N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136  46 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 125
Cdd:cd07886    1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136 126 DGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRM 205
Cdd:cd07886   81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                        170
                 ....*....|..
gi 568945136 206 DPILSEPVYDKK 217
Cdd:cd07886  161 SPVLSEPIYDKK 172

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136  225 RICRINKESGPCTGGEELYLLCDKVQKEDISVVFS-----TASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTVN 299
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDDIKVRFYeeddgQEVWEAEGDFSKTDVHRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|..
gi 568945136  300 VFLQRLTDGVCSEPLPFTYLPR 321
Cdd:pfam16179  81 IQLRRPSDKATSEPQPFTYLPL 102

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136  46 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 125
Cdd:cd07886    1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136 126 DGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRM 205
Cdd:cd07886   81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                        170
                 ....*....|..
gi 568945136 206 DPILSEPVYDKK 217
Cdd:cd07886  161 SPVLSEPIYDKK 172

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136   48 LVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLVWKDWPHRVHPHSLVGKDCTDG 127
Cdd:pfam00554   1 LEIVEQPKQRGMRFRYKCEGRSAGSIPGESSTRSKKTFPTVQICNYDG--PAVIRVSLVTKDEPHRPHPHSLVGKDCKDG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136  128 VCRVRLRPHvSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYN--AGSLKNHQEVDMNVVRICFQASYRDQQG-HLHR 204
Cdd:pfam00554  79 VCEVELGPE-DMVASFQNLGIQCVKKKDVEEALKERIELNIDPFNvgFEALRQIKDMDLNVVRLCFQAFLPDTRGnFTTP 157

                         170
                  ....*....|..
gi 568945136  205 MDPILSEPVYDK 216
Cdd:pfam00554 158 LPPVVSNPIYDK 169

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136 224 LRICRINKESGPCTGGEELYLLCDKVQKEDISVVF-----STASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTV 298
Cdd:cd01177    1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFfeedeEETVWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                         90       100
                 ....*....|....*....|..
gi 568945136 299 NVFLQRLTDGVCSEPLPFTYLP 320
Cdd:cd01177   81 KIQLKRPSDGERSESVPFTYVP 102

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136  46 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 125
Cdd:cd07886    1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136 126 DGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRM 205
Cdd:cd07886   81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                        170
                 ....*....|..
gi 568945136 206 DPILSEPVYDKK 217
Cdd:cd07886  161 SPVLSEPIYDKK 172

RelB transactivation domain; This domain is the transactivation domain of the transcription factor RelB.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136  324 DSYGVDKKRKRGLPDVLGELSSSD-PHGIESKRRKKKPVFLDHFLPGHSSGL-FLPPSALQPaDSDFFPASISLPGLEPP 401
Cdd:pfam16181   1 DSYGVDKKRKRGMPDVLGELNSSDpPHAIESKRPKKKLSSLDHFLPSHSAALaFLPPAALLA-DPDFFLGPVSLPGLEPP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136  402 GGPDLLDD-GFAYDPSAPTLFTMLDLLPPAPPLASAVVGSGGAGATVVESSGPEPLSLDSFAAPGPGDVGTASLVGSNMF 480
Cdd:pfam16181  80 GAPDLLDDyGFAYDPSAHFFFTMLDLFPGPGPLASAVPGAGAAGEAPGEPHGPELLSLDSYAAPASADEATASLVGSNMF 159

                         170       180
                  ....*....|....*....|..
gi 568945136  481 PNQYREAAFGG-GLLSPGPEAT 501
Cdd:pfam16181 160 PNQYREAAFGGsGLLPPGPEAT 181

N-terminal sub-domain of the Rel homology domain (RHD) of RelA; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD domain of the RelA family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelA (also called p65) forms heterodimers with NF-kappa B1 (p50) and B2 (p52). RelA also forms homodimers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136  46 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCT 125
Cdd:cd07885    1 PYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINNYTGPGRVRIS--LVTKDPPHKPHPHELVGKDCK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136 126 DGVCRVRLRPHVSPrHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRM 205
Cdd:cd07885   79 DGYYEAELSPDRCI-HSFQNLGIQCVKKRDLEQAVSQRIQTNNNPFNVPIEEQRADYDLNAVRLCFQVTVRDPSGRLLPL 157

