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Conserved domains on  [gi|672079485|ref|XP_008769276|]
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stabilin-1 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Link_Domain super family cl02612
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 2266-2358 6.44e-46

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


The actual alignment was detected with superfamily member cd03515:

Pssm-ID: 470631  Cd Length: 93  Bit Score: 160.71  E-value: 6.44e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2266 GVFHIQATSGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISLGV 2345
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 672079485 2346 RKNLSERWDAYCY 2358
Cdd:cd03515    81 RLNLSERWDAYCY 93
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 502-647 1.56e-27

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


:

Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 110.77  E-value: 1.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  502 PPPLPGDPKKTVGQILASTEAFTRFETILENCGLPAMLDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAG-LSKLQELVRY 580
Cdd:COG2335    22 AEGAAMAPTKNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPEnKATLTKILTY 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672079485  581 HIYNhGQLTVEKLISKGRFLTMANQVLTVNISeEGRILLGpeGVPVRRVDVPAANGVIHMLEGILLP 647
Cdd:COG2335   102 HVVP-GKVTAADLKDGKTLTTLQGQTLTVTVS-GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1666-1770 2.34e-25

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 103.10  E-value: 2.34e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1666 KELKG-DGPFTIFVPHSDLISNMSQGELARMRAHRQL---VFRYHVLGCRkLGSQELLDQGYVTALSGHTLRISEREGSI 1741
Cdd:pfam02469   17 DTLNGsQGPFTVFAPTNEAFAKLPAGTLNFLLKDKEQlknLLKYHVVPGR-LTSSDLKNGGTLATLQGSKLRVNVTGGSV 95

                           90       100
                   ....*....|....*....|....*....
gi 672079485  1742 YLNDfARVVSSDHEAVNGVLHFIDRVLLP 1770
Cdd:pfam02469   96 TVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1796-1926 7.36e-25

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 101.56  E-value: 7.36e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1796 QYKIFSRLLTVAGLLPMLQDaSHRPFTMLWPTDSALEALSPDRKNWLYheDHRDKLAAILRGHVIRNiEASASDLPNLGQ 1875
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNG-SQGPFTVFAPTNEAFAKLPAGTLNFLL--KDKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 672079485  1876 LRTMHGNTISFSCglaRPGELMVgeNEARIVQRYLLFEGGLAYGIDQLLEP 1926
Cdd:pfam02469   78 LATLQGSKLRVNV---TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1100-1180 1.84e-12

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 66.51  E-value: 1.84e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1100 NLVQSPPPPTLLLRAHFLQGAFSEEELArlSGQQVATLSATThWQIHNTSGRVQVQNATVDVPDLLATNGVLHIISQVLL 1179
Cdd:pfam02469   46 FLLKDKEQLKNLLKYHVVPGRLTSSDLK--NGGTLATLQGSK-LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLL 122


                   .
gi 672079485  1180 P 1180
Cdd:pfam02469  123 P 123
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
2425-2520 2.29e-08

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


:

Pssm-ID: 214719  Cd Length: 97  Bit Score: 53.91  E-value: 2.29e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   2425 TLFVPVNEGF------LDNMT--LSGPDLELHASNATFLSANASQGTLLPAHSGLSLFISDTGPDNIslvplapgaVVVS 2496
Cdd:smart00554    1 TVFAPTDEAFqklppdLNSLLadKLKNLLLYHVVPGRLSSADLLNGGTLPTLAGSKLRITRSGGSGT---------VTVN 71

                            90       100
                    ....*....|....*....|....*.
gi 672079485   2497 HVMV--WDIMAFNGVIHALASPLLTP 2520
Cdd:smart00554   72 GARIveADIAATNGVVHVIDRVLLPP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1519-1555 1.68e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.52  E-value: 1.68e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 672079485  1519 CTSGHGGCSPYANCTKVaPGQRTCTCLDGYTGDGELC 1555
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2153-2188 7.02e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 7.02e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672079485  2153 CQKGHGGCSKHANCSQVGTVVTCTCLPAYEGDGWSC 2188
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Fasciclin super family cl02663
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 391-494 5.98e-06

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


The actual alignment was detected with superfamily member pfam02469:

Pssm-ID: 470649  Cd Length: 123  Bit Score: 47.63  E-value: 5.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   391 QEILTTSGPFTVLVPSMFSVSAISSSN-----MNATLAQQLCRQHIIPGEHILENIgpSNTRRWWTLAGQEITVTFKNlr 465
Cdd:pfam02469   17 DTLNGSQGPFTVFAPTNEAFAKLPAGTlnfllKDKEQLKNLLKYHVVPGRLTSSDL--KNGGTLATLQGSKLRVNVTG-- 92

                           90       100       110
                   ....*....|....*....|....*....|....
gi 672079485   466 ysykyedqpQQFSIQKA-----NYIAANGVFHTV 494
Cdd:pfam02469   93 ---------GSVTVNGArvvqaDIEATNGVIHVI 117
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 955-991 8.31e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.51  E-value: 8.31e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 672079485   955 CRVGNGGCHGLATCKAVGGgQRVCTCPPHFGGDGFSC 991
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1561-1595 9.34e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.51  E-value: 9.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 672079485  1561 CLVHNGGCHVNAECIPTGPqQVSCNCREGYSGDGI 1595
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGV 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2194-2231 2.15e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 2.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 672079485  2194 CLDGHrGGCSEHADCFNTgPNTRRCECHTGYVGDGLQC 2231
Cdd:pfam12947    1 CSDNN-GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1604-1641 6.33e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 6.33e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 672079485  1604 CSQNNGGCSPYAVCKSTgDGQRTCSCDSTHTvGDGITC 1641
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYT-GDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 918-949 1.81e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 1.81e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672079485   918 GGCHADALCSYVgPGQSRCTCKLGFAGDGYEC 949
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 834-863 7.68e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 7.68e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 672079485   834 PCHPDAHCVIQEGVARCVCHDGFEGNGFSC 863
Cdd:pfam12947    7 GCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Fasciclin super family cl02663
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1224-1313 3.04e-03

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


The actual alignment was detected with superfamily member smart00554:

Pssm-ID: 470649  Cd Length: 97  Bit Score: 39.27  E-value: 3.04e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   1224 TIFVPTNHSLE--TQGNKSILG---IDIVRHHVILGeALSVEVLRKGGHRNSLLGPAHWLVFYNHSGQPEVNHVPLEGPL 1298
Cdd:smart00554    1 TVFAPTDEAFQklPPDLNSLLAdklKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARIVEAD 79

                            90
                    ....*....|....*
gi 672079485   1299 LEAPGSALFGLSGIL 1313
Cdd:smart00554   80 IAATNGVVHVIDRVL 94
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2036-2081 3.11e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.72  E-value: 3.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 672079485 2036 PCSGHGVCLDG-ISGSGQCNCHPGFAGTACELCAPGAFGPQCQACRC 2081
Cdd:cd00055     3 DCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 2266-2358 6.44e-46

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 160.71  E-value: 6.44e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2266 GVFHIQATSGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISLGV 2345
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 672079485 2346 RKNLSERWDAYCY 2358
Cdd:cd03515    81 RLNLSERWDAYCY 93
LINK smart00445
Link (Hyaluronan-binding);
2264-2359 3.82e-35

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 130.15  E-value: 3.82e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   2264 QAGVFHIQATsGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISL 2343
Cdd:smart00445    1 DGGVFHVEKN-GRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQY 79

                            90
                    ....*....|....*.
gi 672079485   2344 GVRKNLSeRWDAYCYR 2359
Cdd:smart00445   80 GFPDPTS-RYDAYCFN 94
Xlink pfam00193
Extracellular link domain;
2266-2358 3.29e-34

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 127.30  E-value: 3.29e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  2266 GVFHIQAtSGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISLGV 2345
Cdd:pfam00193    1 GVFHLES-PGRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 672079485  2346 RKNLSERWDAYCY 2358
Cdd:pfam00193   80 RDPLSERYDAYCY 92
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 502-647 1.56e-27

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 110.77  E-value: 1.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  502 PPPLPGDPKKTVGQILASTEAFTRFETILENCGLPAMLDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAG-LSKLQELVRY 580
Cdd:COG2335    22 AEGAAMAPTKNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPEnKATLTKILTY 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672079485  581 HIYNhGQLTVEKLISKGRFLTMANQVLTVNISeEGRILLGpeGVPVRRVDVPAANGVIHMLEGILLP 647
Cdd:COG2335   102 HVVP-GKVTAADLKDGKTLTTLQGQTLTVTVS-GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1666-1770 2.34e-25

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 103.10  E-value: 2.34e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1666 KELKG-DGPFTIFVPHSDLISNMSQGELARMRAHRQL---VFRYHVLGCRkLGSQELLDQGYVTALSGHTLRISEREGSI 1741
Cdd:pfam02469   17 DTLNGsQGPFTVFAPTNEAFAKLPAGTLNFLLKDKEQlknLLKYHVVPGR-LTSSDLKNGGTLATLQGSKLRVNVTGGSV 95

                           90       100
                   ....*....|....*....|....*....
gi 672079485  1742 YLNDfARVVSSDHEAVNGVLHFIDRVLLP 1770
Cdd:pfam02469   96 TVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1796-1926 7.36e-25

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 101.56  E-value: 7.36e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1796 QYKIFSRLLTVAGLLPMLQDaSHRPFTMLWPTDSALEALSPDRKNWLYheDHRDKLAAILRGHVIRNiEASASDLPNLGQ 1875
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNG-SQGPFTVFAPTNEAFAKLPAGTLNFLL--KDKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 672079485  1876 LRTMHGNTISFSCglaRPGELMVgeNEARIVQRYLLFEGGLAYGIDQLLEP 1926
Cdd:pfam02469   78 LATLQGSKLRVNV---TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 523-647 3.35e-21

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 91.16  E-value: 3.35e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   523 FTRFETILENCGLPAMLDGP-GPFTVFAPSNEAVDSLRDGRLIYLFtAGLSKLQELVRYHIYNhGQLTVEKLISKGRFLT 601
Cdd:pfam02469    3 FSTFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLL-KDKEQLKNLLKYHVVP-GRLTSSDLKNGGTLAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 672079485   602 MANQVLTVNIsEEGRILLgpEGVPVRRVDVPAANGVIHMLEGILLP 647
Cdd:pfam02469   81 LQGSKLRVNV-TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
546-648 8.29e-20

