262.25  E-value: 2.66e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  647 SMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTaEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLW 726
Cdd:cd12877     1 SIRPNIFVGVVEGSAQYKKWYFEVEVDHVEQFTH-QPAHLRVGWANTSGYVPYPGGGEGWGGNGVGDDLYSYGFDGLHLW 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755544182  727 SGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLG 798
Cdd:cd12877    80 TGGRSRRVTSGTQHLLKKGDVVGCCLDLSVPSISFRVNGRPVQGMFENFNLDGMFFPVMSFSAGVSCRFLLG 151
MIR pfam02815
MIR domain; The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may ...
 219-399 5.34e-75

MIR domain; The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function.


Pssm-ID: 397103 [Multi-domain]  Cd Length: 185  Bit Score: 248.43  E-value: 5.34e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   219 GYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRV-AWSGSHIRWGQPFRLRHVTTGK 297
Cdd:pfam02815    1 GYLKGGDVVRLFHSHQDEYLTGSEQQQKQPFLRITLYPHGDANNSARSLWRIEVVRHdAWRGGLIKWGSPFRLRHLTTGR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   298 YLSLMEDKNLLLMDKEKADVKSTAFAFRSS---KEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKS 374
Cdd:pfam02815   81 YLHSHEEQKPPLVEKEDWQKEVSAYGFRGFpgdNDIVEIFEKKSTTGMGSDRIKPGDSYFRLQHVCTGCWLFSHSVKLPK 160

                          170       180
                   ....*....|....*....|....*
gi 755544182   375 ARMGSIQRKAIMHHEGHMDDGLNLS 399
Cdd:pfam02815  161 WGFGPEQQKVTCAKEGHMDDALTLP 185
Ins145_P3_rec pfam08709
Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding ...
 13-215 1.67e-72

Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.


Pssm-ID: 462572 [Multi-domain]  Cd Length: 212  Bit Score: 242.40  E-value: 1.67e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182    13 FLRTDDEVVLQCTATIhkeqqKLCLAAEGFGNRLCFLESTSNSKNVPP-DLSICTFVLEQSLSVRALQEMLANTVEKSEG 91
Cdd:pfam08709    4 FLHIGDIVSLSCEESV-----NGFISALGLGNDRCFVENKAGDLNDPPkKFRDCVFKICPANSYAAQKELWSAGNRSPNG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182    92 KFMMKT----AQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEK 167
Cdd:pfam08709   79 NSLTDAlkhaSNIEGHQNLQYGSAILLLHVKSNMYLAVLKSSPSLRDKNAMRVVLDEAGNGEGCWFIITPAYKQRSEGDN 158

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 755544182   168 VRVGDDLILVSVSSERYLHLS-----YGNSSWHVDAAFQQTLWSVAPISSGSE 215
Cdd:pfam08709  159 VCVGDEVILVPVSAPIFLHTTssselRDNPGKEVNASFGQTSWKMEPFMSGCE 211
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 2693-2782 2.54e-47

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


Pssm-ID: 460419  Cd Length: 90  Bit Score: 165.37  E-value: 2.54e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2693 FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYKLLSEKEKEIYRWPIKESLK 2772
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVRDDAAKTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182  2773 TMLAWGWRIE 2782
Cdd:pfam02026   81 TLLALGYTIE 90
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 855-944 1.23e-44

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


Pssm-ID: 460419  Cd Length: 90  Bit Score: 157.66  E-value: 1.23e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   855 FTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLK 934
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVRDDAAKTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182   935 TLLALGCHVG 944
Cdd:pfam02026   81 TLLALGYTIE 90
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 969-1058 5.18e-42

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


Pssm-ID: 460419  Cd Length: 90  Bit Score: 150.35  E-value: 5.18e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   969 YKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVR 1048
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVRDDAAKTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182  1049 TLLGYGYHLE 1058
Cdd:pfam02026   81 TLLALGYTIE 90
RIH_assoc pfam08454
RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) ...
 3811-3928 3.61e-40

RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels. There seems to be no known function for this domain. Also see the IP3-binding domain pfam01365 and pfam02815.


Pssm-ID: 462482  Cd Length: 98  Bit Score: 145.36  E-value: 3.61e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  3811 QDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISdfywyysgkdiideqgqrnfSKAI 3890
Cdd:pfam08454    1 QEVKIICRILRFLQLLCEGHNLDLQNYLRQQTNNKNSYNLVEETVDLLKAYCKSIN--------------------EKNI 60

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 755544182  3891 QVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFL 3928
Cdd:pfam08454   61 ELIIQCLDTLTEFIQGPCIENQIALCESKFLEIANDLL 98
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 1092-1213 1.07e-33

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 127.80  E-value: 1.07e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   1092 GRWYFEFEAVTAGDMRVGWSRPGCQPDLE--LGSDDRAFAFDGFKAQRWHQGN-EHYGRSWQ-AGDVVGCMVDMNEHTMM 1167
Cdd:smart00449    2 GRHYFEVEIGDGGHWRVGVATKSVPRGYFalLGEDKGSWGYDGDGGKKYHNSTgPEYGLPLQePGDVIGCFLDLEAGTIS 81

