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Conserved domains on  [gi|688573476|ref|XP_009303445|]
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inactive glycosyltransferase 25 family member 3 [Danio rerio]

Protein Classification

Glyco_tranf_GTA_type and Glyco_transf_25 domain-containing protein( domain architecture ID 10953614)

Glyco_tranf_GTA_type and Glyco_transf_25 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG3306 COG3306
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
324-536 7.17e-37

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 137.44  E-value: 7.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476 324 IYLINLRRRQDRRDRMLWSLYELEIDAKVVDAIDGAALNSSDIKilgvDLLPGYYDPFSGRTLTKGEVGCFLSHYYIWKE 403
Cdd:COG3306    3 IFVINLDRSTERREHIEAQLARLGLDFEFFDAVDGRDLSEEELA----RYDRAKALRRYGRPLTPGEIGCFLSHRKAWQK 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476 404 MVDMQLDKALIFEDDVRFQANFKrrmmRLMEEVEQVELDWDIIYLG---RKKVNPGEEVPVENVRNLVFADYSYW-TLSY 479
Cdd:COG3306   79 IVESGLPYALILEDDVILSPDFA----EVLEALAWLPADWDIVKLEtskRKVFLGRRKIKKLGGYRLVRPYSPPLgTAGY 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 688573476 480 AISLQGAQKLLN-AEPVSkmLPVDEFLpimydkhpnedykSHFPNRNLMAYSTHPLLV 536
Cdd:COG3306  155 LISRKAAKKLLAlLEPID--RPVDDFL-------------FRFWLHGLRVYQVRPALV 197
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
35-164 1.71e-06

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd04192:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 229  Bit Score: 49.21  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476  35 VVIAiiARNAAHSLPHYLGALERLNYPKERISVWAATDHNIDNTTAMLrEWLTvMQTQYHYVEWRPSDKPTSYagelgpk 114
Cdd:cd04192    1 VVIA--ARNEAENLPRLLQSLSALDYPKEKFEVILVDDHSTDGTVQIL-EFAA-AKPNFQLKILNNSRVSISG------- 69
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 688573476 115 hwtnsryeyimklKQAALNFA-KKRWADYILYSDTDnILTNPDTLHLLMAE 164
Cdd:cd04192   70 -------------KKNALTTAiKAAKGDWIVTTDAD-CVVPSNWLLTFVAF 106
 
Name Accession Description Interval E-value
COG3306 COG3306
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
324-536 7.17e-37

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 137.44  E-value: 7.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476 324 IYLINLRRRQDRRDRMLWSLYELEIDAKVVDAIDGAALNSSDIKilgvDLLPGYYDPFSGRTLTKGEVGCFLSHYYIWKE 403
Cdd:COG3306    3 IFVINLDRSTERREHIEAQLARLGLDFEFFDAVDGRDLSEEELA----RYDRAKALRRYGRPLTPGEIGCFLSHRKAWQK 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476 404 MVDMQLDKALIFEDDVRFQANFKrrmmRLMEEVEQVELDWDIIYLG---RKKVNPGEEVPVENVRNLVFADYSYW-TLSY 479
Cdd:COG3306   79 IVESGLPYALILEDDVILSPDFA----EVLEALAWLPADWDIVKLEtskRKVFLGRRKIKKLGGYRLVRPYSPPLgTAGY 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 688573476 480 AISLQGAQKLLN-AEPVSkmLPVDEFLpimydkhpnedykSHFPNRNLMAYSTHPLLV 536
Cdd:COG3306  155 LISRKAAKKLLAlLEPID--RPVDDFL-------------FRFWLHGLRVYQVRPALV 197
Glyco_transf_25 pfam01755
Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to ...
321-505 4.96e-31

Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyze the transfer of various sugars onto the growing LPS chain during its biosynthesis.


Pssm-ID: 366794  Cd Length: 200  Bit Score: 119.85  E-value: 4.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476  321 FDEIYLINLRRRQDRRDRMLWSLYELEIDAKVVDAIDGAALNSSDIKIlgvDLLPGYYDPFSGRTLTKGEVGCFLSHYYI 400
Cdd:pfam01755   1 MIKIYVISLKRATERREHIQKEFGKLNIPFQFFDAIDGKELPNHLLFK---LYNFLLRSKYAGRPLTLGEIGCFLSHYSL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476  401 WKEMVDMQLDKALIFEDDVRFQANFKRRMMRLMEEVEQVEldwdIIYLGRKKVNPGEEVPVENVRNLVFADYSY------ 474
Cdd:pfam01755  78 WQKCVELNLEYIIILEDDVILSENFKAILQFLLKEINELE----FLRLGEWLKTRFDPNDKFIVRLETFLMDSKkfkrtp 153
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 688573476  475 -----------------WTLSYAISLQGAQKLLNAEPVSKMlPVDEFL 505
Cdd:pfam01755 154 iadygnrafyllksghaGTAGYLITPKAAKKLLKYSKNWPL-PVDDLM 200
Glyco_transf_25 cd06532
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of ...
323-505 2.07e-29

Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of Neisseria gonorrhoeae and Lic2A of Haemophilus influenzae. M. catarrhalis Lgt2 catalyzes the addition of galactose (Gal) to the growing chain of LOS on the cell surface. N. gonorrhoeae LgtB and LgtE link Gal-beta(1,4) to GlcNAc (N-acetylglucosamine) and Glc (glucose), respectively. The genes encoding LgtB and LgtE are two genes of a five gene locus involved in the synthesis of gonococcal LOS. LgtE is believed to perform the first step in LOS biosynthesis.


Pssm-ID: 133474  Cd Length: 128  Bit Score: 112.70  E-value: 2.07e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476 323 EIYLINLRRRQDRRDRMLWSLYELEIDAKVVDAIDGAALNSSDIKilgvDLLPGYYDPFSGRTLTKGEVGCFLSHYYIWK 402
Cdd:cd06532    1 KIFVINLDRSTDRRERMEAQLAALGLDFEFFDAVDGKDLSEEELA----ALYDALFLPRYGRPLTPGEIGCFLSHYKLWQ 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476 403 EMVDMQLDKALIFEDDVRFQANfkrrmmrlmeeveqveldwdiiylgrkkvnpgeevpvenvrnlvfadysyWTLSYAIS 482
Cdd:cd06532   77 KIVESNLEYALILEDDAILDPD--------------------------------------------------GTAGYLVS 106
                        170       180
                 ....*....|....*....|...
gi 688573476 483 LQGAQKLLNAEPvSKMLPVDEFL 505
Cdd:cd06532  107 RKGAKKLLAALE-PIDLPVDVFL 128
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
35-164 1.71e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 49.21  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476  35 VVIAiiARNAAHSLPHYLGALERLNYPKERISVWAATDHNIDNTTAMLrEWLTvMQTQYHYVEWRPSDKPTSYagelgpk 114
Cdd:cd04192    1 VVIA--ARNEAENLPRLLQSLSALDYPKEKFEVILVDDHSTDGTVQIL-EFAA-AKPNFQLKILNNSRVSISG------- 69
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 688573476 115 hwtnsryeyimklKQAALNFA-KKRWADYILYSDTDnILTNPDTLHLLMAE 164
Cdd:cd04192   70 -------------KKNALTTAiKAAKGDWIVTTDAD-CVVPSNWLLTFVAF 106
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
1-163 3.46e-06

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 48.97  E-value: 3.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476   1 MLSWIITIWTFLAVVQCYFSEEnyteeSKMQPPTVVIAIIARNAAHSLPHYLGALERLNYPKERISVWAATDHNIDNTTA 80
Cdd:COG1215    2 LLLLALLALLYLLLLALARRRR-----APADLPRVSVIIPAYNEEAVIEETLRSLLAQDYPKEKLEVIVVDDGSTDETAE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476  81 MLREWltvmQTQYHYVEWRPSDKPTSYAGELgpkhwtnsryeyimklkQAALNFAKkrwADYILYSDTDNILTnPDTLHL 160
Cdd:COG1215   77 IAREL----AAEYPRVRVIERPENGGKAAAL-----------------NAGLKAAR---GDIVVFLDADTVLD-PDWLRR 131

                 ...
gi 688573476 161 LMA 163
Cdd:COG1215  132 LVA 134
 
Name Accession Description Interval E-value
COG3306 COG3306
Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope ...
324-536 7.17e-37

Glycosyltransferase involved in LPS biosynthesis, GR25 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442535 [Multi-domain]  Cd Length: 238  Bit Score: 137.44  E-value: 7.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476 324 IYLINLRRRQDRRDRMLWSLYELEIDAKVVDAIDGAALNSSDIKilgvDLLPGYYDPFSGRTLTKGEVGCFLSHYYIWKE 403
Cdd:COG3306    3 IFVINLDRSTERREHIEAQLARLGLDFEFFDAVDGRDLSEEELA----RYDRAKALRRYGRPLTPGEIGCFLSHRKAWQK 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476 404 MVDMQLDKALIFEDDVRFQANFKrrmmRLMEEVEQVELDWDIIYLG---RKKVNPGEEVPVENVRNLVFADYSYW-TLSY 479
Cdd:COG3306   79 IVESGLPYALILEDDVILSPDFA----EVLEALAWLPADWDIVKLEtskRKVFLGRRKIKKLGGYRLVRPYSPPLgTAGY 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 688573476 480 AISLQGAQKLLN-AEPVSkmLPVDEFLpimydkhpnedykSHFPNRNLMAYSTHPLLV 536
Cdd:COG3306  155 LISRKAAKKLLAlLEPID--RPVDDFL-------------FRFWLHGLRVYQVRPALV 197
Glyco_transf_25 pfam01755
Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to ...
321-505 4.96e-31

Glycosyltransferase family 25 (LPS biosynthesis protein); Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyze the transfer of various sugars onto the growing LPS chain during its biosynthesis.


