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Conserved domains on  [gi|569005364|ref|XP_006526555|]
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zinc finger protein 236 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
646-1051 1.07e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  646 NEADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRG--FVSAGVLKAHVRTHTGLKSFKCLICNG-AFTTGGS 722
Cdd:COG5048    28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPlSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  723 LRRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQEaSSMDDDSTVDQQSMHVAAPMPVEIESAELQ 802
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNS-SSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  803 QTPETVAADPESILELGPQHvvgtedaalgqQLADQPLEADEDGFTASQAPLPGHMDQFEEQGTPQPSfesagLPQGFTV 882
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLS-----------SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-----SPSSLSS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  883 TDTYSQQTSFPPVQQLQDSSTLESQALSTSFHQQNLLQVPNSDAINvatrllPESSQEDlDLQTQGPQFLEDSEDQSRRS 962
Cdd:COG5048   251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCN------ISFSRSS-PLTRHLRSVNHSGESLKPFS 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  963 YRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKS-------HEKTHTGVKAFSC--SICNASFTTNGS 1033
Cdd:COG5048   324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSN 403

                         410
                  ....*....|....*...
gi 569005364 1034 LTRHMATHMSMKPYKCPF 1051
Cdd:COG5048   404 LSLHIITHLSFRPYNCKN 421
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 1333-1609 4.76e-08

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 58.62  E-value: 4.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1333 ASVSAGGDLTVSL--TDGSLATLEGIQLQLAANLVGPNVQIS--GIDASSINNITLQIDPSILQQTLQQGSLLAQPITGE 1408
Cdd:COG3210   802 GTITAAGTTAINVtgSGGTITINTATTGLTGTGDTTSGAGGSntTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGS 881

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1409 SSTASQNSSLQTSDSTVPASVVIQPLSGLSLQPTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVSTSTGphe 1488
Cdd:COG3210   882 GGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAAS--- 958

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1489 ITLTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLA 1568
Cdd:COG3210   959 ASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAA 1038

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 569005364 1569 DTQGVLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGS 1609
Cdd:COG3210  1039 TAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGG 1079
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-543 5.54e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 5.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  190 FPYSCPHCGKTFQKPSQLTRHIRIHTGERPFKCSECGKAFNQK--GALQTHMIKHTGEKPHACAfcpaafsqKGNLQSHV 267
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNS--------KSLPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  268 QRVHSEVKNGPTYNCTECSCVFKSLG------SLNTHISKMHMGGPPNSTTSaeTAHVITATIFQTLPLQQVEAQVSSVS 341
Cdd:COG5048   104 KASSSSLSSSSSNSNDNNLLSSHSLPpssrdpQLPDLLSISNLRNNPLPGNN--SSSVNTPQSNSLHPPLPANSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  342 SEQSSQAVSDVIQQLLELSEPGPVEAQQSPQSgrQLSVTVGINQDILQQALENSGLSslpvaaPPSDCSHAQTATVSTQS 421
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPS--SSSDQNLENSSSSLPLTTNSQLS------PKSLLSQSPSSLSSSDS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  422 PHASSVSAEQADPMDAEQEKgqespektdkkekkllkkkSPFLPGSIREENGVRWHVCPYCTKEFRKPSDLVRHIRIHTH 501
Cdd:COG5048   254 SSSASESPRSSLPTASSQSS-------------------SPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNH 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 569005364  502 E----KPFKCP--QCFRAFAVKSTLTAHIKTHTGIKAFKCQY--CMKSFS 543
Cdd:COG5048   315 SgeslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFS 364
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1177-1201 2.67e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.44  E-value: 2.67e-06
                           10        20
                   ....*....|....*....|....*
gi 569005364  1177 DLVRHVRIHTGEKPYKCDECGKSFT 1201
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
930-1310 4.11e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  930 ATRLLPESSQEDLDLQTQGPQFLEDSEDQSRRSYRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKSH 1009
Cdd:COG5048     1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1010 ---EKTHTGVKAFSCSICNASFTTNGSLTRHMATHMSMKPYKCPFCEEgfrtavhcrKHMKRHQAVSSAAAAAAETEGGD 1086
Cdd:COG5048    81 rhlRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSL---------PPSSRDPQLPDLLSISNLRNNPL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1087 TCVEEDEENSDRSASRKPRPEVITFTEEETAQLAKIqPQESATVSEKV------LVQSAAEKDRISEMKDKQAELEAEPK 1160
Cdd:COG5048   152 PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL-ISSNVSTSIPSssenspLSSSYSIPSSSSDQNLENSSSSLPLT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1161 HANCCTYCPKSFKKPSDLVRHVRIHTGEKPYKCDECGKSFTVKSTLDCHVKTHTGQKLFSCH-VCSNAFSTKGSLKVHMR 1239
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSkQCNISFSRSSPLTRHLR 310

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569005364 1240 --LHTG--AKPFKCPH--CELRFRTSGRRKTHMQFHYKSDPKKarKPVTRSSSESLQSVNLLNSSSTDPNVFIMNNS 1310
Cdd:COG5048   311 svNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK--EKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDK 385
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1733-1757 1.15e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 1.15e-05
                           10        20
                   ....*....|....*....|....*
gi 569005364  1733 LERHSRIHTGERPFHCTLCDKAFNQ 1757
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 2.16e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 2.16e-04
                           10        20
                   ....*....|....*....|....*.
gi 569005364   547 SLKVHIRLHTGVRPFACPHCDKKFRT 572
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
23-227 1.41e-03

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364   23 DDDCPIPNFHKCEICLLSFPKESQFQRHMREHEQNDKPHRCDQCPQTFNVEFNLTLHKCTHNAEDP-----VCPV--CNK 95
Cdd:COG5048   252 DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGEslkpfSCPYslCGK 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364   96 KFSRVASLKAHIMLHEKEENLICSECGDEFTLHSqlAIHMEEHRQELANTRAHTckacKKEFETSPELKEhmkTHCKVRA 175
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP--LLNNEPPQSLQQYKDLKN----DKKSETLSNSCI---RNFKRDS 402

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569005364  176 SGTRSYNRNIDRSSFPYSCPHCGKTFQKPSQLTRHIRIHTGERPFKCSECGK 227
Cdd:COG5048   403 NLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1760-1785 1.45e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 1.45e-03
                           10        20
                   ....*....|....*....|....*.
gi 569005364  1760 ALQVHLKKHTGERPYRCDYCVMGFTQ 1785
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1655-1703 2.49e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 569005364 1655 CLDCDRAFSSAAVLMHHSKEVHGKerihgCRVCRKAFKRATHLKEHMLT 1703
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKHFK-----CHICHKKLYTAGGLAVHCLQ 47
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
646-1051 1.07e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  646 NEADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRG--FVSAGVLKAHVRTHTGLKSFKCLICNG-AFTTGGS 722
Cdd:COG5048    28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPlSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  723 LRRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQEaSSMDDDSTVDQQSMHVAAPMPVEIESAELQ 802
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNS-SSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  803 QTPETVAADPESILELGPQHvvgtedaalgqQLADQPLEADEDGFTASQAPLPGHMDQFEEQGTPQPSfesagLPQGFTV 882
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLS-----------SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-----SPSSLSS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  883 TDTYSQQTSFPPVQQLQDSSTLESQALSTSFHQQNLLQVPNSDAINvatrllPESSQEDlDLQTQGPQFLEDSEDQSRRS 962
Cdd:COG5048   251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCN------ISFSRSS-PLTRHLRSVNHSGESLKPFS 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  963 YRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKS-------HEKTHTGVKAFSC--SICNASFTTNGS 1033
Cdd:COG5048   324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSN 403

                         410
                  ....*....|....*...
gi 569005364 1034 LTRHMATHMSMKPYKCPF 1051
Cdd:COG5048   404 LSLHIITHLSFRPYNCKN 421
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 1333-1609 4.76e-08

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 58.62  E-value: 4.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1333 ASVSAGGDLTVSL--TDGSLATLEGIQLQLAANLVGPNVQIS--GIDASSINNITLQIDPSILQQTLQQGSLLAQPITGE 1408
Cdd:COG3210   802 GTITAAGTTAINVtgSGGTITINTATTGLTGTGDTTSGAGGSntTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGS 881

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1409 SSTASQNSSLQTSDSTVPASVVIQPLSGLSLQPTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVSTSTGphe 1488
Cdd:COG3210   882 GGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAAS--- 958

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1489 ITLTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLA 1568
Cdd:COG3210   959 ASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAA 1038

