NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755500830|ref|XP_011238145|]
View 

cystatin E2 isoform X1 [Mus musculus]

Protein Classification

cystatin family protein( domain architecture ID 430)

cystatin family protein may function as a cysteine protease inhibitor, such as Glycine max cystatin that inhibits papain and cathepsin B

CATH:  3.10.450.10
Gene Ontology:  GO:0004869|GO:0010466
PubMed:  1855589|9007972|3555466|14587292
SCOP:  4001013

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 39-104 2.00e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member pfam00031:

Pssm-ID: 447698  Cd Length: 92  Bit Score: 46.17  E-value: 2.00e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755500830   39 DIVKFALSAFHKKSKDEYaYRVIHIMNFlKVQEEPPQTFFVKLRLTRTICMKFEKSLDTCPLPELQ 104
Cdd:pfam00031  15 EALDFALAEYNAKTDNYY-FELVEVKRA-KSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEK 78
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 39-104 2.00e-07

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 46.17  E-value: 2.00e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755500830   39 DIVKFALSAFHKKSKDEYaYRVIHIMNFlKVQEEPPQTFFVKLRLTRTICMKFEKSLDTCPLPELQ 104
Cdd:pfam00031  15 EALDFALAEYNAKTDNYY-FELVEVKRA-KSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEK 78
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 39-140 2.64e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 43.57  E-value: 2.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755500830    39 DIVKFALSAFHKKSKDEYAYRVIHIMNFlKVQEEPPQTFFVKLRLTRTICMKFEKSLDTCPLPELQNvrqnmsihpftvi 118
Cdd:smart00043  18 EAADFAVAEYNKKSNDKYELRVIKVVSA-KSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGE------------- 83

                           90       100
                   ....*....|....*....|...
gi 755500830   119 LICSFSI-SSPGSKQFNLLKMTC 140
Cdd:smart00043  84 KFCTAKVwEKPWENKIKLVEFKC 106
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 39-140 1.63e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 38.61  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755500830  39 DIVKFALSAFHKKSKDEYaYRVIHIMNFlKVQEEPPQTFFVKLRLTRTICMKFEKSLDT--CPLPELQnvrqnmsihpft 116
Cdd:cd00042   15 ELADFAVAEYNKKSNDKY-LEFFKVLSA-KSQVVAGTNYYITVEAGDTNCKKSSVPLDCpdCKLLEEG------------ 80

                         90       100
                 ....*....|....*....|....*
gi 755500830 117 VILICSFSISS-PGSKQFNLLKMTC 140
Cdd:cd00042   81 KKKFCTAKVWEkPWENFKELLSFKC 105
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 39-104 2.00e-07

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 46.17  E-value: 2.00e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755500830   39 DIVKFALSAFHKKSKDEYaYRVIHIMNFlKVQEEPPQTFFVKLRLTRTICMKFEKSLDTCPLPELQ 104
Cdd:pfam00031  15 EALDFALAEYNAKTDNYY-FELVEVKRA-KSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEK 78
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 39-140 2.64e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 43.57  E-value: 2.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755500830    39 DIVKFALSAFHKKSKDEYAYRVIHIMNFlKVQEEPPQTFFVKLRLTRTICMKFEKSLDTCPLPELQNvrqnmsihpftvi 118
Cdd:smart00043  18 EAADFAVAEYNKKSNDKYELRVIKVVSA-KSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGE------------- 83

                           90       100
                   ....*....|....*....|...
gi 755500830   119 LICSFSI-SSPGSKQFNLLKMTC 140
Cdd:smart00043  84 KFCTAKVwEKPWENKIKLVEFKC 106
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 39-140 1.63e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 38.61  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755500830  39 DIVKFALSAFHKKSKDEYaYRVIHIMNFlKVQEEPPQTFFVKLRLTRTICMKFEKSLDT--CPLPELQnvrqnmsihpft 116
Cdd:cd00042   15 ELADFAVAEYNKKSNDKY-LEFFKVLSA-KSQVVAGTNYYITVEAGDTNCKKSSVPLDCpdCKLLEEG------------ 80

                         90       100
                 ....*....|....*....|....*
gi 755500830 117 VILICSFSISS-PGSKQFNLLKMTC 140
Cdd:cd00042   81 KKKFCTAKVWEkPWENFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH