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Conserved domains on  [gi|755541407|ref|XP_011242185|]
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centromere protein O isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRWD-N_CENP-O cd23835
N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 102-182 3.80e-26

N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the N-terminal double-RWD domain (DRWD-N).


:

Pssm-ID: 467668  Cd Length: 86  Bit Score: 97.66  E-value: 3.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541407 102 ILEAYRFTGLSGKLT-SRGVCMCISTAFEGNLLDSYFVDLVIEKP--LRIHHHSVPVFIPLEKIAAAHLQTDVQRFLFRL 178
Cdd:cd23835    3 LLQAYRLTGRSVFEVdGNRLGVRFDTFYEGTYLESYYIDLEIKSPlsLKISRHTLPYFIPLEELEKKYLQTDLKKFLSVV 82


                 ....
gi 755541407 179 WEYL 182
Cdd:cd23835   83 SEYL 86
DRWD-C_CENP-O cd23836
C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 183-251 6.17e-16

C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the C-terminal double-RWD domain (DRWD-C).


:

Pssm-ID: 467669  Cd Length: 98  Bit Score: 71.18  E-value: 6.17e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755541407 183 NAYAGRKYQADQLESDFcDVLTGPLQRNALCNLLSFTYKVeqRCQTFSFSARLLYEDPTAALPTNVTVT 251
Cdd:cd23836    1 NAYVSRREQVDQLKELF-GEFVGEIEHSSAYDFISFSLKV--STGSGRFEVTLKYDDLTSELPTEVTVT 66
COG1340 super family cl34231
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
28-68 9.22e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


The actual alignment was detected with superfamily member COG1340:

Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 36.81  E-value: 9.22e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 755541407  28 TNISNRKSEEPAVRKKESSLRTKIRELRQQRDKLRAEVKQW 68
Cdd:COG1340    1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKEL 41
 
Name Accession Description Interval E-value
DRWD-N_CENP-O cd23835
N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 102-182 3.80e-26

N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the N-terminal double-RWD domain (DRWD-N).


Pssm-ID: 467668  Cd Length: 86  Bit Score: 97.66  E-value: 3.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541407 102 ILEAYRFTGLSGKLT-SRGVCMCISTAFEGNLLDSYFVDLVIEKP--LRIHHHSVPVFIPLEKIAAAHLQTDVQRFLFRL 178
Cdd:cd23835    3 LLQAYRLTGRSVFEVdGNRLGVRFDTFYEGTYLESYYIDLEIKSPlsLKISRHTLPYFIPLEELEKKYLQTDLKKFLSVV 82


                 ....
gi 755541407 179 WEYL 182
Cdd:cd23835   83 SEYL 86
DRWD-C_CENP-O cd23836
C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 183-251 6.17e-16

C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the C-terminal double-RWD domain (DRWD-C).


Pssm-ID: 467669  Cd Length: 98  Bit Score: 71.18  E-value: 6.17e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755541407 183 NAYAGRKYQADQLESDFcDVLTGPLQRNALCNLLSFTYKVeqRCQTFSFSARLLYEDPTAALPTNVTVT 251
Cdd:cd23836    1 NAYVSRREQVDQLKELF-GEFVGEIEHSSAYDFISFSLKV--STGSGRFEVTLKYDDLTSELPTEVTVT 66
CENP-O pfam09496
Cenp-O kinetochore centromere component; This eukaryotic protein is a component of the inner ...
 124-199 2.41e-04

Cenp-O kinetochore centromere component; This eukaryotic protein is a component of the inner kinetochore subcomplex of the centromere. It has been shown to be involved in chromosome segregation via regulation of the spindle in both yeast and human.