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 755544182   1168 FTLNGEILlddsgSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKD 1213
Cdd:smart00449   82 FYKNGKYL-----HGLAFFDVKFSGPLYPAFSLGSGNSVRLNFGPL 122
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 1092-1209 7.93e-28

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 110.98  E-value: 7.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1092 GRWYFEFEAVTA--GDMRVGWSRPGCQPDLE--LGSDDRAFAFDGFKAQRWHQG-NEHYGRSWQAGDVVGCMVDMNEHTM 1166
Cdd:cd11709     1 GKWYWEVRVDSGngGLIQVGWATKSFSLDGEggVGDDEESWGYDGSRLRKGHGGsSGPGGRPWKSGDVVGCLLDLDEGTL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 755544182 1167 MFTLNGEILlddsGSelAFKDFDV-GDGFIPVCSLGVAQVGRMN 1209
Cdd:cd11709    81 SFSLNGKDL----GV--AFTNLFLkGGGLYPAVSLGSGQGVTIN 118
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 1093-1213 2.01e-27

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 109.74  E-value: 2.01e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  1093 RWYFEFE--AVTAGDMRVGWSRPGCQ--PDLELGSDDRAFAFDGFKAQR-WHQGNEHYGR-SWQAGDVVGCMVDMNEHTM 1166
Cdd:pfam00622    1 RHYFEVEifGQDGGGWRVGWATKSVPrkGERFLGDESGSWGYDGWTGKKyWASTSPLTGLpLFEPGDVIGCFLDYEAGTI 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 755544182  1167 MFTLNGEILlddsgsELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKD 1213
Cdd:pfam00622   81 SFTKNGKSL------GYAFRDVPFAGPLFPAVSLGAGEGLKFNFGLR 121
RyR pfam02026
RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four ...
 2813-2896 2.74e-27

RyR domain; This domain is called RyR for Ryanodine receptor. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.


Pssm-ID: 460419  Cd Length: 90  Bit Score: 108.36  E-value: 2.74e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  2813 YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGG------NHPLLVPYDTLTAKEKAKDREKAQDIFK 2886
Cdd:pfam02026    1 YKPKPVDTSNVTLPEDLEALVEKLAENTHEVWAKEKIEQGWTYGEVrddaakTHPCLVPYDLLTEKEKEYDREPARETLK 80

                           90
                   ....*....|
gi 755544182  2887 FLQISGYVVS 2896
Cdd:pfam02026   81 TLLALGYTIE 90
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 665-800 3.55e-26

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 106.27  E-value: 3.55e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   665 KWYYELMVDHTEPfvtaeaTHLRVGWAsTEGYSPYPGGGEEwggngvgDDLFSYGFDGlhlWSG--CIARTVSSPNQHLL 742
Cdd:pfam00622    1 RHYFEVEIFGQDG------GGWRVGWA-TKSVPRKGERFLG-------DESGSWGYDG---WTGkkYWASTSPLTGLPLF 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 755544182   743 RTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGR 800
Cdd:pfam00622   64 EPGDVIGCFLDYEAGTISFTKNGKSLGYAFRDVPFAGPLFPAVSLGAGEGLKFNFGLR 121
beta-trefoil_MIR cd23263
MIR domain, beta-trefoil fold, found in the MIR (protein mannosyltransferase, IP3R and RyR) ...
 224-391 7.23e-25

MIR domain, beta-trefoil fold, found in the MIR (protein mannosyltransferase, IP3R and RyR) superfamily; The MIR superfamily includes dolichyl-phosphate-mannose-protein mannosyltransferases (PMTs), inositol 1,4,5-trisphosphate receptors (ITPRs/IP3R), ryanodine receptors (RyRs), and stromal cell-derived factor 2 (SDF-2)-like proteins. They all contain a MIR domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The MIR domain may have a ligand transferase function.


Pssm-ID: 467746 [Multi-domain]  Cd Length: 172  Bit Score: 104.39  E-value: 7.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  224 GDVLRLLHGHMDECLTVPSGEHG-EEQRRTVHYEGGAVSVHARSLWRLETLRVAWsGSHIRWGQPFRLRHVTTGKYLSLM 302
Cdd:cd23263     1 GDVIWLKHSETGKYLHSHRKNYPtGSGQQEVTFESSSRKGDTNGLWIIESENGKQ-GGPVKWGDKIRLRHLSTGKYLSSE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  303 ED-KNLLLMDKE-----KADVKSTAFAFRSSKekldvgvrkevDGMGTSEIKYGDSICYIQHVDTGLWLTYQavDVKSAR 376
Cdd:cd23263    80 EGkKSPKSNHQEvlcltDNPDKSSLFKFEPIG-----------STKYKQKYVKKDSYFRLKHVNTNFWLHSH--EKKFNI 146

                         170
                  ....*....|....*
gi 755544182  377 MGSIQRKAIMHHEGH 391
Cdd:cd23263   147 NNKTQQEVICHGERE 161
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 665-799 4.70e-23

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 97.37  E-value: 4.70e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182    665 KWYYELMVDHTepfvtaeaTHLRVGWASTEGYSPYpgggeewgGNGVGDDLFSYGFDGLHLwSGCIARTVSSPNQHLLRT 744
Cdd:smart00449    3 RHYFEVEIGDG--------GHWRVGVATKSVPRGY--------FALLGEDKGSWGYDGDGG-KKYHNSTGPEYGLPLQEP 65

