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Conserved domains on  [gi|667300539|ref|XP_008580996|]
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PREDICTED: nidogen-1 [Galeopterus variegatus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11272459)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 363-594 2.86e-116

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


:

Pssm-ID: 238158  Cd Length: 224  Bit Score: 359.70  E-value: 2.86e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  363 GSPQRVNGKVKGRIFVGtsQVPVVFENTDLHSYVVMNHGRSYTAISTIPETLGYSLLPLAPIGGIIGWMFAVEQDGFRNG 442
Cdd:cd00255     1 GIPQRVNGKVSGNINVG--QSPVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  443 FSITGGEFTRQAEVTFVGHPGKLVIKQQFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSHT-VITSSSTR 521
Cdd:cd00255    79 FSLTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPgVLTSSSTR 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 667300539  522 EYTVTEPerdgaAPSHTYTYQWRQTITFQDCVHDnsRPALPSTQQLSVDSVFVLYNEDERILRYALSNSIGPV 594
Cdd:cd00255   159 EYTVDEG-----GESQTLSYQWNQTITYEECPHD--DEAAPDLQQLLVARIFALYNPEEEILRFAITNSIGPG 224
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
40-203 1.20e-46

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 164.14  E-value: 1.20e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539     40 PFLADLDTtDGLGKVYYREDLSPFITQLAAQYVQRGFPE-VSFQPSSVVVVTWESVAPYQGPSRNPAqegkrNTFQAVLA 118
Cdd:smart00539    1 PFWADADT-EGTGKVYYRETTDHAILDRATESVREGFTDmGGFRAKSVVIVTWENVAAYGSQSSDGT-----NTFQAVLA 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539    119 SSDVSSYAIFLYPEDGLQFHTTFSKTDknQVPAVVAFCQGSVGFLwksdgvYNIFANDRESIENLAKSSNSGQQGIWVFE 198
Cdd:smart00539   75 TDGSRTYAIFLYPSLGWTSDTTAGGDD--GVRARAGFNGGDGTFS------YTLPASGEENIKNLAEGSNVGIPGRWMFR 146


                    ....*
gi 667300539    199 IGSPA 203
Cdd:smart00539  147 VDGAE 151
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 783-853 9.37e-28

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 107.00  E-value: 9.37e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 667300539   783 CQQEREHILGAADAvdlqRPRPPGLFVPECDEHGNYVPTQCHGSTGYCWCVDRDGRELEGTRTRPGMrPPC 853
Cdd:pfam00086    1 CERERARALEQAAS----GRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGD-PDC 66
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 948-989 2.29e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 65.32  E-value: 2.29e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 667300539    948 TIVRQDLGSPEGIAVDHLGRNIFWTDSLLDRIEVAKLDGSQR 989
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 745-773 1.26e-11

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 59.92  E-value: 1.26e-11
                           10        20
                   ....*....|....*....|....*....
gi 667300539   745 CHPDAFCYNTPGSFTCQCKPGYWGDGFRC 773
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 990-1034 1.53e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.53e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 667300539    990 RVLLETDLVNPRGIVTDSVRGNLYWTDWNRDspKIETSYMDGTNR 1034
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1146-1170 2.85e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.40  E-value: 2.85e-09
                           10        20
                   ....*....|....*....|....*
gi 667300539  1146 CSVNNGGCTHLCLATPGSRTCRCPD 1170
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 926-964 6.87e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 6.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 667300539   926 VYWTDIGE-PSIGRASLHGGEPSTIVRQDLGSPEGIAVDH 964
Cdd:pfam00058    3 LYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 696-734 4.13e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.29  E-value: 4.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 667300539   696 CTTGLHDCDipQRARCVYTGGSsYTCSCLPGFSGDGRAC 734
Cdd:pfam12947    1 CSDNNGGCH--PNATCTNTGGS-FTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 324-359 5.75e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 5.75e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 667300539   324 CANNRHQCSVHAECTDYTTGFCCSCVAGYTGNGRQC 359
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 606-642 2.58e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.98  E-value: 2.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 667300539   606 CYIGTHGCDTNAACRPGPGtQFTCECSIGFRGDGRIC 642
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
644-685 4.55e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 4.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 667300539    644 DIDECAEqPSVCGSNAICNNHPATFRCECMEGfrFSDEGTCV 685
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPG--YTDGRNCE 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1035-1071 7.85e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 7.85e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 667300539   1035 RILVQDDLGLPNGLTFDTFSSQLCWVDAGTHRAECLN 1071
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVAN 37
 
