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Conserved domains on  [gi|1720357235|ref|XP_006529948|]
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ly6/PLAUR domain-containing protein 1 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_LYPD1 cd23559
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar ...
 46-131 1.27e-39

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar proteins; LYPD1 (also called putative HeLa tumor suppressor (PHTS)) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro LYPD1 increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. It may play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It may be involved in the control of anxiety. LYPD1 also functions as a novel putative tumor suppressor involved in the transformation reversion of HeLaHF cells independently of the p53 pathway. LYPD1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467089  Cd Length: 85  Bit Score: 129.27  E-value: 1.27e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357235  46 QIQCYQCEEFQLNNDCSSPEFIVNCTVnVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCC 125
Cdd:cd23559     1 QIQCYQCETFQLNDDCSSPEFIVNCTS-VQDMCQKEVMNHSAGIMYRKSCAQSAACLIASAGYQSFCTPGKVGSVCISCC 79


                  ....*.
gi 1720357235 126 NTPLCN 131
Cdd:cd23559    80 NTPLCN 85
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD1 cd23559
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar ...
 46-131 1.27e-39

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar proteins; LYPD1 (also called putative HeLa tumor suppressor (PHTS)) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro LYPD1 increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. It may play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It may be involved in the control of anxiety. LYPD1 also functions as a novel putative tumor suppressor involved in the transformation reversion of HeLaHF cells independently of the p53 pathway. LYPD1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467089  Cd Length: 85  Bit Score: 129.27  E-value: 1.27e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357235  46 QIQCYQCEEFQLNNDCSSPEFIVNCTVnVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCC 125
Cdd:cd23559     1 QIQCYQCETFQLNDDCSSPEFIVNCTS-VQDMCQKEVMNHSAGIMYRKSCAQSAACLIASAGYQSFCTPGKVGSVCISCC 79


                  ....*.
gi 1720357235 126 NTPLCN 131
Cdd:cd23559    80 NTPLCN 85
 
Name Accession Description Interval E-value
TFP_LU_ECD_LYPD1 cd23559
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar ...
 46-131 1.27e-39

extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 1 (LYPD1) and similar proteins; LYPD1 (also called putative HeLa tumor suppressor (PHTS)) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro LYPD1 increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. It may play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It may be involved in the control of anxiety. LYPD1 also functions as a novel putative tumor suppressor involved in the transformation reversion of HeLaHF cells independently of the p53 pathway. LYPD1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467089  Cd Length: 85  Bit Score: 129.27  E-value: 1.27e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357235  46 QIQCYQCEEFQLNNDCSSPEFIVNCTVnVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCC 125
Cdd:cd23559     1 QIQCYQCETFQLNDDCSSPEFIVNCTS-VQDMCQKEVMNHSAGIMYRKSCAQSAACLIASAGYQSFCTPGKVGSVCISCC 79


                  ....*.
gi 1720357235 126 NTPLCN 131
Cdd:cd23559    80 NTPLCN 85
TFP_LU_ECD_CinHb4_like cd23539
extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; ...
 47-131 1.22e-06

extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; Four distinct globin genes have been identified in the Ciona genome. CinHb4 is encoded by the fourth globin gene. It shows an unusual extension at its N-terminus, which reveals a conserved region with similarity to the extracellular domain (ECD) of the TGF-beta receptor type I/II protein family involved in signal transduction. The functional relevance of these matches is currently unknown. The ECD belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467069  Cd Length: 91  Bit Score: 44.33  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357235  47 IQCYQCEEFQLNNDCSSPEFIVNCTVNvQDMCQKEVMEQSAGIMY-RKSCASSAACL------IASAGYQSFCSPGKLNS 119
Cdd:cd23539     1 LSCWTCDNASSNEECLANGTLVTCQSN-EESCQTEVRRRGGGVYLiSKGCKQRQACEnnkkqnFKAAWNPTQCNPESPNS 79

                          90
                  ....*....|..
gi 1720357235 120 VCISCCNTPLCN 131
Cdd:cd23539    80 VCRCCCSTDLCN 91
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 47-131 9.59e-06

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 41.70  E-value: 9.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720357235  47 IQCYQCEEFQLNNDCSSPEFIVNCTVNvQDMCQKEVMEQSAG-IMYRKSCASSAACLIASagyqSFCSPGKLNSVCISCC 125
Cdd:cd00117     1 LKCYQCNSSNDPNCCNSSPTLVTCSSP-ETFCRKIVGKVGGGeTLVIRGCATECECGCTE----CCSGTGTSGTTCTSCC 75


                  ....*.
gi 1720357235 126 NTPLCN 131
Cdd:cd00117    76 DTDLCN 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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