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Conserved domains on  [gi|578815470|ref|XP_006716453|]
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sodium-dependent phosphate transporter 2 isoform X2 [Homo sapiens]

Protein Classification

inorganic phosphate transporter( domain architecture ID 10475700)

inorganic phosphate transporter is involved in phosphate transport, such as bacterial low-affinity inorganic phosphate transporter and vertebrate sodium-dependent phosphate transporters, which play fundamental housekeeping roles in phosphate transport

Gene Ontology:  GO:0005315|GO:0006817|GO:0016020
TCDB:  2.A.20

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
439-590 5.94e-73

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


:

Pssm-ID: 460184  Cd Length: 322  Bit Score: 236.63  E-value: 5.94e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470  439 LFHFLQVLTACFGSFAHGGNDVSNAIGPLV-ALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLT 517
Cdd:pfam01384 170 LFRFLQILSAALVSFAHGANDVQNAMGPLTaALYAIGTTGEVASKAPVPLWVLLLGALAIALGTWTGGWRIIKTVGNKIT 249
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578815470  518 PITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFS 590
Cdd:pfam01384 250 KLTPSRGFAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGLARGLSAVNWGVVGNIVLAWVLTLPVAALLS 322
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
25-177 2.83e-30

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


:

Pssm-ID: 460184  Cd Length: 322  Bit Score: 121.07  E-value: 2.83e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470   25 GANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLyneTVETLMAGEVSAM--------- 95
Cdd:pfam01384   1 GANDVANAFATSVGSRALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSF---DPGVLMLGMLAALlgaaiwlli 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470   96 --------------------------------------VVASWFISPLLSGFMSGLLFVLIRIFILKKEDP--------- 128
Cdd:pfam01384  78 atylglpvssthalvgaligaglaaagfdavnwgglgkIVASWVISPLLGGIIAALLFLLIRRLILRRKNPlkalrllpg 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578815470  129 ---------VPNGLRALPVFYAATIAIN----------------VFSIMYTGAPVLGLVLPMWAIALISFGVAL 177
Cdd:pfam01384 158 lirakydnkVERLFRFLQILSAALVSFAhgandvqnamgpltaaLYAIGTTGEVASKAPVPLWVLLLGALAIAL 231
 
Name Accession Description Interval E-value
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
439-590 5.94e-73

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 236.63  E-value: 5.94e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470  439 LFHFLQVLTACFGSFAHGGNDVSNAIGPLV-ALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLT 517
Cdd:pfam01384 170 LFRFLQILSAALVSFAHGANDVQNAMGPLTaALYAIGTTGEVASKAPVPLWVLLLGALAIALGTWTGGWRIIKTVGNKIT 249
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578815470  518 PITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFS 590
Cdd:pfam01384 250 KLTPSRGFAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGLARGLSAVNWGVVGNIVLAWVLTLPVAALLS 322
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
436-598 1.27e-46

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 166.88  E-value: 1.27e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470 436 VHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIykqGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKD 515
Cdd:COG0306  168 VNRGFRRLQIVSAALMAFSHGANDAQKAMGIITLALLA---AGLLSGFEVPLWVILLCALAIALGTLLGGWRIIKTLGKK 244
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470 516 LTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMA 595
Cdd:COG0306  245 ITKLDPLQGFAAETSSAATVLLASLLGIPVSTTHVITGSIMGVGAARRLSAVRWGVAGRIVLAWVLTLPAAALLAALLYL 324

                 ...
gi 578815470 596 LLM 598
Cdd:COG0306  325 LLS 327
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
25-177 2.83e-30

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 121.07  E-value: 2.83e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470   25 GANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLyneTVETLMAGEVSAM--------- 95
Cdd:pfam01384   1 GANDVANAFATSVGSRALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSF---DPGVLMLGMLAALlgaaiwlli 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470   96 --------------------------------------VVASWFISPLLSGFMSGLLFVLIRIFILKKEDP--------- 128
Cdd:pfam01384  78 atylglpvssthalvgaligaglaaagfdavnwgglgkIVASWVISPLLGGIIAALLFLLIRRLILRRKNPlkalrllpg 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578815470  129 ---------VPNGLRALPVFYAATIAIN----------------VFSIMYTGAPVLGLVLPMWAIALISFGVAL 177
Cdd:pfam01384 158 lirakydnkVERLFRFLQILSAALVSFAhgandvqnamgpltaaLYAIGTTGEVASKAPVPLWVLLLGALAIAL 231
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
7-177 5.62e-22

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 97.16  E-value: 5.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470   7 LWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYneTVET 86
Cdd:COG0306    4 LLLLIVVILLALFFDFNNGFHDAANAIATAVGTRALSPRTAVLLAAVFNFLGALLFGTAVAKTIGKGIVDPGIL--TLEV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470  87 LMAGEVSAM-------------------------------------------VVASWFISPLLSGFMSGLLFVLIR-IFI 122
Cdd:COG0306   82 VLAALLGAIlwnlitwylgipsssshalvgglvgaglaaagfgavnwgvllkIVLPWVLSPLIGFLLGFLLMRLLYwLFR 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578815470 123 LKKEDPVPNGLRALPVFYAATIAIN------------VFSIMYTGAPVLGLVLPMWAIALISFGVAL 177
Cdd:COG0306  162 RANPRRVNRGFRRLQIVSAALMAFShgandaqkamgiITLALLAAGLLSGFEVPLWVILLCALAIAL 228
 
