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Conserved domains on  [gi|755516698|ref|XP_011239638|]
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leucine-rich repeat transmembrane neuronal protein 4 isoform X5 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-312 1.47e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 1.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  72 NSIQKLKSNQFAGLNQLIWLYLDHNyissvdeDAFQGIRRLKELILSSNKITYLhNKTFHPVPNLRNLDLSYNKLQTLqS 151
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-P 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 152 EQFKGLRKLIILHLRSNSLKTVPiRVFQDCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskinfAHFPRLFN 231
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-------------------------EPLGNLTN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 232 LRSIYLQWNRIRSVSQGLTwTWSSLHTLDLSGNDIQAIEpgTFKCLPNLQKLNLDSNKLTNVSQETvnAWISLISITLSG 311
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSN 281


                 .
gi 755516698 312 N 312
Cdd:COG4886  282 N 282
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-312 1.47e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 1.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  72 NSIQKLKSNQFAGLNQLIWLYLDHNyissvdeDAFQGIRRLKELILSSNKITYLhNKTFHPVPNLRNLDLSYNKLQTLqS 151
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-P 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 152 EQFKGLRKLIILHLRSNSLKTVPiRVFQDCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskinfAHFPRLFN 231
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-------------------------EPLGNLTN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 232 LRSIYLQWNRIRSVSQGLTwTWSSLHTLDLSGNDIQAIEpgTFKCLPNLQKLNLDSNKLTNVSQETvnAWISLISITLSG 311
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSN 281


                 .
gi 755516698 312 N 312
Cdd:COG4886  282 N 282
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 91-312 2.07e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.21  E-value: 2.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  91 LYLDHNYISSVDEDAFqgIRRLKELILSSNKITYLHNktFHPVPNLRNLDLSYNKLQTLqsEQFKGLRKLIILHLRSNSl 170
Cdd:cd21340    7 LYLNDKNITKIDNLSL--CKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 171 ktvpIRV---FQDCRNLDFLDLGYNRLRSlsrnafagllklkelhleHNQFskinfahfprLFNLRSIylqwnriRSVSQ 247
Cdd:cd21340   80 ----ISVvegLENLTNLEELHIENQRLPP------------------GEKL----------TFDPRSL-------AALSN 120

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755516698 248 gltwtwsSLHTLDLSGNDIQAIEPgtFKCLPNLQKLNLDSNKLTNVSQ--ETVNAWISLISITLSGN 312
Cdd:cd21340  121 -------SLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
134-194 9.57e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.71  E-value: 9.57e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755516698  134 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 194
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 56-312 4.93e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 4.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  56 IPENISGGSQGLSLRF--NSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 133
Cdd:PLN00113 276 IPPSIFSLQKLISLDLsdNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 134 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDfldlgynRLRsLSRNAFAGLLKlkelhl 213
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLR-------RVR-LQDNSFSGELP------ 421

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 214 ehNQFSKINFAHF-------------PRLFNLRSIYLQWNRIRSVSQGLTWTWSS--LHTLDLSGNDIQAIEPGTFKCLP 278
Cdd:PLN00113 422 --SEFTKLPLVYFldisnnnlqgrinSRKWDMPSLQMLSLARNKFFGGLPDSFGSkrLENLDLSRNQFSGAVPRKLGSLS 499

                        250       260       270
                 ....*....|....*....|....*....|....
gi 755516698 279 NLQKLNLDSNKLTNVSQETVNAWISLISITLSGN 312
Cdd:PLN00113 500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-312 1.47e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.87  E-value: 1.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  72 NSIQKLKSNQFAGLNQLIWLYLDHNyissvdeDAFQGIRRLKELILSSNKITYLhNKTFHPVPNLRNLDLSYNKLQTLqS 151
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-P 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 152 EQFKGLRKLIILHLRSNSLKTVPiRVFQDCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskinfAHFPRLFN 231
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-------------------------EPLGNLTN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 232 LRSIYLQWNRIRSVSQGLTwTWSSLHTLDLSGNDIQAIEpgTFKCLPNLQKLNLDSNKLTNVSQETvnAWISLISITLSG 311
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSN 281


                 .
gi 755516698 312 N 312
Cdd:COG4886  282 N 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-312 2.34e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 2.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  44 KIVYCESHAFADIPENISGGS--QGLSLRFNSIQKLkSNQFAGLNQLIWLYLDHNYISSVDEdAFQGIRRLKELILSSNK 121
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 122 ITYLHnKTFHPVPNLRNLDLSYNKLQTLqSEQFKGLRKLIILHLRSNSLKTVPirVFQDCRNLDFLDLGYNRLRSLSrnA 201
Cdd:COG4886  194 ITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP--P 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 202 FAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQ 281
Cdd:COG4886  268 LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347

                        250       260       270
                 ....*....|....*....|....*....|.
gi 755516698 282 KLNLDSNKLTNVSQETVNAWISLISITLSGN 312
Cdd:COG4886  348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-312 5.38e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 5.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  64 SQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSY 143
Cdd:COG4886   26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 144 NklqtlqsEQFKGLRKLIILHLRSNSLKTVPIRvFQDCRNLDFLDLGYNRLRSLSRNafagllklkelhlehnqfskinf 223
Cdd:COG4886  106 N-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEP----------------------- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 224 ahFPRLFNLRSIYLQWNRIRSVSQGLTwTWSSLHTLDLSGNDIQAIePGTFKCLPNLQKLNLDSNKLTNVSQEtVNAWIS 303
Cdd:COG4886  155 --LGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTN 229


                 ....*....
gi 755516698 304 LISITLSGN 312
Cdd:COG4886  230 LETLDLSNN 238
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 91-312 2.07e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.21  E-value: 2.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  91 LYLDHNYISSVDEDAFqgIRRLKELILSSNKITYLHNktFHPVPNLRNLDLSYNKLQTLqsEQFKGLRKLIILHLRSNSl 170
Cdd:cd21340    7 LYLNDKNITKIDNLSL--CKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 171 ktvpIRV---FQDCRNLDFLDLGYNRLRSlsrnafagllklkelhleHNQFskinfahfprLFNLRSIylqwnriRSVSQ 247
Cdd:cd21340   80 ----ISVvegLENLTNLEELHIENQRLPP------------------GEKL----------TFDPRSL-------AALSN 120

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755516698 248 gltwtwsSLHTLDLSGNDIQAIEPgtFKCLPNLQKLNLDSNKLTNVSQ--ETVNAWISLISITLSGN 312
Cdd:cd21340  121 -------SLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
134-194 9.57e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.71  E-value: 9.57e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755516698  134 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 194
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-266 5.97e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 5.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  44 KIVYCESHAFADIPENISGGS--QGLSLRFNSIQKLkSNQFAGLNQLIWLYLDHNYISSVDEDaFQGIRRLKELILSSNK 121
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQ 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 122 ITYLHNktFHPVPNLRNLDLSYNKLQTLQSEqfKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNA 201
Cdd:COG4886  240 LTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755516698 202 FAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDI 266
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR_8 pfam13855
Leucine rich repeat;
87-146 1.74e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.74e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698   87 QLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL 146
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
67-122 6.39e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 6.39e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755516698   67 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKI 122
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
110-170 1.23e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.23e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755516698  110 RRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSL 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
231-290 6.94e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 6.94e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  231 NLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKL 290
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
254-312 3.17e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.17e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755516698  254 SSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKLTNVSQetvNAWI---SLISITLSGN 312
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP---GAFSglpSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
158-242 8.61e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 8.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  158 RKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGllklkelhlehnqfskinfahfprLFNLRSIYL 237
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG------------------------LPSLRYLDL 56


                  ....*
gi 755516698  238 QWNRI 242
Cdd:pfam13855  57 SGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 72-269 1.43e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  72 NSIQKLKsnQFAGLNQLIWLYLDHNYISSVDEdaFQGIRRLKELILSSNKITYLHNktFHPVPNLRNLDLSYnklQTLQS 151
Cdd:cd21340   34 NKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIEN---QRLPP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 152 EQFkglrkliiLHLRSNSLKTVpirvfqdCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskiNFAHfprLFN 231
Cdd:cd21340  105 GEK--------LTFDPRSLAAL-------SNSLRVLNISGNNIDSLE-----------------------PLAP---LRN 143

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 755516698 232 LRSIYLQWNRIRSVSQ--GLTWTWSSLHTLDLSGNDIQAI 269
Cdd:cd21340  144 LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKK 183
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 56-312 4.93e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 4.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  56 IPENISGGSQGLSLRF--NSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 133
Cdd:PLN00113 276 IPPSIFSLQKLISLDLsdNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 134 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDfldlgynRLRsLSRNAFAGLLKlkelhl 213
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLR-------RVR-LQDNSFSGELP------ 421

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 214 ehNQFSKINFAHF-------------PRLFNLRSIYLQWNRIRSVSQGLTWTWSS--LHTLDLSGNDIQAIEPGTFKCLP 278
Cdd:PLN00113 422 --SEFTKLPLVYFldisnnnlqgrinSRKWDMPSLQMLSLARNKFFGGLPDSFGSkrLENLDLSRNQFSGAVPRKLGSLS 499

                        250       260       270
                 ....*....|....*....|....*....|....
gi 755516698 279 NLQKLNLDSNKLTNVSQETVNAWISLISITLSGN 312
Cdd:PLN00113 500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 85-296 7.18e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 7.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  85 LNQLIWLYLDHNYISSVDEDAFQGIRR---LKELILSSNKITYLHNKTF-----HPVPNLRNLDLSYNKLQTLQSEQ--- 153
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDRGLRLLakglkDLPPALEKLVLGRNRLEGASCEAlak 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 154 -FKGLRKLIILHLRSNSLKTVPIRV----FQDCRNLDFLDLGYNRLRSLSRNAFAGLlklkelhlehnqfskinfahFPR 228
Cdd:cd00116  160 aLRANRDLKELNLANNGIGDAGIRAlaegLKANCNLEVLDLNNNGLTDEGASALAET--------------------LAS 219

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755516698 229 LFNLRSIYLQWNRIRSV-----SQGLTWTWSSLHTLDLSGNDI------QAIEPGTFKCLpnLQKLNLDSNKLTNVSQE 296
Cdd:cd00116  220 LKSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDItddgakDLAEVLAEKES--LLELDLRGNKFGEEGAQ 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 62-312 2.79e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 2.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  62 GGSQGLSLRFNSIQKLKSNQFAGLNQLIWL---YLDHNYISSvdedafQGIRRLKE----------LILSSNKITYL--- 125
Cdd:COG5238  153 GNAVHLLGLAARLGLLAAISMAKALQNNSVetvYLGCNQIGD------EGIEELAEaltqnttvttLWLKRNPIGDEgae 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 126 -------HNKTfhpvpnLRNLDLSYNKLqtlqseqfkGLRKLIIL--HLRSNslktvpirvfqdcRNLDFLDLGYNRL-- 194
Cdd:COG5238  227 ilaealkGNKS------LTTLDLSNNQI---------GDEGVIALaeALKNN-------------TTVETLYLSGNQIga 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 195 ---RSLSrNAFAGLLKLKELHLEHNQF---SKINFA-HFPRLFNLRSIYLQWNRI-----RSVSQGLtWTWSSLHTLDLS 262
Cdd:COG5238  279 egaIALA-KALQGNTTLTSLDLSVNRIgdeGAIALAeGLQGNKTLHTLNLAYNGIgaqgaIALAKAL-QENTTLHSLDLS 356

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 755516698 263 GN---DIQAIEPGTF-KCLPNLQKLNLDSNKLTNVSQETVNAWI---SLISITLSGN 312
Cdd:COG5238  357 DNqigDEGAIALAKYlEGNTTLRELNLGKNNIGKQGAEALIDALqtnRLHTLILDGN 413
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 134-298 3.42e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 3.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 134 PNLRNLDLSYNKLQTLQSEQFKGLRK---LIILHLRSNSLKTVP----IRVFQDCR-NLDFLDLGYNRLRSLSRNAFAGL 205
Cdd:cd00116   81 CGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDRGlrllAKGLKDLPpALEKLVLGRNRLEGASCEALAKA 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 206 LKLKEL----HLEHNQFSKINFAH----FPRLFNLRSIYLQWNRIRS--VSQ--GLTWTWSSLHTLDLSGN-----DIQA 268
Cdd:cd00116  161 LRANRDlkelNLANNGIGDAGIRAlaegLKANCNLEVLDLNNNGLTDegASAlaETLASLKSLEVLNLGDNnltdaGAAA 240