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 86.26  E-value: 8.29e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485    546 TVFAPSNEAVDSLRDGRliYLFTAglSKLQELVRYHIYNhGQLTVEKLISKGRFLTMANQVLTVNISEeGRILLGPEGVP 625
Cdd:smart00554    1 TVFAPTDEAFQKLPPDL--NSLLA--DKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSG-GSGTVTVNGAR 74

                            90       100
                    ....*....|....*....|...
gi 672079485    626 VRRVDVPAANGVIHMLEGILLPP 648
Cdd:smart00554   75 IVEADIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1675-1771 1.25e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 83.18  E-value: 1.25e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   1675 TIFVPHSDLISNMSQGELARMRAHRQLVFRYHVLGcRKLGSQELLDQGYVTALSGHTLRISERE--GSIYLNDfARVVSS 1752
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVEA 78

                            90
                    ....*....|....*....
gi 672079485   1753 DHEAVNGVLHFIDRVLLPP 1771
Cdd:smart00554   79 DIAATNGVVHVIDRVLLPP 97
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1668-1770 1.50e-18

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 84.96  E-value: 1.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 1668 LKGDGPFTIFVPHSDLISNMSQGELARM-----RAHRQLVFRYHVLGcRKLGSQELLDQGYVTALSGHTLRISEREGSIY 1742
Cdd:COG2335    59 LSGEGPFTVFAPTDAAFAALPAGTLDALlkpenKATLTKILTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGGGVT 137

                          90       100
                  ....*....|....*....|....*...
gi 672079485 1743 LNDfARVVSSDHEAVNGVLHFIDRVLLP 1770
Cdd:COG2335   138 VNG-ANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1822-1927 2.16e-17

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 79.33  E-value: 2.16e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   1822 TMLWPTDSALEALSPDRKNWLyhedhRDKLAAILRGHVIRNiEASASDLPNLGQLRTMHGNTISFSCglaRPGELMVGEN 1901
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITR---SGGSGTVTVN 71

                            90       100
                    ....*....|....*....|....*.
gi 672079485   1902 EARIVQRYLLFEGGLAYGIDQLLEPP 1927
Cdd:smart00554   72 GARIVEADIAATNGVVHVIDRVLLPP 97
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1788-1926 4.51e-15

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 74.94  E-value: 4.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 1788 VTAAAESFQYKIFSRLLTVAGLLPMLQDAshRPFTMLWPTDSALEALSPD-RKNWLYHEDhRDKLAAILRGHVIRNiEAS 1866
Cdd:COG2335    34 VETAANNPDFSTLVAALKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGtLDALLKPEN-KATLTKILTYHVVPG-KVT 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 1867 ASDLPNLGQLRTMHGNTISFScglARPGELMVgeNEARIVQRYLLFEGGLAYGIDQLLEP 1926
Cdd:COG2335   110 AADLKDGKTLTTLQGQTLTVT---VSGGGVTV--NGANVITADIEASNGVIHVIDKVLLP 164
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1100-1180 1.84e-12

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 66.51  E-value: 1.84e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1100 NLVQSPPPPTLLLRAHFLQGAFSEEELArlSGQQVATLSATThWQIHNTSGRVQVQNATVDVPDLLATNGVLHIISQVLL 1179
Cdd:pfam02469   46 FLLKDKEQLKNLLKYHVVPGRLTSSDLK--NGGTLATLQGSK-LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLL 122


                   .
gi 672079485  1180 P 1180
Cdd:pfam02469  123 P 123
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1100-1180 2.82e-11

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 64.16  E-value: 2.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 1100 NLVQSPPPPTL--LLRAHFLQGAFSEEELArlSGQQVATLSATThWQIHNTSGRVQVQNATVDVPDLLATNGVLHIISQV 1177
Cdd:COG2335    85 ALLKPENKATLtkILTYHVVPGKVTAADLK--DGKTLTTLQGQT-LTVTVSGGGVTVNGANVITADIEASNGVIHVIDKV 161


                  ...
gi 672079485 1178 LLP 1180
Cdd:COG2335   162 LLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1111-1181 5.24e-11

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 61.22  E-value: 5.24e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672079485   1111 LLRAHFLQGAFSEEELarLSGQQVATLsATTHWQIH--NTSGRVQVQNATVDVPDLLATNGVLHIISQVLLPP 1181
Cdd:smart00554   28 LLLYHVVPGRLSSADL--LNGGTLPTL-AGSKLRITrsGGSGTVTVNGARIVEADIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
2425-2520 2.29e-08

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 53.91  E-value: 2.29e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   2425 TLFVPVNEGF------LDNMT--LSGPDLELHASNATFLSANASQGTLLPAHSGLSLFISDTGPDNIslvplapgaVVVS 2496
Cdd:smart00554    1 TVFAPTDEAFqklppdLNSLLadKLKNLLLYHVVPGRLSSADLLNGGTLPTLAGSKLRITRSGGSGT---------VTVN 71