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 569005364 1569 DTQGVLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGS 1609
Cdd:COG3210  1039 TAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGG 1079
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-543 5.54e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 5.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  190 FPYSCPHCGKTFQKPSQLTRHIRIHTGERPFKCSECGKAFNQK--GALQTHMIKHTGEKPHACAfcpaafsqKGNLQSHV 267
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNS--------KSLPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  268 QRVHSEVKNGPTYNCTECSCVFKSLG------SLNTHISKMHMGGPPNSTTSaeTAHVITATIFQTLPLQQVEAQVSSVS 341
Cdd:COG5048   104 KASSSSLSSSSSNSNDNNLLSSHSLPpssrdpQLPDLLSISNLRNNPLPGNN--SSSVNTPQSNSLHPPLPANSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  342 SEQSSQAVSDVIQQLLELSEPGPVEAQQSPQSgrQLSVTVGINQDILQQALENSGLSslpvaaPPSDCSHAQTATVSTQS 421
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPS--SSSDQNLENSSSSLPLTTNSQLS------PKSLLSQSPSSLSSSDS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  422 PHASSVSAEQADPMDAEQEKgqespektdkkekkllkkkSPFLPGSIREENGVRWHVCPYCTKEFRKPSDLVRHIRIHTH 501
Cdd:COG5048   254 SSSASESPRSSLPTASSQSS-------------------SPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNH 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 569005364  502 E----KPFKCP--QCFRAFAVKSTLTAHIKTHTGIKAFKCQY--CMKSFS 543
Cdd:COG5048   315 SgeslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFS 364
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1177-1201 2.67e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.44  E-value: 2.67e-06
                           10        20
                   ....*....|....*....|....*
gi 569005364  1177 DLVRHVRIHTGEKPYKCDECGKSFT 1201
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
930-1310 4.11e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  930 ATRLLPESSQEDLDLQTQGPQFLEDSEDQSRRSYRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKSH 1009
Cdd:COG5048     1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1010 ---EKTHTGVKAFSCSICNASFTTNGSLTRHMATHMSMKPYKCPFCEEgfrtavhcrKHMKRHQAVSSAAAAAAETEGGD 1086
Cdd:COG5048    81 rhlRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSL---------PPSSRDPQLPDLLSISNLRNNPL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1087 TCVEEDEENSDRSASRKPRPEVITFTEEETAQLAKIqPQESATVSEKV------LVQSAAEKDRISEMKDKQAELEAEPK 1160
Cdd:COG5048   152 PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL-ISSNVSTSIPSssenspLSSSYSIPSSSSDQNLENSSSSLPLT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1161 HANCCTYCPKSFKKPSDLVRHVRIHTGEKPYKCDECGKSFTVKSTLDCHVKTHTGQKLFSCH-VCSNAFSTKGSLKVHMR 1239
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSkQCNISFSRSSPLTRHLR 310

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569005364 1240 --LHTG--AKPFKCPH--CELRFRTSGRRKTHMQFHYKSDPKKarKPVTRSSSESLQSVNLLNSSSTDPNVFIMNNS 1310
Cdd:COG5048   311 svNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK--EKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDK 385
zf-H2C2_2 pfam13465
Zinc-finger double domain;
977-1002 6.45e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 6.45e-06
                           10        20
                   ....*....|....*....|....*.
gi 569005364   977 HLKQHVRSHTGEKPYKCKLCGRAFVS 1002
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-231 6.77e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 6.77e-06
                           10        20
                   ....*....|....*....|....*
gi 569005364   207 LTRHIRIHTGERPFKCSECGKAFNQ 231
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1367-1668 1.11e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.69  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  1367 PNVQISGIDASSINNITLQIDPS----ILQQTLQQGSLLAQPITGESSTASQNSSLQTSDSTVPA---SVVIQPLSGLSL 1439
Cdd:pfam05109  567 PNATIPTLGKTSPTSAVTTPTPNatspTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTgqhNITSSSTSSMSL 646

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  1440 QPTVTSAnlTIGPLSEQDSV----LTTSS--SGSQDLSQVMTSqglvstSTGPHEITlTINNSSLSQVLAQAAGPTASSS 1513
Cdd:pfam05109  647 RPSSISE--TLSPSTSDNSTshmpLLTSAhpTGGENITQVTPA------STSTHHVS-TSSPAPRPGTTSQASGPGNSST 717

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  1514 SGSPQEITLTiselnpsSGSLP--STAPMSPSAISAQNLVMSSSGVGADASvtltladtqgvlSGGLDTvtlniTSQGQQ 1591
Cdd:pfam05109  718 STKPGEVNVT-------KGTPPknATSPQAPSGQKTAVPTVTSTGGKANST------------TGGKHT-----TGHGAR 773

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  1592 FPallTDPSLSGQGGAGSPQVILVSHT---PQSSSAAGEEIAYQVTDV-PAQLT----PHSQPEKEGLSHQCLDcdraFS 1663
Cdd:pfam05109  774 TS---TEPTTDYGGDSTTPRTRYNATTylpPSTSSKLRPRWTFTSPPVtTAQATvpvpPTSQPRFSNLSMLVLQ----WA 846


                   ....*
gi 569005364  1664 SAAVL 1668
Cdd:pfam05109  847 SLAVL 851
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1733-1757 1.15e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 1.15e-05
                           10        20
                   ....*....|....*....|....*
gi 569005364  1733 LERHSRIHTGERPFHCTLCDKAFNQ 1757
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 2.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 2.16e-04
                           10        20
                   ....*....|....*....|....*.
gi 569005364   547 SLKVHIRLHTGVRPFACPHCDKKFRT 572
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 650-701 2.26e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 2.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569005364  650 RPYkCFYCHRAYKKSCHLKQHIRSHTgekpFKCSQCGRGFVSAGVLKAHVRT 701
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1233-1258 5.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 5.98e-04
                           10        20
                   ....*....|....*....|....*.
gi 569005364  1233 SLKVHMRLHTGAKPFKCPHCELRFRT 1258
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 1355-1621 9.57e-04

