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Conserved domains on  [gi|568957273|ref|XP_006531290|]
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zinc finger protein 276 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein; C2H2-type zinc finger protein; zf-AD domain-containing protein; zinc-finger associated domain-containing protein; C2H2-type zinc finger protein; zf-AD domain-containing protein; zinc-finger associated domain-containing protein; C2H2-type zinc finger protein; zinc-finger associated domain-containing protein( domain architecture ID 12083238)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens DNA-binding protein Ikaros, a transcription regulator of hematopoietic cell differentiation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens DNA-binding protein Ikaros, a transcription regulator of hematopoietic cell differentiation; zf-AD domain-containing protein; zinc-finger associated domain (ZAD)-containing protein similar to Drosophila melanogaster CG2712 protein; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens DNA-binding protein Ikaros, a transcription regulator of hematopoietic cell differentiation; zf-AD domain-containing protein; zinc-finger associated domain (ZAD)-containing protein similar to Drosophila melanogaster CG2712 protein; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens DNA-binding protein Ikaros, a transcription regulator of hematopoietic cell differentiation; zinc-finger associated domain (ZAD)-containing protein similar to Drosophila melanogaster CG2712 protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 79-156 1.14e-06

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 462262  Cd Length: 75  Bit Score: 46.68  E-value: 1.14e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568957273   79 HCRLCHgkFSSRSLRSISDrvpgetserLSPGERVFIRDFQRLLGVAVHQDPALPQSVCKNCYTQFYQCHSLLRTFLQ 156
Cdd:pfam07776   1 VCRLCL--DESDELIPIFD---------PSDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLE 67
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 321-476 1.31e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957273 321 LGPCTQPHL----APSEAPGQLGETQVPSSTSDDRVKDEFSDLSEGDFLSEDESDKKQTPQSSDESfepypekkvSGKKS 396
Cdd:COG5189  258 LGPSNEEMLykyiSPSQGSAELFEESSLGFDYEFIHKSVGNKEIRGGISTGEMIDVRKLPCTNSSS---------NGKLA 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957273 397 EGREAKRPEEPKIRKKPGPKPgwkkklrcereelptiYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVF 476
Cdd:COG5189  329 HGGERNIDTPSRMLKVKDGKP----------------YKCPVEGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEKMNIF 392
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 79-156 1.14e-06

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 46.68  E-value: 1.14e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568957273   79 HCRLCHgkFSSRSLRSISDrvpgetserLSPGERVFIRDFQRLLGVAVHQDPALPQSVCKNCYTQFYQCHSLLRTFLQ 156
Cdd:pfam07776   1 VCRLCL--DESDELIPIFD---------PSDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLE 67
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 80-156 1.12e-05

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 43.66  E-value: 1.12e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568957273    80 CRLCHGkfSSRSLRSISDRvpgetserlsPGERVFIRDFQRLLGVAVHQDPALPQSVCKNCYTQFYQCHSLLRTFLQ 156
Cdd:smart00868   2 CRLCLS--ESENLVSIFDE----------SSEASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRE 66
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 321-476 1.31e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957273 321 LGPCTQPHL----APSEAPGQLGETQVPSSTSDDRVKDEFSDLSEGDFLSEDESDKKQTPQSSDESfepypekkvSGKKS 396
Cdd:COG5189  258 LGPSNEEMLykyiSPSQGSAELFEESSLGFDYEFIHKSVGNKEIRGGISTGEMIDVRKLPCTNSSS---------NGKLA 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957273 397 EGREAKRPEEPKIRKKPGPKPgwkkklrcereelptiYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVF 476
Cdd:COG5189  329 HGGERNIDTPSRMLKVKDGKP----------------YKCPVEGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEKMNIF 392
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 79-156 1.14e-06

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 46.68  E-value: 1.14e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568957273   79 HCRLCHgkFSSRSLRSISDrvpgetserLSPGERVFIRDFQRLLGVAVHQDPALPQSVCKNCYTQFYQCHSLLRTFLQ 156
Cdd:pfam07776   1 VCRLCL--DESDELIPIFD---------PSDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLE 67
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 80-156 1.12e-05

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 43.66  E-value: 1.12e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568957273    80 CRLCHGkfSSRSLRSISDRvpgetserlsPGERVFIRDFQRLLGVAVHQDPALPQSVCKNCYTQFYQCHSLLRTFLQ 156
Cdd:smart00868   2 CRLCLS--ESENLVSIFDE----------SSEASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRE 66
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 321-476 1.31e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957273 321 LGPCTQPHL----APSEAPGQLGETQVPSSTSDDRVKDEFSDLSEGDFLSEDESDKKQTPQSSDESfepypekkvSGKKS 396
Cdd:COG5189  258 LGPSNEEMLykyiSPSQGSAELFEESSLGFDYEFIHKSVGNKEIRGGISTGEMIDVRKLPCTNSSS---------NGKLA 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957273 397 EGREAKRPEEPKIRKKPGPKPgwkkklrcereelptiYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVF 476
Cdd:COG5189  329 HGGERNIDTPSRMLKVKDGKP----------------YKCPVEGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEKMNIF 392
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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