                            90       100
                    ....*....|....*....|....*.
gi 672079485   2497 HVMV--WDIMAFNGVIHALASPLLTP 2520
Cdd:smart00554   72 GARIveADIAATNGVVHVIDRVLLPP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1519-1555 1.68e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.52  E-value: 1.68e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 672079485  1519 CTSGHGGCSPYANCTKVaPGQRTCTCLDGYTGDGELC 1555
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2153-2188 7.02e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 7.02e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672079485  2153 CQKGHGGCSKHANCSQVGTVVTCTCLPAYEGDGWSC 2188
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 2391-2518 3.01e-06

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 48.40  E-value: 3.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  2391 ADFSTFYGMLlgyaNATqrglDFMDFLEDELIYKTLFVPVNEGF-------LDNMtLSGPD-----LELHASNATFLSAN 2458
Cdd:pfam02469    1 PGFSTFVALL----KAA----GLVDTLNGSQGPFTVFAPTNEAFaklpagtLNFL-LKDKEqlknlLKYHVVPGRLTSSD 71

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  2459 ASQGTLLPAHSGLSLFISDTGpDNISLVplapGAVVVSHvmvwDIMAFNGVIHALASPLL 2518
Cdd:pfam02469   72 LKNGGTLATLQGSKLRVNVTG-GSVTVN----GARVVQA----DIEATNGVIHVIDKVLL 122
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 391-494 5.98e-06

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 47.63  E-value: 5.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   391 QEILTTSGPFTVLVPSMFSVSAISSSN-----MNATLAQQLCRQHIIPGEHILENIgpSNTRRWWTLAGQEITVTFKNlr 465
Cdd:pfam02469   17 DTLNGSQGPFTVFAPTNEAFAKLPAGTlnfllKDKEQLKNLLKYHVVPGRLTSSDL--KNGGTLATLQGSKLRVNVTG-- 92

                           90       100       110
                   ....*....|....*....|....*....|....
gi 672079485   466 ysykyedqpQQFSIQKA-----NYIAANGVFHTV 494
Cdd:pfam02469   93 ---------GSVTVNGArvvqaDIEATNGVIHVI 117
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 955-991 8.31e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.51  E-value: 8.31e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 672079485   955 CRVGNGGCHGLATCKAVGGgQRVCTCPPHFGGDGFSC 991
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1561-1595 9.34e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.51  E-value: 9.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 672079485  1561 CLVHNGGCHVNAECIPTGPqQVSCNCREGYSGDGI 1595
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGV 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2194-2231 2.15e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 2.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 672079485  2194 CLDGHrGGCSEHADCFNTgPNTRRCECHTGYVGDGLQC 2231
Cdd:pfam12947    1 CSDNN-GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 392-494 5.50e-05

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 46.05  E-value: 5.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  392 EILTTSGPFTVLVPS--------MFSVSAISSSNMNATLAQQLcRQHIIPGEHILENIGPSNTRRwwTLAGQEITVTFKN 463
Cdd:COG2335    57 DTLSGEGPFTVFAPTdaafaalpAGTLDALLKPENKATLTKIL-TYHVVPGKVTAADLKDGKTLT--TLQGQTLTVTVSG 133

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 672079485  464 lrysykyedqpQQFSIQKANYI-----AANGVFHTV 494
Cdd:COG2335   134 -----------GGVTVNGANVItadieASNGVIHVI 158
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1604-1641 6.33e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 6.33e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 672079485  1604 CSQNNGGCSPYAVCKSTgDGQRTCSCDSTHTvGDGITC 1641
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYT-GDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 918-949 1.81e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 1.81e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672079485   918 GGCHADALCSYVgPGQSRCTCKLGFAGDGYEC 949
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 2383-2518 4.13e-04

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 43.36  E-value: 4.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2383 LLDVLAATADFSTFYGMLlgyaNATqrglDFMDFLEDELIYkTLFVPVNEGF-------LDNMTLSGPDLEL------HA 2449
Cdd:COG2335    33 IVETAANNPDFSTLVAAL----KAA----GLVDTLSGEGPF-TVFAPTDAAFaalpagtLDALLKPENKATLtkiltyHV 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672079485 2450 SNATFLSANASQGTLLPAHSGLSLFISDTGpdnislvplapGAVVVSHVMVW--DIMAFNGVIHALASPLL 2518
Cdd:COG2335   104 VPGKVTAADLKDGKTLTTLQGQTLTVTVSG-----------GGVTVNGANVItaDIEASNGVIHVIDKVLL 163
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 834-863 7.68e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 7.68e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 672079485   834 PCHPDAHCVIQEGVARCVCHDGFEGNGFSC 863
Cdd:pfam12947    7 GCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1224-1313 3.04e-03

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 39.27  E-value: 3.04e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   1224 TIFVPTNHSLE--TQGNKSILG---IDIVRHHVILGeALSVEVLRKGGHRNSLLGPAHWLVFYNHSGQPEVNHVPLEGPL 1298
Cdd:smart00554    1 TVFAPTDEAFQklPPDLNSLLAdklKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARIVEAD 79

                            90
                    ....*....|....*
gi 672079485   1299 LEAPGSALFGLSGIL 1313
Cdd:smart00554   80 IAATNGVVHVIDRVL 94
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2036-2081 3.11e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.72  E-value: 3.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 672079485 2036 PCSGHGVCLDG-ISGSGQCNCHPGFAGTACELCAPGAFGPQCQACRC 2081
Cdd:cd00055     3 DCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
2050-2079 5.18e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 5.18e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 672079485   2050 SGQCNCHPGFAGTACELCAPGAFGPQCQAC 2079
Cdd:smart00180   17 TGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1199-1313 6.80e-03

