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Conserved domains on  [gi|672063724|ref|XP_008764923|]
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xin actin-binding repeat-containing protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

Xin and PHA03247 domain-containing protein( domain architecture ID 10547186)

Xin and PHA03247 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 902-1293 1.53e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724  902 ETGQGLVALTAYSLQPQPTSrGPERSSVQLLASCIDKGELHSLPSLRWEPPTDSSSVPVTEETQRLPPTESI--IRVTPL 979
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTpePAPHAL 2715

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724  980 DSTMKMGHLRVSGSTPCPPLPRAAGKVVLPNGrPGAPLQEARKQVDISHAGQKGKA-----ASGRPEGTIAPPLGSGAPN 1054
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGPARPARPPTTAGPPAPAppaapAAGPPRRLTRPAVASLSES 2794

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1055 LQEAMQNLRLATAEAQSLHQQ----VLSRHAQGSDPAATSISAQDVLQ---VPTPTTTQGSIMPvaGRDARITAVPRKVS 1127
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAaalpPAASPAGPLPPPTSAQPTAPPPPpgpPPPSLPLGGSVAP--GGDVRRRPPSRSPA 2872

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1128 gdnkAVPRGLPRgrvtiqdgiyaaHPVRTSDLPGAIQPSEKEPQPRDSPPQADQGQSPRPEyhepgghsqrawgplgkvM 1207
Cdd:PHA03247 2873 ----AKPAAPAR------------PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP------------------Q 2918

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1208 PQIWPECLQAADTSLKTVPLTHHTLTPKPQAAGDSLHSHNASPPTLPAAVTEEPDHPAQGHHQKDSVQQASKPLREPlLH 1287
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP-LT 2997


                  ....*.
gi 672063724 1288 SHNRPA 1293
Cdd:PHA03247 2998 GHSLSR 3003
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 510-525 2.93e-05

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 42.33  E-value: 2.93e-05
                           10
                   ....*....|....*.
gi 672063724   510 GDVQGYKWMFETQPLD 525
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 548-563 4.78e-05

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 41.56  E-value: 4.78e-05
                           10
                   ....*....|....*.
gi 672063724   548 GDVGTTRWLFETQPLE 563
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 375-390 3.62e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 39.25  E-value: 3.62e-04
                           10
                   ....*....|....*.
gi 672063724   375 GDVRSTLWLFETKPLD 390
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 302-316 4.11e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 38.86  E-value: 4.11e-04
                           10
                   ....*....|....*
gi 672063724   302 DVSATRWIFETQPLD 316
Cdd:pfam08043    2 DVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 89-104 1.52e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 37.32  E-value: 1.52e-03
                           10
                   ....*....|....*.
gi 672063724    89 GDVQCMRWIFENWSLD 104
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 592-606 2.04e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 36.94  E-value: 2.04e-03
                           10
                   ....*....|....*
gi 672063724   592 GDVQTIRWLFETYPM 606
Cdd:pfam08043    1 GDVKTTRWLFETQPL 15
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 185-200 5.66e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


:

Pssm-ID: 462346  Cd Length: 16  Bit Score: 35.78  E-value: 5.66e-03
                           10
                   ....*....|....*.
gi 672063724   185 GDVQGTRKLFETKPLD 200
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 902-1293 1.53e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724  902 ETGQGLVALTAYSLQPQPTSrGPERSSVQLLASCIDKGELHSLPSLRWEPPTDSSSVPVTEETQRLPPTESI--IRVTPL 979
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTpePAPHAL 2715

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724  980 DSTMKMGHLRVSGSTPCPPLPRAAGKVVLPNGrPGAPLQEARKQVDISHAGQKGKA-----ASGRPEGTIAPPLGSGAPN 1054
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGPARPARPPTTAGPPAPAppaapAAGPPRRLTRPAVASLSES 2794

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1055 LQEAMQNLRLATAEAQSLHQQ----VLSRHAQGSDPAATSISAQDVLQ---VPTPTTTQGSIMPvaGRDARITAVPRKVS 1127
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAaalpPAASPAGPLPPPTSAQPTAPPPPpgpPPPSLPLGGSVAP--GGDVRRRPPSRSPA 2872

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1128 gdnkAVPRGLPRgrvtiqdgiyaaHPVRTSDLPGAIQPSEKEPQPRDSPPQADQGQSPRPEyhepgghsqrawgplgkvM 1207
Cdd:PHA03247 2873 ----AKPAAPAR------------PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP------------------Q 2918

