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Conserved domains on  [gi|568971456|ref|XP_006532190|]
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granulocyte-macrophage colony-stimulating factor isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CSF2 super family cl23816
Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of ...
 19-90 2.50e-44

Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine receptor family, mainly the GM-CSF receptor.


The actual alignment was detected with superfamily member cd00040:

Pssm-ID: 304973  Cd Length: 121  Bit Score: 139.16  E-value: 2.50e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568971456  19 KKLTCVQTRLKIFEQGLRGNFTKLKGALNMTASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFEC 90
Cdd:cd00040   50 QEPTCLQTRLKLYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCETQIITFKSFKENLKDFLFDIPFDC 121
 
Name Accession Description Interval E-value
CSF2 cd00040
Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of ...
 19-90 2.50e-44

Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine receptor family, mainly the GM-CSF receptor.


Pssm-ID: 238000  Cd Length: 121  Bit Score: 139.16  E-value: 2.50e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568971456  19 KKLTCVQTRLKIFEQGLRGNFTKLKGALNMTASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFEC 90
Cdd:cd00040   50 QEPTCLQTRLKLYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCETQIITFKSFKENLKDFLFDIPFDC 121
CSF2 smart00040
Granulocyte-macrophage colony-simulating factor (GM-CSF); GM-CSF stimulates the development of ...
 19-90 2.53e-44

Granulocyte-macrophage colony-simulating factor (GM-CSF); GM-CSF stimulates the development of and the cytotoxic activity of white blood cells.


Pssm-ID: 128355  Cd Length: 121  Bit Score: 139.19  E-value: 2.53e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568971456    19 KKLTCVQTRLKIFEQGLRGNFTKLKGALNMTASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFEC 90
Cdd:smart00040  50 QEPTCLQTRLKLYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCETQIITFKSFKENLKDFLFDIPFDC 121
GM_CSF pfam01109
Granulocyte-macrophage colony-stimulating factor;
19-91 1.01e-43

Granulocyte-macrophage colony-stimulating factor;


Pssm-ID: 144630  Cd Length: 122  Bit Score: 137.67  E-value: 1.01e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568971456   19 KKLTCVQTRLKIFEQGLRGNFTKLKGALNMTASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFECK 91
Cdd:pfam01109  50 QEPTCLQTRLKLYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCETQVITFKSFKENLKDFLFDIPFDCW 122
 
Name Accession Description Interval E-value
CSF2 cd00040
Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of ...
 19-90 2.50e-44

Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine receptor family, mainly the GM-CSF receptor.


Pssm-ID: 238000  Cd Length: 121  Bit Score: 139.16  E-value: 2.50e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568971456  19 KKLTCVQTRLKIFEQGLRGNFTKLKGALNMTASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFEC 90
Cdd:cd00040   50 QEPTCLQTRLKLYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCETQIITFKSFKENLKDFLFDIPFDC 121
CSF2 smart00040
Granulocyte-macrophage colony-simulating factor (GM-CSF); GM-CSF stimulates the development of ...
 19-90 2.53e-44

Granulocyte-macrophage colony-simulating factor (GM-CSF); GM-CSF stimulates the development of and the cytotoxic activity of white blood cells.


Pssm-ID: 128355  Cd Length: 121  Bit Score: 139.19  E-value: 2.53e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568971456    19 KKLTCVQTRLKIFEQGLRGNFTKLKGALNMTASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFEC 90
Cdd:smart00040  50 QEPTCLQTRLKLYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCETQIITFKSFKENLKDFLFDIPFDC 121
GM_CSF pfam01109
Granulocyte-macrophage colony-stimulating factor;
19-91 1.01e-43

Granulocyte-macrophage colony-stimulating factor;


Pssm-ID: 144630  Cd Length: 122  Bit Score: 137.67  E-value: 1.01e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568971456   19 KKLTCVQTRLKIFEQGLRGNFTKLKGALNMTASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFECK 91
Cdd:pfam01109  50 QEPTCLQTRLKLYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCETQVITFKSFKENLKDFLFDIPFDCW 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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