Name Accession Description Interval E-value
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 363-594 2.86e-116

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 359.70  E-value: 2.86e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  363 GSPQRVNGKVKGRIFVGtsQVPVVFENTDLHSYVVMNHGRSYTAISTIPETLGYSLLPLAPIGGIIGWMFAVEQDGFRNG 442
Cdd:cd00255     1 GIPQRVNGKVSGNINVG--QSPVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  443 FSITGGEFTRQAEVTFVGHPGKLVIKQQFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSHT-VITSSSTR 521
Cdd:cd00255    79 FSLTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPgVLTSSSTR 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 667300539  522 EYTVTEPerdgaAPSHTYTYQWRQTITFQDCVHDnsRPALPSTQQLSVDSVFVLYNEDERILRYALSNSIGPV 594
Cdd:cd00255   159 EYTVDEG-----GESQTLSYQWNQTITYEECPHD--DEAAPDLQQLLVARIFALYNPEEEILRFAITNSIGPG 224
G2F smart00682
G2 nidogen domain and fibulin;
361-600 5.18e-108

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 337.88  E-value: 5.18e-108
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539    361 AEGSPQRVNGKVKGRIFVGtsQVPVVFENTDLHSYVVMNHGRSYTAISTIPETLGYSLLPLAPIGGIIGWMFAVEQDGFR 440
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVG--EFPVAFENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAV 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539    441 NGFSITGGEFTRQAEVTFvGHPGKLVIKQQFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYS-HTVITSSS 519
Cdd:smart00682   79 NGFQLTGGVFTRETEVTF-AGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTgPGVLTTSS 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539    520 TREYTVteperdgaaPSHTYTYQWRQTITFQDCVHDNsrPALPSTQQLSVDSVFVLYNEDERILRYALSNSIGPVRDGSP 599
Cdd:smart00682  158 TREYTV---------DNQTHSYTVDQTITFEECQHRD--AFPPTTQQLHVSSVFVDYNDEERVLRFAAHNSVGPGDESNQ 226


                    .
gi 667300539    600 D 600
Cdd:smart00682  227 C 227
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 363-555 9.17e-86

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 275.63  E-value: 9.17e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539   363 GSPQRVNGKVKGRIfvgtsqVPVVFENTDLHSYVVMNHGRSYTAISTIPETLGYSLLPLAPIGGIIGWMFAVEQDGFRNG 442
Cdd:pfam07474    1 GVPQRVNGKVSGTI------NGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNG 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539   443 FSITGGEFTRQAEVTFVGHPGKLVIKQQFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSHT-VITSSSTR 521
Cdd:pfam07474   75 FSLTGGVFNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPgELTSSSTR 154

                          170       180       190
                   ....*....|....*....|....*....|....
gi 667300539   522 EYTVTEPERDgaapsHTYTYQWRQTITFQDCVHD 555
Cdd:pfam07474  155 TYTVDGEGNT-----RTISYTVNQTITYQECRHA 183
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
40-203 1.20e-46

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 164.14  E-value: 1.20e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539     40 PFLADLDTtDGLGKVYYREDLSPFITQLAAQYVQRGFPE-VSFQPSSVVVVTWESVAPYQGPSRNPAqegkrNTFQAVLA 118
Cdd:smart00539    1 PFWADADT-EGTGKVYYRETTDHAILDRATESVREGFTDmGGFRAKSVVIVTWENVAAYGSQSSDGT-----NTFQAVLA 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539    119 SSDVSSYAIFLYPEDGLQFHTTFSKTDknQVPAVVAFCQGSVGFLwksdgvYNIFANDRESIENLAKSSNSGQQGIWVFE 198
Cdd:smart00539   75 TDGSRTYAIFLYPSLGWTSDTTAGGDD--GVRARAGFNGGDGTFS------YTLPASGEENIKNLAEGSNVGIPGRWMFR 146


                    ....*
gi 667300539    199 IGSPA 203
Cdd:smart00539  147 VDGAE 151
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 783-853 9.37e-28

