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Conserved domains on  [gi|568960038|ref|XP_006510654|]
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beta-galactosidase-1-like protein 3 isoform X1 [Mus musculus]

Protein Classification

glycoside hydrolase family 35 protein( domain architecture ID 10472897)

glycoside hydrolase family 35 protein similar to Xanthomonas phaseoli beta-galactosidase that catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

CAZY:  GH35
EC:  3.2.1.-
Gene Ontology:  GO:0004565|GO:0005975
SCOP:  4003303

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
69-379 2.25e-140

Glycosyl hydrolases family 35;


:

Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 412.42  E-value: 2.25e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038   69 FTLEGHKFMIVGGSIHYFRVPREYWKDRLLKLQACGFNTVTTYIPWNLHEQERGKFDFSEILDLEAYVLLAKTIGLWVIL 148
Cdd:pfam01301   2 FLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038  149 RPGPYICAEVDLGGLPSWLLRNPVTDLRTTNKGFIEAVDKYFDHLIPKILPLQYRHGGPVIAVQVENEYGSFQKDRNYMN 228
Cdd:pfam01301  82 RPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYLR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038  229 YLKKALLKRGIVELLLTSDD---KDGIQIGSVNGA--LTTINM--NSFTKDSFIKLHKMQSDKPIMIMEYWTGWYDSWGS 301
Cdd:pfam01301 162 ALRKAYKEWGADMALLFTTDgpwGMCLQCGDLPGPdiYATNGFgcGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHWGG 241
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960038  302 KHIEKSAEEIRHTVYKFISYGLSFNMYMFHGGTNFGFINGGryeNHHISVVTSYDYDAVLSEAGDYTEKYFKLRKLFA 379
Cdd:pfam01301 242 PHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGA---NFYGPQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
69-379 2.25e-140

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 412.42  E-value: 2.25e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038   69 FTLEGHKFMIVGGSIHYFRVPREYWKDRLLKLQACGFNTVTTYIPWNLHEQERGKFDFSEILDLEAYVLLAKTIGLWVIL 148
Cdd:pfam01301   2 FLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038  149 RPGPYICAEVDLGGLPSWLLRNPVTDLRTTNKGFIEAVDKYFDHLIPKILPLQYRHGGPVIAVQVENEYGSFQKDRNYMN 228
Cdd:pfam01301  82 RPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYLR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038  229 YLKKALLKRGIVELLLTSDD---KDGIQIGSVNGA--LTTINM--NSFTKDSFIKLHKMQSDKPIMIMEYWTGWYDSWGS 301
Cdd:pfam01301 162 ALRKAYKEWGADMALLFTTDgpwGMCLQCGDLPGPdiYATNGFgcGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHWGG 241
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960038  302 KHIEKSAEEIRHTVYKFISYGLSFNMYMFHGGTNFGFINGGryeNHHISVVTSYDYDAVLSEAGDYTEKYFKLRKLFA 379
Cdd:pfam01301 242 PHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGA---NFYGPQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
PLN03059 PLN03059
beta-galactosidase; Provisional
69-377 2.62e-52

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 193.68  E-value: 2.62e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038  69 FTLEGHKFMIVGGSIHYFRVPREYWKDRLLKLQACGFNTVTTYIPWNLHEQERGKFDFSEILDLEAYVLLAKTIGLWVIL 148
Cdd:PLN03059  37 FIINGQRRILISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVKFIKVVQAAGLYVHL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 149 RPGPYICAEVDLGGLPSWLLRNPVTDLRTTNKGFIEAVDKYFDHLIP--KILPLQYRHGGPVIAVQVENEYGSFQKD--- 223
Cdd:PLN03059 117 RIGPYICAEWNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEKIVDmmKSEKLFEPQGGPIILSQIENEYGPVEWEiga 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 224 --RNYMNYLKKALLK--RGIVELLLTSDDKDGIQIGSVNGalttinmnsFTKDSFiklhKMQSD-KPIMIMEYWTGWYDS 298
Cdd:PLN03059 197 pgKAYTKWAADMAVKlgTGVPWVMCKQEDAPDPVIDTCNG---------FYCENF----KPNKDyKPKMWTEAWTGWYTE 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 299 WGSKHIEKSAEEIRHTVYKFISYGLSF-NMYMFHGGTNFGFINGGRYenhhisVVTSYDYDAVLSEAGDYTE-KYFKLRK 376
Cdd:PLN03059 264 FGGAVPNRPAEDLAFSVARFIQNGGSFiNYYMYHGGTNFGRTAGGPF------IATSYDYDAPLDEYGLPREpKWGHLRD 337

                 .
gi 568960038 377 L 377
Cdd:PLN03059 338 L 338
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
76-379 9.43e-47

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 174.73  E-value: 9.43e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038  76 FMIVGGSIHYFRVPREYWKDRLLKLQACGFNTVTT-YIPWNLHEQERGKFDFSeilDLEAYVLLAKTIGLWVILRPGPYI 154
Cdd:COG1874    9 FLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRIgYFAWNLHEPEEGVFDFD---WLDRFIDLLHEAGLKVILRTPTAA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 155 caevdlggLPSWLLRN-----PVTDLRT------------TNKGFIEAVDKYFDHLIPkilplQYRHGGPVIAVQVENEY 217
Cdd:COG1874   86 --------PPAWLLKKypeilPVDADGRrrgfgsrrhycpSSPVYREAARRIVRALAE-----RYGDHPAVIMWQVDNEY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 218 GSFQKDRN----YMNYLKKallKRGIVELL----------LTSDDKDgiQIGSVNGALTTINM------NSFTKDSFIKL 277
Cdd:COG1874  153 GSYDYCDAcaaaFRDWLRE---RYGTLDALneawgtafwsQRYTDWD--EIEPPRLTPTTANPslrldfRRFSSDQVLEY 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 278 HKMQSD---------------------------------------------------------------KPIMIMEYWTG 294
Cdd:COG1874  228 LRAQRDilreagpdvpvttnfmgpfpgldywklardldvvswdnypdgsaadpdeiafahdlmrglkggGPFMVMEQWPG 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 295 WYdSWGSKHIEKSAEEIRHTVYKFISYGLS-FNMYMFHgGTNFGfinggryenhhisvvTSYDYDAVLSEAGDYTEKYFK 373
Cdd:COG1874  308 WV-NWGPYNPAKRPGQLRLWSLQALAHGADgVNYFQWR-PSRGG---------------TEYDHDAPLDHAGRPTRKFRE 370

                 ....*.
gi 568960038 374 LRKLFA 379
Cdd:COG1874  371 VRELGA 376
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
69-379 2.25e-140

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 412.42  E-value: 2.25e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038   69 FTLEGHKFMIVGGSIHYFRVPREYWKDRLLKLQACGFNTVTTYIPWNLHEQERGKFDFSEILDLEAYVLLAKTIGLWVIL 148
Cdd:pfam01301   2 FLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038  149 RPGPYICAEVDLGGLPSWLLRNPVTDLRTTNKGFIEAVDKYFDHLIPKILPLQYRHGGPVIAVQVENEYGSFQKDRNYMN 228
Cdd:pfam01301  82 RPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYLR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038  229 YLKKALLKRGIVELLLTSDD---KDGIQIGSVNGA--LTTINM--NSFTKDSFIKLHKMQSDKPIMIMEYWTGWYDSWGS 301
Cdd:pfam01301 162 ALRKAYKEWGADMALLFTTDgpwGMCLQCGDLPGPdiYATNGFgcGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHWGG 241
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568960038  302 KHIEKSAEEIRHTVYKFISYGLSFNMYMFHGGTNFGFINGGryeNHHISVVTSYDYDAVLSEAGDYTEKYFKLRKLFA 379
Cdd:pfam01301 242 PHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGA---NFYGPQTTSYDYDAPIDEAGDPTPKYGHLKDLIT 316
PLN03059 PLN03059
beta-galactosidase; Provisional
69-377 2.62e-52

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 193.68  E-value: 2.62e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038  69 FTLEGHKFMIVGGSIHYFRVPREYWKDRLLKLQACGFNTVTTYIPWNLHEQERGKFDFSEILDLEAYVLLAKTIGLWVIL 148
Cdd:PLN03059  37 FIINGQRRILISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVKFIKVVQAAGLYVHL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 149 RPGPYICAEVDLGGLPSWLLRNPVTDLRTTNKGFIEAVDKYFDHLIP--KILPLQYRHGGPVIAVQVENEYGSFQKD--- 223
Cdd:PLN03059 117 RIGPYICAEWNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEKIVDmmKSEKLFEPQGGPIILSQIENEYGPVEWEiga 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 224 --RNYMNYLKKALLK--RGIVELLLTSDDKDGIQIGSVNGalttinmnsFTKDSFiklhKMQSD-KPIMIMEYWTGWYDS 298
Cdd:PLN03059 197 pgKAYTKWAADMAVKlgTGVPWVMCKQEDAPDPVIDTCNG---------FYCENF----KPNKDyKPKMWTEAWTGWYTE 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 299 WGSKHIEKSAEEIRHTVYKFISYGLSF-NMYMFHGGTNFGFINGGRYenhhisVVTSYDYDAVLSEAGDYTE-KYFKLRK 376
Cdd:PLN03059 264 FGGAVPNRPAEDLAFSVARFIQNGGSFiNYYMYHGGTNFGRTAGGPF------IATSYDYDAPLDEYGLPREpKWGHLRD 337

                 .
gi 568960038 377 L 377
Cdd:PLN03059 338 L 338
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
76-379 9.43e-47

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 174.73  E-value: 9.43e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038  76 FMIVGGSIHYFRVPREYWKDRLLKLQACGFNTVTT-YIPWNLHEQERGKFDFSeilDLEAYVLLAKTIGLWVILRPGPYI 154
Cdd:COG1874    9 FLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRIgYFAWNLHEPEEGVFDFD---WLDRFIDLLHEAGLKVILRTPTAA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 155 caevdlggLPSWLLRN-----PVTDLRT------------TNKGFIEAVDKYFDHLIPkilplQYRHGGPVIAVQVENEY 217
Cdd:COG1874   86 --------PPAWLLKKypeilPVDADGRrrgfgsrrhycpSSPVYREAARRIVRALAE-----RYGDHPAVIMWQVDNEY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 218 GSFQKDRN----YMNYLKKallKRGIVELL----------LTSDDKDgiQIGSVNGALTTINM------NSFTKDSFIKL 277
Cdd:COG1874  153 GSYDYCDAcaaaFRDWLRE---RYGTLDALneawgtafwsQRYTDWD--EIEPPRLTPTTANPslrldfRRFSSDQVLEY 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 278 HKMQSD---------------------------------------------------------------KPIMIMEYWTG 294
Cdd:COG1874  228 LRAQRDilreagpdvpvttnfmgpfpgldywklardldvvswdnypdgsaadpdeiafahdlmrglkggGPFMVMEQWPG 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038 295 WYdSWGSKHIEKSAEEIRHTVYKFISYGLS-FNMYMFHgGTNFGfinggryenhhisvvTSYDYDAVLSEAGDYTEKYFK 373
Cdd:COG1874  308 WV-NWGPYNPAKRPGQLRLWSLQALAHGADgVNYFQWR-PSRGG---------------TEYDHDAPLDHAGRPTRKFRE 370

                 ....*.
gi 568960038 374 LRKLFA 379
Cdd:COG1874  371 VRELGA 376
Glyco_hydro_42 pfam02449
Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase ...
86-218 8.84e-09

Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.


Pssm-ID: 396834  Cd Length: 376  Bit Score: 58.05  E-value: 8.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960038   86 FRVPREYWKDRLLKLQACGFNTVT-TYIPWNLHEQERGKFDFS---EILDleayvLLAKTiGLWVILRPGPyicaevdlG 161
Cdd:pfam02449   5 EQWPEETWEEDIRLMKEAGVNVVRiGIFAWAKLEPEEGKYDFEwldEVID-----LLAKA-GIKVILATPT--------A 70
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568960038  162 GLPSWLLR-----NPVT------------DLRTTNKGFIEAVDKyfdhlIPKILPLQYRHGGPVIAVQVENEYG 218
Cdd:pfam02449  71 APPAWLVKkhpeiLPVDadgrrrgfgsrhHYCPSSPVYREYAAR-----IVEALAERYGDHPALIGWHIDNEYG 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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