NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578834946|ref|XP_006723466|]
View 

optic atrophy 3 protein isoform X1 [Homo sapiens]

Protein Classification

OPA3 family protein( domain architecture ID 8515)

OPA3 family protein similar to human optic atrophy 3 protein (OPA3) that may play some role in mitochondrial processes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
OPA3 super family cl06196
Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) ...
 1-73 8.52e-10

Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.


The actual alignment was detected with superfamily member pfam07047:

Pssm-ID: 462072 [Multi-domain]  Cd Length: 122  Bit Score: 52.51  E-value: 8.52e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578834946    1 MRTKMRIMGF--RGTVIKPLNEEAAAELGAELLGEATIFIVGGGCLVLEYWRHQAQQRHKEEEQRAAWNALRDEV 73
Cdd:pfam07047  45 MRLRMRLLGLakPTRKIRPLNEEKAVELGADLLGEAFIFSVAGGLILYEYWRSARKEAKKEEKLKEELEELEERI 119
 
Name Accession Description Interval E-value
OPA3 pfam07047
Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) ...
 1-73 8.52e-10

Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.


Pssm-ID: 462072 [Multi-domain]  Cd Length: 122  Bit Score: 52.51  E-value: 8.52e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578834946    1 MRTKMRIMGF--RGTVIKPLNEEAAAELGAELLGEATIFIVGGGCLVLEYWRHQAQQRHKEEEQRAAWNALRDEV 73
Cdd:pfam07047  45 MRLRMRLLGLakPTRKIRPLNEEKAVELGADLLGEAFIFSVAGGLILYEYWRSARKEAKKEEKLKEELEELEERI 119
 
Name Accession Description Interval E-value
OPA3 pfam07047
Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) ...
 1-73 8.52e-10

Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.


Pssm-ID: 462072 [Multi-domain]  Cd Length: 122  Bit Score: 52.51  E-value: 8.52e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578834946    1 MRTKMRIMGF--RGTVIKPLNEEAAAELGAELLGEATIFIVGGGCLVLEYWRHQAQQRHKEEEQRAAWNALRDEV 73
Cdd:pfam07047  45 MRLRMRLLGLakPTRKIRPLNEEKAVELGADLLGEAFIFSVAGGLILYEYWRSARKEAKKEEKLKEELEELEERI 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH