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Conserved domains on  [gi|672079263|ref|XP_008769210|]
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tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X3 [Rattus norvegicus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10549439)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens tRNA N(3)-methylcytidine methyltransferase METTL6

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-184 3.36e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


:

Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 69.32  E-value: 3.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263   84 LEAGCGVGNCLFPLLEEDSNIFAYACDFSPRAVDYVKQH----PLYNAERCKVFQCDLTRDDlldhipPESVDAVTLIFV 159
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERlaalGLLNAVRVELFQLDLGELD------PGSFDVVVASNV 74

                          90       100
                  ....*....|....*....|....*
gi 672079263  160 LSavHPEKMHLVLLNVYKALLPPGV 184
Cdd:pfam08242  75 LH--HLADPRAVLRNIRRLLKPGGV 97
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-184 3.36e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 69.32  E-value: 3.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263   84 LEAGCGVGNCLFPLLEEDSNIFAYACDFSPRAVDYVKQH----PLYNAERCKVFQCDLTRDDlldhipPESVDAVTLIFV 159
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERlaalGLLNAVRVELFQLDLGELD------PGSFDVVVASNV 74

                          90       100
                  ....*....|....*....|....*
gi 672079263  160 LSavHPEKMHLVLLNVYKALLPPGV 184
Cdd:pfam08242  75 LH--HLADPRAVLRNIRRLLKPGGV 97
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 82-184 1.29e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263  82 TLLEAGCGVGNCLFPLLeEDSNIFAYACDFSPRAVDYVKQ-HPLYNAERCKVFQCDLTRddlLDHIPPESVDAVTLIFVL 160
Cdd:cd02440    1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKaAAALLADNVEVLKGDAEE---LPPEADESFDVIISDPPL 76

                         90       100
                 ....*....|....*....|....
gi 672079263 161 SAVHPEkMHLVLLNVYKALLPPGV 184
Cdd:cd02440   77 HHLVED-LARFLEEARRLLKPGGV 99
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 54-184 1.21e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 55.02  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263  54 TNFFKDRHWTTReFEELrsCREYEGQKLTLLEAGCGVGNCLFPLLEEDSNIfaYACDFSPRAVDYVKQHplYNAERCKVF 133
Cdd:COG2227    2 SDPDARDFWDRR-LAAL--LARLLPAGGRVLDVGCGTGRLALALARRGADV--TGVDISPEALEIARER--AAELNVDFV 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 672079263 134 QCDLTRDDLldhiPPESVDAVTLIFVLSavHPEKMHLVLLNVYKALLPPGV 184
Cdd:COG2227   75 QGDLEDLPL----EDGSFDLVICSEVLE--HLPDPAALLRELARLLKPGGL 119
 
Name Accession Description Interval E-value
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-184 3.36e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 69.32  E-value: 3.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263   84 LEAGCGVGNCLFPLLEEDSNIFAYACDFSPRAVDYVKQH----PLYNAERCKVFQCDLTRDDlldhipPESVDAVTLIFV 159
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERlaalGLLNAVRVELFQLDLGELD------PGSFDVVVASNV 74

                          90       100
                  ....*....|....*....|....*
gi 672079263  160 LSavHPEKMHLVLLNVYKALLPPGV 184
Cdd:pfam08242  75 LH--HLADPRAVLRNIRRLLKPGGV 97
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 84-181 1.89e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 61.81  E-value: 1.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263   84 LEAGCGVGNCLFPLLEEdSNIFAYACDFSPRAVDYVKQHPLYNAERCKVFQCDLTRDDLLDhippESVDAVTLIFVLSAV 163
Cdd:pfam13649   2 LDLGCGTGRLTLALARR-GGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPD----GSFDLVVSSGVLHHL 76

                          90
                  ....*....|....*...
gi 672079263  164 HPEKMHLVLLNVYKALLP 181
Cdd:pfam13649  77 PDPDLEAALREIARVLKP 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 82-184 1.29e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263  82 TLLEAGCGVGNCLFPLLeEDSNIFAYACDFSPRAVDYVKQ-HPLYNAERCKVFQCDLTRddlLDHIPPESVDAVTLIFVL 160
Cdd:cd02440    1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKaAAALLADNVEVLKGDAEE---LPPEADESFDVIISDPPL 76

                         90       100
                 ....*....|....*....|....
gi 672079263 161 SAVHPEkMHLVLLNVYKALLPPGV 184
Cdd:cd02440   77 HHLVED-LARFLEEARRLLKPGGV 99
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 54-184 1.21e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 55.02  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263  54 TNFFKDRHWTTReFEELrsCREYEGQKLTLLEAGCGVGNCLFPLLEEDSNIfaYACDFSPRAVDYVKQHplYNAERCKVF 133
Cdd:COG2227    2 SDPDARDFWDRR-LAAL--LARLLPAGGRVLDVGCGTGRLALALARRGADV--TGVDISPEALEIARER--AAELNVDFV 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 672079263 134 QCDLTRDDLldhiPPESVDAVTLIFVLSavHPEKMHLVLLNVYKALLPPGV 184
Cdd:COG2227   75 QGDLEDLPL----EDGSFDLVICSEVLE--HLPDPAALLRELARLLKPGGL 119
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 82-184 4.92e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 50.76  E-value: 4.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263  82 TLLEAGCGVGNCLFPLLEEDSNIfaYACDFSPRAVDYVKQHPLYNAERCKVFQCDLTRDDLldhiPPESVDAVTLIFVLS 161
Cdd:COG2226   25 RVLDLGCGTGRLALALAERGARV--TGVDISPEMLELARERAAEAGLNVEFVVGDAEDLPF----PDGSFDLVISSFVLH 98

                         90       100
                 ....*....|....*....|....
gi 672079263 162 AV-HPEKmhlVLLNVYKALLPPGV 184
Cdd:COG2226   99 HLpDPER---ALAEIARVLKPGGR 119
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
81-184 9.38e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 48.07  E-value: 9.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263  81 LTLLEAGCGVGNCLFPLLEEDSNIfaYACDFSPRAVDYVKQHPLYNAerckVFQCDLTRDDlldhIPPESVDAVTLIFVL 160
Cdd:COG4976   48 GRVLDLGCGTGLLGEALRPRGYRL--TGVDLSEEMLAKAREKGVYDR----LLVADLADLA----EPDGRFDLIVAADVL 117

                         90       100
                 ....*....|....*....|....
gi 672079263 161 SavHPEKMHLVLLNVYKALLPPGV 184
Cdd:COG4976  118 T--YLGDLAAVFAGVARALKPGGL 139
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-184 3.75e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 44.19  E-value: 3.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263   84 LEAGCGVGNCLFPLLEEDSNIfaYACDFSPRAVDYVKQHplYNAERCKVFQCDLTRDDLLDhippESVDAVTLIFVLSAV 163
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARV--TGVDISPEMLELAREK--APREGLTFVVGDAEDLPFPD----NSFDLVLSSEVLHHV 72

                          90       100
                  ....*....|....*....|..
gi 672079263  164 H-PEKmhlVLLNVYKALLPPGV 184
Cdd:pfam08241  73 EdPER---ALREIARVLKPGGI 91
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 82-183 1.06e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 41.45  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263  82 TLLEAGCGVGNCLFPLLEEdSNIFAYACDFSPRAVDYVKQ----HPLynAERCKVFQCDLTrddllDHIPPESVDAVTLI 157
Cdd:COG2230   54 RVLDIGCGWGGLALYLARR-YGVRVTGVTLSPEQLEYAREraaeAGL--ADRVEVRLADYR-----DLPADGQFDAIVSI 125

                         90       100
                 ....*....|....*....|....*.
gi 672079263 158 FVLSAVHPEKmHLVLLNVYKALLPPG 183
Cdd:COG2230  126 GMFEHVGPEN-YPAYFAKVARLLKPG 150
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
82-184 1.97e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 39.81  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672079263  82 TLLEAGCGVGNCLFPLLEEDSNIFAYACDFSPRAVDYVKQH-PlynaerckvfQCDLTRDDLLDHIPPESVDAVTLIFVL 160
Cdd:COG4106    4 RVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARlP----------NVRFVVADLRDLDPPEPFDLVVSNAAL 73

                         90       100
                 ....*....|....*....|....
gi 672079263 161 SavHPEKMHLVLLNVYKALLPPGV 184
Cdd:COG4106   74 H--WLPDHAALLARLAAALAPGGV 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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