                        170
                 ....*....|..
gi 568945136 206 DPILSEPVYDKK 217
Cdd:cd07885  158 PPVLSQPIYDNR 169

N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the c-Rel family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). c-Rel plays an important role in B cell proliferation and survival.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136  46 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCT 125
Cdd:cd07933    1 PYVEIFEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQILNYTGKGKVRIT--LVTKNEPYKPHPHDLVGKDCR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136 126 DGVCRVRLRPHVSPRhSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAG--SLKNHQEVDMNVVRICFQASYRDQQGHLH 203
Cdd:cd07933   79 DGYYEAEFGPERRVL-AFQNLGIQCVRRREVKEAIMLRISRGINPFNVPeeQLLQIEEYDLNVVRLCFQIFLPDEHGNYT 157

                        170
                 ....*....|....*
gi 568945136 204 RM-DPILSEPVYDKK 217
Cdd:cd07933  158 TAlPPIVSNPIYDNR 172

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136 224 LRICRINKESGPCTGGEELYLLCDKVQKEDISVVF-----STASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTV 298
Cdd:cd01177    1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFfeedeEETVWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                         90       100
                 ....*....|....*....|..
gi 568945136 299 NVFLQRLTDGVCSEPLPFTYLP 320
Cdd:cd01177   81 KIQLKRPSDGERSESVPFTYVP 102

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136 224 LRICRINKESGPCTGGEELYLLCDKVQKEDISVVF-----STASWEGRADFSQADVHrQIAIVFKTPPYEDLEISEPVTV 298
Cdd:cd00602    1 LPICRVSSLSGSVNGGDEVFLLCDKVNKPDIKVWFgekgpGETVWEAEAMFRQEDVR-QVAIVFKTPPYHNKWITRPVQV 79

                         90       100
                 ....*....|....*....|..
gi 568945136 299 NVFLQRLTDGVCSEPLPFTYLP 320
Cdd:cd00602   80 PIQLVRPDDRKRSEPLTFTYTP 101

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B1 family of transcription factors, a class I member of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. NF-kappa B1 is commonly referred to as p105 or p50 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). NF-kappa B1 is involved in the canonical NF-kappa B signaling pathway which is activated by many agonists and is essential in immune and inflammatory responses, as well as cell survival. p105 is involved in its own specific NF-kappa B signaling pathway which is also implicated in immune and inflammatory responses. p105 may also act as an I-kappa B due to its C-terminal ankyrin repeats. It is also involved in mitogen-activated protein kinase (MAPK) signaling as its degradation leads to the activation of TPL-2, a MAPK kinase kinase which activates ERK pathways.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136  46 PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELrdCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 125
Cdd:cd07935    1 PYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKI--CNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136 126 DGVCRVRLRPHVSpRHSFNNLGIQCVRKKEIEAAIE-RKIQLGIDPYNAG------------------SLKNHQ------ 180
Cdd:cd07935   79 DGICTVTAGPKDM-VVGFANLGILHVTKKKVFETLEaRMTEACKKGYNPGllvhpelaylqaegggdrQLTEREkeiirq 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568945136 181 -------EVDMNVVRICFQASYRDQQGHL-HRMDPILSEPVYDKK 217
Cdd:cd07935  158 aavqqtkEMDLSVVRLMFTAFLPDSTGGFtRRLEPVVSDAIYDSK 202

ig-like, plexins, transcription factors;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136   223 ELRICRINKESGPCTGGEELyLLCDKVQKEDISVVFSTASWEGRADFSQAdvhRQIAIVFKTPPYEDLEISEPVTvNVFL 302
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEI-TLCGKNLKSISVVFVEVGVGEAPCTFSPS---SSTAIVCKTPPYHNIPGSVPVR-TVGL 75

                           90
                   ....*....|....*..
gi 568945136   303 QRltDGVCSEPLPFTYL 319
Cdd:smart00429  76 RN--GGVPSSPQPFTYV 90

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945136 226 ICRINKESGPCTGGEELYLLCDKVQKeDISVVF------STASWEGRADFSQADVHrQIAIVFKTPPYEDLEISEPVTVN 299
Cdd:cd01178    4 IEKKSLNSCSVNGGEELFLTGKNFLK-DSKVVFqekgqdGEAQWEAEATIDKEKSH-QNHLVVEVPPYHNKHVAAPVQVQ 81

                         90       100
                 ....*....|....*....|....*..
gi 568945136 300 VFlqrltdgVC------SEPLPFTYLP 320
Cdd:cd01178   82 FY-------VVngkrkrSQPQTFTYTP 101