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 107.00  E-value: 9.37e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 667300539   783 CQQEREHILGAADAvdlqRPRPPGLFVPECDEHGNYVPTQCHGSTGYCWCVDRDGRELEGTRTRPGMrPPC 853
Cdd:pfam00086    1 CERERARALEQAAS----GRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGD-PDC 66
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 110-201 3.05e-27

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 106.22  E-value: 3.05e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539   110 RNTFQAVLASSDVSSYAIFLYPEDGLQFHTTFSKTDKN---QVPAVVAFCQGSvgflwKSDGVYNIFANDRESIENLAKS 186
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGGIQWTTGKASGGTNglgGTPAQAGFSAGD-----GDGRYYELPGSGTDSIRNLTET 75

                           90
                   ....*....|....*
gi 667300539   187 SNSGQQGIWVFEIGS 201
Cdd:pfam06119   76 SNVGVPGRWVFRIDS 90
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 783-853 3.45e-25

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 99.46  E-value: 3.45e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 667300539  783 CQQEREHILGAadavdLQRPRPPGLFVPECDEHGNYVPTQCHGSTGYCWCVDRDGRELEGTRTRPGmRPPC 853
Cdd:cd00191     2 CERERASALES-----LAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG-PPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 809-855 1.06e-16

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 74.72  E-value: 1.06e-16
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 667300539    809 VPECDEHGNYVPTQCHGSTGYCWCVDRDGRELEGTRTrPGMRPPCLS 855
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRT-EGGDPDCPS 46
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 948-989 2.29e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 65.32  E-value: 2.29e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 667300539    948 TIVRQDLGSPEGIAVDHLGRNIFWTDSLLDRIEVAKLDGSQR 989
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 745-773 1.26e-11

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 59.92  E-value: 1.26e-11
                           10        20
                   ....*....|....*....|....*....
gi 667300539   745 CHPDAFCYNTPGSFTCQCKPGYWGDGFRC 773
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 990-1034 1.53e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.53e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 667300539    990 RVLLETDLVNPRGIVTDSVRGNLYWTDWNRDspKIETSYMDGTNR 1034
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1146-1170 2.85e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.40  E-value: 2.85e-09
                           10        20
                   ....*....|....*....|....*
gi 667300539  1146 CSVNNGGCTHLCLATPGSRTCRCPD 1170
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
EGF_CA smart00179
Calcium-binding EGF-like domain;
736-774 6.48e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.63  E-value: 6.48e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 667300539    736 DVDECQ-LSRCHPDAFCYNTPGSFTCQCKPGYWgDGFRCV 774
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 926-964 6.87e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 6.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 667300539   926 VYWTDIGE-PSIGRASLHGGEPSTIVRQDLGSPEGIAVDH 964
Cdd:pfam00058    3 LYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 736-774 1.93e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 1.93e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 667300539  736 DVDECQL-SRCHPDAFCYNTPGSFTCQCKPGYWGDgfRCV 774
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGR--NCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 696-734 4.13e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.29  E-value: 4.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 667300539   696 CTTGLHDCDipQRARCVYTGGSsYTCSCLPGFSGDGRAC 734
Cdd:pfam12947    1 CSDNNGGCH--PNATCTNTGGS-FTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 324-359 5.75e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 5.75e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 667300539   324 CANNRHQCSVHAECTDYTTGFCCSCVAGYTGNGRQC 359
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1010-1051 9.02e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 9.02e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 667300539  1010 GNLYWTDWNRDsPKIETSYMDGTNRRILVQDDLGLPNGLTFD 1051
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 967-1006 1.28e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.28e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 667300539   967 RNIFWTDSLLD-RIEVAKLDGSQRRVLLETDLVNPRGIVTD 1006
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 606-642 2.58e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.98  E-value: 2.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 667300539   606 CYIGTHGCDTNAACRPGPGtQFTCECSIGFRGDGRIC 642
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
644-685 4.55e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 4.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 667300539    644 DIDECAEqPSVCGSNAICNNHPATFRCECMEGfrFSDEGTCV 685
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPG--YTDGRNCE 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
847-1067 7.94e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.62  E-value: 7.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  847 PGMRPPCLSTVAPPIHQGPSVPTAVIPLPPGTHLLFAQTGKIEHLPLEGTTMKKTEAKALLHIPAKVIIGLAFDCVDKMV 926
Cdd:COG3391     3 VASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  927 YWTDIGEPSIGRASLHGGEPSTIVRQDlGSPEGIAVDHLGRNIFWTDSLLDRieVAKLDGSQRRVLLETDL-VNPRGIVT 1005
Cdd:COG3391    83 YVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVATIPVgAGPHGIAV 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 667300539 1006 DSVRGNLYWTDWnrDSPKIET--SYMDGTNRRILVQDDLG-LPNGLTFDTFSSQLCWVDAGTHRA 1067
Cdd:COG3391   160 DPDGKRLYVANS--GSNTVSVivSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNTS 222
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 916-945 1.38e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 1.38e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 667300539    916 GLAFDCVDKMVYWTDIGEPSIGRASLHGGE 945
Cdd:smart00135   13 GLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_CA pfam07645
Calcium-binding EGF domain;
644-675 1.91e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 1.91e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 667300539   644 DIDECAEQPSVCGSNAICNNHPATFRCECMEG 675
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 644-677 2.67e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.67e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 667300539  644 DIDECAEqPSVCGSNAICNNHPATFRCECMEGFR 677
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1035-1071 7.85e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 7.85e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 667300539   1035 RILVQDDLGLPNGLTFDTFSSQLCWVDAGTHRAECLN 1071
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVAN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
693-735 9.03e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 9.03e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 667300539    693 IDYCTTGlHDCDipQRARCVYTGGSsYTCSCLPGFSgDGRACQ 735
Cdd:smart00179    2 IDECASG-NPCQ--NGGTCVNTVGS-YRCECPPGYT-DGRNCE 39
 
Name Accession Description Interval E-value
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 363-594 2.86e-116

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 359.70  E-value: 2.86e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  363 GSPQRVNGKVKGRIFVGtsQVPVVFENTDLHSYVVMNHGRSYTAISTIPETLGYSLLPLAPIGGIIGWMFAVEQDGFRNG 442
Cdd:cd00255     1 GIPQRVNGKVSGNINVG--QSPVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  443 FSITGGEFTRQAEVTFVGHPGKLVIKQQFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSHT-VITSSSTR 521
Cdd:cd00255    79 FSLTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPgVLTSSSTR 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 667300539  522 EYTVTEPerdgaAPSHTYTYQWRQTITFQDCVHDnsRPALPSTQQLSVDSVFVLYNEDERILRYALSNSIGPV 594
Cdd:cd00255   159 EYTVDEG-----GESQTLSYQWNQTITYEECPHD--DEAAPDLQQLLVARIFALYNPEEEILRFAITNSIGPG 224
G2F smart00682
G2 nidogen domain and fibulin;
361-600 5.18e-108

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 337.88  E-value: 5.18e-108
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539    361 AEGSPQRVNGKVKGRIFVGtsQVPVVFENTDLHSYVVMNHGRSYTAISTIPETLGYSLLPLAPIGGIIGWMFAVEQDGFR 440
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVG--EFPVAFENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAV 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539    441 NGFSITGGEFTRQAEVTFvGHPGKLVIKQQFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYS-HTVITSSS 519
Cdd:smart00682   79 NGFQLTGGVFTRETEVTF-AGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTgPGVLTTSS 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539    520 TREYTVteperdgaaPSHTYTYQWRQTITFQDCVHDNsrPALPSTQQLSVDSVFVLYNEDERILRYALSNSIGPVRDGSP 599
Cdd:smart00682  158 TREYTV---------DNQTHSYTVDQTITFEECQHRD--AFPPTTQQLHVSSVFVDYNDEERVLRFAAHNSVGPGDESNQ 226


                    .
gi 667300539    600 D 600
Cdd:smart00682  227 C 227
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 363-555 9.17e-86

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 275.63  E-value: 9.17e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539   363 GSPQRVNGKVKGRIfvgtsqVPVVFENTDLHSYVVMNHGRSYTAISTIPETLGYSLLPLAPIGGIIGWMFAVEQDGFRNG 442
Cdd:pfam07474    1 GVPQRVNGKVSGTI------NGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNG 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539   443 FSITGGEFTRQAEVTFVGHPGKLVIKQQFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSHT-VITSSSTR 521
Cdd:pfam07474   75 FSLTGGVFNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPgELTSSSTR 154

                          170       180       190
                   ....*....|....*....|....*....|....
gi 667300539   522 EYTVTEPERDgaapsHTYTYQWRQTITFQDCVHD 555
Cdd:pfam07474  155 TYTVDGEGNT-----RTISYTVNQTITYQECRHA 183
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
40-203 1.20e-46