Name Accession Description Interval E-value
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
439-590 5.94e-73

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 236.63  E-value: 5.94e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470  439 LFHFLQVLTACFGSFAHGGNDVSNAIGPLV-ALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLT 517
Cdd:pfam01384 170 LFRFLQILSAALVSFAHGANDVQNAMGPLTaALYAIGTTGEVASKAPVPLWVLLLGALAIALGTWTGGWRIIKTVGNKIT 249
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578815470  518 PITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFS 590
Cdd:pfam01384 250 KLTPSRGFAAELAAAITVLLASRLGLPVSTTHVIVGAIVGVGLARGLSAVNWGVVGNIVLAWVLTLPVAALLS 322
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
436-598 1.27e-46

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 166.88  E-value: 1.27e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470 436 VHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIykqGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKD 515
Cdd:COG0306  168 VNRGFRRLQIVSAALMAFSHGANDAQKAMGIITLALLA---AGLLSGFEVPLWVILLCALAIALGTLLGGWRIIKTLGKK 244
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470 516 LTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMA 595
Cdd:COG0306  245 ITKLDPLQGFAAETSSAATVLLASLLGIPVSTTHVITGSIMGVGAARRLSAVRWGVAGRIVLAWVLTLPAAALLAALLYL 324

                 ...
gi 578815470 596 LLM 598
Cdd:COG0306  325 LLS 327
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
25-177 2.83e-30

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 121.07  E-value: 2.83e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470   25 GANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLyneTVETLMAGEVSAM--------- 95
Cdd:pfam01384   1 GANDVANAFATSVGSRALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSF---DPGVLMLGMLAALlgaaiwlli 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470   96 --------------------------------------VVASWFISPLLSGFMSGLLFVLIRIFILKKEDP--------- 128
Cdd:pfam01384  78 atylglpvssthalvgaligaglaaagfdavnwgglgkIVASWVISPLLGGIIAALLFLLIRRLILRRKNPlkalrllpg 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578815470  129 ---------VPNGLRALPVFYAATIAIN----------------VFSIMYTGAPVLGLVLPMWAIALISFGVAL 177
Cdd:pfam01384 158 lirakydnkVERLFRFLQILSAALVSFAhgandvqnamgpltaaLYAIGTTGEVASKAPVPLWVLLLGALAIAL 231
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
7-177 5.62e-22

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 97.16  E-value: 5.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470   7 LWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYneTVET 86
Cdd:COG0306    4 LLLLIVVILLALFFDFNNGFHDAANAIATAVGTRALSPRTAVLLAAVFNFLGALLFGTAVAKTIGKGIVDPGIL--TLEV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470  87 LMAGEVSAM-------------------------------------------VVASWFISPLLSGFMSGLLFVLIR-IFI 122
Cdd:COG0306   82 VLAALLGAIlwnlitwylgipsssshalvgglvgaglaaagfgavnwgvllkIVLPWVLSPLIGFLLGFLLMRLLYwLFR 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578815470 123 LKKEDPVPNGLRALPVFYAATIAIN------------VFSIMYTGAPVLGLVLPMWAIALISFGVAL 177
Cdd:COG0306  162 RANPRRVNRGFRRLQIVSAALMAFShgandaqkamgiITLALLAAGLLSGFEVPLWVILLCALAIAL 228
PHO4 pfam01384
Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is ...
456-602 1.37e-15

Phosphate transporter family; This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.


Pssm-ID: 460184  Cd Length: 322  Bit Score: 77.92  E-value: 1.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470  456 GGNDVSNAIGPLVAlwliykqggvTQeAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIE------L 529
Cdd:pfam01384   1 GANDVANAFATSVG----------SR-ALTPRQAVILAAIFEFLGAVLLGARVAETIGKGIVDVSFDPGVLMLgmlaalL 69
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578815470  530 ASAFTVVIASNIGLPVSTTHCKVGSVVAVGW-IRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGIL 602
Cdd:pfam01384  70 GAAIWLLIATYLGLPVSSTHALVGALIGAGLaAAGFDAVNWGGLGKIVASWVISPLLGGIIAALLFLLIRRLIL 143
PitA COG0306
Phosphate/sulfate permease [Inorganic ion transport and metabolism];
445-599 2.94e-13

Phosphate/sulfate permease [Inorganic ion transport and metabolism];


Pssm-ID: 440075  Cd Length: 330  Bit Score: 70.97  E-value: 2.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578815470 445 VLTACFGSFAHGGNDVSNAIGPLVAlwliykqggvTQeAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTP---ITP 521
Cdd:COG0306   11 ILLALFFDFNNGFHDAANAIATAVG----------TR-ALSPRTAVLLAAVFNFLGALLFGTAVAKTIGKGIVDpgiLTL 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578815470 522 SSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGW-IRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMY 599
Cdd:COG0306   80 EVVLAALLGAILWNLITWYLGIPSSSSHALVGGLVGAGLaAAGFGAVNWGVLLKIVLPWVLSPLIGFLLGFLLMRLLYW 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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