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Conserved domains on  [gi|569007281|ref|XP_006527155|]
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tolloid-like protein 2 isoform X1 [Mus musculus]

Protein Classification

ZnMc_BMP1_TLD and CUB domain-containing protein( domain architecture ID 10858003)

protein containing domains ZnMc_BMP1_TLD, CUB, EGF_CA, and FXa_inhibition

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_BMP1_TLD cd04281
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) ...
 26-201 2.10e-133

Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The drosophila protein tolloid and its Xenopus homologue xolloid cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning.


:

Pssm-ID: 239808 [Multi-domain]  Cd Length: 200  Bit Score: 396.04  E-value: 2.10e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  26 GTQRAIFKQAMRHWEKHTCVTFVERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHE 105
Cdd:cd04281   25 GSQRAMFKQAMRHWENFTCVTFVERTPEENYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 106 HTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVR 185
Cdd:cd04281  105 HTRPDRDDHVTIIRENIQPGQEYNFLKMEPEEVDSLGEPYDFDSIMHYARNTFSRGMFLDTILPKRDPNGVRPEIGQRTR 184

                        170
                 ....*....|....*.
gi 569007281 186 LSQGDIAQARKLYKCP 201
Cdd:cd04281  185 LSEGDIIQANKLYKCP 200
CUB pfam00431
CUB domain;
316-425 8.71e-53

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 179.03  E-value: 8.71e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  316 CGGDITKDAGQIQSPNYPDDYRPSKECVWRITVPDGFHVGLTFQSFEIERHDSCAYDYLEIRDGPTEDSTLIGHFCGYEK 395
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  396 PEAVKSSANRLWVKFVSDGSINKAGFAANF 425
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
472-581 4.04e-48

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 165.93  E-value: 4.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  472 CGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEGNDVCKYDFVEVRSGLSPDAKLHGKFCGSET 551
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  552 PEVITSQSNNMRVEFKSDNTVSKRGFRAHF 581
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
203-312 3.70e-43

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 152.06  E-value: 3.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  203 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDKI 282
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  283 PESLVSSDSRLWVEFRSSSSSLGKGFFAVY 312
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
628-737 2.49e-42

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 149.75  E-value: 2.49e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  628 CAYKISSAEGTLMSPNWPDKYPSRKECTWNISSTAGHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKK 707
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  708 PDPVVATGSSLFLRFYSDASVQRKGFQAVH 737
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
741-854 7.18e-37

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 133.96  E-value: 7.18e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  741 CGGRLKaevqTKELYSHAQFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEADCGYDFMEAYDGYDSSAPRLGRFC 820
Cdd:pfam00431   1 CGGVLT----DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 569007281  821 GSGPLEEIYSAGDSLMIRFHTDDTINKKGFHARY 854
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 432-468 1.19e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.17  E-value: 1.19e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 569007281  432 CSWpDHGGCEQRCVNTLGSYTCACDPGYELAADKKTC 468
Cdd:pfam14670   1 CSV-NNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 588-623 1.71e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.79  E-value: 1.71e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569007281  588 CAKDNGGCQQECVNTFGSYLCRCRNGYRLHENGHDC 623
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
ZnMc_BMP1_TLD cd04281
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) ...
 26-201 2.10e-133

Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The drosophila protein tolloid and its Xenopus homologue xolloid cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning.


Pssm-ID: 239808 [Multi-domain]  Cd Length: 200  Bit Score: 396.04  E-value: 2.10e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  26 GTQRAIFKQAMRHWEKHTCVTFVERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHE 105
Cdd:cd04281   25 GSQRAMFKQAMRHWENFTCVTFVERTPEENYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 106 HTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVR 185
Cdd:cd04281  105 HTRPDRDDHVTIIRENIQPGQEYNFLKMEPEEVDSLGEPYDFDSIMHYARNTFSRGMFLDTILPKRDPNGVRPEIGQRTR 184

                        170
                 ....*....|....*.
gi 569007281 186 LSQGDIAQARKLYKCP 201
Cdd:cd04281  185 LSEGDIIQANKLYKCP 200
Astacin pfam01400
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
 26-202 1.82e-90

Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.