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 755544182    745 DDVISCCLDLSAPSISFRINGQPVQGM-FENFNIDGLFFPVVSFSAGIKVRFLLGG 799
Cdd:smart00449   66 GDVIGCFLDLEAGTISFYKNGKYLHGLaFFDVKFSGPLYPAFSLGSGNSVRLNFGP 121
SPRY_RNF123 cd12882
SPRY domain at N-terminus of ring finger protein 123; This SPRY domain is found at the ...
 1088-1211 7.21e-23

SPRY domain at N-terminus of ring finger protein 123; This SPRY domain is found at the N-terminus of RING finger protein 123 domain (also known as E3 ubiquitin-protein ligase RNF123). The ring finger domain motif is present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RNF123 displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor p27 (Kip1).


Pssm-ID: 293940  Cd Length: 128  Bit Score: 97.01  E-value: 7.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1088 AVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDDR--AFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHT 1165
Cdd:cd12882     7 CVYKGKWMYEVTLGTKGIMQIGWATISCRFTQEEGVGDTrdSYAYDGNRVRKWNVSTQKYGEPWVAGDVIGCCIDLDKGT 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 755544182 1166 MMFTLNGEILlddsgsELAFKDFDVGDG--FIPVCSLGVAQVGRMNFG 1211
Cdd:cd12882    87 ISFYRNGRSL------GVAFDNVRRGPGlaYFPAVSLSFGERLELNFG 128
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 1418-1554 2.16e-22

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 95.49  E-value: 2.16e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  1418 TYYYSVRIFpGQEPANVWVGWITSDFHQYDTGFdldrvrtvtvtLGDEKGkvheSIKRSNCYMVCAGESMSPGQGRNNSN 1497
Cdd:pfam00622    1 RHYFEVEIF-GQDGGGWRVGWATKSVPRKGERF-----------LGDESG----SWGYDGWTGKKYWASTSPLTGLPLFE 64

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 755544182  1498 -GLEIGCVVDAASGLLTFIANGKELSTYYQVEPST-KLFPAVFAQatSPNVFQFELGRI 1554
Cdd:pfam00622   65 pGDVIGCFLDYEAGTISFTKNGKSLGYAFRDVPFAgPLFPAVSLG--AGEGLKFNFGLR 121
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 665-796 3.01e-19

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 86.33  E-value: 3.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  665 KWYYELMVDHTEPfvtaeaTHLRVGWAsTEGYSPYPGGGEEwggngvgDDLFSYGFDG--LHLWSGCIartvSSPNQHLL 742
Cdd:cd11709     2 KWYWEVRVDSGNG------GLIQVGWA-TKSFSLDGEGGVG-------DDEESWGYDGsrLRKGHGGS----SGPGGRPW 63

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 755544182  743 RTDDVISCCLDLSAPSISFRINGQPVQGMFENFN-IDGLFFPVVSFSAGIKVRFL 796
Cdd:cd11709    64 KSGDVVGCLLDLDEGTLSFSLNGKDLGVAFTNLFlKGGGLYPAVSLGSGQGVTIN 118
SPRY_RING cd12883
SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain; This SPRY ...
 1092-1211 3.91e-19

SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain; This SPRY domain is found at the N-terminus of RING finger domains which are present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RING-finger domain is a type of Zn-finger that binds two Zn atoms and is identified in proteins with a wide range of functions such as viral replication, signal transduction, and development.


Pssm-ID: 293941  Cd Length: 121  Bit Score: 86.25  E-value: 3.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1092 GRWYFEFEAVTAGDMRVGWSRPGCQ----PDLELGSDDRAFAFDGFKAQRWH--QGNEHYGRSWQAGDVVGCMVDMNEHT 1165
Cdd:cd12883     1 GVWYYEVTVLTSGVMQIGWATKDSKflnhEGYGIGDDEYSCAYDGCRQLIWYnaKSKPHTHPRWKPGDVLGCLLDLNKKQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 755544182 1166 MMFTLNGEILLDDSGSELAFKdfdvgDGFIPVCSLGVAQVGRMNFG 1211
Cdd:cd12883    81 MIFSLNGNRLPPERQVFTSAK-----SGFFAAASFMSFQQCEFNFG 121
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 1418-1554 7.39e-18

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 82.34  E-value: 7.39e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   1418 TYYYSVRIFpgqEPANVWVGWITSDFHqydtgfdldrvRTVTVTLGDEKGK-VHESIKRSNCYMVCAGESMSPGQGRnns 1496
Cdd:smart00449    3 RHYFEVEIG---DGGHWRVGVATKSVP-----------RGYFALLGEDKGSwGYDGDGGKKYHNSTGPEYGLPLQEP--- 65

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   1497 nGLEIGCVVDAASGLLTFIANGKELS--TYYQVEPSTKLFPAVFAQatSPNVFQFELGRI 1554
Cdd:smart00449   66 -GDVIGCFLDLEAGTISFYKNGKYLHglAFFDVKFSGPLYPAFSLG--SGNSVRLNFGPL 122
beta-trefoil_MIR_itr-1-like cd23280
MIR domain, beta-trefoil fold, found in Caenorhabditis elegans inositol 1,4,5-trisphosphate ...
 215-365 1.00e-17