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 38.77  E-value: 6.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1199 PAFRLFGEQLKHHKLVAQI-EAAKAYTIFVPTNHSLE--TQGNKSILGID------IVRHHVILGEALSvEVLRKGGHRN 1269
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLnGSQGPFTVFAPTNEAFAklPAGTLNFLLKDkeqlknLLKYHVVPGRLTS-SDLKNGGTLA 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 672079485  1270 SLLGPAhwLVFYNHSGQPEVNHVPLEGPLLEAPGSALFGLSGIL 1313
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVL 121
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 2266-2358 6.44e-46

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 160.71  E-value: 6.44e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2266 GVFHIQATSGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISLGV 2345
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 672079485 2346 RKNLSERWDAYCY 2358
Cdd:cd03515    81 RLNLSERWDAYCY 93
LINK smart00445
Link (Hyaluronan-binding);
2264-2359 3.82e-35

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 130.15  E-value: 3.82e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   2264 QAGVFHIQATsGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISL 2343
Cdd:smart00445    1 DGGVFHVEKN-GRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQY 79

                            90
                    ....*....|....*.
gi 672079485   2344 GVRKNLSeRWDAYCYR 2359
Cdd:smart00445   80 GFPDPTS-RYDAYCFN 94
Xlink pfam00193
Extracellular link domain;
2266-2358 3.29e-34

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 127.30  E-value: 3.29e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  2266 GVFHIQAtSGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISLGV 2345
Cdd:pfam00193    1 GVFHLES-PGRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 672079485  2346 RKNLSERWDAYCY 2358
Cdd:pfam00193   80 RDPLSERYDAYCY 92
Link_Domain cd01102
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 2266-2358 6.51e-30

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


Pssm-ID: 238534  Cd Length: 92  Bit Score: 114.82  E-value: 6.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2266 GVFHIQATSGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISLGV 2345
Cdd:cd01102     1 VVFHLESQNGRYKLTFAEAALACKARGAHLATPGQLEAAWQDGFDVCTAGWLADGSVRYPIVTSRPNCGGRNPGVRSYGN 80

                          90
                  ....*....|...
gi 672079485 2346 RKNlSERWDAYCY 2358
Cdd:cd01102    81 PAP-SGRYDAYCF 92
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 502-647 1.56e-27

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 110.77  E-value: 1.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  502 PPPLPGDPKKTVGQILASTEAFTRFETILENCGLPAMLDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAG-LSKLQELVRY 580
Cdd:COG2335    22 AEGAAMAPTKNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPEnKATLTKILTY 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672079485  581 HIYNhGQLTVEKLISKGRFLTMANQVLTVNISeEGRILLGpeGVPVRRVDVPAANGVIHMLEGILLP 647
Cdd:COG2335   102 HVVP-GKVTAADLKDGKTLTTLQGQTLTVTVS-GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1666-1770 2.34e-25

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 103.10  E-value: 2.34e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1666 KELKG-DGPFTIFVPHSDLISNMSQGELARMRAHRQL---VFRYHVLGCRkLGSQELLDQGYVTALSGHTLRISEREGSI 1741
Cdd:pfam02469   17 DTLNGsQGPFTVFAPTNEAFAKLPAGTLNFLLKDKEQlknLLKYHVVPGR-LTSSDLKNGGTLATLQGSKLRVNVTGGSV 95

                           90       100
                   ....*....|....*....|....*....
gi 672079485  1742 YLNDfARVVSSDHEAVNGVLHFIDRVLLP 1770
Cdd:pfam02469   96 TVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1796-1926 7.36e-25

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 101.56  E-value: 7.36e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1796 QYKIFSRLLTVAGLLPMLQDaSHRPFTMLWPTDSALEALSPDRKNWLYheDHRDKLAAILRGHVIRNiEASASDLPNLGQ 1875
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNG-SQGPFTVFAPTNEAFAKLPAGTLNFLL--KDKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 672079485  1876 LRTMHGNTISFSCglaRPGELMVgeNEARIVQRYLLFEGGLAYGIDQLLEP 1926
Cdd:pfam02469   78 LATLQGSKLRVNV---TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 523-647 3.35e-21

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 91.16  E-value: 3.35e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   523 FTRFETILENCGLPAMLDGP-GPFTVFAPSNEAVDSLRDGRLIYLFtAGLSKLQELVRYHIYNhGQLTVEKLISKGRFLT 601
Cdd:pfam02469    3 FSTFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLL-KDKEQLKNLLKYHVVP-GRLTSSDLKNGGTLAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 672079485   602 MANQVLTVNIsEEGRILLgpEGVPVRRVDVPAANGVIHMLEGILLP 647
Cdd:pfam02469   81 LQGSKLRVNV-TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Link_domain_CSPGs_modules_2_4 cd03520
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules ...
 2267-2358 1.35e-20

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) having link modules 3 and 4 which lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239597  Cd Length: 96  Bit Score: 88.52  E-value: 1.35e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2267 VFHIqatSGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISLGVR 2346
Cdd:cd03520     2 VFYA---TAPEKFTFQEARAECRSLGAVLATTGQLYAAWRQGLDQCDPGWLADGSVRYPISTPRPQCGGGLPGVRTLYRF 78