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 164.14  E-value: 1.20e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539     40 PFLADLDTtDGLGKVYYREDLSPFITQLAAQYVQRGFPE-VSFQPSSVVVVTWESVAPYQGPSRNPAqegkrNTFQAVLA 118
Cdd:smart00539    1 PFWADADT-EGTGKVYYRETTDHAILDRATESVREGFTDmGGFRAKSVVIVTWENVAAYGSQSSDGT-----NTFQAVLA 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539    119 SSDVSSYAIFLYPEDGLQFHTTFSKTDknQVPAVVAFCQGSVGFLwksdgvYNIFANDRESIENLAKSSNSGQQGIWVFE 198
Cdd:smart00539   75 TDGSRTYAIFLYPSLGWTSDTTAGGDD--GVRARAGFNGGDGTFS------YTLPASGEENIKNLAEGSNVGIPGRWMFR 146


                    ....*
gi 667300539    199 IGSPA 203
Cdd:smart00539  147 VDGAE 151
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 783-853 9.37e-28

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 107.00  E-value: 9.37e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 667300539   783 CQQEREHILGAADAvdlqRPRPPGLFVPECDEHGNYVPTQCHGSTGYCWCVDRDGRELEGTRTRPGMrPPC 853
Cdd:pfam00086    1 CERERARALEQAAS----GRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGD-PDC 66
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 110-201 3.05e-27

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 106.22  E-value: 3.05e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539   110 RNTFQAVLASSDVSSYAIFLYPEDGLQFHTTFSKTDKN---QVPAVVAFCQGSvgflwKSDGVYNIFANDRESIENLAKS 186
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGGIQWTTGKASGGTNglgGTPAQAGFSAGD-----GDGRYYELPGSGTDSIRNLTET 75

                           90
                   ....*....|....*
gi 667300539   187 SNSGQQGIWVFEIGS 201
Cdd:pfam06119   76 SNVGVPGRWVFRIDS 90
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 783-853 3.45e-25

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 99.46  E-value: 3.45e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 667300539  783 CQQEREHILGAadavdLQRPRPPGLFVPECDEHGNYVPTQCHGSTGYCWCVDRDGRELEGTRTRPGmRPPC 853
Cdd:cd00191     2 CERERASALES-----LAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG-PPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 809-855 1.06e-16

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 74.72  E-value: 1.06e-16
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 667300539    809 VPECDEHGNYVPTQCHGSTGYCWCVDRDGRELEGTRTrPGMRPPCLS 855
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRT-EGGDPDCPS 46
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 948-989 2.29e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 65.32  E-value: 2.29e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 667300539    948 TIVRQDLGSPEGIAVDHLGRNIFWTDSLLDRIEVAKLDGSQR 989
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 745-773 1.26e-11

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 59.92  E-value: 1.26e-11
                           10        20
                   ....*....|....*....|....*....
gi 667300539   745 CHPDAFCYNTPGSFTCQCKPGYWGDGFRC 773
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 990-1034 1.53e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.53e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 667300539    990 RVLLETDLVNPRGIVTDSVRGNLYWTDWNRDspKIETSYMDGTNR 1034
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD--VIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1146-1170 2.85e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.40  E-value: 2.85e-09
                           10        20
                   ....*....|....*....|....*
gi 667300539  1146 CSVNNGGCTHLCLATPGSRTCRCPD 1170
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
EGF_CA smart00179
Calcium-binding EGF-like domain;
736-774 6.48e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.63  E-value: 6.48e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 667300539    736 DVDECQ-LSRCHPDAFCYNTPGSFTCQCKPGYWgDGFRCV 774
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 926-964 6.87e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 6.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 667300539   926 VYWTDIGE-PSIGRASLHGGEPSTIVRQDLGSPEGIAVDH 964
Cdd:pfam00058    3 LYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 736-774 1.93e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 1.93e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 667300539  736 DVDECQL-SRCHPDAFCYNTPGSFTCQCKPGYWGDgfRCV 774
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGR--NCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 696-734 4.13e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 50.29  E-value: 4.13e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 667300539   696 CTTGLHDCDipQRARCVYTGGSsYTCSCLPGFSGDGRAC 734
Cdd:pfam12947    1 CSDNNGGCH--PNATCTNTGGS-FTCTCNDGYTGDGVTC 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 953-1108 4.28e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 4.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  953 DLGSPEGIAVDHLGrNIFWTDSLLDRIEVAKLDGSQRRVL-----LETDLVNPRGIVTDSVrGNLYWTDWNRDSPKI--- 1024
Cdd:cd05819   100 EFNGPRGIAVDSSG-NIYVADTGNHRIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRIQVfdp 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539 1025 ETSYMDGTNRRILVQDDLGLPNGLTFDtfSSQLCWV-DAGTHRAECLNPAQP------SRRKVLEGLQYPF--AVTSYGk 1095
Cdd:cd05819   178 DGNFLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYVaDSGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSglAVDSDG- 254

