transcription factor Dp-1a isoform X1 [Danio rerio]
DP family transcription factor( domain architecture ID 11130207)
DP family transcription factor can stimulate E2F-dependent transcription; it binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3'
List of domain hits
Name | Accession | Description | Interval | E-value | |||
DP | pfam08781 | Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell ... |
200-338 | 2.08e-90 | |||
Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer and negatively regulates the G1-S transition. : Pssm-ID: 462601 Cd Length: 138 Bit Score: 269.08 E-value: 2.08e-90
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E2F_TDP | pfam02319 | E2F/DP family winged-helix DNA-binding domain; This family contains the transcription factor ... |
115-193 | 8.94e-21 | |||
E2F/DP family winged-helix DNA-binding domain; This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins. : Pssm-ID: 460530 Cd Length: 65 Bit Score: 85.18 E-value: 8.94e-21
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Name | Accession | Description | Interval | E-value | |||
DP | pfam08781 | Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell ... |
200-338 | 2.08e-90 | |||
Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer and negatively regulates the G1-S transition. Pssm-ID: 462601 Cd Length: 138 Bit Score: 269.08 E-value: 2.08e-90
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DP_DD | cd14458 | Dimerization domain of DP; DP functions as a binding partner for E2F transcription factors. DP ... |
198-303 | 1.71e-59 | |||
Dimerization domain of DP; DP functions as a binding partner for E2F transcription factors. DP and E2F form heterodimers and play important roles in regulating genes involved in DNA synthesis, cell cycle progression, proliferation and apoptosis. The transcriptional activity of E2F is inhibited by the retinoblastoma protein (Rb) which binds to the E2F-DP heterodimer, blocks the transactivation domain, and negatively regulates the G1-S transition. DP is distantly related to E2F. In humans, there are at least six closely related E2F and two DP family members, all containing a DNA binding domain, a coiled-coil (CC) region, and a marked-box domain. E2F1 to E2F5 also contain a C-terminal transactivation domain. Pssm-ID: 271217 Cd Length: 105 Bit Score: 188.55 E-value: 1.71e-59
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E2F_TDP | pfam02319 | E2F/DP family winged-helix DNA-binding domain; This family contains the transcription factor ... |
115-193 | 8.94e-21 | |||
E2F/DP family winged-helix DNA-binding domain; This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins. Pssm-ID: 460530 Cd Length: 65 Bit Score: 85.18 E-value: 8.94e-21
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Name | Accession | Description | Interval | E-value | |||
DP | pfam08781 | Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell ... |
200-338 | 2.08e-90 | |||
Transcription factor DP; DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer and negatively regulates the G1-S transition. Pssm-ID: 462601 Cd Length: 138 Bit Score: 269.08 E-value: 2.08e-90
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DP_DD | cd14458 | Dimerization domain of DP; DP functions as a binding partner for E2F transcription factors. DP ... |
198-303 | 1.71e-59 | |||
Dimerization domain of DP; DP functions as a binding partner for E2F transcription factors. DP and E2F form heterodimers and play important roles in regulating genes involved in DNA synthesis, cell cycle progression, proliferation and apoptosis. The transcriptional activity of E2F is inhibited by the retinoblastoma protein (Rb) which binds to the E2F-DP heterodimer, blocks the transactivation domain, and negatively regulates the G1-S transition. DP is distantly related to E2F. In humans, there are at least six closely related E2F and two DP family members, all containing a DNA binding domain, a coiled-coil (CC) region, and a marked-box domain. E2F1 to E2F5 also contain a C-terminal transactivation domain. Pssm-ID: 271217 Cd Length: 105 Bit Score: 188.55 E-value: 1.71e-59
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E2F_TDP | pfam02319 | E2F/DP family winged-helix DNA-binding domain; This family contains the transcription factor ... |
115-193 | 8.94e-21 | |||
E2F/DP family winged-helix DNA-binding domain; This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins. Pssm-ID: 460530 Cd Length: 65 Bit Score: 85.18 E-value: 8.94e-21
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Blast search parameters | ||||
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