                          90
                  ....*....|....*...
gi 672079485 2347 KNL------SERWDAYCY 2358
Cdd:cd03520    79 PNQtgfpdpHSRFDAYCF 96
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
546-648 8.29e-20

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 86.26  E-value: 8.29e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485    546 TVFAPSNEAVDSLRDGRliYLFTAglSKLQELVRYHIYNhGQLTVEKLISKGRFLTMANQVLTVNISEeGRILLGPEGVP 625
Cdd:smart00554    1 TVFAPTDEAFQKLPPDL--NSLLA--DKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSG-GSGTVTVNGAR 74

                            90       100
                    ....*....|....*....|...
gi 672079485    626 VRRVDVPAANGVIHMLEGILLPP 648
Cdd:smart00554   75 IVEADIAATNGVVHVIDRVLLPP 97
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 2267-2358 5.93e-19

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239595  Cd Length: 95  Bit Score: 84.02  E-value: 5.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2267 VFHIQATSGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRV--GVISLG 2344
Cdd:cd03518     2 VFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGGKRTvpGLRSYG 81

                          90
                  ....*....|....
gi 672079485 2345 VRKNLSERWDAYCY 2358
Cdd:cd03518    82 ERDKMLSRYDAFCF 95
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1675-1771 1.25e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 83.18  E-value: 1.25e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   1675 TIFVPHSDLISNMSQGELARMRAHRQLVFRYHVLGcRKLGSQELLDQGYVTALSGHTLRISERE--GSIYLNDfARVVSS 1752
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVEA 78

                            90
                    ....*....|....*....
gi 672079485   1753 DHEAVNGVLHFIDRVLLPP 1771
Cdd:smart00554   79 DIAATNGVVHVIDRVLLPP 97
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1668-1770 1.50e-18

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 84.96  E-value: 1.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 1668 LKGDGPFTIFVPHSDLISNMSQGELARM-----RAHRQLVFRYHVLGcRKLGSQELLDQGYVTALSGHTLRISEREGSIY 1742
Cdd:COG2335    59 LSGEGPFTVFAPTDAAFAALPAGTLDALlkpenKATLTKILTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGGGVT 137

                          90       100
                  ....*....|....*....|....*...
gi 672079485 1743 LNDfARVVSSDHEAVNGVLHFIDRVLLP 1770
Cdd:COG2335   138 VNG-ANVITADIEASNGVIHVIDKVLLP 164
Link_domain_CD44_like cd03516
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates ...
 2265-2362 5.04e-18

This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding domain of CD44 is an extended domain comprised of a single link module flanked with N-and C- extensions. These extensions are essential for folding and for functional activity. This group also contains the cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) and lymph vessel endothelial receptor-1 (LYVE-1). CRSBP-1 is a cell surface binding protein for the CRS motif of PDGF-BB (platelet-derived growth factor-BB) and is responsible for the cell surface retention of PDGF-BB in SSV-transformed cells. CRSBP-1 may play a role in autocrine regulation of cell growth mediated by CRS containing growth regulators. LYVE-1 is preferentially expressed on the lymphatic endothelium and is used as a molecular marker for the detection and characterization of lymphatic vessels in tumors.


Pssm-ID: 239593  Cd Length: 144  Bit Score: 82.89  E-value: 5.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2265 AGVFHIQaTSGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISLG 2344
Cdd:cd03516     6 MGVFLVE-KNGRYSLNFTEAKEACRALGLTLASKAQVETALKFGFETCRYGWVEDGFVVIPRIDPNPLCGKNGTGVYILN 84

                          90
                  ....*....|....*...
gi 672079485 2345 VrkNLSERWDAYCYRVRD 2362
Cdd:cd03516    85 S--NLSSRYDAYCYNSSD 100
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1822-1927 2.16e-17

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 79.33  E-value: 2.16e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   1822 TMLWPTDSALEALSPDRKNWLyhedhRDKLAAILRGHVIRNiEASASDLPNLGQLRTMHGNTISFSCglaRPGELMVGEN 1901
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITR---SGGSGTVTVN 71

                            90       100
                    ....*....|....*....|....*.
gi 672079485   1902 EARIVQRYLLFEGGLAYGIDQLLEPP 1927
Cdd:smart00554   72 GARIVEADIAATNGVVHVIDRVLLPP 97
Link_domain_CSPGs_modules_1_3 cd03517
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third ...
 2267-2358 1.68e-16

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. In addition, aggrecan contains a second globular domain (G2) which contains link modules 3 and 4. G2 appears to lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239594  Cd Length: 95  Bit Score: 77.06  E-value: 1.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2267 VFHIQATSGPYGLTFSEAKEACEDQGADLASLPQLSAAQQLGFHVCFLGWLANGSAAHPVVTPAADCGNNR---VGVISL 2343
Cdd:cd03517     2 VFHYRDATARYALTFPRAQRACLDISAQIATPEQLLAAYEDGFEQCDAGWLADQTVRYPIQTPREGCYGDMdgfPGVRNY 81

                          90
                  ....*....|....*
gi 672079485 2344 GVRkNLSERWDAYCY 2358
Cdd:cd03517    82 GVR-DPDELYDVYCY 95
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1788-1926 4.51e-15

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 74.94  E-value: 4.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 1788 VTAAAESFQYKIFSRLLTVAGLLPMLQDAshRPFTMLWPTDSALEALSPD-RKNWLYHEDhRDKLAAILRGHVIRNiEAS 1866
Cdd:COG2335    34 VETAANNPDFSTLVAALKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGtLDALLKPEN-KATLTKILTYHVVPG-KVT 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 1867 ASDLPNLGQLRTMHGNTISFScglARPGELMVgeNEARIVQRYLLFEGGLAYGIDQLLEP 1926
Cdd:COG2335   110 AADLKDGKTLTTLQGQTLTVT---VSGGGVTV--NGANVITADIEASNGVIHVIDKVLLP 164
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 2276-2358 7.88e-15

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 72.07  E-value: 7.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2276 PYGLTFSEAKEACEDQGADLASLPQLSAAQQL-GFHVCFLGWLANGSAAHPVVTPAADCGNNRVGVISLGVRKNLSERWD 2354
Cdd:cd03519     8 PGKLTFSEAVAACQRDGAQIAKVGQLFAAWKFhGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFGFPDKKHKLYG 87


                  ....
gi 672079485 2355 AYCY 2358
Cdd:cd03519    88 VYCY 91
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1100-1180 1.84e-12

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 66.51  E-value: 1.84e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1100 NLVQSPPPPTLLLRAHFLQGAFSEEELArlSGQQVATLSATThWQIHNTSGRVQVQNATVDVPDLLATNGVLHIISQVLL 1179
Cdd:pfam02469   46 FLLKDKEQLKNLLKYHVVPGRLTSSDLK--NGGTLATLQGSK-LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLL 122


                   .
gi 672079485  1180 P 1180
Cdd:pfam02469  123 P 123
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1100-1180 2.82e-11

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 64.16  E-value: 2.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 1100 NLVQSPPPPTL--LLRAHFLQGAFSEEELArlSGQQVATLSATThWQIHNTSGRVQVQNATVDVPDLLATNGVLHIISQV 1177
Cdd:COG2335    85 ALLKPENKATLtkILTYHVVPGKVTAADLK--DGKTLTTLQGQT-LTVTVSGGGVTVNGANVITADIEASNGVIHVIDKV 161


                  ...
gi 672079485 1178 LLP 1180
Cdd:COG2335   162 LLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1111-1181 5.24e-11

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 61.22  E-value: 5.24e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672079485   1111 LLRAHFLQGAFSEEELarLSGQQVATLsATTHWQIH--NTSGRVQVQNATVDVPDLLATNGVLHIISQVLLPP 1181
Cdd:smart00554   28 LLLYHVVPGRLSSADL--LNGGTLPTL-AGSKLRITrsGGSGTVTVNGARIVEADIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
2425-2520 2.29e-08

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 53.91  E-value: 2.29e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   2425 TLFVPVNEGF------LDNMT--LSGPDLELHASNATFLSANASQGTLLPAHSGLSLFISDTGPDNIslvplapgaVVVS 2496
Cdd:smart00554    1 TVFAPTDEAFqklppdLNSLLadKLKNLLLYHVVPGRLSSADLLNGGTLPTLAGSKLRITRSGGSGT---------VTVN 71

                            90       100
                    ....*....|....*....|....*.
gi 672079485   2497 HVMV--WDIMAFNGVIHALASPLLTP 2520
Cdd:smart00554   72 GARIveADIAATNGVVHVIDRVLLPP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1519-1555 1.68e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.52  E-value: 1.68e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 672079485  1519 CTSGHGGCSPYANCTKVaPGQRTCTCLDGYTGDGELC 1555
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2153-2188 7.02e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 7.02e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672079485  2153 CQKGHGGCSKHANCSQVGTVVTCTCLPAYEGDGWSC 2188
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 2391-2518 3.01e-06

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 48.40  E-value: 3.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  2391 ADFSTFYGMLlgyaNATqrglDFMDFLEDELIYKTLFVPVNEGF-------LDNMtLSGPD-----LELHASNATFLSAN 2458
Cdd:pfam02469    1 PGFSTFVALL----KAA----GLVDTLNGSQGPFTVFAPTNEAFaklpagtLNFL-LKDKEqlknlLKYHVVPGRLTSSD 71

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  2459 ASQGTLLPAHSGLSLFISDTGpDNISLVplapGAVVVSHvmvwDIMAFNGVIHALASPLL 2518
Cdd:pfam02469   72 LKNGGTLATLQGSKLRVNVTG-GSVTVN----GARVVQA----DIEATNGVIHVIDKVLL 122
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 391-494 5.98e-06

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 47.63  E-value: 5.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   391 QEILTTSGPFTVLVPSMFSVSAISSSN-----MNATLAQQLCRQHIIPGEHILENIgpSNTRRWWTLAGQEITVTFKNlr 465
Cdd:pfam02469   17 DTLNGSQGPFTVFAPTNEAFAKLPAGTlnfllKDKEQLKNLLKYHVVPGRLTSSDL--KNGGTLATLQGSKLRVNVTG-- 92