                         170
                  ....*....|...
gi 667300539 1096 NLYYTDWQTNSVV 1108
Cdd:cd05819   255 NLYVADTGNNRIQ 267
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 324-359 5.75e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 5.75e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 667300539   324 CANNRHQCSVHAECTDYTTGFCCSCVAGYTGNGRQC 359
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1010-1051 9.02e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 9.02e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 667300539  1010 GNLYWTDWNRDsPKIETSYMDGTNRRILVQDDLGLPNGLTFD 1051
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 967-1006 1.28e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.28e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 667300539   967 RNIFWTDSLLD-RIEVAKLDGSQRRVLLETDLVNPRGIVTD 1006
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 606-642 2.58e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.98  E-value: 2.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 667300539   606 CYIGTHGCDTNAACRPGPGtQFTCECSIGFRGDGRIC 642
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
644-685 4.55e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 4.55e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 667300539    644 DIDECAEqPSVCGSNAICNNHPATFRCECMEGfrFSDEGTCV 685
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPG--YTDGRNCE 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
847-1067 7.94e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.62  E-value: 7.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  847 PGMRPPCLSTVAPPIHQGPSVPTAVIPLPPGTHLLFAQTGKIEHLPLEGTTMKKTEAKALLHIPAKVIIGLAFDCVDKMV 926
Cdd:COG3391     3 VASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  927 YWTDIGEPSIGRASLHGGEPSTIVRQDlGSPEGIAVDHLGRNIFWTDSLLDRieVAKLDGSQRRVLLETDL-VNPRGIVT 1005
Cdd:COG3391    83 YVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVATIPVgAGPHGIAV 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 667300539 1006 DSVRGNLYWTDWnrDSPKIET--SYMDGTNRRILVQDDLG-LPNGLTFDTFSSQLCWVDAGTHRA 1067
Cdd:COG3391   160 DPDGKRLYVANS--GSNTVSVivSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNTS 222
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 916-945 1.38e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.06  E-value: 1.38e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 667300539    916 GLAFDCVDKMVYWTDIGEPSIGRASLHGGE 945
Cdd:smart00135   13 GLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_CA pfam07645
Calcium-binding EGF domain;
644-675 1.91e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 1.91e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 667300539   644 DIDECAEQPSVCGSNAICNNHPATFRCECMEG 675
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 644-677 2.67e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.67e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 667300539  644 DIDECAEqPSVCGSNAICNNHPATFRCECMEGFR 677
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1035-1071 7.85e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 7.85e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 667300539   1035 RILVQDDLGLPNGLTFDTFSSQLCWVDAGTHRAECLN 1071
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVAN 37
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 739-774 1.05e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 43.23  E-value: 1.05e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 667300539  739 ECQLS-RCHPDAFCYNTPGSFTCQCKPGYWGDgFRCV 774
Cdd:cd00053     1 ECAASnPCSNGGTCVNTPGSYRCVCPPGYTGD-RSCE 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 954-1108 1.71e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 47.70  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  954 LGSPEGIAVDHLGrNIFWTDSLLDRIEVAKLDGSQRRVLLET-----DLVNPRGIVTDSvRGNLYWTDWNRDSPKIETSy 1028
Cdd:cd05819    54 FNEPAGVAVDSDG-NLYVADTGNHRIQKFDPDGNFLASFGGSgdgdgEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDP- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539 1029 mDGTNRRIL-----VQDDLGLPNGLTFDtfSSQLCWV-DAGTHRAECLNPAQ------PSRRKVLEGLQYPF--AVTSYG 1094
Cdd:cd05819   131 -DGEFLTTFgsggsGPGQFNGPTGVAVD--SDGNIYVaDTGNHRIQVFDPDGnflttfGSTGTGPGQFNYPTgiAVDSDG 207