                        170       180       190
                 ....*....|....*....|....*....|
gi 755516698 269 IEPGTFKCLPNLQKLNLDSNKLTNVSQETV 298
Cdd:cd00116  241 LASALLSPNISLLTLSLSCNDITDDGAKDL 270
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
87-295 4.91e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 4.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  87 QLIWLYLDHNYISSVDEDaFQGirRLKELILSSNKITYLHNKtfhpVPN-LRNLDLSYNKLQTLQSEQFKGLRKLIILHl 165
Cdd:PRK15370 200 QITTLILDNNELKSLPEN-LQG--NIKTLYANSNQLTSIPAT----LPDtIQEMELSINRITELPERLPSALQSLDLFH- 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 166 rsNSLKTVPIRVFQDCRNLDFLDlgyNRLRSLSRNAFAGLLKLkelhlehNQFSKiNFAHFPRLF--NLRSIYLQWNRIR 243
Cdd:PRK15370 272 --NKISCLPENLPEELRYLSVYD---NSIRTLPAHLPSGITHL-------NVQSN-SLTALPETLppGLKTLEAGENALT 338

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755516698 244 SVSQGLTwtwSSLHTLDLSGNDIQAIePGTFKclPNLQKLNLDSNKLTNVSQ 295
Cdd:PRK15370 339 SLPASLP---PELQVLDVSKNQITVL-PETLP--PTITTLDVSRNALTNLPE 384
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 58-312 2.36e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  58 ENISGGSQGLSLRFNSIQ--KLKSNQFAGlnqliwlyldhnyisSVDEDAFQGIRRLKELILSSNKITYLHNKTFhpVPN 135
Cdd:PLN00113  79 KNISGKISSAIFRLPYIQtiNLSNNQLSG---------------PIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPN 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 136 LRNLDLSYNKLQtlqseqfkglrkliilhlrsnslKTVP--IRVFQdcrNLDFLDLGYNRLRSLSRNAFAGLLKLKELHL 213
Cdd:PLN00113 142 LETLDLSNNMLS-----------------------GEIPndIGSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTL 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698 214 EHNQFSKINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKLTNV 293
Cdd:PLN00113 196 ASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGP 275

                        250
                 ....*....|....*....
gi 755516698 294 SQETVNAWISLISITLSGN 312
Cdd:PLN00113 276 IPPSIFSLQKLISLDLSDN 294
LRR_9 pfam14580
Leucine-rich repeat;
67-186 3.03e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 44.75  E-value: 3.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698   67 LSLRFNSIQKLKsNQFAGLNQLIWLYLDHNYISSVDedAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL 146
Cdd:pfam14580  24 LDLRGYKIPIIE-NLGATLDQFDTIDFSDNEIRKLD--GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 755516698  147 QTL-QSEQFKGLRKLIILHLRSNSLKTVP------IRVFQDCRNLDF 186
Cdd:pfam14580 101 QELgDLDPLASLKKLTFLSLLRNPVTNKPhyrlyvIYKVPQLRLLDF 147
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-194 1.69e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  77 LKSNQFAG--------LNQLIWLYLDHNYISSVDEDAFqGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQT 148
Cdd:PLN00113 435 ISNNNLQGrinsrkwdMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSG 513

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 755516698 149 LQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 194
Cdd:PLN00113 514 EIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 255-294 2.85e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 2.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 755516698  255 SLHTLDLSGNDIQAIEPgtFKCLPNLQKLNLDSN-KLTNVS 294
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNnKITDLS 40
PLN03150 PLN03150
hypothetical protein; Provisional
 227-291 1.30e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 1.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755516698 227 PRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKLT 291
Cdd:PLN03150 439 SKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 96-184 1.36e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.68  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698   96 NYISSVDEDAFQGIRRLKELILSSN---------------------KITYLHNKTFHPVPNLRNLDLSyNKLQTLQSEQF 154
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSSltsigsyafyncsltsitipsSLTSIGEYAFSNCSNLKSITLP-SNLTSIGSYAF 98

                          90       100       110
                  ....*....|....*....|....*....|..
gi 755516698  155 KG--LRKLIIlhlrSNSLKTVPIRVFQDCRNL 184
Cdd:pfam13306  99 SNcsLKSITI----PSSVTTIGSYAFSNCSNL 126
LRR_9 pfam14580
Leucine-rich repeat;
216-292 1.49e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.75  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  216 NQFSKINFA--------HFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQA---IEPgtFKCLPNLQKLN 284
Cdd:pfam14580  42 DQFDTIDFSdneirkldGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQElgdLDP--LASLKKLTFLS 119


                  ....*...
gi 755516698  285 LDSNKLTN 292
Cdd:pfam14580 120 LLRNPVTN 127
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 134-168 6.60e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 6.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 755516698  134 PNLRNLDLSYNKLQTLQSeqFKGLRKLIILHLRSN 168
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 67-146 7.03e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 7.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755516698  67 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL 146
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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