Pssm-ID: 426242 [Multi-domain]  Cd Length: 192  Bit Score: 284.17  E-value: 1.82e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   26 GTQRAIFKQAMRHWEKHTCVTFVERTDE-ESFIVFSYRTCGCCSYVGRRGGgPQAISIGKNCDKFGIVAHELGHVVGFWH 104
Cdd:pfam01400  18 GLARALIRQAMRHWENKTCIRFVERTPApDNNYLFFFKGDGCYSYVGRVGG-RQPVSIGDGCDKFGIIVHELGHALGFFH 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  105 EHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRrdDNGVRPTIGQRV 184
Cdd:pfam01400  97 EQSRPDRDDYVSINWDNIDPGQEGNFDKYDPSEVDSYGVPYDYGSIMHYGPNAFSKNGSLPTIVPK--DNDYQATIGQRV 174

                         170
                  ....*....|....*...
gi 569007281  185 RLSQGDIAQARKLYKCPA 202
Cdd:pfam01400 175 KLSFYDIKKINKLYKCPS 192
CUB pfam00431
CUB domain;
316-425 8.71e-53

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 179.03  E-value: 8.71e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  316 CGGDITKDAGQIQSPNYPDDYRPSKECVWRITVPDGFHVGLTFQSFEIERHDSCAYDYLEIRDGPTEDSTLIGHFCGYEK 395
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  396 PEAVKSSANRLWVKFVSDGSINKAGFAANF 425
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
472-581 4.04e-48

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 165.93  E-value: 4.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  472 CGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEGNDVCKYDFVEVRSGLSPDAKLHGKFCGSET 551
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  552 PEVITSQSNNMRVEFKSDNTVSKRGFRAHF 581
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
203-312 3.70e-43

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 152.06  E-value: 3.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  203 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDKI 282
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  283 PESLVSSDSRLWVEFRSSSSSLGKGFFAVY 312
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
628-737 2.49e-42

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 149.75  E-value: 2.49e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  628 CAYKISSAEGTLMSPNWPDKYPSRKECTWNISSTAGHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKK 707
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  708 PDPVVATGSSLFLRFYSDASVQRKGFQAVH 737
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 472-583 7.89e-42

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 148.33  E-value: 7.89e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 472 CGGFIT-KLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEGNDVCKYDFVEVRSGLSPDAKLHGKFCGSE 550
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 569007281 551 TPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFS 583
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 316-426 9.40e-42

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 148.33  E-value: 9.40e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 316 CGGDITKDA-GQIQSPNYPDDYRPSKECVWRITVPDGFHVGLTFQSFEIERHDSCAYDYLEIRDGPTEDSTLIGHFCGYE 394
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 569007281 395 KPEAVKSSANRLWVKFVSDGSINKAGFAANFF 426
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 325-425 1.00e-41

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 147.54  E-value: 1.00e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   325 GQIQSPNYPDDYRPSKECVWRITVPDGFHVGLTFQSFEIERHDSCAYDYLEIRDGPTEDSTLIGHFCGYEKPEAVKSSA- 403
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSs 80

                           90       100
                   ....*....|....*....|..
gi 569007281   404 NRLWVKFVSDGSINKAGFAANF 425
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 481-581 7.41e-41

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 145.23  E-value: 7.41e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   481 GTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEGNDVCKYDFVEVRSGLSPDAKLHGKFCGSETPE-VITSQS 559
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPpVISSSS 80

                           90       100
                   ....*....|....*....|..
gi 569007281   560 NNMRVEFKSDNTVSKRGFRAHF 581
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 203-314 1.77e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 138.70  E-value: 1.77e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 203 CGETLQDTT-GNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDK 281
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 569007281 282 IPESLVSSDSRLWVEFRSSSSSLGKGFFAVYEA 314
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 632-739 8.15e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 136.77  E-value: 8.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 632 ISSAEGTLMSPNWPDKYPSRKECTWNISSTAGHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKKPDPV 711
Cdd:cd00041    6 TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPI 85