MIR domain, beta-trefoil fold, found in Caenorhabditis elegans inositol 1,4,5-trisphosphate receptor Itr-1 and similar proteins; Itr-1, also called IP3 receptor, or IP3R, or InsP3R, or LET-23 fertility effector 1, is a receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. It binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity. It can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Itr-1 acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping. It affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior. It plays an important role in early embryonic development. It controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis. Itr-1 functions as a component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde, but no other ASH-mediated responses. Itr-1 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467751 [Multi-domain]  Cd Length: 199  Bit Score: 84.74  E-value: 1.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  215 EAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHY----------EGGAVSVHARSLWRLETLRVAWSGSHIRW 284
Cdd:cd23280     1 KENENFLKGGDVVRLFHKELEAYLSAEGSFVDEVLTEDVHLrvrpvddrkpRTLFPPTSGDTFWQIEKEDTPLKGGVIKW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  285 GQPFRLRHVTTGKYLSLMEDKNLL-LMDKEKADVKSTAFAFRSskekldvgvrkeVDGMGTSEIKYGdSICYIQHVDTGL 363
Cdd:cd23280    81 GDQCRLRHLPTGKYLAVDDKTGNGkVVLTSDPSDPSTVFRLHP------------VTKETSEEVKFG-SYVRIEHVATGT 147


                  ..
gi 755544182  364 WL 365
Cdd:cd23280   148 WL 149
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 4698-4858 6.46e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 83.47  E-value: 6.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4698 SFLYLAWYMTMSVLG-HYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS 4776
Cdd:pfam00520   79 SLISLVLSSVGSLSGlRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  4777 EDGDTPDMKCDDMLTCYMFHMYVgvRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQ 4856
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQT--MTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236


                   ..
gi 755544182  4857 QE 4858
Cdd:pfam00520  237 TE 238
SPRY_DDX1 cd12873
SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD ...
 1086-1211 1.20e-14

SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD box gene, DDX1, an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication. It is suggested that DDX1 acts as a cellular cofactor by promoting oligomerization of Rev on the Rev response element (RRE). DDX1 RNA is overexpressed in breast cancer, data showing a strong and independent association between poor prognosis and deregulation of the DEAD box protein DDX1, thus potentially serving as an effective prognostic biomarker for early recurrence in primary breast cancer. DDX1 also interacts with RelA and enhances nuclear factor kappaB-mediated transcription. DEAD-box proteins are associated with all levels of RNA metabolism and function, and have been implicated in translation initiation, transcription, RNA splicing, ribosome assembly, RNA transport, and RNA decay.


Pssm-ID: 293933  Cd Length: 155  Bit Score: 74.53  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1086 TYAVKA-GRWYFEFEAVTAGDMRVGWSRPGCqpDLELGSDDRAFAFDGfKAQRWHQGN-EHYGRSWQAGDVVGCMVDMNE 1163
Cdd:cd12873    33 TKGVKGkGKYYYEVTVTDEGLCRVGWSTEDA--SLDLGTDKFGFGYGG-TGKKSHGRQfDDYGEPFGLGDVIGCYLDLDN 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 755544182 1164 HTMMFTLNGEILlddsGSELAFKDFDVGDGFIPVCSLGVAQVgRMNFG 1211
Cdd:cd12873   110 GTISFSKNGKDL----GKAFDIPPHLRNSALFPAVCLKNAEV-EFNFG 152
SPRY_Ash2 cd12872
SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or ...
 1074-1213 8.02e-14

SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or homeotic discs 2) -like proteins, core components of all mixed-lineage leukemia (MLL) family histone methyltransferases. Ash2 is a member of the trithorax group of transcriptional regulators of the Hox genes. Recent studies show that the SPRY domain of Ash2 mediates the interaction with RbBP5 and has an important role in regulating the methyltransferase activity of MLL complexes. In yeast, Ash2 is involved in histone methylation and is required for the earliest stages of embryogenesis.


Pssm-ID: 293932  Cd Length: 150  Bit Score: 71.78  E-value: 8.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1074 TGER-FRIFRAekTYAVKAGRWYFEFEAVTAGDM-----RVGWSRPGCqpDLE--LGSDDRAFAFDGFKAQRWHQGN-EH 1144
Cdd:cd12872    11 TGEKgYRMARA--NHGVREGKWYFEVKILEGGGTetghvRVGWSRREA--SLQapVGYDKYSYAIRDKDGSKFHQSRgKP 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755544182 1145 YGRSW-QAGDVVGCMVDMNEhtMMFTLNGEILlddsgsELAFKDFDVGDGFIPVCSL-GVAQVgRMNFGKD 1213
Cdd:cd12872    87 YGEPGfKEGDVIGFLITLPK--IEFFKNGKSQ------GVAFEDIYGTGGYYPAVSLyKGATV-TINFGPD 148
SPRY_RanBP_like cd12885
SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY ...
 1079-1211 1.06e-12

SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY domains found in Ran binding proteins (RBP or RanBPM) 9 and 10, SSH4 (suppressor of SHR3 null mutation protein 4), SPRY domain-containing protein 3 (SPRYD3) as well as HECT, a C-terminal catalytic domain of a subclass of ubiquitin-protein ligase (E3). RanBP9 and RanBP10 act as androgen receptor (AR) coactivators. Both consist of the N-terminal proline- and glutamine-rich regions, the SPRY domain, and LisH-CTLH and CRA motifs. The SPRY domain in SSH4 may be involved in cargo recognition, either directly or by combination with other adaptors, possibly leading to a higher selectivity. SPRYD3 is highly expressed in most tissues in humans, possibly involved in important cellular processes. HECT E3 mediates the direct transfer of ubiquitin from E2 to substrate.


Pssm-ID: 293943  Cd Length: 132  Bit Score: 68.07  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1079 RIFRAEKTYAVKAGRWYFE---FEAVTAGDMRVGWSRPGCQPDLELGSDDRAFAFDGFKAQRWHQG--NEHYGRSWQAGD 1153
Cdd:cd12885     1 GSVRADHPIPPKVPVFYFEvtiLDLGEKGIVSIGFCTSGFPLNRMPGWEDGSYGYHGDDGRVYLGGgeGENYGPPFGTGD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755544182 1154 VVGCMVDMNEHTMMFTLNGEILlddsGSelAFKDFDVGDgFIPVCSLGVAQVG-RMNFG 1211
Cdd:cd12885    81 VVGCGINFKTGEVFFTKNGELL----GT--AFENVVKGR-LYPTVGLGSPGVKvRVNFG 132
SPRY_hnRNP cd12884
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ...
 1074-1175 4.96e-10

SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation.


Pssm-ID: 293942  Cd Length: 177  Bit Score: 61.84  E-value: 4.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1074 TGERFRIF----RAekTYAVKAGRWYFE-------------FEAVTAGDMRVGWSRPGCQpdLELGSDDRAFAFDGfKAQ 1136
Cdd:cd12884    25 TDEGFAYLwagaRA--TYGVTKGKVCFEvkvtenlpvkhlpTEETDPHVVRVGWSVDSSS--LQLGEEEFSYGYGS-TGK 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 755544182 1137 RWHQGN-EHYGRSWQAGDVVGCMVDMNEH--TMMFTLNGEIL 1175
Cdd:cd12884   100 KSTNCKfEDYGEPFGENDVIGCYLDFESEpvEISFSKNGKDL 141
SPRY1_RyR cd12877
SPRY domain 1 (SPRY1) of ryanodine receptor (RyR); This SPRY domain is the first of three ...
 1067-1211 1.37e-09

SPRY domain 1 (SPRY1) of ryanodine receptor (RyR); This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this first SPRY domain of the RyRs.


Pssm-ID: 240457  Cd Length: 151  Bit Score: 59.63  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1067 RAEVCSGTGERFRIFRaektyavkagRWYFEF-----EAVT--AGDMRVGW-SRPGCQPDLE---------LGSDDRAFA 1129
Cdd:cd12877     3 RPNIFVGVVEGSAQYK----------KWYFEVevdhvEQFThqPAHLRVGWaNTSGYVPYPGggegwggngVGDDLYSYG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1130 FDGF------KAQRWHQGNEHYGRSwqaGDVVGCMVDMNEHTMMFTLNGEILlddSGSelaFKDFDVGDGFIPVCSLGVA 1203
Cdd:cd12877    73 FDGLhlwtggRSRRVTSGTQHLLKK---GDVVGCCLDLSVPSISFRVNGRPV---QGM---FENFNLDGMFFPVMSFSAG 143


                  ....*...
gi 755544182 1204 QVGRMNFG 1211
Cdd:cd12877   144 VSCRFLLG 151
SPRY2_RyR cd12878
SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of ...
 665-798 5.88e-09

SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1


Pssm-ID: 240458  Cd Length: 133  Bit Score: 57.31  E-value: 5.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  665 KWYYElmvdhtepFVTAEATHLRVGWASTEGYSPYPGGGeewggngvgDDLfSYGFDGL-----HLWSGCIARTvsspnq 739
Cdd:cd12878    15 KWYFE--------FEVLTSGYMRVGWARPGFRPDLELGS---------DDL-SYAFDGFlarkwHQGSESFGKQ------ 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755544182  740 hlLRTDDVISCCLDLSAPSISFRINGQPVQG------MFENFNIDGLFFPVVSFSAGIKVRFLLG 798
Cdd:cd12878    71 --WQPGDVVGCMLDLVDRTISFTLNGELLIDssgsevAFKDIEIGEGFVPACSLGVGQKGRLNLG 133
SPRY_Ash2 cd12872
SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or ...
 655-795 8.27e-09

SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or homeotic discs 2) -like proteins, core components of all mixed-lineage leukemia (MLL) family histone methyltransferases. Ash2 is a member of the trithorax group of transcriptional regulators of the Hox genes. Recent studies show that the SPRY domain of Ash2 mediates the interaction with RbBP5 and has an important role in regulating the methyltransferase activity of MLL complexes. In yeast, Ash2 is involved in histone methylation and is required for the earliest stages of embryogenesis.