                         170
                  ....*....|....
gi 667300539 1095 kNLYYTDWQTNSVV 1108
Cdd:cd05819   208 -NIYVADSGNNRVQ 220
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 912-1051 2.99e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 47.29  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  912 KVIIGLAFDCVDKMVYWTDIGEPSI------GRASLHGGEPSTiVRQDLGSPEGIAVDHLGrNIFWTDSLLDRIEVAKLD 985
Cdd:cd14963   100 KLISPAGLAIDDGKLYVSDVKKHKVivfdleGKLLLEFGKPGS-EPGELSYPNGIAVDEDG-NIYVADSGNGRIQVFDKN 177

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 667300539  986 GS-QRRVLLETD----LVNPRGIVTDSvRGNLYWTDwnRDSPKIETSYMDGTNRRILVQ--DDLG---LPNGLTFD 1051
Cdd:cd14963   178 GKfIKELNGSPDgksgFVNPRGIAVDP-DGNLYVVD--NLSHRVYVFDEQGKELFTFGGrgKDDGqfnLPNGLFID 250
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
966-1116 4.29e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.23  E-value: 4.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  966 GRNIFWTDSLLDRIEVakLDGSQRRVLLETDL-VNPRGIVTDSVRGNLYWTDWNRDSpkieTSYMDGTNRRILVQDDLGL 1044
Cdd:COG3391    79 GRRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGR----VSVIDTATGKVVATIPVGA 152

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 667300539 1045 -PNGLTFDTFSSQLCWVDAGTHRA----ECLNPAQPSRRKVLEGLQYPF--AVTSYGKNLYYTDWQTNSVVAADLAISR 1116
Cdd:COG3391   153 gPHGIAVDPDGKRLYVANSGSNTVsvivSVIDTATGKVVATIPVGGGPVgvAVSPDGRRLYVANRGSNTSNGGSNTVSV 231
EGF_CA pfam07645
Calcium-binding EGF domain;
736-765 8.03e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 8.03e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 667300539   736 DVDECQLSR--CHPDAFCYNTPGSFTCQCKPG 765
Cdd:pfam07645    1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 923-1108 1.03e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.27  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  923 DKMVYWTDIGEPSIGRASLHGGEPSTiVRQDLGSPEGIAVDHLGRniFWTDSLLDRIEVAKLDGSQRRVLLET---DLVN 999
Cdd:COG3386    18 DGRLYWVDIPGGRIHRYDPDGGAVEV-FAEPSGRPNGLAFDPDGR--LLVADHGRGLVRFDPADGEVTVLADEygkPLNR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539 1000 PRGIVTDSvRGNLYWTD--WNRDSPKIetSYMDGTNRRILVQDDLGLPNGLTFDTFSSQLCWVDAGTH---RAECLNPAQ 1074
Cdd:COG3386    95 PNDGVVDP-DGRLYFTDmgEYLPTGAL--YRVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGriyRFDLDADGT 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 667300539 1075 PSRRKVL----EGLQYP--FAVTSYGkNLYYTDWQTNSVV 1108
Cdd:COG3386   172 LGNRRVFadlpDGPGGPdgLAVDADG-NLWVALWGGGGVV 210
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
923-1107 3.17e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 43.85  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  923 DKMVYWTDIGEPSIGRASLHGGEPSTIVRQDLGSPEGIAVDHLGrNIFWTDSLLDRIevAKLD---GSQRRVLLETDLVN 999
Cdd:COG4257    27 DGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPDG-NLWFTDNGNNRI--GRIDpktGEITTFALPGGGSN 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539 1000 PRGIVTDSvRGNLYWTDWNRDS-PKIETSymDGTNRRILVQDDLGLPNGLTFD---------TFSSQLCWVDAGT---HR 1066
Cdd:COG4257   104 PHGIAFDP-DGNLWFTDQGGNRiGRLDPA--TGEVTEFPLPTGGAGPYGIAVDpdgnlwvtdFGANAIGRIDPDTgtlTE 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 667300539 1067 AECLNPAQPSRRkvleglqypFAVTSYGkNLYYTDWQTNSV 1107
Cdd:COG4257   181 YALPTPGAGPRG---------LAVDPDG-NLWVADTGSGRI 211
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 916-1108 6.35e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.97  E-value: 6.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  916 GLAFDCVDKmVYWTDIGEPSIGRASLHGGEPSTIVRQDLGSPEGIAVDHLGrNIFWTDSLLDRieVAKL--DGSQRRVLL 993
Cdd:cd14952    14 GVAVDAAGN-VYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDAAG-TVYVTDFGNNR--VLKLaaGSTTQTVLP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  994 ETDLVNPRGIVTDSVrGNLYWTDWnrdspkietsymdgTNRRILVQ------------DDLGLPNGLTFDtfSSQLCWV- 1060
Cdd:cd14952    90 FTGLNDPTGVAVDAA-GNVYVADT--------------GNNRVLKLaagsntqtvlpfTGLSNPDGVAVD--GAGNVYVt 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 667300539 1061 DAGTHRAECLnPAQPSRRKVL--EGLQYPFAVT--SYGkNLYYTDWQTNSVV 1108
Cdd:cd14952   153 DTGNNRVLKL-AAGSTTQTVLpfTGLNSPSGVAvdTAG-NVYVTDHGNNRVL 202
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 953-1108 8.24e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.58  E-value: 8.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  953 DLGSPEGIAVDHlGRNIFWTDSLLDRieVAKLD-GSQRRVLLE-TDLVNPRGIVTDSVrGNLYWTdwnrdspkietsymD 1030
Cdd:cd14952    92 GLNDPTGVAVDA-AGNVYVADTGNNR--VLKLAaGSNTQTVLPfTGLSNPDGVAVDGA-GNVYVT--------------D 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539 1031 GTNRRIL-------VQ-----DDLGLPNGLTFDTfSSQLCWVDAGTHRAECLnPAQPSRRKVLE--GLQYP--FAVTSYG 1094
Cdd:cd14952   154 TGNNRVLklaagstTQtvlpfTGLNSPSGVAVDT-AGNVYVTDHGNNRVLKL-AAGSTTPTVLPftGLNGPlgVAVDAAG 231