                         90       100
                 ....*....|....*....|....*...
gi 569007281 712 VATGSSLFLRFYSDASVQRKGFQAVHST 739
Cdd:cd00041   86 ISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
741-854 7.18e-37

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 133.96  E-value: 7.18e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  741 CGGRLKaevqTKELYSHAQFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEADCGYDFMEAYDGYDSSAPRLGRFC 820
Cdd:pfam00431   1 CGGVLT----DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 569007281  821 GSGPLEEIYSAGDSLMIRFHTDDTINKKGFHARY 854
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 212-312 5.42e-36

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 131.36  E-value: 5.42e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   212 GNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDKIPESLVSSDS 291
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|..
gi 569007281   292 -RLWVEFRSSSSSLGKGFFAVY 312
Cdd:smart00042  81 nSLTLTFVSDSSVQKRGFSARY 102
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 27-149 9.38e-36

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 132.09  E-value: 9.38e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281    27 TQRAIFKQAMRHWEKHTCVTFVERTDEE-SFIVFSYRTCGCC-SYVGRRGGGpQAISIGKNCDKFGIVAHELGHVVGFWH 104
Cdd:smart00235  22 EEREAIAKALAEWSDVTCIRFVERTGTAdIYISFGSGDSGCTlSHAGRPGGD-QHLSLGNGCINTGVAAHELGHALGLYH 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 569007281   105 EHTRPDRDQHVTIIRENIQPGqeyNFLKMeagEVSSLGETYDFDS 149
Cdd:smart00235 101 EQSRSDRDNYMYINYTNIDTR---NFDLS---EDDSLGIPYDYGS 139
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 637-735 1.03e-35

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 130.59  E-value: 1.03e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   637 GTLMSPNWPDKYPSRKECTWNISSTAGHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKKPDPVVAT-G 715
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsS 80

                           90       100
                   ....*....|....*....|
gi 569007281   716 SSLFLRFYSDASVQRKGFQA 735
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSA 100
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 741-856 2.46e-32

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 121.37  E-value: 2.46e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 741 CGGRLKAEvQTKELYSHaqFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEADCGYDFMEAYDGYDSSAPRLGRFC 820
Cdd:cd00041    1 CGGTLTAS-TSGTISSP--NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 569007281 821 GSGPLEEIYSAGDSLMIRFHTDDTINKKGFHARYTS 856
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 763-854 1.05e-28

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 110.56  E-value: 1.05e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   763 NNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEADCGYDFMEAYDGYDSSAPRLGRFCGSGPLEE-IYSAGDSLMIRFHT 841
Cdd:smart00042  10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNSLTLTFVS 89

                           90
                   ....*....|...
gi 569007281   842 DDTINKKGFHARY 854
Cdd:smart00042  90 DSSVQKRGFSARY 102
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 432-468 1.19e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.17  E-value: 1.19e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 569007281  432 CSWpDHGGCEQRCVNTLGSYTCACDPGYELAADKKTC 468
Cdd:pfam14670   1 CSV-NNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 588-623 1.71e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.79  E-value: 1.71e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569007281  588 CAKDNGGCQQECVNTFGSYLCRCRNGYRLHENGHDC 623
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
428-469 2.05e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 2.05e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 569007281   428 EVDECSwpDHGGCEQ--RCVNTLGSYTCACDPGYElaaDKKTCE 469
Cdd:smart00179   1 DIDECA--SGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 408-467 3.23e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 48.92  E-value: 3.23e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007281 408 VKFVSDGS-INKAG--FAANFFKEVDECSWPDHGgCEQRCVNTLGSYTCACDPGYELAADKKT 467
Cdd:cd01475  163 VFYVEDFStIEELTkkFQGKICVVPDLCATLSHV-CQQVCISTPGSYLCACTEGYALLEDNKT 224
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 566-620 9.48e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 47.76  E-value: 9.48e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 569007281 566 FKSDNTVSKRgFRAHFFSDKDECAKDNGGCQQECVNTFGSYLCRCRNGYRLHENG 620
Cdd:cd01475  169 FSTIEELTKK-FQGKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDN 222
EGF_CA smart00179
Calcium-binding EGF-like domain;
584-624 1.35e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.35e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 569007281   584 DKDECAkDNGGCQQ--ECVNTFGSYLCRCRNGYrlhENGHDCK 624
Cdd:smart00179   1 DIDECA-SGNPCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
 
