Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568927149 184 CGIPPEVPEGYVVGSYSS-TLGGQAHYSCKEGFlSVSGDRISRCTALGVWEPPKLHCQ 240
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGY-TLVGSSTITCTENGGWSPPPPTCE 57

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568927149 244 CGSPPEIQNAILVGNHSS-RQGSVAHYDCQEGFEsPGGKITSVCTEKGAWSEITYAC 299
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYT-LVGSSTITCTENGGWSPPPPTC 56

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 568927149 130 DIDECEDSGLCRHGGRCVNTPGSFACYCMEGYVAKN 165
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568927149    78 DKDECQFGAtvICGNHTSCHNTPGGFYCICHEGYRATNN 116
Cdd:smart00179   1 DIDECASGN--PCQNGGTCVNTVGSYRCECPPGYTDGRN 37

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568927149 244 CGSPPEIQNAILVGNHSS-RQGSVAHYDCQEGFEsPGGKITSVCTEKGAWSEITYAC 299
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYT-LVGSSTITCTENGGWSPPPPTC 56

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                          10        20
                  ....*....|....*....|....*...
gi 568927149   47 CHEHATCQQKEGKRICICNYGFWGNGRT 74
Cdd:pfam12947   8 CHPNATCTNTGGSFTCTCNDGYTGDGVT 35

secreted complement-binding protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927149 157 CMEGYvAKNGPEPFHPRTDAT------SCTEIDCGIPPEVPEGYV-VGSYSstLGGQAHYSCKEGFLSVsGDRISRC--- 226
Cdd:PHA02927  54 CLPGY-RKQKMGPIYAKCTGTgwtlfnQCIKRRCPSPRDIDNGQLdIGGVD--FGSSITYSCNSGYQLI-GESKSYCelg 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568927149 227 -TALGVWEPPKLHCQEISCGSPPEIQNailvGNHSSRQ-----GSVAHYDCQEGFESPGGkiTSVCTEKGAWSE 294
Cdd:PHA02927 130 sTGSMVWNPEAPICESVKCQSPPSISN----GRHNGYEdfytdGSVVTYSCNSGYSLIGN--SGVLCSGGEWSD 197

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|..
gi 568927149  130 DIDECEDSG-LCRHGGRCVNTPGSFACYCMEG 160
Cdd:pfam07645   1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32

Sushi repeat (SCR repeat);

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568927149  244 CGSPPEIQNAILVGNHSSRQ-GSVAHYDCQEGFESPGGkITSVCTEKGAWS 293
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNyGASVSYECDPGYRLVGS-PTITCQEDGTWS 50

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 568927149 130 DIDECEDSGLCRHGGRCVNTPGSFACYCMEGYVAKN 165
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568927149    78 DKDECQFGAtvICGNHTSCHNTPGGFYCICHEGYRATNN 116
Cdd:smart00179   1 DIDECASGN--PCQNGGTCVNTVGSYRCECPPGYTDGRN 37

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568927149 244 CGSPPEIQNAILVGNHSS-RQGSVAHYDCQEGFEsPGGKITSVCTEKGAWSEITYAC 299
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYT-LVGSSTITCTENGGWSPPPPTC 56

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                         10        20
                 ....*....|....*....|....*....
gi 568927149 133 ECEDSGLCRHGGRCVNTPGSFACYCMEGY 161
Cdd:cd00053    1 ECAASNPCSNGGTCVNTPGSYRCVCPPGY 29

Sushi repeat (SCR repeat);

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568927149  184 CGIPPEVPEGYVVGSYSSTL-GGQAHYSCKEGFlSVSGDRISRCTALGVWEPPKLHC 239
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNyGASVSYECDPGY-RLVGSPTITCQEDGTWSPPFPEC 56

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568927149   244 CGSPPEIQNA-ILVGNHSSRQGSVAHYDCQEGFESPGGKiTSVCTEKGAWSEITYAC 299
Cdd:smart00032   1 CPPPPDIENGtVTSSSGTYSYGDTVTYSCDPGYTLIGSS-TITCLENGTWSPPPPTC 56

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568927149   78 DKDECQFGATViCGNHTSCHNTPGGFYCICHEG 110
Cdd:pfam07645   1 DVDECATGTHN-CPANTVCVNTIGSFECRCPDG 32

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                         10        20        30
                 ....*....|....*....|....*....|..
gi 568927149  81 ECQfgATVICGNHTSCHNTPGGFYCICHEGYR 112
Cdd:cd00053    1 ECA--ASNPCSNGGTCVNTPGSYRCVCPPGYT 30

Sushi repeat (SCR repeat);

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568927149  244 CGSPPEIQNAILVGNHSSRQ-GSVAHYDCQEGFESPGGkITSVCTEKGAWS 293
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNyGASVSYECDPGYRLVGS-PTITCQEDGTWS 50

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                          10        20
                  ....*....|....*....|..
gi 568927149  140 CRHGGRCVNTPGSFACYCMEGY 161
Cdd:pfam00008   6 CSNGGTCVDTPGGYTCICPEGY 27