                           90       100       110
                   ....*....|....*....|....*....|....
gi 672079485   466 ysykyedqpQQFSIQKA-----NYIAANGVFHTV 494
Cdd:pfam02469   93 ---------GSVTVNGArvvqaDIEATNGVIHVI 117
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 955-991 8.31e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.51  E-value: 8.31e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 672079485   955 CRVGNGGCHGLATCKAVGGgQRVCTCPPHFGGDGFSC 991
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1561-1595 9.34e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.51  E-value: 9.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 672079485  1561 CLVHNGGCHVNAECIPTGPqQVSCNCREGYSGDGI 1595
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGV 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2194-2231 2.15e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 2.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 672079485  2194 CLDGHrGGCSEHADCFNTgPNTRRCECHTGYVGDGLQC 2231
Cdd:pfam12947    1 CSDNN-GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 392-494 5.50e-05

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 46.05  E-value: 5.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  392 EILTTSGPFTVLVPS--------MFSVSAISSSNMNATLAQQLcRQHIIPGEHILENIGPSNTRRwwTLAGQEITVTFKN 463
Cdd:COG2335    57 DTLSGEGPFTVFAPTdaafaalpAGTLDALLKPENKATLTKIL-TYHVVPGKVTAADLKDGKTLT--TLQGQTLTVTVSG 133

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 672079485  464 lrysykyedqpQQFSIQKANYI-----AANGVFHTV 494
Cdd:COG2335   134 -----------GGVTVNGANVItadieASNGVIHVI 158
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1604-1641 6.33e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 6.33e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 672079485  1604 CSQNNGGCSPYAVCKSTgDGQRTCSCDSTHTvGDGITC 1641
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYT-GDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 918-949 1.81e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 1.81e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 672079485   918 GGCHADALCSYVgPGQSRCTCKLGFAGDGYEC 949
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 2383-2518 4.13e-04

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 43.36  E-value: 4.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485 2383 LLDVLAATADFSTFYGMLlgyaNATqrglDFMDFLEDELIYkTLFVPVNEGF-------LDNMTLSGPDLEL------HA 2449
Cdd:COG2335    33 IVETAANNPDFSTLVAAL----KAA----GLVDTLSGEGPF-TVFAPTDAAFaalpagtLDALLKPENKATLtkiltyHV 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672079485 2450 SNATFLSANASQGTLLPAHSGLSLFISDTGpdnislvplapGAVVVSHVMVW--DIMAFNGVIHALASPLL 2518
Cdd:COG2335   104 VPGKVTAADLKDGKTLTTLQGQTLTVTVSG-----------GGVTVNGANVItaDIEASNGVIHVIDKVLL 163
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 834-863 7.68e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 7.68e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 672079485   834 PCHPDAHCVIQEGVARCVCHDGFEGNGFSC 863
Cdd:pfam12947    7 GCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1224-1313 3.04e-03

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 39.27  E-value: 3.04e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485   1224 TIFVPTNHSLE--TQGNKSILG---IDIVRHHVILGeALSVEVLRKGGHRNSLLGPAHWLVFYNHSGQPEVNHVPLEGPL 1298
Cdd:smart00554    1 TVFAPTDEAFQklPPDLNSLLAdklKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARIVEAD 79

                            90
                    ....*....|....*
gi 672079485   1299 LEAPGSALFGLSGIL 1313
Cdd:smart00554   80 IAATNGVVHVIDRVL 94
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2036-2081 3.11e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.72  E-value: 3.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 672079485 2036 PCSGHGVCLDG-ISGSGQCNCHPGFAGTACELCAPGAFGPQCQACRC 2081
Cdd:cd00055     3 DCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
Link_domain_KIAA0527_like cd03521
Link_domain_KIAA0527_like; this domain is found in the human protein KIAA0527. Sequence-wise, ...
 2267-2329 4.89e-03

Link_domain_KIAA0527_like; this domain is found in the human protein KIAA0527. Sequence-wise, it is highly similar to the link domain. The link domain is a hyaluronan-binding (HA) domain. KIAA0527 contains a single link module. The KIAA0527 gene was originally cloned from human brain tissue.


Pssm-ID: 239598  Cd Length: 95  Bit Score: 38.76  E-value: 4.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672079485 2267 VFHIQATSGPYGLTFSEAKEACEDQGADLASLPQLS-AAQQLGFHVCFLGWLANGSAAHPVVTP 2329
Cdd:cd03521     2 LFVLELENGSQGLGLRAARQSCASLGARLASAAELRrAVVECFFSACARGWLADGTVGTTVCNP 65
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
2050-2079 5.18e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 5.18e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 672079485   2050 SGQCNCHPGFAGTACELCAPGAFGPQCQAC 2079
Cdd:smart00180   17 TGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1199-1313 6.80e-03

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 38.77  E-value: 6.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079485  1199 PAFRLFGEQLKHHKLVAQI-EAAKAYTIFVPTNHSLE--TQGNKSILGID------IVRHHVILGEALSvEVLRKGGHRN 1269
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLnGSQGPFTVFAPTNEAFAklPAGTLNFLLKDkeqlknLLKYHVVPGRLTS-SDLKNGGTLA 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 672079485  1270 SLLGPAhwLVFYNHSGQPEVNHVPLEGPLLEAPGSALFGLSGIL 1313
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVL 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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