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Conserved domains on  [gi|1938815185|ref|XP_008001255|]
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alpha-lactalbumin [Chlorocebus sabaeus]

Protein Classification

lysozyme family protein; bifunctional lytic transglycosylase/C40 family peptidase( domain architecture ID 11081454)

lysozyme family protein| bifunctional lytic transglycosylase/C40 family peptidase may catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and/or cleave peptide cross-bridges between glycan chains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 34-152 2.86e-75

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


:

Pssm-ID: 395016  Cd Length: 123  Bit Score: 220.37  E-value: 2.86e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938815185  34 KQFTKCELSQLLK--DIDGYGGIALPEFICTMFHTSGYDTQAIVESNGSTEYGLFQISNKLWCKSSQVPQSRNICDISCD 111
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1938815185 112 KFLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWL 152
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQWI 121
 
Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 34-152 2.86e-75

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 220.37  E-value: 2.86e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938815185  34 KQFTKCELSQLLK--DIDGYGGIALPEFICTMFHTSGYDTQAIVESNGSTEYGLFQISNKLWCKSSQVPQSRNICDISCD 111
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1938815185 112 KFLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWL 152
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQWI 121
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 35-153 3.06e-70

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 207.67  E-value: 3.06e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938815185  35 QFTKCELSQLLKDI--DGYGGIALPEFICTMFHTSGYDTQAIVESNGSTEYGLFQISNKLWCKSSQVPQSRNICDISCDK 112
Cdd:cd16898     2 IFTKCELSQILKEHglDGFNGISLPEWICVTFHTSGYDTQALVYNNGSTEYGLFQISNKGWCDDSQEPVSRNICGISCSK 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1938815185 113 FLDDDITDDIMCAKKILDI-KGIDYWLAHKALCTEKLEQWLC 153
Cdd:cd16898    82 LLDDDITDDIACAKKILAIpKGIDYWKAHKPFCREDLDQWRC 123
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
34-154 4.16e-69

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 204.83  E-value: 4.16e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938815185   34 KQFTKCELSQLLKD--IDGYGGIALPEFICTMFHTSGYDTQAIVESNG-STEYGLFQISNKLWCKSSQVPQSRNICDISC 110
Cdd:smart00263   1 KVFTRCELARELKRlgLDGYRGISLANWVCLAFHESGYNTQATNYNNGgSTDYGIFQINSKYWCNDGKTPGSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1938815185  111 DKFLDDDITDDIMCAKKILDIKGIDYWLAHKALC-TEKLEQWL--CE 154
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCqGEDLSQWIrgCG 127
 
Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 34-152 2.86e-75

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 220.37  E-value: 2.86e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938815185  34 KQFTKCELSQLLK--DIDGYGGIALPEFICTMFHTSGYDTQAIVESNGSTEYGLFQISNKLWCKSSQVPQSRNICDISCD 111
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1938815185 112 KFLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWL 152
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQWI 121
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 35-153 3.06e-70

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 207.67  E-value: 3.06e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938815185  35 QFTKCELSQLLKDI--DGYGGIALPEFICTMFHTSGYDTQAIVESNGSTEYGLFQISNKLWCKSSQVPQSRNICDISCDK 112
Cdd:cd16898     2 IFTKCELSQILKEHglDGFNGISLPEWICVTFHTSGYDTQALVYNNGSTEYGLFQISNKGWCDDSQEPVSRNICGISCSK 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1938815185 113 FLDDDITDDIMCAKKILDI-KGIDYWLAHKALCTEKLEQWLC 153
Cdd:cd16898    82 LLDDDITDDIACAKKILAIpKGIDYWKAHKPFCREDLDQWRC 123
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 34-152 3.79e-69

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 204.73  E-value: 3.79e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938815185  34 KQFTKCELSQLLKDIDGYGGIALPEFICTMFHTSGYDTQAIVES-NGSTEYGLFQISNKLWCKSSQVPQSRNICDISCDK 112
Cdd:cd00119     1 KVFTRCELARLLKDIGGYGGISLPNWVCLMKHESGYDTQATNENnNGSTDYGLFQINSRYWCKDGQTPGARNICDISCSK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1938815185 113 FLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWL 152
Cdd:cd00119    81 LLTDDITDAIMCAKKIVDDKGIDAWVAWKNHCQNKLRQYV 120
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
34-154 4.16e-69

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 204.83  E-value: 4.16e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938815185   34 KQFTKCELSQLLKD--IDGYGGIALPEFICTMFHTSGYDTQAIVESNG-STEYGLFQISNKLWCKSSQVPQSRNICDISC 110
Cdd:smart00263   1 KVFTRCELARELKRlgLDGYRGISLANWVCLAFHESGYNTQATNYNNGgSTDYGIFQINSKYWCNDGKTPGSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1938815185  111 DKFLDDDITDDIMCAKKILDIKGIDYWLAHKALC-TEKLEQWL--CE 154
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCqGEDLSQWIrgCG 127
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 34-153 1.11e-37

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 125.07  E-value: 1.11e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938815185  34 KQFTKCELSQLLKD--IDGYGGIALPEFICTMFHTSGYDTQAIVESN-GSTEYGLFQISNKLWCKSSQVPqSRNICDISC 110
Cdd:cd16897     1 KIFSRCELARILKRggLDGYRGYSLANWVCLAYYESGFNTRATNENPdGSTDYGIFQINSRYWCNDGKTP-SKNLCHISC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1938815185 111 DKFLDDDITDDIMCAKKIL-DIKGIDYWLAHKALCTEK-LEQWLC 153
Cdd:cd16897    80 SDLLNDDITDDIKCAKKIVkDPQGMGAWVAWRLHCEGRdLSRWLD 124
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 34-147 6.29e-32

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 110.39  E-value: 6.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938815185  34 KQFTKCELSQLLKDIdgygGIA---LPEFICTMFHTSGYDTQAIVE--SNGSTEYGLFQISNKLWCKSSQvpQSRNICDI 108
Cdd:cd16899     1 KIFTRCELARELRKL----GVPrsqLANWVCLAEHESSFNTTAVGGpnSDGSGDYGLFQINDKYWCSPGG--GSGNGCNV 74

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1938815185 109 SCDKFLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEK 147
Cdd:cd16899    75 KCEDLLDDDISDDVKCAKKIYKEQGFNAWVGWKNKCKGK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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