serine protease inhibitor Kazal-type 8 isoform X1 [Mus musculus]
Protein Classification
Kazal-type serine protease inhibitor family protein( domain architecture ID 252)
Kazal-type serine protease inhibitor family protein may function as a serine protease inhibitor
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| KAZAL_FS super family | cl00097 | Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ... |
49-96 | 1.05e-11 | ||
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD. The actual alignment was detected with superfamily member cd01327: Pssm-ID: 412159 Cd Length: 45 Bit Score: 54.60 E-value: 1.05e-11
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| Name | Accession | Description | Interval | E-value | ||
| KAZAL_PSTI | cd01327 | Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ... |
49-96 | 1.05e-11 | ||
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the superfamily of kazal-type proteinase inhibitors and follistatin-like proteins. Pssm-ID: 238648 Cd Length: 45 Bit Score: 54.60 E-value: 1.05e-11
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| Kazal_1 | pfam00050 | Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ... |
61-96 | 9.29e-09 | ||
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family. Pssm-ID: 395004 Cd Length: 49 Bit Score: 47.28 E-value: 9.29e-09
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| KAZAL | smart00280 | Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ... |
58-96 | 4.20e-07 | ||
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains. Pssm-ID: 197624 Cd Length: 46 Bit Score: 43.05 E-value: 4.20e-07
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| Name | Accession | Description | Interval | E-value | ||
| KAZAL_PSTI | cd01327 | Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ... |
49-96 | 1.05e-11 | ||
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the superfamily of kazal-type proteinase inhibitors and follistatin-like proteins. Pssm-ID: 238648 Cd Length: 45 Bit Score: 54.60 E-value: 1.05e-11
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| Kazal_1 | pfam00050 | Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ... |
61-96 | 9.29e-09 | ||
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family. Pssm-ID: 395004 Cd Length: 49 Bit Score: 47.28 E-value: 9.29e-09
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| KAZAL | smart00280 | Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ... |
58-96 | 4.20e-07 | ||
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains. Pssm-ID: 197624 Cd Length: 46 Bit Score: 43.05 E-value: 4.20e-07
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| KAZAL_FS | cd00104 | Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ... |
58-96 | 5.06e-07 | ||
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD. Pssm-ID: 238052 [Multi-domain] Cd Length: 41 Bit Score: 42.64 E-value: 5.06e-07
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| Kazal_2 | pfam07648 | Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ... |
61-96 | 3.48e-03 | ||
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Pssm-ID: 400135 Cd Length: 50 Bit Score: 32.85 E-value: 3.48e-03
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