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 44.14  E-value: 9.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1355 GIQLQLAANLV---GPNVQISGIDASSINNITLQIdpsilqQTLQQGSLLAqPITGESSTASQNSSLQ-TSDSTVPasVV 1430
Cdd:cd22536   141 SVQYQVIPQIQtveGQQIQISPANATALQDLQGQI------QLIPAGNNQA-ILTTPNRTASGNIIAQnLANQTVP--VQ 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1431 IQPLSGLSLQ---------PTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGlvSTSTGPHEITLTINNSSLSqv 1501
Cdd:cd22536   212 IRPGVSIPLQlqtipgaqaQVVTTLPINIGGVTLALPVINNVAAGGGSGQLVQPSDG--GVSNGNQLVSTPITTASVS-- 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1502 laqaagpTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLADTQgVLSGGLDTV 1581
Cdd:cd22536   288 -------TMPESPSSSTTCTTTASTSLTSSDTLVSSAETGQYASTAASSERTEEEPQTSAAESEAQSSSQ-LQSNGLQNV 359

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 569005364 1582 TLNitSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQS 1621
Cdd:cd22536   360 QDQ--SNSLQQVQIVGQPILQQIQIQQPQQQIIQAIQPQS 397
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
23-227 1.41e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364   23 DDDCPIPNFHKCEICLLSFPKESQFQRHMREHEQNDKPHRCDQCPQTFNVEFNLTLHKCTHNAEDP-----VCPV--CNK 95
Cdd:COG5048   252 DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGEslkpfSCPYslCGK 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364   96 KFSRVASLKAHIMLHEKEENLICSECGDEFTLHSqlAIHMEEHRQELANTRAHTckacKKEFETSPELKEhmkTHCKVRA 175
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP--LLNNEPPQSLQQYKDLKN----DKKSETLSNSCI---RNFKRDS 402

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569005364  176 SGTRSYNRNIDRSSFPYSCPHCGKTFQKPSQLTRHIRIHTGERPFKCSECGK 227
Cdd:COG5048   403 NLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1760-1785 1.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 1.45e-03
                           10        20
                   ....*....|....*....|....*.
gi 569005364  1760 ALQVHLKKHTGERPYRCDYCVMGFTQ 1785
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 194-239 1.84e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 1.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 569005364  194 CPHCGKTFQKPSQLTRHIRIHTgerpFKCSECGKAFNQKGALQTHM 239
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1655-1703 2.49e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 569005364 1655 CLDCDRAFSSAAVLMHHSKEVHGKerihgCRVCRKAFKRATHLKEHMLT 1703
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKHFK-----CHICHKKLYTAGGLAVHCLQ 47
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1189-1238 4.35e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 4.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569005364 1189 KPYkCDECGKSFTVKSTLDCHVKTHTgqklFSCHVCSNAFSTKGSLKVHM 1238
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
PHA00733 PHA00733
hypothetical protein
 530-580 5.34e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 5.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569005364  530 IKAFKCQYCMKSFSTSGSLKVHIRL--HTGVrpfaCPHCDKKFRTSGHRKTHV 580
Cdd:PHA00733   71 VSPYVCPLCLMPFSSSVSLKQHIRYteHSKV----CPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
646-1051 1.07e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  646 NEADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRG--FVSAGVLKAHVRTHTGLKSFKCLICNG-AFTTGGS 722
Cdd:COG5048    28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPlSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  723 LRRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQEaSSMDDDSTVDQQSMHVAAPMPVEIESAELQ 802
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNS-SSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  803 QTPETVAADPESILELGPQHvvgtedaalgqQLADQPLEADEDGFTASQAPLPGHMDQFEEQGTPQPSfesagLPQGFTV 882
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLS-----------SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-----SPSSLSS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  883 TDTYSQQTSFPPVQQLQDSSTLESQALSTSFHQQNLLQVPNSDAINvatrllPESSQEDlDLQTQGPQFLEDSEDQSRRS 962
Cdd:COG5048   251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCN------ISFSRSS-PLTRHLRSVNHSGESLKPFS 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  963 YRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKS-------HEKTHTGVKAFSC--SICNASFTTNGS 1033
Cdd:COG5048   324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSN 403

                         410
                  ....*....|....*...
gi 569005364 1034 LTRHMATHMSMKPYKCPF 1051
Cdd:COG5048   404 LSLHIITHLSFRPYNCKN 421
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 1333-1609 4.76e-08

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 58.62  E-value: 4.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1333 ASVSAGGDLTVSL--TDGSLATLEGIQLQLAANLVGPNVQIS--GIDASSINNITLQIDPSILQQTLQQGSLLAQPITGE 1408
Cdd:COG3210   802 GTITAAGTTAINVtgSGGTITINTATTGLTGTGDTTSGAGGSntTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGS 881

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1409 SSTASQNSSLQTSDSTVPASVVIQPLSGLSLQPTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVSTSTGphe 1488
Cdd:COG3210   882 GGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAAS--- 958

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1489 ITLTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLA 1568
Cdd:COG3210   959 ASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAA 1038

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 569005364 1569 DTQGVLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGS 1609
Cdd:COG3210  1039 TAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGG 1079
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-543 5.54e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 5.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  190 FPYSCPHCGKTFQKPSQLTRHIRIHTGERPFKCSECGKAFNQK--GALQTHMIKHTGEKPHACAfcpaafsqKGNLQSHV 267
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNS--------KSLPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  268 QRVHSEVKNGPTYNCTECSCVFKSLG------SLNTHISKMHMGGPPNSTTSaeTAHVITATIFQTLPLQQVEAQVSSVS 341
Cdd:COG5048   104 KASSSSLSSSSSNSNDNNLLSSHSLPpssrdpQLPDLLSISNLRNNPLPGNN--SSSVNTPQSNSLHPPLPANSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  342 SEQSSQAVSDVIQQLLELSEPGPVEAQQSPQSgrQLSVTVGINQDILQQALENSGLSslpvaaPPSDCSHAQTATVSTQS 421
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPS--SSSDQNLENSSSSLPLTTNSQLS------PKSLLSQSPSSLSSSDS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  422 PHASSVSAEQADPMDAEQEKgqespektdkkekkllkkkSPFLPGSIREENGVRWHVCPYCTKEFRKPSDLVRHIRIHTH 501
Cdd:COG5048   254 SSSASESPRSSLPTASSQSS-------------------SPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNH 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 569005364  502 E----KPFKCP--QCFRAFAVKSTLTAHIKTHTGIKAFKCQY--CMKSFS 543
Cdd:COG5048   315 SgeslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFS 364
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 1338-1626 4.98e-07

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 55.16  E-value: 4.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1338 GGDLTVslTDGSLATLEGIQLQLAANLVGPNVQISGIDASSINNITLQIDPSILQQTLqQGSLLAQPITGESSTASQNSS 1417
Cdd:COG3210   818 GGTITI--NTATTGLTGTGDTTSGAGGSNTTDTTTGTTSDGASGGGTAGANSGSLAAT-AASITVGSGGVATSTGTANAG 894

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1418 LQTSDSTVPASVVIQPLSGLSLQPTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVSTSTGPHEITLTINNSS 1497
Cdd:COG3210   895 TLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAASASDGAGDTGASSAAGS 974

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1498 LSQVLAQAAGPTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLADTQGVLSGG 1577
Cdd:COG3210   975 SAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAATAGGQNGVGVNASGIS 1054

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 569005364 1578 LDTVTLNITSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQSSSAAG 1626
Cdd:COG3210  1055 GGNAAALTASGTAGTTGGTAASNGGGGTAQASGAGTTHTLGGITNGGAT 1103
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1177-1201 2.67e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.44  E-value: 2.67e-06
                           10        20
                   ....*....|....*....|....*
gi 569005364  1177 DLVRHVRIHTGEKPYKCDECGKSFT 1201
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
930-1310 4.11e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  930 ATRLLPESSQEDLDLQTQGPQFLEDSEDQSRRSYRCDYCNKGFKKSSHLKQHVRSHTGEKPYKCKLCGRAFVSSGVLKSH 1009
Cdd:COG5048     1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1010 ---EKTHTGVKAFSCSICNASFTTNGSLTRHMATHMSMKPYKCPFCEEgfrtavhcrKHMKRHQAVSSAAAAAAETEGGD 1086
Cdd:COG5048    81 rhlRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSL---------PPSSRDPQLPDLLSISNLRNNPL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1087 TCVEEDEENSDRSASRKPRPEVITFTEEETAQLAKIqPQESATVSEKV------LVQSAAEKDRISEMKDKQAELEAEPK 1160
Cdd:COG5048   152 PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL-ISSNVSTSIPSssenspLSSSYSIPSSSSDQNLENSSSSLPLT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1161 HANCCTYCPKSFKKPSDLVRHVRIHTGEKPYKCDECGKSFTVKSTLDCHVKTHTGQKLFSCH-VCSNAFSTKGSLKVHMR 1239
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSkQCNISFSRSSPLTRHLR 310

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569005364 1240 --LHTG--AKPFKCPH--CELRFRTSGRRKTHMQFHYKSDPKKarKPVTRSSSESLQSVNLLNSSSTDPNVFIMNNS 1310
Cdd:COG5048   311 svNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK--EKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDK 385
zf-H2C2_2 pfam13465
Zinc-finger double domain;
977-1002 6.45e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 6.45e-06
                           10        20
                   ....*....|....*....|....*.
gi 569005364   977 HLKQHVRSHTGEKPYKCKLCGRAFVS 1002
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-231 6.77e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 6.77e-06
                           10        20
                   ....*....|....*....|....*
gi 569005364   207 LTRHIRIHTGERPFKCSECGKAFNQ 231
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1367-1668 1.11e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.69  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  1367 PNVQISGIDASSINNITLQIDPS----ILQQTLQQGSLLAQPITGESSTASQNSSLQTSDSTVPA---SVVIQPLSGLSL 1439
Cdd:pfam05109  567 PNATIPTLGKTSPTSAVTTPTPNatspTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTgqhNITSSSTSSMSL 646

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  1440 QPTVTSAnlTIGPLSEQDSV----LTTSS--SGSQDLSQVMTSqglvstSTGPHEITlTINNSSLSQVLAQAAGPTASSS 1513
Cdd:pfam05109  647 RPSSISE--TLSPSTSDNSTshmpLLTSAhpTGGENITQVTPA------STSTHHVS-TSSPAPRPGTTSQASGPGNSST 717

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  1514 SGSPQEITLTiselnpsSGSLP--STAPMSPSAISAQNLVMSSSGVGADASvtltladtqgvlSGGLDTvtlniTSQGQQ 1591
Cdd:pfam05109  718 STKPGEVNVT-------KGTPPknATSPQAPSGQKTAVPTVTSTGGKANST------------TGGKHT-----TGHGAR 773

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  1592 FPallTDPSLSGQGGAGSPQVILVSHT---PQSSSAAGEEIAYQVTDV-PAQLT----PHSQPEKEGLSHQCLDcdraFS 1663
Cdd:pfam05109  774 TS---TEPTTDYGGDSTTPRTRYNATTylpPSTSSKLRPRWTFTSPPVtTAQATvpvpPTSQPRFSNLSMLVLQ----WA 846


                   ....*
gi 569005364  1664 SAAVL 1668
Cdd:pfam05109  847 SLAVL 851
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1733-1757 1.15e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 1.15e-05
                           10        20
                   ....*....|....*....|....*
gi 569005364  1733 LERHSRIHTGERPFHCTLCDKAFNQ 1757
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
666-691 1.77e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 1.77e-05
                           10        20
                   ....*....|....*....|....*.
gi 569005364   666 HLKQHIRSHTGEKPFKCSQCGRGFVS 691
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 1281-1626 2.22e-05

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 49.76  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1281 VTRSSSESLQSVNLLNSSSTDPNVFIMNNSVLTGQFDQNVLQPGLVGQAILPASVSAGGDLTVSLTDGSLATLEGIQLQL 1360
Cdd:COG3210   509 GIATGLTGITAGGGGGGNATSGGTGGDGTTLSGSGLTTTVSGGASGTTAASGSNTANTLGVLAATGGTSNATTAGNSTSA 588

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1361 AANLVGPNVQISGIDASSINNITLQIDPSILQQTLQQGSLLAQPITGESSTASQNSSLQTSDSTVPASVVIQPLSGLSLQ 1440
Cdd:COG3210   589 TGGTGTNSGGTVLSIGTGSAGATGTITLGAGTSGAGANATGGGAGLTGSAVGAALSGTGSGTTGTASANGSNTTGVNTAG 668

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1441 PTVTSANLTIGPLSEQDSVLTTSSSGSQDL-----------SQVMTSQGLVSTSTGPHEITLTINNSSLSQVLAQAAGPT 1509
Cdd:COG3210   669 GTGGGTTGTVTSGATGGTTGTTLNAATGGTlnnagntltisTGSITVTGQIGALANANGDTVTFGNLGTGATLTLNAGVT 748

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1510 ASS-SSGSP------------QEITLTISELNPSSGSL--PSTAPMSPSAISAQNLVMSSSGV----GADASVTLTLADT 1570
Cdd:COG3210   749 ITSgNAGTLsigltanttasgTTLTLANANGNTSAGATldNAGAEISIDITADGTITAAGTTAinvtGSGGTITINTATT 828