                         170
                  ....*....|....
gi 667300539 1095 kNLYYTDWQTNSVV 1108
Cdd:cd14952   232 -NVYVADRGNDRVV 244
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 948-1113 2.20e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.42  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539  948 TIVRQDLGSPEGIAVDHLGRnIFWTDSLLDRIEVAKLDGSQRRVLLETD------LVNPRG--IVTDSVRGnLYWTDWNr 1019
Cdd:COG3386     1 KLADAGFRLGEGPVWDPDGR-LYWVDIPGGRIHRYDPDGGAVEVFAEPSgrpnglAFDPDGrlLVADHGRG-LVRFDPA- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667300539 1020 dspkietsymDGTNRRILVQDDLGL--PNGLTFD---TFssqlcWV-DAGTHRAE----CLNPAQpSRRKVLEGLQYP-- 1087
Cdd:COG3386    78 ----------DGEVTVLADEYGKPLnrPNDGVVDpdgRL-----YFtDMGEYLPTgalyRVDPDG-SLRVLADGLTFPng 141

                         170       180
                  ....*....|....*....|....*.
gi 667300539 1088 FAVTSYGKNLYYTDWQTNSVVAADLA 1113
Cdd:COG3386   142 IAFSPDGRTLYVADTGAGRIYRFDLD 167
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 720-739 2.21e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.62  E-value: 2.21e-03
                           10        20
                   ....*....|....*....|..
gi 667300539   720 TCSCLPGFSG--DGRACQDVDE 739
Cdd:pfam12662    1 TCSCPPGYQLdpDGRTCVDIDE 22
EGF smart00181
Epidermal growth factor-like domain;
739-774 7.49e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.19  E-value: 7.49e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 667300539    739 ECQLSR-CHPDaFCYNTPGSFTCQCKPGYWGDGfRCV 774
Cdd:smart00181    1 ECASGGpCSNG-TCINTPGSYTCSCPPGYTGDK-RCE 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
693-735 9.03e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 9.03e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 667300539    693 IDYCTTGlHDCDipQRARCVYTGGSsYTCSCLPGFSgDGRACQ 735
Cdd:smart00179    2 IDECASG-NPCQ--NGGTCVNTVGS-YRCECPPGYT-DGRNCE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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