Name Accession Description Interval E-value
ZnMc_BMP1_TLD cd04281
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) ...
 26-201 2.10e-133

Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The drosophila protein tolloid and its Xenopus homologue xolloid cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning.


Pssm-ID: 239808 [Multi-domain]  Cd Length: 200  Bit Score: 396.04  E-value: 2.10e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  26 GTQRAIFKQAMRHWEKHTCVTFVERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHE 105
Cdd:cd04281   25 GSQRAMFKQAMRHWENFTCVTFVERTPEENYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 106 HTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVR 185
Cdd:cd04281  105 HTRPDRDDHVTIIRENIQPGQEYNFLKMEPEEVDSLGEPYDFDSIMHYARNTFSRGMFLDTILPKRDPNGVRPEIGQRTR 184

                        170
                 ....*....|....*.
gi 569007281 186 LSQGDIAQARKLYKCP 201
Cdd:cd04281  185 LSEGDIIQANKLYKCP 200
Astacin pfam01400
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
 26-202 1.82e-90

Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.


Pssm-ID: 426242 [Multi-domain]  Cd Length: 192  Bit Score: 284.17  E-value: 1.82e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   26 GTQRAIFKQAMRHWEKHTCVTFVERTDE-ESFIVFSYRTCGCCSYVGRRGGgPQAISIGKNCDKFGIVAHELGHVVGFWH 104
Cdd:pfam01400  18 GLARALIRQAMRHWENKTCIRFVERTPApDNNYLFFFKGDGCYSYVGRVGG-RQPVSIGDGCDKFGIIVHELGHALGFFH 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  105 EHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRrdDNGVRPTIGQRV 184
Cdd:pfam01400  97 EQSRPDRDDYVSINWDNIDPGQEGNFDKYDPSEVDSYGVPYDYGSIMHYGPNAFSKNGSLPTIVPK--DNDYQATIGQRV 174

                         170
                  ....*....|....*...
gi 569007281  185 RLSQGDIAQARKLYKCPA 202
Cdd:pfam01400 175 KLSFYDIKKINKLYKCPS 192
ZnMc_astacin_like cd04280
Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of ...
 27-198 2.99e-71

Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to yield the active protease domain, which is consequently always found at the N-terminus in multi-domain architectures. This family includes: astacin, a digestive enzyme from Crayfish; meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain, proteins involved in (bone) morphogenesis, tolloid from drosophila, and the sea urchin SPAN protein, which may also play a role in development.


Pssm-ID: 239807 [Multi-domain]  Cd Length: 180  Bit Score: 232.46  E-value: 2.99e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  27 TQRAIFKQAMRHWEKHTCVTFVERTDEESFIVFSYRTcGCCSYVGRRGGgPQAISIGKNCDKFGIVAHELGHVVGFWHEH 106
Cdd:cd04280   15 SDRSLILRAMREIESNTCIRFVPRTTEKDYIRIVKGS-GCWSYVGRVGG-RQVVSLGSGCFSLGTIVHELMHALGFYHEQ 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 107 TRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVfLDTILPRRDDNGvrpTIGQRVRL 186
Cdd:cd04280   93 SRPDRDDYVTINWENIQPGYEHNFDKYSPDTVTTYGVPYDYGSVMHYGPTAFSKNG-KPTIVPKDPGYQ---IIGQREGL 168

                        170
                 ....*....|..
gi 569007281 187 SQGDIAQARKLY 198
Cdd:cd04280  169 SFLDIKKINKMY 180
ZnMc_hatching_enzyme cd04283
Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted ...
 28-200 4.29e-56

Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related metalloproteases, high choriolytic enzyme and low choriolytic enzyme (HCE and LCE), which may have different substrate specificities and cooperatively digest the chorion.


