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Conserved domains on  [gi|719998953|ref|XP_010255563|]
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PREDICTED: SPX domain-containing membrane protein At4g22990 [Nelumbo nucifera]

Protein Classification

SPX domain-containing membrane protein( domain architecture ID 12997668)

SPX domain-containing membrane protein with a major facilitator superfamily (MFS) transporter domain may function in phosphate homeostasis and in the transport across cytoplasmic or internal membranes various substrates including sugar phosphates

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  22403821|26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPX-MFS_plant cd14479
SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; ...
 2-141 1.58e-91

SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The SPX domain is found at the amino terminus of a variety of proteins. This family, mostly found in plants, contains a C-terminal MFS domain (major facilitator superfamily), suggesting a function as a secondary transporter. The function of this N-terminal region is unclear, although it might be involved in regulating transport.


:

Pssm-ID: 269900 [Multi-domain]  Cd Length: 140  Bit Score: 280.71  E-value: 1.58e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   2 VAFGKKLKERQIQEWQGYYINYKLMKKKVKQYSQQMQVGAQDRRHVLKEFSRMLDTQIEKIVLFLLEQQGLLASRLAKLG 81
Cdd:cd14479    1 VNFGKKLKEDQIPEWEGYYINYKLLKKKVKQYVQQTQDGGQDRRDVLKDFSKLLDDQIEKIVLFLLEQQGLLASRLEKLG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  82 EQRTALLEQPDISQISDLRESYRAVGQDLLKLLFFVEMNAIGIRKILKKFDKRFGYRFTD 141
Cdd:cd14479   81 EQREALQEQPDLSQISELREAYRAVGLDLLKLLKFVELNATGLRKILKKFDKRFGYRFTD 140
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 247-655 5.90e-24

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17326:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 374  Bit Score: 104.21  E-value: 5.90e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 247 FMSLILNLANTFLYMvntyIIVPTADnySLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK--SYFRPLVFSSIVLLV 324
Cdd:cd17326    6 LTMFLSSLQFSIVLT----SIWPYLQ--KIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKtsSVKEPLIVSILIAIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 325 GNTLYALAYDF--NSLAVLLIGRLFCGLG-SARAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQT---- 397
Cdd:cd17326   80 GNILYALAEYFpsNRKYVMLVARFLIGVGaGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPigyp 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 398 -RFKIYKITFNEDTLPGWVMALAWLFYLLWLWISFKEpsheshennvaqqvsteavesklengltkplllsseekerded 476
Cdd:cd17326  160 gYVIGIKLRFNMYTAPAWLMAILGIINIILILFFFKE------------------------------------------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 477 ddqevdgseeapeeshrpatsiasayhlltpsvkVQLLIYFMLKYAMEILL-SESSVITTYYFGWT----TSSVAIFLAC 551
Cdd:cd17326  197 ----------------------------------VVCIFLFFVVLFIFANLeTIGTPLTMDMYGWTreeaVLYNGIILAV 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 552 LGLTVLPVNIVVGSYISNMFEDRQILLASEVMVCIG--ILLSFHIIspysvpqyvfSALVTFVAAEVLEGVNLSLLSRVM 629
Cdd:cd17326  243 SGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGfvVTLPWGIT----------GVILFGLGYPIGNVMLYTLYSKIL 312

                        410       420
                 ....*....|....*....|....*.
gi 719998953 630 SSRlARGTYNGGLlsTEAGTLARVVA 655
Cdd:cd17326  313 GPK-PQGTMQGVL--TASGSLARTLG 335
 
Name Accession Description Interval E-value
SPX-MFS_plant cd14479
SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; ...
 2-141 1.58e-91

SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The SPX domain is found at the amino terminus of a variety of proteins. This family, mostly found in plants, contains a C-terminal MFS domain (major facilitator superfamily), suggesting a function as a secondary transporter. The function of this N-terminal region is unclear, although it might be involved in regulating transport.


Pssm-ID: 269900 [Multi-domain]  Cd Length: 140  Bit Score: 280.71  E-value: 1.58e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   2 VAFGKKLKERQIQEWQGYYINYKLMKKKVKQYSQQMQVGAQDRRHVLKEFSRMLDTQIEKIVLFLLEQQGLLASRLAKLG 81
Cdd:cd14479    1 VNFGKKLKEDQIPEWEGYYINYKLLKKKVKQYVQQTQDGGQDRRDVLKDFSKLLDDQIEKIVLFLLEQQGLLASRLEKLG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  82 EQRTALLEQPDISQISDLRESYRAVGQDLLKLLFFVEMNAIGIRKILKKFDKRFGYRFTD 141
Cdd:cd14479   81 EQREALQEQPDLSQISELREAYRAVGLDLLKLLKFVELNATGLRKILKKFDKRFGYRFTD 140
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 247-655 5.90e-24

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 104.21  E-value: 5.90e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 247 FMSLILNLANTFLYMvntyIIVPTADnySLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK--SYFRPLVFSSIVLLV 324
Cdd:cd17326    6 LTMFLSSLQFSIVLT----SIWPYLQ--KIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKtsSVKEPLIVSILIAIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 325 GNTLYALAYDF--NSLAVLLIGRLFCGLG-SARAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQT---- 397
Cdd:cd17326   80 GNILYALAEYFpsNRKYVMLVARFLIGVGaGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPigyp 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 398 -RFKIYKITFNEDTLPGWVMALAWLFYLLWLWISFKEpsheshennvaqqvsteavesklengltkplllsseekerded 476
Cdd:cd17326  160 gYVIGIKLRFNMYTAPAWLMAILGIINIILILFFFKE------------------------------------------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 477 ddqevdgseeapeeshrpatsiasayhlltpsvkVQLLIYFMLKYAMEILL-SESSVITTYYFGWT----TSSVAIFLAC 551
Cdd:cd17326  197 ----------------------------------VVCIFLFFVVLFIFANLeTIGTPLTMDMYGWTreeaVLYNGIILAV 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 552 LGLTVLPVNIVVGSYISNMFEDRQILLASEVMVCIG--ILLSFHIIspysvpqyvfSALVTFVAAEVLEGVNLSLLSRVM 629
Cdd:cd17326  243 SGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGfvVTLPWGIT----------GVILFGLGYPIGNVMLYTLYSKIL 312

                        410       420
                 ....*....|....*....|....*.
gi 719998953 630 SSRlARGTYNGGLlsTEAGTLARVVA 655
Cdd:cd17326  313 GPK-PQGTMQGVL--TASGSLARTLG 335
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
241-644 1.37e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 84.64  E-value: 1.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 241 DDQRYNFMSLILNLANTFLYMVNTYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK-SYFRPLVFSS 319
Cdd:COG2814    3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRfGRRRVLLLGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 320 IVLLVGNTLYALAydfNSLAVLLIGRLFCGLGSA--RAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQT 397
Cdd:COG2814   83 LLFALGSLLCALA---PSLWLLLAARFLQGLGAGalFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 398 RFkIYKITFnedtlpgWVMALAWLFYLLWLWISFKEPsheshennvaqqvsteavesklengltkplllsseekerdedd 477
Cdd:COG2814  160 LF-GWRWVF-------LVNAVLALLALLLLLRLLPES------------------------------------------- 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 478 dqevdgseeAPEESHRPATSIASAyhLLTPSVKVQLLIYFMLKYAMEILLSESSVITTYYFGWTTSSVAIFLACLGLTVL 557
Cdd:COG2814  189 ---------RPAARARLRGSLREL--LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 558 PVNIVVGsYISNMFEDRQILLASEVMVCIGILLSFHIISPYSVpqyVFSALVTFVAAEVLEGVNLSLLSRVMSSRlARGT 637
Cdd:COG2814  258 LGALLAG-RLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLL---LLALFLLGFGFGLLFPLLQALVAELAPPE-ARGR 332


                 ....*..
gi 719998953 638 YNGGLLS 644
Cdd:COG2814  333 ASGLYNS 339
MFS_1 pfam07690
Major Facilitator Superfamily;
257-640 9.07e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 63.98  E-value: 9.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  257 TFLYMVNTYIIVPTADNY-SLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRP-LVFSSIVLLVGNTLYALAyd 334
Cdd:pfam07690   5 AFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRvLLIGLLLFALGLLLLLFA-- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  335 fNSLAVLLIGRLFCGLGSA--RAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRFkIYKITFnedtlp 412
Cdd:pfam07690  83 -SSLWLLLVLRVLQGLGAGalFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAF------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  413 gWVMALAWLFYLLWLWISFKEPSHeshennvaqqvsteavesklengltkplllsseekerdedddqevdgseEAPEESH 492
Cdd:pfam07690 155 -LILAILSLLAAVLLLLPRPPPES-------------------------------------------------KRPKPAE 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  493 RPATSIASAYHLLTPSVKVQLLIYFMLKYAMEILLSESSVITTYYFGWTTSSVAIFLACLGLTVLPVNIVVGSYISNMFE 572
Cdd:pfam07690 185 EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR 264

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 719998953  573 DRQILLASEVMVCIGILLSFHIISPYSVPQYVFSALVTFVAAeVLEGVNLSLLSRVMSSRLaRGTYNG 640
Cdd:pfam07690 265 RRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFG-LVFPALNALVSDLAPKEE-RGTASG 330
SPX pfam03105
SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 ...
 108-143 1.06e-06

SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 residue long domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2 NUC-2 contains several ankyrin repeats pfam00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine xenotropic and polytropic leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signalling and result in cell toxicity and death. The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organizms. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor.


Pssm-ID: 460807 [Multi-domain]  Cd Length: 339  Bit Score: 51.41  E-value: 1.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 719998953  108 QDLLKLLFFVEMNAIGIRKILKKFDKRFGYRFTDYY 143
Cdd:pfam03105 300 RGLELLKSYSELNRTAFRKILKKFDKVTSLNASKDY 335
 
Name Accession Description Interval E-value
SPX-MFS_plant cd14479
SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; ...
 2-141 1.58e-91

SPX domain of proteins found in plants and stramenopiles; most have a C-terminal MFS domain; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The SPX domain is found at the amino terminus of a variety of proteins. This family, mostly found in plants, contains a C-terminal MFS domain (major facilitator superfamily), suggesting a function as a secondary transporter. The function of this N-terminal region is unclear, although it might be involved in regulating transport.


Pssm-ID: 269900 [Multi-domain]  Cd Length: 140  Bit Score: 280.71  E-value: 1.58e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   2 VAFGKKLKERQIQEWQGYYINYKLMKKKVKQYSQQMQVGAQDRRHVLKEFSRMLDTQIEKIVLFLLEQQGLLASRLAKLG 81
Cdd:cd14479    1 VNFGKKLKEDQIPEWEGYYINYKLLKKKVKQYVQQTQDGGQDRRDVLKDFSKLLDDQIEKIVLFLLEQQGLLASRLEKLG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  82 EQRTALLEQPDISQISDLRESYRAVGQDLLKLLFFVEMNAIGIRKILKKFDKRFGYRFTD 141
Cdd:cd14479   81 EQREALQEQPDLSQISELREAYRAVGLDLLKLLKFVELNATGLRKILKKFDKRFGYRFTD 140
SPX cd14447
Domain found in Syg1, Pho81, XPR1, and related proteins; This region has been named the SPX ...
 4-133 5.70e-29

Domain found in Syg1, Pho81, XPR1, and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). This domain is found at the amino terminus of a variety of proteins. In the yeast protein Syg1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors Pho81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2. NUC-2 contains several ankyrin repeats. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with xenotropic and polytropic murine leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signaling and result in cell toxicity and death. The similarity between Syg1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, S. cerevisiae, and many other diverse organisms.