Pssm-ID: 366794  Cd Length: 200  Bit Score: 119.85  E-value: 4.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476  321 FDEIYLINLRRRQDRRDRMLWSLYELEIDAKVVDAIDGAALNSSDIKIlgvDLLPGYYDPFSGRTLTKGEVGCFLSHYYI 400
Cdd:pfam01755   1 MIKIYVISLKRATERREHIQKEFGKLNIPFQFFDAIDGKELPNHLLFK---LYNFLLRSKYAGRPLTLGEIGCFLSHYSL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476  401 WKEMVDMQLDKALIFEDDVRFQANFKRRMMRLMEEVEQVEldwdIIYLGRKKVNPGEEVPVENVRNLVFADYSY------ 474
Cdd:pfam01755  78 WQKCVELNLEYIIILEDDVILSENFKAILQFLLKEINELE----FLRLGEWLKTRFDPNDKFIVRLETFLMDSKkfkrtp 153
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 688573476  475 -----------------WTLSYAISLQGAQKLLNAEPVSKMlPVDEFL 505
Cdd:pfam01755 154 iadygnrafyllksghaGTAGYLITPKAAKKLLKYSKNWPL-PVDDLM 200
Glyco_transf_25 cd06532
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of ...
323-505 2.07e-29

Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of Neisseria gonorrhoeae and Lic2A of Haemophilus influenzae. M. catarrhalis Lgt2 catalyzes the addition of galactose (Gal) to the growing chain of LOS on the cell surface. N. gonorrhoeae LgtB and LgtE link Gal-beta(1,4) to GlcNAc (N-acetylglucosamine) and Glc (glucose), respectively. The genes encoding LgtB and LgtE are two genes of a five gene locus involved in the synthesis of gonococcal LOS. LgtE is believed to perform the first step in LOS biosynthesis.


Pssm-ID: 133474  Cd Length: 128  Bit Score: 112.70  E-value: 2.07e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476 323 EIYLINLRRRQDRRDRMLWSLYELEIDAKVVDAIDGAALNSSDIKilgvDLLPGYYDPFSGRTLTKGEVGCFLSHYYIWK 402
Cdd:cd06532    1 KIFVINLDRSTDRRERMEAQLAALGLDFEFFDAVDGKDLSEEELA----ALYDALFLPRYGRPLTPGEIGCFLSHYKLWQ 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476 403 EMVDMQLDKALIFEDDVRFQANfkrrmmrlmeeveqveldwdiiylgrkkvnpgeevpvenvrnlvfadysyWTLSYAIS 482
Cdd:cd06532   77 KIVESNLEYALILEDDAILDPD--------------------------------------------------GTAGYLVS 106
                        170       180
                 ....*....|....*....|...
gi 688573476 483 LQGAQKLLNAEPvSKMLPVDEFL 505
Cdd:cd06532  107 RKGAKKLLAALE-PIDLPVDVFL 128
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
35-164 1.71e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 49.21  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476  35 VVIAiiARNAAHSLPHYLGALERLNYPKERISVWAATDHNIDNTTAMLrEWLTvMQTQYHYVEWRPSDKPTSYagelgpk 114
Cdd:cd04192    1 VVIA--ARNEAENLPRLLQSLSALDYPKEKFEVILVDDHSTDGTVQIL-EFAA-AKPNFQLKILNNSRVSISG------- 69
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 688573476 115 hwtnsryeyimklKQAALNFA-KKRWADYILYSDTDnILTNPDTLHLLMAE 164
Cdd:cd04192   70 -------------KKNALTTAiKAAKGDWIVTTDAD-CVVPSNWLLTFVAF 106
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
1-163 3.46e-06

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 48.97  E-value: 3.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476   1 MLSWIITIWTFLAVVQCYFSEEnyteeSKMQPPTVVIAIIARNAAHSLPHYLGALERLNYPKERISVWAATDHNIDNTTA 80
Cdd:COG1215    2 LLLLALLALLYLLLLALARRRR-----APADLPRVSVIIPAYNEEAVIEETLRSLLAQDYPKEKLEVIVVDDGSTDETAE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688573476  81 MLREWltvmQTQYHYVEWRPSDKPTSYAGELgpkhwtnsryeyimklkQAALNFAKkrwADYILYSDTDNILTnPDTLHL 160
Cdd:COG1215   77 IAREL----AAEYPRVRVIERPENGGKAAAL-----------------NAGLKAAR---GDIVVFLDADTVLD-PDWLRR 131

                 ...
gi 688573476 161 LMA 163
Cdd:COG1215  132 LVA 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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