Pssm-ID: 239810 [Multi-domain]  Cd Length: 182  Bit Score: 190.94  E-value: 4.29e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  28 QRAIFKQAMRHWEKHTCVTFVERTDEESFIVFSYRTcGCCSYVGRRGGGpQAISIGKN-CDKFGIVAHELGHVVGFWHEH 106
Cdd:cd04283   18 ERAVIEKAMQEFETLTCVRFVPRTTERDYLNIESRS-GCWSYIGRQGGR-QTVSLQKQgCMYKGIIQHELLHALGFYHEQ 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 107 TRPDRDQHVTIIRENIQPGQEYNFLKMEAgevSSLGETYDFDSIMHYARNTFSRGvFLDTILPRRDDNgvrPTIGQRVRL 186
Cdd:cd04283   96 TRSDRDKYVRINWENIIPDQLYNFDKQDT---NNLGTPYDYSSVMHYGRYAFSIN-GKPTIVPIPDPN---VPIGQRQGM 168

                        170
                 ....*....|....
gi 569007281 187 SQGDIAQARKLYKC 200
Cdd:cd04283  169 SNLDILRINKLYNC 182
CUB pfam00431
CUB domain;
316-425 8.71e-53

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 179.03  E-value: 8.71e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  316 CGGDITKDAGQIQSPNYPDDYRPSKECVWRITVPDGFHVGLTFQSFEIERHDSCAYDYLEIRDGPTEDSTLIGHFCGYEK 395
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  396 PEAVKSSANRLWVKFVSDGSINKAGFAANF 425
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
472-581 4.04e-48

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 165.93  E-value: 4.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  472 CGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEGNDVCKYDFVEVRSGLSPDAKLHGKFCGSET 551
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  552 PEVITSQSNNMRVEFKSDNTVSKRGFRAHF 581
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
203-312 3.70e-43

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 152.06  E-value: 3.70e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  203 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDKI 282
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  283 PESLVSSDSRLWVEFRSSSSSLGKGFFAVY 312
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
628-737 2.49e-42

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 149.75  E-value: 2.49e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  628 CAYKISSAEGTLMSPNWPDKYPSRKECTWNISSTAGHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKK 707
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 569007281  708 PDPVVATGSSLFLRFYSDASVQRKGFQAVH 737
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 472-583 7.89e-42

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 148.33  E-value: 7.89e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 472 CGGFIT-KLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEGNDVCKYDFVEVRSGLSPDAKLHGKFCGSE 550
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 569007281 551 TPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFS 583
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 316-426 9.40e-42

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 148.33  E-value: 9.40e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 316 CGGDITKDA-GQIQSPNYPDDYRPSKECVWRITVPDGFHVGLTFQSFEIERHDSCAYDYLEIRDGPTEDSTLIGHFCGYE 394
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 569007281 395 KPEAVKSSANRLWVKFVSDGSINKAGFAANFF 426
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 325-425 1.00e-41

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 147.54  E-value: 1.00e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   325 GQIQSPNYPDDYRPSKECVWRITVPDGFHVGLTFQSFEIERHDSCAYDYLEIRDGPTEDSTLIGHFCGYEKPEAVKSSA- 403
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSs 80

                           90       100
                   ....*....|....*....|..
gi 569007281   404 NRLWVKFVSDGSINKAGFAANF 425
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 481-581 7.41e-41

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 145.23  E-value: 7.41e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   481 GTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEAFELEGNDVCKYDFVEVRSGLSPDAKLHGKFCGSETPE-VITSQS 559
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPpVISSSS 80

                           90       100
                   ....*....|....*....|..
gi 569007281   560 NNMRVEFKSDNTVSKRGFRAHF 581
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 203-314 1.77e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 138.70  E-value: 1.77e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 203 CGETLQDTT-GNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDK 281
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 569007281 282 IPESLVSSDSRLWVEFRSSSSSLGKGFFAVYEA 314
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 632-739 8.15e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 136.77  E-value: 8.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 632 ISSAEGTLMSPNWPDKYPSRKECTWNISSTAGHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKKPDPV 711
Cdd:cd00041    6 TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPI 85