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1208 PQIWPECLQAADTSLKTVPLTHHTLTPKPQAAGDSLHSHNASPPTLPAAVTEEPDHPAQGHHQKDSVQQASKPLREPlLH 1287
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP-LT 2997


                  ....*.
gi 672063724 1288 SHNRPA 1293
Cdd:PHA03247 2998 GHSLSR 3003
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 510-525 2.93e-05

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 42.33  E-value: 2.93e-05
                           10
                   ....*....|....*.
gi 672063724   510 GDVQGYKWMFETQPLD 525
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 548-563 4.78e-05

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 41.56  E-value: 4.78e-05
                           10
                   ....*....|....*.
gi 672063724   548 GDVGTTRWLFETQPLE 563
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 375-390 3.62e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 39.25  E-value: 3.62e-04
                           10
                   ....*....|....*.
gi 672063724   375 GDVRSTLWLFETKPLD 390
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 302-316 4.11e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 38.86  E-value: 4.11e-04
                           10
                   ....*....|....*
gi 672063724   302 DVSATRWIFETQPLD 316
Cdd:pfam08043    2 DVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 89-104 1.52e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 37.32  E-value: 1.52e-03
                           10
                   ....*....|....*.
gi 672063724    89 GDVQCMRWIFENWSLD 104
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 592-606 2.04e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 36.94  E-value: 2.04e-03
                           10
                   ....*....|....*
gi 672063724   592 GDVQTIRWLFETYPM 606
Cdd:pfam08043    1 GDVKTTRWLFETQPL 15
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 185-200 5.66e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 35.78  E-value: 5.66e-03
                           10
                   ....*....|....*.
gi 672063724   185 GDVQGTRKLFETKPLD 200
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 902-1293 1.53e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724  902 ETGQGLVALTAYSLQPQPTSrGPERSSVQLLASCIDKGELHSLPSLRWEPPTDSSSVPVTEETQRLPPTESI--IRVTPL 979
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTpePAPHAL 2715

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724  980 DSTMKMGHLRVSGSTPCPPLPRAAGKVVLPNGrPGAPLQEARKQVDISHAGQKGKA-----ASGRPEGTIAPPLGSGAPN 1054
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGPARPARPPTTAGPPAPAppaapAAGPPRRLTRPAVASLSES 2794

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1055 LQEAMQNLRLATAEAQSLHQQ----VLSRHAQGSDPAATSISAQDVLQ---VPTPTTTQGSIMPvaGRDARITAVPRKVS 1127
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAaalpPAASPAGPLPPPTSAQPTAPPPPpgpPPPSLPLGGSVAP--GGDVRRRPPSRSPA 2872

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1128 gdnkAVPRGLPRgrvtiqdgiyaaHPVRTSDLPGAIQPSEKEPQPRDSPPQADQGQSPRPEyhepgghsqrawgplgkvM 1207
Cdd:PHA03247 2873 ----AKPAAPAR------------PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP------------------Q 2918

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1208 PQIWPECLQAADTSLKTVPLTHHTLTPKPQAAGDSLHSHNASPPTLPAAVTEEPDHPAQGHHQKDSVQQASKPLREPlLH 1287
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP-LT 2997


                  ....*.
gi 672063724 1288 SHNRPA 1293
Cdd:PHA03247 2998 GHSLSR 3003
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 510-525 2.93e-05

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 42.33  E-value: 2.93e-05
                           10
                   ....*....|....*.
gi 672063724   510 GDVQGYKWMFETQPLD 525
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 548-563 4.78e-05

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 41.56  E-value: 4.78e-05
                           10
                   ....*....|....*.
gi 672063724   548 GDVGTTRWLFETQPLE 563
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 375-390 3.62e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 39.25  E-value: 3.62e-04
                           10
                   ....*....|....*.
gi 672063724   375 GDVRSTLWLFETKPLD 390
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 302-316 4.11e-04