Pssm-ID: 293932  Cd Length: 150  Bit Score: 57.53  E-value: 8.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  655 GVSEGsaqykKWYYELMVDHTEPFVTAeatHLRVGWASTE-------GYspypgggeewggngvgdDLFSYGF---DG-- 722
Cdd:cd12872    24 GVREG-----KWYFEVKILEGGGTETG---HVRVGWSRREaslqapvGY-----------------DKYSYAIrdkDGsk 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755544182  723 LHLWSGciaRTVSSPNqhlLRTDDVISCCLDLsaPSISFRINGQPvQG-MFENFNIDGLFFPVVSFSAGIKVRF 795
Cdd:cd12872    79 FHQSRG---KPYGEPG---FKEGDVIGFLITL--PKIEFFKNGKS-QGvAFEDIYGTGGYYPAVSLYKGATVTI 143
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
279-369 8.16e-07

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 48.88  E-value: 8.16e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182    279 GSHIRWGQPFRLRHVTTGKYLSLMEDKNLllmdkekadvkstafafRSSKEKldvgvrKEVDGMGTSEIkygdsicyiqh 358
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHDEKLP-----------------PWGDGQ------QEVTGYGNPAI----------- 46

                            90
                    ....*....|.
gi 755544182    359 VDTGLWLTYQA 369
Cdd:smart00472   47 DANTLWLIEPV 57
EF-hand_7 pfam13499
EF-hand domain pair;
4012-4067 3.61e-06

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 47.25  E-value: 3.61e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 755544182  4012 FKEYDPDGKGVISKRDFHKAMESH---KHYTQSETEFLLSCAETDENETLDYEEFVKRF 4067
Cdd:pfam13499    8 FKLLDSDGDGYLDVEELKKLLRKLeegEPLSDEEVEELFKEFDLDKDGRISFEEFLELY 66
beta-trefoil_MIR_ITPR1 cd23287
MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ...
 221-365 5.49e-06

MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) and similar proteins; ITPR1, also called IP3 receptor isoform 1 (IP3R 1), or InsP3R1, or type 1 inositol 1,4,5-trisphosphate receptor, or type 1 InsP3 receptor, is an intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. It is involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. It plays a role in endoplasmic reticulum (ER) stress-induced apoptosis. ITPR1 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467758 [Multi-domain]  Cd Length: 222  Bit Score: 50.84  E-value: 5.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  221 LIGGDVLRLLHGHMDECLTvpSGEHGEEQR---RTVHYEGGAVSVHARSLWRLETLRV-AWSGSHIRWGQPFRLRHVTTG 296
Cdd:cd23287    11 LKGGDVVRLFHAEQEKFLT--CDEHRKKQHvflRTTGRQSATSATSSKALWEVEVVQHdPCRGGAGYWNSLFRFKHLATG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  297 KYLSL-----MEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEI--------KYGDSIC----YI--Q 357
Cdd:cd23287    89 HYLAAevdpdFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIfeldpttlRGGDSLVprnsYVrlR 168


                  ....*...
gi 755544182  358 HVDTGLWL 365
Cdd:cd23287   169 HLCTNTWV 176
SPRY_RING cd12883
SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain; This SPRY ...
 666-798 6.28e-06

SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain; This SPRY domain is found at the N-terminus of RING finger domains which are present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RING-finger domain is a type of Zn-finger that binds two Zn atoms and is identified in proteins with a wide range of functions such as viral replication, signal transduction, and development.


Pssm-ID: 293941  Cd Length: 121  Bit Score: 48.50  E-value: 6.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  666 WYYELMVdhtepfVTAEAthLRVGWAST-------EGYSpypgggeewggngVGDDLFSYGFDGLH--LWSGciARtvSS 736
Cdd:cd12883     3 WYYEVTV------LTSGV--MQIGWATKdskflnhEGYG-------------IGDDEYSCAYDGCRqlIWYN--AK--SK 57

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755544182  737 PNQHL-LRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNI--DGlFFPVVSFSAGIKVRFLLG 798
Cdd:cd12883    58 PHTHPrWKPGDVLGCLLDLNKKQMIFSLNGNRLPPERQVFTSakSG-FFAAASFMSFQQCEFNFG 121
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 1419-1537 6.39e-06

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 48.20  E-value: 6.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1419 YYYSVRIFPGQEPaNVWVGWITSDFHQYDT----------GFDLDRVRTVTVtlgdekgkvhesikrsncymvcageSMS 1488
Cdd:cd11709     3 WYWEVRVDSGNGG-LIQVGWATKSFSLDGEggvgddeeswGYDGSRLRKGHG-------------------------GSS 56

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755544182 1489 PGQGRNNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTK--LFPAV 1537
Cdd:cd11709    57 GPGGRPWKSGDVVGCLLDLDEGTLSFSLNGKDLGVAFTNLFLKGggLYPAV 107
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
4012-4072 1.02e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 48.25  E-value: 1.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755544182 4012 FKEYDPDGKGVISKRDFHKAMESHkHYTQSETEFLLSCAETDENETLDYEEFV---KRFHEPAK 4072
Cdd:COG5126    75 FDLLDTDGDGKISADEFRRLLTAL-GVSEEEADELFARLDTDGDGKISFEEFVaavRDYYTPDA 137
SPRY_PRY_TRIM67_9 cd12889
PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67; This domain, ...
 1092-1187 2.13e-05

PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of TRIM9 proteins. TRIM9 protein is expressed mainly in the cerebral cortex, and functions as an E3 ubiquitin ligase. It has been shown that TRIM9 is localized to the neurons in the normal human brain and its immunoreactivity in affected brain areas in Parkinson's disease and dementia with Lewy bodies is severely decreased, possibly playing an important role in the regulation of neuronal function and participating in pathological process of Lewy body disease through its ligase. TRIM67 negatively regulates Ras activity via degradation of 80K-H, leading to neural differentiation, including neuritogenesis.