                         90       100
                 ....*....|....*....|....*...
gi 569007281 712 VATGSSLFLRFYSDASVQRKGFQAVHST 739
Cdd:cd00041   86 ISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
741-854 7.18e-37

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 133.96  E-value: 7.18e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  741 CGGRLKaevqTKELYSHAQFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEADCGYDFMEAYDGYDSSAPRLGRFC 820
Cdd:pfam00431   1 CGGVLT----DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 569007281  821 GSGPLEEIYSAGDSLMIRFHTDDTINKKGFHARY 854
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 212-312 5.42e-36

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 131.36  E-value: 5.42e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   212 GNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNFTSMDLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDKIPESLVSSDS 291
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|..
gi 569007281   292 -RLWVEFRSSSSSLGKGFFAVY 312
Cdd:smart00042  81 nSLTLTFVSDSSVQKRGFSARY 102
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 27-149 9.38e-36

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 132.09  E-value: 9.38e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281    27 TQRAIFKQAMRHWEKHTCVTFVERTDEE-SFIVFSYRTCGCC-SYVGRRGGGpQAISIGKNCDKFGIVAHELGHVVGFWH 104
Cdd:smart00235  22 EEREAIAKALAEWSDVTCIRFVERTGTAdIYISFGSGDSGCTlSHAGRPGGD-QHLSLGNGCINTGVAAHELGHALGLYH 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 569007281   105 EHTRPDRDQHVTIIRENIQPGqeyNFLKMeagEVSSLGETYDFDS 149
Cdd:smart00235 101 EQSRSDRDNYMYINYTNIDTR---NFDLS---EDDSLGIPYDYGS 139
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 637-735 1.03e-35

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 130.59  E-value: 1.03e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   637 GTLMSPNWPDKYPSRKECTWNISSTAGHRVKITFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKKPDPVVAT-G 715
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsS 80

                           90       100
                   ....*....|....*....|
gi 569007281   716 SSLFLRFYSDASVQRKGFQA 735
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSA 100
ZnMc_meprin cd04282
Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted ...
 24-200 4.47e-34

Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as osteopontin, and proteins such as collagen IV, fibronectin, casein and gelatin. Meprins may also be able to release proteins from the cell surface. Closely related meprin alpha- and beta-subunits form homo- and hetero-oligomers; these complexes are found on epithelial cells of the intestine, for example, and are also expressed in certain cancer cells.


Pssm-ID: 239809 [Multi-domain]  Cd Length: 230  Bit Score: 130.67  E-value: 4.47e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  24 DLGTQRAIFKqAMRHWEKHTCVTFVERTDEESFIVFsYRTCGCCSYVGRRGGGpQAISIGKNCDKFGIVAHELGHVVGFW 103
Cdd:cd04282   59 DLNAKGVILK-AFEMYRLKSCVDFKPYEGESNYIFF-FKGSGCWSMVGDQQGG-QNLSIGAGCDYKATVEHEFLHALGFY 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 104 HEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDD-NGVrptIGQ 182
Cdd:cd04282  136 HEQSRSDRDDYVKIWWDQILSGREHNFNKYDDSFSTDLNTPYDYESVMHYSPFSFNKGASEPTITTKIPEfNDI---IGQ 212

                        170
                 ....*....|....*...
gi 569007281 183 RVRLSQGDIAQARKLYKC 200
Cdd:cd04282  213 RLDFSDIDLERLNRMYNC 230
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 741-856 2.46e-32

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 121.37  E-value: 2.46e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281 741 CGGRLKAEvQTKELYSHaqFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEADCGYDFMEAYDGYDSSAPRLGRFC 820
Cdd:cd00041    1 CGGTLTAS-TSGTISSP--NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 569007281 821 GSGPLEEIYSAGDSLMIRFHTDDTINKKGFHARYTS 856
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 763-854 1.05e-28