Pssm-ID: 269894 [Multi-domain]  Cd Length: 143  Bit Score: 112.66  E-value: 5.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   4 FGKKLKERQIQEWQGYYINYKLMKKKVKQY----------SQQMQVGAQDRRHVLKEFSRMLDTQIEKIVLF---LLEQQ 70
Cdd:cd14447    2 FGKRLREEAVPEWRDKYVDYKALKKLIKNLvasadeasnsSEALELSESGGEEFESEFFEALDAELEKVNEFyqeLLEEL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 719998953  71 GLLASRLAKLgEQRTALLEQPDISQISDLRESYRAVGQDLLKLLFFVEMNAIGIRKILKKFDK 133
Cdd:cd14447   82 QELLKRLEAL-EPDLPALRGSLKEELEDLRKELVESYSELEELERFVELNYTAFRKILKKYDK 143
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 247-655 5.90e-24

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 104.21  E-value: 5.90e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 247 FMSLILNLANTFLYMvntyIIVPTADnySLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK--SYFRPLVFSSIVLLV 324
Cdd:cd17326    6 LTMFLSSLQFSIVLT----SIWPYLQ--KIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKtsSVKEPLIVSILIAIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 325 GNTLYALAYDF--NSLAVLLIGRLFCGLG-SARAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQT---- 397
Cdd:cd17326   80 GNILYALAEYFpsNRKYVMLVARFLIGVGaGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPigyp 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 398 -RFKIYKITFNEDTLPGWVMALAWLFYLLWLWISFKEpsheshennvaqqvsteavesklengltkplllsseekerded 476
Cdd:cd17326  160 gYVIGIKLRFNMYTAPAWLMAILGIINIILILFFFKE------------------------------------------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 477 ddqevdgseeapeeshrpatsiasayhlltpsvkVQLLIYFMLKYAMEILL-SESSVITTYYFGWT----TSSVAIFLAC 551
Cdd:cd17326  197 ----------------------------------VVCIFLFFVVLFIFANLeTIGTPLTMDMYGWTreeaVLYNGIILAV 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 552 LGLTVLPVNIVVGSYISNMFEDRQILLASEVMVCIG--ILLSFHIIspysvpqyvfSALVTFVAAEVLEGVNLSLLSRVM 629
Cdd:cd17326  243 SGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGfvVTLPWGIT----------GVILFGLGYPIGNVMLYTLYSKIL 312

                        410       420
                 ....*....|....*....|....*.
gi 719998953 630 SSRlARGTYNGGLlsTEAGTLARVVA 655
Cdd:cd17326  313 GPK-PQGTMQGVL--TASGSLARTLG 335
SPX_PHO81_NUC-2_like cd14483
SPX domain of Pho81, NUC-2, and similar proteins; This region has been named the SPX domain ...
 4-134 3.93e-21

SPX domain of Pho81, NUC-2, and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors Pho81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. NUC-2 plays an important role in the phosphate-regulated signal transduction pathway in N. crassa. It shows high similarity to a cyclin-dependent kinase inhibitory protein Pho81, which is part of the phosphate regulatory cascade in S. cerevisiae. Both, NUC-2 and Pho81, have multi-domain architecture, including the SPX N-terminal domain following by several ankyrin repeats and a putative C-terminal glycerophosphodiester phosphodiesterase domain (GDPD) with unknown function.


Pssm-ID: 269904 [Multi-domain]  Cd Length: 162  Bit Score: 90.77  E-value: 3.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   4 FGKKLKERQIQ--EWQGYYINYKLMKKKVKQYS-----------------QQMQVGAQDRRHVLKE----FSRMLDTQIE 60
Cdd:cd14483    2 FGKYIQARQLElpEYSAYFLDYKALKKLIKSLAaprvaaaaallaggrplSPDGTDESDAQTSLQAnkaaFFFKLERELE 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 719998953  61 KIVLFLLEQQGLLASRLAKLGEQRTALLE-----QPDISQISDLRESYRAVGQDLLKLLFFVEMNAIGIRKILKKFDKR 134
Cdd:cd14483   82 KVNAFYLQKEAELKLRLDTLLDKKRVLQSrgklaSKKSASFVTLEEGFRQFERDLNKLQQFVELNATGFSKILKKWDKR 160
SPX_GDE1_like cd14484
SPX domain of Gde1 and similar proteins; This region has been named the SPX domain after (Syg1, ...
 4-136 3.06e-19

SPX domain of Gde1 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors Pho81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The yeast protein Gde1/Ypl110c is similar to both, NUC-2 and Pho81, in sharing their multi-domain architecture, which includes the SPX N-terminal domain followed by several ankyrin repeats and a C-terminal glycerophosphodiester phosphodiesterase domain (GDPD). Gde1 hydrolyzes intracellular glycerophosphocholine into glycerolphosphate and choline, and plays a role in the utilization of glycerophosphocholine as a source for phosphate.


Pssm-ID: 269905 [Multi-domain]  Cd Length: 134  Bit Score: 84.12  E-value: 3.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   4 FGKKLKERQIQEWQGYYINYKLMKKKVKQYSQQMQVGAQDRrhvLKEFSRMLDTQIEKIVLFLLEQQGLLASRLAKLGE- 82
Cdd:cd14484    2 FGKNLPRNQVPEWSSSYINYKGLKKLIKAIAEQQKEGVKVD---LAEFFFALDRNLEDVDTFYNKKFAEYSRRLKLLLDr 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 719998953  83 -QRTALLEQPD--------ISQISDLRESYRavgqdllKLLFFVEMNAIGIRKILKKFDKRFG 136
Cdd:cd14484   79 yGFSPDLVQNLdsdeleelMGALLELRSQLR-------NLQWFGELNRRGFVKILKKLDKKVP 134
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
241-644 1.37e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 84.64  E-value: 1.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 241 DDQRYNFMSLILNLANTFLYMVNTYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK-SYFRPLVFSS 319
Cdd:COG2814    3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRfGRRRVLLLGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 320 IVLLVGNTLYALAydfNSLAVLLIGRLFCGLGSA--RAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQT 397
Cdd:COG2814   83 LLFALGSLLCALA---PSLWLLLAARFLQGLGAGalFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 398 RFkIYKITFnedtlpgWVMALAWLFYLLWLWISFKEPsheshennvaqqvsteavesklengltkplllsseekerdedd 477
Cdd:COG2814  160 LF-GWRWVF-------LVNAVLALLALLLLLRLLPES------------------------------------------- 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 478 dqevdgseeAPEESHRPATSIASAyhLLTPSVKVQLLIYFMLKYAMEILLSESSVITTYYFGWTTSSVAIFLACLGLTVL 557
Cdd:COG2814  189 ---------RPAARARLRGSLREL--LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 558 PVNIVVGsYISNMFEDRQILLASEVMVCIGILLSFHIISPYSVpqyVFSALVTFVAAEVLEGVNLSLLSRVMSSRlARGT 637
Cdd:COG2814  258 LGALLAG-RLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLL---LLALFLLGFGFGLLFPLLQALVAELAPPE-ARGR 332


                 ....*..
gi 719998953 638 YNGGLLS 644
Cdd:COG2814  333 ASGLYNS 339
SPX_VTC2_like cd14480
SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; This region has been ...
 4-133 2.76e-14

SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. Vtc2 is part of the Saccharomyces cerevisiae membrane-integral VTC complex, together with Vtc1, Vtc3, and Vtc4. It contains an N-terminal SPX domain next to a central polyphosphate polymerase domain and a C-terminal domain of unknown function.


Pssm-ID: 269901 [Multi-domain]  Cd Length: 135  Bit Score: 70.26  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   4 FGKKLKERQIQEWQGYYINYKLMKKKVKQYSQQMQVGAQDRRhvlKEFSRMLDTQIEKIVLFLLEQQGLLASRLAKLGEQ 83
Cdd:cd14480    2 FGKTLKSSIYPPWKDYYIDYDKLKKLLKERETDRGWWTEDDE---RFFVELLEVELEKVYTFQKEKYSELRRRIDACEKK 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 719998953  84 RTALLEQPDISQISDLRESYRAVGQDLLKLLF-------FVEMNAIGIRKILKKFDK 133
Cdd:cd14480   79 VKELVSNLDSSEDDPSEEDFKELEEELDDILAdvhdlakFTRLNYTGFLKIVKKHDK 135
SPX_SYG1_like cd14475
SPX domain of the yeast plasma protein Syg1 and related proteins; This region has been named ...
 4-133 5.80e-14

SPX domain of the yeast plasma protein Syg1 and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. In the yeast protein Syg1, the N-terminus binds directly to the G-protein beta subunit and inhibits transduction of the mating pheromone signal, and it co-occurs with a C-terminal domain from the EXS family.


Pssm-ID: 269896 [Multi-domain]  Cd Length: 139  Bit Score: 69.52  E-value: 5.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   4 FGKKLKERQIQEWQGYYINYKLMKKKVKQysqqmqvgaqdrrhvlKEFSRMLDTQIEKIVLFLLEQQ-------GLLASR 76
Cdd:cd14475    2 FAKYLEENLVPEWRKKYLDYKGGKKKIKA----------------REFFEFLDSELDKVESFYKEKEdearerlDLLRDQ 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 719998953  77 LAKLGEQRTAL--------------LEQPDIS------QISD-LRESYRAVgqDLLKLlfFVEMNAIGIRKILKKFDK 133
Cdd:cd14475   66 LHELRDHRIQEaddgrrdysrrpeqNAHDPVSyrsarrKLKKaLQEYYRGL--ELLKS--YRLLNRTAFRKINKKFDK 139
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 258-655 1.78e-13

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 72.23  E-value: 1.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 258 FLYMVNTYIIVPTADNYS---LSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRP-LVFSSIVLLVGNTLYALAy 333
Cdd:cd17330    6 FLDALGFGIVFPVLPFYVrefNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPvLLLSLAGSAVSYVLLGLS- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 334 dfNSLAVLLIGRLFCGLGSAR-AVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRFKIYkitfnedtLP 412
Cdd:cd17330   85 --RNLWLLFLARFLDGLTGGNvSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYA--------LP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 413 GWVMALAWLFYLLWLWisfkepsheshennvaqqvsteavesklengltkplllsseekerdedddqevdgseeapeesh 492
Cdd:cd17330  155 FLVAAALALLNLVLVL---------------------------------------------------------------- 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 493 rpatsiasayhLLTPSVKVQLLIYFMLKYAMEILLSESSVITTYYFGWTTSSVAIFLACLGLTVLPVNIVVGSYISNMFE 572
Cdd:cd17330  171 -----------FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLG 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 573 DRQILLASEVMVCIGILLsfhiISPYSVPQYVFSALVTFVAAEVLEG-VNLSLLSRVMSSRlARGTYNGGLLSteAGTLA 651
Cdd:cd17330  240 ERKLLRLGLLLAIIGLLL----LPFASSVPLLVLAAAILAFGTGIVFpALSALLSKSVPSK-EQGKAQGIIQS--LQSLA 312


                 ....
gi 719998953 652 RVVA 655
Cdd:cd17330  313 RIIG 316
SPX_AtSPX1_like cd14481
SPX domain of the plant protein SPX1 and similar proteins; This region has been named the SPX ...
 4-134 2.59e-13

SPX domain of the plant protein SPX1 and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. This family of plant proteins contains a single SPX domain. Arabidopsis thaliana SPX1 and SPX3 have been reported to play roles in the adaptation to low-phosphate conditions, SPX3 may be involved in the regulation of SPX1 activity. Oryza sativa SPX1 suppresses the regulation of expression of OsPT2, a low-affinity phosphate transporter, by the MYB-like OsPHR2.


Pssm-ID: 269902 [Multi-domain]  Cd Length: 149  Bit Score: 67.68  E-value: 2.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   4 FGKKLKeRQIQ----EWQGYYINYKLMKKKVK---QYSQQMQVGAQDRRHV---------LKEFSRMLDTQIEKIVLFLL 67
Cdd:cd14481    2 FGKSLK-RQIEetlpEWRDKFLSYKELKKLLKlisPGNADKPNSKRDRRGGgaaramtkeEADFVRLLNAELDKFNAFFV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 719998953  68 EQQGLLASRLAKLGEQRTALLEQPDISqisdlRESYRAVGQDLLK-------LLFFVEMNAIGIRKILKKFDKR 134
Cdd:cd14481   81 EKEEEYVIRLKELQDRVAEAKETPRDS-----NEELMRIRREIVDfhgemvlLENYSSLNYTGLVKILKKYDKR 149
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 254-468 5.07e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.07  E-value: 5.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 254 LANTFLYMVNTYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK-SYFRPLVFSSIVLLVGNTLYALA 332
Cdd:cd17325    2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRfGRKRLLLLGLLLLAVSTLLFAFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 333 ydfNSLAVLLIGRLFCGLGSARA--VNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRFKiYKITFnedt 410
Cdd:cd17325   82 ---TSYWQLLLARFLQGLASAAVwpAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPF---- 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 719998953 411 lpgWVMALAWLFYLLWLWISFKEPSHESHENNVAQQVSTEAVESKLENGLTKPLLLSS 468
Cdd:cd17325  154 ---LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAI 208
SPX_PHO1_like cd14476
SPX domain of the plant protein PHOSPHATE1 (PHO1); This region has been named the SPX domain ...
 4-133 2.57e-11

SPX domain of the plant protein PHOSPHATE1 (PHO1); This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The PHO1 gene family conserved in plants is involved in a variety of processes, most notably the transport of inorganic phosphate from the root to the shoot of the plant and mediating the response to low levels of inorganic phosphate. More recently it has become evident that PHO1 gene families have diverged in various plants and may play roles in stress response as well as the stomatal response to abscisic acid.


Pssm-ID: 269897 [Multi-domain]  Cd Length: 139  Bit Score: 61.89  E-value: 2.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   4 FGKKLKERQIQEWQGYYINYKLMKKKVKQ--------YSQQMQVGAQDRRHVLkEFSRMLDTQIEKIVLFLLEQQGLLAS 75
Cdd:cd14476    2 FGKEFESQMVPEWQEAYVDYKQLKKDLKRiqkfrdeyETTFLEAAEEGGEYEL-VFFRRLDDELNKVNKFYRSKVEEVLK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 719998953  76 RLAKLGEQRTALLEQPDISQISDLresYRAVGqdLLKLLFFveMNAIGIRKILKKFDK 133
Cdd:cd14476   81 EAAALNKQMDALIAFRVKVENPQF---YRKLR--LLKSYSF--LNMLAFSKILKKYDK 131
MFS_1 pfam07690
Major Facilitator Superfamily;
257-640 9.07e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 63.98  E-value: 9.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  257 TFLYMVNTYIIVPTADNY-SLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRP-LVFSSIVLLVGNTLYALAyd 334
Cdd:pfam07690   5 AFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRvLLIGLLLFALGLLLLLFA-- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  335 fNSLAVLLIGRLFCGLGSA--RAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRFkIYKITFnedtlp 412
Cdd:pfam07690  83 -SSLWLLLVLRVLQGLGAGalFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAF------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  413 gWVMALAWLFYLLWLWISFKEPSHeshennvaqqvsteavesklengltkplllsseekerdedddqevdgseEAPEESH 492
Cdd:pfam07690 155 -LILAILSLLAAVLLLLPRPPPES-------------------------------------------------KRPKPAE 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  493 RPATSIASAYHLLTPSVKVQLLIYFMLKYAMEILLSESSVITTYYFGWTTSSVAIFLACLGLTVLPVNIVVGSYISNMFE 572
Cdd:pfam07690 185 EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR 264

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 719998953  573 DRQILLASEVMVCIGILLSFHIISPYSVPQYVFSALVTFVAAeVLEGVNLSLLSRVMSSRLaRGTYNG 640
Cdd:pfam07690 265 RRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFG-LVFPALNALVSDLAPKEE-RGTASG 330
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 252-399 1.09e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 63.77  E-value: 1.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 252 LNLANTFLYMVNtYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK-SYFRPLVFSSIVLLVGNTLYA 330
Cdd:cd17489    1 ILLANFFFFLSF-YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRfGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 719998953 331 LAydfNSLAVLLIGRLFCGLG--SARAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRF 399
Cdd:cd17489   80 LA---TSVALLLVLRLIHGIGwgAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL 147
SPX_PHO87_PHO90_like cd14478
SPX domain of the phosphate transporters Pho87, Pho90, Pho91, and related proteins; This ...
 15-133 1.36e-10

SPX domain of the phosphate transporters Pho87, Pho90, Pho91, and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The SPX domain of the Saccharomyces cerevisiae membrane-localized low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2. Pho91 is involved in the export of inorganic phosphate from the vacuole to the cytosol. While both, Pho87 and Pho90, transport phosphate into the cell, only Pho87 appears to also function as a sensor for high extracellular phosphate concentrations.


Pssm-ID: 269899 [Multi-domain]  Cd Length: 148  Bit Score: 59.86  E-value: 1.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  15 EWQGYYINYKLMKKKV----KQYSQQMQVGAQDRRHVL------------KEFSRMLDTQIEKIVLFLLEQQGLLASRLA 78
Cdd:cd14478   13 EWSDHYIAYSNLKKLIyqleKDQLQLQNGGDDEEEEESsllllstdedpdDVFVRALDKELEKIDSFYKEKEAELYAEVD 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 719998953  79 KLgeqRTALLEQPDISQISDLRESYRAVGQDL------LKLlfFVEMNAIGIRKILKKFDK 133
Cdd:cd14478   93 EL---LKDVEEFEEENYLYDSRISLKKRIINLyvslseLKS--YIELNRTGFSKILKKYDK 148
SPX_YDR089W cd14474
SPX domain of the yeast protein YDR089W and related proteins; This region has been named the ...
 4-133 5.24e-09

SPX domain of the yeast protein YDR089W and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The uncharacterized yeast protein YDR089W has not been shown to be involved in phosphate homeostasis, in contrast to most of the other SPX-domain containing proteins.


Pssm-ID: 269895 [Multi-domain]  Cd Length: 144  Bit Score: 55.32  E-value: 5.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   4 FGKKLKERQIQEWQGYYINYKLMKKKVKQYSQQMQVGAQD----RRHVLKEFSRMLDTQIEKIVLFLLEQQGLLASRLAK 79
Cdd:cd14474    2 FGEQLLQRSVPEWKLYNIDYNELKHLIKEHTTRDQGTAIAipsaLEKFEDSLYNEFCEQFDRVNLFVSSKADEISRRLEH 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 719998953  80 LGEQRTALLEQPDISQISDLRESYRA---------VGQDLLKLLFFVEMNAIGIRKILKKFDK 133
Cdd:cd14474   82 LESSILRLLERSASNSGSRRRQKRRLakieqellrCGEELQKLSRFIIAQKIAFRKILKKYKK 144
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 250-441 1.56e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 57.24  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 250 LILNLANTF-LYMVNTYIIVPTADNYSLSLGAAatvcGVVIGSMAVAQVFSSVYFSAWSNKSYFRPLVFSSIVLLVGntL 328
Cdd:cd17329    5 LIGSFLNRLgFFMVWPFMAIYLHQQLGLSASIV----GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL--G 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 329 YALAYDFNSLAVLLIGRLFCGLGSA--RAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLqtrfkiYKITF 406
Cdd:cd17329   79 FALLGFAHSPWLFAIALVLTGFGGGlfEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL------LLYSF 152

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 719998953 407 NedtLPGWVMALAWLFYLLWLWISFKEPSHESHEN 441
Cdd:cd17329  153 R---LLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 266-395 3.88e-08

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 55.70  E-value: 3.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 266 IIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRPLVFSSIVL-LVGNTLYALAydfNSLAVLLIG 344
Cdd:cd17390   14 MILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLtALGYVLLGFS---TSLALLFLS 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 719998953 345 RLFCGL-GSARAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLL 395
Cdd:cd17390   91 RIPLGIfKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHL 142
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 249-429 1.40e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.12  E-value: 1.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 249 SLILNLANTFLYMVNTYIIVPTADNYSLSLGAA-ATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRPLVFSSIVLLVGnT 327
Cdd:cd17325  200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLsPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV-A 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 328 LYALAYdFNSLAVLLIGRLFCGLGSA--RAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRFkIYKIT 405
Cdd:cd17325  279 LLLLPL-ATSFWLLLLLLALLGLGLGlvFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATP 356

                        170       180
                 ....*....|....*....|....
gi 719998953 406 FnedtlpgWVMALAWLFYLLWLWI 429
Cdd:cd17325  357 F-------LAAAALLLLAAVLFLL 373
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 276-590 4.05e-07

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 52.64  E-value: 4.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 276 LSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRP-LVFSSIVLLVGNTLYALAydfNSLAVLLIGRLFCGL-GSA 353
Cdd:cd17388   31 GDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPvLLLSLAGAALDYLLMAFA---PTLWWLYLGRIIAGItGAT 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 354 RAVNRRYISDCVPVKIRMQAsAGFVSAS-ALGMACGPALAGLL---QTRfkiykitfnedtLPGWVMA----LAWLFYLL 425
Cdd:cd17388  108 GAVAAAYIADVTPPEQRARN-FGLLGAAfGLGFIAGPALGGLLgeiSPR------------APFLVAAglngLNFLLGLF 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 426 WLwisfkepsHESH--ENNVAqqvsteavesklengltkplllsseekerdedddqevdgseeAPEESHRPATSIASAYH 503
Cdd:cd17388  175 VL--------PESLppERRRA------------------------------------------FRWRRANPFGSLRWLTG 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 504 LltPSVKVQLLIYFMLKYAMEILLSESSVITTYYFGWTTSSVAIFLACLGLTVLPVNIVVGSYISNMFEDRQILLASEVM 583
Cdd:cd17388  205 F--PGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAA 282


                 ....*..
gi 719998953 584 VCIGILL 590
Cdd:cd17388  283 DALGFLL 289
SPX pfam03105
SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 ...
 108-143 1.06e-06

SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 residue long domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2 NUC-2 contains several ankyrin repeats pfam00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine xenotropic and polytropic leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signalling and result in cell toxicity and death. The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organizms. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor.


Pssm-ID: 460807 [Multi-domain]  Cd Length: 339  Bit Score: 51.41  E-value: 1.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 719998953  108 QDLLKLLFFVEMNAIGIRKILKKFDKRFGYRFTDYY 143
Cdd:pfam03105 300 RGLELLKSYSELNRTAFRKILKKFDKVTSLNASKDY 335
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 250-395 3.12e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.86  E-value: 3.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 250 LILNLAnTFLYMVNTYIIVP----TADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKsyfRPLVFSSIVLLVG 325
Cdd:cd17324    2 LALALA-AFAIGTTEYVIQGllpdIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERR---RLLLVLLLLFILG 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 719998953 326 NTLYALAYDFnslAVLLIGRLFCGLGSA--RAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLL 395
Cdd:cd17324   78 NLLAALAPSF---ALLLLARALAGLAHGgfWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL 146
SPX pfam03105
SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 ...
 4-32 4.44e-06

SPX domain; We have named this region the SPX domain after SYG1, Pho81 and XPR1. This 180 residue long domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G-protein beta subunit and inhibits transduction of the mating pheromone signal. Similarly, the N-terminus of the human XPR1 protein binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family. The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2 NUC-2 contains several ankyrin repeats pfam00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine xenotropic and polytropic leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signalling and result in cell toxicity and death. The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organizms. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor.


Pssm-ID: 460807 [Multi-domain]  Cd Length: 339  Bit Score: 49.48  E-value: 4.44e-06
                          10        20
                  ....*....|....*....|....*....
gi 719998953    4 FGKKLKERQIQEWQGYYINYKLMKKKVKQ 32
Cdd:pfam03105   3 FGKELEENLVPEWRDAYLDYKQLKKLIKK 31
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 257-395 6.62e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 48.65  E-value: 6.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 257 TFLYMVNTYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKsyF---RPLVFSSIVLLVGNTLYALAy 333
Cdd:COG0477   23 TFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDR--YgrkRVLLIGLLLFGLASLLCGLA- 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 719998953 334 dfNSLAVLLIGRLFCGLGSA--RAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLL 395
Cdd:COG0477  100 --PSPELLIAARALQGIGAGglMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
Sugar_tr pfam00083
Sugar (and other) transporter;
260-428 8.05e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 48.81  E-value: 8.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  260 YMVNTYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRP-LVFSSIVLLVGNTLYALAYDFNSL 338
Cdd:pfam00083  23 LTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKsLLIANVLFVIGAVLQGAAKGKWSV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  339 AVLLIGRLFCGL--GSARAVNRRYISDCVPVKIRmqasAGFVSASALGMACGPALAgllQTRFKIYKITFNEDtlpGWvm 416
Cdd:pfam00083 103 YQLIVGRVLVGIgvGGASVLAPMYISEIAPKKLR----GALGSLYQLAITFGILLA---YIFGLGLNKTSNSD---GW-- 170

                         170
                  ....*....|..
gi 719998953  417 alAWLFYLLWLW 428
Cdd:pfam00083 171 --RIPLGLQLVP 180
SPX_BAH1-like cd14482
SPX domain of the E3 ubiquitin-protein ligase BAH1/NLA and similar proteins; This region has ...
 107-133 7.49e-05

SPX domain of the E3 ubiquitin-protein ligase BAH1/NLA and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. BAH1 (benzoic acid hypersensitive 1) appears to function as an E3 ubiquitin ligase; the protein contains an SPX and a RING finger domain. It has been suggested that BAH1/NLA is involved in the regulation of plant immune responses, probably via a pathway of salicylic acid biosynthesis that includes benzoic acid as an intermediate.


Pssm-ID: 269903  Cd Length: 156  Bit Score: 43.49  E-value: 7.49e-05
                         10        20
                 ....*....|....*....|....*..
gi 719998953 107 GQDLLKllfFVEMNAIGIRKILKKFDK 133
Cdd:cd14482  125 GRDLVN---YATMNAIAIRKILKKYDK 148
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 258-640 8.42e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.50  E-value: 8.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 258 FLYMVNTYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRPLVFSSIVLLVGntLYALAYDFNS 337
Cdd:cd06174    6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFAL--GALLFAFAPS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 338 LAVLLIGRLFCGLGSA--RAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRFKIYKitfnedTLPGWV 415
Cdd:cd06174   84 FWLLLLGRFLLGLGSGliDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGW------RAVFLI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 416 MALAWLFYLLWLWISFKEPSHEshennvaQQVSTEAVESKLENGLTKPLLlsseekerdedddqevdgseeapeesHRPA 495
Cdd:cd06174  158 AAALALLAAILLLLVVPDPPES-------ARAKNEEASSKSVLKLLKRVL--------------------------KNPG 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 496 TSIAsayhlltpsvkvqLLIYFMLKYAMEILLSESSVITTYYFGWTTSSVAIFLACLGLTVLPVNIVVGSYISNMFEDRQ 575
Cdd:cd06174  205 LWLL-------------LLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP 271

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 719998953 576 ILLASEVMVCIGILLSFHIISPYSVpqyVFSALVTFVAAEVLEGVNLSLLSRVMSSRlARGTYNG 640
Cdd:cd06174  272 LLLIGLLLMALGLALLLLAPSLLLL---LLLLLLLGFGLGGLLPLSFALIAELFPPE-IRGTAFG 332
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 250-428 1.11e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.11  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 250 LILNLANTFLYMVNTYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRP--LVFSSIVLLVGNT 327
Cdd:cd06174  206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKplLLIGLLLMALGLA 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 328 LYALAYDFNSLAVLLIGrLFCGLGSARAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRFKIYKITFn 407
Cdd:cd06174  286 LLLLAPSLLLLLLLLLL-LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF- 363

                        170       180
                 ....*....|....*....|.
gi 719998953 408 edtlpgWVMALAWLFYLLWLW 428
Cdd:cd06174  364 ------LVLAVLLLLAAILLL 378
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 258-370 1.12e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.87  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 258 FLYMVNTYIIVPTAD--NYSLSLGAAATVCGVVIGSMAVAQVFSSVyFSAWSNKSYFR--PLVFSSIVLLVGNTLYALAy 333
Cdd:cd17315    7 LLFGYDLGVINGALLyiAKDLGFGLSTSLQGLVVSSLLLGAAIGSL-FGGPLADRFGRrkSLLIAAVLYVIGALLSALA- 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 719998953 334 dfNSLAVLLIGRLFCGL--GSARAVNRRYISDCVPVKIR 370
Cdd:cd17315   85 --PNVWVLIVGRFLLGLgvGLASVLVPLYISEIAPAKIR 121
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 258-434 1.74e-04

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 44.51  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 258 FLYMVNTYIIVPTADNYSLSL-GAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRPLV-FSSIVLLVGNTLYALAydf 335
Cdd:cd17472    6 SLRMLGMFLVLPVLSVYAKSLpGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVIlFGLLLFIAGSLLAAYA--- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 336 NSLAVLLIGRLFCGLGSARAVNRRYISDCVPVKIRMQASAgFVSAS-----ALGMACGPalagLLQTRFKIYKItFnedt 410
Cdd:cd17472   83 TSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAMA-LIGASigiafAISMVLGP----LLAAHLGVSGL-F---- 152

                        170       180
                 ....*....|....*....|....
gi 719998953 411 lpgWVMALAWLFYLLWLWISFKEP 434
Cdd:cd17472  153 ---LITAILSLVSLLILLFFVPDP 173
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 279-395 2.62e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.69  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 279 GAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRPLVFSSIVLLVGntLYALAYDFNSLAVLLIGRLFCGLG--SARAV 356
Cdd:cd17324  230 GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA--LLLLTLLGPSPLLLLVGLVLWGLGffAAHSA 307

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 719998953 357 NRRYISDCVPvKIRMQASAGFVSASALGMACGPALAGLL 395
Cdd:cd17324  308 LQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLV 345
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 246-419 3.55e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.34  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 246 NFMSLILNLAntfLYMVNTYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNK-SYFRPLVFSSIVLLV 324
Cdd:cd17504  183 NITALLAGFG---MFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARvGPRRVLLIGLVISAV 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 325 GntLYALAYDFNSLAVLLIGRLFCGLGSARAVNRRYISDCVPVKIRMQASAGFVSASA--LGMACGPALAGLLQTRFKIY 402
Cdd:cd17504  260 G--LLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLrtIGSAIGPAIAGAILTTYTVS 337

                        170
                 ....*....|....*..
gi 719998953 403 KITFNEDTLPGWVMALA 419
Cdd:cd17504  338 ITSGGVPTEGAYVLAFL 354
SPX_XPR1_like cd14477
SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins; ...
 4-133 4.96e-04

SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. The N-terminus of the human XPR1 protein (xenotropic and polytropic retrovirus receptor 1) binds directly to the beta subunit of the G-protein heterotrimer leading to increased production of cAMP. These findings suggest that all members of this family are involved in G-protein associated signal transduction. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with xenotropic and polytropic murine leukaemia viruses (MLV). Infection by these retroviruses can inhibit XPR1-mediated cAMP signaling and result in cell toxicity and death. Similarity between Syg1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae, and many other diverse organisms.


Pssm-ID: 269898 [Multi-domain]  Cd Length: 161  Bit Score: 41.12  E-value: 4.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953   4 FGKKLKERQIQEWQGYYINYKLMKKKVKQYSQQ---MQVGAQD--RRHVLK---EFSRMLDTQIEKIVLFLLEQQ----- 70
Cdd:cd14477    2 FGEHLSAHITPEWRKQYINYEELKAMLYAAVEQapsPEVTDEDvvKRYFAKfeeEFFQECDKELAKVNTFFSEKLaeaqr 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953  71 ---GLLASRLAKLGEQRTALLEQPDISQISDL----RESYRAVGQdlLKLLF------------FVEMNAIGIRKILKKF 131
Cdd:cd14477   82 kfaTLKNELLSSLEAQGESGAASSLIRRVFALlrkeRVKPRKLRD--LKLAFsefylslillqnYQNLNFTGFRKILKKH 159


                 ..
gi 719998953 132 DK 133
Cdd:cd14477  160 DK 161
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
229-386 5.12e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.04  E-value: 5.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 229 QEELPTPIEEQIDDQRYNFMSLILNLANTFLYMVNTYIIVPTADNYSLSLGAAatvcGVVIGSMAVAQVFSSVYFSAWSN 308
Cdd:COG2814  193 RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA----GLLLALFGLGGVLGALLAGRLAD 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 309 K-SYFRPLVFSSIVLLVGNTLYALAydfNSLAVLLIGRLFCGLG--SARAVNRRYISDCVPVKIRMQASAGFVSASALGM 385
Cdd:COG2814  269 RfGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGfgLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345


                 .
gi 719998953 386 A 386
Cdd:COG2814  346 P 346
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
244-431 5.65e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.93  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 244 RYNFMSLILNLANTFLYMVNTYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFRPLVFSSIVLL 323
Cdd:COG2271    6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 324 -VGNTLYALAydfNSLAVLLIGRLFCGLGSARA--VNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRFk 400
Cdd:COG2271   86 gLATLLFGFA---TSFWQLLLLRFLLGLGEAGFfpAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF- 161

                        170       180       190
                 ....*....|....*....|....*....|...
gi 719998953 401 iykitfnedtlpGWVMALAW--LFYLLWLWISF 431
Cdd:COG2271  162 ------------GWRAAFLIlgLPGLLLALLRF 182
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
254-434 9.13e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.16  E-value: 9.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 254 LANTFLYMVNTYIIVPTADNYSLSLGAAATVCGVVIGSMAVAQVFSSvYFSAWSNKSYFRPLVFSSIVLLVGNTLYALAY 333
Cdd:COG2271  191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGG-WLSDRLGRRRKLVLAIGLLLAALALLLLALLP 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 334 DFNSLAVLLIGrLFCGLGSARAVNRRYISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRFKiYKITFnedtlpg 413
Cdd:COG2271  270 SPALAIALLFL-AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAF------- 340

                        170       180
                 ....*....|....*....|.
gi 719998953 414 WVMALAWLFYLLWLWISFKEP 434
Cdd:COG2271  341 LLLAALALLAALLALLLLRET 361
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
272-440 1.00e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.18  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 272 DNYSLSLGAAATVcgvvIGSMAVAQVFSSVYFSAWSNK-SYFRPLVFSSIVLLVGNTLYALAYDFNSLAVLLIGRLFCGL 350
Cdd:COG2223  234 DQFGLSAATAGLL----AALFALLGALGRPLGGWLSDRiGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLAL 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 351 GSARAVNRRYISDCVPVKiRMQASAGFVSAS-ALGMACGPALAGLLQTRFKIYKITFnedtlpgWVMALAWLFYLLWLWI 429
Cdd:COG2223  310 GGGNGAVFALVPDIFPTK-NAGAVYGLVGAAgGLGGFLGPLLFGALLDATGSYTAAF-------LVFAVLALVALVLTLL 381

                        170
                 ....*....|.
gi 719998953 430 SFKEPSHESHE 440
Cdd:COG2223  382 LYRRPRRAAAA 392
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 278-446 3.40e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 3.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 278 LGAAATVCGVVIGSMAVAQVFSSVYFSAWSNKSYFR--PLVFSSIVLLVGNTLYALAYDFnsLAVLLIGRLFCGLGSAR- 354
Cdd:cd17471   27 LGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRkpLILLALLAGALGYLLFAFLRNY--WVLLLVGVVLLSLGAAAf 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 355 ----AVNRRYISDCVPVKIRMqASAGFVSASALGMACGPALAGLLQTRFKiYKITFnedtlpgWVMALAWLFYLLWLWIS 430
Cdd:cd17471  105 pqlfALAREYADRSSGRDATL-FNSVLRAAFSLAWVIGPPLAFLLLDVLG-FTGLF-------LLAALLYLVVALLVLFL 175

                        170
                 ....*....|....*.
gi 719998953 431 FKEPSHESHENNVAQQ 446
Cdd:cd17471  176 LPSVKPPAQKATPASS 191
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 254-427 5.97e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 5.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 254 LANTFLYMVNTYIivptADNYSLSLGAAATVCGVVIGSMAVAQVFSSVYFSawsnksYFRPLVFSSIVLLVGNTLYALAY 333
Cdd:cd17473  208 LAMLLFYVIPIQL----PFLLQERGGGSAALIGLALAIASLAGAIGALLFG------RLKRRLGKRRLLAIGFALMALGF 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 719998953 334 DF----NSLAVLLIGRLFCGLGSA---RAVNRRyISDCVPVKIRMQASAGFVSASALGMACGPALAGLLQTRFKIYKITF 406
Cdd:cd17473  278 LLlalaSGLWVVLLGAILAGLGFGlllPTLNSW-AMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAF 356

                        170       180
                 ....*....|....*....|.
gi 719998953 407 nedTLPGWVMALAWLFYLLWL 427
Cdd:cd17473  357 ---LILGVLALVLAIVLLLLR 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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