Pssm-ID: 293947  Cd Length: 172  Bit Score: 48.01  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182 1092 GRWYFEF---EAVTAGDMRVGWSRPGCQPDLELGSDDRAFA--FDGfkaQR-WHQ-GNEHYGRS---WQAGDVVGCMVDM 1161
Cdd:cd12889    49 GVHYWEVtidRYDGHPDPAFGVARIDVNKDKMLGKDDKGWSmyIDN---NRsWFLhNNEHSNRTeggITVGSVVGVLLDL 125

                          90       100
                  ....*....|....*....|....*.
gi 755544182 1162 NEHTMMFTLNGEillddSGSELAFKD 1187
Cdd:cd12889   126 DRHTLSFYVNDE-----PQGPIAFRN 146
beta-trefoil_MIR_ITPR2 cd23288
MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) ...
 205-300 2.23e-05

MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) and similar proteins; ITPR2, also called IP3 receptor isoform 2 (IP3R 2), or InsP3R2, or type 2 inositol 1,4,5-trisphosphate receptor, or type 2 InsP3 receptor, is a key regulator for the activity of calcium ion transmembrane transportation, which plays a critical role in cell cycle and proliferation. It is a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of cAMP-dependent protein kinase (PKA). ITPR2 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467759 [Multi-domain]  Cd Length: 222  Bit Score: 48.88  E-value: 2.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  205 WSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVpsGEHGEEQR---RTVHYEGGAVSVHARSLWRLETLRV-AWSGS 280
Cdd:cd23288     1 WKVTLFMKFSDYREDILKGGDVVRLFHAEQEKFLTC--DEYKKKQHiflRTTLRQSATSATSSKALWEIEVVHYdPCRGG 78

                          90       100
                  ....*....|....*....|
gi 755544182  281 HIRWGQPFRLRHVTTGKYLS 300
Cdd:cd23288    79 AGQWNSLFRFKHLATGNYLA 98
beta-trefoil_MIR_SDF2-like cd23279
MIR domain, beta-trefoil fold, found in family of stromal cell-derived factor 2 (SDF-2); The ...
 174-300 3.50e-05

MIR domain, beta-trefoil fold, found in family of stromal cell-derived factor 2 (SDF-2); The SDF-2 family includes mammalian SDF-2 and SDF2-like protein 1 (SDF2L1) as well as similar proteins from plant, such as Arabidopsis thaliana stromal cell-derived factor 2-like protein (AtSDF2). SDF-2 is a secretory protein involved in multiple endoplasmic reticulum (ER) functions, including the misfolded protein catabolic process, protein glycosylation, and ER protein quality control. SDF2L1, also called PWP1-interacting protein 8, is an endoplasmic reticulum (ER)-localized protein that plays a role in ER-associated degradation (ERAD) of misfolded proinsulin in pancreatic beta-cells. It is a component of the endoplasmic reticulum (ER) chaperone complex and interacts with alpha- and beta-defensins. SDF2L1 may also act as a tumor suppressor that play an important role in a variety of cancers, such as breast cancer and ovarian cancer. AtSDF2, also called SDF2-like protein, acts as crucial component of the unfolded protein response (UPR) in Arabidopsis thaliana. It is involved in the endoplasmic reticulum (ER) protein quality control and unfolded protein response. It may be involved in the quality control of glycoproteins. AtSDF2 forms a complex in the ER with ERDJ3B and MED37A/BIP1 which is required for the proper accumulation and function of the surface-exposed leucine-rich repeat receptor kinases EFR involved in pathogen-associated molecular pattern (PAMP) triggered immunity. Members in this family contain a MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467750 [Multi-domain]  Cd Length: 173  Bit Score: 47.68  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  174 LILVSVSSERYLH---LSYGNSS--------WHVDAAfqQTLWSVAPISSGSEAAQGYLIG-GDVLRL--------LHGH 233
Cdd:cd23279     5 IKLKHVNSGYRLHsheVSYGSGSgqqsvtavPSADDA--NSLWTVLPGLGEPCQEQGKPVKcGDIIRLqhvntrknLHSH 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755544182  234 MdecLTVPSGEHGEeqrrtvhyeggaVSVHARS------LWRLETLRVawSGSHIRWGQPFRLRHVTTGKYLS 300
Cdd:cd23279    83 N---HSSPLSGNQE------------VSAFGGGdedsgdNWIVECEGK--KAKFWKRGEPVRLKHVDTGKYLS 138
beta-trefoil_MIR_itr-1-like cd23280
MIR domain, beta-trefoil fold, found in Caenorhabditis elegans inositol 1,4,5-trisphosphate ...
 29-208 1.03e-04