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569005364 1571 qGVLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQSSSAAG 1626
Cdd:COG3210   829 -GLTGTGDTTSGAGGSNTTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGSGG 883
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 2.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 2.16e-04
                           10        20
                   ....*....|....*....|....*.
gi 569005364   547 SLKVHIRLHTGVRPFACPHCDKKFRT 572
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 650-701 2.26e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 2.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569005364  650 RPYkCFYCHRAYKKSCHLKQHIRSHTgekpFKCSQCGRGFVSAGVLKAHVRT 701
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 192-214 2.39e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 2.39e-04
                           10        20
                   ....*....|....*....|...
gi 569005364   192 YSCPHCGKTFQKPSQLTRHIRIH 214
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1033-1058 3.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 3.88e-04
                           10        20
                   ....*....|....*....|....*.
gi 569005364  1033 SLTRHMATHMSMKPYKCPFCEEGFRT 1058
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 678-727 4.57e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.62  E-value: 4.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569005364  678 KPFkCSQCGRGFVSAGVLKAHVRTHTglksFKCLICNGAFTTGGSLRRHM 727
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1233-1258 5.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 5.98e-04
                           10        20
                   ....*....|....*....|....*.
gi 569005364  1233 SLKVHMRLHTGAKPFKCPHCELRFRT 1258
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 965-1009 6.38e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 6.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 569005364  965 CDYCNKGFKKSSHLKQHVRSHTgekpYKCKLCGRAFVSSGVLKSH 1009
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 1355-1621 9.57e-04

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 44.14  E-value: 9.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1355 GIQLQLAANLV---GPNVQISGIDASSINNITLQIdpsilqQTLQQGSLLAqPITGESSTASQNSSLQ-TSDSTVPasVV 1430
Cdd:cd22536   141 SVQYQVIPQIQtveGQQIQISPANATALQDLQGQI------QLIPAGNNQA-ILTTPNRTASGNIIAQnLANQTVP--VQ 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1431 IQPLSGLSLQ---------PTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGlvSTSTGPHEITLTINNSSLSqv 1501
Cdd:cd22536   212 IRPGVSIPLQlqtipgaqaQVVTTLPINIGGVTLALPVINNVAAGGGSGQLVQPSDG--GVSNGNQLVSTPITTASVS-- 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1502 laqaagpTASSSSGSPQEITLTISELNPSSGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLADTQgVLSGGLDTV 1581
Cdd:cd22536   288 -------TMPESPSSSTTCTTTASTSLTSSDTLVSSAETGQYASTAASSERTEEEPQTSAAESEAQSSSQ-LQSNGLQNV 359

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 569005364 1582 TLNitSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQS 1621
Cdd:cd22536   360 QDQ--SNSLQQVQIVGQPILQQIQIQQPQQQIIQAIQPQS 397
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 963-985 1.34e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 1.34e-03
                           10        20
                   ....*....|....*....|...
gi 569005364   963 YRCDYCNKGFKKSSHLKQHVRSH 985
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
23-227 1.41e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364   23 DDDCPIPNFHKCEICLLSFPKESQFQRHMREHEQNDKPHRCDQCPQTFNVEFNLTLHKCTHNAEDP-----VCPV--CNK 95
Cdd:COG5048   252 DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGEslkpfSCPYslCGK 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364   96 KFSRVASLKAHIMLHEKEENLICSECGDEFTLHSqlAIHMEEHRQELANTRAHTckacKKEFETSPELKEhmkTHCKVRA 175
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP--LLNNEPPQSLQQYKDLKN----DKKSETLSNSCI---RNFKRDS 402

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569005364  176 SGTRSYNRNIDRSSFPYSCPHCGKTFQKPSQLTRHIRIHTGERPFKCSECGK 227
Cdd:COG5048   403 NLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1760-1785 1.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 1.45e-03
                           10        20
                   ....*....|....*....|....*.
gi 569005364  1760 ALQVHLKKHTGERPYRCDYCVMGFTQ 1785
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 194-239 1.84e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 1.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 569005364  194 CPHCGKTFQKPSQLTRHIRIHTgerpFKCSECGKAFNQKGALQTHM 239
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1655-1703 2.49e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 569005364 1655 CLDCDRAFSSAAVLMHHSKEVHGKerihgCRVCRKAFKRATHLKEHMLT 1703
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKHFK-----CHICHKKLYTAGGLAVHCLQ 47
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 220-242 2.49e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 2.49e-03
                           10        20
                   ....*....|....*....|...
gi 569005364   220 FKCSECGKAFNQKGALQTHMIKH 242
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 477-499 3.12e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 3.12e-03
                           10        20
                   ....*....|....*....|...
gi 569005364   477 HVCPYCTKEFRKPSDLVRHIRIH 499
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 503-551 3.31e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 3.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 569005364  503 KPFkCPQCFRAFAVKSTLTAHIKTHTgikaFKCQYCMKSFSTSGSLKVH 551
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1189-1238 4.35e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 4.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 569005364 1189 KPYkCDECGKSFTVKSTLDCHVKTHTgqklFSCHVCSNAFSTKGSLKVHM 1238
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
722-747 4.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 4.48e-03
                           10        20
                   ....*....|....*....|....*.
gi 569005364   722 SLRRHMGIHNDLRPYMCPYCQKTFKT 747
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 530-580 5.34e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 5.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 569005364  530 IKAFKCQYCMKSFSTSGSLKVHIRL--HTGVrpfaCPHCDKKFRTSGHRKTHV 580
Cdd:PHA00733   71 VSPYVCPLCLMPFSSSVSLKQHIRYteHSKV----CPVCGKEFRNTDSTLDHV 119
SP3_N cd22537
N-terminal domain of transcription factor Specificity Protein (SP) 3; Specificity Proteins ...
 1331-1646 5.57e-03

N-terminal domain of transcription factor Specificity Protein (SP) 3; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP1 and SP3 can interact with and recruit a large number of proteins including the transcription initiation complex, histone modifying enzymes, and chromatin remodeling complexes, which strongly suggest that SP1 and SP3 are important transcription factors in remodeling chromatin and the regulation of gene expression. SP3 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP3.


Pssm-ID: 411774 [Multi-domain]  Cd Length: 574  Bit Score: 41.47  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1331 LPASVSAGGDLTVSLTDGSLATLEGIQLQLAAN---LVGPNVQISGIDASSInnitLQIDPSILQQTLQQGSLLAQPITG 1407
Cdd:cd22537    24 SPSPGDDAAAAGNAASAGQTGDLASAQLTGAPNrweVLTPTPTTIKDEAGNL----VQIPGGGTVTSSGQYVLPLQSLQN 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1408 ES--STASQNSSLQTSDSTVPASVV--IQPLSGLSLQ--PTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVS 1481
Cdd:cd22537   100 QQifSVAPGSDASNGTVPNVQYQVIpqIQTTDGQQVQlgFATSSDNTGLQQEGGQIQIIPGSNQTIIASGTPSAVQQLLS 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1482 TSTGPHEI-TLTINNSSL---SQVLAQAAgptasssSGSPQEITLT-ISELNPSS-GSLPSTAPMSPSAISAQNLVM--- 1552
Cdd:cd22537   180 QSGHVVQIqGVSIGGSSFpgqTQVVANVP-------LGLPGNITFVpINSVDLDSlGLSGTSQTMTTGITADGQLINtgq 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364 1553 ---SSSGVGADASVTLTLADTQG-------VLSGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGSPQVILVSHTPQSS 1622
Cdd:cd22537   253 avqSSDNSGESGKVSPDINETNTnadlfvpTSSSSQLPVTIDSTGILQQNASSLTTVSGQVHTSDLQGNYIQAPVSDETQ 332

                         330       340
                  ....*....|....*....|....
gi 569005364 1623 SAAGEEIAYQVTDVPAQLTPHSQP 1646
Cdd:cd22537   333 AQNIQVSTAQPSVQQIQLHESQQP 356
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
43-313 5.71e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364   43 KESQFQRHMREHEQNDKPHRCDQCPQTFNVEFNLTLHKCTHNAEDP-VCPV--CNKKFSRVASLKAHIMLH--------- 110
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPsQCSYsgCDKSFSRPLELSRHLRTHhnnpsdlns 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  111 ----------EKEENLICSECGDEFTLHSQLAIHMEEHRQELANTRAHT-------------CKACKKEFETSPELKEHM 167
Cdd:COG5048    96 kslplsnskaSSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrnnplpgnnssSVNTPQSNSLHPPLPANS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569005364  168 KTHCKVRASGTRSYNRNIDRSSFPYSCPHCGKTFQKPSQLTRHIRIH-TGERPFKCSECGKAFNQKGALQTHmIKHTGEK 246
Cdd:COG5048   176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSS-LSSSDSS 254

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569005364  247 PHACAFCPAAFSQKGNLQSHVQRVHSEVKNGPT--YNCTECSCVFKSLGSLNTHISKMHMGGPPNSTTS 313
Cdd:COG5048   255 SSASESPRSSLPTASSQSSSPNESDSSSEKGFSlpIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFS 323
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1710-1779 7.64e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 7.64e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569005364 1710 LSSQKPRVFKCDSCEKAFAKPSQLERHSRIHTGERPFHCTL--CDKAFNQKSALQVHLKKHTGERPYRCDYC 1779
Cdd:COG5048    26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97
zf-H2C2_2 pfam13465
Zinc-finger double domain;
520-544 7.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 7.91e-03
                           10        20
                   ....*....|....*....|....*
gi 569005364   520 LTAHIKTHTGIKAFKCQYCMKSFST 544
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1019-1041 9.29e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 9.29e-03
                           10        20
                   ....*....|....*....|...
gi 569005364  1019 FSCSICNASFTTNGSLTRHMATH 1041
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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