Pssm-ID: 430646 [Multi-domain]  Cd Length: 202  Bit Score: 41.07  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541407  124 ISTAFEGNLLDSYFVDL----VIEKPLRIHHHSVPVFIPLEKIAAAHLQT--------------DVQRFLFRLWEYLNAY 185
Cdd:pfam09496  24 IDVSSRGRFLRPYYVLLnrpsFGEKRLRVHRHTIPPFIPLSGLAARYLPApeeakkdkektpkqDLVRFVRELRRELVAY 103

                          90
                  ....*....|....
gi 755541407  186 AGRKYQADQLESDF 199
Cdd:pfam09496 104 HNRLDAVRDLREAL 117
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
28-68 9.22e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 36.81  E-value: 9.22e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 755541407  28 TNISNRKSEEPAVRKKESSLRTKIRELRQQRDKLRAEVKQW 68
Cdd:COG1340    1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKEL 41
 
Name Accession Description Interval E-value
DRWD-N_CENP-O cd23835
N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 102-182 3.80e-26

N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the N-terminal double-RWD domain (DRWD-N).


Pssm-ID: 467668  Cd Length: 86  Bit Score: 97.66  E-value: 3.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541407 102 ILEAYRFTGLSGKLT-SRGVCMCISTAFEGNLLDSYFVDLVIEKP--LRIHHHSVPVFIPLEKIAAAHLQTDVQRFLFRL 178
Cdd:cd23835    3 LLQAYRLTGRSVFEVdGNRLGVRFDTFYEGTYLESYYIDLEIKSPlsLKISRHTLPYFIPLEELEKKYLQTDLKKFLSVV 82


                 ....
gi 755541407 179 WEYL 182
Cdd:cd23835   83 SEYL 86
DRWD-C_CENP-O cd23836
C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 183-251 6.17e-16

C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the C-terminal double-RWD domain (DRWD-C).


Pssm-ID: 467669  Cd Length: 98  Bit Score: 71.18  E-value: 6.17e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755541407 183 NAYAGRKYQADQLESDFcDVLTGPLQRNALCNLLSFTYKVeqRCQTFSFSARLLYEDPTAALPTNVTVT 251
Cdd:cd23836    1 NAYVSRREQVDQLKELF-GEFVGEIEHSSAYDFISFSLKV--STGSGRFEVTLKYDDLTSELPTEVTVT 66
CENP-O pfam09496
Cenp-O kinetochore centromere component; This eukaryotic protein is a component of the inner ...
 124-199 2.41e-04

Cenp-O kinetochore centromere component; This eukaryotic protein is a component of the inner kinetochore subcomplex of the centromere. It has been shown to be involved in chromosome segregation via regulation of the spindle in both yeast and human.


Pssm-ID: 430646 [Multi-domain]  Cd Length: 202  Bit Score: 41.07  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541407  124 ISTAFEGNLLDSYFVDL----VIEKPLRIHHHSVPVFIPLEKIAAAHLQT--------------DVQRFLFRLWEYLNAY 185
Cdd:pfam09496  24 IDVSSRGRFLRPYYVLLnrpsFGEKRLRVHRHTIPPFIPLSGLAARYLPApeeakkdkektpkqDLVRFVRELRRELVAY 103

                          90
                  ....*....|....
gi 755541407  186 AGRKYQADQLESDF 199
Cdd:pfam09496 104 HNRLDAVRDLREAL 117
DRWD-N_Mcm21 cd23830
N-terminal double-RWD domain of minichromosome maintenance protein 21 (MCM21) and related ...
 143-178 1.59e-03

N-terminal double-RWD domain of minichromosome maintenance protein 21 (MCM21) and related proteins; MCM21, also called inner kinetochore subunit MCM21, CENP-O homolog, chromosome transmission fidelity protein 5 (CTF5), or constitutive centromere-associated network protein MCM21, is a component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. MCM21 contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the N-terminal double-RWD domain (DRWD-N).


Pssm-ID: 467664  Cd Length: 107  Bit Score: 37.36  E-value: 1.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 755541407 143 EKPLRIHHHSVPVFIPLEKIAAAHL------QTDVQRFLFRL 178
Cdd:cd23830   66 NKSLEVYKHTIPAFIPVQGLADRYLggtdpsKDDLRLFAREL 107
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
28-68 9.22e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 36.81  E-value: 9.22e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 755541407  28 TNISNRKSEEPAVRKKESSLRTKIRELRQQRDKLRAEVKQW 68
Cdd:COG1340    1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKEL 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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