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Conserved domains on  [gi|571451607|ref|XP_006578788|]
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probable gamma-secretase subunit PEN-2 isoform X1 [Glycine max]

Protein Classification

PEN-2 domain-containing protein( domain architecture ID 10563016)

PEN-2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEN-2 pfam10251
Presenilin enhancer-2 subunit of gamma secretase; This entry is a short 101 peptide protein ...
 51-140 3.87e-36

Presenilin enhancer-2 subunit of gamma secretase; This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex.


:

Pssm-ID: 463024  Cd Length: 93  Bit Score: 120.02  E-value: 3.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571451607   51 SEEESVGYARRFYTFGFALLPLLWAVNCFYFWPVLRHSHSF---PRIRPYVVGSAIGFAVCATLLSSWSLTFAIGGErLF 127
Cdd:pfam10251   1 SNEEKLNLCRKYFLAGFALLPFLWLVNAVWFFPEAFRKPPFeeqPQIRKYVIRSAIGFLVWSVLLITWIIIFQINRA-LW 79

                          90
                  ....*....|....
gi 571451607  128 GPVWDQL-VMYNLA 140
Cdd:pfam10251  80 GAFGDYLsFIIPLG 93
 
Name Accession Description Interval E-value
PEN-2 pfam10251
Presenilin enhancer-2 subunit of gamma secretase; This entry is a short 101 peptide protein ...
 51-140 3.87e-36

Presenilin enhancer-2 subunit of gamma secretase; This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex.


Pssm-ID: 463024  Cd Length: 93  Bit Score: 120.02  E-value: 3.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571451607   51 SEEESVGYARRFYTFGFALLPLLWAVNCFYFWPVLRHSHSF---PRIRPYVVGSAIGFAVCATLLSSWSLTFAIGGErLF 127
Cdd:pfam10251   1 SNEEKLNLCRKYFLAGFALLPFLWLVNAVWFFPEAFRKPPFeeqPQIRKYVIRSAIGFLVWSVLLITWIIIFQINRA-LW 79

                          90
                  ....*....|....
gi 571451607  128 GPVWDQL-VMYNLA 140
Cdd:pfam10251  80 GAFGDYLsFIIPLG 93
 
Name Accession Description Interval E-value
PEN-2 pfam10251
Presenilin enhancer-2 subunit of gamma secretase; This entry is a short 101 peptide protein ...
 51-140 3.87e-36

Presenilin enhancer-2 subunit of gamma secretase; This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex.


Pssm-ID: 463024  Cd Length: 93  Bit Score: 120.02  E-value: 3.87e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571451607   51 SEEESVGYARRFYTFGFALLPLLWAVNCFYFWPVLRHSHSF---PRIRPYVVGSAIGFAVCATLLSSWSLTFAIGGErLF 127
Cdd:pfam10251   1 SNEEKLNLCRKYFLAGFALLPFLWLVNAVWFFPEAFRKPPFeeqPQIRKYVIRSAIGFLVWSVLLITWIIIFQINRA-LW 79

                          90
                  ....*....|....
gi 571451607  128 GPVWDQL-VMYNLA 140
Cdd:pfam10251  80 GAFGDYLsFIIPLG 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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