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 110.56  E-value: 1.05e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281   763 NNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEADCGYDFMEAYDGYDSSAPRLGRFCGSGPLEE-IYSAGDSLMIRFHT 841
Cdd:smart00042  10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNSLTLTFVS 89

                           90
                   ....*....|...
gi 569007281   842 DDTINKKGFHARY 854
Cdd:smart00042  90 DSSVQKRGFSARY 102
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 26-198 4.21e-23

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 96.82  E-value: 4.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  26 GTQRAIFKQAMRHWEKHTCVTFVERTDEES---FIVFSYRT-----CGCCSYVGR-RGGGPQAISIGKNC----DKFGIV 92
Cdd:cd00203   21 AQIQSLILIAMQIWRDYLNIRFVLVGVEIDkadIAILVTRQdfdggTGGWAYLGRvCDSLRGVGVLQDNQsgtkEGAQTI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  93 AHELGHVVGFWHEHTRPDRDQHVTIireniqpgqeynflkmeagEVSSLGETYDFDSIMHYARNTFSrgvfldtilprrd 172
Cdd:cd00203  101 AHELGHALGFYHDHDRKDRDDYPTI-------------------DDTLNAEDDDYYSVMSYTKGSFS------------- 148

                        170       180
                 ....*....|....*....|....*.
gi 569007281 173 dngvrptIGQRVRLSQGDIAQARKLY 198
Cdd:cd00203  149 -------DGQRKDFSQCDIDQINKLY 167
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 29-198 4.15e-17

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 79.46  E-value: 4.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  29 RAIFKQAMRHWEKHTCVTFVERTDEES--FIVFSYR----TCGCCSYVGRRGGGPQA-ISIGKNCD-----------KFG 90
Cdd:cd04268   17 RAAILDAIEAWNKAFAIGFKNANDVDPadIRYSVIRwipyNDGTWSYGPSQVDPLTGeILLARVYLyssfveysgarLRN 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  91 IVAHELGHVVGFWHEHTRPDRDQHVTIireniqpgqeynflkmeagevssLGETYDFDSIMHYARNTFSrgvfldtilpr 170
Cdd:cd04268   97 TAEHELGHALGLRHNFAASDRDDNVDL-----------------------LAEKGDTSSVMDYAPSNFS----------- 142

                        170       180
                 ....*....|....*....|....*...
gi 569007281 171 rddngVRPTIGQRVRLSQGDIAQARKLY 198
Cdd:cd04268  143 -----IQLGDGQKYTIGPYDIAAIKKLY 165
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 432-468 1.19e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.17  E-value: 1.19e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 569007281  432 CSWpDHGGCEQRCVNTLGSYTCACDPGYELAADKKTC 468
Cdd:pfam14670   1 CSV-NNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 588-623 1.71e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.79  E-value: 1.71e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569007281  588 CAKDNGGCQQECVNTFGSYLCRCRNGYRLHENGHDC 623
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
ZnMc_MMP_like_3 cd04327
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal ...
 27-198 2.33e-09

Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239819 [Multi-domain]  Cd Length: 198  Bit Score: 57.78  E-value: 2.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  27 TQRAIFKQAMRHWEKHTCVTFVERTDEESFIVFSYRTC-GCCSYVGRrgggpQAISIGK-----NCDKFG---------- 90
Cdd:cd04327   20 FLKDKVRAAAREWLPYANLKFKFVTDADADIRISFTPGdGYWSYVGT-----DALLIGAdaptmNLGWFTddtpdpefsr 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  91 IVAHELGHVVGFWHEHTRPD-----RDQHV-------------TIIRENIqpgqeynFLKMEAGEVSslGETYDFDSIMH 152
Cdd:cd04327   95 VVLHEFGHALGFIHEHQSPAanipwDKEAVyayfsgppnwdreTVINHNV-------FAKLDDGDVA--YSPYDPDSIMH 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 569007281 153 YArntFSRGVFLDTilprrddngvRPTIGQRVrLSQGDIAQARKLY 198
Cdd:cd04327  166 YP---FPGSLTLDG----------EEVPPNRT-LSDKDKAFMRLLY 197
EGF_CA smart00179
Calcium-binding EGF-like domain;
428-469 2.05e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 2.05e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 569007281   428 EVDECSwpDHGGCEQ--RCVNTLGSYTCACDPGYElaaDKKTCE 469
Cdd:smart00179   1 DIDECA--SGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 408-467 3.23e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 48.92  E-value: 3.23e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007281 408 VKFVSDGS-INKAG--FAANFFKEVDECSWPDHGgCEQRCVNTLGSYTCACDPGYELAADKKT 467
Cdd:cd01475  163 VFYVEDFStIEELTkkFQGKICVVPDLCATLSHV-CQQVCISTPGSYLCACTEGYALLEDNKT 224
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 566-620 9.48e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 47.76  E-value: 9.48e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 569007281 566 FKSDNTVSKRgFRAHFFSDKDECAKDNGGCQQECVNTFGSYLCRCRNGYRLHENG 620
Cdd:cd01475  169 FSTIEELTKK-FQGKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDN 222
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 429-469 9.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 9.52e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 569007281 429 VDECSwpDHGGCE--QRCVNTLGSYTCACDPGYELaadkKTCE 469
Cdd:cd00054    2 IDECA--SGNPCQngGTCVNTVGSYRCSCPPGYTG----RNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
584-624 1.35e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.35e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 569007281   584 DKDECAkDNGGCQQ--ECVNTFGSYLCRCRNGYrlhENGHDCK 624
Cdd:smart00179   1 DIDECA-SGNPCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
ZnMc_MMP_like_1 cd04279
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
 33-110 6.14e-05

Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239806 [Multi-domain]  Cd Length: 156  Bit Score: 43.98  E-value: 6.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007281  33 KQAMRHWEKHTCVTFVERTDEES---FIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKF-------------------G 90
Cdd:cd04279   27 KQAAAEWENVGPLKFVYNPEEDNdadIVIFFDRPPPVGGAGGGLARAGFPLISDGNRKLFnrtdinlgpgqprgaenlqA 106

                         90       100
                 ....*....|....*....|
gi 569007281  91 IVAHELGHVVGFWHEHTRPD 110
Cdd:cd04279  107 IALHELGHALGLWHHSDRPE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 584-617 8.59e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 8.59e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 569007281 584 DKDECAkDNGGCQ--QECVNTFGSYLCRCRNGYRLH 617
Cdd:cd00054    1 DIDECA-SGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 431-469 7.46e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.84  E-value: 7.46e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 569007281 431 ECSwpDHGGCE--QRCVNTLGSYTCACDPGYELaadKKTCE 469
Cdd:cd00053    1 ECA--ASNPCSngGTCVNTPGSYRCVCPPGYTG---DRSCE 36
EGF smart00181
Epidermal growth factor-like domain;
431-469 1.05e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 569007281   431 ECSwpDHGGCEQ-RCVNTLGSYTCACDPGYELAadkKTCE 469
Cdd:smart00181   1 ECA--SGGPCSNgTCINTPGSYTCSCPPGYTGD---KRCE 35
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 436-468 1.39e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 1.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 569007281  436 DHGGC--EQRCVNTLGSYTCACDPGYELaaDKKTC 468
Cdd:pfam12947   4 NNGGChpNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF smart00181
Epidermal growth factor-like domain;
587-619 4.52e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.57  E-value: 4.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 569007281   587 ECAkDNGGCQQ-ECVNTFGSYLCRCRNGYRLHEN 619
Cdd:smart00181   1 ECA-SGGPCSNgTCINTPGSYTCSCPPGYTGDKR 33
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 587-619 7.40e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 7.40e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 569007281 587 ECAkDNGGCQ--QECVNTFGSYLCRCRNGYRLHEN 619
Cdd:cd00053    1 ECA-ASNPCSngGTCVNTPGSYRCVCPPGYTGDRS 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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