MIR domain, beta-trefoil fold, found in Caenorhabditis elegans inositol 1,4,5-trisphosphate receptor Itr-1 and similar proteins; Itr-1, also called IP3 receptor, or IP3R, or InsP3R, or LET-23 fertility effector 1, is a receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. It binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity. It can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Itr-1 acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping. It affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior. It plays an important role in early embryonic development. It controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis. Itr-1 functions as a component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde, but no other ASH-mediated responses. Itr-1 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467751 [Multi-domain]  Cd Length: 199  Bit Score: 46.61  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182   29 HKEQQ---------KLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSlsvralqemlantveksegkfmmKTAQ 99
Cdd:cd23280    17 HKELEaylsaegsfVDEVLTEDVHLRVRPVDDRKPRTLFPPTSGDTFWQIEKE-----------------------DTPL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  100 GGGhrTLLYGHAILLRHSYSGMYLCclstsrSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGekVRVGDDLILVSV 179
Cdd:cd23280    74 KGG--VIKWGDQCRLRHLPTGKYLA------VDDKTGNGKVVLTSDPSDPSTVFRLHPVTKETSEE--VKFGSYVRIEHV 143

                         170       180
                  ....*....|....*....|....*....
gi 755544182  180 SSERYLHLSYGNSSWHVDAAFQQTLWSVA 208
Cdd:cd23280   144 ATGTWLHAETDEELRRSKKSPAGLSWDGA 172
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 4010-4065 2.72e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 41.76  E-value: 2.72e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755544182 4010 DTFKEYDPDGKGVISKRDFHKAMESH-KHYTQSETEFLLSCAETDENETLDYEEFVK 4065
Cdd:cd00051     4 EAFRLFDKDGDGTISADELKAALKSLgEGLSEEEIDEMIREVDKDGDGKIDFEEFLE 60
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
103-158 7.65e-04

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 40.40  E-value: 7.65e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 755544182    103 HRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTG-EACWWTIHPA 158
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHDEKLPPWGDGQQEVTGYGNPAIdANTLWLIEPV 57
SPRY_RNF123 cd12882
SPRY domain at N-terminus of ring finger protein 123; This SPRY domain is found at the ...
 665-790 2.00e-03

SPRY domain at N-terminus of ring finger protein 123; This SPRY domain is found at the N-terminus of RING finger protein 123 domain (also known as E3 ubiquitin-protein ligase RNF123). The ring finger domain motif is present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RNF123 displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor p27 (Kip1).


Pssm-ID: 293940  Cd Length: 128  Bit Score: 41.54  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  665 KWYYELMVdHTEPFvtaeathLRVGWAS-------TEGYSpypgggeewggngvgDDLFSYGFDG--LHLWSGCiartvS 735
Cdd:cd12882    12 KWMYEVTL-GTKGI-------MQIGWATiscrftqEEGVG---------------DTRDSYAYDGnrVRKWNVS-----T 63

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755544182  736 SPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNI-DGL-FFPVVSFSAG 790
Cdd:cd12882    64 QKYGEPWVAGDVIGCCIDLDKGTISFYRNGRSLGVAFDNVRRgPGLaYFPAVSLSFG 120
beta-trefoil_MIR_ITPR cd23277
MIR domain, beta-trefoil fold, found in the family of inositol 1,4,5-trisphosphate receptor ...
 214-304 3.36e-03

MIR domain, beta-trefoil fold, found in the family of inositol 1,4,5-trisphosphate receptor (ITPR); Inositol 1,4,5 trisphosphate receptors (ITPRs) are a family of endoplasmic reticulum Ca2+ channels essential for the control of intracellular Ca2+ levels in virtually every mammalian cell type. Calcium-mediated signaling through ITPRs is essential for the regulation of numerous physiological processes, including fertilization, muscle contraction, apoptosis, secretion, and synaptic plasticity. The ITPR family includes three isoforms (ITPR1, ITPR2 and ITPR3), which can control different cellular processes due to their unique biophysical properties, subcellular localization, and tissue distribution. ITPRs contain an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467748 [Multi-domain]  Cd Length: 204  Bit Score: 42.34  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755544182  214 SEAAQGYLIGGDVLRLLHGHMDECLTvpSGEHGEEQR---RTVHYEGGAVSVHARSLWRLETL-----RvawsGSHIRWG 285
Cdd:cd23277     4 KENLEDVLKGGDVVRLFHAEQEKFLT--CDEYKKKQYvflRTTGRTSATSATSSKALWEVEVVqhdpcR----GGAGHWN 77

                          90
                  ....*....|....*....
gi 755544182  286 QPFRLRHVTTGKYLSLMED 304
Cdd:cd23277    78 SLFRFKHLATGQYLAAEVD 96
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
165-210 3.70e-03

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 38.48  E-value: 3.70e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 755544182    165 GEKVRVGDDLILVSVSSERYLHLS----YGNSSWH-------VDAAFQQTLWSVAPI 210
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHdeklPPWGDGQqevtgygNPAIDANTLWLIEPV 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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