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 38.86  E-value: 4.11e-04
                           10
                   ....*....|....*
gi 672063724   302 DVSATRWIFETQPLD 316
Cdd:pfam08043    2 DVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 89-104 1.52e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 37.32  E-value: 1.52e-03
                           10
                   ....*....|....*.
gi 672063724    89 GDVQCMRWIFENWSLD 104
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 592-606 2.04e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 36.94  E-value: 2.04e-03
                           10
                   ....*....|....*
gi 672063724   592 GDVQTIRWLFETYPM 606
Cdd:pfam08043    1 GDVKTTRWLFETQPL 15
PHA03247 PHA03247
large tegument protein UL36; Provisional
 993-1428 4.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724  993 STPCP-PLPRAAGKVVLPNG-RPGAPLQEARKQ--VDISHAGQKGKAASGRPEGTIA--PPLGSGAPNLQEAMQNLRLAT 1066
Cdd:PHA03247 2567 SVPPPrPAPRPSEPAVTSRArRPDAPPQSARPRapVDDRGDPRGPAPPSPLPPDTHApdPPPPSPSPAANEPDPHPPPTV 2646

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1067 AEAQ-----------SLHQQV--LSRHAQGSDPA---------ATSISAQDVLQVPTPTTTQGSIMPVAGRDARITAVPR 1124
Cdd:PHA03247 2647 PPPErprddpapgrvSRPRRArrLGRAAQASSPPqrprrraarPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPA 2726

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1125 KVSGDNKA-----VPRGLPRGRVTIQDGIYAAHPVRTSDLPGAIQPSEKE--PQPRDSPPQADQGQSPR---PEYHEPGG 1194
Cdd:PHA03247 2727 AARQASPAlpaapAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAagPPRRLTRPAVASLSESReslPSPWDPAD 2806

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1195 HSQRAWGPLGKVMPQIWPECLQAADTS-LKTVPLTHHTLTPKPQAAGDSLHS----HNASPPTLPAAVTEEPDHPAQGHH 1269
Cdd:PHA03247 2807 PPAAVLAPAAALPPAASPAGPLPPPTSaQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRL 2886

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1270 QKDSVQQASKPLREPllhsHNRPAGQKTLEGSETKLSKAEstvlprkkppVPPKPAHLSQVHPPHRLPKPLAASASISEA 1349
Cdd:PHA03247 2887 ARPAVSRSTESFALP----PDQPERPPQPQAPPPPQPQPQ----------PPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1350 GQDhKPGEP----GVANPGSAKAPTIAGQGCLPLAECSKGQKQPMRQYPLSTTASRPSGGQTSNSNSQSPESRKLTILNN 1425
Cdd:PHA03247 2953 GEP-SGAVPqpwlGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPP 3031


                  ...
gi 672063724 1426 DND 1428
Cdd:PHA03247 3032 DDT 3034
Xin pfam08043
Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This ...
 185-200 5.66e-03

Xin repeat; The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein Swiss:Q702N9. The homologs in mouse and chicken localize in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localize with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.


Pssm-ID: 462346  Cd Length: 16  Bit Score: 35.78  E-value: 5.66e-03
                           10
                   ....*....|....*.
gi 672063724   185 GDVQGTRKLFETKPLD 200
Cdd:pfam08043    1 GDVKTTRWLFETQPLD 16
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1086-1456 6.94e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 6.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1086 PAATSISaqdvlqVPTPTTTQGSIMP-VAGRDARITAVPRKVSGDNKAVPRGLPRGRVTIQDGIYAAHPVR---TSDLPG 1161
Cdd:PHA03247 2561 PAAPDRS------VPPPRPAPRPSEPaVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDpppPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1162 AIQPSEKEPQPRDSPPQADQGQSP----RPEYHEPGGHSQRAWGPLGKVMPQIWPECLqAADTSLKTVPLTHHTLTPKPQ 1237
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPgrvsRPRRARRLGRAAQASSPPQRPRRRAARPTV-GSLTSLADPPPPPPTPEPAPH 2713

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1238 AAGDSLhshnASPPTLPAAVTEEPDHPAQghhqkdsvqqaskplrepllhshnrPAGQKTLEGSETKLSKAESTVLPRKK 1317
Cdd:PHA03247 2714 ALVSAT----PLPPGPAAARQASPALPAA-------------------------PAPPAVPAGPATPGGPARPARPPTTA 2764

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672063724 1318 PPVPPKPAHLSQVHPPHRLPKPLAASASISEAG----QDHKPGEPGVANPGSAKAPTIAGQGCLPLAECSKGQKQPMRQY 1393
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESlpspWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672063724 1394 PLSTT-------------ASRPSGGQTSN--SNSQSPESRKLTilnndndvSPPQKHPSSPKQQPMDG-SKQRTPESPE 1456
Cdd:PHA03247 2845 PPPPSlplggsvapggdvRRRPPSRSPAAkpAAPARPPVRRLA--------RPAVSRSTESFALPPDQpERPPQPQAPP 2915
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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